| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Trenkwalder, Teresa, et al.
(författare)
-
Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis
- 2019
-
Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 276, s. 212-217
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21 loci, i.e. the two strongest CAD risk loci, with risk of AVS. Methods: We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS. Cases and controls were stratified by CAD status. External validation of findings was undertaken in five cohorts including 7880 cases and 851,152 controls. Results: In the meta-analysis including 4651 cases and 8231 controls the CAD-associated allele at the LPA locus was associated with increased risk of AVS (OR 1.37; 95%CI 1.24–1.52, p = 6.9 × 10−10) with a larger effect size in those without CAD (OR 1.53; 95%CI 1.31–1.79) compared to those with CAD (OR 1.27; 95%CI 1.12–1.45). The CAD-associated allele at 9p21 was associated with a trend towards lower risk of AVS (OR 0.93; 95%CI 0.88–0.99, p = 0.014). External validation confirmed the association of the LPA risk allele with risk of AVS (OR 1.37; 95%CI 1.27–1.47), again with a higher effect size in those without CAD. The small protective effect of the 9p21 CAD risk allele could not be replicated (OR 0.98; 95%CI 0.95–1.02). Conclusions: Our study confirms the association of the LPA locus with risk of AVS, with a higher effect in those without concomitant CAD. Overall, 9p21 was not associated with AVS.
|
|
| 6. |
- Callegati, F., et al.
(författare)
-
Research on Optical Core Networks in the e-Photon/ONe Network of Excellence
- 2006
-
Ingår i: 25TH IEEE INTERNATIONAL CONFERENCE ON COMPUTER COMMUNICATIONS, VOLS 1-7, PROCEEDINGS IEEE INFOCOM 2006. ; , s. 2987-2991
-
Konferensbidrag (refereegranskat)abstract
- This papers reports the advances in optical core networks research coordinated in the framework of the e- photon/ONe and e-photon/ONe+ networks of excellence.
|
|
| 7. |
- Carraminana, Albert, et al.
(författare)
-
Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
-
Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
|
|
| 8. |
- Reverté, Sara, et al.
(författare)
-
National records of 3000 European bee and hoverfly species : A contribution to pollinator conservation
- 2023
-
Ingår i: Insect Conservation and Diversity. - 1752-458X. ; 16:6, s. 758-775
-
Tidskriftsartikel (refereegranskat)abstract
- Pollinators play a crucial role in ecosystems globally, ensuring the seed production of most flowering plants. They are threatened by global changes and knowledge of their distribution at the national and continental levels is needed to implement efficient conservation actions, but this knowledge is still fragmented and/or difficult to access. As a step forward, we provide an updated list of around 3000 European bee and hoverfly species, reflecting their current distributional status at the national level (in the form of present, absent, regionally extinct, possibly extinct or non-native). This work was attainable by incorporating both published and unpublished data, as well as knowledge from a large set of taxonomists and ecologists in both groups. After providing the first National species lists for bees and hoverflies for many countries, we examine the current distributional patterns of these species and designate the countries with highest levels of species richness. We also show that many species are recorded in a single European country, highlighting the importance of articulating European and national conservation strategies. Finally, we discuss how the data provided here can be combined with future trait and Red List data to implement research that will further advance pollinator conservation.
|
|
| 9. |
- Freidovich, Leonid, et al.
(författare)
-
Modification via averaging of partial-energy-shaping control for creating oscillations : cart-pendulum example
- 2009
-
Ingår i: International Journal of Control. - : Informa UK Limited. - 0020-7179 .- 1366-5820. ; 82:9, s. 1582-1590
-
Tidskriftsartikel (refereegranskat)abstract
- We consider the challenging problem of creating oscillations in underactuated mechanical systems. Target oscillatory motions of the indirectly actuated degree of freedom of a mechanical system can often be achieved via a straightforward to design feedback transformation. Moreover, the corresponding part of the dynamics can be forced to match a desired second-order system possessing the target periodic solution (Aracil, J., Gordillo, F., and Acosta, J.A. (2002), 'Stabilization of Oscillations in the Inverted Pendulum', in Proceedings of the 15th IFAC World Congress, Barcelona, Spain; Canudas-de-Wit, C., Espiau, B., and Urrea, C. (2002), 'Orbital Stabilisation of Underactuated Mechanical Systems', in Proceedings of the 15th IFAC World Congress, Barcelona, Spain). Sometimes, it is possible to establish the presence of periodic or bounded motions for the remaining degrees of freedom in the transformed system. However, typically this motion planning procedure leads to an open-loop unstable orbit and by necessity should be followed by a feedback control design. We propose a new approach for synthesis of a (practically) stabilising feedback controller, which ensures convergence of the solutions of the closed-loop system into a narrow tube around the preplanned orbit. The method is illustrated in detail by shaping oscillations in the inverted pendulum on a cart around its upright equilibrium. The complete analysis is based on application of a non-standard higher-order averaging technique assuming sufficiently high frequency of oscillations and is presented for this particular example.
|
|
| 10. |
- Freidovich, Leonid, 1973-, et al.
(författare)
-
Partial-energy-shaping control for orbital stabilization of high frequency oscillations of the Furuta pendulum
- 2007
-
Ingår i: PROCEEDINGS OF THE 46TH IEEE CONFERENCE ON DECISION AND CONTROL, VOLS 1-14. - 9781424414970 ; , s. 1432-1437
-
Konferensbidrag (refereegranskat)abstract
- We consider the problem of creating oscillations of the Furuta pendulum around the open-loop unstable equilibrium. Following a recently proposed technique, we start with shaping the energy of the unactuated link. An dissipativity-based controller is designed to create oscillations, neglecting possibility of unbounded motion of the directly actuated link. After that, an auxiliary linear feedback action is added to the control law, stabilizing a desired level of the reshaped energy. Parameters of the controller are tuned to approximately keep the originally created oscillations but ensuring bounded motion of both links. The analysis is valid only for oscillations of sufficiently high frequency and is based on higher order averaging technique. Performance of the designed controller is verified using numerical simulations and experiments.
|
|
| 11. |
- Freidovich, Leonid, et al.
(författare)
-
Partial-energy-shaping control for orbital stabilization of high-frequency oscillations of the furuta pendulum
- 2009
-
Ingår i: IEEE Transactions on Control Systems Technology. - 1063-6536 .- 1558-0865. ; 17:4, s. 853-858
-
Tidskriftsartikel (refereegranskat)abstract
- We consider the problem of creating oscillations of the Furuta pendulum around the open-loop unstable equilibrium. We start with a control transformation shaping the energy of the passive link. Then, a dissipativity-based controller is designed to create oscillations, neglecting the possibility of unbounded motion of the directly actuated link. After that, an auxiliary linear feedback action is added to the control law stabilizing a desired level of the reshaped energy. Parameters of the controller are tuned to approximately keep the originally created oscillations but ensuring bounded motion of both links. The analysis is valid only for oscillations of sufficiently high frequency and is based on higher order averaging technique. The performance of the designed controller is verified using numerical simulations as well as experimentally.
|
|
