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Sökning: WFRF:(Balazs Csaba)

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1.
  • Bencsik, Gábor, et al. (författare)
  • Electrocatalytic properties of the polypyrrole/magnetite hybrid modified electrode towards the reduction of hydrogen peroxide in the presence of dissolved oxygen
  • 2012
  • Ingår i: Electrochimica Acta. - : Elsevier. - 0013-4686 .- 1873-3859. ; 73, s. 53-58
  • Tidskriftsartikel (refereegranskat)abstract
    • In this study, we report on the electrocatalytic behaviour of a polypyrrole/magnetite hybrid electrode towards the reduction of hydrogen peroxide. The electrocatalytic activity of the composite electrode was demonstrated by cyclic voltammetric and chrono-amperometric measurements in comparison with the identically prepared neat polymer film. The stationary reduction currents, measured at an appropriately chosen potential (here at E = -0.3 V), plotted against the peroxide concentration gave a perfect linear correlation in nitrogen atmosphere in the micromolar concentration range. The performance of the composite electrode was not affected by the presence of sulphate, nitrate or chloride anions. In the presence of dissolved oxygen a complex electrocatalytic activity was observed, involving the reduction of both oxygen and H2O2. However, a linear dependence was found also in oxygen containing media, although with much higher currents, but with the same slope (even at different oxygen concentrations). This fact may trigger the development of such hybrid electrodes towards hydrogen peroxide sensors in different aqueous (including natural) samples.
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2.
  • Biurrun, Idoia, et al. (författare)
  • Benchmarking plant diversity of Palaearctic grasslands and other open habitats
  • 2021
  • Ingår i: Journal of Vegetation Science. - Oxford : John Wiley & Sons. - 1100-9233 .- 1654-1103. ; 32:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Journal of Vegetation Science published by John Wiley & Sons Ltd on behalf of International Association for Vegetation Science.Aims: Understanding fine-grain diversity patterns across large spatial extents is fundamental for macroecological research and biodiversity conservation. Using the GrassPlot database, we provide benchmarks of fine-grain richness values of Palaearctic open habitats for vascular plants, bryophytes, lichens and complete vegetation (i.e., the sum of the former three groups). Location: Palaearctic biogeographic realm. Methods: We used 126,524 plots of eight standard grain sizes from the GrassPlot database: 0.0001, 0.001, 0.01, 0.1, 1, 10, 100 and 1,000 m2 and calculated the mean richness and standard deviations, as well as maximum, minimum, median, and first and third quartiles for each combination of grain size, taxonomic group, biome, region, vegetation type and phytosociological class. Results: Patterns of plant diversity in vegetation types and biomes differ across grain sizes and taxonomic groups. Overall, secondary (mostly semi-natural) grasslands and natural grasslands are the richest vegetation type. The open-access file ”GrassPlot Diversity Benchmarks” and the web tool “GrassPlot Diversity Explorer” are now available online (https://edgg.org/databases/GrasslandDiversityExplorer) and provide more insights into species richness patterns in the Palaearctic open habitats. Conclusions: The GrassPlot Diversity Benchmarks provide high-quality data on species richness in open habitat types across the Palaearctic. These benchmark data can be used in vegetation ecology, macroecology, biodiversity conservation and data quality checking. While the amount of data in the underlying GrassPlot database and their spatial coverage are smaller than in other extensive vegetation-plot databases, species recordings in GrassPlot are on average more complete, making it a valuable complementary data source in macroecology. © 2021 The Authors.
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3.
  • Endrődi, Balázs, 1987-, et al. (författare)
  • Challenges and rewards of the electrosynthesis of macroscopic aligned carbon nanotube array/conducting polymer hybrid assemblies
  • 2015
  • Ingår i: Journal of Polymer Science Part B. - : Wiley. - 0887-6266 .- 1099-0488. ; 53, s. 1507-1518
  • Tidskriftsartikel (refereegranskat)abstract
    • Hybrid assemblies based on conducting polymers and carbon nanomaterials with organized nanoscale structure are excellent candidates for various application schemes ranging from thermal management to electrochemical energy conversion and storage. In the case of macroscopic samples, however, precise control of the nanoscale structure has remained a major challenge to be solved for the scientific community. In this study we demonstrate possible routes to homogeneously infiltrate poly(3-hexylthiophene), poly(3,4-ethylenedioxythiophene), and polyaniline into macroscopic arrays of vertically aligned multiwalled carbon nanotubes (MWCNTAs). Electron microscopic images and Raman spectroscopic analysis (performed along the longitudinal dimension of the hybrid samples) both confirmed that optimization of the electropolymerization circumstances allowed fine tuning of the hybrid structure towards the targeted application. In this vein, three different application avenues were tested. The remarkable anisotropy in both the electrical and thermal conductivity of the nanocomposites makes them eminently attractive candidates to be deployed in thermal management. Thermoelectric studies, aimed to understand the effect of organized nanoscale morphology on the important parameters (Seebeck coefficient, electrical-, and thermal conductivity) compared to their non-organized hybrid counterparts. Finally, extraordinary high charge storage capacity values were registered for the MWCNTA/PANI hybrids (500 F g−1 and 1–3 F cm−2). 
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4.
  • Abahazi, Emese, et al. (författare)
  • Covalently immobilized Trp60Cys mutant of omega‰-transaminase from Chromobacterium violaceum for kinetic resolution of racemic amines in batch and continuous-flow modes
  • 2018
  • Ingår i: Biochemical engineering journal. - : Elsevier. - 1369-703X .- 1873-295X. ; 132, s. 270-278
  • Tidskriftsartikel (refereegranskat)abstract
    • Covalent immobilization of an engineered omega-transaminase mutant Trp60Cys from Chromobacterium violaceum (CvTAW60C) was performed on bisepoxide-activated aminoalkyl resins. Activity of the various CvTAW60C preparations was evaluated in kinetic resolution of four racemic amines (rac-1a–d). The most active EA-G-CvTAW60C preparation (CvTAW60C attached to polymeric resin with ethylamine function activated with glycerol diglycidyl ether—EA-G) could perform the kinetic resolution of racemic 4-phenylbutan-2-amine (rac-1a) over 49% conversion up to 19 consecutive reaction cycles or in media containing up to 50% v/v DMSO as cosolvent in batch mode reactions. The immobilization process of CvTAW60C onto the EA-G resin filled in stainless steel bioreactors was also tested in flow-through mode. Kinetic resolution of three racemic amines containing aromatic moieties (rac-1a-c) was performed in continuous-flow mode resulting in easy-to-separate mixture of the corresponding ketone (2a–c) and the non-converted (R)-amine in high enantiopurity (ee(R)-1a-c ≥ 96%).
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5.
  • Allanach, Benjamin C., et al. (författare)
  • Simple and statistically sound strategies for analysing physical theories
  • 2022
  • Ingår i: Reports on progress in physics (Print). - : Institute of Physics Publishing (IOPP). - 0034-4885 .- 1361-6633. ; 85:5
  • Forskningsöversikt (refereegranskat)abstract
    • Physical theories that depend on many parameters or are tested against data from many different experiments pose unique challenges to statistical inference. Many models in particle physics, astrophysics and cosmology fall into one or both of these categories. These issues are often sidestepped with statistically unsound ad hoc methods, involving intersection of parameter intervals estimated by multiple experiments, and random or grid sampling of model parameters. Whilst these methods are easy to apply, they exhibit pathologies even in low-dimensional parameter spaces, and quickly become problematic to use and interpret in higher dimensions. In this article we give clear guidance for going beyond these procedures, suggesting where possible simple methods for performing statistically sound inference, and recommendations of readily-available software tools and standards that can assist in doing so. Our aim is to provide any physicists lacking comprehensive statistical training with recommendations for reaching correct scientific conclusions, with only a modest increase in analysis burden. Our examples can be reproduced with the code publicly available at Zenodo.
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6.
  • Athron, Peter, et al. (författare)
  • A global fit of the MSSM with GAMBIT
  • 2017
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:12
  • Tidskriftsartikel (refereegranskat)abstract
    • We study the seven-dimensional Minimal Super-symmetric Standard Model (MSSM7) with the new GAMBIT software framework, with all parameters defined at the weak scale. Our analysis significantly extends previous weak-scale, phenomenological MSSM fits, by adding more and newer experimental analyses, improving the accuracy and detail of theoretical predictions, including dominant uncertainties from the Standard Model, the Galactic dark matter halo and the quark content of the nucleon, and employing novel and highly-efficient statistical sampling methods to scan the parameter space. We find regions of the MSSM7 that exhibit co-annihilation of neutralinos with charginos, stops and sbottoms, as well as models that undergo resonant annihilation via both light and heavy Higgs funnels. We find high-likelihood models with light charginos, stops and sbottoms that have the potential to be within the future reach of the LHC. Large parts of our preferred parameter regions will also be accessible to the next generation of direct and indirect dark matter searches, making prospects for discovery in the near future rather good.
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7.
  • Athron, Peter, et al. (författare)
  • Bayesian analysis and naturalness of (Next-to-)Minimal Supersymmetric Models
  • 2017
  • Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :10
  • Tidskriftsartikel (refereegranskat)abstract
    • The Higgs boson discovery stirred interest in next-to-minimal supersymmetric models, due to the apparent fine-tuning required to accommodate it in minimal theories. To assess their naturalness, we compare fine-tuning in a Z(3) conserving semi-constrained Next-to-Minimal Supersymmetric Standard Model (NMSSM) to the constrained MSSM (CMSSM). We contrast popular fine-tuning measures with naturalness priors, which automatically appear in statistical measures of the plausibility that a given model reproduces the weak scale. Our comparison shows that naturalness priors provide valuable insight into the hierarchy problem and rigorously ground naturalness in Bayesian statistics. For the CMSSM and semi-constrained NMSSM we demonstrate qualitative agreement between naturalness priors and popular fine tuning measures. Thus, we give a clear plausibility argument that favours relatively light superpartners.
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8.
  • Athron, Peter, et al. (författare)
  • GAMBIT : the global and modular beyond-the-standard-model inference tool
  • 2017
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
  • Tidskriftsartikel (refereegranskat)abstract
    • We describe the open-source global fitting package GAMBIT: the Global And Modular Beyond-the-Standard-Model Inference Tool. GAMBIT combines extensive calculations of observables and likelihoods in particle and astroparticle physics with a hierarchical model database, advanced tools for automatically building analyses of essentially any model, a flexible and powerful system for interfacing to external codes, a suite of different statistical methods and parameter scanning algorithms, and a host of other utilities designed to make scans faster, safer and more easily-extendible than in the past. Here we give a detailed description of the framework, its design and motivation, and the current models and other specific components presently implemented in GAMBIT. Accompanying papers deal with individual modules and present flrst GAMBIT results. GAMBIT can be downloaded from gambit.hepforge.org.
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9.
  • Athron, Peter, et al. (författare)
  • GAMBIT : the global and modular beyond-the-standard-model inference tool
  • 2018
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:2
  • Tidskriftsartikel (refereegranskat)abstract
    • In Ref. (GAMBIT Collaboration: Athron et. al., Eur. Phys. J. C. arXiv: 1705.07908, 2017) we introduced the global-fitting framework GAMBIT. In this addendum, we describe a new minor version increment of this package. GAMBIT 1.1 includes full support for Mathematica backends, which we describe in some detail here. As an example, we backend SUSYHD (Vega and Villadoro, JHEP 07: 159, 2015), which calculates the mass of the Higgs boson in the MSSM from effective field theory. We also describe updated likelihoods in PrecisionBit and DarkBit, and updated decay data included in DecayBit.
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10.
  • Athron, Peter, et al. (författare)
  • Global analyses of Higgs portal singlet dark matter models using GAMBIT
  • 2019
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present global analyses of effective Higgs portal dark matter models in the frequentist and Bayesian statistical frameworks. Complementing earlier studies of the scalar Higgs portal, we use GAMBIT to determine the preferred mass and coupling ranges for models with vector, Majorana and Dirac fermion dark matter. We also assess the relative plausibility of all four models using Bayesian model comparison. Our analysis includes up-to-date likelihood functions for the dark matter relic density, invisible Higgs decays, and direct and indirect searches for weakly-interacting dark matter including the latest XENON1T data. We also account for important uncertainties arising from the local density and velocity distribution of dark matter, nuclear matrix elements relevant to direct detection, and Standard Model masses and couplings. In all Higgs portal models, we find parameter regions that can explain all of dark matter and give a good fit to all data. The case of vector dark matter requires the most tuning and is therefore slightly disfavoured from a Bayesian point of view. In the case of fermionic dark matter, we find a strong preference for including a CP-violating phase that allows suppression of constraints from direct detection experiments, with odds in favour of CP violation of the order of 100:1. Finally, we present DDCalc2.0.0, a tool for calculating direct detection observables and likelihoods for arbitrary non-relativistic effective operators.
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11.
  • Athron, Peter, et al. (författare)
  • Global fits of GUT-scale SUSY models with GAMBIT
  • 2017
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:12
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the most comprehensive global fits to date of three supersymmetric models motivated by grand unification: the Constrained Minimal Supersymmetric Standard Model (CMSSM), and its Non-Universal Higgs Mass generalisations NUHM1 and NUHM2. We include likelihoods from a number of direct and indirect dark matter searches, a large collection of electroweak precision and flavour observables, direct searches for supersymmetry at LEP and Runs I and II of the LHC, and constraints from Higgs observables. Our analysis improves on existing results not only in terms of the number of included observables, but also in the level of detail with which we treat them, our sampling techniques for scanning the parameter space, and our treatment of nuisance parameters. We show that stau co-annihilation is now ruled out in the CMSSM at more than 95% confidence. Stop co-annihilation turns out to be one of the most promising mechanisms for achieving an appropriate relic density of darkmatter in all threemodels, whilst avoiding all other constraints. We find high-likelihood regions of parameter space featuring light stops and charginos, making them potentially detectable in the near future at the LHC. We also show that tonne-scale direct detection will play a largely complementary role, probing large parts of the remaining viable parameter space, including essentially all models with multi-TeV neutralinos.
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12.
  • Athron, Peter, et al. (författare)
  • SpecBit, DecayBit and PrecisionBit : GAMBIT modules for computing mass spectra, particle decay rates and precision observables
  • 2018
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the GAMBIT modules SpecBit, DecayBit and PrecisionBit. Together they provide a new framework for linking publicly available spectrum generators, decay codes and other precision observable calculations in a physically and statistically consistent manner. This allows users to automatically run various combinations of existing codes as if they are a single package. The modular design allows software packages fulfilling the same role to be exchanged freely at runtime, with the results presented in a common format that can easily be passed to downstream dark matter, collider and flavour codes. These modules constitute an essential part of the broader GAMBIT framework, a major new software package for performing global fits. In this paper we present the observable calculations, data, and likelihood functions implemented in the three modules, as well as the conventions and assumptions used in interfacing them with external codes. We also present 3-BIT-HIT, a command-line utility for computing mass spectra, couplings, decays and precision observables in the MSSM, which shows how the three modules can easily be used independently of GAMBIT.
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13.
  • Athron, Peter, et al. (författare)
  • Status of the scalar singlet dark matter model
  • 2017
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:8
  • Tidskriftsartikel (refereegranskat)abstract
    • One of the simplest viable models for dark matter is an additional neutral scalar, stabilised by a symmetry. Using the GAMBIT package and combining results from four independent samplers, we present Bayesian and frequentist global fits of this model. We vary the singlet mass and coupling along with 13 nuisance parameters, including nuclear uncertainties relevant for direct detection, the local dark matter density, and selected quark masses and couplings. We include the dark matter relic density measured by Planck, direct searches with LUX, PandaX, SuperCDMS and XENON100, limits on invisible Higgs decays from the Large Hadron Collider, searches for high-energy neutrinos from dark matter annihilation in the Sun with IceCube, and searches for gamma rays from annihilation in dwarf galaxies with the Fermi-LAT. Viable solutions remain at couplings of order unity, for singlet masses between the Higgs mass and about 300 GeV, and at masses above 1 TeV. Only in the latter case can the scalar singlet constitute all of dark matter. Frequentist analysis shows that the low-mass resonance region, where the singlet is about half the mass of the Higgs, can also account for all of dark matter, and remains viable. However, Bayesian considerations show this region to be rather fine-tuned.
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14.
  • Balázs, Csaba, et al. (författare)
  • ColliderBit : a GAMBIT module for the calculation of high-energy collider observables and likelihoods
  • 2017
  • Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
  • Tidskriftsartikel (refereegranskat)abstract
    • We describe ColliderBit, a new code for the calculation of high energy collider observables in theories of physics beyond the Standard Model (BSM). ColliderBit features a generic interface to BSM models, a unique parallelised Monte Carlo event generation scheme suitable for large-scale supercomputer applications, and a number of LHC analyses, covering a reasonable range of the BSM signatures currently sought by ATLAS and CMS. ColliderBit also calculates likelihoods for Higgs sector observables, and LEP searches for BSM particles. These features are provided by a combination of new code unique to ColliderBit, and interfaces to existing state-of-the-art public codes. ColliderBit is both an important part of the GAMBIT framework for BSM inference, and a standalone tool for efficiently applying collider constraints to theories of new physics.
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15.
  • Balázs, Csaba, et al. (författare)
  • Cosmological constraints on decaying axion-like particles : a global analysis
  • 2022
  • Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :12
  • Tidskriftsartikel (refereegranskat)abstract
    • Axion-like particles (ALPs) decaying into photons are known to affect a wide range of astrophysical and cosmological observables. In this study we focus on ALPs with masses in the keV–MeV range and lifetimes between 104 and 1013 seconds, corresponding to decays between the end of Big Bang Nucleosynthesis and the formation of the Cosmic Microwave Background (CMB). Using the CosmoBit module of the global fitting framework GAMBIT, we combine state-of-the-art calculations of the irreducible ALP freeze-in abundance, primordial element abundances (including photodisintegration through ALP decays), CMB spectral distortions and anisotropies, and constraints from supernovae and stellar cooling. This approach makes it possible for the first time to perform a global analysis of the ALP parameter space while varying the parameters of ΛCDM as well as several nuisance parameters. We find a lower bound on the ALP mass of around ma > 300 keV, which can only be evaded if ALPs are stable on cosmological timescales. Future observations of CMB spectral distortions with a PIXIE-like mission are expected to improve this bound by two orders of magnitude.
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16.
  • Balazs, Csaba, et al. (författare)
  • Interpreting the Fermi-LAT gamma ray excess in the simplified framework
  • 2015
  • Ingår i: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 92:12
  • Tidskriftsartikel (refereegranskat)abstract
    • We test the plausibility of the hypothesis that the annihilation of a Majorana fermion dark matter particle via a scalar mediator explains the gamma ray excess from the Galactic center. Assuming that the mediator couples to all third generation fermions we calculate observables for dark matter abundance and scattering on nuclei, gamma, positron, and antiproton cosmic ray fluxes, radio emission from dark matter annihilation, and the effect of dark matter annihilations on the CMB. After discarding the controversial radio observation, we show that the dark matter model simultaneously fits the observed excesses in the cosmic gamma ray, the positron, and antiproton fluxes, while evading constraints from the CMB and direct detection. The experimental data are consistent with a dark matter (mediator) mass in the 10-100 (3-1000) GeV region and with weakly correlated couplings to bottom quarks and tau leptons with values of 10(-3) - 1 at the 68% credibility level.
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17.
  • Balázs, Csaba, et al. (författare)
  • Sensitivity of the Cherenkov Telescope Array to the detection of a dark matter signal in comparison to direct detection and collider experiments
  • 2017
  • Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Imaging atmospheric Cherenkov telescopes (IACTs) that are sensitive to potential.-ray signals from dark matter (DM) annihilation above similar to 50 GeV will soon be superseded by the Cherenkov Telescope Array (CTA). CTA will have a point source sensitivity an order of magnitude better than currently operating IACTs and will cover a broad energy range between 20 GeV and 300 TeV. Using effective field theory and simplified models to calculate gamma-ray spectra resulting from DM annihilation, we compare the prospects to constrain such models with CTA observations of the Galactic center with current and near-future measurements at the Large Hadron Collider (LHC) and direct detection experiments. For DM annihilations via vector or pseudoscalar couplings, CTA observations will be able to probe DM models out of reach of the LHC, and, if DM is coupled to standard fermions by a pseudoscalar particle, beyond the limits of current direct detection experiments.
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18.
  • Balint, Monika, et al. (författare)
  • Binding Networks Identify Targetable Protein Pockets for Mechanism-Based Drug Design
  • 2022
  • Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:13
  • Tidskriftsartikel (refereegranskat)abstract
    • The human genome codes only a few thousand druggable proteins, mainly receptors and enzymes. While this pool of available drug targets is limited, there is an untapped potential for discovering new drug-binding mechanisms and modes. For example, enzymes with long binding cavities offer numerous prerequisite binding sites that may be visited by an inhibitor during migration from a bulk solution to the destination site. Drug design can use these prerequisite sites as new structural targets. However, identifying these ephemeral sites is challenging. Here, we introduce a new method called NetBinder for the systematic identification and classification of prerequisite binding sites at atomic resolution. NetBinder is based on atomistic simulations of the full inhibitor binding process and provides a networking framework on which to select the most important binding modes and uncover the entire binding mechanism, including previously undiscovered events. NetBinder was validated by a study of the binding mechanism of blebbistatin (a potent inhibitor) to myosin 2 (a promising target for cancer chemotherapy). Myosin 2 is a good test enzyme because, like other potential targets, it has a long internal binding cavity that provides blebbistatin with numerous potential prerequisite binding sites. The mechanism proposed by NetBinder of myosin 2 structural changes during blebbistatin binding shows excellent agreement with experimentally determined binding sites and structural changes. While NetBinder was tested on myosin 2, it may easily be adopted to other proteins with long internal cavities, such as G-protein-coupled receptors or ion channels, the most popular current drug targets. NetBinder provides a new paradigm for drug design by a network-based elucidation of binding mechanisms at an atomic resolution.
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19.
  • Bloor, Sanjay, et al. (författare)
  • The GAMBIT Universal Model Machine : from Lagrangians to likelihoods
  • 2021
  • Ingår i: European Physical Journal C. - : Springer Nature. - 1434-6044 .- 1434-6052. ; 81:12
  • Tidskriftsartikel (refereegranskat)abstract
    • We introduce the GAMBIT Universal Model Machine (GUM), a tool for automatically generating code for the global fitting software framework GAMBIT, based on Lagrangian-level inputs. GUM accepts models written symbolically in FeynRules and SARAH formats, and can use either tool along with MadG rap h and CaIcHEP to generate GAMBIT model, collider, dark matter, decay and spectrum code, as well as GAMBIT interfaces to corresponding versions of SPheno, micrOMEGAs, Pythia and Vevacious (C++). In this paper we describe the features, methods, usage, pathways, assumptions and current limitations of GUM. We also give a fully worked example, consisting of the addition of a Majorana fermion simplified dark matter model with a scalar mediator to GAMBIT via GUM, and carry out a corresponding fit.
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20.
  • Brasko, Csilla, et al. (författare)
  • Intelligent image-based in situ single-cell isolation
  • 2018
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Quantifying heterogeneities within cell populations is important for many fields including cancer research and neurobiology; however, techniques to isolate individual cells are limited. Here, we describe a high-throughput, non-disruptive, and cost-effective isolation method that is capable of capturing individually targeted cells using widely available techniques. Using high-resolution microscopy, laser microcapture microscopy, image analysis, and machine learning, our technology enables scalable molecular genetic analysis of single cells, targetable by morphology or location within the sample.
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21.
  • Dengler, Juergen, et al. (författare)
  • GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands
  • 2018
  • Ingår i: Phytocoenologia. - : Schweizerbart. - 0340-269X. ; 48:3, s. 331-347
  • Tidskriftsartikel (refereegranskat)abstract
    • GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.
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22.
  • Endrodi, Balazs, et al. (författare)
  • One-Step Electrodeposition of Nanocrystalline TiO2 Films with Enhanced Photoelectrochemical Performance and Charge Storage
  • 2018
  • Ingår i: ACS Applied Energy Materials. - : American Chemical Society (ACS). - 2574-0962. ; 1:2, s. 851-858
  • Tidskriftsartikel (refereegranskat)abstract
    • With the rapid development of renewable energy technologies there is an urgent need to find synthesis routes that address the needs of materials in a reproducible and affordable way. In this study, we present a one-step electrochemical method for the deposition of nanocrystalline titanium dioxide films on different carbon substrates. By optimizing the synthetic conditions, electrodeposition of nanocrystalline and porous titanium dioxide layers was achieved in only a few minutes. To deconvolute the complex effect of the solution pH and temperature, as well as the deposition potential, a set of systematic experiments was carried out on glassy carbon electrodes. The robustness and general applicability of this synthetic approach is demonstrated by extending it to graphene film electrodes. The phase composition of TiO2 was controlled by varying the solution composition. The photoelectrochemical performance of the electrodeposited titanium dioxide films was better than, or at least comparable to the benchmark P25 titanium dioxide films. Hydrogen-ion intercalation measurements for the TiO2/graphene electrodes indicated promising charge storage capacity, which might be exploited in the future in Li-ion batteries.
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23.
  • Idoia Biurrun, Idoia, et al. (författare)
  • GrassPlot v. 2.00 – first update on the database of multi-scale plant diversity in Palaearctic grasslands
  • 2019
  • Ingår i: Palaearctic Grasslands. - : Eurasian Dry Grassland Group (EDGG). - 2627-9827. ; :44, s. 26-47
  • Tidskriftsartikel (refereegranskat)abstract
    • GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). Following a previous Long Database Report (Dengler et al. 2018, Phytocoenologia 48, 331–347), we provide here the first update on content and functionality of GrassPlot. The current version (GrassPlot v. 2.00) contains a total of 190,673 plots of different grain sizes across 28,171 independent plots, with 4,654 nested-plot series including at least four grain sizes. The database has improved its content as well as its functionality, including addition and harmonization of header data (land use, information on nestedness, structure and ecology) and preparation of species composition data. Currently, GrassPlot data are intensively used for broad-scale analyses of different aspects of alpha and beta diversity in grassland ecosystems.
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24.
  • Juhasz, Balazs, et al. (författare)
  • Peripheral quantitative computed tomography in the assessment of bone mineral density in anti-TNF-treated rheumatoid arthritis and ankylosing spondylitis patients
  • 2021
  • Ingår i: BMC Musculoskeletal Disorders. - : BioMed Central (BMC). - 1471-2474. ; 22:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are associated with osteoporosis. There have not been many peripheral quantitative computed tomography (QCT) studies in patients receiving biologics. We assessed volumetric and areal bone mineral density (BMD) by forearm QCT and dual-energy X-ray absorptiometry (DXA), respectively in addition to laboratory biomarkers in these arthritides. Methods Forty RA and AS patients treated with either etanercept (ETN) or certolizumab pegol (CZP) were undergoing follow-ups for one year. Volumetric and areal BMD, as well as parathyroid hormone (PTH), osteocalcin, RANKL, 25-hydroxyvitamin D (VITD), P1NP, CTX, sclerostin (SOST), Dickkopf 1 (DKK-1) and cathepsin K (CATHK) were determined. Results We did not observe any further bone loss during the 12-month treatment period. Volumetric and areal BMD showed significant correlations with each other (p<0.017 after Bonferroni's correction). Trabecular QCT BMD at baseline (p=0.015) and cortical QCT BMD after 12 months (p=0.005) were inversely determined by disease activity at baseline in the full cohort. Trabecular QCT BMD at baseline also correlated with CTX (p=0.011). In RA, CRP negatively (p=0.014), while SOST positively (p=0.013) correlated with different QCT parameters. In AS, RANKL at baseline (p=0.014) and after 12 months (p=0.007) correlated with cortical QCT BMD. In the full cohort, 12-month change in QTRABBMD was related to TNF inhibition together with elevated VITD-0 levels (p=0.031). Treatment and lower CATHK correlated with QCORTBMD changes (p=0.006). In RA, TNF inhibition together with VITD-0 (p<0.01) or CATHK-0 (p=0.002), while in AS, treatment and RANKL-0 (p<0.05) determined one-year changes in QCT BMD. Conclusions BMD as determined by QCT did not change over one year of anti-TNF treatment. Disease activity, CATHK, RANKL and VITD may be associated with the effects of anti-TNF treatment on QCT BMD changes. RA and AS may differ in this respect.
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25.
  • Kalmár, Péter János, et al. (författare)
  • A MECHANIKUS THROMBECTOMIÁT MEGELÔZÔ INTRAVÉNÁS THROMBOLYSIS SZEREPE AZ AKUT AGYI NAGYÉRELZÁRÓDÁSOK KEZELÉSÉBEN : [The role of intravenous thrombolysis before mechanical thrombectomy in the treatment of large vessel occlusion strokes]
  • 2022
  • Ingår i: Ideggyógyászati szemle. - : Literatura Medica Kiado. - 0019-1442 .- 2498-6208. ; 75:1-2, s. 23-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and purpose: The efficacy of intravenous thrombolysis (IVT) is moderate in the proximal vascular segments of intracranial arteries, as opposed to mecha-nical thrombectomy (MT). In the management of acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), IVT prior to MT is highly recommended based on the latest guidelines, but the necessity of IVT has been questioned by the latest studies of the past years. The aim of our study was to investigate and compare the efficacy and safety of direct mechanical thrombectomy (dMT) and combined therapy (CT) for patients who suffered an AIS with LVO and were treated in our department.Methods: We investigated patients with AIS caused by LVO who were admitted up to 4.5 hours after symptom onset and underwent MT in our department between November 2017 and August 2019. Patients' data were collected in our stroke register. Patients enrolled in our study were divided into two groups depending on whether dMT or CT was used. Our primary outcome was the 30- and 90- day functional outcome measured by modified Rankin Scale (mRS). Mortality at 30- and 90- day, successful recanalization rates, and symptomatic intracranial hemorrhage were considered as secondary outcomes.Results: A total of 142 patients (age: 68.3 ± 12.6 years, 53.5% female) were enrolled in our study, including 81 (57.0%) dMT cases, and 61 (43.0%) patients who received CT. The vascular risk factors and comorbidities were significantly higher in the dMT-treated group. At day 30, the rate of favorable functional outcomes was 34.7% in dMT vs. 43.6% among those who received CT (p = 0.307), by day 90 this ratio changed to 40.8% vs. 46.3% (p = 0.542). Mortality rates at day 30 were 22.2% and 23.6% (p = 0.851), and at day 90 33.8% and 25.9% (p = 0.343). The rate of effective recanalization was 94.2% for dMT-treated patients and 98.0% for CT-treated patients (p = 0.318). Symptomatic intracranial hemorrhage was detected in 2.5% of dMT-treated patients and 3.4% of CT-treated group (p = 0.757).Conclusion: Our results suggest that CT is associated with a moderately better outcome compared to dMT. IVT prior to MT did not increase the risk of symptomatic intracranial hemorrhages.
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26.
  • Kalmar, Peter Janos, et al. (författare)
  • Comparing endovascular treatment methods in acute ischemic stroke Due to tandem occlusion focusing on clinical aspects
  • 2021
  • Ingår i: Life. - : MDPI. - 2075-1729. ; 11:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Acute ischemic strokes (AIS) due to tandem occlusion (TO) of intracranial anterior large vessel and concomitant extracranial internal carotid artery (EICA) are represent in 15-20% of all ischemic strokes. The endovascular treatment (EVT) strategy for those patients is still unclear. Although the intracranial mechanical thrombectomy (MT) is considered as a standard treatment approach, the EICA lesion stent necessity remains a matter of debate. We sought to assess the efficacy and safety of EVT in tandem lesions, particularly the EICA stenting management.Methods: We retrospectively analyzed all patients with anterior circulation stroke associated with EICA lesion and receiving EVT in the three participated stroke centers between November 2017 and December 2020. Patients' data were collected from our prospective stroke registry (STAY ALIVE). Patients enrolled in our study were divided into two groups depending on whether acute carotid stenting (ACS) or balloon angioplasty only (BAO) technique was used. Our primary outcome was the 90-day functional outcome assessed by modified Rankin scale (mRS). Mortality at 90 days and symptomatic intracranial hemorrhage (sICH) were considered as secondary outcomes.Results: A total of 101 patients (age: 67 ± 10 years, 38.6% female) were enrolled in our study, including 29 (28.3%) BAO cases, and 72 (71.3%) patients treated with ACS. Patients in the BAO group were slightly older (70 ± 9 years vs. 66 ± 10 years, p = 0.054), and had higher prevalence of comorbidities such as hypertension (100.0% vs. 59.4%, p < 0.001). There was no significant difference in favorable outcomes (51.7% vs. 54.4%, p = 0.808) between the groups. However, we observed a trend towards higher rates of sICH (8.3% vs. 3.4%, p = 0.382) and 90-day mortality (23.5% vs. 13.8%, p = 0.278) with significantly higher frequency of distal embolization (39.1% vs. 17.9%, p = 0.043) in patients with ACS. In the overall population age (p = 0.013), atrial fibrillation (AF) (p = 0.008), National Institutes of Health Stroke Scale (NIHSS) baseline (p = 0.029), and successful recanalization (p = 0.023) were associated with favorable outcome.Conclusion: Endovascular approach of EICA in addition to MT was safe and effective in tandem occlusion of anterior circulation. Furthermore, our results suggest that balloon angioplasty technique without acute stenting shows a comparable favorable outcome rate to ACS with moderately less hemorrhagic events and mortality rates.
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27.
  • Maróti, Zoltán, et al. (författare)
  • The genetic origin of Huns, Avars, and conquering Hungarians
  • 2022
  • Ingår i: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 32:13, s. 2858-2870, 2858–2870.e1–e7
  • Tidskriftsartikel (refereegranskat)abstract
    • Huns, Avars, and conquering Hungarians were migration-period nomadic tribal confederations that arrived in three successive waves in the Carpathian Basin between the 5th and 9th centuries. Based on the historical data, each of these groups are thought to have arrived from Asia, although their exact origin and relation to other ancient and modern populations have been debated. Recently, hundreds of ancient genomes were analyzed from Central Asia, Mongolia, and China, from which we aimed to identify putative source populations for the above-mentioned groups. In this study, we have sequenced 9 Hun, 143 Avar, and 113 Hungarian conquest period samples and identified three core populations, representing immigrants from each period with no recent European ancestry. Our results reveal that this “immigrant core” of both Huns and Avars likely originated in present day Mongolia, and their origin can be traced back to Xiongnus (Asian Huns), as suggested by several historians. On the other hand, the “immigrant core” of the conquering Hungarians derived from an earlier admixture of Mansis, early Sarmatians, and descendants of late Xiongnus. We have also shown that a common “proto-Ugric” gene pool appeared in the Bronze Age from the admixture of Mezhovskaya and Nganasan people, supporting genetic and linguistic data. In addition, we detected shared Hun-related ancestry in numerous Avar and Hungarian conquest period genetic outliers, indicating a genetic link between these successive nomadic groups. Aside from the immigrant core groups, we identified that the majority of the individuals from each period were local residents harboring “native European” ancestry.
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28.
  • Renk, Janina J., et al. (författare)
  • CosmoBit : a GAMBIT module for computing cosmological observables and likelihoods
  • 2021
  • Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :2
  • Tidskriftsartikel (refereegranskat)abstract
    • We introduce CosmoBit, a module within the open-source GAMBIT software framework for exploring connections between cosmology and particle physics with joint global fits. CosmoBit provides a flexible framework for studying various scenarios beyond ACDM, such as models of inflation, modifications of the effective number of relativistic degrees of freedom, exotic energy injection from annihilating or decaying dark matter, and variations of the properties of elementary particles such as neutrino masses and the lifetime of the neutron. Many observables and likelihoods in CosmoBit are computed via interfaces to AlterBBN, CLASS, DarkAges, MontePython, MultiModeCode, and plc. This makes it possible to apply a wide range of constraints from large-scale structure, Type Ia supernovae, Big Bang Nucleosynthesis and the cosmic microwave background. Parameter scans can be performed using the many different statistical sampling algorithms available within the GAMBIT framework, and results can be combined with calculations from other GAMBIT modules focused on particle physics and dark matter. We include extensive validation plots and a first application to scenarios with non-standard relativistic degrees of freedom and neutrino temperature, showing that the corresponding constraint on the sum of neutrino masses is much weaker than in the standard scenario.
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29.
  • Székely, Anna J., et al. (författare)
  • DGGE and T-RFLP analysis of bacterial succession during mushroom compost production and sequence-aided T-RFLP profile of mature compost
  • 2009
  • Ingår i: Microbial Ecology. - : Springer Science and Business Media LLC. - 0095-3628 .- 1432-184X. ; 57:3, s. 522-533
  • Tidskriftsartikel (refereegranskat)abstract
    • The amount of button mushroom (Agaricus bisporus) harvested from compost is largely affected by the microbial processes taking place during composting and the microbes inhabiting the mature compost. In this study, the microbial changes during the stages of this specific composting process were monitored, and the dominant bacteria of the mature compost were identified to reveal the microbiological background of the favorable properties of the heat-treated phase II mushroom compost. 16S ribosomal deoxyribonucleic acid (rDNA)-based denaturing gradient gel electrophoresis (DGGE) and terminal restriction fragment length polymorphism (T-RFLP) molecular fingerprinting methods were used to track the succession of microbial communities in summer and winter composting cycles. DNA from individual DGGE bands were reamplified and subjected to sequence analysis. Principal component analysis of fingerprints of the composting processes showed intensive changes in bacterial community during the 22-day procedure. Peak temperature samples grouped together and were dominated by Thermus thermophilus. Mature compost patterns were almost identical by both methods (DGGE, T-RFLP). To get an in-depth analysis of the mature compost bacterial community, the sequence data from cultivation of the bacteria and cloning of environmental 16S rDNA were uniquely coupled with the output of the environmental T-RFLP fingerprints (sequence-aided T-RFLP). This method revealed the dominance of a supposedly cellulose-degrading consortium composed of phylotypes related to Pseudoxanthomonas, Thermobifida, and Thermomonospora. © 2008 Springer Science+Business Media, LLC.
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