| 1. |
- Valiente-Dobon, J. J., et al.
(author)
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Conceptual design of the AGATA 2 pi array at LNL
- 2023
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 1049
-
Journal article (peer-reviewed)abstract
- The Advanced GAmma Tracking Array (AGATA) has been installed at Laboratori Nazionali di Legnaro (LNL), Italy. In this installation, AGATA will consist, at the beginning, of 13 AGATA triple clusters (ATCs) with an angular coverage of 1n,and progressively the number of ATCs will increase up to a 2 pi angular coverage. This setup will exploit both stable and radioactive ion beams delivered by the Tandem-PIAVE-ALPI accelerator complex and the SPES facility. The new implementation of AGATA at LNL will be used in two different configurations, firstly one coupled to the PRISMA large-acceptance magnetic spectrometer and lately a second one at Zero Degrees, along the beam line. These two configurations will allow us to cover a broad physics program, using different reaction mechanisms, such as Coulomb excitation, fusion-evaporation, transfer and fission at energies close to the Coulomb barrier. These setups have been designed to be coupled with a large variety of complementary detectors such as charged particle detectors, neutron detectors, heavy-ion detectors, high-energy gamma-ray arrays, cryogenic and gasjet targets and the plunger device for lifetime measurements. We present in this paper the conceptual design, characteristics and performance figures of this implementation of AGATA at LNL.
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| 2. |
- Polettini, M., et al.
(author)
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Decay studies in the A∼225 Po-Fr region from the DESPEC campaign at GSI in 2021
- 2022
-
In: Il Nuovo Cimento. - : Società Italiana di Fisica. - 2037-4909. ; 45:5
-
Journal article (peer-reviewed)abstract
- The HISPEC-DESPEC collaboration aims at investigating the structure of exotic nuclei formed in fragmentation reactions with decay spectroscopy measurements, as part of the FAIR Phase-0 campaign at GSI. This paper reports on first results of an experiment performed in spring 2021, with a focus on beta-decaystudies in the Po-Fr nuclei in the 220 < A <230 island of octupole deformation exploiting the DESPEC setup. Ion-beta correlations and fast-timing techniques are being employed, giving an insight into this difficult-to-reach region.
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| 3. |
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| 4. |
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| 5. |
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| 6. |
- Ruperto, N., et al.
(author)
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A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis
- 2007
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In: Arthritis Rheum. - : Wiley. - 0004-3591. ; 56:9, s. 3096-3106
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid arthritis (JRA). METHODS: This was an international, multicenter, randomized, placebo-controlled, double-blind study. One hundred twenty-two children with persistent polyarticular JRA despite prior methotrexate (MTX) therapy were randomized to receive infliximab or placebo for 14 weeks, after which all children received infliximab through week 44. Patients received MTX plus infliximab 3 mg/kg through week 44, or MTX plus placebo for 14 weeks followed by MTX plus infliximab 6 mg/kg through week 44. RESULTS: Although a higher proportion of patients in the 3 mg/kg infliximab group than in the placebo group had achieved responses according to the American College of Rheumatology (ACR) Pediatric 30 (Pedi 30) criteria for improvement at week 14 (63.8% and 49.2%, respectively), the between-group difference in this primary efficacy end point was not statistically significant (P = 0.12). By week 16, after the crossover from placebo to infliximab 6 mg/kg when all patients were receiving infliximab, an ACR Pedi 30 response was achieved in 73.2% of all patients. By week 52, ACR Pedi 50 and ACR Pedi 70 responses had been reached in 69.6% and 51.8%, respectively, of patients. Infliximab was generally well tolerated, but the safety profile of infliximab 3 mg/kg appeared less favorable than that of infliximab 6 mg/kg, with more frequent occurrences of serious adverse events, infusion reactions, antibodies to infliximab, and newly induced antinuclear antibodies and antibodies to double-stranded DNA observed with the 3 mg/kg dose. CONCLUSION: While infliximab at 3 mg/kg and 6 mg/kg showed durable efficacy at 1 year, achievement of the primary efficacy end point at 3 months did not differ significantly between infliximab-treated and placebo-treated patients. Safety data indicated that the 6-mg/kg dose may provide a more favorable risk/benefit profile. These results warrant further investigation in children with JRA.
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| 7. |
- Andre, M., et al.
(author)
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Multi-spacecraft observations of broadband waves near the lower hybrid frequency at the Earthward edge of the magnetopause
- 2001
-
In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 19:12-okt, s. 1471-1481
-
Journal article (peer-reviewed)abstract
- Broadband waves around the lower hybrid frequency (around 10 Hz) near the magnetopause are studied, using the four Cluster satellites. These waves are common at the Earthward edge of the boundary layer, consistent with earlier observations, and can have amplitudes at least up to 5 mV/m. These waves are similar on all four Cluster satellites, i.e. they are likely to be distributed over large areas of the boundary. The strongest electric fields occur during a few seconds, i.e. over distances of a few hundred km in the frame of the moving magnetopause, a scale length comparable to the ion gyroradius. The strongest magnetic oscillations in the same frequency range are typically found in the boundary layer, and across the magnetopause. During an event studied in detail, the magnetopause velocity is consistent with a large-scale depression wave, i.e. an inward bulge of magnetosheath plasma, moving tailward along the nominal magnetopause boundary. Preliminary investigations indicate that a rather flat front side of the large-scale wave is associated with a rather static small-scale electric field, while a more turbulent backside of the large-scale wave is associated with small-scale time varying electric field wave packets.
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| 8. |
- Lockwood, M, et al.
(author)
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Coordinated Cluster and ground-based instrument observations of transient changes in the magnetopause boundary layer during an interval of predominantly northward IMF : relation to reconnection pulses and FTE signatures
- 2001
-
In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 19:10-12, s. 1613-1640
-
Research review (peer-reviewed)abstract
- We study a series of transient entries into the low-latitude boundary layer (LLBL) of all four Cluster spacecraft during an outbound pass through the mid-afternoon magnetopause ([X(GSM), Y(GSM), Z(GSM)] approximate to [2, 7, 9] R(E)). The events take place during an interval of northward IMF, as seen in the data from the ACE satellite and lagged by a propagation delay of 75 min that is well-defined by two separate studies: (1) the magnetospheric variations prior to the northward turning (Lockwood et al., 2001, this issue) and (2) the field clock angle seen by Cluster after it had emerged into the magnetosheath (Opgenoorth et al., 2001, this issue). With an additional lag of 16.5 min, the transient LLBL events cor-relate well with swings of the IMF clock angle (in GSM) to near 90degrees. Most of this additional lag is explained by ground-based observations, which reveal signatures of transient reconnection in the pre-noon sector that then take 10-15 min to propagate eastward to 15 MLT, where they are observed by Cluster. The eastward phase speed of these signatures agrees very well with the motion deduced by the cross-correlation of the signatures seen on the four Cluster spacecraft. The evidence that these events are reconnection pulses includes: transient erosion of the noon 630 nm (cusp/cleft) aurora to lower latitudes; transient and travelling enhancements of the flow into the polar cap, imaged by the AMIE technique; and poleward-moving events moving into the polar cap, seen by the EISCAT Svalbard Radar (ESR). A pass of the DMSP-F15 satellite reveals that the open field lines near noon have been opened for some time: the more recently opened field lines were found closer to dusk where the flow transient and the poleward-moving event intersected the satellite pass. The events at Cluster have ion and electron characteristics predicted and observed by Lockwood and Hapgood (1998) for a Flux Transfer Event (FTE), with allowance for magnetospheric ion reflection at Alfvenic disturbances in the magnetopause reconnection layer. Like FTEs, the events are about 1 R(E) in their direction of motion and show a rise in the magnetic field strength, but unlike FTEs, in general, they show no pressure excess in their core and hence, no characteristic bipolar signature in the boundary-normal component. However, most of the events were observed when the magnetic field was southward, i.e. on the edge of the interior magnetic cusp, or when the field was parallel to the magnetic equatorial plane. Only when the satellite begins to emerge from the exterior boundary (when the field was northward), do the events start to show a pressure excess in their core and the consequent bipolar signature. We identify the events as the first observations of FTEs at middle altitudes.
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| 9. |
- Andre, M., Behlke, R., Wahlund, J.E., Vaivads, A., Eriksson, A., Tjulin, A., Carozzi, T. D., Cully, C., Gustafsson, G., Sundkvist, D., Khotyaintsev, Y., Cornilleau-Wehrlin, N., Rezeau, L., Maksimovic, M., Lucek, E., Balogh, A., Dunlop, M., Lindqvist, P.A.
(author)
-
Multi-spacecraft observations of broadband waves near the lower hybrid frequency at the Earthward edge of the magnetopause.
- 2001
-
In: Annales Geophysicae. ; 19:6, s. 1471-1481
-
Journal article (peer-reviewed)abstract
- Broadband waves around the lower hybrid frequency (around 10 Hz) near the magnetopause are studied, using the four Cluster satellites. These waves are common at the Earthward edge of the boundary layer, consistent with earlier observations, and can have a
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| 10. |
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| 11. |
- Pelaz, B, et al.
(author)
-
Diverse Applications of Nanomedicine
- 2017
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In: ACS nano. - : American Chemical Society (ACS). - 1936-086X .- 1936-0851. ; 11:3, s. 2313-2381
-
Journal article (peer-reviewed)
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| 12. |
- Ruperto, N., et al.
(author)
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PRINTO/PRES international website for families of children with rheumatic diseases: www.pediatric-rheumatology.printo.it
- 2005
-
In: Ann Rheum Dis. - : BMJ. - 0003-4967. ; 64:7, s. 1101-6
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: To prepare a website for families and health professionals containing up to date information about paediatric rheumatic diseases (PRD). METHODS: Firstly, paediatric rheumatology centres and family self help associations were surveyed to characterise current clinical practice of physicians providing care for children with PRD, research activities, and training facilities of each centre. Secondly, international consensus was reached on the content of the website. Finally, the website was developed and the texts translated. RESULTS: The web page contains three main sections: (a) description for families of the characteristics of 15 PRD; (b) list of paediatric rheumatology centres; (c) contact information for family self help associations. A version for 45 countries in 52 languages (with another three in progress) is now available on the web. 291 surveys from 171 centres and 102 family associations were received from 42 countries. The median proportion of time spent in paediatric practice in the centres examined was 100%, with 70% of this time dedicated to paediatric rheumatology. 90% of the centres were willing to perform clinical trials in the future. CONCLUSIONS: The PRINTO/PRES website provides a well defined and competent set of information about PRD, with appropriate multiple translated versions and easy web navigational direction.
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| 13. |
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| 14. |
- Gutierrez-Suarez, R., et al.
(author)
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Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas. The PRINTO multinational quality of life cohort study
- 2007
-
In: Rheumatology (Oxford). - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 46:2, s. 314-320
-
Journal article (peer-reviewed)abstract
- OBJECTIVES: To compare health-related quality of life (HRQL) and to identify clinical determinants for poor HRQL of patients with juvenile idiopathic arthritis (JIA) coming from three geographic areas.METHODS: The HRQL was assessed through the Child Health Questionnaire (CHQ). A total of 30 countries were included grouped in three geographic areas: 16 countries in Western Europe; 10 in Eastern Europe; and four in Latin America. Potential determinants of poor HRQL included demographic data, physician's and parent's global assessments, measures of joint inflammation, disability as measured by Childhood Health Assessment Questionnaire (CHAQ) and erythrocyte sedimentation rate. Poor HRQL was defined as a CHQ physical summary score (PhS) or psychosocial summary score (PsS) <2 S.D. from that of healthy children.RESULTS: A total of 3167 patients with JIA, younger than 18 yrs, were included in this study. The most affected health concepts (<2 S.D. from healthy children) that differentiate the three geographic areas include physical functioning, bodily pain/discomfort, global health, general health perception, change in health with respect to the previous year, self-esteem and family cohesion. Determinants for poor HRQL were similar across geographic areas with physical well-being mostly affected by the level of disability while the psychosocial well-being by the intensity of pain.CONCLUSION: We found that patients with JIA have a significant impairment of their HRQL compared with healthy peers, particularly in the physical domain. Disability and pain are the most important determinants of physical and psychosocial well-being irrespective of the geographic area of origin.
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| 15. |
- Kotmayer, L, et al.
(author)
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Landscape of BCL2 Resistance Mutations in a Real-World Cohort of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Treated with Venetoclax
- 2023
-
In: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 24:6
-
Journal article (peer-reviewed)abstract
- The oral, highly selective Bcl2 inhibitor venetoclax has substantially improved the therapeutic landscape of chronic lymphocytic leukemia (CLL). Despite the remarkable response rates in patients with relapsed/refractory (R/R) disease, acquired resistance is the leading cause of treatment failure, with somatic BCL2 mutations being the predominant genetic drivers underpinning venetoclax resistance. To assess the correlation between disease progression and the most common BCL2 mutations G101V and D103Y, sensitive (10−4) screening for the most common BCL2 mutations G101V and D103Y was performed in 67 R/R CLL patients during venetoclax single-agent or venetoclax–rituximab combination therapy. With a median follow-up time of 23 months, BCL2 G101V and D103Y were detected in 10.4% (7/67) and 11.9% (8/67) of the cases, respectively, with four patients harboring both resistance mutations. Ten out of eleven patients carrying BCL2 G101V and/or D103Y experienced relapse during the follow-up period, representing 43.5% of the cases (10/23) showing clinical signs of disease progression. All BCL2 G101V or D103Y variants were detected in patients receiving venetoclax as a continuous single-agent treatment while these mutations were not observed during or after fixed-duration venetoclax therapy. Targeted ultra-deep sequencing of BCL2 uncovered three additional variants in four patient samples obtained at relapse, suggesting convergent evolution and implying a cooperating role of BCL2 mutations in driving venetoclax resistance. This cohort is the largest R/R CLL patient population reported to date in which BCL2 resistance mutations were investigated. Our study demonstrates the feasibility and clinical value of sensitive screening for BCL2 resistance mutations in R/R CLL.
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| 16. |
- Marchaudon, A., et al.
(author)
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Simultaneous double star and cluster ftes observations on the dawnside flank of the magnetosphere
- 2006
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In: Eur Space Agency Spec Publ ESA SP. - 929092909X - 9789290929093 ; , s. 163-170
-
Conference paper (peer-reviewed)abstract
- We present Cluster and Double Star-1 (TC-1) observations from a close magnetic conjunction on May 8, 2004. The five spacecraft were on the dawnside flank of the magnetosphere, with TC-1 located near the equatorial plane and Cluster at higher geographic latitudes in the southern hemisphere. TC-1, at its apogee, skimmed the magnetopause for almost 8 hours (between 08:00-16:00 UT). Flux Transfer Events (FTEs), moving southward/tailward from the reconnection site, were observed by TC-1 throughout almost all of the period. Cluster, travelling on a mainly dawn-dusk trajectory, crossed the magnetopause at around 10:30 UT in the same Magnetic Local Time (MLT) sector as TC-1 and remained close to the magnetopause boundary layer in the southern hemisphere. The four Cluster spacecraft observed FTEs for a period of 6.5 hours between 07:30 and 14:00 UT. From the properties of these FTEs, the reconnection site was located northward of both TC-1 and Cluster on the dawn flank of the magnetosphere. Reconnection occurred between draped magnetosheath and closed magnetospheric field lines. Despite variable interplanetary magnetic field (IMF) conditions and IMF-B z turnings, the IMF clock-angle remained greater than 70° and the location site appeared to remain relatively stable in position during the whole period. This result is in agreement with previous studies which reported that the dayside reconnection remained active for an IMF clock-angle greater than 70°. The simultaneous observation of FTEs at both Cluster and TC-1, separated by 2 hours in MLT, implies that the reconnection site on the magnetopause must have been extended over several hours in MLT. This event has been already presented in more details in [1].
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| 17. |
- Marklund, G.T., Ivchenko, N., Karlsson, T., Fazakerley, A., Dunlop, M., Lindqvist, P.A., Buchert, S., Owen, C., Taylor, M., Vaivalds, A., Carter, P., Andre, M. and Balogh, A.
(author)
-
Temporal evolution of the electric field accelerating electrons away from the auroral ionosphere.
- 2001
-
In: Nature. ; 414:6865, s. 724-727
-
Journal article (peer-reviewed)abstract
- The bright night-time aurorae that are visible to the unaided eye are caused by electrons accelerated towards Earth by an upward-pointing electric field(1-3). On adjacent geomagnetic field lines the reverse process occurs: a downward-pointing electric fie
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| 18. |
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| 19. |
- Nagy, A, et al.
(author)
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Quantitative Analysis and Monitoring of EZH2 Mutations Using Liquid Biopsy in Follicular Lymphoma
- 2020
-
In: Genes. - : MDPI AG. - 2073-4425. ; 11:7
-
Journal article (peer-reviewed)abstract
- Recent advances in molecular technologies enable sensitive and quantitative assessment of circulating tumor DNA, offering a noninvasive disease monitoring tool for patients with malignant disorders. Here, we demonstrated on four follicular lymphoma cases that circulating tumor DNA based EZH2 mutation analysis performed by a highly sensitive droplet digital PCR method may be a valuable treatment monitoring approach in EZH2 mutant follicular lymphoma. EZH2 variant allele frequencies changed in parallel with the volume of metabolically active tumor sites observed on 18F-fluorodeoxyglucose positron emission tomography combined with computer tomography (PET-CT) scans. Variant allele frequencies of EZH2 mutations decreased or were eliminated rapidly upon successful treatment, with treatment failure being associated with elevated EZH2 variant allele frequencies. We also demonstrated spatial heterogeneity in a patient with two different EZH2 mutations in distinct anatomical sites, with both mutations simultaneously detected in the liquid biopsy specimen. In summary, circulating tumor DNA based EZH2 mutation analysis offers a rapid, real-time, radiation-free monitoring tool for sensitive detection of EZH2 mutations deriving from different anatomical sites in follicular lymphoma patients receiving immunochemotherapy.
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| 20. |
- Marklund, Göran T., et al.
(author)
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Temporal evolution of the electric field accelerating electrons away from the auroral ionosphere
- 2001
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 414:6865, s. 724-727
-
Journal article (peer-reviewed)abstract
- The bright night-time aurorae that are visible to the unaided eye are caused by electrons accelerated towards Earth by an upward-pointing electric field(1-3). On adjacent geomagnetic field lines the reverse process occurs: a downward-pointing electric field accelerates electrons away from Earth(4-11). Such magnetic-field-aligned electric fields in the collisionless plasma above the auroral ionosphere have been predicted(12), but how they could be maintained is still a matter for debate(13). The spatial and temporal behaviour of the electric fields-a knowledge of which is crucial to an understanding of their nature-cannot be resolved uniquely by single satellite measurements. Here we report on the first observations by a formation of identically instrumented satellites crossing a beam of upward-accelerated electrons. The structure of the electric potential accelerating the beam grew in magnitude and width for about 200 s, accompanied by a widening of the downward-current sheet, with the total current remaining constant. The 200-s timescale suggests that the evacuation of the electrons from the ionosphere contributes to the formation of the downward-pointing magnetic-field-aligned electric fields. This evolution implies a growing load in the downward leg of the current circuit, which may affect the visible discrete aurorae.
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| 21. |
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| 22. |
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| 23. |
- Picetti, Edoardo, et al.
(author)
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Early management of adult traumatic spinal cord injury in patients with polytrauma : a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)
- 2024
-
In: World Journal of Emergency Surgery. - : BioMed Central (BMC). - 1749-7922. ; 19
-
Journal article (peer-reviewed)abstract
- Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies.Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted.Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak).Conclusions: This consensus provides practical recommendations to support a clinician's decision making in the management of tSCI polytrauma patients.
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| 24. |
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| 25. |
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| 26. |
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| 27. |
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| 28. |
- Wahlund, J.-E., Yilmaz, A., Backrud, M., Sundkvist, D., Vaivads, A., Winningham, D., Andre, M., Balogh, A., Bonnell, J. Buckert, S. and 9 coauthors
(author)
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Observations of auroral broadband emissions by CLUSTER
- 2003
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In: Geophysical Research Letters. - : American Goephysical Union. ; 30:11, s. 17-
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Journal article (peer-reviewed)
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| 29. |
- Arnold, C. L., et al.
(author)
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Energy scaling of gas nonlinear optics
- 2017
-
In: 30th Annual Conference of the IEEE Photonics Society, IPC 2017. - 9781509065783 ; 2017-January, s. 503-504
-
Conference paper (peer-reviewed)abstract
- Nonlinear light-matter interactions, such as filamentation or high-order harmonic generation, are at the heart of nonlinear optics. Scaling of such effects is crucial to benefit optimally from novel laser developments. We introduce and discuss a general scaling model for nonlinear light-matter interactions in gases.
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| 30. |
- Backrud, M., Wahlund, J., Andre, M., Balogh, A., Buckert, S., Cornilleau, N., Vaivads, A.
(author)
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Widespread Eletrostatic ion Cyclotron/ion Acoustic Turbulence Above Auroral Acceleration Region, CLUSTER Observations
- 2003
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In: American Geophysical Union, Fall Meeting 2003.
-
Conference paper (other academic/artistic)
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| 31. |
- Bavassano Cattaneo, M. Bice, et al.
(author)
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Kinetic signatures during a quasi-continuous lobe reconnection event : Cluster Ion Spectrometer (CIS) observations
- 2006
-
In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 111:A9, s. A09212-
-
Journal article (peer-reviewed)abstract
- On 3 December 2001 the Cluster spacecraft observed a long-lasting lobe reconnection event in the southern high-latitude dusk magnetopause (MP) tailward of the cusp, during a 4 hour interval of mainly northward interplanetary magnetic field ( IMF) and of sub-Alfvenic magnetosheath flow. Almost all the MP encounters have accelerated flows ( for which the Walen test has been successfully verified by Retino et al. ( 2005)) as well as a large number of secondary populations related to reconnection, that is, ions of magnetosheath or magnetospheric origin which cross the MP either way. The detailed analysis of the distribution functions shows that the reconnection site frequently moves relative to the spacecraft, but simultaneous measurements by two spacecraft on opposite sides of the reconnection site indicate that the spacecraft's distance from the X line is small, i.e., below 3200 km. The vicinity to the X line throughout the event is probably the reason why the distribution functions characteristics agree with theoretical expectations on both sides of the reconnection site throughout this long event. Moreover, the detailed analysis of the distribution functions shows evidence, during a few time intervals, of dual reconnection, i.e., of reconnection simultaneously going on also in the northern hemisphere.
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| 32. |
- Behlke, Rico, et al.
(author)
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Solitary structures associated with short large-amplitude magnetic structures (SLAMS) upstream of the Earth's quasi-parallel bow shock
- 2004
-
In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 31:16
-
Journal article (peer-reviewed)abstract
- [1] For the first time, solitary waves (SWs) have been observed within short large-amplitude magnetic structures (SLAMS) upstream of the Earth's quasi-parallel bow shock. The SWs often occur as bipolar pulses in the electric field data and move parallel to the background magnetic field at velocities of v = 400–1200 km/s. They have peak-to-peak amplitudes in the parallel electric field of up to E′∥ = 65 mV/m and parallel scale sizes of L∥ ∼ 10 λD. The bipolar solitary waves exhibit negative potential structures of ∣Φ∥∣ = 0.4–2.2 V, i.e., eΦ∥/kTe ∼ 0.1. None of the theories commonly used to describe SWs adequately address these negative potential structures moving at velocities above the ion thermal speed in a weakly magnetized plasma.
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| 33. |
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| 34. |
- Heyl, C. M., et al.
(author)
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High-average power high-harmonic and attosecond sources : Status and prospects
- 2016
-
In: Compact EUV and X-ray Light Sources, EUVXRAY 2016. - 9781943580095 ; Part F14-EUVXRAY 2016
-
Conference paper (peer-reviewed)abstract
- Experiments employing extreme ultraviolet sources based on high harmonic generation often suffer from photon flux limitations. We discuss current status and prospects for scaling such sources to higher repetition rate, pulse energy and average power.
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| 35. |
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| 36. |
- Heyl, C. M., et al.
(author)
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Scale-invariant nonlinear optical effects in gases
- 2016
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In: 2016 Conference on Lasers and Electro-Optics, CLEO 2016. - 9781943580118
-
Conference paper (peer-reviewed)abstract
- A general scaling formalism for nonlinear light-matter interactions in gases is presented and experimentally verified. The formalism enables to conveniently extrapolate nonlinear phenomena, such as filamentation or high-order harmonic generation, to new laser parameters.
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| 37. |
- Heyl, C. M., et al.
(author)
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Scaling Nonlinear Optics in Gases
- 2016
-
In: High Intensity Lasers and High Field Phenomena, HILAS 2016. - 9781943580095 ; Part F15-HILAS 2016
-
Conference paper (peer-reviewed)abstract
- Extrapolating nonlinear phenomena, such as filamentation, to new parameters as e.g. to higher pulse energy is often challenging. We here present a general scaling model for nonlinear light-matter interactions in gases and proof it experimentally.
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| 38. |
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| 39. |
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| 40. |
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| 41. |
- Picetti, Edoardo, et al.
(author)
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Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities : a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES)
- 2023
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In: World Journal of Emergency Surgery. - : BioMed Central (BMC). - 1749-7922. ; 18:1
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Journal article (peer-reviewed)abstract
- BACKGROUND: Severe traumatic brain-injured (TBI) patients should be primarily admitted to a hub trauma center (hospital with neurosurgical capabilities) to allow immediate delivery of appropriate care in a specialized environment. Sometimes, severe TBI patients are admitted to a spoke hospital (hospital without neurosurgical capabilities), and scarce data are available regarding the optimal management of severe isolated TBI patients who do not have immediate access to neurosurgical care.METHODS: A multidisciplinary consensus panel composed of 41 physicians selected for their established clinical and scientific expertise in the acute management of TBI patients with different specializations (anesthesia/intensive care, neurocritical care, acute care surgery, neurosurgery and neuroradiology) was established. The consensus was endorsed by the World Society of Emergency Surgery, and a modified Delphi approach was adopted.RESULTS: A total of 28 statements were proposed and discussed. Consensus was reached on 22 strong recommendations and 3 weak recommendations. In three cases, where consensus was not reached, no recommendation was provided.CONCLUSIONS: This consensus provides practical recommendations to support clinician's decision making in the management of isolated severe TBI patients in centers without neurosurgical capabilities and during transfer to a hub center.
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| 42. |
- Sung, S. -K, et al.
(author)
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Simultaneous ground-based and satellite observations of Pc5 geomagnetic pulsations : A case study using multipoint measurements
- 2006
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In: Earth Planets and Space. - 1343-8832 .- 1880-5981. ; 58:7, s. 873-883
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Journal article (peer-reviewed)abstract
- Pc5 pulsations with a latitude-independent frequency of similar to 2.8 rnHz (period similar to 6 min) were observed with ground-based magnetometers in the morning sector (0700-1000 local time) from 0730 to 0810 UT, April 29, 2001. The pulsations exhibited an amplitude peak and a similar to 180 degrees phase change at similar to 67 degrees geomagnetic latitude. A vortex structure of the equivalent ionospheric current system was also observed centered at the geomagnetic latitude between 67 degrees and 71 degrees. During the Pc5 event, the Polar spacecraft was located near the morningside magnetic equator and crossed magnetic field lines conjugate to the ground stations at which the pulsations were strong. Polar observed similar to 2.8 mHz pulsations in the radial electric field and compressional magnetic field components. Since toroidal mode Alfven waves in the magnetosphere are characterized by an electric field perturbation in the radial direction, the simultaneous presence of pulsations in both components indicates that a field line resonance (FLR) was driven by compressional pulsations. The ground H component at the station conjugate to Polar and the radial electric field perturbation at Polar oscillated with a great similarity without a phase delay. From an analysis of the ground-satellite data, we suggest that the ground perturbations are associated with toroidal mode Alfven waves rather than compressional mode propagating across magnetic field lines. In addition, we discuss the source of the compressional perturbations observed at Polar using solar wind and geosynchronous data.
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| 43. |
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| 44. |
- Yamauchi, M., et al.
(author)
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Magnetospheric solitary structure maintained by 3000 km/s ions as a cause of westward moving auroral bulge at 19 MLT
- 2009
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In: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 27:7, s. 2947-2969
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Journal article (peer-reviewed)abstract
- In the evening equatorial magnetosphere at about 4 R-E geocentric distance and 19 MLT, the four Cluster spacecraft observed a solitary structure with a width of about 1000 similar to 2000 km in the propagation direction. The solitary structure propagates sunward with about 5 similar to 10 km/s carrying sunward electric field (in the propagation direction) of up to about 10 mV/m (total potential drop of about 5 similar to 10 kV), depletion of magnetic field of about 25%, and a duskward E x B convection up to 50 km/s of He+ rich cold plasma without O+. At the same time, auroral images from the IMAGE satellite together with ground based geomagnetic field data showed a westward (sunward at this location) propagating auroral bulge at the magnetically conjugate ionosphere with the solitary structure. The solitary structure is maintained by flux enhancement of selectively 3000 km/s ions (about 50 keV for H+, 200 keV for He+, and 750 keV for O+). These ions are the main carrier of the diamagnetic current causing the magnetic depletion, whereas the polarization is maintained by different behavior of energetic ions and electrons. Corresponding to aurora, field-aligned accelerated ionospheric plasma of several keV appeared at Cluster from both hemispheres simultaneously. Together with good correspondence in location and propagation velocity between the auroral bulge and the solitary structure, this indicates that the sunward moving auroral bulge is caused by the sunward propagation of the solitary structure which is maintained by energetic ions. The solitary structure might also be the cause of Pi2-like magnetic variation that started simultaneously at Cluster location.
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| 45. |
- Yordanova, Emiliya, et al.
(author)
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Turbulence and intermittency in the heliospheric magnetic field in fast and slow solar wind
- 2009
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In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114:8, s. A08101-
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Journal article (peer-reviewed)abstract
- We study the nonuniform solar wind turbulence using high-resolution Ulysses magnetic field data measured at different solar activity level, heliospheric latitudes, and distance. We define several types of solar wind dependent of the coronal region of origin and also of the dynamical behavior of the different streams, namely, "pure'' fast wind, fast streams, "pure'' slow wind, and slow streams. The turbulent properties of the solar wind types were investigated in terms of their scaling properties and spatial inhomogeneity. A clear trend in the power spectrum of the solar wind magnetic field magnitude is observed: the "pure'' fast wind has a slope similar to-1.33 (1/f-like), the fast streams similar to-1.48 (Kraichnan-like), the "pure'' slow wind similar to-1.67 (Kolmogorov-like), and the slow streams similar to-1.72. We find that the "pure'' fast wind in the polar heliolatitudes is less intermittent than the other types: "pure'' slow wind and both slow and fast streams, which is because of the absence of dynamical interactions between streams with different speeds. On the other hand, fast streams are more intermittent than the "pure'' fast wind, and slow streams are less intermittent than the "pure'' slow winds. A clear radial and latitudinal evolution of the intermittency is observed only for the "pure'' fast wind, while in the equatorial plane, the fast streams, the "pure'' slow wind, and the slow streams do not show evolution either in heliolatitude or in heliocentric distance.
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| 46. |
- Adhikarla, V.K., et al.
(author)
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Freehand interaction with large-scale 3D map data
- 2014
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In: 3DTV-Conference. - 2161-2021 .- 2161-203X. - 9781479947584 ; , s. Article number 6874711-
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Conference paper (peer-reviewed)abstract
- In this paper, we present our method and apparatus to visualize and interact with large-scale 3D map data on a 3D light-field display in real time. 3D map data are streamed over Internet to the display in real-time based on request sent by the application. On the user side, data is processed and visualized on a large-scale 3D light field display. We present a method to efficiently interact with the visualized 3D map using freehand gestures. We use a Leap Motion sensor that supports sufficient refresh rate for our current application and is able to accurately track and acquire information on the user hand position. This information is further processed to support natural and fast interaction. We have also developed a method to automatically adjust the map's plane to the screen plane of the display. The visualization and interaction method is scalable and allows the exploration of large-scale 3D maps down to the street level.
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| 47. |
- Arnold, C. L., et al.
(author)
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Stabilized interferometric attosecond timing measurements
- 2013
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In: CLEO : QELS_Fundamental Science, CLEO:QELS FS 2013 - QELS_Fundamental Science, CLEO:QELS FS 2013. - 9781557529725
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Conference paper (peer-reviewed)abstract
- We perform interferometric attosecond timing measurements to study XUV photoionization in noble gases, to diagnose macroscopic phase-matching conditions in high-order harmonic generation, and to investigate single-photon double-ionization by detecting electron pairs in coincidence.
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| 48. |
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| 49. |
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