| 1. |
- Sliz, E., et al.
(författare)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 2. |
- Tabassum, R, et al.
(författare)
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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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| 3. |
- Briselet, R., et al.
(författare)
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Production cross section and decay study of Es 243 and Md 249
- 2019
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Ingår i: Physical Review C. - 2469-9985. ; 99:2
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Tidskriftsartikel (refereegranskat)abstract
- In the study of the odd-Z, even-N nuclei Es243 and Md249, performed at the University of Jyväskylä, the fusion-evaporation reactions Au197(Ca48,2n)Es243 and Tl203(Ca48,2n)Md249 have been used for the first time. Fusion-evaporation residues were selected and detected using a gas-filled separator coupled with its focal-plane spectrometer. For Es243, the recoil decay correlation analysis yielded a half-life of 24±3s and a maximum production cross section of 37±10nb. In the same way, a half-life of 26±1s, an α-branching ratio of 75±5%, and a maximum production cross section of 300±80nb were determined for Md249. The decay properties of Es245, the daughter of Md249, were also measured: an α-branching ratio of 54±7% and a half-life of 65±6s. Experimental cross sections were compared to the results of calculations performed using the kewpie2 statistical fusion-evaporation code.
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| 4. |
- Taylor, M. J., et al.
(författare)
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Oblately deformed isomeric proton-emitting state in Lu-151
- 2015
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 91:4
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Tidskriftsartikel (refereegranskat)abstract
- Gamma rays from excited states feeding a proton-emitting isomeric-state in Lu-151 have been observed for the first time. Comparison with state-of-the-art nonadiabatic quasiparticle calculations indicates an oblately deformed, 3/2(+) proton-emitting state with a quadrupole deformation of beta(2) = -0.11. The calculations suggest an increase in quadrupole deformation, to beta(2) = -0.18, with increasing spin which is understood in terms of the mixing of Nilsson states at the Fermi surface. It is also shown that the proton decay half-life is consistent with that from a 3/2(+) state with a quadrupole deformation of beta(2) = -0.12.
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| 5. |
- Gillespie, S. A., et al.
(författare)
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Identification of sub- μ s isomeric states in the odd-odd nucleus Au 178
- 2021
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Ingår i: Physical Review C. - 2469-9985. ; 103:4
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Tidskriftsartikel (refereegranskat)abstract
- The neutron-deficient gold (Z=79) isotopes in the vicinity of the neutron midshell N=104 provide prolific examples of shape coexistence and isomerism at low excitation energy. They can be probed via a number of different experimental techniques. In this study, two new isomeric states with half-lives of 294(7) and 373(9) ns have been observed in the neutron-deficient odd-odd nuclide Au178 (N=99) in an experiment at the RITU gas-filled separator at JYFL, Jyväskylä. This result was achieved due to the use of a segmented planar germanium detector with a high efficiency at low energies. By applying the recoil-decay tagging technique, they were assigned to decay to two different long-lived α-decaying states in Au178.
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| 6. |
- Lewis, M. C., et al.
(författare)
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Decay of a 19(-) isomeric state in Lu-156
- 2018
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 98:2
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Tidskriftsartikel (refereegranskat)abstract
- A multiparticle spin-trap isomeric state having a half-life of 179(4) ns and lying 2601 keV above the yrast 10(+) state in Lu-156 has been discovered. The Lu-156 nuclei were produced by bombarding isotopically enriched Cd-106 targets with beams of Ni-58 ions, separated in flight using the gas-filled separator RITU and their decays were measured using the GREAT spectrometer. Analysis of the main decay path that populates yrast states observed previously suggests a spin-parity assignment of 19(-) for the isomeric state, which is consistent with isomeric states identified in the N = 85 isotones. Comparison with other decay paths in Lu-156 indicates that the [pi h(11/)(2)(-1) circle times nu h(9/2)]10(+) state at the bottom of the yrast sequence is likely to be the a-decaying isomeric state, with the [pi h(11/)(2)(-1) circle times nu f(7/2)]9(+) state lying 62 keV above it. The relative ordering of the lowest-lying 9(+) and 10(+) states is inverted in Lu-156 compared with its odd-odd isotones.
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| 7. |
- Saygi, B., et al.
(författare)
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Reduced transition probabilities along the yrast line in W-166
- 2017
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:2
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of excited states in the yrast band of the neutron-deficient nuclide W-166 have been measured utilizing the DPUNS plunger device at the target position of the JUROGAM II gamma-ray spectrometer in conjunction with the RITU gas-filled separator and the GREAT focal-plane spectrometer. Excited states in W-166 were populated in the Mo-92(Kr-78, 4p) reaction at a bombarding energy of 380 MeV. The measurements reveal a low value for the ratio of reduced transitions probabilities for the lowest-lying transitions B(E2; 4(+)-> 2(+)) / B(E2; 2(+)-> 0(+)) = 0.33(5), compared with the expected ratio for an axially deformed rotor (B-4/2 = 1.43).
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| 8. |
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| 9. |
- Gillespie, S. A., et al.
(författare)
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Identification of a 6.6 μ s isomeric state in Ir 175
- 2019
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Ingår i: Physical Review C. - 2469-9985. ; 99:6
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Tidskriftsartikel (refereegranskat)abstract
- An experiment has been performed to study excited states in the neutron-deficient nucleus Ir175 via the use of the JUROGAM II high-purity germanium detector array and the RITU gas-filled separator at JYFL, Jyväskylä. By using isomer tagging, an isomeric state with a half-life of 6.58(15) μs has been observed in Ir175 for the first time. It has been established that the isomer decays via a 45.2 (E1)-26.1 (M1) keV cascade to new states below the previously reported ground state in Ir175 with Iπ=(5/2-). We now reassign this (5/2-) state to the isomeric state discovered in this study.
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| 10. |
- Parr, E., et al.
(författare)
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Fine structure in the alpha decay of high-spin isomers in Lu-155 and Hf-156
- 2018
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 98:2
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Tidskriftsartikel (refereegranskat)abstract
- Fine structure in the a decay of high-spin isomers in Lu-155( 25/2(-)) and Hf-156(8(+))has been studied for the first time using alpha gamma- coincidence analysis. Three new a decays from Lu-155(25/2(-)) and two from Hf-156(8(+)) have been identified, populating seniority s > 1 states in the N = 82 nuclei Tm-151 and Yb-152, respectively. The reduced hindrance factors of the a decays support the previous configuration assignments of the populated states. This is the first observation of states with excitation energy greater than 1.5 MeV being populated following a decay in nuclei outside of the Pb-208 region.
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| 11. |
- Parr, E., et al.
(författare)
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Single-particle states and parity doublets in odd- Z Ac 221 and Pa 225 from α -decay spectroscopy
- 2022
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Ingår i: Physical Review C. - 2469-9985. ; 105:3
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Tidskriftsartikel (refereegranskat)abstract
- Low-lying states in the odd-Z isotopes Ac13289221 and Pa13491225 have been studied using α-particle and αγ-coincidence spectroscopy in the Pa225→Ac221→Fr217 decay chain. Ground-state spin and parity assignments of Iπ = 5/2- are proposed for both Ac221 and Pa225, with the odd proton occupying the ω = 5/2 orbital of the quadrupole-octupole deformed shell model in both nuclei. In Ac221, excited states in the bands based on the ω = 5/2 and ω = 3/2 orbitals have been identified, including proposed parity-doublet states. The results suggest that reflection-asymmetric deformation of the ground state persists in the odd-A members of the isotope chains down to N = 132 for Ac and N = 134 for Pa, before reaching the transitional region at N = 130.
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| 12. |
- Pereira-López, X., et al.
(författare)
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In-beam γ -ray spectroscopy of 94 Ag
- 2023
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 59:3
-
Tidskriftsartikel (refereegranskat)abstract
- A recoil-beta-tagging experiment has been performed to study the excited T= 0 and T= 1 states in the odd–odd N= Z nucleus 94Ag, populated via the 40Ca(58Ni,1p3n)94Ag reaction. The experiment was conducted using the MARA recoil separator and JUROGAM3 array at the Accelerator Laboratory of the University of Jyväskylä. Through correlating fast, high-energy beta decays at the MARA focal plane with prompt γ rays emitted at the reaction target, a number of transitions between excited states in 94Ag have been identified. The timing characteristics of these transitions confirm that they fall within decay sequences that feed the short-lived T= 1 ground state of 94Ag. The transitions are proposed to proceed within and between the sets of states with T= 0 and T= 1. Possible correspondence between some of these transitions from analog states in 94Pd has been discussed, and shell-model calculations including multipole and monopole electromagnetic effects have been presented, in order to enable predictions of the decay patterns between the T= 0 and T= 1 states and to allow a theoretical set of Coulomb energy differences to be calculated for the A= 94 T= 1 analog states.
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| 13. |
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| 14. |
- Auranen, K., et al.
(författare)
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Experimental study of isomeric intruder 1/2(+) states in At-197,At-203
- 2017
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Ingår i: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 95:4
-
Tidskriftsartikel (refereegranskat)abstract
- A newly observed isomeric intruder 1/2(+) state [T-1/2 = 3.5( 6) ms] is identified in At-203 using a gas-filled recoil separator and fusion-evaporation reactions. The isomer is depopulated through a cascade of E3 and mixed M1/E2 transitions to the 9/2(-) ground state, and it is suggested to originate from the pi(s(1/2))(-1) configuration. In addition, the structures above the 1/2(+) state in At-203 and At-197 are studied using in-beam gamma-ray spectroscopy, recoil-decay tagging, and recoil-isomer decay tagging methods. The 1/2(+) state is fed from 3/2(+) and 5/2(+) states, and the origin of these states are discussed.
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| 15. |
- Auranen, K., et al.
(författare)
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Prompt and delayed spectroscopy of At-203 : Observation of a shears band and a 29/2(+) isomeric state
- 2018
-
Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 97:2
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Tidskriftsartikel (refereegranskat)abstract
- Using fusion-evaporation reactions, a gas-filled recoil separator, recoil-gating technique and recoil-isomer decay tagging technique we have extended the level scheme of At-203 (N = 118) significantly. We have observed an isomeric [tau = 14.1(3) mu s] state with a spin and parity of 29/2(+). The isomeric state is suggested to originate from the pi(h(9/2)) circle times |Po-202; 11(-)> coupling, and it is depopulated through 286 keV E2 and 366 keV E3 transitions. In addition, we have observed a cascade of magnetic-dipole transitions which is suggested to be generated by the shears mechanism.
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| 16. |
- Doncel, Maria, et al.
(författare)
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Lifetime measurements of excited states in W-162 and W-164 and the evolution of collectivity in rare-earth nuclei
- 2017
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 95:4
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of the first excited 2(+) states in the extremely neutron- deficient W-162 and W-164 nuclei have been measured using the recoil distance Doppler shift technique. Experimental B(E2) data for the isotopic chains of hafnium, tungsten, and osmium, from the midshell region near the beta-stability line towards the N = 82 closed shell and the most neutron-deficient nuclides, are compared with predictions of nuclear deformations and 2(1)(+) -> 0(g.s)(.+) reduced transition strengths from different classes of state-of-the-art theoretical model calculations. The results reveal striking differences and deficiencies in the predictive power of current nuclear structure models.
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| 17. |
- Herzáň, A., et al.
(författare)
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Detailed spectroscopy of Bi 193
- 2015
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 92:4
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Tidskriftsartikel (refereegranskat)abstract
- An experiment aiming to study shape coexistence in Bi193 has been performed. Due to its transitional character, it has an exceptionally large number of structures identified close to the yrast line. Many new states have been found, significantly extending the previously known level scheme of Bi193, including several new rotational bands. The πi13/2 band was extended to Iπ=45/2+. The Iπ=31/2+ member of the πi13/2 band was found to de-excite also to a long-lived isomeric state. This isomeric state is located at 2350 keV and has a spin and parity of 29/2+. The half-life of the isomeric state was measured to be 85(3) μs and it decays via the emission of an 84 keV E2 transition. A level structure feeding this isomeric state was constructed. A low-energy, 49 keV transition has been identified to depopulate the (29/2-) isomeric state, which places it at an energy 2405 keV in the level scheme. This is the first time such a decay has been observed in the neutron-deficient Bi isotopes. A superdeformed band almost identical to that present in the neighboring isotope Bi191, based on the 1/2[651] Nilsson orbital, has also been identified.
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| 18. |
- Herzan, A., et al.
(författare)
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Detailed spectroscopy of Bi-195
- 2017
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:1
-
Tidskriftsartikel (refereegranskat)abstract
- An experiment focused on the study of shape coexistence and new high-spin structures in Bi-195 has been performed. The nucleus is in a transitional region of the bismuth isotope chain. A large number of new states have been found, resulting in a significant extension of the previously known level scheme. Several new collective structures have been identified. A strongly coupled rotational band built upon the 13/2(+) isomeric state was extended up to I-pi = (49/2(+)) and an energy of 5706 keV. The I-pi = 31/2(+) member of the pi i(13/2) band was also found to feed a new long-lived isomeric state with an excitation energy of 2616 keV and a spin and parity of I-pi = 29/2(+). The half-life of the 29/2+ isomeric state was determined to be 1.49(1) mu s. It decays via the emission of 457-keV E2 and 236-keV E1 transitions, respectively. A low-energy 46-keV E2 transition has been identified to depopulate the (29/(2-)) isomeric state, with a measured half-life of T-1/2 = 614(5) ns. This transition allows the excitation energy of the isomeric state to be determined as 2381 keV. The feeding patterns of both 29/2(+) and (29/2(-)) isomeric states have also been described. This is the first time collective structures have also been observed up to high spins and excitation energies in the neutron-deficient Bi-195 nucleus. Evidence for the manifestation of shape coexistence in Bi-195 is also discussed.
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| 19. |
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| 20. |
- Kesteloot, N., et al.
(författare)
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Deformation and mixing of coexisting shapes in neutron-deficient polonium isotopes
- 2015
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 92:5
-
Tidskriftsartikel (refereegranskat)abstract
- Coulomb-excitation experiments are performed with postaccelerated beams of neutron-deficient Po-196,Po-198,Po-200,Po-202 isotopes at the REX-ISOLDE facility. A set of matrix elements, coupling the low-lying states in these isotopes, is extracted. In the two heaviest isotopes, Po-196,Po-198, the transitional and diagonal matrix elements of the 2(1)(+) state are determined. In Po-196,Po-198 multistep Coulomb excitation is observed, populating the 4(1)(+), 0(2)(+), and 2(2)(+) states. The experimental results are compared to the results from the measurement of mean-square charge radii in polonium isotopes, confirming the onset of deformation from Po-196 onwards. Three model descriptions are used to compare to the data. Calculations with the beyond-mean-field model, the interacting boson model, and the general Bohr Hamiltonian model show partial agreement with the experimental data. Finally, calculations with a phenomenological two-level mixing model hint at the mixing of a spherical structure with a weakly deformed rotational structure.
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| 21. |
- Li, Hongjie, et al.
(författare)
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First identification of rotational band structures in Re-166(75)91
- 2015
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 92:1
-
Tidskriftsartikel (refereegranskat)abstract
- Excited states in the odd-odd, highly neutron-deficient nucleus Re-166 have been investigated via the Mo-92(Kr-78, 3p1n)Re-166 reaction. Prompt gamma rays were detected by the JUROGAM II. gamma-ray spectrometer, and the recoiling fusion-evaporation products were separated by the recoil ion transport unit (RITU) gas-filled recoil separator and implanted into the Gamma Recoil Electron Alpha Tagging spectrometer located at the RITU focal plane. The tagging and coincidence techniques were applied to identify the gamma-ray transitions in Re-166, revealing two collective, strongly coupled rotational structures, for the first time. The more strongly populated band structure is assigned to the pi h(11/2)[514]9/2(-) circle times vi(13/2)[660]1/2(+) Nilsson configuration, while the weaker structure is assigned to be built on a two-quasiparticle state of mixed pi h(11/2)[514]9/2(-) circle times v[h(9/2)f(7/2)]3/2(-) character. The configuration assignments are based on the electromagnetic characteristics and rotational properties, in comparison with predictions from total Routhian surface and particle-rotor model calculations.
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| 22. |
- Li, Hongjie, et al.
(författare)
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Recoil-decay tagging spectroscopy of W-162(74)88
- 2015
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 92:1
-
Tidskriftsartikel (refereegranskat)abstract
- Excited states in the highly neutron-deficient nucleus W-162 have been investigated via the Mo-92(Kr-78, 2 alpha) W-162 reaction. Prompt gamma rays were detected by the JUROGAM II high-purity germanium detector array and the recoiling fusion-evaporation products were separated by the recoil ion transport unit (RITU) gas-filled recoil separator and identified with the gamma recoil electron alpha tagging (GREAT) spectrometer at the focal plane of RITU. gamma rays from W-162 were identified uniquely using mother-daughter and mother-daughter-granddaughter alpha-decay correlations. The observation of a rotational-like ground-state band is interpreted within the framework of total Routhian surface (TRS) calculations, which suggest an axially symmetric ground-state shape with a gamma-soft minimum at beta(2) approximate to 0.15. Quasiparticle alignment effects are discussed based on cranked shell model calculations. New measurements of the W-162 ground-state alpha-decay energy and half-life were also performed. The observed alpha-decay energy agrees with previous measurements. The half-life of W-162 was determined to be t(1/2) = 990(30) ms. This value deviates significantly from the currently adopted value of t(1/2) = 1360(70) ms. In addition, the alpha-decay energy and half-life of Os-166 were measured and found to agree with the adopted values.
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| 23. |
- Parr, E., et al.
(författare)
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Identification of the J(pi)=1(-) state in Ra-218 populated via alpha decay of Th-222
- 2016
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Ingår i: PHYSICAL REVIEW C. - 2469-9985. ; 94:1
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Tidskriftsartikel (refereegranskat)abstract
- The alpha decay of Th-222 populating the low-lying J(pi) = 3(-) state, and also a proposed 1(-) state, in Ra-218 has been observed. The observations suggest an excitation energy of 853 keV for the 1(-) state, which is 60 keV above the 3(-) state. The hindrance factors of these alpha decays give a possible boundary to the region of ground-state octupole deformation in the light-actinide nuclei. The relative positions of the J(pi) = 1(-) and 3(-) states suggest they are produced by an octupole-vibrational mechanism, as opposed to alpha clustering or rotations of a reflection-asymmetric octupole-deformed shape.
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| 24. |
- Procter, M. G., et al.
(författare)
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Isomer-tagged differential-plunger measurements in Xe-113(54)
- 2013
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 87:1, s. 014308-
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Tidskriftsartikel (refereegranskat)abstract
- The 278-keV M2 gamma decay from the vh(11/2) isomeric state in Xe-113 has been observed for the first time using the recoil-isomer tagging technique. The half-life of the isomer has been measured to be 6.9(3) mu s. The derived B(M2) value is in agreement with the trend of systematic measurements of M2 transition strengths in neutron-deficient tellurium and tin isotopes. The lifetime of the first excited state in the vh(11/2) band has been measured using the recoil distance Doppler-shift method. The extracted B(E2) value has been compared to theoretical CD-Bonn calculations and recent lifetime measurements in Te-109. This comparison of B(E2) values has been used to shed light on the possible influence of collective degrees of freedom on M2 transition strengths in the most neutron-deficient xenon nuclei. The vh(11/2) band is deduced to have a degree of deformation comparable with the ground-state bands of the even-mass xenon isotopes. However, the value deduced in this work indicates a loss of collective behavior when compared with the lower-mass Te-109. This result suggests that, while changes in deformation may be partly responsible for the observed trend in B(M2) values for increasing Z, other effects may also be present.
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| 25. |
- Taylor, M. J., et al.
(författare)
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Competing single-particle and collective states in the low-energy structure of I-113
- 2013
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 88:5, s. 054307-
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Tidskriftsartikel (refereegranskat)abstract
- To understand the low-energy structure of the neutron deficient iodine isotopes, lifetimes for the low-lying 9/2(+) and 11/2(+) positive-parity states in I-113 have been measured as tau = 28(4) ps and tau = 3.7(7) ps, respectively. The lifetime for the 11/2(-) state, which feeds the 9/2(+) and 11/2(+) states, was remeasured with improved accuracy as tau = 216(7) ps. The reduced transition probability, B(E2) = 32(5) W.u., for the 9/2(+) -> 5/2(+) transition agrees with that calculated within the shell model using a Hamiltonian based on the charge-dependent Bonn nucleon-nucleon interaction. In contrast, the much larger transition probability, B(E2) = 209(39) W.u., measured for the 11/2(+) -> 7/2(+) transition has been interpreted, with the aid of configuration-constrained total Routhian surface calculations, as resulting from a slightly gamma-soft rotor with an associated quadrupole deformation of beta(2) approximate to 0.18. Remarkably similar reduced E1 transition probabilities of 5.5(5) x 10(-4) and 4.9(5) x 10(-4) W.u. were deduced for the 11/2(-) -> 9/2(+) and 11/2(-) -> 11/2(+) transitions, respectively, which feed apparently dissimilar but competing structures.
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| 26. |
- Badran, H., et al.
(författare)
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Confirmation of the new isotope Pb-178
- 2016
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Ingår i: PHYSICAL REVIEW C. - 2469-9985. ; 94:5
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Tidskriftsartikel (refereegranskat)abstract
- The extremely neutron-deficient isotope Pb-178 has been produced. The GREAT spectrometer at the focal plane position of the gas-filled separator RITU was used to study the alpha decay of Pb-178 and its alpha-decay chain through alpha-alpha correlations. The alpha decay was measured to have an energy and half-life of E-alpha = 7610(30) keV and t(1/2) = 0.21(-0.08)(+0.21) ms, respectively. The half-life is consistent with recent theoretical calculations using the Coulomb and proximity potential model. The alpha-decay reduced width and hindrance factor for Pb-178 were deduced and correspond to an unhindered Delta l = 0 transition. In addition, the mass excess of Pb-178 and the alpha-decay Q value were calculated from the experimental results and compared to theoretical values.
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| 27. |
- Badran, H., et al.
(författare)
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Decay spectroscopy of Pb-179(82)97 and evidence for a 9/2(-) intruder state in Tl-179(81)98
- 2017
-
Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 96:6
-
Tidskriftsartikel (refereegranskat)abstract
- The very neutron-deficient isobars Pb-179 and Tl-179 have been produced using the fusion-evaporation reactions Pd-104(Kr-78,xpyn), where x <= 1 and y >= 2. The gas-filled separator RITU was employed to transport and separate the recoiling nuclei of interest from the scattered beam and unwanted products. The GREAT spectrometer was used to study the decay properties through alpha-alpha and alpha-gamma correlations, which has allowed the ground state of Pb-179 to be assigned as I-pi = 9/2(-). The decay of Pb-179 was measured to have an alpha-particle energy and half-life of E-alpha = 7348(5) keV and t(1/2) = 2.7(2) ms, respectively. A search for a nu i(13/2) state in Pb-179 was performed, but only a limit of excitation energy and half-life was obtained. In Tl-179 a t(1/2) = 114(-10)(+18) ns isomeric state, likely at an excitation energy of 904.5(9) keV, was identified and is tentatively assigned to be a 9/2(-) proton intruder state.
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| 28. |
- Doncel, Maria, et al.
(författare)
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Lifetime measurement of the first excited 2(+) state in Te-112
- 2015
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 91:6
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Tidskriftsartikel (refereegranskat)abstract
- The lifetime of the 2(+) --> 0(g.s.)(+) transition in the neutron-deficicient nucleus Te-112 has been measured for the first time using the DPUNS plunger and the recoil distance Doppler shift technique. The deduced value for the reduced transition probability is B(E2 :0(g.s.)(+) --> 2(+)) = 0.46 +/- 0.04 e(2)b(2), indicating that there is no unexpected enhancement of the B(E2 :0(g.s.)(+) --> 2(+)) values in Te isotopes below the midshell. The result is compared to and discussed in the framework of large-scale shell-model calculations.
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| 29. |
- Doncel, Maria, et al.
(författare)
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Spin-dependent evolution of collectivity in Te 112
- 2017
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:5
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Tidskriftsartikel (refereegranskat)abstract
- The evolution of collectivity with spin along the yrast line in the neutron-deficient nucleus Te112 has been studied by measuring the reduced transition probability of excited states in the yrast band. In particular, the lifetimes of the 4+ and 6+ excited states have been determined by using the recoil distance Doppler-shift method. The results are discussed using both large-scale shell-model and total Routhian surface calculations.
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| 30. |
- Edqvist, Per-Henrik D., et al.
(författare)
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Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma
- 2015
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 137:3, s. 529-537
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Tidskriftsartikel (refereegranskat)abstract
- Objective For endometrial carcinoma, prognostic stratification methods do not satisfactorily identify patients with adverse outcome. Currently, histology, tumor grade and stage are used to tailoring surgical treatment and to determine the need for adjuvant treatment. Low-risk patients are not considered to require adjuvant therapy or staging lymphadenectomy. For patients with intermediate or high risk, some guidelines recommend tailoring adjuvant treatment according to additional negative prognostic factors. Our objective was to evaluate the biomarker potential of the ASRGL1 protein in endometrial carcinoma. Methods Using The Human Protein Atlas (www.proteinatlas.org), the l-asparaginase (ASRGL1) protein was identified as an endometrial carcinoma biomarker candidate. ASRGL1 expression was immunohistochemically evaluated with an extensively validated antibody on two independent endometrial carcinoma cohorts (n = 229 and n = 286) arranged as tissue microarrays. Staining results were correlated with clinical features. Results Reduced expression of ASRGL1, defined as < 75% positively stained tumor cells, was significantly associated with poor prognosis and reduced disease-specific survival in endometrioid endometrial adenocarcinoma (EEA). In multivariate analysis the hazard ratios for disease-specific survival were 3.55 (95% CI = 1.10-11.43; p = 0.003) and 3.23 (95% CI = 1.53-6.81; p = 0.002) in the two cohorts, respectively. Of the 48 cases with Grade 3 Stage I tumor all disease-related deaths were associated with low ASRGL1 expression. Conclusions Loss of ASRGL1 in EEA is a powerful biomarker for poor prognosis and retained ASRGL1 has a positive impact on survival. ASRGL1 immunohistochemistry has potential to become an additional tool for prognostication in cases where tailoring adjuvant treatment according to additional prognostic factors besides grade and stage is recommended.
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| 31. |
- Huvila, J., et al.
(författare)
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Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma
- 2018
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Ingår i: Gynecologic Oncology. - : Academic Press Inc.. - 0090-8258 .- 1095-6859. ; 149:1, s. 173-180
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Tidskriftsartikel (refereegranskat)abstract
- Objective: In clinical practise, prognostication of endometrial cancer is based on clinicopathological risk factors. The use of immunohistochemistry-based markers as prognostic tools is generally not recommended and a systematic analysis of their utility as a panel is lacking. We evaluated whether an immunohistochemical marker panel could reliably assess endometrioid endometrial cancer (EEC) outcome independent of clinicopathological information. Methods: A cohort of 306 EEC specimens was profiled using tissue microarray (TMA). Cost- and time-efficient immunohistochemical analysis of well-established tissue biomarkers (ER, PR, HER2, Ki-67, MLH1 and p53) and two new biomarkers (L1CAM and ASRGL1) was carried out. Statistical modelling with embedded variable selection was applied on the staining results to identify minimal prognostic panels with maximal prognostic accuracy without compromising generalizability. Results: A panel including p53 and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P < 0.001) of dying of EEC compared to the low-risk group. Conclusions: P53 and ASRGL1 immunoprofiling stratifies EEC patients into three risk groups with significantly different outcomes. This simple and easily applicable panel could provide a useful tool in EEC risk stratification and guiding the allocation of treatment modalities.
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| 32. |
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| 33. |
- Jakobsson, Ulrika, et al.
(författare)
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Spectroscopy of Low-lying States in Neutron-deficient Astatine and Francium Nuclei
- 2015
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Ingår i: NUCLEAR STRUCTURE AND DYNAMICS '15. - : American Institute of Physics (AIP). - 9780735413283
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Konferensbidrag (refereegranskat)abstract
- Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2(+) state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2(+) state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2(+) state and the spherical 9/2(-) ground state in Fr-203 and Fr-205.
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| 34. |
- Jarvilehto, J., et al.
(författare)
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Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy
- 2022
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Ingår i: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo characterize serum biomarkers in mitochondrial CHCHD10-linked spinal muscular atrophy Jokela (SMAJ) type for disease monitoring and for the understanding of pathogenic mechanisms. MethodsWe collected serum samples from a cohort of 49 patients with SMAJ, all carriers of the heterozygous c.197G>T p.G66V variant in CHCHD10. As controls, we used age- and sex-matched serum samples obtained from Helsinki Biobank. Creatine kinase and creatinine were measured by standard methods. Neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) were measured with single molecule array (Simoa), fibroblast growth factor 21 (FGF-21), and growth differentiation factor 15 (GDF-15) with an enzyme-linked immunosorbent assay. For non-targeted plasma metabolite profiling, samples were analyzed with liquid chromatography high-resolution mass spectrometry. Disease severity was evaluated retrospectively by calculating a symptom-based score. ResultsAxon degeneration marker, NfL, was unexpectedly not altered in the serum of patients with SMAJ, whereas astrocytic activation marker, GFAP, was slightly decreased. Creatine kinase was elevated in most patients, particularly men. We identified six metabolites that were significantly altered in serum of patients with SMAJ in comparison to controls: increased creatine and pyruvate, and decreased creatinine, taurine, N-acetyl-carnosine, and succinate. Creatine correlated with disease severity. Altered pyruvate and succinate indicated a metabolic response to mitochondrial dysfunction; however, lactate or mitochondrial myopathy markers FGF-21 or GDF-15 was not changed. ConclusionsBiomarkers of muscle mass and damage are altered in SMAJ serum, indicating a role for skeletal muscle in disease pathogenesis in addition to neurogenic damage. Despite the minimal mitochondrial pathology in skeletal muscle, signs of a metabolic shift can be detected.
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| 35. |
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| 36. |
- Kallionpaa, R. A., et al.
(författare)
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Increased risk for dementia in neurofibromatosis type 1
- 2021
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Ingår i: Genetics in Medicine. - : Elsevier BV. - 1098-3600.
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To determine the risk for dementia in neurofibromatosis type 1 (NF1) using a Finnish nationwide cohort of individuals with NF1, and data from national registries. Methods A Finnish cohort of 1,349 individuals with confirmed NF1 according to the US National Institutes of Health (NIH) diagnostic criteria was compared with a control cohort of 13,870 individuals matched for age, sex, and area of residence. Dementia-related hospital visits were retrieved from the Finnish Care Register for Health Care using International Classification of Diseases, 10th revision (ICD-10) diagnosis codes G30 and F00-F03. Purchases of antidementia drugs were queried with Anatomical Therapeutic Chemical (ATC) classification code N06D from the drug reimbursement register maintained by the Social Insurance Institution of Finland. The follow-up spanned 1998-2014. Results Totals of 16 and 165 individuals with at least two dementia-related diagnoses or drug purchases were identified in the NF1 and control cohorts, respectively. The hazard ratio for dementia in NF1 was 1.67 (95% confidence interval [CI] 1.00-2.80, P = 0.050). In an analysis stratified by the type of dementia, the risk for Alzheimer disease was increased in NF1 compared to controls with a hazard ratio of 2.88 (95% CI 1.47-5.66, P = 0.002). Conclusion Dementia and especially Alzheimer disease are previously unrecognized neurological complications of NF1.
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| 37. |
- Kemilainen, H., et al.
(författare)
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The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer
- 2018
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Ingår i: Oncology. - : S. Karger AG. - 0030-2414 .- 1423-0232. ; 94:4, s. 233-242
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to characterize the expression of hydroxysteroid (17 beta) dehydrogenase type 12 (HSD17B12), an enzyme involved in the synthesis of arachidonic acid (AA), in ovarian cancer, and to study its coexpression with its upstream and downstream enzymes in the AA pathway, namely elongation of very long chain fatty acids protein 5 (ELOVL5) and cyclooxygenase-2 (COX-2), respectively. Materials and Methods: Samples from benign and malignant ovarian neoplastic lesions were immunohistochemically stained with HSD17B12, ELOVL5, and COX-2. The staining intensities were quantified with the QuantCenter program, and the results were confirmed with visual inspection. Statistical significances were calculated with the Student t test, the Mann-Whitney test, linear regression, or ANOVA. Results: The expression of the HSD17B12, ELOVL5, and COX-2 enzymes increased according to the grade of the endometrioid ovarian adenocarcinomas. In contrast, in serous adenocarcinomas, staining with ELOVL5 was constantly weak, whereas the expression of HSD17B12 and COX-2 increased with the grade or FIGO stage of the cancer, respectively. Conclusions: The expression of HSD17B12 increased along with the severity of ovarian cancer, and the expression mimicked COX-2 expression and intensity. This further suggests the involvement of HSD17B12 in AA production, and its coexpression with COX-2 indicates a role for the enzyme in the increased prostaglandin production during ovarian cancer progression. (C) 2018 S. Karger AG, Basel
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| 38. |
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| 39. |
- Lehtonen, J. M., et al.
(författare)
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Diagnostic value of serum biomarkersFGF21andGDF15compared to muscle sample in mitochondrial disease
- 2021
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Ingår i: Journal of Inherited Metabolic Disease. - : Wiley. - 0141-8955 .- 1573-2665. ; 44:2, s. 469-480
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare the value of serum biomarkers, fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15), with histological analysis of muscle in the diagnosis of mitochondrial disease. We collected 194 serum samples from patients with a suspected or known mitochondrial disease. Biomarkers were analyzed blinded using enzyme-labeled immunosorbent assay. Clinical data were collected using a structured questionnaire. Only 39% of patients with genetically verified mitochondrial disease had mitochondrial pathology in their muscle histology. In contrast, biomarkers were elevated in 62% of patients with genetically verified mitochondrial disease. Those with both biomarkers elevated had a muscle manifesting disorder and a defect affecting mitochondrial DNA expression. If at least one of the biomarkers was induced and the patient had a myopathic disease, a mitochondrial DNA expression disease was the cause with 94% probability. Among patients with biomarker analysis and muscle biopsy taken <12 months apart, a mitochondrial disorder would have been identified in 70% with analysis of FGF21 and GDF15 compared to 50% of patients whom could have been identified with muscle biopsy alone. Muscle findings were nondiagnostic in 72% (children) and 45% (adults). Induction of FGF21 and GDF15 suggest a mitochondrial etiology as an underlying cause of a muscle manifesting disease. Normal biomarker values do not, however, rule out a mitochondrial disorder, especially if the disease does not manifest in muscle. We suggest that FGF21 and GDF15 together should be first-line diagnostic investigations in mitochondrial disease complementing muscle biopsy.
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| 40. |
- Loponen, Niina, et al.
(författare)
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Hypertension in NF1: A closer look at the primacy of essential hypertension versus secondary causes
- 2024
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Ingår i: Molecular Genetics and Genomic Medicine. - 2324-9269. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to analyze hypertension in neurofibromatosis type 1 (NF1) in a Finnish population-based cohort in 1996–2014. Methods: A cohort of 1365 individuals with confirmed NF1 was compared with a control cohort of 13,923 individuals matched for age, sex, and area of residence. Diagnoses of hypertension were retrieved from the Finnish Care Register for Health Care. These registered data were separately analyzed for secondary and essential hypertension. Purchases of antihypertensive drugs were queried from the Finnish Register of Reimbursed Drug Purchases. Results: We identified 115 NF1 patients with hospital diagnosis of hypertension. Our findings revealed a hazard ratio (HR) of 1.64 (95% CI 1.34–2.00, p < 0.001) in NF1 versus controls. NF1 patients presented with a significantly increased hazard for both secondary hypertension (n = 9, HR 3.76, 95% CI 1.77–7.95, p < 0.001) and essential hypertension (n = 98, HR 1.73, 95% CI 1.39–2.14, p < 0.001). No difference in the HR of hypertension was observed between men and women, while NF1 patients with essential hypertension were, on average, younger than the controls. The proportions of individuals with antihypertensive medication did not differ between NF1 patients and controls (OR 0.85). Conclusion: NF1 is a risk factor for hypertension. Despite the recognized risk for secondary hypertension, essential hypertension is the predominant type in NF1.
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