| 1. |
|
|
| 2. |
|
|
| 3. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 4. |
|
|
| 5. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Barber, R. M., et al.
(författare)
-
Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015 : A novel analysis from the global burden of disease study 2015
- 2017
-
Ingår i: The Lancet. - : Lancet Publishing Group. - 0140-6736 .- 1474-547X. ; 390:10091, s. 231-266
-
Tidskriftsartikel (refereegranskat)abstract
- Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. Methods We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure-the Healthcare Quality and Access (HAQ) Index-on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Findings Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0-42·8) in 1990 to 53·7 (52·2-55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. Interpretation This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Copyright © The Author(s). Published by Elsevier Ltd.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Gornov, MG, et al.
(författare)
-
A charged particle spectrometer for small-angle experiments
- 1999
-
Ingår i: INSTRUMENTS AND EXPERIMENTAL TECHNIQUES. - : PLENUM PUBL CORP. - 0020-4412. ; 42:4, s. 493-499
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A high-purity germanium spectrometer for detecting long-range charged particles emitted at small angles is described. The spectrometer is intended for investigations of two-body nuclear reactions on the internal targets of the CELSIUS storage ring. It is
|
|
| 17. |
|
|
| 18. |
- James, SL, et al.
(författare)
-
Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
- 2020
-
Ingår i: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 96-114
-
Tidskriftsartikel (refereegranskat)abstract
- Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.MethodsWe reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).FindingsIn 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).InterpretationInjuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
|
|
| 19. |
|
|
| 20. |
- Liu, Kun, et al.
(författare)
-
A study of intrinsic amorphous silicon thin film deposited on flexible polymer substrates by magnetron sputtering
- 2016
-
Ingår i: Journal of Non-Crystalline Solids. - : Elsevier BV. - 0022-3093 .- 1873-4812. ; 449, s. 125-132
-
Tidskriftsartikel (refereegranskat)abstract
- Amorphous silicon (a-Si) has gained its popularity in thin film Solar cell fabrication for its high absorption coefficient, high applicability on flexible substrates and practical feasibility for low-cost roll-to-roll mass fabrication. Working as the intrinsic layer, the optical-electrical characteristics of amorphous silicon film is crucial to the cell performance. In this work, the amorphous silicon film has been fabricated on PET substrate by magnetron sputtering method. The main optical-electrical characteristics have been systematically investigated under different fabrication conditions (sputtering power, working pressure, working temperature). The results indicate that the deposition rate increases remarkably from 1.88 to 834 nm/min with the sputtering power increasing from 60 W to 120 W, while the light transmission rate decreases from 86% to 46% in the visible spectrum range (390 nm to 780 nm). Theoretical calculations have been carried out, showing a decreasing deposition rate under an increasing working pressure. A rising temperature provides a higher deposition rate and lower trans-mittance in the certain range. The optimized processing parameters in the fabrication of amorphous silicon thin film are obtained for high photoelectric property on flexible substrates.
|
|
| 21. |
- Liu, Kun, et al.
(författare)
-
B-Doped Amorphous Silicon Thin Films Deposited on Flexible PET Substrate by Magnetron Sputtering
- 2015
-
Ingår i: Journal of Computational and Theoretical Nanoscience. - : American Scientific Publishers. - 1546-1955 .- 1546-1963. ; 12:9, s. 2931-2936
-
Tidskriftsartikel (refereegranskat)abstract
- Depositing amorphous silicon doped with different elements on flexible substrates offers a large potential for the roll-to-roll processes lowering the manufacturing cost of solar cells. Unique magnetron sputtering method was adopted to deposit B-doped amorphous silicon thin film on flexible PET substrate instead of solid substrate materials like glass, metal and silicon. Effects of different substrates were investigated, as well as the processing parameters including sputtering power and working pressure. The structure and performance of the samples were characterized with SEM, XRD, surface profile meter and UV-spectrophotometer. The comparison between PET and glass shows that the alternative of PET substrate significantly improved the deposition rate. Optimal results were obtained as pressure of 0.2 Pa and RF power of 120 W, which showed the lowest transmittance as well as a minimum optical band gap, both are of great significance to photovoltaic conversion. Theoretical justification and experimental data including the feasible magnetron sputtering way, PET flexible substrate and optimized process parameters to the mass production of cheap and high performance heterojunction thin film solar cells were achieved.
|
|
| 22. |
- Menden, MP, et al.
(författare)
-
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- 2019
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2674-
-
Tidskriftsartikel (refereegranskat)abstract
- The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
|
|
| 23. |
- Mishra, A, et al.
(författare)
-
Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
-
Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
- Schael, S, et al.
(författare)
-
Precision electroweak measurements on the Z resonance
- 2006
-
Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
-
Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
|
|
| 29. |
- Scherer, SW, et al.
(författare)
-
Human chromosome 7: DNA sequence and biology
- 2003
-
Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
-
Tidskriftsartikel (refereegranskat)abstract
- DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
- Glasbey, JC, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 35. |
- Aartsen, M. G., et al.
(författare)
-
Evidence for High-Energy Extraterrestrial Neutrinos at the IceCube Detector
- 2013
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 342:6161, s. 947-
-
Tidskriftsartikel (refereegranskat)abstract
- We report on results of an all-sky search for high-energy neutrino events interacting within the IceCube neutrino detector conducted between May 2010 and May 2012. The search follows up on the previous detection of two PeV neutrino events, with improved sensitivity and extended energy coverage down to about 30 TeV. Twenty-six additional events were observed, substantially more than expected from atmospheric backgrounds. Combined, both searches reject a purely atmospheric origin for the 28 events at the 4 sigma level. These 28 events, which include the highest energy neutrinos ever observed, have flavors, directions, and energies inconsistent with those expected from the atmospheric muon and neutrino backgrounds. These properties are, however, consistent with generic predictions for an additional component of extraterrestrial origin.
|
|
| 36. |
- Abazov, V. M., et al.
(författare)
-
Search for W' -> tb resonances with left- and right-handed couplings to fermions D0 Collaboration
- 2011
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 699:3, s. 145-150
-
Tidskriftsartikel (refereegranskat)abstract
- We present a search for the production of a heavy gauge boson, W', that decays to third-generation quarks, by DO Collaboration in p (p) over bar) collisions at root s = 1.96 TeV. We set 95% confidence level upper limits on the production cross section times branching fraction. For the first time, we set limits for arbitrary combinations of left-and right-handed couplings of the W' boson to fermions. For couplings with the same strength as for the standard model W boson, we set the following limits, assuming that there are right-handed neutrinos nu(R) for all three generations with M(W') > m(nu(R)): M(W') > 863 GeV for purely left-handed couplings, M(W') > 885 GeV for purely right-handed couplings, and M(W') > 916 GeV if both left-and right-handed couplings are present. The limit for right-handed couplings improves for M(W') < m(nu(R)) to M(W') > 890 GeV.
|
|
| 37. |
|
|
| 38. |
- Abel, I, et al.
(författare)
-
Overview of the JET results with the ITER-like wall
- 2013
-
Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
-
Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
|
|
| 39. |
- Abreu, P, et al.
(författare)
-
A measurement of alpha(s) from the scaling violation in e(+)e(-) annihilation
- 1997
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 398:1-2, s. 194-206
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The hadronic fragmentation functions of the various quark flavours and of gluons are measured in a study of the inclusive hadron production from Z(0) decays with the DELPHI detector and are compared with the fragmentation functions measured elsewhere at e
|
|
| 40. |
- Abreu, P, et al.
(författare)
-
A search for eta '(c) production in photon-photon fusion at LEP
- 1998
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 441:1-4, s. 479-490
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A search for the production of the eta(c)' meson, the first radial excitation of the ground state of charmonium eta(c)(2980), in the photon-photon fusion reaction at LEP has been performed using the data collected by the DELPHI detector during 1992-1996.
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
|
|
| 44. |
- Abreu, P, et al.
(författare)
-
Identified particles in quark and gluon jets
- 1997
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 401:1-2, s. 118-130
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A sample of about 1.4 million hadronic Z decays, selected among the data recorded by the DELPHI detector at LEP during 1994, was used to measure for the first time the momentum spectra of K+, K-0, p, Lambda and their antiparticles in gluon and quark jets.
|
|
| 45. |
- ABREU, P, et al.
(författare)
-
J/PSI-PRODUCTION IN THE HADRONIC DECAYS OF THE Z
- 1994
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. ; 341:1, s. 109-122
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- J/psi mesons have been reconstructed from their decay to mu(+)mu(-) and e(+)e(-), using the data collected by the DELPHI experiment during 1991 and 1992 at the LEP collider. From about 1 million hadronic Z decays 153 +/- 17 J/psi were found, 5.4 +/- 2.3 p
|
|
| 46. |
- Abreu, P, et al.
(författare)
-
Measurement of correlations between pions from different W's in e(+)e(-)->W+W- events
- 1997
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 401:1-2, s. 181-191
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Correlations between pions from different W's in e(+)e(-) --> W+W- events are studied using data collected by the DELPHI detector at LEP running at a centre-of-mass energy of 172 GeV in 1996. At the present level of statistics, no enhancement of the corre
|
|
| 47. |
|
|
| 48. |
|
|
| 49. |
- Abreu, P, et al.
(författare)
-
Measurement of the multiplicity of gluons splitting to bottom quark pairs in hadronic Z(0) decays
- 1997
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 405:1-2, s. 202-214
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- An inclusive measurement of the average multiplicity of b (b) over bar pairs from gluons, g(b (b) over bar), in hadronic Z(0) events collected by the DELPHI experiment at LEP, is presented. A counting technique, based on jet b-tagging in 4-jet events, has
|
|
| 50. |
- Abreu, P, et al.
(författare)
-
Measurement of vertical bar V-cs vertical bar using W decays at LEP2
- 1998
-
Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 439:1-2, s. 209-224
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Decays of W+/- bosons, produced at LEP2, have been used to measure the \V-cs\ element of the Cabibbo-Kobayashi-Maskawa matrix. Values for \V-cs\ were extracted both from the measured hadronic branching ratio of W+/- decays and by tagging the flavour of ha
|
|
