| 1. |
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| 2. |
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| 3. |
- Angelini, Marco, et al.
(författare)
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Collaborative environment of the promise infrastructure : An elegant approach
- 2012
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Ingår i: CEUR Workshop Proceedings. ; , s. 55-58
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Konferensbidrag (refereegranskat)abstract
- This paper focuses on developing lightweight tools for knowledge sharing and collaboration by communities of practice operating in the field of information retrieval. The paper contributes a motivating scenario, a characterization of these communities, a list of requirements for collaboration, and then a system design proposed as a proof-of-concept implementation that is being evaluated.
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| 4. |
- Ardila-Ardila, A., et al.
(författare)
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HUMANS: una batería neuropsicologica para la evaluación de pacientes infectados con VIH-1 : [Humans: a neuropsychological battery for evaluating HIV-1 infected patients]
- 2003
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Ingår i: Revista de Neurocirugía. - 1514-3716. ; 36:8, s. 756-762
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Forskningsöversikt (refereegranskat)abstract
- Objective. To develop a neuropsychological test battery in Spanish for the cognitive evaluation of HIV-1 infected patients. Development. Departing from the suggestions presented by the work group of the National Institute of Mental Health (USA), a neuropsychological assessment battery was developed. It was named HUMANS (HIV/University of Miami Annotated Neuropsychological test battery in Spanish). This battery includes the following domains: 1) attention and speed of processing information, 2) memory, 3) executive function, 4) language, 5) visuospacial/visuoconstructive abilities, and 6) motor abilities. Administration takes about 3-4 hours. The English parallel version of this battery has been successfully used in English for over a decade with HIV-1 infected patients. In the paper the development and adaptation to Spanish language of the HUMANS neuropsychology section is presented Conclusions. HUMANS neuropsychological test battery fulfill the recommendations presented by the workgroup of the National Institute of Mental Health for evaluating HIV-1 infected patients. Studies regarding validity and reliability are still required.
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| 5. |
- Bartolini, Barbara, et al.
(författare)
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Iduronic Acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells.
- 2013
-
Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:7
-
Tidskriftsartikel (refereegranskat)abstract
- Aortic smooth muscle cells produce chondroitin/dermatan sulfate (CS/DS) proteoglycans that regulate extracellular matrix organization and cell behavior in normal and pathological conditions. A unique feature of CS/DS proteoglycans is the presence of iduronic acid (IdoA), catalyzed by two DS epimerases. Functional ablation of DS-epi1, the main epimerase in these cells, resulted in a major reduction of IdoA both on cell surface and in secreted CS/DS proteoglycans. Downregulation of IdoA led to delayed ability to re-populate wounded areas due to loss of directional persistence of migration. DS-epi1-/- aortic smooth muscle cells, however, had not lost the general property of migration showing even increased speed of movement compared to wild type cells. Where the cell membrane adheres to the substratum, stress fibers were denser whereas focal adhesion sites were fewer. Total cellular expression of focal adhesion kinase (FAK) and phospho-FAK (pFAK) was decreased in mutant cells compared to control cells. As many pathological conditions are dependent on migration, modulation of IdoA content may point to therapeutic strategies for diseases such as cancer and atherosclerosis.
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| 6. |
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| 7. |
- Bartolini, Barbara, et al.
(författare)
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Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition.
- 2012
-
Ingår i: Glycobiology. - : Oxford University Press (OUP). - 1460-2423 .- 0959-6658. ; 22:7, s. 1007-1016
-
Tidskriftsartikel (refereegranskat)abstract
- Dermatan sulfate epimerase 2 (DS-epi2), together with its homologue DS-epi1, transform glucuronic acid into iduronic acid in dermatan sulfate polysaccharide chains. Iduronic acid gives dermatan sulfate increased chain flexibility and promotes protein binding. DS-epi2 is ubiquitously expressed and is the predominant epimerase in brain. Here we report the generation and initial characterization of DS-epi2 null mice. DS-epi2 deficient mice showed no anatomical, histological or morphological abnormalities. The body weights and lengths of mutated and wild-type littermates were indistinguishable. They were fertile and had a normal lifespan. Chondroitin/dermatan sulfate (CS/DS) isolated from newborn mutated mouse brains had a 38% reduction in iduronic acid compared to wild type littermates and compositional analysis revealed a decrease of 4-O-sulfate and an increase of 6-O-sulfate containing structures. Despite the reduction in iduronic acid, adult DS-epi2-/- brain showed normal extracellular matrix features by immunohistological stainings. We conclude that DS-epi1 compensates in vivo for the loss of DS-epi2.. These results extend previous findings of functional redundancy of brain extracellular matrix components.
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| 8. |
- Bartolini Bussi, M G, et al.
(författare)
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Mathematics in context: focusing on students
- 2009
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Ingår i: Challenging Mathematics In and Beyond the Classroom – The 16th ICMI Study. - New York : Springer Science+Business Media B.V.. - 9780387096032 ; , s. 171-203
-
Bokkapitel (refereegranskat)abstract
- This chapter presents nine case studies in which school students engage in challenging mathematics outside their immediate classroom environment. In each case, students are encouraged to collaborate in investigations that go beyond the standard curriculum and creatively use the ingredients of the particular context. In Italy, students visit a mathematical laboratory to understand and utilize mathematical machines. Morning assembly at an Indian school brings students from many classes together in the solution of mathematical problems. Four of the projects are from France: students analyze the configuration of a heap of sand, pursue astronomical investigations with software, obtain a flavor of research by having secondary school teams investigate interesting problems, and are presented at all levels with open-ended research problems. There are three programs from the United States, the first, an advanced geometry sequence for secondary students completing the regular syllabus early, the second, activities arising from exhibits in an art museum, and the third, using the school lawn to deepen student understanding of geometric constructions. All such activities need to be evaluated for their effectiveness, so that they move from just being initiatives of dynamic individuals to serve as the foundation for systemic improvements in the way in which students learn, understand and use mathematics. In the early part of this chapter, we briefly mention how research into such activities might be approached.
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| 9. |
- Bartolini, Davide Basilio, et al.
(författare)
-
The Autonomic Operating System Research Project - Achievements and Future Directions
- 2013
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Konferensbidrag (refereegranskat)abstract
- Traditionally, hypervisors, operating systems, and runtime systems have been providing an abstraction layer over the bare-metal hardware. Traditional abstractions, however, do not consider for non-functional requirements such as system-level constraints or users' objectives. As these requirements are gaining increasing importance, researchers are looking into making user-specified and system-level objectives first-class citizens in the computer systems' realm. This paper describes the Autonomic Operating System (AcOS) project; AcOS enhances commodity operating systems with an autonomic layer that enables self-* properties through adaptive resource allocation. With AcOS, we investigate intelligent resource allocation to achieve user-specified service-level objectives on application performance and to respect system-level thresholds on CPU temperature. We give a broad overview of \system, elaborate on its achievements, and discuss research perspectives.
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| 10. |
- Bartolini, Gabriel, et al.
(författare)
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On automorphisms groups of cyclic p-gonal Riemann surfaces
- 2013
-
Ingår i: Journal of symbolic computation. - : Elsevier. - 0747-7171 .- 1095-855X. ; 57, s. 61-69
-
Tidskriftsartikel (refereegranskat)abstract
- In this work we obtain the group of conformal and anticonformal automorphisms of real cyclic p-gonal Riemann surfaces, where p⩾3p⩾3 is a prime integer and the genus of the surfaces is at least (p−1)2+1(p−1)2+1. We use Fuchsian and NEC groups, and cohomology of finite groups.
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| 11. |
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| 12. |
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| 13. |
- Bartolini, Gabriel, 1983-
(författare)
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On the Branch Loci of Moduli Spaces of Riemann Surfaces
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The spaces of conformally equivalent Riemann surfaces, Mg where g ≥ 1, are not manifolds. However the spaces of the weaker Teichmüller equivalence, Tg are known to be manifolds. The Teichmüller space Tg is the universal covering of Mg and Mg is the quotient space by the action of the modular group. This gives Mg an orbifold structure with a branch locus Bg. The branch loci Bg can be identified with Riemann surfaces admitting non-trivial automorphisms for surfaces of genus g ≥ 3. In this thesis we consider the topological structure of Bg. We study the connectedness of the branch loci in general by considering families of isolated strata and we we establish that connectedness is a phenomenon for low genera. Further, we give the orbifold structure of the branch locus of surfaces of genus 4 and genus 5 in particular, by studying the equisymmetric stratification of the branch locus.Paper 1. In this paper we show that the strata corresponding to actions of order 2 and 3 belong to the same connected component for arbitrary genera. Further we show that the branch locus is connected with the exception of one isolated point for genera 5 and 6, it is connected for genus 7 and it is connected with the exception of two isolated points for genus 8.Paper 2. This paper contains a collection of results regarding components of the branch loci, some of them proved in detail in other papers. It is shown that for any integer d if p is a prime such that p > (d + 2)2, there there exist isolated strata of dimension d in the moduli space of Riemann surfaces of genus (d + 1)(p − 1)/2. It is also shown that if we consider Riemann surfaces as Klein surfaces, the branch loci are connected for every genera due to reflections.Paper 3. Here we consider surfaces of genus 4 and 5. Here we study the automorphism groups of Riemann surfaces of genus 4 and 5 up to topological equivalence and determine the complete structure of the equisymmetric stratification of the branch locus.Paper 4. In this paper we establish that the connectedness of the branch loci is a phenomenon for low genera. More precisely we prove that the only genera g where Bg is connected are g = 3, 4, 13, 17, 19, 59.
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| 14. |
- Bartolini, Gabriel, 1983-
(författare)
-
On the Branch Loci of Moduli Spaces of Riemann Surfaces of Low Genera
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Compact Riemann surfaces of genus greater than 1 can be realized as quotient spaces of the hyperbolic plane by the action of Fuchsian groups. The Teichmüller space is the set of all complex structures of Riemann surfaces and the moduli space the set of conformal equivalence classes of Riemann surfaces. For genus greater than two the branch locus of the covering of the moduli space by the Teichmüller space can be identified wi the set of Riemann surfaces admitting non-trivial automorphisms. Here we give the orbifold structure of the branch locus of surfaces of genus 5 by studying the equisymmetric stratification of the branch locus. This gives the orbifold structure of the moduli space.We also show that the strata corresponding to surfaces with automorphisms of order 2 and 3 belong to the same connected component for every genus. Further we show that the branch locus is connected with the exception of one isolated point for genera 5 and 6, it is connected for genus 7 and it is connected with the exception of two isolated points for genus 8.
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| 15. |
- Bartolini, Gabriel
(författare)
-
On the connected branch loci of moduli spaces
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The moduli space Mg of compact Riemann surfaces of genus g has orbifold structure and the set of singular points of such orbifold is the branch locus Bg. In this article we show that Bg is connected exactly for genera three, four, thirteen, seventeen, nineteen and fitfynine by the use automorphisms of order 5 and 7 of Riemann surfaces, and calculations with GAP for some small genera.
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| 16. |
- Bartolini, Gabriel, et al.
(författare)
-
On the connectedness of the branch locus of the moduli space of Riemann surfaces
- 2010
-
Ingår i: REVISTA DE LA REAL ACADEMIA DE CIENCIAS EXACTAS FISICAS Y NATURALES SERIE A-MATEMATICAS. - : REAL ACAD CIENCIAS EXACTAS FISICAS and NATURALES, CALLE VALVERDE 22, MADRID, 28004, SPAIN. - 1578-7303. ; 104:1, s. 81-86
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Tidskriftsartikel (refereegranskat)abstract
- The moduli space M-g of compact Riemann surfaces of genus g has the structure of an orbifold and the set of singular points of such orbifold is the branch locus B-g. In this article we present some results related with the topology of B-g. We study the connectedness of B-g for g andlt;= 8, the existence of isolated equisymmetric strata in the branch loci and finally we stablish the connectedness of the branch locus of the moduli space of Riemann surfaces considered as Klein surfaces. We just sketch the proof of some of the results; complete proofs will be published elsewhere.
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| 17. |
- Bartolini, Gabriel, et al.
(författare)
-
On the connectedness of the branch locus of the moduli space of Riemann surfaces of low genus
- 2012
-
Ingår i: Proceedings of the American Mathematical Society. - : American Mathematical Society. - 0002-9939 .- 1088-6826. ; 140:1, s. 35-45
-
Tidskriftsartikel (refereegranskat)abstract
- Let be an integer and let , where denotes the moduli space of compact Riemann surfaces of genus . Using uniformization of Riemann surfaces by Fuchsian groups and the equisymmetric stratification of the branch locus of the moduli space, we prove that the subloci corresponding to Riemann surfaces with automorphism groups isomorphic to cyclic groups of order 2 and 3 belong to the same connected component. We also prove the connectedness of for and with the exception of the isolated points given by Kulkarni.
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| 18. |
- Bartolini, Gabriel, et al.
(författare)
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ON THE CONNECTIVITY OF BRANCH LOCI OF MODULI SPACES
- 2013
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Ingår i: Annales Academiae Scientiarum Fennicae Mathematica. - : Academia Scientiarum Fennica. - 1239-629X .- 1798-2383. ; 38:1, s. 245-258
-
Tidskriftsartikel (refereegranskat)abstract
- The moduli space M-g of compact Riemann surfaces of genus g has orbifold structure and the set of singular points of the orbifold is the branch locus B-g. In this article we show that B-g is connected for genera three, four, thirteen, seventeen, nineteen and fiftynine, and disconnected for any other genus. In order to prove this we use Fuchsian groups, automorphisms of order 5 and 7 of Riemann surfaces, and calculations with GAP for some small genera.
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| 19. |
- Bartolini, Gabriel, et al.
(författare)
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On the Orbifold Structure of the Moduli Space of Riemann Surfaces of Genera Four and Five
- 2014
-
Ingår i: REVISTA DE LA REAL ACADEMIA DE CIENCIAS EXACTAS FISICAS Y NATURALES SERIE A-MATEMATICAS. - : Springer. - 1578-7303 .- 1579-1505. ; 108:2, s. 769-793
-
Tidskriftsartikel (refereegranskat)abstract
- The moduli space Mg, of compact Riemann surfaces of genus g has orbifold structure since Mg is the quotient space of the Tiechmüller space by the action of the mapping class group. Using uniformization of Riemann surfaces by Fuchsian groups and the equisymmetric stratification of the branch locus of the moduli space we find the orbifold structure of the moduli spaces of Riemann surfaces of genera 4 and 5.
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| 20. |
- Bartolini, Nadia, et al.
(författare)
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Assembling alternative futures for heritage
- 2018
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Ingår i: Context. - Tisbury, UK : Institute of Historic Building Conservation. - 0958-2746. ; :155, s. 22-24
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 21. |
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| 22. |
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| 23. |
- Ciucani, Marta Maria, et al.
(författare)
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Evolutionary history of the extinct Sardinian dhole
- 2021
-
Ingår i: Current biology : CB. - : Elsevier BV. - 1879-0445 .- 0960-9822. ; 31, s. 1-9
-
Tidskriftsartikel (refereegranskat)abstract
- The Sardinian dhole (Cynotherium sardous)1 was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene.2-5 Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African hunting dog ancestor.3,6-9 Morphometric analyses3,6,8-12 have failed to clarify the evolutionary relationship with other canids.We sequenced the genome of a ca-21,100-year-old Sardinian dhole in order to understand its genomic history and clarify its phylogenetic position. We found that it represents a separate taxon from all other living canids from Eurasia, Africa, and North America, and that the Sardinian dhole lineage diverged from the Asian dhole ca 885 ka. We additionally detected historical gene flow between the Sardinian and Asian dhole lineages, which ended approximately 500-300 ka, when the land bridge between Sardinia and mainland Italy was already broken, severing their population connectivity. Our sample showed low genome-wide diversity compared to other extant canids-probably a result of the long-term isolation-that could have contributed to the subsequent extinction of the Sardinian dhole.
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| 24. |
- Eckerberg, Katarina, 1953-, et al.
(författare)
-
Evaluation of the Social Sciences in Norway : Report from Panel 3 – Political Science
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Panel 3 evaluated 53 units in all, 22 institutional units and 31 research groups. The evaluation included university departments of political science, political scientists working in interdisciplinary units at universities and university colleges, and political scientists working at interdisciplinary research institutes.Broadly speaking, Norwegian Political Science is doing well. Our assessments of the scientific output across institutes and research groups show that the impact varies between fair and excellent, even though we underline the limitations of such an oversimplified classification scheme. The panel observes variation in the scientific quality impact of institutions, especially within the Oslo region compared with most other parts of Norway. The majority of subdisciplines are well covered. A substantial number of studies focus on conflict, peace and policy studies (food, climate, energy etc.). Much of the research focuses on Norway and is directly relevant to Norwegian society. Some of the work makes significant theoretical contributions, but most of it mainly offers a strong empirical dimension.However, some areas receive relatively little attention, such as classical and modern political theory, political economy and political history. The range of comparative work could also be broader. Given the available human capital, funding and other resources, the panel finds that Political Science in Norway is not realising its full potential. There is a tendency – at both the research institutes and universities – to rely too much on policy-oriented research funding, which might be an obstacle to pursuing more innovative and ground-breaking conceptual work. Likewise, the recruitment of a new generation of political scientists in the form of PhD students and postdocs is largely driven by project funding, thereby limiting their scope to develop their own topics or ideas. A few institutions have accessed international (mainly EU) funding, but the many smaller units lack the scale and resources required to compete for such funds. These researchers would do well to develop (counter-) strategies that enable them to participate in larger projects, including H2020 proposals. Diversification of funding is a general recommendation for the majority of evaluated units.The panel’s assessment of research groups revealed considerable variation between the institutes with regard to their purpose and ‘social life’. The panel considers a constructive and enabling research environment to be the most valuable function of a research group, while at the same time ensuring that individual researchers have autonomy to develop their own research agendas. The panel notes that many of the high-scoring research groups have a good support structure within their departments or institutions, whereas some of the weaker ones lack such support. Joint activities aimed at raising scientific quality, such as regular work-in-progress seminars, article or book manuscript review sessions, mock research grant interviews, staff retreats, and (international) guest speakers, are ways of going forward. More could also be done to target high-profile international journals and publishers, while maintaining a broader perspective on modes of scientific output beyond peer-reviewed articles.In light of the considerable organisational fragmentation of Political Science in Norway, and corresponding problems of scale, more collaboration across institutions within the country is generally desirable. Researcher mobility within Norway and internationally could also be expanded. This could to help to bring political science environments closer together, both in their research and in PhD and postdoc training, thereby strengthening Political Science as a discipline.
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| 25. |
- Fabini, Edoardo, et al.
(författare)
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Unveiling the Biochemistry of the Epigenetic Regulator SMYD3
- 2019
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Ingår i: Biochemistry. - : AMER CHEMICAL SOC. - 0006-2960 .- 1520-4995. ; 58:35, s. 3634-3645
-
Tidskriftsartikel (refereegranskat)abstract
- SET and MYND domain-containing protein 3 (SMYD3) is a lysine methyltransferase that plays a central role in a variety of cancer diseases, exerting its pro-oncogenic activity by methylation of key proteins, of both nuclear and cytoplasmic nature. However, the role of SMYD3 in the initiation and progression of cancer is not yet fully understood and further biochemical characterization is required to support the discovery of therapeutics targeting this enzyme. We have therefore developed robust protocols for production, handling, and crystallization of SMYD3 and biophysical and biochemical assays for clarification of SMYD3 biochemistry and identification of useful lead compounds. Specifically, a time-resolved biosensor assay was developed for kinetic characterization of SMYD3 interactions. Functional differences in SMYD3 interactions with its natural small molecule ligands SAM and SAH were revealed, with SAM forming a very stable complex. A variety of peptides mimicking putative substrates of SMYD3 were explored in order to expose structural features important for recognition. The interaction between SMYD3 and some peptides was influenced by SAM. A nonradioactive SMYD3 activity assay using liquid chromatography-mass spectrometry (LC-MS) analysis explored substrate features of importance also for methylation. Methylation was notable only toward MAP kinase kinase kinase 2 (MAP3K2_K-260)-mimicking peptides, although binary and tertiary complexes were detected also with other peptides. The analysis supported a random bi-bi mechanistic model for SMYD3 methyltransferase catalysis. Our work unveiled complexities in SMYD3 biochemistry and resulted in procedures suitable for further studies and identification of novel starting points for design of effective and specific leads for this potential oncology target.
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| 26. |
- Galbrun, Bruno, et al.
(författare)
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“Short” or “long” Rhaetian ? Astronomical calibration of Austrian key sections
- 2020
-
Ingår i: Global and Planetary Change. - : Elsevier BV. - 0921-8181. ; 192
-
Tidskriftsartikel (refereegranskat)abstract
- The establishment of the Late Triassic time scale has given rise to considerable controversy, particularly regarding the Rhaetian duration and the inferred absolute age models. In this respect the astronomical polarity time scale (APTS) established from the continental successions of the Newark Basin (eastern North America) is considered as a reference record, although its completeness is questioned. Numerous magnetostratigraphic correlation schemes have been proposed between the APTS and biostratigraphically well-constrained Tethyan marine sections. This has led to two main contrasting options: a “short” Rhaetian duration (about 4–5 myr), and a “long” one (about 8–9 myr). Astronomical calibration of the Tethyan Rhaetian and estimate of its duration is necessary to help advance this debate. We have undertaken a cyclostratigraphic analysis of a Rhaetian composite record built from four overlapping Austrian reference sections. Magnetic susceptibility variations of the 131.5 m thick record are astronomically paced by the precession and 405-kyr orbital eccentricity cycles. 405-kyr orbital tuning allows to establish a floating time scale, and thus to suggest a minimum duration of 6.69 myr of the Rhaetian stage. Given the well-established radioisotopic age of the Rhaetian-Hettangian boundary of 201.36 Ma, an age no younger than 208.05 Ma for the Norian-Rhaetian boundary can be proposed. This result will contribute to the refinement of the Late Triassic time scale, but it does not solve the long-standing debate on bio-magnetostratigraphic correlations between the continental Newark APTS and the Tethyan marine sections, nor the question of the completeness of the Rhaetian Newark Basin.
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| 27. |
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| 28. |
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| 29. |
- Gruber, CEM, et al.
(författare)
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Geographical Variability Affects CCHFV Detection by RT-PCR: A Tool for In-Silico Evaluation of Molecular Assays
- 2019
-
Ingår i: Viruses. - : MDPI AG. - 1999-4915. ; 11:10
-
Tidskriftsartikel (refereegranskat)abstract
- The Crimean–Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations. The high genetic variability of CCHFV often hampers the efficacy of available molecular tests and can affect their diagnostic potential. Recently, increasing numbers of complete CCHFV genomic sequences have become available, allowing a better appreciation of the genomic evolution of this virus. We summarized the current knowledge on molecular methods and developed a new bioinformatics tool to evaluate the existing assays for CCHFV detection, with a special focus on strains circulating in different geographical areas. Twenty-two molecular methods and 181 sequences of CCHFV were collected, respectively, from PubMed and GenBank databases. Up to 28 mismatches between primers and probes of each assay and CCHFV strains were detected through in-silico PCR analysis. Combinations of up to three molecular methods markedly decreased the number of mismatches within most geographic areas. These results supported the good practice of CCHFV detection of performing more than one assay, aimed for different sequence targets. The choice of the most appropriate tests must take into account patient’s travel history and geographic distribution of the different CCHFV strains.
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| 30. |
- Guiomar, N., et al.
(författare)
-
Typology and distribution of small farms in Europe : Towards a better picture
- 2018
-
Ingår i: Land use policy. - : Elsevier BV. - 0264-8377 .- 1873-5754. ; 75, s. 784-798
-
Tidskriftsartikel (refereegranskat)abstract
- The contribution of small farms to local food supply, food security and food sovereignty is widely acknowledged at a global level. In the particular case of Europe, they often are seen as an alternative to large and specialised farms. Assessing the real role of small farms has been limited by a lack of information, as small farms are frequently omitted from agricultural censuses and national statistics. It is also well acknowledged that small farms differ widely, and are distributed according to different spatial patterns across Europe, fulfilling different roles according to the agriculture and territorial characteristics of each region. This paper presents the result of a novel classification of small farms at NUTS-3 level in Europe, according to the relevance of small farms in the agricultural and territorial context of each region, and based on a typology of small farms considering different dimensions of farm size. The maps presented result from an extensive data collection and variables selected according to European wide expert judgement, analysed with advanced cluster procedures. The results provide a fine grained picture of the role of small farms at the regional level in Europe today, and are expected to support further data analysis and targeted policy intervention.
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| 31. |
- Harrison, Rodney, et al.
(författare)
-
Discussion and conclusions
- 2020
-
Ingår i: Heritage Futures. - London : UCL Press. - 9781787356009 - 9781787356023 - 9781787356016 - 9781787356030 - 9781787356047 ; , s. 465-488
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Bokkapitel (refereegranskat)
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| 32. |
- Harrison, Rodney, et al.
(författare)
-
Heritage Futures
- 2016
-
Ingår i: Archaeology International. - : Ubiquity Press. - 1463-1725 .- 2048-4194. ; 19, s. 19-72
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Heritage Futures is a four-year collaborative international research programme (2015–2019) funded by a UK Arts and Humanities Research Council (AHRC) ‘Care for the Future’ Theme Large Grant, and supported additionally by its host universities and partner organisations. The research programme involves ambitious interdisciplinary research to explore the potential for innovation and creative exchange across a broad range of heritage and related fields, in partnership with a number of academic and non-academic institutions and interest groups. It is distinctive in its comparative approach which aims to bring heritage conservation practices of various forms into closer dialogue with the management of other material and virtual legacies such as nuclear waste management. It is also distinctive in its exploration of different forms of heritage as future-making practices. This brief paper provides an introduction to the research programme and its aims and methods.
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| 33. |
-
Heritage Futures : Comparative Approaches to Natural and Cultural Heritage Practices
- 2020
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Preservation of natural and cultural heritage is often said to be something that is done for the future, or on behalf of future generations, but the precise relationship of such practices to the future is rarely reflected upon. Heritage Futures draws on research undertaken over four years by an interdisciplinary, international team of 16 researchers and more than 25 partner organisations to explore the role of heritage and heritage-like practices in building future worlds.Engaging broad themes such as diversity, transformation, profusion and uncertainty, Heritage Futures aims to understand how a range of conservation and preservation practices across a number of countries assemble and resource different kinds of futures, and the possibilities that emerge from such collaborative research for alternative approaches to heritage in the Anthropocene. Case studies include the cryopreservation of endangered DNA in frozen zoos, nuclear waste management, seed biobanking, landscape rewilding, social history collecting, space messaging, endangered language documentation, built and natural heritage management, domestic keeping and discarding practices, and world heritage site management.
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| 34. |
- Kang, Yong-Bin, et al.
(författare)
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A computer-facilitated method for matching incident cases using semantic similarity measurement
- 2009
-
Ingår i: 2009 IFIP/IEEE International Symposium on Integrated Network Management. - Piscataway, NJ : IEEE Communications Society. - 9781424434862 ; , s. 10-19
-
Konferensbidrag (refereegranskat)abstract
- This paper presents a new computer-facilitated approach for incident management to improve typical incident management. Our approach automates typical manual-based incident resolution process by proposing a new semantic similarity measurement between a given incident call and incident cases stored already in a case base. The proposed semantic similarity measurement distinguishes traditional similarity measures by incorporating additional useful information and exploiting semantic knowledge about features appeared in two incident descriptions to be compared. First, we state how typical incident management is processed and what its problems are. We then propose our automated incident resolution process with its core components. After that we introduce our identified additional useful information for our similarity measurement and describe how our similarity measurement algorithm is carried out. In an experimental evaluation, we show the technical coherence and feasibility of the proposed solution using a real dataset.
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| 35. |
- Kang, Yong-Bin, et al.
(författare)
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A knowledge-rich similarity measure for improving IT incident resolution process
- 2010
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Ingår i: Proceedings of the 25th Annual ACM Symposium on Applied Computing 2010. - New York : ACM Digital Library. - 9781605586397 ; , s. 1781-1788
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Konferensbidrag (refereegranskat)abstract
- The aim of incident management is to restore a given IT service disruption, simply called incident, to normal state as quickly as possible. In incident management, it is essential to resolve a new incident efficiently and accurately. However, typically, incident resolution process is largely manual, thus, it is time-consuming and error-prone. This paper proposes a new knowledge-rich similarity measure for improving this process. The role of this measure is to retrieve the most similar past incident cases for a new incident without human intervention. The solution information contained the retrieved incident cases can be utilized to resolve the new incident. The main feature of our similarity measure is to incorporate additional useful meta knowledge, outside of incident description that is the only exploited information in typical similarity measures used in CBR, to improve effectiveness. Moreover, this measure exploits as much semantic knowledge as possible about features contained in previous incident cases. Through an experimental evaluation, we show the effectiveness, technical coherence and feasibility of this measure using a real dataset
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| 36. |
- Kunkel, Julian Martin, et al.
(författare)
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DECICE : Device-Edge-Cloud Intelligent Collaboration Framework
- 2023
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Ingår i: Proceedings of the 20th ACM International Conference on Computing Frontiers 2023, CF 2023. - : Association for Computing Machinery (ACM). ; , s. 266-271
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Konferensbidrag (refereegranskat)abstract
- DECICE is a Horizon Europe project that is developing an AI-enabled open and portable management framework for automatic and adaptive optimization and deployment of applications in computing continuum encompassing from IoT sensors on the Edge to large-scale Cloud/HPC computing infrastructures. In this paper, we describe the DECICE framework and architecture. Furthermore, we highlight use-cases for framework evaluation: intelligent traffic intersection, magnetic resonance imaging, and emergency response.
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| 37. |
- Macfarlane, M. D., et al.
(författare)
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Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: Results from a subset of the ladis study
- 2015
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Ingår i: The American journal of geriatric psychiatry. - : Elsevier BV. - 1064-7481. ; 23:1, s. 59-
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Tidskriftsartikel (refereegranskat)abstract
- Objective Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction. Methods Magnetic resonance imaging scans and clinical gait/balance data (scores from the Short Physical Performance Battery [SPPB]) were sourced from 66 subjects in the previously published LADIS trial, performed in nondisabled individuals older than age 65 years with WMHs at study entry. Data were obtained at study entry and at 3-year follow-up. Caudate nuclei and putamina were manually traced using a previously published method and volumes calculated. The relationships between volume and physical performance on the SPPB were investigated with shape analysis using the spherical harmonic shape description toolkit. Results There was no correlation between the severity of WMHs and striatal volumes. Caudate nuclei volume correlated with performance on the SPPB at baseline but not at follow-up, with subsequent shape analysis showing left caudate changes occurred in areas corresponding to inputs of the dorsolateral prefrontal, premotor, and motor cortex. There was no correlation between putamen volumes and performance on the SPPB. Conclusion Disruption in frontostriatal circuits may play a role in mediating poorer physical performance in individuals with WMHs. Striatal volume and shape changes may be suitable biomarkers for functional changes in this population. © 2015 American Association for Geriatric Psychiatry.
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| 38. |
- Madurell-Malapeira, Joan, et al.
(författare)
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First small-sized Dinofelis: Evidence from the Plio-Pleistocene of North Africa
- 2021
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Ingår i: Quaternary Science Reviews. - Amsterdam : Elsevier. - 0277-3791 .- 1873-457X. ; 265
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Tidskriftsartikel (refereegranskat)abstract
- We describe small-sized specimens of the metailurine felid Dinofelis from a new Plio-Pleistocene site in North Africa. Dinofelis is a genus of saber-toothed cats mainly recorded from East and South Africa with numerous leopard to jaguar-sized species. The described specimens, clearly smaller than all the other African Dinofelis, resemble isolated remains from the Late Pliocene of France and the Early Pleistocene of Africa. Present evidence suggests that our form represents a new species and/or new lineage of Dinofelis, smaller and probably occupying a different ecological niche compared to the previously known members of the genus, and thus it adds complexity to the high intraspecific competition among large carnivorans in the Plio-Pleistocene of Africa.
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| 39. |
- Malmström, Anders, et al.
(författare)
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Iduronic Acid in Chondroitin/Dermatan Sulfate: Biosynthesis and Biological Function
- 2012
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Ingår i: Journal of Histochemistry and Cytochemistry. - : SAGE Publications. - 0022-1554 .- 1551-5044. ; 60:12, s. 916-925
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Tidskriftsartikel (refereegranskat)abstract
- The ability of chondroitin/dermatan sulfate (CS/DS) to convey biological information is enriched by the presence of iduronic acid. DS-epimerases 1 and 2 (DS-epi1 and 2), in conjunction with DS-4-O-sulfotransferase 1, are the enzymes responsible for iduronic acid biosynthesis and will be the major focus of this review. CS/DS proteoglycans (CS/DS-PGs) are ubiquitously found in connective tissues, basement membranes, and cell surfaces or are stored intracellularly. Such wide distribution reflects the variety of biological roles in which they are involved, from extracellular matrix organization to regulation of processes such as proliferation, migration, adhesion, and differentiation. They play roles in inflammation, angiogenesis, coagulation, immunity, and wound healing. Such versatility is achieved thanks to their variable composition, both in terms of protein core and the fine structure of the CS/DS chains. Excellent reviews have been published on the collective and individual functions of each CS/DS-PG. This short review presents the biosynthesis and functions of iduronic acid-containing structures, also as revealed by the analysis of the DS-epi1- and 2-deficient mouse models. (J Histochem Cytochem 60: 916-925, 2012)
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| 40. |
- Mathewson, Kent, et al.
(författare)
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Patina : a profane archaeology
- 2019
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Ingår i: AAG Review of Books. - : Taylor & Francis. - 2325-548X. ; 7:2, s. 113-125
-
Recension (refereegranskat)
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| 41. |
- Padovitz, Amir, et al.
(författare)
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An approach to data fusion for context awareness
- 2005
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Ingår i: Modeling and Using Context. - Berlin : Encyclopedia of Global Archaeology/Springer Verlag. - 9783540269243 ; , s. 353-367
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Konferensbidrag (refereegranskat)abstract
- We propose and develop an approach modeled with multi-attribute utility theory for sensor fusion in context-aware environments. Our approach is distinguished from existing general purpose fusion techniques by a number of factors including a general underlying context model it is built upon and a set of heuristics it covers. The technique is developed for context-aware applications and we argue that it provides various advantages for data fusion in context-aware scenarios. We experimentally evaluate our approach with actual use cases using real sensors.
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| 42. |
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| 43. |
- Parenti, Marco Daniele, et al.
(författare)
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Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3
- 2022
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Ingår i: European Journal of Medicinal Chemistry. - : Elsevier. - 0223-5234 .- 1768-3254. ; 243
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Tidskriftsartikel (refereegranskat)abstract
- Recent findings support the hypothesis that inhibition of SMYD3 methyltransferase may be a therapeutic avenue for some of the deadliest cancer types. Herein, active site-selective covalent SMYD3 inhibitors were designed by introducing an appropriate reactive cysteine trap into reversible first-generation SMYD3 inhibitors. The 4-amino-piperidine derivative EM127 (11C) bearing a 2-chloroethanoyl group as reactive warhead showed selectivity for Cys186, located in the substrate/histone binding pocket. Selectivity towards Cys186 was retained even at high inhibitor/enzyme ratio, as shown by mass spectrometry. The mode of interaction with the SMYD3 substrate/ histone binding pocket was revealed by crystallographic studies. In enzymatic assays, 11C showed a stronger SMYD3 inhibitory effect compared to the reference inhibitor EPZ031686. Remarkably, 11C attenuated the proliferation of MDA-MB-231 breast cancer cell line at the same low micromolar range of concentrations that reduced SMYD3 mediated ERK signaling in HCT116 colorectal cancer and MDA-MB-231 breast cancer cells. Furthermore, 11C (5 mu M) strongly decreased the steady-state mRNA levels of genes important for tumor biology such as cyclin dependent kinase 2, c-MET, N-cadherin and fibronectin 1, all known to be regulated, at least in part, by SMYD3. Thus, 11C is as a first example of second generation SMYD3 inhibitors; this agent represents a covalent and a site specific SMYD3 binder capable of potent and prolonged attenuation of methyltransferase activity.
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| 44. |
- Parnigoni, Arianna, et al.
(författare)
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The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism
- 2022
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Ingår i: Matrix Biology. - : Elsevier. - 0945-053X .- 1569-1802. ; 109, s. 140-161
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Tidskriftsartikel (refereegranskat)abstract
- Hyaluronan (HA) is a ubiquitous extracellular matrix component playing a crucial role in the regulation of cell behaviors, including cancer. Aggressive breast cancer cells tend to proliferate, migrate and metastatize. Notably, triple-negative breast cancer cells lacking the expression of estrogen receptor (ER) as well as progesterone receptor and HER2 are more aggressive than ER-positive ones. As currently no targeted therapy is available for triple-negative breast cancer, the identification of novel therapeutic targets has a high clinical priority. In ER-negative cells, tumoral behavior can be reduced by inhibiting HA synthesis or silencing the enzymes involved in its metabolism, such as HA synthase 2 (HAS2). HAS2-AS1 is a long non-coding RNA belonging to the natural antisense transcript family which is known to favor HAS2 gene expression and HA synthesis, thus bolstering malignant progression in brain, ovary, and lung tumors. As the role of HAS2-AS1 has not yet been investigated in breast cancer, in this work we report that ER-positive breast cancers had lower HAS2-AS1 expression compared to ER-negative tumors. Moreover, the survival of patients with ERnegative tumors was higher when the expression of HAS2-AS1 was elevated. Experiments with ER-negative cell lines as MDA-MB-231 and Hs 578T revealed that the overexpression of either the full-length HAS2-AS1 or its exon 2 long or short isoforms alone, strongly reduced cell viability, migration, and invasion, whereas HAS2-AS1 silencing increased cell aggressiveness. Unexpectedly, in these ER-negative cell lines, HAS2AS1 is involved neither in the regulation of HAS2 nor in HA deposition. Finally, transcriptome analysis revealed that HAS2-AS1 modulation affected several pathways, including apoptosis, proliferation, motility, adhesion, epithelial to mesenchymal transition, and signaling, describing this long non-coding RNA as an important regulator of breast cancer cells aggressiveness.
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| 45. |
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| 46. |
- Richardson, Henry S., et al.
(författare)
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Social Progress : A compass
- 2018
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Ingår i: Rethinking Society for the 21st Century: Report of the International Panel on Social Progress. - : Cambridge University Press. - 9781108399623 ; , s. 41-80
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter sets out the main normative dimensions that should be used in assessing whether societies have made social progress and whether a given set of proposals is likely to bring progress. Some of these dimensions are values, bearing in the first instance on the evaluation of states of affairs; others are action-guiding principles. Values can inspire and in that sense also guide actions. Principles aim to offer more specific guidance on how to rank, distribute, and realize values. Recognizing a multiplicity of values and principles is important not only to being respectful of the variety of reasonable views about what matters but also because it is difficult to reduce the list of dimensions that ultimately matter to a shorter one in a way that reflects all aspects of the phenomena in question. Many of the chapters that follow will explicitly address only a subset of these values and principles: the ones most salient for their issues or areas; but in principle, all remain relevant.
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| 47. |
- Talibov, Vladimir O., 1991-, et al.
(författare)
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Biophysical approach reveals a novel allosteric ligand binding site of SMYD3 histone methyltransferase
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- SET-and MYND-domain containing protein 3 (SMYD3) is a lysine methyltransferase that plays a role in epigenetic regulation. The protein was shown to have cancerogenic activities and is considered to be a perspective drug target. Here, we propose a Surface Plasmon Resonance-based (SPR) biophysical platform to aid SMYD3 drug discovery. The SPR screening assay was validated with a small subset of drug-like compounds, and resulted in an assay hit. The hit compound-SMYD3 complex structure was solved, and a new allosteric ligand binding site of the protein was revealed. The interaction was found localized within the previously reported SMYD3-heat shock protein 90 (HSP90) recognition site, thereby rendering the hit compound as a perspective candidate for a development of a protein-protein interface inhibitor.
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| 48. |
- Talibov, Vladimir O, 1991-, et al.
(författare)
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Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
- 2021
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Ingår i: ChemBioChem. - : Wiley. - 1439-4227 .- 1439-7633. ; 22:9, s. 1597-1608
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Tidskriftsartikel (refereegranskat)abstract
- SMYD3 is a multifunctional epigenetic enzyme with lysine methyl transferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened using a biosensor-based competition assay. Diperodon was identified as an allosteric ligand. The ( R )-and ( S )-enantiomers of the racemic drug were isolated and their affinities determined ( K D > = 42 and 84 ÎŒM). Co-crystallization revealed that both enantiomers bind to a previously unidentified allosteric site in the C-terminal protein binding domain, consistent with its weak inhibitory effect. No competition between diperodon and HSP90 (a known SMYD3 interaction partner) was observed although HSP90-SMYD3 binding was confirmed ( K D = 13 ÎŒM). The allosteric site appears to be druggable and suitable for exploration of non-catalytic SMYD3 functions and therapeutics with new mechanisms of action.
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| 49. |
- Thelin, Martin, et al.
(författare)
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate.
- 2013
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Ingår i: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 280:10, s. 2431-2446
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Forskningsöversikt (refereegranskat)abstract
- The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. During pathological conditions such as wound healing, inflammation and cancer iduronic acid has diverse regulatory functions. Iduronic acid is formed by the two epimerases DS-epimerase 1 and DS-epimerase 2 which have different tissue distribution and properties. The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. Future direction of research is to understand the roles of the two epimerases and their interplay with sulfotransferases involved in CS/DS biosynthesis. Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. In this review, we focus on the two enzymes responsible for iduronic acid formation and the role of iduronic acid in health and disease. © 2013 The Authors Journal compilation © 2013 FEBS.
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