| 1. |
- Alakangas, Lena, et al.
(författare)
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Norrbottens malm- och mineralresurs och dess potentiella betydelse för innovation, samhälle och miljö
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Gruvindustrins betydelse för samhällsutveckling och infrastruktur i Sverige och inte minst i Norrbottens län är mycket stor. De geologiska förutsättningarna att hitta nya brytvärda förekomster i Norrbotten är goda. Länet är tillsammans med Västerbotten en av Europas viktigaste regioner för utvinning av metaller. Det syns också i den nyligen framtagna regionala mineralstrategin för Norrbotten och Västerbotten. Visionen för den regionala mineralstrategin: ”Genom långsiktigt hållbart nyttjande av Norrbottens och Västerbottens läns mineralresurser har ytterligare tillväxt skapats i regionen och hela Sverige. Vi har utvecklat och stärkt vår ställning som ledande gruv- och mineralnation.”Eftersom framtidspotentialen för gruvnäringen är mycket god men okunnigheten hos både allmänhet och beslutsfattare om näringens betydelse för innovation och samhällsutveckling är stor, kopplat med en utbredd oro för miljöpåverkan, måste dessa viktiga framtidsfrågor belysas. Med finansiering från Länsstyrelsen i Norrbotten bedrevs därför under första hälften av 2014 en förstudie som syftade till att sammanfatta kunskapsläget om framtidens gruvindustri i Norrbotten. Resultaten av förstudien redovisas i den här rapporten. En viktig slutsats är att det under nästa strukturfondsperiod (med start 2015) behövs ett framtidsinriktat forskningsprogram för att belysa de möjligheter som finns. Denna förstudie utgör grund för en kommande ansökan till strukturfonderna. Kompetensen som finns vid Luleå tekniska universitet, Sveriges centrum för gruvrelaterad forskning och utbildning, bör användas för att studera troliga framtidsmöjligheter och hur de ska kunna användas för att få en så positiv utveckling som möjligt för länet. Projektet bör innehålla följande tre huvudinriktningar, som naturligtvis hör ihop:Vilka malm- och mineralresurser finns det potential för i Norrbotten, och vilka kommer sannolikt att exploateras i framtiden?Vad kommer den exploateringen att ha för betydelse för innovation och samhällsutveckling?Vad kommer den exploateringen att få för miljöeffekter och hur ska man göra för att minska miljöbelastningen?En annan slutsats är att nedlagda gruvområden inte måste ses som förstörd natur. Betydande mervärden som gruvturism skulle kunna skapas om vilja, kreativitet och beslutsamhet finns. Detta är ett givet utvecklingsområde där småföretag och entreprenörer kan göra stor insats om de politiska och myndighetsmässiga förutsättningarna finns. Dessa aspekter skulle också kunna belysas i det föreslagna forskningsprogrammet eller i ett eget projekt.
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| 2. |
- Bark, Björn
(författare)
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Aspects of sepsis/SIRS - An experimental study on fluid therapy, vitamin C and plasma volume in increased permeability
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In sepsis, after major surgery or severe trauma, the human body may suffer from various degrees of generalized inflammation, a syndrome called Systemic Inflammatory Response Syndrome (SIRS). One feature of SIRS is increased capillary permeability, caused by disruption of the capillary endothelium due to e.g. bacterial toxins, cytokines, pro-inflammatory hormones and free oxygen radicals. This will result in leakage of plasma fluid to the interstitum with subsequent intravascular hypovolemia and potentially harmful tissue oedema. Restoration of plasma volume with intravenous fluids is a cornerstone in the treatment of SIRS, but the infused fluids would be expected to leak through the capillary membrane to a greater extent, being less effective and further aggravating oedema Thus, an important challenge in patients with increased capillary permeability will therefore be to achieve and maintain normovolemia with as little plasma volume substitution as possible. Also, finding a treatment that could seal the leaking capillaries would be of great value. Study I and II, performed in a sepsis/SIRS animal model, showed that the plasma volume expansion of 5% albumin, 6% HES 130/0.4, 4% gelatin and 6% dextran 70 measured 3 hours after start of infusion was larger when given with a slow infusion rate than when given with a fast infusion rate. This effect was not seen with 0.9% NaCl. In study III, performed in rat models, we compared the initial plasma volume expanding effect of 0.9% NaCl in sepsis/SIRS, after a standardized hemorrhage, and in a normal condition. It showed that the increase in plasma volume in relation to the infused volume of 0.9% NaCl (32 mL/kg) were 0.6% in in sepsis/SIRS, 20% after hemorrhage, and 12% when given to rats in a normal state. This means that efficacy of 0.9% NaCl is highly affected by pathophysiological changes in sepsis/SIRS, e.g. increased capillary permeability. In study IV, two different treatment regimes of high-dose vitamin C, initiated 3 hours after induction of sepsis, were investigated regarding their effect on plasma volume loss. None of the treatment regimes were found to have any effect on the loss of plasma volume, or any of the physiological parameters analysed, in the early stage of severe sepsis/SIRS in the rat.
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| 3. |
- Bark, Björn, et al.
(författare)
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Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin, 6% HES 130/0.4, 4% Gelatin, and 0.9% NaCl in the Septic Rat.
- 2013
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Ingår i: Critical Care Medicine. - 1530-0293. ; 41:3, s. 857-866
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES:: To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these fluids. DESIGN:: Prospective, randomized animal study. SETTING:: University hospital laboratory. SUBJECTS:: One hundred and twelve adult male rats. INTERVENTIONS:: Sepsis was induced by cecal ligation and incision followed by closure of the abdomen. After 3 hrs, an infusion of the PV expander under study was started at a volume of 12 mL/kg for the colloids and of 48 mL/kg for 0.9% NaCl, either for 15 mins or for 3 hrs. A control group underwent the same experimental procedure but no fluid was given. MEASUREMENTS AND MAIN RESULTS:: Three hours after start of the infusion (end of experiment), the plasma-expanding effect was better with a slow than a fast infusion rate for the colloids, especially albumin, but the NaCl groups did not differ significantly from the control group. The PV for the control group was 28.7 ± 3 mL/kg. In the slow and the fast infusion groups, it was 38.9 ± 4.3 and 32.6 ± 4.2 mL/kg for albumin (p < 0.001), 32.9 ± 4.3 and 29.5 ± 4.4 mL/kg for hydroxyethyl starch 130/0.4 (p < 0.05), 31.8 ± 3.9 and 28.2 ± 4.1 mL/kg for gelatin (p < 0.05), and 31.8 ± 5.3 and 30.7 ± 6.6 mL/kg for NaCl (n.s), respectively. CONCLUSIONS:: The study showed that the PV expansion by a colloid was greater when given at a slow than at a fast infusion rate, an effect more pronounced for albumin. This difference was not seen for NaCl. The PV-expanding effect was poor for NaCl and better for albumin than for the other colloids.
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| 4. |
- Bark, Björn, et al.
(författare)
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Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig.
- 2014
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Ingår i: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172. ; 58:1, s. 44-51
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Tidskriftsartikel (refereegranskat)abstract
- Intravenous fluid treatment of hypovolaemia in states of increased capillary permeability, e.g. sepsis, is often accompanied by adverse oedema formation. A challenge is therefore to achieve and maintain normovolaemia using as little plasma volume substitution as possible to minimise interstitial oedema. In the present study, we evaluated the importance of infusion rate for the plasma volume expanding effects of 6% dextran 70 and 5% human albumin in a guinea pig sepsis model.
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| 5. |
- Bark, Björn, et al.
(författare)
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Plasma Volume Expansion by 0.9% NaCl During sepsis/SIRS, After Hemorrhage, and During a Normal State.
- 2013
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Ingår i: Shock. - 1540-0514. ; 40:1, s. 59-64
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To determine the degree of plasma volume expansion by 0.9% NaCl in relation to the infused volume, in sepsis/SIRS (systemic inflammatory response syndrome), after a standardized hemorrhage, and in a normal condition. DESIGN: Prospective, randomized animal study. SETTING: University hospital laboratory. SUBJECTS: Thirty anesthetized adult male rats. INTERVENTIONS: The study was performed in 3 groups: a sepsis/SIRS group (the S group), in which sepsis/SIRS was induced by cecal ligation and incision, a hemorrhage group (the H group), in which the rats were left without intervention for 4 hrs, and bled 8 mL/kg thereafter. The study also included a group that was left without intervention (the N group). Then, 4 hrs after baseline, all 3 groups were given an infusion of 0.9% NaCl (32 mL/kg) for 15 mins. Baseline was defined as the time point when the surgical preparation was finished. MEASUREMENTS AND MAIN RESULTS: Plasma volumes were measured using I-albumin dilution technique at baseline, after 4 hrs, and 20 mins after the end of infusion. The plasma volume-expanding effect 20 mins after end of infusion was 0.6 ± 2.9% in the S group, 20 ± 6.4% in the H group and 12 ± 11% in the N group, compared to just before start of infusion. CONCLUSIONS: The present study in rats showed that the plasma volume-expanding effect after an infusion of 0.9% NaCl was smaller in a septic/SIRS state than after hemorrhage and in a normal state. This indicates that the plasma volume expanding effect of a crystalloid in sepsis/SIRS is dependent on pathophysiological changes.
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| 6. |
- Bark, Björn, et al.
(författare)
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The effect of vitamin C on plasma volume in the early stage of sepsis in the rat.
- 2014
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Ingår i: Intensive Care Medicine Experimental. - 2197-425X. ; 2:11
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Tidskriftsartikel (refereegranskat)abstract
- Previous experimental studies have shown that vitamin C has several beneficial effects in sepsis and burns, such as decreased tissue oedema, improved endothelial barrier function and decreased transcapillary leakage of plasma markers. It has still not been investigated, though, if vitamin C has any impact specifically on plasma volume. The present study aims at testing the hypothesis that vitamin C decreases plasma volume loss in sepsis.
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| 7. |
- Gromada, Jesper, et al.
(författare)
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Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta
- 2005
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 102:29, s. 10303-8
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Tidskriftsartikel (refereegranskat)abstract
- Cytosolic free Ca2+ plays an important role in the molecular mechanisms leading to regulated insulin secretion by the pancreatic beta cell. A number of Ca2+-binding proteins have been implicated in this process. Here, we define the role of the Ca2+-binding protein neuronal Ca2+ sensor-1 (NCS-1) in insulin secretion. In pancreatic beta cells, NCS-1 increases exocytosis by promoting the priming of secretory granules for release and increasing the number of granules residing in the readily releasable pool. The effect of NCS-1 on exocytosis is mediated through an increase in phosphatidylinositol (PI) 4-kinase beta activity and the generation of phosphoinositides, specifically PI 4-phosphate and PI 4,5-bisphosphate. In turn, PI 4,5-bisphosphate controls exocytosis through the Ca2+-dependent activator protein for secretion present in beta cells. Our results provide evidence for an essential role of phosphoinositide synthesis in the regulation of glucose-induced insulin secretion by the pancreatic beta cell. We also demonstrate that NCS-1 and its downstream target, PI 4-kinase beta, are critical players in this process by virtue of their capacity to regulate the release competence of the secretory granules.
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| 8. |
- Han, Kaijia, 1974, et al.
(författare)
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A procedure for optimizing cavitating blades in a given wake
- 2006
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Ingår i: Ship Technology Research. - 0937-7255. ; 53:1, s. 39-52
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Tidskriftsartikel (refereegranskat)abstract
- The blade geometry of a cavitating propeller in a given wake is optimized to maximize propeller efficiency and minimize propeller induced pressure fluctuations. The Keller criterion, the cavity volume and other constraints are considered in the optimization process. Such constraints are cavity area, cavity length and face side pressure and they are switched on separately or simultaneously to investigate their influence on cavitation and efficiency. Optimization is made starting from a near optimum propeller as well as from an off-design propeller. Results indicate that the present optimization technique can yield higher efficiency and lower pressure amplitude with tolerable cavitation for a cavitating propeller in a given wake.
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| 9. |
- Han, Kaijia, 1974, et al.
(författare)
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A procedure for optimizing cavitating propeller blades in agiven wake
- 2005
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Ingår i: 8th Numerical Towing Tank Symposium.
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Konferensbidrag (refereegranskat)abstract
- The blade geometry of a cavitating propeller in a given wake is optimized to maximize propeller efficiency and minimize propeller induced pressure fluctuations. The Keller criterion, the cavity volume and other constraints are considered in the optimization process. Such constraints are cavity area, cavity length and face side pressure and they are switched on separately or simultaneously to investigate their influence on cavitation and efficiency. Optimization is made starting from a near optimum propeller as well as from an off-design propeller. Results indicate that the present optimization technique can yield higher efficiency and lower pressure amplitude with tolerable cavitation for a cavitating propeller in a given wake.
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| 10. |
- Ibarz, Mercedes, et al.
(författare)
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Sepsis at ICU admission does not decrease 30-day survival in very old patients : a post-hoc analysis of the VIP1 multinational cohort study
- 2020
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Ingår i: Annals of Intensive Care. - : Springer. - 2110-5820. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine whether VIPs admitted for sepsis had different outcomes than those admitted for other acute reasons and identify potential prognostic factors for 30-day survival.RESULTS: This prospective study included VIPs with Sequential Organ Failure Assessment (SOFA) scores ≥ 2 acutely admitted to 307 ICUs in 21 European countries. Of 3869 acutely admitted VIPs, 493 (12.7%) [53.8% male, median age 83 (81-86) years] were admitted for sepsis. Sepsis was defined according to clinical criteria; suspected or demonstrated focus of infection and SOFA score ≥ 2 points. Compared to VIPs admitted for other acute reasons, VIPs admitted for sepsis were younger, had a higher SOFA score (9 vs. 7, p < 0.0001), required more vasoactive drugs [82.2% vs. 55.1%, p < 0.0001] and renal replacement therapies [17.4% vs. 9.9%; p < 0.0001], and had more life-sustaining treatment limitations [37.3% vs. 32.1%; p = 0.02]. Frailty was similar in both groups. Unadjusted 30-day survival was not significantly different between the two groups. After adjustment for age, gender, frailty, and SOFA score, sepsis had no impact on 30-day survival [HR 0.99 (95% CI 0.86-1.15), p = 0.917]. Inverse-probability weight (IPW)-adjusted survival curves for the first 30 days after ICU admission were similar for acute septic and non-septic patients [HR: 1.00 (95% CI 0.87-1.17), p = 0.95]. A matched-pair analysis in which patients with sepsis were matched with two control patients of the same gender with the same age, SOFA score, and level of frailty was also performed. A Cox proportional hazard regression model stratified on the matched pairs showed that 30-day survival was similar in both groups [57.2% (95% CI 52.7-60.7) vs. 57.1% (95% CI 53.7-60.1), p = 0.85].CONCLUSIONS: After adjusting for organ dysfunction, sepsis at admission was not independently associated with decreased 30-day survival in this multinational study of 3869 VIPs. Age, frailty, and SOFA score were independently associated with survival.
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| 11. |
- Larsson, Lars, 1945, et al.
(författare)
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Numerical optimisation of propeller-hull configurations at full scale
- 2006
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Ingår i: Proceedings of the Institute of Marine Engineering, Science and Technology Part A: Journal of Marine Engineering and Technology. - 1476-1548. ; A8
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Tidskriftsartikel (refereegranskat)abstract
- Optimisation of propeller/hull configurations based on the Reynolds-Averaged Navier-Stokes (RANS) equations has been very rare so far, due to the large computational effort required. Virtually no such optimisation has been carried out at full scale, where only a few RANS methods are at all applicable due to stability problems. The present paper introduces a newly developed RANS solver especially designed for stability and this solver is shown to work well at full scale. Through a link to a commonly used propeller analysis code predictions of the viscous flow around the full scale ship with an operating propeller may be made. This is utilized in the work reported here, where the flow codes are introduced into a system for automatic optimisation. It is shown that even well designed propellers may be further improved both in a fixed wake and in the wake behind a fixed hull.
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| 12. |
- Naddi, Leila, et al.
(författare)
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Ultrasound-guided subclavian vein catheterisation with a needle guide (ELUSIVE) : protocol for a randomised controlled study
- 2023
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Ingår i: BMJ Open. - 2044-6055. ; 13:12
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Central venous catheters are indispensable in modern healthcare. Unfortunately, they are accompanied by minor as well as major complications, leading to increased morbidity, mortality and costs. Immediate insertion-related complications (mechanical complications) have decreased due to the implementation of real-time ultrasound guidance, but they still occur and additional efforts to enhance patient safety are warranted. This study aims to investigate whether the use of a needle guide mounted on the ultrasound probe in subclavian catheterisations may decrease the number of catheterisations with >1 skin puncture (primary outcome).METHODS AND ANALYSIS: This is an investigator-initiated, non-commercial, randomised, controlled, parallel-group study conducted at Skåne University Hospital, Lund, Sweden. Adults (≥18 years) with a clinical indication for a subclavian central venous catheter and the ability to give written informed consent will be eligible for inclusion. Exclusion criteria include subclavian catheterisation deemed unsuitable based on the preprocedural ultrasound examination. Patients will be randomised to catheterisation by certified operators using a microconvex probe (long-axis, in-plane technique) with (n=150) or without (n=150) a needle guide. The ultrasound imaging from the procedures will be recorded and assessed by two reviewers individually. The assessors will be blinded for group affiliation. Secondary outcomes include the total number of skin punctures, mechanical complications, time to successful venous puncture, number of failed catheterisations and operator satisfaction with the needle guide at the end of the study period.Recruitment started on 8 November 2022 and will continue until the sample size is achieved.ETHICS AND DISSEMINATION: This study was approved by the Swedish Ethical Review Authority (#2022-04073-01) and the Swedish Medical Products Agency (#5.1-2022-52130; CIV-21-12-038367). The findings will be submitted to an international peer-reviewed journal.TRIAL REGISTRATION NUMBER: NCT05513378, clinicaltrials.gov.
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| 13. |
- Sabzevari, Hanif, 1981-
(författare)
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Varför tiger du? : Expositionen i sju enaktare av August Strindberg
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This is a study of how expository information is presented in the metatext (title, subtitle, prefaces, dedications, the dramatis personae, announcements of act and scene, stage directions etc.) and the dialogue in seven one-act plays by August Strindberg: The Stronger (1889), Pariah (1889), Simoom (1889), Debit and Credit (1892), The First Warning (1892), Facing Death (1892), and Motherly Love (1892). Exposition in this study is defined as a semiotic temporal-structural element that: (1) is not restricted to any specific part of the drama; (2) is present in both the metatext and the dialogue; (3) transfers information about the prescenic time/action (time/action preceding the scenic time/action), interscenic time/action (scenic and non-scenic time/action between scenes), simultaneous scenic time/action (non-scenic time/action that takes place simultaneously with the scenic time/action, and postscenic time/action (time/action that follows the scenic time/action). The study shows that the expository information is presented gradually in the dramas, in both metatext and dialogue, and in all the four categories of time/action presented above. One important result is that the seven one-act plays, despite their naturalistic qualities, also contain components pointing towards Strindberg’s more expressionistic drama. It is possible to talk about a naturalistic or an expressionistic period in Strindberg’s authorship. It is, however, impossible to regard Strindberg as a naturalist or an expressionist in a stricter sense. Strindberg’s drama is too complex and rich to be placed in a certain theoretic doctrine. It is clear from the dissertation that the study of expository information is useful in dramaturgic analyses, and generates various discussions about for example themes, motives, and metaphors. A complete analysis of the exposition, therefore, must also consider elements such as language and imagery.
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| 14. |
- Statkevicius, Svajunas, et al.
(författare)
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Albumin infusion rate and plasma volume expansion : A randomized clinical trial in postoperative patients after major surgery
- 2019
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly. Methods: Patients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a dose of 10 ml/kg (ideal body weight) either rapidly (30 min) or slowly (180 min). Plasma volume was measured using radiolabeled albumin at baseline, at 30 min, and at 180 min after the start of infusion. Primary outcome was change in plasma volume from the start of infusion to 180 min after the start of infusion. Secondary outcomes included the change in the area under the plasma volume curve and transcapillary escape rate (TER) for albumin from 180 to 240 min after the start of albumin infusion. Results: A total of 33 and 31 patients were included in the analysis in the slow and rapid groups, respectively. The change in plasma volume from the start of infusion to 180 min did not differ between the slow and rapid infusion groups (7.4 ± 2.6 vs. 6.5 ± 4.1 ml/kg; absolute difference, 0.9 ml/kg [95%CI, - 0.8 to 2.6], P = 0.301). Change in the area under the plasma volume curve was smaller in the slow than in the rapid infusion group and was 866 ± 341 and 1226 ± 419 min ml/kg, respectively, P < 0.001. TER for albumin did not differ and was 5.3 ± 3.1%/h and 5.4 ± 3%/h in the slow and in the rapid infusion groups, respectively, P = 0.931. Conclusions: This study does not support our hypothesis that a slow infusion of colloid results in a greater plasma volume expansion than a rapid infusion. Instead, our result of a smaller change in the area under the plasma volume curve indicates that a slow infusion results in a less efficient plasma volume expansion, but further studies are required to confirm this finding. A rapid infusion has no effect on vascular leak as measured after completion of the infusion. Trial registration: EudraCT2013-004446-42 registered December 23, 2014.
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| 15. |
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