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- Sorelius, Karl, et al.
(författare)
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The Microbiology of Infective Native Aortic Aneurysms in a Population-Based Setting
- 2022
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Ingår i: Annals of Vascular Surgery. - : Elsevier. - 0890-5096 .- 1615-5947. ; 78, s. 112-122
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim was to describe the microbiology of surgically treated infective native (mycotic) aortic aneurysms (INAAs), and associated survival and development of infection-related complications (IRCs). Methods: Data were pooled from 2 nationwide studies on surgically treated patients with INAAs in Sweden, between 1994 - 2016. Patients were grouped and analyzed according to culture results: 1) Staphylococcus aureus, 2) Streptococcus species (sp.), 3) Salmonella sp., 4) Enterococcus sp., 5) Gram-negative intestinal bacteria, 6) Other sp. (all other species found in culture), and 7) Negative cultures. Results: A sum of 182 patients were included, mean age 71 years (standard deviation; SD: 8.9). The median follow-up was 50.3 months (range 0 - 360). 128 (70.3%) patients had positive blood and/or tissue culture; Staphylococcus aureus n = 38 (20.9%), Streptococcus sp. n = 37 (20.3%), Salmonella sp. n = 19 (10.4%), Enterococcus sp. n = 16 (8.8%), Gram-negative intestinal bacteria n = 6, (3.3%), Other sp. n = 12 (6.6%) and Negative cultures n = 54 (29.7%). The estimated survival for the largest groups at 2-years after surgery was: Staphylococcus aureus 62% (95% Confidence interval 53.9 - 70.1), Streptococcus sp. 74.7% (67.4 - 82.0), Salmonella sp. 73.7% (63.6 - 83.8), Enterococcus sp. 61.9% (49.6 - 74.2), and Negative cultures 89.8% (85.5 - 94.1), P =.051. There were 37 IRCs (20.3%), and 19 (51.4%) were fatal, the frequency was insignificant between the groups. The majority of IRCs, 30/37 (81%), developed during the first postoperative year. Conclusion: In this assessment of microbiological findings of INAAs in Sweden, 50% of the pathogens were Staphylococcus aureus, Streptococcus sp., or Salmonella sp.. The overall 20%-frequency of IRCs, and its association with high mortality, motivates long-term antibiotic treatment regardless of microbial findings.
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- Vucetic, N, et al.
(författare)
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Diagnosis and prognosis in lumbar disc herniation
- 1999
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Ingår i: Clinical orthopaedics and related research. - : Ovid Technologies (Wolters Kluwer Health). - 0009-921X. ; :361, s. 116-122
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Tidskriftsartikel (refereegranskat)
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- Albrektsson, Tomas, 1945, et al.
(författare)
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Histologic investigations on 33 retrieved Nobelpharma implants.
- 1993
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Ingår i: Clinical materials. - 0267-6605. ; 12:1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Thirty Nobelpharma implants were retrieved from 17 patients despite a remaining clinical stability, after between 1 and 16 years of clinical function. The reasons for implant removal were bone resorption in combination with soft tissue disorders, psychological causes, implant fracture and post mortem cases. When measured at the cortical passage, there was an average of 84.9% direct bone-to-implant contact and 81.8% average surface bone area in individual threads as evaluated in a computerized morphometric system at the light microscopic level.
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- Krarup, Anne L., et al.
(författare)
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Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain.
- 2011
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Ingår i: Alimentary pharmacology & therapeutics. - : Wiley. - 1365-2036 .- 0269-2813. ; 33:10, s. 1113-22
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Tidskriftsartikel (refereegranskat)abstract
- Background Many patients with gastro-oesophageal reflux disease (GERD) are hypersensitive to heat and acid and may respond insufficiently to standard treatment. Antagonists of the heat and acid receptor ‘transient receptor potential vanilloid 1’(TRPV1) are a potential drug class for GERD treatment. Aim To investigate the effect of a TRPV1 antagonist (AZD1386) on experimentally induced oesophageal pain. Methods Twenty-two healthy men (20–31 years) participated in this randomised, placebo-controlled, double-blinded, crossover study examining the effects of a single-dose oral AZD1386 (30 and 95 mg). Subjects were block-randomised. On treatment days, participants were stimulated with painful heat, distension, electrical current and acid in the oesophagus. Heat and pressure pain on the forearm were somatic control stimuli. Data analysis: intention-to-treat. Results A total of 21 participants completed the protocol and 1 voluntarily discontinued. In the oesophagus, both 30 and 95 mg of AZD1386 increased pain thresholds to heat stimuli 23% [95% confidence interval (CI): 10–38%] and 28%, respectively (CI: 14–43%). The skin heat tolerance was increased 2.1 °C (CI: 1.1–3.2 °C) after 30 mg AZD1386 and 4.0 °C (CI: 3.0–5.0 °C) after 95 mg. Heat analgesia persisted for 2.5 h. Pain thresholds to the other stimuli were unaffected by AZD1386. 50% reported ‘feeling cold’ and body temperature increased in all subjects exposed to 30 and 95 mg AZD1386 (mean increase 0.4 ± 0.3 °C and 0.7 ± 0.3 °C, respectively, P < 0.05). Conclusions AZD1386 increased oesophageal and skin heat pain thresholds and had a safe adverse-event profile. This drug class may have a potential for treatment of GERD (ClinicalTrials.gov identifier: NCT00711048).
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- Moritani, T, et al.
(författare)
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Neural and biomechanical differences between men and young boys during a variety of motor tasks.
- 1989
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Ingår i: Acta Physiologica Scandinavica. - 0001-6772 .- 1365-201X. ; 137:3, s. 347-55
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Tidskriftsartikel (refereegranskat)abstract
- The adaptation in activation patterns of the ankle extensor muscles to different functional demands was studied in adult men (n = 10) and 9-year-old boys (n = 10). The relative magnitude of the activation of the slow soleus (SOL) and the relatively fast medial gastrocnemius (MG) muscle was measured during various postures and hopping tasks on a force plate. In addition, the myo-electric activity was quantified in three different phases of the stretch-shortening cycles during hopping. Major differences between boys and adults were observed in the postural tasks, where the boys appeared to utilize the MG to a relatively larger extent. During maximal height hopping there was a clearly larger potentiation of the MG activity in the adults, particularly in the eccentric phase. On the other hand, there were striking similarities between boys and adults with respect to the degree of pre-activation of both muscles during the different hopping regimes as well as potentiation of muscle activity during the concentric phase of maximal height hopping. Thus, some aspects of the selective neural control of the ankle extensor muscles appear to be manifested in pre-pubertal boys. However, the data also indicate that other factors, such as utilization of stored elastic energy in the muscles and stretch reflex potentiation, will still continue to develop from the age of nine.
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- Nordin, Thomas, et al.
(författare)
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Extraoral or intraoral approach in the oblique sliding osteotomy of the mandibular rami? Clinical experience and results.
- 1987
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Ingår i: Journal of Cranio-Maxillofacial Surgery. - 1010-5182 .- 1878-4119. ; 15:5, s. 233-237
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Tidskriftsartikel (refereegranskat)abstract
- The clinical results of oblique sliding (subcondylar) osteotomy of the mandibular rami performed by the extraoral or intraoral approach were compared. The patient material comprised 40 patients with mandibular prognathism. Twenty patients were operated upon using the extraoral approach and 20 patients were operated on using the intraoral approach. All patients had intermaxillary fixation for 7 weeks. The patients in both groups were followed up for 18 months. The experience of the operations was that the intraoral approach gave a shorter operation time than the extraoral approach. The extraoral approach, however, gave better visibility in the operation field and greater possibilities of manipulating the proximal fragment into an optimal position. In the follow-up evaluation, there were no significant differences between the two surgical techniques with regard to dental relapse, post-operative occlusion and mandibular function.
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| 14. |
- Sennerby, Lars, 1960, et al.
(författare)
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Structure of the bone-titanium interface in retrieved clinical oral implants.
- 1991
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Ingår i: Clinical oral implants research. - : Wiley. - 0905-7161. ; 2:3, s. 103-11
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Tidskriftsartikel (refereegranskat)abstract
- 7 clinically stable, "osseointegrated", titanium implants, inserted in human jaws for 1-16 years, were retrieved for morphological analysis of the bone-titanium interface, using 3 different preparation techniques. The bone-titanium interface varied as judged from light microscopy of ground sections. The threads of the implants were well filled (79-95%) with dense lamellar bone as quantified with morphometry. A large fraction of the implant surface (56-85%) appeared to be in direct contact with the mineralized bone. In general, the non-bone areas consisted of pockets with osteocytes, bone marrow tissue and/or vessels. Sections were prepared for light microscopy and transmission electron microscopy using a fracture technique, where the implant was separated from the embedded tissue before sectioning, and an electropolishing technique, where the bulk part of the implant was electrochemically removed. In areas judged as direct mineralized bone-titanium contact in the light microscope, the interfacial structure varied at the ultrastructural level. In areas along the interface, unmineralized tissue was present either as a narrow 0.5-1 micron wide zone containing collagen fibril or as deeper pockets containing osteocytes or vessels. In areas with mineralized bone contact, an amorphous granular layer (100-400 nm wide) with no mineral was observed in the innermost interface bordering the mineralized bone, with an electron-dense lamina limitans-like line (approximately 50 nm thick). It is concluded that the bone-titanium interface of the 7 clinically retrieved titanium oral implants examined in the present study bone was heterogenous. In areas of a direct mineralized bone-titanium contact at the ultrastructural level, mineralized bone reached close to the implant surface, but was separated by an amorphous layer, being 100-400 nm thick.
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