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Sökning: WFRF:(Bäckström David)

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1.
  • Bäckström, Torbjörn, et al. (författare)
  • Effects of hormones on seizure expression
  • 2023. - 3
  • Ingår i: Epilepsy. - New York : Wolters Kluwer. - 9781975105525 ; , s. 779-792
  • Bokkapitel (refereegranskat)
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2.
  • af Bjerkén, Sara, et al. (författare)
  • Reliability and validity of visual analysis of [18F]FE-PE2I PET/CT in early Parkinsonian disease
  • 2023
  • Ingår i: Nuclear medicine communications. - : Wolters Kluwer. - 0143-3636 .- 1473-5628. ; 44:5, s. 397-406
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: [18F]FE-PE2I (FE-PE2I) is a new radiotracer for dopamine transporter (DAT) imaging with PET. The aim of this study was to evaluate the visual interpretation of FE-PE2I images for the diagnosis of idiopathic Parkinsonian syndrome (IPS). The inter-rater variability, sensitivity, specificity, and diagnostic accuracy for visual interpretation of striatal FE-PE2I compared to [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) was evaluated.Methods: Thirty patients with newly onset parkinsonism and 32 healthy controls with both an FE-PE2I and FP-CIT were included in the study. Four patients had normal DAT imaging, of which three did not fulfil the IPS criteria at the clinical reassessment after 2 years. Six raters evaluated the DAT images blinded to the clinical diagnosis, interpreting the image as being ‘normal’ or ‘pathological’, and assessed the degree of DAT-reduction in the caudate and putamen. The inter-rater agreement was assessed with intra-class correlation and Cronbach’s α. For calculation of sensitivity and specificity, DAT images were defined as correctly classified if categorized as normal or pathological by ≥4/6 raters.Results: The overall agreement in visual evaluation of the FE-PE2I- and FP-CIT images was high for the IPS patients (α = 0.960 and 0.898, respectively), but lower in healthy controls (FE-PE2I: α = 0.693, FP-CIT: α = 0.657). Visual interpretation gave high sensitivity (both 0.96) but lower specificity (FE-PE2I: 0.86, FP-CIT: 0.63) with an accuracy of 90% for FE-PE2I and 77% for FP-CIT.Conclusion: Visual evaluation of FE-PE2I PET imaging demonstrates high reliability and diagnostic accuracy for IPS.
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3.
  • Ainegren, Mats, 1963-, et al. (författare)
  • A Study of Skin-Close Heat and Moisture with Different Types of Backpacks in Cycling
  • 2020
  • Ingår i: The 13th Conference of the International Sports Engineering Association. - Basel Switzerland : MDPI.
  • Konferensbidrag (refereegranskat)abstract
    • The aim of this project was to evaluate effects of backpacks with different design intended for use during cycling on skin-close temperature and relative humidity, oxygen uptake, heart rate and aerodynamic drag. Seven subjects took part in the study cycling on a mountain bike mounted on a “smart trainer” placed on a force plate in a wind tunnel. Three series of experiments were carried out: without backpack, with conventional backpack and with a backpack having innovative rear panel design. As hypothesized, the results showed that an innovatively designed backpack with the ducts deflecting part of the airflow towards some areas of the user’s back provided lower temperature and relative humidity for the microclimate compared to a conventional backpack without airflow channels. Further, reference tests without any backpack resulted in the lowest temperature and humidity. However, no differences were found between the three tests for oxygen uptake, heart rate and aerodynamic drag.
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4.
  • Bengtsson, Sara K. S., 1978-, et al. (författare)
  • Extra-synaptic GABAA receptor potentiation and neurosteroid-induced learning deficits are inhibited by GR3027, a GABAA modulating steroid antagonist
  • 2023
  • Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 13:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives In Vitro: To study the effects of GR3027 (golexanolone) on neurosteroid-induced GABA-mediated current responses under physiological GABAergic conditions with recombinant human α5β3γ2L and α1β2γ2L GABAA receptors expressed in human embryonic kidney cells, using the response patch clamp technique combined with the Dynaflow™ application system. With α5β3γ2L receptors, 0.01–3 μM GR3027, in a concentration-dependent manner, reduced the current response induced by 200 nM THDOC + 0.3 µM GABA, as well as the THDOC-induced direct gated effect. GR3027 (1 μM) alone had no effect on the GABA-mediated current response or current in the absence of GABA. With α1β2γ2L receptors, GR3027 alone had no effect on the GABA-mediated current response or did not affect the receptor by itself. Meanwhile, 1–3 µM GR3027 reduced the current response induced by 200 nM THDOC + 30 µM GABA and 3 µM GR3027 that induced by 200 nM THDOC when GABA was not present. Objectives In Vivo: GR3027 reduces allopregnanolone (AP)-induced decreased learning and anesthesia in male Wistar rats. Rats treated i.v. with AP (2.2 mg/kg) or vehicle were given GR3027 in ratios of 1:0.5 to 1:5 dissolved in 10% 2-hydroxypropyl-beta-cyclodextrin. A dose ratio of AP:GR3027 of at least 1:2.5 antagonized the AP-induced decreased learning in the Morris Water Mase (MWM) and 1:7.5 antagonized the loss of righting reflex (LoR). GR3027 treatment did not change other functions in the rat compared to the vehicle group. Conclusions: GR3027 functions in vitro as an inhibitor of GABAA receptors holding α5β3γ2L and α1β2γ2L, in vivo, in the rat, as a dose-dependent inhibitor toward AP’s negative effects on LoR and learning in the MWM.
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5.
  • Brydsten, Ulf, et al. (författare)
  • Thermal conductivity of single-crystal NaCl under uniaxial compression
  • 1983
  • Ingår i: Journal of Physics C: Solid State Physics. - : Institute of Physics Publishing (IOPP). - 0022-3719. ; 16:1, s. 143-146
  • Tidskriftsartikel (refereegranskat)abstract
    • The variation of the thermal conductivity of single-crystal NaCl under uniaxial compression is investigated by the dynamic hot-strip method. Over a stress range of 0-1.0 MPa no effect whatsoever is found. The relative change in thermal conductivity under uniaxial compression must be smaller than 1.5*10-9 Pa-1, contrary to the result of an earlier investigation. 
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6.
  • Bäckström, Alexandra, et al. (författare)
  • Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells
  • 2022
  • Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The CRISPR/Cas9 system offers enormous versatility for functional genomics but many applications have proven to be challenging in primary human cells compared to cell lines or mouse cells. Here, to establish a paradigm for multiplexed gene editing in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs), we used co-delivery of lentiviral sgRNA vectors expressing either Enhanced Green Fluorescent Protein (EGFP) or Kusabira Orange (KuO), together with Cas9 mRNA, to simultaneously edit two genetic loci. The fluorescent markers allow for tracking of either single- or double-edited cells, and we could achieve robust double knockout of the cell surface molecules CD45 and CD44 with an efficiency of ~ 70%. As a functional proof of concept, we demonstrate that this system can be used to model gene dependencies for cell survival, by simultaneously targeting the cohesin genes STAG1 and STAG2. Moreover, we show combinatorial effects with potential synergy for HSPC expansion by targeting the Aryl Hydrocarbon Receptor (AHR) in conjunction with members of the CoREST complex. Taken together, our traceable multiplexed CRISPR/Cas9 system enables studies of genetic dependencies and cooperation in primary HSPCs, and has important implications for modelling polygenic diseases, as well as investigation of the underlying mechanisms of gene interactions.
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7.
  • Bäckström, David, et al. (författare)
  • Boundary-Scan Test Control in the ATCA Standard
  • 2005
  • Ingår i: EEE European Board Test Workshop,2005.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The backplane in a multi-board system has a limited wiring capability, which makes additional backplane Boundary-Scan wiring to link the boards highly costly. The problem is to access the Boundary-Scan tested boards with the Boundary- Scan controller at the central board. In this paper we propose an approach suitable for the Advanced Telecom Computing Architecture standard where we make use of the existing I2C-bus and the Intelligent Platform Management Bus (IPMB) protocol for application of operational tests. We have defined a protocol with commands and responses as well as a test data format for storing test data on the boards to support the remote execution of Boundary-Scan tests. For validation of the proposed approach we have developed a demonstrator.
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8.
  • Bäckström, David C, et al. (författare)
  • Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease
  • 2015
  • Ingår i: JAMA Neurology. - : American Medical Association. - 2168-6149 .- 2168-6157. ; 72:10, s. 1175-1182
  • Tidskriftsartikel (refereegranskat)abstract
    • IMPORTANCE: Alterations in cerebrospinal fluid (CSF) have been found in Parkinson disease (PD) and in PD dementia (PDD), but the prognostic importance of such changes is not well known. In vivo biomarkers for disease processes in PD are important for future development of disease-modifying therapies. OBJECTIVE: To assess the diagnostic and prognostic value of a panel of CSF biomarkers in patients with early PD and related disorders. DESIGN, SETTING, AND PARTICIPANTS: Regional population-based, prospective cohort study of idiopathic parkinsonism that included patients diagnosed between January 1, 2004, and April 30, 2009, by amovement disorder team at a university hospital that represented the only neurology clinic in the region. Participants were 128 nondemented patients with new-onset parkinsonism (104 with PD, 11 with multiple system atrophy, and 13 with progressive supranuclear palsy) who were followed up for 5 to 9 years. At baseline, CSF from 30 healthy control participants was obtained for comparison. MAIN OUTCOMES AND MEASURES: Cerebrospinal fluid concentrations of neurofilament light chain protein, Aβ1-42, total tau, phosphorylated tau, α-synuclein, and heart fatty acid-binding protein were quantified by 2 blinded measurements (at baseline and after 1 year). Follow-up included an extensive neuropsychological assessment. As PD outcome variables, mild cognitive impairment and incident PDD were diagnosed based on published criteria. RESULTS: Among the 128 study participants, the 104 patients with early PD had a different CSF pattern compared with the 13 patients with progressive supranuclear palsy (baseline area under the receiver operating characteristic curve, 0.87; P < .0001) and the 30 control participants (baseline area under the receiver operating characteristic curve, 0.69; P = .0021). A CSF biomarker pattern associated with the development of PDD was observed. In PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein at baseline were related to future PDD as analyzed by Cox proportional hazards regression models. Combined, these early biomarkers predicted PDD with high accuracy (hazard ratio, 11.8; 95% CI, 3.3-42.1; P = .0001) after adjusting for possible confounders. CONCLUSIONS AND RELEVANCE: The analyzed CSF biomarkers have potential usefulness as a diagnostic tool in patients with parkinsonism. In PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein were related to future PDD, providing new insights into the etiology of PDD.
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10.
  • Bäckström, David C, M.D. 1978-, et al. (författare)
  • NfL as a biomarker for neurodegeneration and survival in Parkinson disease
  • 2020
  • Ingår i: Neurology. - : Wolters Kluwer. - 0028-3878 .- 1526-632X. ; 95:7, s. e827-e838
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To determine whether neurofilament light chain protein in CSF (cNfL), a sensitive biomarker of neuroaxonal damage, reflects disease severity or can predict survival in Parkinson disease (PD).METHODS: We investigated whether disease severity, phenotype, or survival in patients with new-onset PD correlates with cNfL concentrations around the time of diagnosis in the population-based New Parkinsonism in Umeå (NYPUM) study cohort (n = 99). A second, larger new-onset PD cohort (n = 194) was used for independent validation. Association of brain pathology with the cNfL concentration was examined with striatal dopamine transporter imaging and repeated diffusion tensor imaging at baseline and 1 and 3 years.RESULTS: Higher cNfL in the early phase of PD was associated with greater severity of all cardinal motor symptoms except tremor in both cohorts and with shorter survival and impaired olfaction. cNfL concentrations above the median of 903 ng/L conferred an overall 5.8 times increased hazard of death during follow-up. After adjustment for age and sex, higher cNfL correlated with striatal dopamine transporter uptake deficits and lower fractional anisotropy in diffusion tensor imaging of several axonal tracts.CONCLUSIONS: cNfL shows usefulness as a biomarker of disease severity and to predict survival in PD. The present results indicate that the cNfL concentration reflects the intensity of the neurodegenerative process, which could be important in future clinical trials.CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in patients with PD, cNfL concentrations are associated with more severe disease and shorter survival.
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11.
  • Bäckström, David C, M.D. 1978-, et al. (författare)
  • Prediction and early biomarkers of cognitive decline in Parkinson disease and atypical parkinsonism: a population-based study
  • 2022
  • Ingår i: Brain Communications. - : Oxford University Press (OUP). - 2632-1297. ; 4:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Backstrom et al. report that, in a population-based cohort of patients with new-onset Parkinson disease, approximately half develop dementia within 10 years. Measurement of CSF biomarkers together with baseline cognitive function, olfaction and motor disease severity has high accuracy for predicting who will develop dementia. The progression of cognitive decline is heterogeneous in the three most common idiopathic parkinsonian diseases: Parkinson disease, multiple system atrophy and progressive supranuclear palsy. The causes for this heterogeneity are not fully understood, and there are no validated biomarkers that can accurately identify patients who will develop dementia and when. In this population-based, prospective study, comprehensive neuropsychological testing was performed repeatedly in new-onset, idiopathic parkinsonism. Dementia was diagnosed until 10 years and participants (N = 210) were deeply phenotyped by multimodal clinical, biochemical, genetic and brain imaging measures. At baseline, before the start of dopaminergic treatment, mild cognitive impairment was prevalent in 43.4% of the patients with Parkinson disease, 23.1% of the patients with multiple system atrophy and 77.8% of the patients with progressive supranuclear palsy. Longitudinally, all three diseases had a higher incidence of cognitive decline compared with healthy controls, but the types and severity of cognitive dysfunctions differed. In Parkinson disease, psychomotor speed and attention showed signs of improvement after dopaminergic treatment, while no such improvement was seen in other diseases. The 10-year cumulative probability of dementia was 54% in Parkinson disease and 71% in progressive supranuclear palsy, while there were no cases of dementia in multiple system atrophy. An easy-to-use, multivariable model that predicts the risk of dementia in Parkinson disease within 10 years with high accuracy (area under the curve: 0.86, P < 0.001) was developed. The optimized model adds CSF biomarkers to four easily measurable clinical features at baseline (mild cognitive impairment, olfactory function, motor disease severity and age). The model demonstrates a highly variable but predictable risk of dementia in Parkinson disease, e.g. a 9% risk within 10 years in a patient with normal cognition and CSF amyloid-beta(42) in the highest tertile, compared with an 85% risk in a patient with mild cognitive impairment and CSF amyloid-beta(42) in the lowest tertile. Only small or no associations with cognitive decline were found for factors that could be easily modifiable (such as thyroid dysfunction). Risk factors for cognitive decline in multiple system atrophy and progressive supranuclear palsy included signs of systemic inflammation and eye movement abnormalities. The predictive model has high accuracy in Parkinson disease and might be used for the selection of patients into clinical trials or as an aid to improve the prevention of dementia.
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12.
  • Bäckström, David C, M.D. 1978- (författare)
  • The biology of cognitive decline and reduced survival in Parkinson disease : prognostic factors in a population-based cohort
  • 2019
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Parkinson disease (PD) is a progressive neurodegenerative disease that affects about 1% of the population over 60 years. The cardinal symptoms are motor disabilities but cognitive decline is also common. About 50% of all persons with PD develop dementia within 10 years after disease onset. Dementia in PD account for high social costs and has large, negative effects on quality of life. Aims. The aim of the study was to investigate clinical, neurobiological and genetic factors of importance for progression and for the prognosis in PD and parkinsonism. First, we aimed to describe mortality and risk factors for death, including possible associations with cognitive dysfunction, in patients with idiopathic parkinsonism. Second, we aimed to study if biomarkers in the cerebrospinal fluid (CSF) are useful for the diagnosis of different forms of idiopathic parkinsonism and prediction of cognitive decline in PD. Methods. A population-based cohort consisting of patients with new-onset, idiopathic parkinsonism was studied prospectively. After screening in a catchment area of ~142 000 inhabitants in Sweden, 182 patients with parkinsonism were included. The patients were investigated comprehensively, including neuropsychological testing, multimodal neuroimaging and genetic and biosample analyses. During follow up, 143 patients were diagnosed with PD, 13 with multiple system atrophy (MSA), and 18 with progressive supranuclear palsy (PSP). A total of 109 patients died. Results. Patients with MSA and PSP had the shortest life expectancy. PD patients who presented with normal cognitive function had a largely normal life expectancy. In contrast, the mortality was increased in PD patients with cognitive impairment, freezing of gait, hyposmia, and mildly elevated leukocytes in the CSF. Of importance for the prognosis, patients with PD with an early CSF pattern of high Neurofilament light protein, low β-amyloid, and high heart fatty acid binding protein had an 11.8 times increased risk of developing PD dementia (95% CI 3.3-42.1, p <0.001), compared with PD patients with a more ”normal” CSF pattern. Variation in genes associated with dopamine function was also associated with some effects on cognitive functions in PD. Conclusions. PD subtypes, for instance the subtype characterized by cognitive decline, have distinguishing clinical, neurochemical and neurobiological traits, which are of importance for the prognosis and the survival. An early CSF analysis is useful for predicting cognitive decline. The finding of a low-grade immune reaction in the CSF of patients with PD may have clinical implications. In clinical practice, CSF biomarkers could be useful for improving diagnosis and prognostication.
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13.
  • Bäckström, David, et al. (författare)
  • Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study
  • 2018
  • Ingår i: Neurology. - : Wolters Kluwer. - 1526-632X .- 0028-3878. ; 91:22
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To examine mortality and associated risk factors, including possible effects of mild cognitive impairment, imaging, and CSF abnormalities, in a community-based population with incident parkinsonism and Parkinson disease. METHODS: One hundred eighty-two patients with new-onset, idiopathic parkinsonism were diagnosed from January 2004 through April 2009, in a catchment area of 142,000 inhabitants in Sweden. Patients were comprehensively investigated according to a multimodal research protocol and followed prospectively for up to 13.5 years. A total of 109 patients died. Mortality rates in the general Swedish population were used to calculate standardized mortality ratio and expected survival, and Cox proportional hazard models were used to investigate independent predictors of mortality. RESULTS: The standardized mortality ratio for all patients was 1.84 (95% confidence interval 1.50-2.22, p < 0.001). Patients with atypical parkinsonism (multiple system atrophy or progressive supranuclear palsy) had the highest mortality. In early Parkinson disease, a mild cognitive impairment diagnosis, freezing of gait, hyposmia, reduced dopamine transporter activity in the caudate, and elevated leukocytes in the CSF were significantly associated with shorter survival. CONCLUSION: Although patients presenting with idiopathic parkinsonism have reduced survival, the survival is highly dependent on the type and characteristics of the parkinsonian disorder. Patients with Parkinson disease presenting with normal cognitive function seem to have a largely normal life expectancy. The finding of a subtle CSF leukocytosis in patients with Parkinson disease with short survival may have clinical implications. Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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14.
  • Bäckström, David, et al. (författare)
  • PITX3 genotype and risk of dementia in Parkinson's disease : A population-based study
  • 2017
  • Ingår i: Journal of the Neurological Sciences. - : ELSEVIER SCIENCE BV. - 0022-510X .- 1878-5883. ; 381, s. 278-284
  • Tidskriftsartikel (refereegranskat)abstract
    • Dementia is a devastating manifestation of Parkinson's disease (PD). This study investigates whether a common polymorphism in the PITX3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in PD and whether it affects dopamine transporter (DAT) uptake. We PITX3 genotyped 133 patients with new-onset, idiopathic PD, participating in a population-based study in Sweden. Patients were followed prospectively during 6-11 years with extensive investigations, including neuropsychology and DAT-imaging with I-123 FP-CIT. The primary outcome was the incidence of PD dementia (PDD), diagnosed according to published criteria, studied by the Kaplan-Meier method and Cox proportional hazards. Performance in individual cognitive domains, the incidence of visual hallucinations, disease progression and striatal DAT uptake on imaging was also investigated. PD patients carrying the PITX3 C allele had an increased risk of developing PDD (hazard ratio: 2.87, 95% CI: 1.42-5.81, p = 0.003), compared to the PD patients homozygous for the T-allele. Furthermore, the PITX3 C allele carriers with PD had a poorer cognitive performance in the visuospatial domain (p < 0.001) and a higher incidence of visual hallucinations. A trend towards a lower striatal DAT uptake in the PITX3 C allele carriers was suggested, but could not be confirmed. Our results show that a common polymorphism in the PITX3 gene affects the risk of developing PDD and visuospatial dysfunction in idiopathic PD. If validated, these findings can provide new insights into the neurobiology and genetics of non-motor symptoms in PD.
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15.
  • Bäckström, David, et al. (författare)
  • Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease
  • 2018
  • Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 137:1, s. 91-98
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesCognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val(158)Met genotype and DRD2 (CT)-T-957 genotype) affect the development of cognitive deficits in PD. Materials and methodsOne hundred and 34 patients with idiopathic PD, participating in a regional, population-based study of incident parkinsonism, underwent genotyping. After extensive baseline investigations (including imaging and biomarker analyses), the patients were followed prospectively during 6-10 years with neuropsychological evaluations, covering six cognitive domains. Cognitive decline (defined as the incidence of either Parkinson's disease mild cognitive impairment [PD-MCI] or dementia [PDD], diagnosed according to published criteria and blinded to genotype) was studied as the primary outcome. ResultsBoth genotypes affected cognition, as shown by Cox proportional hazards models. While the COMT(158)Val/Val genotype conferred an increased risk of mild cognitive impairment in patients with normal cognition at baseline (hazard ratio: 2.13, P=.023), the DRD2(957)T/T genotype conferred an overall increased risk of PD dementia (hazard ratio: 3.22, P<.001). The poorer cognitive performance in DRD2(957)T/T carriers with PD occurred mainly in episodic memory and attention. ConclusionsThe results favor the hypothesis that dopamine deficiency in PD not only relate to mild cognitive deficits in frontostriatal functions, but also to a decline in memory and attention. This could indicate that dopamine deficiency impairs a wide network of brain areas.
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16.
  • Bäckström, David, et al. (författare)
  • Remote Boundary-Scan System Test Control for the ATCA Standard
  • 2005
  • Ingår i: International Test Conference ITC05,2005. - Austin, Texas, USA : IEEE Computer Society Press. ; , s. 32.2-
  • Konferensbidrag (refereegranskat)abstract
    • The backplane in a multi-board system has a limited wiring capability, which makes additional backplane Boundary-Scan wiring to link the boards highly costly. The problem is to access the Boundary-Scan tested boards with the Boundary- Scan controller at the central board. In this paper we propose an approach suitable for the Advanced Telecom Computing Architecture standard where we make use of the existing I2C-bus and the Intelligent Platform Management Bus (IPMB) protocol for application of operational tests. We have defined a protocol with commands and responses as well as a test data format for storing test data on the boards to support the remote execution of Boundary-Scan tests. For validation of the proposed approach we have developed a demonstrator.
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17.
  • Bäckström, Mikael, et al. (författare)
  • A New Wind Tunnel Facility Dedicated to Sports Technology Research and Development
  • 2016
  • Ingår i: Procedia Engineering. - : Elsevier. ; , s. 62-67
  • Konferensbidrag (refereegranskat)abstract
    • It is desirable to test sportswear and sports equipment at exactly the same conditions experienced during use. Although outdoor tests are in many cases the most adequate, they are at the same time quite complex, demand special measurement technology and wearable equipment. Results of such tests are often hard to interpret due to large variations because of rapidly varying ambient conditions and individual specifics of human objects, among other factors, which are hard or impossible to control. One common alternative is provided through indoor tests made in a stable, controlled environment. Controlling such parameters as temperature, wind speed and direction, air humidity with indoor facilities intended to replicate ambient conditions, and designed to house large objects, is a complex undertaking. Furthermore, replicating seasonal conditions complicates matters even more. A significant amount of research and development related to the operation of sports and other related equipment at high speeds and windy conditions has been carried out in wind tunnels with different degrees of climatic realism. However, the majority of such facilities are designed and constructed for the automotive industry, the aerospace industry and for marine research. A new wind tunnel facility, opened in March 2015 at the Sports Tech Research Centre at Mid Sweden University, is currently among the very few facilities in the world designed under the direct control of sports technology specialists and dedicated primarily to research and development within sports, outdoor clothing and footwear as well as equipment development and testing. The main goal when constructing this dedicated facility has been to successfully replicate ambient conditions for training and equipment testing in environments with controlled wind speed, temperature (+4 to +35°C) and precipitation (from fine mist to heavy downfall). The wind tunnel facility houses the largest moving belt in Sweden (5 m long and 2.7 m wide) which can be adjusted for leveled, uphill and downhill motion. The moving belt is placed in a 10 m2 test section in which the wind speed can be adjusted to match belt speed or independently up to 55 km/h (without narrowing the test section). A fog and rain system, mounted in the test section, can generate rainy conditions varying from fine mist to heavy monsoon. It is also possible to open the facility in order to allow experiments to be performed in wide range of outdoor, ambient conditions. This paper presents the basic parameters of the new wind tunnel facility. As this facility is open for wider international cooperation, we also report the general directions of current research and the future work planned to be carried out at this facility.
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19.
  • Bäckström, Torbjörn, 1948-, et al. (författare)
  • Pathogenesis in menstrual cycle-linked CNS disorders.
  • 2003
  • Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 1007, s. 42-53
  • Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
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20.
  • Carlsson, Peter, et al. (författare)
  • Cross-Country Ski
  • 2015
  • Ingår i: The Engineering Approach to Winter Sports. - New York, NY : Springer. - 9781493930197 ; , s. 107-152
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Cross-country skiing, biathlon and ski orienteering are competitive sports with practitioners who are mostly from countries in the northern hemisphere. The competition season is during the time when the ground is covered with snow, which roughly extends from mid-November to late March. During the rest time of the year, which is a long preparatory period of training for the skiers before the competition season, the skiers use roller skis for dryland training with the aim of imitating skiing on snow. Furthermore, over the last few decades, fairly specific indoor testing methods for cross-country skiers have become possible due to the development of treadmills that allow roller skiing using classical and freestyle techniques.
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21.
  • Cedergren Weber, Gustav, et al. (författare)
  • The Impact of COVID-19 on Parkinson's Disease : A Case-Controlled Registry and Questionnaire Study on Clinical Markers and Patients' Perceptions
  • 2023
  • Ingår i: Acta Neurologica Scandinavica. - : John Wiley & Sons. - 0001-6314 .- 1600-0404. ; 2023
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Parkinson's disease (PD) is a neurodegenerative disease with motor and nonmotor symptoms. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Objectives: To explore how COVID-19 affects motor, nonmotor, and general health aspects of PD and to map how PD patients perceive their change in symptoms since falling ill with COVID-19.Method: The study was descriptive, case-controlled, and based on both registry and questionnaire data. At baseline, the controls were matched on age, sex, and disease severity. Information on the severity of the disease, nonmotor symptoms, motor symptoms, and general health was retrieved from the Swedish Registry for PD. Registry data from a COVID-19 group (n=45) and a control group (n=73), as well as questionnaires from a COVID-19 group (n=24) and a control group (n=42), were compared.Results: We did not find that SARS-CoV-2 infection affects any major aspect of nonmotor symptoms, motor symptoms, general health, and perception of change in PD patients' post-COVID-19. Compared to controls, the COVID-19 group reported a more positive subjective experience of pain and quality of life and a perception of change post-COVID-19 regarding general motor function, sleep quality, and mood (all p<0.05).Conclusion: Although SARS-CoV-2 infection does not seem to affect PD symptoms in any major respect, the subjective experience of several aspects of life in PD patients might be slightly improved post-COVID-19 compared to a control group. The findings warrant further investigations due to the small sample size and possible survivorship bias.
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22.
  • Das, Roshni, et al. (författare)
  • Medroxyprogesterone acetate positively modulates specific GABAA-receptor subtypes - affecting memory and cognition
  • 2022
  • Ingår i: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 141
  • Tidskriftsartikel (refereegranskat)abstract
    • Medroxyprogesterone acetate (MPA) is a progestin widely used in humans as hormone replacement therapy and at other indications. Many progestin metabolites, as the progesterone metabolite allopregnanolone, have GABAA-receptor modulatory effects and are known to affect memory, learning, appetite, and mood. In women, 4 years chronic treatment with MPA doubles the frequency of dementia and in rats, MPA causes cognitive impairment related to the GABAergic system. Activation of the membrane bound GABAA receptor results in a chloride ion flux that can be studied by whole-cell patch-clamp electrophysiological recordings. The purpose of this study was to clarify the modulatory effects of MPA and specific MPA metabolites, with structures like known GABAA-receptor modulators, on different GABAA-receptor subtypes. An additional aim was to verify the results as steroid effects on GABA response in single cells taken from rat hypothalamus. HEK-293 cell-lines permanently expressing the recombinant human GABAA-receptor subtype α1β2γ2L or α5β3γ2L or α2β3γ2S were created. The MPA metabolites 3α5α-MPA,3β5α-MPA and 3β5β-MPA were synthesised and purified for electrophysiological patch-clamp measurements with a Dynaflow system. The effects of MPA and tetrahydrodeoxycorticosterone were also studied. None of the studied MPA metabolites affected the responses mediated by α1β2γ2L or α5β3γ2L GABAA receptors. Contrary, MPA clearly acted both as a positive modulator and as a direct activator of the α5β3γ2L and α2β3γ2S GABAA receptors. However, in concentrations up to 10 μM, MPA was inactive at the α1β2γ2L GABAA receptor. In the patch-clamp recordings from dissociated cells of the preoptic area in rats, MPA increased the amplitude of responses to GABA. In addition, MPA alone without added GABA, evoked a current response. In conclusion, MPA acts as a positive modulator of specific GABAA receptor subtypes expressed in HEK cells and at native GABA receptors in single cells from the hypothalamic preoptic area.
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23.
  • Domellöf, Magdalena Eriksson, et al. (författare)
  • Evaluating a frontostriatal working-memory updating-training paradigm in Parkinson's disease : the iPARK trial, a double-blinded randomized controlled trial
  • 2020
  • Ingår i: BMC Neurology. - : BMC. - 1471-2377. ; 20:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Cognitive decline and dementia are common in Parkinson's disease (PD). Cognitive deficits have been linked to the depletion of dopamine in the nigrostriatal pathway, but pharmacological treatments for PD have little evidence of improving or delaying cognitive decline. Therefore, exploring non-pharmacological treatment options is important. There have been some promising results of cognitive training interventions in PD, especially for improvements in working memory and executive functions. Yet, existing studies are often underpowered, lacking appropriate control condition, long term follow-up, a thorough description of the intervention and characteristics of the participants. Working memory updating training has previously shown to increase striatal activation in healthy young and old participants as well as dopaminergic neurotransmission in healthy young participants. In the light of dopamine dysfunction in PD, with negative effects on both motor and cognitive functions it is of interest to study if an impaired striatal system can be responsive to a non-invasive, non-pharmacological intervention. Methods and design: The iPARK trial is a double-blinded, randomized controlled trial with a parallel-group design that aims to recruit 80 patients with PD (during the period 02/2017-02/2023). Included patients need to have PD, Hoehn and Yahr staging I-III, be between 45 to 75 years of age and not have a diagnosis of dementia. All patients will undergo 30 sessions (6-8 weeks) of web-based cognitive training performed from home. The target intervention is a process-based training program targeting working memory updating. The placebo program is a low dose short-term memory program. A battery of neuropsychological tests and questionnaires will be performed before training, directly after training, and 16 weeks after training. Discussion: We expect that the iPARK trial will provide novel and clinically useful information on whether updating training is an effective cognitive training paradigm in PD. Further, it will hopefully contribute to a better understanding of cognitive function in PD and provide answers regarding cognitive plasticity as well as determining critical factors for a responsive striatal system.
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24.
  • Domino, Steven E, et al. (författare)
  • Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis.
  • 2009
  • Ingår i: Glycoconjugate journal. - : Springer Science and Business Media LLC. - 1573-4986 .- 0282-0080. ; 26:9, s. 1125-34
  • Tidskriftsartikel (refereegranskat)abstract
    • Cervical mucins are glycosylated proteins that form a protective cervical mucus. To understand the role of mucin glycans in Candida albicans infection, oligosaccharides from mouse cervical mucins were analyzed by liquid chromatography-mass spectrometry. Cervical mucins carry multiple alpha(1-2)fucosylated glycans, but alpha(1,2)fucosyltransferase Fut2-null mice are devoid of these epitopes. Epithelial cells in vaginal lavages from Fut2-null mice lacked Ulex europaeus agglutinin-1 (UEA-I) staining for alpha(1-2)fucosylated glycans. Hysterectomy to remove cervical mucus eliminated UEA-I and acid mucin staining in vaginal epithelial cells from wild type mice indicating the cervix as the source of UEA-I positive epithelial cells. To assess binding of alpha(1-2) fucosylated glycans on C. albicans infection, an in vitro adhesion assay was performed with vaginal epithelial cells from wild type and Fut2-null mice. Vaginal epithelial cells from Fut2-null mice were found to bind increased numbers of C. albicans compared to vaginal epithelial cells obtained from wild type mice. Hysterectomy lessened the difference between Fut2-null and wild type mice in binding of C. ablicans in vitro and susceptibility to experimental C. albicans vaginitis in vivo. We generated a recombinant fucosylated MUC1 glycanpolymer to test whether the relative protection of wild type mice compared to Fut2-null mice could be mimicked with exogenous mucin. While a small portion of the recombinant MUC1 epitopes displayed alpha(1-2)fucosylated glycans, the predominant epitopes were sialylated due to endogenous sialyltransferases in the cultured cells. Intravaginal instillation of recombinant MUC1 glycanpolymer partially reduced experimental yeast vaginitis suggesting that a large glycanpolymer, with different glycan epitopes, may affect fungal burden.
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25.
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26.
  • Efverström, Anna, et al. (författare)
  • Anti-doping and legitimacy : an international survey of elite athletes’ perceptions
  • 2016
  • Ingår i: International Journal of Sport Policy. - : Informa UK Limited. - 1940-6940 .- 1940-6959. ; , s. 491-514
  • Tidskriftsartikel (refereegranskat)abstract
    • Anti-doping work is a comprehensive enterprise that entails control and governance of elite athletes’ everyday lives. However, in policy-making regarding doping and anti-doping in elite sports, the athletes’ perspective has not been considered adequately. Focusing on elite athletes’ perceptions of anti-doping as both principle and praxis, the study aimed to analyse how these perceptions can be understood from a legitimacy perspective. A survey study involving 261 elite athletes from 51 different countries and four international sports federations was conducted. The results showed that the athletes did not question the legitimacy of the rules, but had concerns about the legitimacy of the way the rules and principles are enforced in practice, specifically with regard to matters of privacy, lack of efficiency and equal conditions as well as athletes’ involvement in the anti-doping work. The article describes how athletes’ perceptions of the legitimacy of anti-doping work constitute the basis for their willingness to follow regulations as well as a precondition for the work’s functionality and stability. In light of this finding, the article calls for the empowerment of athletes in anti-doping work.
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27.
  • Efverström, Anna, et al. (författare)
  • Contexts and conditions for a level playing field : Elite athletes’ perspectives on anti-doping in practice
  • 2016
  • Ingår i: Performance Enhancement & Health. - : Elsevier BV. - 2211-2669. ; 5:2, s. 77-85
  • Tidskriftsartikel (refereegranskat)abstract
    • The implementation of global anti-doping regulations was intended to provide a level playing field for all athletes entering sports competitions. However, studies have shown that the worldwide harmonization of rules has not been entirely efficacious. For instance, great variation has been found in how anti-doping organizations implement anti-doping regulations, and it has also been shown that athletes distrust the equivalence of the worldwide rules as regards their effects. The purpose of the present article is to examine how elite athletes from different contexts experience anti-doping procedures and to analyse the legitimacy of anti-doping practice. In order to capture a variety of voices and perspectives, 13 elite athletes from five different continents and three international sports federations were interviewed. The analysis shows that when global anti-doping policy is implemented in different contexts and under different conditions, inequities and structural injustices emerge concerning infrastructure, knowledge and support at the individual athlete level. These consequences may have implications for the legitimacy of anti-doping work, because the existence of procedural justice may be called into questioned. We therefore suggest that anti-doping policy-making should be based on taking into account these different conditions and being aware of the perspectives that underpin regulations intended to be applied global.
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28.
  • Gonzalez, Maria Camila, et al. (författare)
  • Cognitive and motor decline in dementia with lewy bodies and Parkinson's disease dementia
  • 2023
  • Ingår i: Movement Disorders Clinical Practice. - : John Wiley & Sons. - 2330-1619. ; 10:6, s. 980-986
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD).Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts.Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157).Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]).Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.
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29.
  • Haage, David, et al. (författare)
  • Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus.
  • 2005
  • Ingår i: Brain Research. - : Elsevier BV. - 0006-8993. ; 1033:1, s. 58-67
  • Tidskriftsartikel (refereegranskat)abstract
    • The two neurosteroids 3alpha-hydroxy-5alpha-pregnane-20-one (allopregnanolone; AlloP) and pregnenolone sulfate (PregS) affect neuronal GABA(A) receptors differently. While AlloP mainly potentiates the currents through GABA(A) receptors, PregS reduces such currents. The present study aimed at clarifying the interaction of AlloP and PregS at GABA(A) receptors in neurons from the medial preoptic nucleus of male rat. AlloP has previously been shown to dramatically prolong GABA-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in these neurons. Here, by recording sIPSCs under voltage-clamp conditions with the perforated-patch technique, it was shown that PregS by itself did not significantly affect the amplitude or time course of such currents. However, PregS, in a concentration-dependent manner, reduced the AlloP-evoked prolongation of sIPSC decay when the two neurosteroids were applied together. In contrast to sIPSC amplitude and time course, sIPSC frequency was significantly reduced by 10 microM PregS alone. Further, although 1.0 microM AlloP alone induced a clear increase in sIPSC frequency, the frequency was not significantly different from control when 1.0 microM AlloP was applied in combination with 10 microM PregS. In addition to the effects on sIPSC parameters, PregS reduced the baseline current evoked by 1.0 microM AlloP in the absence of GABA application or synaptic activity. PregS by itself did not significantly affect the baseline current. The main effects of AlloP and PregS on the sIPSC time course were mimicked by a simplified model with AlloP assumed to reduce the rate of GABA unbinding from the receptor and PregS assumed to increase the rate of desensitization.
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30.
  • Hallgren, Jenny, 1978-, et al. (författare)
  • ‘Who will do it if I don’t?’ : Nurse anaesthetists’ experiences of working in the intensive care unit during the COVID-19 pandemic
  • 2022
  • Ingår i: Australian Critical Care. - : Elsevier. - 1036-7314 .- 1878-1721. ; 35:1, s. 52-58
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: During the COVID-19 pandemic, the workload on the intensive care unit (ICU) increased nationally in Sweden as well as globally. Certified registered nurse anaesthetics (CRNAs) in Sweden were transferred at short notice to work with seriously ill patients with COVID-19 in the ICU, which is not part of the CRNAs’ specialist area. However, limited research has shed light on healthcare professionals’ experiences of the pandemic.Objectives: This study illuminates CRNAs’ experiences of working in the ICU during the COVID-19 pandemic.Methods: This study used a qualitative method with an inductive approach to interview nurse anaesthetists’ who worked in the ICU during the COVID-19 pandemic.Findings: The participants experienced ambivalent feelings towards their work in the ICU. They also lacked information, which created feelings of uncertainty and resulted in expectations that did not correspond to the reality. They described that due to an inadequate introduction, they could only provide “sufficient” care, which in many cases caused ethical stress. Not being able to get to know their new colleagues well enough to create effective cooperation created frustration. Even though the participants experienced the work in the ICU as demanding and challenging, overall, they enjoyed their time in the ICU and were treated well by their colleagues.Conclusions: While CRNAs cannot replace intensive care nurses (ICNs), they are a useful resource in the ICU in the care of patients with COVID-19. Healthcare workers who are allocated from their ordinary units to the ICU need adequate information and support from their work managers to be able to provide the best possible care and to stay healthy themselves.
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31.
  • Holmberg, Ellinor, et al. (författare)
  • Allopregnanolone induces a diurnally dependent hyperphagic effect and alters feeding latency and duration in male Wistar rats
  • 2013
  • Ingår i: Acta Physiologica. - : John Wiley & Sons. - 1748-1708 .- 1748-1716. ; 208:4, s. 400-409
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: Gamma-aminobutyric acid (GABA)-ergic transmission from the hypothalamus is essential for normal feeding regulation, and hyperphagia can be induced by local application of GABA(A)-receptor agonists to different feeding-associated brain areas. The food intake in rats varies diurnally and that may influence the effect of GABA(A)-receptor active compounds. The progesterone metabolite allopregnanolone is a highly potent endogenous positive modulator of the GABA(A) receptor. Therefore, it is easy to envisage that allopregnanolone would have a hyperphagic effect, but earlier reports in rat have given ambiguous results. However, a contributing factor for the discrepancy may be the time point of the diurnal cycle in which the experiments were performed. The aim of this study was to investigate the effect of allopregnanolone on intake of standard chow in male Wistar rats at different time points of the day.Methods: Chow intake was measured after acute administration of allopregnanolone, and feeding behaviour was analysed to detect meal patterns.Results: We found that allopregnanolone increased chow intake by up to four times in the dark part of the 24-h cycle. The rats ate significantly more, and the effect of allopregnanolone was more prominent in the active (dark) compared with the inactive (light) period. Allopregnanolone also reduced feeding latency and prolonged the meal duration compared with vehicle.Conclusion: Allopregnanolone seems to act at several levels of feeding regulation, that is, to initiate feeding and to prolong the duration of a meal, thereby increasing the meal size, especially in the dark period of the 24-h cycle.
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32.
  • Holmberg, Ellinor, 1975-, et al. (författare)
  • Allopregnanolone preferentially induces energy-rich food intake in male Wistar rats
  • 2014
  • Ingår i: Physiological Reports. - : Wiley Periodicals Inc.. - 2051-817X. ; 2:12, s. e12190-
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is an increasing problem and identification of the driving forces for overeating of energy-rich food is important. Previous studies show that the stress and sex steroid allopregnanolone has a hyperphagic effect on both bland food and palatable food. If allopregnanolone induces a preference for more palatable or for more energy-rich food is not known. The aim of this study  was to elucidate the influence of allopregnanolone on food preference. Male Wistar rats were subjected to two different food preference tests: a choice between standard chow and cookies (which have a higher energy content and also are more palatable than chow), and a choice between a low caloric sucrose solution and standard chow (which has a higher energy content and is less palatable than sucrose). Food intake was measured for 1 h after acute subcutaneous injections of allopregnanolone. In the choice between cookies and chow allopregnanolone significantly increased only the intake of cookies.When the standard chow was the item present with the highest caloric load, the chow intake was increased and allopregnanolone had no effect on intake of the 10% sucrose solution. The increased energy intakes induced by the high allopregnanolone dose compared to vehicle were very similar in the two tests,120% increase for cookies and 150% increase for chow. It appears that in allopregnanolone-induced hyperphagia, rats choose the food with the highest energy content regardless of its palatability.
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33.
  • Holmberg, Ellinor, 1975-, et al. (författare)
  • Repeated allopregnanolone exposure induces weight gain in schedule fed rats on high fat diet
  • 2015
  • Ingår i: Physiology and Behavior. - : Elsevier. - 0031-9384 .- 1873-507X. ; 140, s. 1-7
  • Tidskriftsartikel (refereegranskat)abstract
    • Ingestion of energy rich high fat diets is one of the determining factors associated with the obesity epidemic. Therefore, much can be learned from studies of obesity-related substances given to animals fed a high fat diet.The progesterone metabolite allopregnanolone is a potent positive modulator of the gamma-aminobutyric acid(GABA)A-receptor, and both allopregnanolone and GABA have been implicated in evoking hyperphagia. In this study, food intake and body weight gain were investigated during repeated allopregnanolone exposure. Male Wistar rats were studied when fed chow ad libitum, with chow access for 4h per day or with 45% high fat pellets for 4 h per day. Rats on the high fat diet were separated into obesity prone and obesity resistant individuals.Subcutaneous injections of allopregnanolone were given once daily overfive consecutive days. Repeated exposure to allopregnanolone lead to increased weight gain, significantly so in schedule fed rats on a high fat diet. The increased weight gain was correlated to an increased energy intake. Both obesity resistant and obesityprone rats responded to allopregnanolone with increased weight gain. Obesity resistant rats treated with allopregnanolone increased their energy intake and ate as much as vehicle treated obesity prone rats. Their weight gain was also increased to the level of obesity prone rats injected with just the vehicle carrier oil. Thus, it appears that allopregnanolone may be one of the endogenous factors involved in weight gain, especiallywhen the diet is rich in fat.
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34.
  • Jakobson Mo, Susanna, et al. (författare)
  • Dopamine transporter imaging with [18F]FE-PE2I PET and [123I]FP-CIT SPECT – a clinical comparison
  • 2018
  • Ingår i: EJNMMI Research. - : Springer. - 2191-219X. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Dopamine transporter (DAT) imaging may be of diagnostic value in patients with clinically suspected parkinsonian disease. The purpose of this study was to compare the diagnostic performance of DAT imaging with positron emission computed tomography (PET), using the recently developed, highly DAT-selective radiopharmaceutical [18F]FE-PE2I (FE-PE2I), to the commercially available and frequently used method with [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) in early-stage idiopathic parkinsonian syndrome (PS).Methods: Twenty-two patients with a clinical de novo diagnosis of PS and 28 healthy controls (HC) participating in an on-going clinical trial of FE-PE2I were analyzed in this study. Within the trial protocol, participants are clinically reassessed 2 years after inclusion. A commercially available software was used for automatic calculation of FP-CIT-specific uptake ratio (SUR). MRI-based volumes of interest combined with threshold PET segmentation were used for FE-PE2I binding potential relative to non-displaceable binding (BPND) quantification and specific uptake value ratios (SUVR).Results: PET with FE-PE2I revealed significant differences between patients with a clinical de novo diagnosis of PS and healthy controls in striatal DAT availability (p < 0.001), with excellent accuracy of predicting dopaminergic deficit in early-stage PS. The effect sizes were calculated for FE-PE2I BPND (Glass’s Δ = 2.95), FE-PE2I SUVR (Glass’s Δ = 2.57), and FP-CIT SUR (Glass’s Δ = 2.29). The intraclass correlation (ICC) between FE-PE2I BPND FP-CIT SUR was high in the caudate (ICC = 0.923), putamen (ICC = 0.922), and striatum (ICC = 0.946), p < 0.001. Five of the 22 patients displayed preserved striatal DAT availability in the striatum with both methods. At follow-up, a non-PS clinical diagnosis was confirmed in three of these, while one was clinically diagnosed with corticobasal syndrome. In these patients, FE-PE2I binding was also normal in the substantia nigra (SN), while significantly reduced in the remaining patients. FE-PE2I measurement of the mean DAT availability in the putamen was strongly correlated with BPND in the SN (R = 0.816, p < 0.001). Olfaction and mean putamen DAT availability was correlated using both FE-PE2I BPND and FP-CIT SUR (R ≥ 0.616, p < 0.001).Conclusion: DAT imaging with FE-PE2I PET yields excellent basic diagnostic differentiation in early-stage PS, at least as good as FP-CIT SPECT.
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35.
  • Jakobson Mo, Susanna, et al. (författare)
  • VNTR polymorphism in the SLC6A3 gene does not influence dopamine transporter availability measured by [18F]FE-PE2I PET or [123I]FP-Cit SPECT
  • 2022
  • Ingår i: Nuclear medicine communications. - : Wolters Kluwer. - 0143-3636 .- 1473-5628. ; 43:3, s. 247-255
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To investigate the potential impact of polymorphism in the 3'-untranslated region (3'UTR) of the SLC6A3 gene (DAT1) on normal variation in dopamine transporter (DAT) imaging with [18F]FE-PE2I PET and [123I]FP-Cit SPECT.METHODS: Thirty-six individuals (mean age 70.4±5.4 years) with normal [18F]FE-PE2I PET and [123I]FP-Cit SPECT were genotyped for variable number of tandem repeats (VNTR) in the 3′UTR of the DAT1 gene. The DAT-availability in the caudate and putamen as measured with [18F]FE-PE2I PET and [123I]FP-Cit SPECT, as well as in the substantia nigra with [18F]FE-PE2I PET were compared between the participants carrying one or two 9-repeat alleles (i.e. 9R+10R or 9R+9R; 47%) and the participants without a 9R allele (i.e. 10R+10R or 10R+11R; 53%). Nonparametric tests, linear regression analysis and mixed model analysis were used to assess any statistical difference in measured DAT availability between the two allele groups.RESULTS: The measured DAT-availability in PET- and SPECT-imaging tended to be slightly higher in the 9R-group; however, the difference did not reach statistical significance in either the caudate or the putamen or the substantia nigra. Instead, age did have a significant effect on the DAT level (P < 0.05) notwithstanding the genotype.CONCLUSION: No significant effect of DAT1-genotype was detectable in imaging with [18F]FE-PE2I PET or [123I]FP-Cit, instead, age accounted for the normal variation in DAT-PET and DAT-SPECT.
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36.
  • Kihlstedt, Carl-Johan, et al. (författare)
  • Freezing of gait in idiopathic normal pressure hydrocephalus
  • 2024
  • Ingår i: Fluids and Barriers of the CNS. - : BioMed Central (BMC). - 2045-8118. ; 21:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Reports of freezing of gait (FoG) in idiopathic normal pressure hydrocephalus (iNPH) are few and results are variable. This study's objective was to evaluate the frequency of FoG in a large cohort of iNPH patients, identify FoG-associated factors, and assess FoG’s responsiveness to shunt surgery.Methods: Videotaped standardized gait protocols with iNPH patients pre- and post-shunt surgery (n = 139; median age 75 (71–79) years; 48 women) were evaluated for FoG episodes by two observers (Cohens kappa = 0.9, p < 0.001). FoG episodes were categorized. Mini-mental state examination (MMSE) and MRI white matter hyperintensities (WMH) assessment using the Fazekas scale were performed. CSF was analyzed for Beta-amyloid, Tau, and Phospho-tau. Patients with and without FoG were compared.Results: Twenty-two patients (16%) displayed FoG at baseline, decreasing to seven (8%) after CSF shunt surgery (p = 0.039). The symptom was most frequently exhibited during turning (n = 16, 73%). Patients displaying FoG were older (77.5 vs. 74.6 years; p = 0.029), had a slower walking speed (0.59 vs. 0.89 m/s; p < 0.001), a lower Tinetti POMA score (6.8 vs. 10.8; p < 0.001), lower MMSE score (21.3 vs. 24.0; p = 0.031), and longer disease duration (4.2 vs. 2.3 years; p < 0.001) compared to patients not displaying FoG. WMH or CSF biomarkers did not differ between the groups.Conclusions: FoG is occurring frequently in iNPH patients and may be considered a typical feature of iNPH. FoG in iNPH was associated with higher age, longer disease duration, worse cognitive function, and a more unstable gait. Shunt surgery seems to improve the symptom.
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37.
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38.
  • Levallius, Johanna, et al. (författare)
  • Who do you think you are? - Personality in eating disordered patients.
  • 2015
  • Ingår i: Journal of Eating Disorders. - : Springer Science and Business Media LLC. - 2050-2974. ; 3:3
  • Tidskriftsartikel (refereegranskat)abstract
    • The Five-Factor Model of personality is strongly linked to common mental disorders. Yet the relationship between the lower order personality traits (facets) of the model and eating disorder (ED) features remains unclear. The aim of the study was to explore how patients with non-anorexic ED differ from controls in personality and to examine the ability of personality facets to explain psychopathology.
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39.
  • Lidar, Julius, 1984- (författare)
  • Bioenergetic and Mechanical Modeling of Endurance Sports with Emphasis on Individualization
  • 2023
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Endurance athletes strive to improve their race times by enhancing their physical abilities, techniques, tactics, and equipment. Numerical simulations can aid in this effort by enabling repeated testing under identical conditions, thus isolating the effect of a single variable of interest on race time. This thesis outlines the mechanical assumptions and mathematical formulations to conducting numerical simulations. Paper I exemplifies applications and limitations when using numerical simulations with a propulsive power model, by investigating the impact of dynamic friction on race times in cross-country skiing.Further, the thesis introduces bioenergetic modeling as a possible method for more accurately modeling an athlete’s propulsive power. It provides an overview of existing bioenergetic models and describes a non-linear grey-box parameter estimation method for individualizing bioenergetic model formulations to reflect an individual athlete’s bioenergetic systems. In Paper II, an assessment of validation for two existing bioenergetic models is performed on an individual level when applied to simulated sprint time trials in cross-country skiing. The models show overall good agreement with measurement data but lack the ability to capture the dynamics of the human metabolic energy systems in more detail.In Paper III, a new bioenergetic model is developed which describes the dynamic behavior of the metabolic energy supply systems and various sources of metabolic demand. The model is individualized and validated against intermittent cycling with varying power output. Although the model shows good agreement with measurements, it does not capture the details of the aerobic slow component and periods of recovery, indicating a need for continued development.
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40.
  • Lindén, Magnus, et al. (författare)
  • A latent core of dark traits explains individual differences in peacekeepers’ unethical attitudes and conduct
  • 2019
  • Ingår i: Military Psychology. - : Informa UK Limited. - 0899-5605 .- 1532-7876. ; 31:6, s. 499-509
  • Tidskriftsartikel (refereegranskat)abstract
    • The influence of military members’ malevolent personality traits on their ethical attitudes and behaviors has been the subject of research for decades. We investigated the relationship between malevolent individual difference factors (Machiavellianism, narcissism, psychopathy, the dominance facet of social dominance orientation, and right-wing authoritarianism) and aspects of military ethics before and during a peacekeeping mission to Mali. Based on pre-service responses from 175 Swedish soldiers, a factor analysis revealed a latent variable to which all individual difference factors contributed. This latent “core of darkness” was related to being more positive toward unethical behaviors both in a warzone and in the Swedish military organization. Extending these findings using a sub-sample of the soldiers (n = 63), we also found that the latent darkness variable prospectively predicted a higher frequency of self-reported insulting and cursing of non-combatants while in Mali. Our results suggest that malevolent individual difference factors have a common core and that moral transgressions during peacekeeping can be predicted and perhaps minimized by identifying soldiers who score high on this common core. However, more research is needed to understand the unique relations of some malevolent factors and different types of morally questionable warzone behavior.
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41.
  • Maple-Grødem, Jodi, et al. (författare)
  • Lack of Association between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts
  • 2021
  • Ingår i: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 11:4, s. 1569-1578
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of developing motor complications compared to the general PD population.Objective: To evaluate the association of GBA carrier status with the development of LIDS and MFs from early PD.Methods: Motor complications were recorded prospectively in 884 patients with PD from four longitudinal cohorts using part IV of the UPDRS or MDS-UPDRS. Subjects were followed for up to 11 years and the associations of GBA mutations with the development of motor complications were assessed using parametric accelerated failure time models.Results: In 439 patients from Europe, GBA mutations were detected in 53 (12.1%) patients and a total of 168 cases of LIDs and 258 cases of MF were observed. GBA carrier status was not associated with the time to develop LIDs (HR 0.78, 95%CI 0.47 to 1.26, p = 0.30) or MF (HR 1.19, 95%CI 0.84 to 1.70, p = 0.33). In the American cohorts, GBA mutations were detected in 36 (8.1%) patients and GBA carrier status was also not associated with the progression to LIDs (HR 1.08, 95%CI 0.55 to 2.14, p = 0.82) or MF (HR 1.22, 95%CI 0.74 to 2.04, p = 0.43).Conclusion: This study does not provide evidence that GBA-carrier status is associated with a higher risk of developing motor complications. Publication of studies with null results is vital to develop an accurate summary of the clinical features that impact patients with GBA-associated PD.
  •  
42.
  • Mõttus, René, et al. (författare)
  • Comparability of self-reported conscientiousness across 21 countries
  • 2012
  • Ingår i: European Journal of Personality. - : SAGE Publications. - 1099-0984 .- 0890-2070. ; 26:3, s. 303-317
  • Tidskriftsartikel (refereegranskat)abstract
    • In cross-national studies, mean levels of self-reported phenomena are often not congruent with more objective criteria. One prominent explanation for such findings is that people make self-report judgements in relation to culture-specific standards (often called the reference group effect), thereby undermining the cross-cultural comparability of the judgements. We employed a simple method called anchoring vignettes in order to test whether people from 21 different countries have varying standards for Conscientiousness, a Big Five personality trait that has repeatedly shown unexpected nation-level relationships with external criteria. Participants rated their own Conscientiousness and that of 30 hypothetical persons portrayed in short vignettes. The latter type of ratings was expected to reveal individual differences in standards of Conscientiousness. The vignettes were rated relatively similarly in all countries, suggesting no substantial culture-related differences in standards for Conscientiousness. Controlling for the small differences in standards did not substantially change the rankings of countries on mean self-ratings or the predictive validities of these rankings for objective criteria. These findings are not consistent with mean self-rated Conscientiousness scores being influenced by culture-specific standards. The technique of anchoring vignettes can be used in various types of studies to assess the potentially confounding effects of reference levels.
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43.
  • Mõttus, René, et al. (författare)
  • The effect of response style on self-reported conscientiousness across 20 countries.
  • 2012
  • Ingår i: Personality & Social Psychology Bulletin. - : SAGE Publications. - 0146-1672 .- 1552-7433. ; 38:11, s. 1423-1436
  • Tidskriftsartikel (refereegranskat)abstract
    • Rankings of countries on mean levels of self-reported Conscientiousness continue to puzzle researchers. Based on the hypothesis that cross-cultural differences in the tendency to prefer extreme response categories of ordinal rating scales over moderate categories can influence the comparability of self-reports, this study investigated possible effects of response style on the mean levels of self-reported Conscientiousness in 22 samples from 20 countries. Extreme and neutral responding were estimated based on respondents’ ratings of 30 hypothetical people described in short vignettes. In the vignette ratings, clear cross-sample differences in extreme and neutral responding emerged. These responding style differences were correlated with mean self-reported Conscientiousness scores. Correcting self-reports for extreme and neutral responding changed sample rankings of Conscientiousness, as well as the predictive validities of these rankings for external criteria. The findings suggest that the puzzling country rankings of self-reported Conscientiousness may to some extent result from differences in response styles.
  •  
44.
  • Nevatte, Tracy, et al. (författare)
  • ISPMD consensus on the management of premenstrual disorders
  • 2013
  • Ingår i: Archives of Women's Mental Health. - : Springer Science and Business Media LLC. - 1434-1816 .- 1435-1102. ; 16:4, s. 279-291
  • Tidskriftsartikel (refereegranskat)abstract
    • The second consensus meeting of the International Society for Premenstrual Disorders (ISPMD) took place in London during March 2011. The primary goal was to evaluate the published evidence and consider the expert opinions of the ISPMD members to reach a consensus on advice for the management of premenstrual disorders. Gynaecologists, psychiatrists, psychologists and pharmacologists each formally presented the evidence within their area of expertise; this was followed by an in-depth discussion leading to consensus recommendations. This article provides a comprehensive review of the outcomes from the meeting. The group discussed and agreed that careful diagnosis based on the recommendations and classification derived from the first ISPMD consensus conference is essential and should underlie the appropriate management strategy. Options for the management of premenstrual disorders fall under two broad categories, (a) those influencing central nervous activity, particularly the modulation of the neurotransmitter serotonin and (b) those that suppress ovulation. Psychotropic medication, such as selective serotonin reuptake inhibitors, probably acts by dampening the influence of sex steroids on the brain. Oral contraceptives, gonadotropin-releasing hormone agonists, danazol and estradiol all most likely function by ovulation suppression. The role of oophorectomy was also considered in this respect. Alternative therapies are also addressed, with, e.g. cognitive behavioural therapy, calcium supplements and Vitex agnus castus warranting further exploration.
  •  
45.
  • Nilsson, Johanna, 1993, et al. (författare)
  • Cerebrospinal fluid biomarkers of synaptic dysfunction are altered in Parkinson's disease and related disorders
  • 2023
  • Ingår i: Movement Disorders. - : John Wiley & Sons. - 0885-3185 .- 1531-8257. ; 38:2, s. 267-277
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Synaptic dysfunction and degeneration are central contributors to the pathogenesis and progression of parkinsonian disorders. Therefore, identification and validation of biomarkers reflecting pathological synaptic alterations are greatly needed and could be used in prognostic assessment and to monitor treatment effects.Objective: To explore candidate biomarkers of synaptic dysfunction in Parkinson's disease (PD) and related disorders.Methods: Mass spectrometry was used to quantify 15 synaptic proteins in two clinical cerebrospinal fluid (CSF) cohorts, including PD (n1 = 51, n2 = 101), corticobasal degeneration (CBD) (n1 = 11, n2 = 3), progressive supranuclear palsy (PSP) (n1 = 22, n2 = 21), multiple system atrophy (MSA) (n1 = 31, n2 = 26), and healthy control (HC) (n1 = 48, n2 = 30) participants, as well as Alzheimer's disease (AD) (n2 = 23) patients in the second cohort.Results: Across both cohorts, lower levels of the neuronal pentraxins (NPTX; 1, 2, and receptor) were found in PD, MSA, and PSP, compared with HC. In MSA and PSP, lower neurogranin, AP2B1, and complexin-2 levels compared with HC were observed. In AD, levels of 14-3-3 zeta/delta, beta- and gamma-synuclein were higher compared with the parkinsonian disorders. Lower pentraxin levels in PD correlated with Mini-Mental State Exam scores and specific cognitive deficits (NPTX2; rho = 0.25–0.32, P < 0.05) and reduced dopaminergic pre-synaptic integrity as measured by DaTSCAN (NPTX2; rho = 0.29, P = 0.023). Additionally, lower levels were associated with the progression of postural imbalance and gait difficulty symptoms (All NPTX; β-estimate = −0.025 to −0.038, P < 0.05) and cognitive decline (NPTX2; β-estimate = 0.32, P = 0.021).Conclusions: These novel findings show different alterations of synaptic proteins in parkinsonian disorders compared with AD and HC. The neuronal pentraxins may serve as prognostic CSF biomarkers for both cognitive and motor symptom progression in PD. 
  •  
46.
  • Norman, Peter, et al. (författare)
  • Opportunities, problems and solutions when instrumenting a machine tool for monitoring of cutting forces and vibrations
  • 2003
  • Ingår i: Laser metrology and machine performance, VI. - Southampton : WIT Press. - 1853129909 ; , s. 557-567
  • Konferensbidrag (refereegranskat)abstract
    • The ability to monitor the behaviour of machine tools and cutting processes is important both from a research perspective as well as in industrial applications such as adaptive control, condition monitoring, process optimization and quality control. The division of Manufacturing Engineering at Lulea University of Technology has been carrying out research in the area of high speed and multi axis (5-axis) machining since the mid 1990s. This European and nationally funded research, much of it carried out with Nottingham University and Sandvik Coromant, as well as in manufacturing companies in Sweden and the UK, has focused on understanding the possibilities offered by 5-axis/high-speed machining, as well as understanding the machining process. This initially empirical work has become more qualitative through the development of an instrumented machine tool test bed based on a 5-axis Leichti Turbomill equipped with a 24,000 rpm spindle and fast controller. The machine installation costs approximately 1.000.000 USD. The instrumentation that has been implemented includes piezo-electric force transducers in the machine table whilst ongoing work will move the research focus towards monitoring vibration in the workplace for which accelerometers and acoustic emission sensors will be used. The work presented will highlight the problems and solutions involved in creating the present test bed as well as indicating future research directions and challenges
  •  
47.
  • Qvarfordt, Anna, 1965- (författare)
  • Anti-doping – a legitimate effort? : Elite athletes' perspectives on policy and practice
  • 2019
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The global anti-doping enterprise in sport is a comprehensive system in which the athlete is at the centre of regulation, scrutiny and control. There is limited knowledge about the implications of this extensive control system for athletes and about how athletes perceive the system; little is known about possible consequences of these implications and perceptions for the legitimacy of the system. The overall aim of this thesis is to analyse the legitimacy of global anti-doping policy and practice from the perspectives of international elite athletes.Four articles are included in this compilation thesis. The first illustrates, based on a discourse analytical approach, how claims for legitimacy of the anti-doping system are produced in policy documents aimed at athletes. The second explores the perceptions and legitimacy of anti-doping policy and practice through a survey aimed at elite athletes in different sports and from different regions of the world. The third article examines, through an interview study, how athletes in different contexts experience the practice of anti-doping and what consequences this may have for the system's legitimacy. The interview study was also the basis for the fourth article, focusing on the athletes' experiences and perceptions of their opportunities for compliance and how this is related to their view of the system's legitimacy. Using the four articles as a basis, the analysis of legitimacy within the anti-doping system is expanded in the thesis through an overarching analytical framework inspired by David Beetham.The results show that the legitimacy of the policy documents is based on essentially authoritative, but also rational, arguments for justifying the anti-doping enterprise. Elite athletes are generally in favour of anti-doping policy and the principle that doping should be prohibited. However, when the rules are implemented into practice, problems to do with lack of procedural justice arise which may have an impact on the system's legitimacy. Procedures in the system are perceived as having a negative effect on sportspersons' private life, and as ineffective and unequally implemented across the world; also, athletes have little influence over decision-making processes. Anti-doping practice is moreover perceived to cause structural inequalities due to inequality in access to technology, education and knowledge as well as supportive systems. Most athletes wish to comply with the rules, but many struggle with lack of control and have limited scope for taking responsibility regarding compliance with the doping rules. Even when athletes are dutiful and perform acts that confer legitimacy to the rules and the authorities, some experiences and perceptions could endanger the legitimacy of antidoping, as seen in the overall legitimacy analysis of the thesis. Athletes' perceptions of inequality, ineffectiveness and lack of leeway can be interpreted as a lack of rule conformity to the anti-doping authority. There also appears to be a lack of shared normative beliefs between sportspersons and the anti-doping authorities, as many athletes feel that their opinions are not taken into account. Decision-making processes that do not pay attention to the perceptions of those involved can result in a discrepancy between the rules and the norms.The international anti-doping system is a major international enterprise with comprehensive rules that need to be applied equally around the world, and that also need to be legitimated in different countries where athletes have different conditions to comply with the regulations. In this thesis, I have shown that these different conditions have consequences for the ability to comply with the rules and also for the application of the regulations. The far-reaching rules mean that procedures within the system are experienced as causing a number of negative consequences. I have shown that this poses a risk to the legitimacy of the system if these problems are not addressed.
  •  
48.
  • Qvarfordt, Anna, 1965-, et al. (författare)
  • From fighting the bad to protecting the good : Legitimation strategies in WADA’s athlete guides
  • 2019
  • Ingår i: Performance Enhancement & Health. - : Elsevier. - 2211-2669. ; 7:1-2
  • Tidskriftsartikel (refereegranskat)abstract
    • The global anti-doping effort in sport is based upon perceptions of the system as desirable, proper and appropriate and thus considered legitimate. The legitimacy of the anti-doping system has earlier been studied bottom-up, based on the views of athletes. In order to gain greater understanding of legitimation processes, it is also important to study legitimation strategies top-down, used by decision-making and governing bodies. The aim of this study was to use Fairclough’s critical discourse analytical approach to analyse the social construction of legitimacy in the World Anti-Doping Agency’s three editions of a guide to anti-doping rules aimed at athletes. The analysis was performed based on van Leeuwen’s four specific legitimation strategies: authorization, rationalization, moral evaluation and mythopoesis. Our analysis shows that the legitimation of the anti-doping discourse as constructed in the athlete guides that has accompanied anti-doping regulations for more than a decade is characterized by continuity as regards an authoritarian attitude, but also by change towards a more rational and athlete-centred stance. A shift can be seen in the construction of legitimacy in the anti-doping discourse from “fighting the bad” to “protecting the good”. We discuss the moral evaluation strategy as a way to construct legitimacy for anti-doping efforts and sport in general towards a wider public. In the light of the results of this study, we conclude that policymaking in relation to doping issues should take into account the dimension of the discursive top-down legitimation, which could affect how the policy is received at the level of the athletes and provide conditions for a sustainable anti-doping system.
  •  
49.
  • Qvarfordt, Anna, 1965-, et al. (författare)
  • From fighting the bad to protecting the good : legitimation discourses in WADA’s athlete guides
  • 2019
  • Ingår i: Performance Enhancement & Health. - : Elsevier. - 2211-2669. ; 7:1-2
  • Tidskriftsartikel (refereegranskat)abstract
    • The global anti-doping effort in sport is based upon perceptions of the system as desirable, proper and appropriate and thus considered legitimate. The legitimacy of the anti-doping system has earlier been studied bottom-up, based on the views of athletes. In order to gain greater understanding of legitimation processes, it is also important to study legitimation strategies top-down, used by decision-making and governing bodies. The aim of this study was to use Fairclough's critical discourse analytical approach to analyse the social construction of legitimacy in the World Anti-Doping Agency's three editions of a guide to anti-doping rules aimed at athletes. The analysis was performed based on van Leeuwen's four specific legitimation strategies: authorization, rationalization, moral evaluation and mythopoesis. Our analysis shows that the legitimation of the anti-doping discourse as constructed in the athlete guides that has accompanied anti-doping regulations for more than a decade is characterized by continuity as regards an authoritarian attitude, but also by change towards a more rational and athlete-centred stance. A shift can be seen in the construction of legitimacy in the anti-doping discourse from “fighting the bad” to “protecting the good”. We discuss the moral evaluation strategy as a way to construct legitimacy for anti-doping efforts and sport in general towards a wider public. In the light of the results of this study, we conclude that policymaking in relation to doping issues should take into account the dimension of the discursive top-down legitimation, which could affect how the policy is received at the level of the athletes and provide conditions for a sustainable anti-doping system. 
  •  
50.
  • Qvarfordt, Anna, 1965-, et al. (författare)
  • Limitations and duties : elite athletes’ perceptions of compliance with anti-doping rules
  • 2021
  • Ingår i: Sport in Society. - : Informa UK Limited. - 1743-0437 .- 1743-0445. ; 24:4, s. 551-570
  • Tidskriftsartikel (refereegranskat)abstract
    • The main purpose of this article is to examine how elite athletes perceive their own responsibilities and possibilities to be compliant with the anti-doping regulations, and to draw conclusions about what these perceptions mean in relation to the legitimacy of the anti-doping system. A qualitative research design, with interviews conducted with athletes globally, was employed to capture elite sportspersons’ views on anti-doping policy and procedures. The analysis was based on a theoretical framework on legitimacy. The findings show that athletes’ situation is characterized by limited information and a lack of leeway. At the same time, athletes find themselves obliged to be dutiful. We discuss the complex situation of simultaneously facing perceived limitations and duties, and consider the limits that athletes experience in relation to compliance, which may place the legitimacy of the anti-doping system at risk.
  •  
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