| 1. |
- Ferreira, MA, et al.
(författare)
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Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1741-
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
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| 2. |
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| 3. |
- Hollestelle, Antoinette, et al.
(författare)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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| 4. |
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| 5. |
- Baldi, R. D., et al.
(författare)
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LeMMINGs - II. The e-MERLIN legacy survey of nearby galaxies. The deepest radio view of the Palomar sample on parsec scale
- 2021
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 500:4, s. 4749-4767
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Tidskriftsartikel (refereegranskat)abstract
- We present the second data release of high-resolution (≤0.2 arcsec) 1.5-GHz radio images of 177 nearby galaxies from the Palomar sample, observed with the e-MERLIN array, as part of the Legacy e-MERLIN Multi-band Imaging of Nearby Galaxies Sample (LeMMINGs) survey. Together with the 103 targets of the first LeMMINGs data release, this represents a complete sample of 280 local active (LINER and Seyfert) and inactive galaxies (H ii galaxies and absorption line galaxies, ALG). This large program is the deepest radio survey of the local Universe, ≳1017.6 W Hz-1, regardless of the host and nuclear type: we detect radio emission ≳0.25 mJy beam-1 for 125/280 galaxies (44.6 per cent) with sizes of typically ≲100 pc. Of those 125, 106 targets show a core which coincides within 1.2 arcsec with the optical nucleus. Although we observed mostly cores, around one third of the detected galaxies features jetted morphologies. The detected radio core luminosities of the sample range between ∼1034 and 1040 erg s-1. LINERs and Seyferts are the most luminous sources, whereas H ii galaxies are the least. LINERs show FR I-like core-brightened radio structures while Seyferts reveal the highest fraction of symmetric morphologies. The majority of H ii galaxies have single radio core or complex extended structures, which probably conceal a nuclear starburst and/or a weak active nucleus (seven of them show clear jets). ALGs, which are typically found in evolved ellipticals, although the least numerous, exhibit on average the most luminous radio structures, similar to LINERs.
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| 6. |
- Baldi, R. D., et al.
(författare)
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LeMMINGs III. The e-MERLIN legacy survey of the Palomar sample: Exploring the origin of nuclear radio emission in active and inactive galaxies through the [O iii] - Radio connection
- 2021
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 508:2, s. 2019-2038
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Tidskriftsartikel (refereegranskat)abstract
- What determines the nuclear radio emission in local galaxies? To address this question, we combine optical [O iii] line emission, robust black hole (BH) mass estimates, and high-resolution e-MERLIN 1.5-GHz data, from the LeMMINGs survey, of a statistically complete sample of 280 nearby optically active (LINER and Seyfert) and inactive [H ii and absorption line galaxies (ALGs)] galaxies. Using [O iii] luminosity (L[O III]) as a proxy for the accretion power, local galaxies follow distinct sequences in the optical-radio planes of BH activity, which suggest different origins of the nuclear radio emission for the optical classes. The 1.5-GHz radio luminosity of their parsec-scale cores (Lcore) is found to scale with BH mass (MBH) and [O iii] luminosity. Below MBH ∼106.5 M⊙, stellar processes from non-jetted H ii galaxies dominate with Lcore ∝ MBH0.61 ± 0.33 and Lcore ∝ L[O III]0.79 ± 0.30. Above MBH ∼106.5 M⊙, accretion-driven processes dominate with Lcore ∝ MBH1.5-1.65 and Lcore ∝ L[O III]0.99-1.31 for active galaxies: radio-quiet/loud LINERs, Seyferts, and jetted H ii galaxies always display (although low) signatures of radio-emitting BH activity, with L1.5 GHz ≳ 1019.8 W Hz-1 and MBH ≳ 107 M⊙, on a broad range of Eddington-scaled accretion rates (m). Radio-quiet and radio-loud LINERs are powered by low-m discs launching sub-relativistic and relativistic jets, respectively. Low-power slow jets and disc/corona winds from moderately high to high-m discs account for the compact and edge-brightened jets of Seyferts, respectively. Jetted H ii galaxies may host weakly active BHs. Fuel-starved BHs and recurrent activity account for ALG properties. In conclusion, specific accretion-ejection states of active BHs determine the radio production and the optical classification of local active galaxies.
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| 7. |
- Engström, A E, et al.
(författare)
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Mechanical circulatory support with the Impella 5.0 device for postcardiotomy cardiogenic shock: a three-center experience
- 2013
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Ingår i: Minerva Cardioangiologica. - : Edizione Minerva Medica. - 0026-4725 .- 1827-1618. ; 61:5, s. 539-546
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Tidskriftsartikel (refereegranskat)abstract
- AIM:Postcardiotomy cardiogenic shock (PCCS) is associated with high mortality rates, despite full conventional treatment. Although the results of treatment with surgically implantable ventricular assist devices have been encouraging, the invasiveness of this treatment limits its applicability. Several less invasive devices have been developed, including the Impella system. The objective of this study was to describe our three-center experience with the Impella 5.0 device in the setting of PCCS.METHODS:From January 2004 through December 2010, a total of 46 patients were diagnosed with treatment-refractory PCCS and treated with the Impella 5.0 percutaneous left ventricular assist device at three european heart centers. Baseline and follow-up characteristics were collected retrospectively and entered into a dedicated database.RESULTS:Within the study cohort of 46 patients, mean logistic and additive EuroSCORES were 24 ± 19 and 10 ± 4. The majority of patients underwent coronary artery bypass grafting (48%) or combined surgery (33%). Half of all patients had been treated with an intra-aortic balloon pump before 5.0-implantation, 1 patient had been treated with an Impella 2.5 device. All patients were on mechanical ventilation and intravenous inotropes. The Kaplan-Meier estimate of overall 30-day survival was 39.5%.CONCLUSION:Thirty-day survival rates for patients with PCCS, refractory to aggressive conventional treatment and treated with the Impella 5.0 device, are comparable to those reported in studies evaluating surgically implantable VADs, whereas the Impella system is much less invasive. Therefore, mechanical circulatory support with the Impella 5.0 device is a suitable treatment modality for patients with severe PCCS.
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| 8. |
- Henkel, C., et al.
(författare)
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Molecular line emission in NGC 4945, imaged with ALMA
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 615
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Tidskriftsartikel (refereegranskat)abstract
- NGC 4945 is one of the nearest (D ≈ 3.8 Mpc; 1 00 ≈ 19 pc) starburst galaxies. To investigate the structure, dynamics, and composition of the dense nuclear gas of this galaxy, ALMA band 3 (λ ≈ 3−4 mm) observations were carried out with ≈2 00 resolution. Three HCN and two HC + isotopologues, CS, C 3 H 2 , SiO, HCO, and CH 3 C 2 H were measured. Spectral line imaging demonstrates the presence of a rotating nuclear disk of projected size 10 00 × 2 00 reaching out to a galactocentric radius of r ≈ 100 pc with position angle PA = 45 ◦ ± 2 ◦ , inclination i = 75 ◦ ± 2 ◦ and an unresolved bright central core of size <∼ 2 00 . The continuum source, representing mostly free-free radiation from star forming regions, is more compact than the nuclear disk by a linear factor of two but shows the same position angle and is centered 0 00 . 39 ± 0 00 . 14 northeast of the nuclear accretion disk defined by H 2 O maser emission. Near the systemic velocity but outside the nuclear disk, both HCN J = 1 → 0 and CS J = 2 → 1 delineate molecular arms of length >∼ 15 00 ( >∼ 285 pc) on opposite sides of the dynamical center. These are connected by a (deprojected) ≈ 0.6 kpc sized molecular bridge, likely a dense gaseous bar seen almost ends-on, shifting gas from the front and back side into the nuclear disk. Modeling this nuclear disk located farther inside (r <∼ 100 pc) with tilted rings provides a good fit by inferring a coplanar outflow reaching a characteristic deprojected velocity of ≈50 km s −1 . All our molecular lines, with the notable exception of CH 3 C 2 H, show significant absorption near the systemic velocity (≈571 km s −1 ), within the range ≈500-660 km s −1 . Apparently, only molecular transitions with low critical H 2 density (n crit<∼ 10 4 cm −3 ) do not show absorption. The velocity field of the nuclear disk, derived from CH 3 C 2 H, provides evidence for rigid rotation in the inner few arcseconds and a dynamical mass of M tot = (2.1 ± 0.2) × 10 8 M inside a galactocentric radius of 2 00 . 45 (≈45 pc), with a significantly flattened rotation curve farther out. Velocity integrated line intensity maps with most pronounced absorption show molecular peak positions up to ≈1 00 . 5 (≈30 pc) southwest of the continuum peak, presumably due to absorption, which appears to be most severe slightly northeast of the nuclear maser disk. A nitrogen isotope ratio of 14 N/ 15 N ≈ 200-450 is estimated. This range of values is much higher then previously reported on a tentative basis. Therefore, because 15 N is less abundant than expected, the question for strong 15 N enrichment by massive star ejecta in starbursts still remains to be settled.
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| 9. |
- Baan, Willem A., et al.
(författare)
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Dense gas in luminous infrared galaxies
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 477:3, s. 747-U73
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Molecules that trace the high-density regions of the interstellar medium have been observed in (ultra-) luminous (far-) infrared galaxies, in order to initiate multiple-molecule multiple-transition studies to evaluate the physical and chemical environment of the nuclear medium and its response to the ongoing nuclear activity.Methods. The HCN(1-0), HNC(1-0), HCO+ (1-0), CN(1-0) and CN(2-1), CO(2-1), and CS(3-2) transitions were observed in sources covering three decades of infrared luminosity including sources with known OH megamaser activity. The data for the molecules that trace the high-density regions were augmented with data available in the literature.Results. The integrated emissions of high-density tracer molecules show a strong relation to the far-infrared luminosity. Ratios of integrated line luminosities were used for a first-order diagnosis of the integrated molecular environment of the evolving nuclear starbursts. Diagnostic diagrams display significant differentiation among the sources that relate to the initial conditions and the radiative excitation environment. Initial differentiation was introduced between the FUV radiation field in photon-dominated-regions and the X-ray field in X-ray-dominated-regions. The galaxies displaying OH megamaser activity have line ratios typical of photon-dominated regions.
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| 10. |
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| 11. |
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| 12. |
- Loenen, A. F., et al.
(författare)
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Extragalactic Chemistry: HCN, HNC, and HCO+ : M. , W. A. Baan, and R.
- 2008
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Ingår i: EAS Publications Series. - : EAS, EDP Sciences. - 1633-4760 .- 1638-1963. ; 31, s. 183-185
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Tidskriftsartikel (refereegranskat)abstract
- High- and low-density tracer molecules have been observed in (Ultra-) Luminous Infrared Galaxies in order to initiate multi-molecule multi-transition studies to evaluate the physical and chemical environment of the nuclear medium and the ongoing nuclear activity. The data, augmented with data available in the literature, are presented in Baan et al. (2007), which also presents a first order analysis. Here, we present the chemical analysis of the J=1–0 transition lines of HCN, HNC, and HCO+.
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| 13. |
- Loenen, A. F., et al.
(författare)
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Mechanical feedback in the molecular ISM of luminous IR galaxies
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 488:1, s. L5-L8
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Molecular emission lines originating in the nuclei of luminous infra-red galaxies are used to determine the physical properties of the nuclear ISM in these systems.Methods. A large observational database of molecular emission lines is compared with model predictions that include heating by UV and X-ray radiation, mechanical heating, and the effects of cosmic rays.Results. The observed line ratios and model predictions imply a separation of the observed systems into three groups: XDRs, UV-dominated high-density ( $n \geq 10^5$ cm-3) PDRs, and lower-density ( n = 104.5 cm-3) PDRs that are dominated by mechanical feedback.Conclusions. The division of the two types of PDRs follows naturally from the evolution of the star formation cycle of these sources, which evolves from deeply embedded young stars, resulting in high-density ( $n \geq 10^5$ cm-3) PDRs, to a stage where the gas density has decreased ( n = 104.5 cm-3) and mechanical feedback from supernova shocks dominates the heating budget.
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| 14. |
- Lucatelli, Geferson, et al.
(författare)
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The PARADIGM project I: a multiscale radio morphological analysis of local U/LIRGS
- 2024
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Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 529:4, s. 4468-4499
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Tidskriftsartikel (refereegranskat)abstract
- Disentangling the radio flux contribution from star formation (SF) and active-galactic-nuclei (AGNs) activity is a long-standing problem in extragalactic astronomy, since at frequencies of 10 GHz, both processes emit synchrotron radiation. We present in this work the general objectives of the PARADIGM (PAnchromatic high-Resolution Analysis of DIstant Galaxy Mergers) project, a multi-instrument concept to explore SF and mass assembly of galaxies. We introduce two novel general approaches for a detailed multiscale study of the radio emission in local (ultra) luminous infrared galaxies (U/LIRGs). In this work, we use archival interferometric data from the Very Large Array (VLA) centred at ∼6 GHz (C band) and present new observations from the e-Multi-Element Radio-Linked Interferometer Network (e-MERLIN) for UGC 5101, VV 705, VV 250, and UGC 8696. Using our image decomposition methods, we robustly disentangle the radio emission into distinct components by combining information from the two interferometric arrays. We use e-MERLIN as a probe of the core-compact radio emission (AGN or starburst) at ∼20 pc scales, and as a probe of nuclear diffuse emission, at scales ∼100-200 pc. With VLA, we characterize the source morphology and the flux density on scales from ∼200 pc up to and above 1 kpc. As a result, we find deconvolved and convolved sizes for nuclear regions from ∼10 to ∼200 pc. At larger scales, we find sizes of 1.5-2 kpc for diffuse structures (with effective sizes of ∼300-400 pc). We demonstrate that the radio emission from nuclear extended structures (∼100 pc) can dominate over core-compact components, providing a significant fraction of the total multiscale SF output. We establish a multiscale radio tracer for SF by combining information from different instruments. Consequently, this work sets a starting point to potentially correct for overestimations of AGN fractions and underestimates of SF activity.
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| 15. |
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| 16. |
- Baan, Willem A., et al.
(författare)
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Dense Molecular Gas in Luminous Infrared Galaxies: Diagnosing the ISM
- 2008
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Ingår i: EAS Publications Series. - : EAS, EDP Sciences. - 1633-4760 .- 1638-1963. ; 31, s. 111-114
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Tidskriftsartikel (refereegranskat)abstract
- The behavior of molecular tracers of the high-density star-forming ISM provides a diagnostics tool for luminous FIR galaxies. All molecules react differently to the physical and chemical environment and their collective behavior is indicative of the excitation of the ISM and its evolutionary state. This paper describes efforts to diagnose the nuclear medium through multiple-molecule studies.
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| 17. |
- Baan, Willem, et al.
(författare)
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Multimolecular studies of Galactic star-forming regions
- 2014
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 445:4, s. 3331-3344
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Tidskriftsartikel (refereegranskat)abstract
- Molecular emission-line observations of isolated Galactic star-forming regions are used to model the physical properties of the molecular interstellar medium in these systems. Observed line ratios are compared with the results predicted by models that incorporate gas-phase chemistry and the heating by stellar radiation and non-radiative feedback processes. The line ratios of characteristic tracer molecules may be interpreted using the contributions of two distinct components: a cold (40-50 K) and high-density (105-105.5 cm(-3)) photon-dominated region (PDR) with a nominal UV flux density and a warm (similar to 300 K) mechanical heating-dominated region (MHDR) with a slightly lower density (10(4.5)-10(5) cm(-3)). The relative contributions of these structural components are used to model the observed line ratios. Ionized species may be better modelled by adopting an increase of the cosmic ray flux towards the Galactic Centre and the sulphur abundance should depleted by a factor of 200-400 relative to solar values. The line ratios of the Galactic sample are found to be very similar to those of the integrated signature of prominent (ultra) luminous IR Galaxies. The PDRs and MHDRs in the isolated Galactic regions may be modelled with slightly higher mean densities than in extragalactic systems and a higher MHDR temperature resulting from non-radiative mechanical heating. Multimolecular studies are effective in determining the physical and chemical properties of star formation regions by using characteristic line ratios to diagnose their environment. The addition of more molecular species will reduce the existing modelling redundancy.
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| 18. |
- Hagmar, Lars, et al.
(författare)
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Epidemiological evaluation of cytogenetic biomarkers as potential surrogate end-points for cancer.
- 2004
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Ingår i: Mechanisms of Carcinogenesis (IARC Sci. Publ. ; 157). - 9283221575 - 9789283221579 ; :157, s. 207-215
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Various occupational exposures have been monitored by chromosomal aberrations, sister chromatid exchanges and micronuclei in peripheral blood lymphocytes. During the last decade, epidemiological studies have evaluated whether any of these markers foreshadows cancer risk. Results from Nordic, Italian and Czech cohorts support an approximately twofold cancer risk among subjects with high frequencies of chromosomal aberrations, but no such association was seen for any of the other biomarkers. The estimated attributable proportion of high frequencies of chromosomal aberrations for overall cancer risk is 0.25, which gives a quantitative estimate of the chromosomal aberration assay as a surrogate endpoint of cancer. The results from the different cohort studies are contradictory in terms of whether or not the predictive value of the chromosomal aberration assay for cancer is differential with respect to occupational exposure to clastogens. Genetic susceptibility factors are known to affect the frequency of chromosomal aberrations in peripheral blood lymphocytes. It is quite possible that such factors might also affect the frequency of chromosomal aberrations directly or might modify the impact of exposures to clastogen. There is no other biomarker for general cancer risk that is applicable to healthy subjects from the general population with such a high attributable proportion. However, at present only a simplified and tentative model can be proposed for the role of the chromosomal aberration marker in the pathogenesis of cancer.
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| 19. |
- Kari, OK, et al.
(författare)
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Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System
- 2020
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Ingår i: Pharmaceutics. - : MDPI AG. - 1999-4923. ; 12:8
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Tidskriftsartikel (refereegranskat)abstract
- Light-activated liposomes permit site and time-specific drug delivery to ocular and systemic targets. We combined a light activation technology based on indocyanine green with a hyaluronic acid (HA) coating by synthesizing HA–lipid conjugates. HA is an endogenous vitreal polysaccharide and a potential targeting moiety to cluster of differentiation 44 (CD44)-expressing cells. Light-activated drug release from 100 nm HA-coated liposomes was functional in buffer, plasma, and vitreous samples. The HA-coating improved stability in plasma compared to polyethylene glycol (PEG)-coated liposomes. Liposomal protein coronas on HA- and PEG-coated liposomes after dynamic exposure to undiluted human plasma and porcine vitreous samples were hydrophilic and negatively charged, thicker in plasma (~5 nm hard, ~10 nm soft coronas) than in vitreous (~2 nm hard, ~3 nm soft coronas) samples. Their compositions were dependent on liposome formulation and surface charge in plasma but not in vitreous samples. Compared to the PEG coating, the HA-coated liposomes bound more proteins in vitreous samples and enriched proteins related to collagen interactions, possibly explaining their slightly reduced vitreal mobility. The properties of the most abundant proteins did not correlate with liposome size or charge, but included proteins with surfactant and immune system functions in plasma and vitreous samples. The HA-coated light-activated liposomes are a functional and promising alternative for intravenous and ocular drug delivery.
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| 20. |
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| 21. |
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| 22. |
- Wang, Ailing, et al.
(författare)
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Mildly relativistic motion in the radio-quiet quasar PG 1351+640
- 2023
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Ingår i: Monthly Notices of the Royal Astronomical Society: Letters. - 1745-3925 .- 1745-3933. ; 523:1, s. L30-L34
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Tidskriftsartikel (refereegranskat)abstract
- Measuring the proper motion of the emission component in radio-quiet quasars (RQQs) could help to distinguish between the origins of the radio emission and to understand whether the jet production mechanism is the same in radio-loud quasars and RQQs. PG 1351+640 is one of the few RQQs suitable for proper motion studies: it has two compact components on milli-arcsec scales, a flat-spectrum core and a steep-spectrum jet; both components are ≳2 mJy at 5 GHz and are well suited for Very Long Baseline Array (VLBA) observations. We compare recent VLBA observations with that made seventeen years ago and find no significant change in the core-jet separation between 2005 and 2015 (a proper motion of 0.003 mas yr-1). However, the core-jet separation increased significantly between 2015 and 2022, inferring a jet proper motion velocity of 0.063 mas yr-1, which corresponds to an apparent transverse velocity of. The result suggests that the jet of the RQQ PG 1351+640 is mildly relativistic and oriented at a relatively small viewing angle.
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| 23. |
- Wang, Ailing, et al.
(författare)
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VLBI observations of a sample of Palomar-Green quasars - I. Parsec-scale morphology
- 2023
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 518:1, s. 39-53
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Tidskriftsartikel (refereegranskat)abstract
- We observed 20 Palomar-Green quasars at low redshi ft (z < 0.5) with total flux density >1 mJy, including four radio-loud quasars (RLQs) and 16 radio-quiet quasars (RQQs), using the Very Long Baseline Array (VLBA) at 5 GHz. 10 RQQs are clearly detected in the VLBA images, and a compact radio core is identified in eight of them, indicating the prevalence of active galactic nucleus (AGN)-related radio emission in this flux-density-limited RQQ sample. The RQQs and RLQs in our sample have a division at similar to 30 mJy. The radio emission from RQQs appears to be the result of a combination of star formation and AGN-associated activities. All RQQs in our sample have a 5 GHz flux density ratio of Very Large Array (VLA) A-array to D-array f(c) = S-A(VLA)/S-D(VLA) above 0.2. The RQQs with f(a)(VLBA and VLA flux density ratio S-VLBA/S-A(VLA)) > 0.2 versus f(a) < 0.2 show significant differences in morphology, compactness, and total flux density. f(a) of RQQs is systematically lower than that of RLQs, probably due to the extended jets or relic jets of RQQs on tens to hundreds parsecs that are resolved out in VLBA images. Future larger samples, especially with the addition of milliarcsec resolution radio images of RQQs with total flux densities below 1 mJy, can test the conclusions of this paper and contribute to the understanding of the radio emission mechanism of RQQs, and the dichotomy and physical connection between RQQs and RLQs.
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| 24. |
- Yang, Jun, 1979, et al.
(författare)
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A radio structure resolved at the deca-parsec scale in the radio-quiet quasar PDS 456 with an extremely powerful X-ray outflow
- 2019
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 482:2, s. 1701-1705
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Tidskriftsartikel (refereegranskat)abstract
- Active galactic nuclei (AGNs) accreting at rates close to the Eddington limit can host radiatively driven mildly relativistic outflows. Some of these X-ray absorbing but powerful outflows can produce strong shocks, resulting in a significant non-thermal emission. This outflow-driven radio emission might be detectable in the radio-quiet quasar PDS 456, as it has a bolometric luminosity that reaches the Eddington limit and a relativistic wide-aperture X-ray outflow with a kinetic power high enough to quench the star formation in its host galaxy. To investigate this possibility, we performed very-long-baseline interferometric (VLBI) observations of the quasar with the European VLBI Network (EVN) at 5 GHz. The full-resolution EVN image reveals two faint and diffuse radio components with a projected separation of about 20 pc and an average brightness temperature of around two million Kelvin. In relation to the optical submas-accuracy position measured by the Gaia mission, the two components are very likely on opposite sides of an undetected radio core. Thus, the VLBI structure at the deca-pc scale could be either a young jet or a bidirectional radio-emitting outflow, launched in the vicinity of a strongly accreting central engine. Two diffuse components at the hecto-pc scale, likely the relic radio emission from past AGN activity, are tentatively detected on each side in the low-resolution EVN image.
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| 25. |
- Yang, Jun, 1979, et al.
(författare)
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The nearby extreme accretion and feedback system PDS 456: finding a complex radio-emitting nucleus
- 2021
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 500:2, s. 2620-2626
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Tidskriftsartikel (refereegranskat)abstract
- When a black hole accretes close to the Eddington limit, the astrophysical jet is often accompanied by radiatively driven, wide-aperture and mildly relativistic winds. Powerful winds can produce significant non-thermal radio emission via shocks. Among the nearby critical accretion quasars, PDS 456 has a very massive black hole (about 1 billion solar masses), shows a significant star-forming activity (about 70 solar masses per year), and hosts exceptionally energetic X-ray winds (power up to 20 per cent of the Eddington luminosity). To probe the radio activity in this extreme accretion and feedback system, we performed very long baseline interferometric (VLBI) observations of PDS 456 at 1.66 GHz with the European VLBI Network and the enhanced Multi-Element Remotely Linked Interferometry Network. We find a rarely seen complex radio-emitting nucleus consisting of a collimated jet and an extended non-thermal radio emission region. The diffuse emission region has a size of about 360 pc and a radio luminosity about three times higher than that of the nearby extreme starburst galaxy Arp 220. The powerful nuclear radio activity could result either from a relic jet with a peculiar geometry (nearly along the line of sight) or more likely from diffuse shocks formed naturally by the existing high-speed winds impacting on high-density star-forming regions.
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| 26. |
- Yang, Xiaolong, et al.
(författare)
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Radio Activity of Supermassive Black Holes with Extremely High Accretion Rates
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 904:2
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Tidskriftsartikel (refereegranskat)abstract
- Radio emission from the high- A nd super-Eddington accreting active galactic nuclei (AGNs) has various origins: A persistent jet, the magnetized corona, and the wind-like outflows. It is still unclear which is the leading mechanism responsible for the observed radio emission and how the radio emission is related to other characteristic parameters such as the Eddington ratio and black hole mass. In this paper, we present the 5 GHz Very Large Array (VLA) observational results of a sample of 25 extremely high Eddington accreting supermassive black holes (EESBHs, the Eddington ratio λ Edd close to or above 1) in narrow-line Seyfert 1 galaxies, among which 22 sources are detected. Most of the EESBHs show a compact radio structure from a few hundred parsecs to 1 kpc scale. We estimated the lowest star formation rate surface density required for producing the observed radio emission and found that it is higher than the largest value previously detected in circumnuclear starburst galaxies, implying that the radio emission is from the AGN activity. Along with a comparison sample, we find an overall inverse-λ Edd correlation ranging from sub-to super-Eddington ratios. The high-Eddington and mildly super-Eddington AGNs (-0.5 < log) have a radio-to-X-ray luminosity ratio L R/L X ∼ 10-5-10-4 and a steep radio spectrum, supporting that the radio emission is from transient ejecta (outflows) of corona; however, the jet contribution cannot be entirely ruled out. Our highly super-Eddington sources (log) have a flatter radio spectrum, along with its low radio luminosity: ; their radio emission is likely dominated by a magnetized corona, and a radiation-pressure-caused jet is also proposed in this paper.
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| 27. |
- Yang, Xiaolong, et al.
(författare)
-
Unveiling the Small-scale Jets in the Rapidly Growing Supermassive Black Hole IZw1
- 2024
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 966:2
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Tidskriftsartikel (refereegranskat)abstract
- Accretion of black holes at near-Eddington or super-Eddington rates represents the most powerful episode driving black hole growth, potentially occurring across various types of objects. However, the physics governing accretion and jet-disk coupling in such states remains unclear, primarily due to the difficulty in detecting associated jets, which may emit extremely weakly or exhibit episodic behavior. Only a few near/super-Eddington systems have demonstrated radio activity, and it remains uncertain whether jets exist and what their properties are in super-Eddington active galactic nuclei (AGNs) and ultraluminous X-ray sources. This uncertainty stems mainly from the complex radio emission mix, which includes contributions from jets, star formation activity, photoionized gas, accretion disk wind, and coronal activity. In this work, we conducted high-resolution, very long baseline interferometry observations to investigate jets in the highly accreting narrow-line Seyfert I system I Zw 1. Our observations successfully revealed small-scale jets (with a linear size of ∼45 pc) at both 1.5 and 5 GHz, based on the high radio brightness temperature, radio morphology, and spectral index distribution. Additionally, the parsec-scale jet observed in I Zw 1 displays a knotted morphology reminiscent of other sources accreting at similar rates. In summary, the high accretion rates and jet properties observed in the AGN I Zw 1 may support the AGN/X-ray binary analogy in this extreme state.
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