| 1. |
- Abelev, Betty, et al.
(författare)
-
Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
-
Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
-
Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
|
|
| 2. |
- Abelev, Betty, et al.
(författare)
-
Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
-
Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
-
Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
|
|
| 3. |
- Abelev, Betty, et al.
(författare)
-
Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
-
Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
-
Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
|
|
| 4. |
- Aronsson, Andreas, et al.
(författare)
-
Översiktlig kustinventering 2002-2004 - Inventering och bedömning av stränder i Västernorrland
- 2005
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Huvudsyftet med denna översiktliga kustinventering har varit att peka ut områden som är viktiga för att bevara den biologiska mångfalden längs länets kust. Inventeringen omfattar landområdet inom 300 m från strandlinjen och ner till ca 1 meters djup ut i vattnet. Förutom en klassificering av den fysiska påverkansgraden längs stränderna för hela länets kuststräcka har även 356 objekt med indikationer på höga naturvärden inventerats i fält. Dessa områden har plockats ut med hjälp av kartor och flygbilder utifrån vissa utvalda biotoper som t. ex. sandstränder, grunda vikar, avsnörda vikar, vattendragsmynningar och vattensamlingar.Fältinventeringen har främst omfattat kärlväxter, makroalger, bottenfauna, strandskalbaggar samt mindre- och större vattensalamander. Inventeringen har genomförts under åren 2002 - 2004. Ångermanlandskusten inventerades 2002- 2003 och medelpadskusten 2004.
|
|
| 5. |
- Hummel, Sandra, et al.
(författare)
-
Associations of breastfeeding with childhood autoimmunity, allergies, and overweight : The Environmental Determinants of Diabetes in the Young (TEDDY) study
- 2021
-
Ingår i: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 114:1, s. 134-142
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Breastfeeding has beneficial effects on numerous health outcomes.OBJECTIVES: We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.METHODS: Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of developing autoimmunity or allergy were assessed using Cox proportional hazards models, and the risk of obesity at 5.5 y of age was assessed using logistic regression with adjustment by the propensity score.RESULTS: Breastfeeding duration was not associated with a lower risk of either islet or transglutaminase autoimmunity (any breastfeeding >6 mo, adjusted HR: 1.07; 95% CI: 0.96, 1.19; exclusive breastfeeding >3 mo, adjusted HR: 1.03; 95% CI: 0.92, 1.15). Exclusive breastfeeding >3 mo was associated with a decreased risk of seasonal allergic rhinitis (adjusted HR: 0.70; 95% CI: 0.53, 0.92; P < 0.01). Any breastfeeding >6 mo and exclusive breastfeeding >3 mo were associated with decreased risk of obesity (adjusted OR: 0.62; 95% CI: 0.47, 0.81; P < 0.001; and adjusted OR: 0.68; 95% CI: 0.47, 0.95; P < 0.05, respectively).CONCLUSIONS: Longer breastfeeding was not associated with a lower risk of childhood (islet or transglutaminase) autoimmunity in genetically at-risk children but was associated with decreased risk of seasonal allergic rhinitis and obesity at 5.5 y of age.
|
|
| 6. |
|
|
| 7. |
- Andersson, Dan, 1966-, et al.
(författare)
-
Risk Management in Outsourced Logistics
- 2004
-
Ingår i: Annual NOFOMA Conference for Nordic Researchers in Logistics: Challenging Boundaries with Logistics.,2004. - Linköping : Linköpings universitet. ; , s. 35-, s. 35-51
-
Konferensbidrag (refereegranskat)
|
|
| 8. |
- Aronsson, Andreas, et al.
(författare)
-
Biological effects of Wood Ash Application.
- 2004
-
Ingår i: Journal of Environmental Quality. - 0047-2425 .- 1537-2537. ; 33:5, s. 1595-1605
-
Tidskriftsartikel (refereegranskat)abstract
- The Swedish National Board of Forestry recommends recycling of wood ash for two main reasons: 1) to avoid depletion of essential soil nutrients, and 2) to reduce the harmful effects of acidification of surface waters. There is no doubt that recycling of wood ash to boreal forests will become a major industry in the near future. Much research is conducted regarding the effects of wood ash application on forest growth. Present studies show that, generally speaking, forest growth can be increased on wood ash-ameliorated peatland rich in nitrogen. On mineral soils, however, no change or even decreased growth has been reported. The effects on ground vegetation are not very clear, as well as the effects on fungi, soil microbes and soil decomposing animals. The discrepancies between different studies are for the most part explained by abiotic factors such as variation in fertility among sites, different degrees of stabilization and wood ash dosage used, and different time scales among different studies. The lack of knowledge in the field of aquatic ecosystems and their response to ash application is an important issue for future research. The few studies conducted have mainly considered changes in water chemistry. The biotoxic effects of ash application can roughly be divided into two categories: primary and secondary. Among the primary effects is toxicity deriving from compounds in the wood ash and cadmium is probably the worst among these. The secondary effects of wood ash are generally due to its alkaline capacity and a release of ions into the soil and soil water, and finally, watercourses and lakes. The present review aims to summarize current knowledge in the topic of wood ash application to boreal forest and aquatic ecosystems, and the different effects derived from these actions. ABBREVIATIONS: WAA, Wood ash application; MT, metric tonnes
|
|
| 9. |
- Aronsson, Andreas, et al.
(författare)
-
Biological effects of wood ash application to forest and aquatic ecosystems
- 2004
-
Ingår i: Journal of Environmental Quality. - : Wiley. - 0047-2425 .- 1537-2537. ; 33:5, s. 1595-1605
-
Forskningsöversikt (refereegranskat)abstract
- The present review aims to summarize current knowledge in the topic of wood ash application to boreal forest and aquatic ecosystems, and the different effects derived from these actions. Much research has been conducted regarding the effects of wood ash application on forest growth. Present studies show that, generally speaking, forest growth can be increased on wood ash–ameliorated peatland rich in nitrogen. On mineral soils, however, no change or even decreased growth have been reported. The effects on ground vegetation are not very clear, as well as the effects on fungi, soil microbes, and soil‐decomposing animals. The discrepancies between different studies are for the most part explained by abiotic factors such as variation in fertility among sites, different degrees of stabilization, and wood ash dosage used, and different time scales among different studies. The lack of knowledge in the field of aquatic ecosystems and their response to ash application is an important issue for future research. The few studies conducted have mainly considered changes in water chemistry. The biotoxic effects of ash application can roughly be divided into two categories: primary and secondary. Among the primary effects is toxicity deriving from compounds in the wood ash and cadmium is probably the worst among these. The secondary effects of wood ash are generally due to its alkaline capacity and a release of ions into the soil and soil water, and finally, watercourses and lakes. Given current knowledge, we would recommend site‐ and wood ash–specific application practices, rather than broad and general guidelines for wood ash application to forests.
|
|
| 10. |
|
|
| 11. |
- Aronsson, K. Andreas
(författare)
-
Effects of wood ash on freshwater organisms and aquatic forest ecosystems
- 2007
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Wood ash application (WAA) has been recommended mainly for two reasons; i) to avoid depletion of minerals in the soil due to whole tree harvest in the forestry and ii) to mitigate harmful effects of acidification of soil and surface waters. In conclusion, the effects on terrestrial ecosystems and, especially, tree growth, can be attributed to the properties of the ash, the dose applied and the specific site at which the ash is applied. The research conducted on the effects of WAA on limnological ecosystems is very limited, and the major purpose of the present thesis was to gain knowledge of the effects of wood ash to different freshwater organisms, and the more comprehensive, limnological effects of WAA in the first stream in Bispgården, Sweden. Effects of wood ash solutions on the unicellular alga Euglena gracilis Klebs, the amphipod Gammarus pulex L., and the moss Fontinalis antipyretica Hedw. were investigated under laboratory conditions. Common in all three species was the decline in performance (growth/velocity/respiration/oxygen evolution) when the concentration of wood ash exceeded 5 g/l and no adjustment of pH was done (alkaline solution). In contrast, different movement parameters (motility, upwards swimming and velocity) in E. gracilis (neutral conditions), and increased growth of F. antipyretica with increased concentrations of wood ash indicated that nutrients in the ash was bioavailable for these organisms. There was no evidence of toxic effects on the organisms from metals or other compounds as a result from exposure to wood ash solutions in the present studies. The field study was conducted in a forest area close to Bispgården, about 100 km NW from Sundsvall, Sweden. The catchment area (50 ha) of the stream Fanbergsbäcken was treated with wood ash in September of 2004 (3,000 kg/ha;selfhardened crush-ash). In general, both biological (diatoms) and chemical (pH, alkalinity, and aluminum (Al) measurements) indicators have shown no significant effect on acidification parameters from the addition of wood ash. There was, however, evidence of an increased pH during spring flood, accompanied with a decrease in the frequency of low pH values (<5.6) during spring flood. In addition to this, alkalinity was significantly higher in the period 2005-2006, compared to that of 2003. High concentrations of toxic forms of Al repeatedly occured in the stream Fanbergsbäcken, and the WAA did not affect the frequencies of high concentrations of toxic Al forms (<50 μg/l). Both the moss F. antipyretica and the leaves from Alnus incana displayed increased potassium (K) concentrations, although other nutrients did not increase from WAA. In conclusion, no evidence of WAA being effective in restoring or improving the ecological status of freshwater environments has been established, either in the literature or in the present field study. On the other hand, there were no indications of harmful effects due to WAA, either. However, we still do not know the effects of wood ash on several organisms (predominantly invertebrates) inhabiting small ponds and other, temporary or permanent, freshwater ecosystems. In the context of WAA, these environments and organisms have not attended any attention in the research published to date, and future studies are strongly encouraged.
|
|
| 12. |
- Aronsson, K. Andreas, et al.
(författare)
-
Effects on growth, photosynthesis and pigments of the freshwater moss Fontinalis antipyretica Hedw. after exposure to wood ash solution
- 2006
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 372:1, s. 236-246
-
Tidskriftsartikel (refereegranskat)abstract
- The application of wood ash from biofuel sources to the forest has been suggested as a source of nutrients for trees and for restoration of acidified soils and surface waters. Studies on the effects of wood ash on aquatic organisms and ecosystems are, however, few. This study investigated the effects of wood ash (0.1 - 10 g l-1) on the freshwater moss Fontinalis antipyretica Hedw., which has previously been shown to be a sensitive test organism for assessing environmental pollution. After nine weeks of treatment with wood ash, a significant effect of enhanced stem growth was observed at the higher concentrations (1 � 10 g l-1). The concentration of wood ash was also correlated to the growth of secondary branches. Photosynthesis (oxygen evolution after 4 h of exposure to wood ash) was significantly lower in the alkaline treatments (no pH adjustment) compared to the treatments with neutral wood ash solutions (pH adjusted to 7.5). Furthermore, photosynthesis in the alkaline wood ash treatments was significantly lower compared to the control. The ratio between the optical density value before and after acidification (OD665/665a) was higher for all wood ash concentrations compared to the control. The OD665/665a values ranged from 1.52 to 1.61 and there was a difference, however not significant, between the alkaline and the neutral treatment at 10 g l-1 wood ash. This study clearly demonstrated that wood ash may be beneficial for F. antipyretica at moderate concentrations (0.5 - 5 g l-1), particularly when sudden increase in pH is avoided.
|
|
| 13. |
- Aronsson, K. Andreas, et al.
(författare)
-
Effects on Motile Factors and Cell Growth of Euglena gracilis After Exposure to Wood Ash Solution : Assessment of Toxicity, Nutrient Availability and pH-Dependency
- 2005
-
Ingår i: Water, Air and Soil Pollution. - : Springer Science and Business Media LLC. - 0049-6979 .- 1573-2932. ; 162:1-4, s. 353-368
-
Tidskriftsartikel (refereegranskat)abstract
- Wood ash application (WAA) to the forest has been suggested as a resource of nutrients for trees and for restoration of acidified soils and surface waters. However, studies of the effects of WAA on aquatic systems are few. This study investigated the effects of wood ash (1-25 g L-1) on the unicellular flagellate Euglena gracilis, which has been proved to be a sensitive test organism for assessing environmental change. Long-term (7 days) growth studies and short-term (direct, 24 and 48 h) studies of different motile factors, using the automatic biological test system Ecotox, were conducted. The results show no indication of biotoxic effects due to wood ash (adjusted to neutral) treatments. However, when no adjustments of pH in wood ash solutions were made, inhibitory effects on motile factors and cell growth were observed at higher concentrations of wood ash (10-25 g L-1) due to high pH (> 8). In tests with pH adjusted to neutral, enhanced motility was observed. These results indicate that high concentration of WAA could affect freshwater environments.
|
|
| 14. |
- Aronsson, K. Andreas, et al.
(författare)
-
Limnological effects on a first order stream after Wood Ash Application to a boreal forest catchment in Bispgården, Sweden
- 2008
-
Ingår i: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 255:1, s. 245-253
-
Tidskriftsartikel (refereegranskat)abstract
- In Sweden, whole tree harvest is common practice, possibly leading to the depletion of mineral nutrients. Furthermore, the increased use of forestry residues for heat production has caused an increasingly growing amount of by-product consisting of wood ash. Therefore, the Swedish Forest Agency has recommended wood ash application (WAA) to replace the mineral nutrients removed by whole tree harvesting, as well as a means to mitigate the acidification of boreal forests and surface waters. In a multidisciplinary study during 2003-2006 in Bispgarden (Sweden), we have investigated the limnological effects on a first order stream after WAA (conducted in 2004; 3000 kg ha-1) to a 50-ha forested catchment. In general, no significant effects on an annual basis were found for acidification parameters, such as pH, alkalinity and toxic forms of aluminum (Al). There was, however, evidence of an increased pH during the spring flood, accompanied by a simultaneous decrease in the frequency of low pH-values (<5.6). Moreover, alkalinity increased in the years 2005 and 2006 compared to that of 2003, although the increase in 2006 was not statistically different from that in 2005 or 2003. High concentrations of Al repeatedly occurred in the stream, and the WAA did not affect the frequencies of high concentrations of toxic Al forms (>50 μg 1-1). The benthic diatom community did not change as a result of the wood ash treatment and the diatom-based index IPS (Indice de PulluoSensibilité) indicated no nutrient enrichment or organic pollution of the stream water. There were, however, indices of elevated concentrations of potassium (K) in the aquatic moss Fontinalis antipyretica and in leaves from Alder (Alnus incana). We conclude that wood ash treatment of a forested catchment with the dose and form of ash applied in this study did not modify the freshwater ecosystem of a first order stream.
|
|
| 15. |
- Aronsson, K. Andreas, et al.
(författare)
-
Respiration measurements can assess the fitness of Gammarus pulex (L.) after exposure to different contaminants : experiments with wood ash, cadmium and aluminum
- 2005
-
Ingår i: Archiv für Hydrobiologie. - : Schweizerbart. - 0003-9136. ; 164:4, s. 479-491
-
Tidskriftsartikel (refereegranskat)abstract
- Wood ash application has been suggested as a means to mitigate acidification of surface waters. However little is known about the effects of wood ash to freshwater organisms. A Clark-type oxygen electrode was used to investigate the effects of wood ash, cadmium and aluminum on the respiration of the freshwater amphipod Gammarus pulex (L.). Harmful effects following wood ash addition were primarily found to be explained by elevated pH. At high concentrations (> 1 g/l) of wood ash the respiration of G. pulex decreased when no adjustment of pH was made, a response that was negatively correlated to the elevated pH (r = -0.43). An ion-related response was also detected in the pH-adjusted (pH 7) tests, although it was not statistically significant. Cadmium proved to be sublethal in the range of 0.2-0.4mg/l in a 24-h exposure. Mortality was 100% at 0.5 and 1.0mg Cd/l. No effects were detected after exposure to Al, due to the high pH (pH 7-8) of the solutions and the subsequently low concentrations of labile monomeric Al. We demonstrate that the method described in this paper could be a useful probe for the detection of sublethal concentrations of contaminants in freshwater ecosystems.
|
|
| 16. |
- Beyerlein, Andreas, et al.
(författare)
-
Intake of Energy and Protein is Associated with Overweight Risk at Age 5.5 Years : Results from the Prospective TEDDY Study
- 2017
-
Ingår i: Obesity. - : Wiley. - 1930-7381. ; 25:8, s. 1435-1441
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The associations of energy, protein, carbohydrate, and fat intake with weight status up to the age of 5.5 years were prospectively assessed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: Food record data (over 3 days) and BMI measurements between 0.25 and 5.5 years were available from 5,563 children with an increased genetic risk for type 1 diabetes followed from shortly after birth. Odds ratios (ORs) were calculated for overweight and obesity by previous intake of energy, protein, carbohydrate, and fat with adjustment for potential confounders. Results: Having overweight or obesity at the age of 5.5 years was positively associated with mean energy intake in previous age intervals (e.g., adjusted OR [95% CI] for overweight: 1.06 [1.04-1.09] per 100 kcal intake at the age of 4.5-5.0 years) and with protein intake after the age of 3.5 and 4.5 years, respectively (e.g., adjusted OR for overweight: 1.06 [1.03-1.09] per 1% of energy intake at the age of 4.5-5.0 years). The respective associations with carbohydrate and fat intake were less consistent. Conclusions: These findings indicate that energy and protein intake are positively associated with increased risk for overweight in childhood but yield no evidence for potential programming effects of protein intake in infancy.
|
|
| 17. |
-
Comparing : National Museums, Territories, Nation-Building and Change. NaMu IV, Linköping University, Norrköping, Sweden 18–20 February 2008
- 2008
-
Proceedings (redaktörskap) (refereegranskat)abstract
- In earlier conferences of NaMu: Making National In earlier conferences of NaMu: Making National Museums, we have explored the complexity of defining National Museums laboured with contemporary narrative analyses and dealt specifically with how diversity and difference are negotiated in an increasingly globalized world. Seewww.namu.se andwww.ep.liu.se/ecp_home/index.en.aspx?issue=022.The fourth conference in the series held at Linköping University 18-20 February 2008 took an explicit historical and comparative outlook dealing with some of the main questions of the NaMu program, stressing methodological issues and comparative strategies. Eight thematic sessions were introduced by seminal key-notes giving European, global and methodological feeds to the dialogue over disciplinary and national borders:Comparing relationships between different forms of national museums and their related academic disciplines. To what extent were and are they part of institutions of knowledge? Do they present a coherent approach to memory politics? To what extent are there autonomous logics operating in the evolution of cultural, historical, technical, natural and art national museums?Comparing the narratives told in and by museums: how do they evolve over time? What “us” and what “others” were constructed with what means? Do they differ between countries structurally?Comparing the role of national museums in the overall history of their setting (relating to disciplinary, esthetical, political and economical developments. Are they forming nations, creating hegemony, arguing for change, disrupting order or integrate?Some answers and the basis for more intelligent questions are to be found in this volume.
|
|
| 18. |
|
|
| 19. |
- Damén, Tor, et al.
(författare)
-
Effects of different mean arterial pressure targets on plasma volume, ANP and glycocalyx-A randomized trial.
- 2021
-
Ingår i: Acta anaesthesiologica Scandinavica. - : Wiley. - 1399-6576 .- 0001-5172. ; 65:2, s. 220-227
-
Tidskriftsartikel (refereegranskat)abstract
- Arterial haematocrit (Hct) has been shown to decrease after anaesthesia induction, most probably because of an increased plasma volume (PV). The primary objective was to quantify change in PV if mean arterial pressure (MAP) was kept at baseline level or allowed to decrease to 60mm Hg. Our secondary objective was to evaluate underlying mechanisms of this response.Twenty-four coronary artery bypass patients were randomized to a higher (90mm Hg, intervention group) or lower (60mm Hg, control group) MAP by titration of norepinephrine. During the experimental procedure, no fluids were administered. Baseline PV was measured by 125 I-albumin and the change in PV was calculated from the change in Hct. Changes in MAP, plasma 125 I-albumin, colloid osmotic pressure, albumin, Mid Regional-pro Atrial Natriuretic Peptide (MR-proANP) and endothelial glycocalyx components were measured from baseline to 50minutes after anaesthesia induction.The MAP during the trial was 93±9mm Hg in the intervention group and 62±5mm Hg in the control group. PV increased with up to 420±180mL in the control group and 45±130mL in the intervention group (P<.001). Albumin and colloid osmotic pressure decreased significantly more in the control group. MR-proANP increased in the control group but no shedding of the glycocalyx layer was detected in either of the groups.Allowing mean arterial pressure to fall to 60mm Hg during anaesthesia induction, increases the plasma volume due to reabsorption of interstitial water, with no ANP-induced degradation of the endothelial glycocalyx.
|
|
| 20. |
- Edberg, Andreas, 1974-, et al.
(författare)
-
Endocervical swabs transported in first void urine as combined specimens in the detection of Mycoplasma genitalium by real-time PCR
- 2009
-
Ingår i: Journal of Medical Microbiology. - : Microbiology Society. - 0022-2615 .- 1473-5644. ; 58, s. 117-120
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine whether a patient’s endocervical swab specimen can be transported in first void urine (FVU) as combined specimens for the detection of Mycoplasma genitalium by real-time PCR. The study also compared two different DNA extraction methods for observation of possible PCR inhibition. Three specimens, one endocervical swab specimen transported in 2-SP medium, one endocervical swab specimen transported in FVU and a FVU specimen, were collected from 329 women. All sample types underwent manual DNA extraction whereas in the DNA extraction study, 329 endocervical swab specimens transported in FVU were subjected to both manual Chelex and automated BioRobot M48 DNA extraction. A total of 100 endocervical swab specimens transported in FVU from patients PCR-negative for M. genitalium in the study were used in the PCR inhibition analysis. M. genitalium was detected in 25/329 (7.6 %) women. The endocervical swab specimens transported in 2-SP medium and transported in FVU were positive for M. genitalium in 17/25 (68 %) and 24/25 (96 %) women, respectively. The FVU specimens alone were positive for M. genitalium in 22/25 (88 %) women. In the DNA extraction study, M. genitalium DNA was detected in 24/329 (7.3 %) and 28/329 (8.5 %) of endocervical swab specimens transported in FVU subjected to manual Chelex extraction and automated BioRobot M48 extraction, respectively. Partial PCR inhibition was detected in 6% of samples subjected to manual Chelex extraction whereas no inhibition was detected with the automated BioRobot M48 extraction. Thus endocervical swab specimens transported in FVU demonstrate higher sensitivity than FVU specimens only and have considerably increased sensitivity compared with endocervical swab specimens transported in 2-SP medium for detection of M. genitalium DNA. Moreover, automated BioRobot M48 extraction was shown to be superior to a crude manual Chelex extraction, leaving no PCR inhibition and giving a slightly higher DNA yield and/or better sensitivity.
|
|
| 21. |
- Ekelund, Nils, et al.
(författare)
-
Changes in chlorophyll a fluorescence in Euglena gracilis and Chlamydomonas reinhardtii after exposure to wood-ash.
- 2007
-
Ingår i: Environmental and Experimental Botany. - : Elsevier BV. - 0098-8472 .- 1873-7307. ; 59:1, s. 92-98
-
Tidskriftsartikel (refereegranskat)abstract
- Recycling of wood-ash to boreal forests has been suggested to prevent depletion of essential soil nutrient or reduce the negative effects of acidification of surface waters. This study investigated the effects of different concentrations of wood-ash (5, 10 and 12.5 mg l-1 diluted in cultivating medium) on chlorophyll a fluorescence in Euglena gracilis and Chlamydomonas reinhardtii. The green alga C. reinhardtii was more susceptible to wood-ash solutions than the flagellate E. gracilis. Two different forms of wood-ash solutions were tested. In the first solution no adjustment of pH was made. In the second, the pH was adjusted to 7. Wood-ash forms a very strong alkaline reaction if no adjustment of pH is made. The results show that no negative effect on fluorescence yield, electron transport rate (ETR), photochemical quenching (qP) or non-photochemical quenching (NPQ) was observed in E. gracilis. In contrast, C. reinhardtii displayed strong inhibition at concentrations of 10 and 12.5 mg l-1 with non-adjusted pH. The negative effects of high pH on the photosynthetic capacity in C. reinhardtii could either be related to the destruction of the ∆pH across the thylakoid or other parts in the photosynthetic systems that are negatively affected by changing pH. Elevated pH levels in aquatic ecosystems constitute a major environmental stress factor to the phytoplankton community and may lead to loss of diversity among primary producers. If wood-ash application was to become general practice in or near aquatic ecosystems the ash may need to be treated accordingly to avoid rapid changes in pH.
|
|
| 22. |
- Ekelund, Nils, et al.
(författare)
-
Flagellaten Euglena gracilis rörelseförmåga kan avslöja graden av giftighet (kadmium) i vatten med hjälp av metoden ECOTOX. (Orientation of the flagellate Euglena gracilis can identify the toxicity (cadmium) of water using the automatic biotest ECOTOX).
- 2004
-
Ingår i: Vatten. - 0042-2886. ; 60:2, s. 77-84
-
Tidskriftsartikel (refereegranskat)abstract
- The interest in testing of water and wastewater for toxic compounds has increased in the last few years with rising pollutant levels from industry and with rising sensibility towards environmental problems. In order to get an early warning signal of environmental conditions the use of unicellular organism are recommended since they respond quickly and are easy to handle. An early warning system, called ECOTOX, for monitoring of water quality has been developed by a research group in Germany (Prof. D.-P. Häder). ECOTOX use movement parameters of the flagellate Euglena gracilis as orientation in the gravity field, the motility and the velocity of the cells. These parameters have been found to be sensitive to toxic compounds. In the present study it was shown that cadmium affect gravitaxis, motility, velocity and compactness of the cells negatively in the concentration interval of 10 to 15 mg l-1 after 24 and 48 h. After short time of incubation (minutes) with cadmium there is an inhibition of the different movements parameters starting at the concentration of 25 mg l-1. Like other biomonitoring systems ECOTOX can be used to detect changes in quality of aquatic systems.
|
|
| 23. |
- Fritzson, Peter, 1952-, et al.
(författare)
-
Modelica - A Strongly Typed System Specification Language for Safe Engineering Practices
- 2004
-
Ingår i: Proceedings of the SimSAFE Conference, Karlskoga, Sweden, June 15-17, 2004.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Recent years have witnessed a significant growth of interest in modeling and simulation of engineering application systems. A key factor in this growth has been the development of efficient equation-based simulation languages, with Modelica as one of the prime examples. Such languages have been designed to allow automatic generation of efficient simulation code from declarative specifications. A major objective is to facilitate reuse and exchange of models, model libraries, and simulation specifications.The Modelica language and its associated support technologies have achieved considerable success through the development of domain libraries in a number of technical areas. By using domain-libraries complex simulation models can be built by aggregating and combining submodels and components from various physical domains.The concept of safe engineering practices has been one of the most important guidelines when designing Modelica. This made it natural to make Modelica a statically strongly typed language, which allows the compiler to check the consistency of a design before it is executed, in contrast to dynamically typed languages such as Matlab.The ability of static checking has also influenced the design of conditional equations and the ongoing the design of variant handling features in Modelica. Moreover, the language allows support for standardized physical units, thus enabling tools for unit checking of relationships and connections between interfaces. A third possible level of checking is through design rules within application-specific libraries, which can be enforced via assert statements. These properties taken together gives a good foundation for safe engineering practices, even though more work is needed to further increase the safety quality level.
|
|
| 24. |
- Fritzson, Peter, et al.
(författare)
-
The Open Source Modelica Project
- 2002
-
Ingår i: Proceedings from The 2nd International Modelica Conference was held March 18-19, 2002, Oberpfaffenhofen, Germany. - : Modelica Association. ; , s. 297-306
-
Konferensbidrag (refereegranskat)abstract
- The open source software movement has received enormous attention in recent years. It is often characterized as a fundamentally new way to develop software. This paper describes an effort to develop an open source Modelica environment to a large extent based on a formal specification of Modelica, coordinated by PELAB, Department of Computer and Information Science, Linköping University, Sweden. The current version of the system provides an efficient interactive computational environment for most of the expression, algorithm, and function parts of the Modelica language as well as an almost complete static semantics for Modelica 2.0.The longer-term goal is to provide reasonable simulation execution support, at least for less complex models, also for the equation part of Modelica which is the real essence of the language. People are invited to contribute to this open source project, e.g. to provide implementations of numerical algorithms as Modelica functions, add-on tools to the environment, or contributions to compiler itself. The source code of the tool components of the open source Modelica environment is available under the Gnu Public License, GPL. The library components are available under the same conditions as the standard Modelica library. The system currently runs under Microsoft Windows, Linux, and Sun Sparc Solaris. A benchmark example of running a simplex algorithm shows that the performance of the current system is close to the performance of handwritten C code for the same algorithm.
|
|
| 25. |
- Fursatz, Marian, et al.
(författare)
-
Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine
- 2018
-
Ingår i: Biomedical Materials. - : Institute of Physics Publishing (IOPP). - 1748-6041 .- 1748-605X. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- Wound dressings based on bacterial cellulose (BC) can form a soft and conformable protective layer that can stimulate wound healing while preventing bacteria from entering the wound. Bacteria already present in the wound can, however, thrive in the moist environment created by the BC dressing which can aggravate the healing process. Possibilities to render the BC antimicrobial without affecting the beneficial structural and mechanical properties of the material would hence be highly attractive. Here we present methods for functionalization of BC with ε-Poly-L-Lysine (ε-PLL), a non-toxic biopolymer with broad-spectrum antimicrobial activity. Low molecular weight ε-PLL was cross-linked in pristine BC membranes and to carboxymethyl cellulose (CMC) functionalized BC using carbodiimide chemistry. The functionalization of BC with ε-PLL inhibited growth of S. epidermidis on the membranes but did not affect the cytocompatibility to cultured human fibroblasts as compared to native BC. The functionalization had no significant effects on the nanofibrous structure and mechanical properties of the BC. The possibility to functionalize BC with ε-PLL is a promising, green and versatile approach to improve the performance of BC in wound care and other biomedical applications.
|
|
| 26. |
- Gårdstedt-Berghog, Jenni, et al.
(författare)
-
Timing of menarche and pubertal growth patterns using the QEPS growth model
- 2024
-
Ingår i: Frontiers in Pediatrics. - 2296-2360. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: To explore the timing of menarche, postmenarcheal growth, and to investigate the impact of various variables on menarcheal age and postmenarcheal and pubertal growth. Study Design: This longitudinal community population-based study analyzed pubertal growth and menarcheal age in 793 healthy term-born Swedish girls, a subset of the GrowUp1990Gothenburg cohort. The timing of menarche and postmenarcheal growth was related to variables from the Quadratic-Exponential-Pubertal-Stop (QEPS) growth model, birth characteristics, and parental height. Multivariable models were constructed for clinical milestones; at birth, age 7 years, pubertal growth onset, and midpuberty. Results: Menarche aligned with 71.6% (18.8) of the QEPS model's specific pubertal growth function, at a mean age of 13.0 (1.3) years, ranging from 8.2 to 17.2 years. Postmenarcheal growth averaged 8.0 (4.9) cm, varying widely from 0.2 to 31.1cm, decreasing with later menarche. Significant factors associated with menarcheal age included height at 7 years, childhood body-mass index, parental height, and QEPS-derived pubertal growth variables. Multivariable models demonstrated increasing explanatory power for each milestone, explaining 1% of the variance in menarcheal age at birth, 8% at age 7 years, 44% at onset of pubertal growth, and 45% at midpuberty. Conclusions: This study underscores the strong link between pubertal growth and age at menarche. Data available at start of puberty explain 44% of the variation in menarcheal age, apparent on average 3.2 years before menarche. In addition, the study shows a previously seldom noticed wide variation in postmenarcheal height gain from 0.2 to 31.1cm.
|
|
| 27. |
- Hummel, Sandra, et al.
(författare)
-
First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study
- 2017
-
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 40:3, s. 398-404
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding 3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow'smilk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D .
|
|
| 28. |
- Koletzko, Sibylle, et al.
(författare)
-
Caesarean Section on The Risk of Celiac Disease in the Offspring : The Teddy Study
- 2018
-
Ingår i: Journal of Pediatric Gastroenterology and Nutrition. - 0277-2116. ; 66:3, s. 417-424
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:: Caesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS:: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental Determinants for Diabetes in the Young (TEDDY) study. Children were annually screened for transglutaminase autoantibodies, if positive re-tested after 3–6 months and those persistently positive defined as CDA. Associations of C-section with maternal (age, education level, parity, pre-pregnancy weight, diabetes, smoking, weight gain during pregnancy) and child characteristics (gestational age, birth weight) were examined by Fisherʼs exact test or Wilcoxon rank-sum test. Hazard ratios (HRs) for CDA or CD were calculated by Cox proportional hazard regression models. RESULTS:: Of 6,087 analyzed singletons 1600 (26%) were born by C-section (Germany 38%, US 37%, Finland 18%, Sweden 16%), the remaining vaginally without instrumental support; 979 (16%) had developed CDA and 343 (6%) CD. C-section was associated with lower risk for CDA (HR?=?0.85, [95% CI 0.73, 0.99], p?=?0.032) and CD (HR?=?0.75, [95% CI 0.58, 0.98], p?=?0.034). After adjusting for country, sex, HLA-genotype, CD in family, maternal education and breastfeeding duration, significance was lost for CDA (HR?=?0.91, [95% CI 0.78, 1.06], p?=?0.20) and CD (HR?=?0.85, [95% CI 0.65, 1.11], p?=?0.24). Pre-surgical ruptured membranes had no influence on CDA or CD development. CONCLUSION:: C-section is not associated with increased risk for CDA or CD in the offspring.
|
|
| 29. |
- Kölby, Lars, 1963, et al.
(författare)
-
Can quantification of VMAT and SSTR expression be helpful for planning radionuclide therapy of malignant pheochromocytomas?
- 2006
-
Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923. ; 1073, s. 491-7
-
Tidskriftsartikel (refereegranskat)abstract
- Tumor-specific uptake of the radio-iodinated norepinephrine analogue meta-iodobenzylguanidine (MIBG) or uptake of radiolabeled somatostatin analogues via somatostatin receptors (SSTRs) are possibilities to diagnose and treat malignant pheochromocytomas/paragangliomas (PCs/PGs). The aims of this study were to investigate the quantitative expression of vesicular monoamine transporters (VMAT 1, 2) and all five SSTRs in malignant pheochromocytoma/paraganglioma (PC/PG) to evaluate the possibilities for tumor-specific radionuclide therapy. High scintigraphic 123I-MIBG uptake was found in two malignant PGs with high VMAT expression (500-730 copies of VMAT 1, 1,500-1,700 copies of VMAT 2 per 1,000 beta-actin), while no 123I-MIBG uptake was found in the malignant PG with low VMAT expression (330 copies of VMAT 1, 350 copies of VMAT 2 per 1,000 beta-actin). The two patients with high VMAT expression and high 123I-MIBG uptake were treated with 131I-MIBG (2-3x8 GBq). In vitro, the VMAT antagonist, reserpine, and the membrane pump inhibitor, clomipramine, inhibited the uptake of 123I-MIBG into tumor cells equally well (48% and 53% reduction respectively, P<0.001). SSTR2 was the most abundant receptor subtype, but in the two malignant PGs its expression was only 110-260 copies/1,000 beta-actin. The transporters at the cell membrane and in the vesicular membrane both appear to be of importance for the uptake of 123I-MIBG into malignant PC/PG. Quantitative determination of VMAT expression may be helpful in selecting patients suitable for radionuclide therapy with 131I-MIBG. The present data indicate that SSTR-mediated radionuclide therapy will not be effective treatment of malignant PC/PG.
|
|
| 30. |
- Lundgren, Markus, et al.
(författare)
-
Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
- 2017
-
Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 17:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.
|
|
| 31. |
|
|
| 32. |
- Norrman, Andreas, et al.
(författare)
-
Analysis of the Software supply chain from a logistics control point of view
- 2004
-
Ingår i: Challenging boundaries with logistics : proceedings of the 16th Annual Conference for Nordic Researchers in Logistics : NOFOMA 2004, 7-8 June, Linköping, Sweden. - 9173739855 ; , s. 551-567
-
Konferensbidrag (refereegranskat)abstract
- In industries like high-tech and automotive, increasingly more of the product value delivered to the customer is based on a combination of hardware (HW) and software (SW), where SW handles much of the differentiation of capacity and features. The “logistics process” of SW, especially when it merges with HW along the process, has so far been little studied but a problem noticed is the difficulties to control and track the SW flow (e.g. Patton 1998, Pollit 1999, Baxter 2001). Based on a telecom case study (Ericsson) this paper describes and analyses their SW’s “customer order-to-use” process and the related control process, using a “logistics framework”. The case illustrates “supply chain issues” related to SW in general and control in particular. It is shown both similarities and differences compared to traditional HW "logistics flows". The SW supply chain is, as for HW, also characterized by e.g. the importance of short lead time, delivery accuracy, outsourcing. But the intangible nature of SW, and the need to know what SW and HW the customer uses also after the product is sold, is some differences.
|
|
| 33. |
|
|
| 34. |
- Pitchika, Anitha, et al.
(författare)
-
Associations of Maternal Diabetes During Pregnancy with Overweight in Offspring : Results from the Prospective TEDDY Study
- 2018
-
Ingår i: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 26:9, s. 1457-1466
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: This study aimed to determine the relationship between different forms of, and potential pathways between, maternal diabetes and childhood obesity at different ages. Methods: Prospective cohort data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which was composed of 5,324 children examined from 0.25 to 6 years of age, were analyzed. Cross-sectional and longitudinal analyses taking into account potential confounders and effect modifiers such as maternal prepregnancy BMI and birth weight z scores were performed. Results: Offspring of mothers with gestational diabetes mellitus (GDM) or type 1 diabetes mellitus (T1DM) showed a higher BMI standard deviation score and increased risk for overweight and obesity at 5.5 years of age than offspring of mothers without diabetes. While these associations could be substantially explained by maternal prepregnancy BMI in offspring of mothers with GDM, significant associations disappeared after adjustment for birth weight z scores in offspring of T1DM mothers. Furthermore, overweight risk became stronger with increasing age in offspring of mothers with diabetes compared with offspring of mothers without diabetes. Conclusions: Maternal diabetes is associated with increased risk of offspring overweight, and the association appears to get stronger as children grow older. Indeed, intrauterine exposure to maternal T1DM may predispose children to later obesity through increased birth weight, while maternal BMI is more important in children exposed to GDM.
|
|
| 35. |
- Schüler, Emil, et al.
(författare)
-
The amount of injected (177)Lu-octreotate strongly influences biodistribution and dosimetry in C57BL/6N mice.
- 2016
-
Ingår i: Acta oncologica (Stockholm, Sweden). - 1651-226X. ; 55:1, s. 68-76
-
Tidskriftsartikel (refereegranskat)abstract
- (177)Lu-octreotate therapy has proven to give favorable results after treatment of patients with neuroendocrine tumors. Much focus has been on the binding and uptake of (177)Lu-octreotate in tumor tissue, but biodistribution properties in normal tissues is still not fully understood, and the effect of receptor saturation may be important. The aim of this study was to investigate the influence of the amount of (177)Lu-octreotate on the biodistribution of (177)Lu-octreotate in normal tissues in mice.
|
|
| 36. |
- Wängberg, Bo, 1953, et al.
(författare)
-
Malignant pheochromocytoma in a population-based study: survival and clinical results.
- 2006
-
Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923. ; 1073, s. 512-6
-
Tidskriftsartikel (refereegranskat)abstract
- One hundred fifty-four consecutive patients with pheochromocytoma (PC, n=137) or paraganglioma (PG, n=17) were treated at our unit. Twenty patients had MEN 2, 15 VRD, and 1 VHL tumors. Twelve had malignant tumors and were classified according to mode of presentation: (1) Distant metastases (n=4); three underwent surgical debulking (with chemotherapy in one); and three had 131I-MIBG therapy. Within 4 years two patients died of tumor progression. (2) Locally advanced disease (n=4), all resected for cure. (3) Malignancy disclosed during follow-up after adrenalectomy with "benign" histopathology (n=4). All patients in groups 2 and 3 developed recurrence 9 (1-17) years after primary surgery; four underwent resection, one remains tumor-free. The others were treated chronically with phenoxybenzamine, combined with 131I-MIBG in one. These eight patients were observed 20 (5-35) years after primary surgery and 11 (1-19) years after recurrence. This series is population-based and may better reflect the natural history of malignant PC/PG than the series from national referral centers. Active surgical treatment and phenoxybenzamine resulted in low tumor-related mortality in groups 2 and 3; five patients died 8-30 years after diagnosis, four of PC/PG (three from group 2 and one from group 3) and one of other causes. We propose tumor uptake studies (MIBG- and octreotide scintigraphy) in patients with nonresectable metastases; to select individual radionuclide therapy data on the expression of CA-transporters/somatostatin receptors may be helpful. To diagnose PC/PG early, screening of adrenal incidentalomas has been suggested. In a regional population-based prospective study, 503 incidentalomas were reported during 18 months, but only one patient with PG was identified.
|
|
