| 1. |
- Hesselmar, Bill, 1955, et al.
(författare)
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Building characteristics affect the risk of allergy development
- 2005
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Ingår i: Pediatr Allergy Immunol. - : Wiley. - 0905-6157 .- 1399-3038. ; 16:2, s. 126-31
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Tidskriftsartikel (refereegranskat)abstract
- Damp dwellings increase the risk for house dust mite (HDM) infestation in temperate climate zones and may be associated with an increased risk for allergic disease. The aim of the study was to assess possible relationships between allergen levels in house dust, characteristics of residence buildings and allergic diseases in children. A subsample of 12-yr-old children, having the same address in 1991 and 1996, was selected from a population-based sample of children from the Goteborg area. Health inspectors examined the residences of all the 109 children and several different building characteristics including humidity and indoor temperature were collected. Dust samples for analysis of HDM allergens were collected from the children's beds, and for analysis of cat and dog allergens from the living room. Current health status was assessed by questionnaires, interviews and skin prick tests (SPT). Dog or cat allergens were found in all houses, even in houses without such animals. HDM allergens were found in 60% of the houses, but only six of them had levels exceeding 2 microg/g dust. There was a strong association between HDM-infestation and wheeze, but not with specific sensitization to HDM. The type of building (houses when compared with flats), the ventilation system and the presence of a basement had all major implications on respiratory symptoms, atopy and HDM infestation. We can conclude that dog or cat allergens were found in all houses, and a strong association between HDM infestation and indoor environment. Building construction affected both respiratory morbidity and sensitisation independently, suggesting not only worsening of symptoms but also a causative relationship with disease development.
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| 4. |
- Bjorksten, B, et al.
(författare)
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Is allergy a preventable disease?
- 2000
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Ingår i: Advances in experimental medicine and biology. - Boston : Kluwer Academic Publishers. - 0065-2598. ; 478, s. 109-120
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Morales, E, et al.
(författare)
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Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: ISAAC phase III
- 2019
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Ingår i: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 74:6, s. 531-538
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Tidskriftsartikel (refereegranskat)abstract
- Asthma is not the key focus of prevention strategies. A Healthy Lifestyle Index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) phase III.MethodsInformation on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis and eczema was evaluated using multilevel mixed-effects logistic regression models.FindingsData of 70 795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR 0.87, 95% CI 0.84 to 0.89), asthma ever (OR 0.89, 95% CI 0.87 to 0.92), current symptoms of rhinoconjunctivitis (OR 0.95, 95% CI 0.92 to 0.97) and current symptoms of eczema (OR 0.92, 95% CI 0.92 to 0.98). Theoretically, if associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16% of asthma cases (ranging from 2.7% to 26.3 % according to region of the world).ConclusionsThese findings should be interpreted with caution given the limitations to infer causality from cross-sectional observational data. Efficacy of interventions to improve multiple modifiable lifestyle factors to reduce the burden asthma and allergy in childhood should be assessed.
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| 18. |
- Abrahamsson, Thomas, et al.
(författare)
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A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization
- 2011
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Ingår i: Clinical and Experimental Allergy. - : Blackwell Publishing. - 0954-7894 .- 1365-2222. ; 41:12, s. 1729-1739
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Tidskriftsartikel (refereegranskat)abstract
- Background Analyses of circulating chemokines offer novel tools to investigate the T helper (Th)1/Th2 imbalance in allergic disease in vivo. less thanbrgreater than less thanbrgreater thanObjective To relate circulating Th1- and Th2-associated chemokines in infancy to allergic disease, sensitization and probiotic supplementation. less thanbrgreater than less thanbrgreater thanMethods Circulating levels of Th1-associated CXC-chemokine ligand (CXCL) 9, CXCL10 and CXCL11 and Th2-associated CC-chemokine ligand (CCL)17 and CCL22 were assessed with Luminex and CCL18 with enzyme-linked immunosorbent assay at birth (n = 109), 6 (n = 104), 12 (n = 116) and 24 months (n = 123) in 161 infants completing a double-blind placebo-controlled allergy prevention trial with Lactobacillus reuteri during the last month of gestation and through the first year of life. The infants were followed regarding the development of allergic disease and sensitization until 2 years of age. less thanbrgreater than less thanbrgreater thanResults The Th2-associated chemokines CCL17 and CCL22 were the highest at birth and then decreased, whereas CCL18 and the Th1-associated chemokines increased with age. High Th2-associated chemokine levels were observed in children developing allergic disease. Sensitization was preceded by elevated levels of the Th2-associated CCL22 and reduced levels of the Th1-associated CXCL11 already at birth. The Th2-associated CCL17 was also elevated at birth in infants developing recurrent wheeze. A high Th2/Th1 ratio (CCL22/CXCL10) at birth associated with both sensitization and eczema development. The presence of L. reuteri in stool in the first week of life was associated with low CCL17 and CCL22 and high CXCL11 levels at 6 months of age. High Th1-associated chemokine levels were associated with day-care. less thanbrgreater than less thanbrgreater thanConclusion and Clinical Relevance Allergic disease and sensitization in infancy was associated with low circulating Th1- and high Th2-associated chemokine levels already from birth. Circulating chemokines are useful for investigating the Th1/Th2 imbalance in allergic disease in vivo. Elucidation of the role of chemokines in allergic diseases may lead to future treatments.
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| 20. |
- Abrahamsson, Thomas, et al.
(författare)
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A Th1/Th2-associated chemokine imbalance preceding allergic disease is influenced by birth size, breastfeeding, daycare and probiotics
- 2009
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Ingår i: in Allergy, vol 64. ; , s. 56-56
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Konferensbidrag (refereegranskat)abstract
- Background: Analyses of circulating chemokines offer novel tools to investigate the Th1/Th2 imbalance in allergic disease in vivo and explore the influence of pre- and postnatal factors in infancy. Objective: To relate circulating Th1- and Th2-associated chemokines to the development of allergic disease, pre- and postnatal factors and probiotic supplementation in infancy. Methods: Circulating levels of Th1-associated CXC-chemokine ligand (CXCL)9, CXCL10 and CXCL11 and Th2-associated CC-chemokine ligand (CCL)17, CCL18 and CCL22 were assessed with Luminex and ELISA at birth (n=109), 6 (n=104), 12 (n=116) and 24 months (n=123) in 179 infants completing a double-blind placebo-controlled allergy prevention trial with Lactobacillus reuteri during the last month of gestation and through the first year of life. The infants were followed regarding development of allergic disease and sensitization until two years of age. Results: The Th2-associated chemokines were as highest at birth and then decreased, whereas the Th1-associated chemokines increased with age. Low Th1- and high Th2-associated chemokine levels were observed in children developing allergic disease. Sensitization was preceded by elevated CCL22 and reduced CXCL11 levels. High Th2-associated chemokine46 levels were associated with increased birth length and weight and long duration of breastfeeding, and high Th1-associated chemokine levels with day-care attendance. Presence of L. reuteri in stool the first week of life was associated with low CCL17 and CCL22 and high CXCL11 levels at 6 months. Conclusion: Allergic disease in infancy was associated with low circulating Th1- and high Th2-associated chemokine levels during the first year of life. The chemokine levels were affected by both pre and –postnatal factors.
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| 23. |
- Abrahamsson, TR, et al.
(författare)
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Reply: To PMID 22153774
- 2013
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Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 131:1, s. 248-249
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 24. |
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| 25. |
- Anderson, HR, et al.
(författare)
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Immunization and symptoms of atopic disease in children: results from the International Study of Asthma and Allergies in Childhood
- 2001
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Ingår i: American journal of public health. - : American Public Health Association. - 0090-0036 .- 1541-0048. ; 91:7, s. 1126-1129
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: This study tested the hypothesis that immunization is related to the prevalence of atopic disease in childhood. METHODS: We used data from the International Study of Asthma and Allergies in Childhood to perform an ecologic analysis of national and local immunization rates for tuberculosis, diphtheria and tetanus toxoids and pertussis (DTP), and measles and prevalence of atopic disease symptoms (asthma, allergic rhinoconjunctivitis, and atopic eczema). RESULTS: In 13- to 14-year-old children, there were significant negative associations with local birth-year immunization rates for DTP and measles but none with rates for tuberculosis. No associations were found in 6- to 7-year-old children. No associations with national immunization rates were found. CONCLUSIONS: International variations in childhood atopic diseases are unlikely to be explained by variations in immunization.
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| 37. |
- Bjorksten, B
(författare)
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Allergy priming early in life
- 1999
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Ingår i: Lancet (London, England). - 0140-6736. ; 353:9148, s. 167-168
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Tidskriftsartikel (refereegranskat)
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| 38. |
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| 39. |
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| 40. |
- Bjorksten, B
(författare)
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Early immune responses to allergens
- 1997
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Ingår i: International archives of allergy and immunology. - 1018-2438. ; 113:1-3, s. 80-82
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Tidskriftsartikel (refereegranskat)
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| 41. |
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| 42. |
- Bjorksten, B
(författare)
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Environment and infant immunity
- 1999
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Ingår i: The Proceedings of the Nutrition Society. - 0029-6651. ; 58:3, s. 729-732
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Tidskriftsartikel (refereegranskat)
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| 43. |
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| 44. |
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| 45. |
- Bjorksten, B
(författare)
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Environmental risk factors for atopy
- 1997
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Ingår i: Clinical reviews in allergy & immunology. - 1080-0549. ; 15:2, s. 125-143
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Tidskriftsartikel (refereegranskat)
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| 46. |
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| 47. |
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| 48. |
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| 49. |
- Bjorksten, B
(författare)
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How allergenic is food?
- 2004
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Ingår i: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. - : Wiley. - 0954-7894. ; 34:5, s. 673-675
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 50. |
- Bjorksten, B
(författare)
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Immunological outcome measures
- 1996
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Ingår i: EUROPEAN RESPIRATORY JOURNAL. - 0903-1936. ; 9, s. S22-S27
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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