| 1. |
- Breznau, Nate, et al.
(författare)
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Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:44
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Tidskriftsartikel (refereegranskat)abstract
- This study explores how researchers analytical choices affect the reliability of scientific findings. Most discussions of reliability problems in science focus on systematic biases. We broaden the lens to emphasize the idiosyncrasy of conscious and unconscious decisions that researchers make during data analysis. We coordinated 161 researchers in 73 research teams and observed their research decisions as they used the same data to independently test the same prominent social science hypothesis: that greater immigration reduces support for social policies among the public. In this typical case of social science research, research teams reported both widely diverging numerical findings and substantive conclusions despite identical start conditions. Researchers expertise, prior beliefs, and expectations barely predict the wide variation in research outcomes. More than 95% of the total variance in numerical results remains unexplained even after qualitative coding of all identifiable decisions in each teams workflow. This reveals a universe of uncertainty that remains hidden when considering a single study in isolation. The idiosyncratic nature of how researchers results and conclusions varied is a previously underappreciated explanation for why many scientific hypotheses remain contested. These results call for greater epistemic humility and clarity in reporting scientific findings.
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| 2. |
- Mossmann, Dirk, et al.
(författare)
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Amyloid-beta Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation
- 2014
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Ingår i: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 20:4, s. 662-669
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Tidskriftsartikel (refereegranskat)abstract
- Most mitochondrial proteins possess N-terminal presequences that are required for targeting and import into the organelle. Upon import, presequences are cleaved off by matrix processing peptidases and subsequently degraded by the peptidasome Cym1/PreP, which also degrades Amyloid-beta peptides (A beta). Here we find that impaired turnover of presequence peptides results in feedback inhibition of presequence processing enzymes. Moreover, A beta inhibits degradation of presequence peptides by PreP, resulting in accumulation of mitochondrial preproteins and processing intermediates. Dysfunctional preprotein maturation leads to rapid protein degradation and an imbalanced organellar proteome. Our findings reveal a general mechanism by which A beta peptide can induce the multiple diverse mitochondrial dysfunctions accompanying Alzheimer's disease.
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| 3. |
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Consumption and Advertising in Eastern Europe and Russia in the Twentieth Century
- 2023. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This book explores Eastern European consumer cultures in the twentieth century, taking a comparative perspective and conceptualizing the peculiarities of consumption in the region. Contributions cover lifestyles and marketing strategies in imperial contexts in the late nineteenth and early twentieth centuries; urban consumer cultures in the Interwar Period; and consumer and advertising cultures in the Soviet Union and its satellite republics. It traces the development of marketing throughout the century, and the changes in society brought about by democratization and the 'Americanization' of consumption. Taken together, the essays gathered here make a valuable contribution to our understanding of consumption and advertising in the region.
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| 4. |
- Eriksroed-Burger, M., et al.
(författare)
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Preface
- 2023
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Ingår i: Consumption and Advertising in Eastern Europe and Russia in the Twentieth Century. - : Springer. - 9783031202049 ; , s. v-vi
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Bokkapitel (refereegranskat)
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| 5. |
- Malitska, Julia, et al.
(författare)
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Consuming and Advertising in Eastern Europe and Russia in the Twentieth Century : Introductory Remarks
- 2023. - 1
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Ingår i: Consumption and Advertising in Eastern Europe and Russia in the Twentieth Century. - Cham : Palgrave Macmillan. - 9783031202032 - 9783031202049 ; , s. 3-29
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Bokkapitel (refereegranskat)abstract
- Acknowledging that Eastern European and Russian consumerism not only adopted and aligned Western attitudes, but also developed own ways of negotiating consumption and through that their own lifestyle in modernity, the chapter launches the conceptual framework of Consuming and Advertising by deconstructing prevalent images of nearly non-existent consumerism there. By the turn to twentieth century, different consumption patterns were negotiated differently across these societies, even if products were similar. The establishment of Soviet power can be outlined as an anti-consumerism project, but particular socialist forms of consumption and advertisements emerged, spreading the image of the “socialist world” and socialist ideas of consuming and advertising. These forms deeply shaped everyday life, since consumer goods were considered by the people as the most important part of the promised “good life”, consumption and advertisement were instrumentalized to proof that promise. Hence, the chapter considers consumption as a cultural practice that reflects values and norms, but also political attitudes, and tool of soft power, while advertisements want to trigger the desires of the consumers. Both consumption and advertisement represent and trigger habitus and self-perception in a society and were used to mobilize the population in favor of the state and nation.
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| 6. |
- Prost, Stefan, et al.
(författare)
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Genomic analyses show extremely perilous conservation status of African and Asiatic cheetahs (Acinonyx jubatus)
- 2022
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Ingår i: Molecular Ecology. - : John Wiley & Sons. - 0962-1083 .- 1365-294X. ; 31:16, s. 4208-4223
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Tidskriftsartikel (refereegranskat)abstract
- We live in a world characterized by biodiversity loss and global environmental change. The extinction of large carnivores can have ramifying effects on ecosystems like an uncontrolled increase in wild herbivores, which in turn can have knock-on impacts on vegetation regeneration and communities. Cheetahs (Acinonyx jubatus) serve important ecosystem functions as apex predators; yet, they are quickly heading towards an uncertain future. Threatened by habitat loss, human-wildlife conflict and illegal trafficking, there are only approximately 7100 individuals remaining in nature. We present the most comprehensive genome-wide analysis of cheetah phylogeography and conservation genomics to date, assembling samples from nearly the entire current and past species' range. We show that their phylogeography is more complex than previously thought, and that East African cheetahs (A. j. raineyi) are genetically distinct from Southern African individuals (A. j. jubatus), warranting their recognition as a distinct subspecies. We found strong genetic differentiation between all classically recognized subspecies, thus refuting earlier findings that cheetahs show only little differentiation. The strongest differentiation was observed between the Asiatic and all the African subspecies. We detected high inbreeding in the Critically Endangered Iranian (A. j. venaticus) and North-western (A. j. hecki) subspecies, and show that overall cheetahs, along with snow leopards, have the lowest genome-wide heterozygosity of all the big cats. This further emphasizes the cheetah's perilous conservation status. Our results provide novel and important information on cheetah phylogeography that can support evidence-based conservation policy decisions to help protect this species. This is especially relevant in light of ongoing and proposed translocations across subspecies boundaries, and the increasing threats of illegal trafficking.
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| 7. |
- Zaniew, Marcin, et al.
(författare)
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Long-term renal outcome in children with OCRL mutations : Retrospective analysis of a large international cohort
- 2018
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Ingår i: Nephrology Dialysis Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 33:1, s. 85-94
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Tidskriftsartikel (refereegranskat)abstract
- Background. Lowe syndrome (LS) and Dent-2 disease (DD2) are disorders associated with mutations in the OCRL gene and characterized by progressive chronic kidney disease (CKD). Here, we aimed to investigate the long-term renal outcome and identify potential determinants of CKD and its progression in children with these tubulopathies. Methods. Retrospective analyses were conducted of clinical and genetic data in a cohort of 106 boys (LS: 88 and DD2: 18). For genotype-phenotype analysis, we grouped mutations according to their type and localization. To investigate progression of CKD we used survival analysis by Kaplan-Meier method using stage 3 CKD as the end-point. Results. Median estimated glomerular filtration rate (eGFR) was lower in the LS group compared with DD2 (58.8 versus 87.4 mL/min/1.73 m2, P < 0.01). CKD stage II-V was found in 82% of patients, of these 58% and 28% had moderate-to-severe CKD in LS and DD2, respectively. Three patients (3%), all with LS, developed stage 5 of CKD. Survival analysis showed that LS was also associated with a faster CKD progression than DD2 (P < 0.01). On multivariate analysis, eGFR was dependent only on age (b0.46, P < 0.001). Localization, but not type of mutations, tended to correlate with eGFR. There was also no significant association between presence of nephrocalcinosis, hypercalciuria, proteinuria and number of adverse clinical events and CKD. Conclusions. CKD is commonly found in children with OCRL mutations. CKD progression was strongly related to the underlying diagnosis but did not associate with clinical parameters, such as nephrocalcinosis or proteinuria.
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