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- Löfqvist, Chatarina, 1964, et al.
(författare)
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Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice
- 2009
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Ingår i: Invest Ophthalmol Vis Sci. - 1552-5783. ; 50:4, s. 1831-1837
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Retinopathy is a result of pathologic angiogenesis influenced by insulinlike growth factor (IGF)-1. The authors examined the local expression of the IGF/insulin family. METHODS: In retinas with and without oxygen-induced retinopathy, the authors assessed with real-time RT-PCR mRNA expression of the IGF-1 receptor (IGF-1R), insulin receptor (IR), IGF-1, IGF-2, insulin (Ins2), and IGF-binding protein 1 (IGFBP1) to IGFBP6 in total retina from postnatal day (P) 7 to P33 to examine changes over time with the induction of retinopathy and at P17 on laser-captured retinal components to quantitatively localize mRNA expression in the ganglion cell layer, the outer nuclear layer, the inner nuclear layer, normal blood vessels, and neovascular tufts. RESULTS: IGF-1R and IR are expressed predominantly in photoreceptors and in vessels, with scant expression in the rest of the neural retina. IGF-1R expression is more than 100-fold greater than IR. The major local growth factor (expressed in photoreceptors and in blood vessels) is IGF-2 (approximately 1000-fold greater than IGF-1). IGF-1 (approximately 600 copies/10(6) cyclophilin) is expressed throughout the retina. IGFBP2, IGFBP4, and IGFBP5 expression is unchanged with increasing retinal development and with the induction of retinopathy. In contrast, IGFBP3 expression increased more than 5-fold with hypoxia, found in neovascular tufts. CONCLUSIONS: IGF-1R, IR, and the ligand IGF-2 are expressed almost exclusively in photoreceptors and blood vessels. IGFBP3 and IGFBP5 expression increases in neovascular tufts compared with normal vessels. IGF-1 is expressed throughout the retina at much lower levels. These results suggest cross-talk between vessels and photoreceptors in the development of retinopathy and retinal vasculature.
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| 6. |
- Holm, U, et al.
(författare)
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Pedagogical methods and affect tolerance in medical students
- 1999
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Ingår i: MEDICAL EDUCATION. - : BLACKWELL SCIENCE LTD. ; 33:1
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objectives There has been little evaluation, by means other than cognitive variables, of medical school curricula that include problem-based learning (PBL). This study aimed to investigate whether medical students' affect tolerance, an important prerequi
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| 7. |
- Holmgren, Daniel, 1945, et al.
(författare)
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Bakjoursutbildning för barnläkare kan stärka patientsäkerheten: Fortbildningsprojekt utvärderas i västra götalandsregionen
- 2016
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Ingår i: Läkartidningen. - 0023-7205. ; 113:10, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- As part of a mandate to provide continuing professional development (CPD) for paediatricians in western Sweden and to support patient safety, we have addressed the professional demands which are imposed on today’s consultant paediatricians on call, by designing and implementing a CPD programme for this group. Learning objectives for specific learning modules were developed from a pre-course needs assessment among consultants. The implemented programme included a variety of learning, assessment and evaluation methods. Each specific learning module began with a reading assignment exploring the key concept. This prepared the participants for the case discussion, in which they would analyse, reflect and achieve a deeper level of understanding. We believe that the educational methods used and the approach of the programme are applicable to specialist training as well as to CPD programmes in general, as part of a lifelong learning process. © 2016, (Publisher). All rights reserved.
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| 8. |
- Olsson, Gustaf, et al.
(författare)
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Operation and Control of Wastewater Treatment - A Scandinavian Perspective over 20 years
- 1998
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Ingår i: Water Science and Technology. - 0273-1223. ; 37:12, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- This paper aims to review the development of wastewater treatment operation and control over the last two decades. Due to the authors' background and experiences there is a special emphasis on the Scandinavian perspective. Since the developments in these countries have been in the forefront in the wastewater treatment area we believe that it may give a reasonable view of the progress also in other countries. The results of regulatory, technical and economical driving forces are discussed. A brief historical review of the progress of nutrient removal is made, and current methodologies for the operation and control of nutrient removal systems is reviewed.
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| 9. |
- Olsson, H., et al.
(författare)
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Increased plasma prolactin levels in a group of men with breast cancer - a preliminary study
- 1990
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Ingår i: Anticancer research. - 0250-7005. ; 10:1, s. 59-62
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Tidskriftsartikel (refereegranskat)abstract
- Gonadal and hypophyseal hormones were investigated in 15 males with breast cancer and 15 tumour referents, on average 1 month postoperatively. Plasma prolactin was found to be significantly more often elevated in men with breast cancer compared with referents (p <0.005). Another group of men with breast cancer disclosed a tendency for lower S-FSH levels compared with the referents (p <0.01). No significant difference was seen between cases and referents regarding S-LH, p-estradiol or p-testosterone. The size of the primary breast tumour was correlated with a higher prolactin level. The findings lend support to a theory implicating prolactin and possibly prolactinomas as a risk factor for the disease in males.
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| 10. |
- Ranstam, J., et al.
(författare)
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Survival in breast cancer and age at start of oral contraceptive usage
- 1991
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Ingår i: Anticancer research. - 0250-7005. ; 11:6, s. 2043-2046
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Tidskriftsartikel (refereegranskat)abstract
- In general, findings in studies on oral contraceptives (OCs) and breast cancer have not indicated prognosis to be worse among users of OCs. In few studies, however, has age at the start of OC usage been considered as a prognostic factor. In the present study prognosis in breast cancer is compared with OC usage particularly with age at the start of OC usage among 193 consecutive patients at the Department of Oncology University Hospital Lund. An earlier series of 193 breast cancer patients at Malmo General Hospital is included for comparisons. In the Lund series five-year survival was 62% among women who started to use OCs before the age of 20, 78% among those who started to use OCs between the ages of 20 and 25, and 86% among non-users and those who started to use OCs after the age of 25 (p = 0.009 test for homogeneity). Although age was found to be a prognostic factor in the Lund series (RR = 0.90, p = 0.001) this was not so in the earlier (older) Malmo series. The relationship with age differed significantly between the two series (p = 0.003) suggesting the apparent effect of age at diagnosis to be a cohort effect due to the introduction of OCs during the sixties. The age-specific relationship between survival and OC usage would seem to indicate the presence of a biological mechanism in which OCs may participate during precancerous and early stages of breast cancer.
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| 11. |
- Ringberg, Anita, et al.
(författare)
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Breast carcinoma in situ in 167 women--incidence, mode of presentation, therapy and follow-up
- 1991
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Ingår i: European Journal of Surgical Oncology. - 1532-2157. ; 17:5, s. 466-476
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Tidskriftsartikel (refereegranskat)abstract
- In the city of Malmo, in southern Sweden, 1693 women were diagnosed as having breast carcinoma during 1976 through 1984. Of these, 167 women had pure in situ breast carcinoma (9.9%). One hundred and thirty-two had ductal carcinoma in situ (DCIS) alone or in combination with lobular carcinoma in situ (LCIS), intracystic carcinoma and/or Paget's disease of the nipple. Thirty-three had pure LCIS and two had pure intracystic carcinomas. The incidence of breast carcinoma in situ (CIS) in women 20 years of age or older was 18.7 per 10(5) woman years with high rates of DCIS for all ages above 40, whereas a decline in incidence rate was seen for LCIS in the postmenopausal age groups. The ratio of DCIS to LCIS was 4:1. Of the 132 patients with DCIS, 46% were asymptomatic and were diagnosed by mammography, 35% presented with clinical symptoms, and 19% of the cases were incidental findings in breasts operated on for benign lesions. Mammography had been performed on all patients with DCIS and contributed to diagnosis in 75%. Sixty-one per cent of all DCIS lesions had microcalcifications suspicious for carcinoma. Eighty-nine of 132 patients with DCIS underwent fine-needle aspiration biopsy (FNAB) before surgical biopsy. FNAB was suspicious or diagnostic for carcinoma in 57/89 (64%). Of 33 cases with LCIS all but one were incidental findings. In one of 28 cases with LCIS examined by mammography there was suspicion of carcinoma. Sixteen per cent of the patients with DCIS were treated by a breast-conserving operation (BCO), the remaining patients by mastectomy (ME) (52%) or subcutaneous mastectomy (SCM) (33%) with immediate reconstruction. Thirty-three per cent of the patients with LCIS were treated by BCO, the remaining patients by ME (18%) or SCM (49%) with immediate reconstruction. Only one patient had radiotherapy postoperatively. In 60% of all CIS cases where an excisional biopsy had been performed there were further foci of CIS in the final ME/SCM specimen. After a median follow-up of 7 years for the DCIS group, three patients out of 21 treated by BCO had invasive carcinoma appearing ipsilaterally. They were alive and without symptoms of recurrent disease 2.5 to 6 years following further surgery. One patient treated by SCM died from generalized ductal breast carcinoma. In the LCIS group (median follow-up 8 years) one patient out of 11 had an invasive tubular carcinoma diagnosed 4 years after BCO. Eight years later she was alive and well after bilateral SCM.
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| 12. |
- Ringberg, Anita, et al.
(författare)
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Immediate breast reconstruction after mastectomy for cancer
- 1999
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Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 1532-2157 .- 0748-7983. ; 25:5, s. 470-476
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: The oncological, surgical and cosmetic results, patient satisfaction and psychological morbidity of immediate breast reconstruction following mastectomy for breast cancer were evaluated. METHODS: From 1980 to 1994, 79 immediate breast reconstructions were performed in Malmo. From 1985 immediate breast reconstruction was performed in 21% of mastectomies among patients
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