| 1. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 2. |
- Bongi, M, et al.
(författare)
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PAMELA : A satellite experiment for antiparticles measurement in cosmic rays
- 2004
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Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 51:3, s. 854-859
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Tidskriftsartikel (refereegranskat)abstract
- PAMELA is a satellite-borne experiment that will study the antiproton and positron fluxes in cosmic rays in a wide range of energy (from 80 MeV up to 190 GeV for antiprotons and from 50 MeV up to 270 GeV for positrons) and with high statistics, and that will measure the antihelium/helium ratio with a sensitivity of the order of 10(-8). The detector will fly on-board a polar orbiting Resurs DK1 satellite, which will be launched into space by a Soyuz rocket in 2004 from Baikonur cosmodrome in Kazakhstan, for a 3-year-long mission. Particle identification and energy measurements are performed in the PAMELA apparatus using the following subdetectors: a magnetic spectrometer made up of a permanent magnet equipped with double-sided microstrip silicon detectors, an electromagnetic imaging calorimeter composed of layers of tungsten absorber and silicon detectors planes, a transition radiation detector made of straw tubes interleaved with carbon fiber radiators, a plastic scintillator time-of-flight and trigger system, a set of anticounter plastic scintillator detectors, and a neutron detector. The features of the detectors and the main results obtained in beam test sessions are presented.
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| 3. |
- Galper, A. M., et al.
(författare)
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International Russian-Italian mission "Rim-Pamela
- 2009
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Ingår i: Proceedings of the 13th Lomonosov Conference on Elementary Particle Physics. - : WORLD SCIENTIFIC. - 9812837582 - 9789812837585 ; , s. 199-206
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Konferensbidrag (refereegranskat)abstract
- The successful launch of spacecraft "RESURS DK" 1 with precision magnetic spectrometer "PAMELA" onboard was executed at Baikonur cosmodrome 15 June 2006. The primary phase of realization of International Russian-Italian Project "RIM-PAMELA" with German and Swedish scientists' participation has begun since the launch of instrument "PAMELA" that has mainly been directed to investigate the fluxes of galactic cosmic rays. This report contains the main scientific Project's tasks and the conditions of science program's implementation after one year since exploration has commenced.
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| 4. |
- Adriani, O., et al.
(författare)
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The PAMELA space mission
- 2008
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Ingår i: Astroparticle, Part. Space Phys., Detect. Med. Phys. Appl. - Proc. Conf.. - : WORLD SCIENTIFIC. - 9812819088 - 9789812819086 ; , s. 858-864
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Konferensbidrag (refereegranskat)abstract
- The PAMELA (a Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics) experiment, is a satellite-borne particle spectrometer. It was launched on 15th June 2006 from the Baikonur cosmodrome in Kazakhstan, is installed into the Russian Resurs-DK1 satellite. PAMELA is composed of a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. Among the PAMELA major objectives are the study of charged particles in the cosmic radiation, the investigation of the nature of dark matter, by mean of the measure of the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved. PAMELA has been in a nearly continuous data taking mode since llth July 2006. The status of the apparatus and performances will be presented.
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| 5. |
- Boezio, M., et al.
(författare)
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The first year in orbit of the pamela experiment
- 2007
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Ingår i: Proceedings of the 30th International Cosmic Ray Conference, ICRC 2007. - : Universidad Nacional Autonoma de Mexico. ; , s. 99-102
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Konferensbidrag (refereegranskat)abstract
- On the 15th of June 2006, the PAMELA experiment mounted on the Resurs DK1 satellite, was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. PAMELA is a satellite-borne apparatus designed to study charged particles in the cosmic radiation, to investigate the nature of dark matter, measuring the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved, and to search for antinuclei with unprecedented sensitivity. The PAMELA apparatus comprises a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. We will present the status of the apparatus after one year in orbit. Furthermore, we will discuss the PAMELA in-flight performances.
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| 6. |
- Boezio, M., et al.
(författare)
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The PAMELA space experiment : First year of operation
- 2008
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Ingår i: Journal of Physics, Conference Series. - : Institute of Physics Publishing (IOPP). - 1742-6588 .- 1742-6596. ; 110:6
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Tidskriftsartikel (refereegranskat)abstract
- On the 15th of June 2006 the PAMELA experiment, mounted on the Resurs DK1 satellite, was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. PAMELA is a satellite-borne apparatus designed to study charged particles in the cosmic radiation, to investigate the nature of dark matter, measuring the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved, and to search for antinuclei with unprecedented sensitivity. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows charged particle identification over a wide energy range. © 2008 IOP Publishing Ltd.
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| 7. |
- Casolino, M., et al.
(författare)
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Cosmic-ray observations of the heliosphere with the PAMELA experiment
- 2006
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Ingår i: Astrophysics. - : Elsevier BV. ; , s. 1848-1852
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Konferensbidrag (refereegranskat)abstract
- The PAMELA experiment is a multi-purpose apparatus built around a permanent magnet spectrometer, with the main goal of studying in detail the antiparticle component of cosmic rays. The apparatus will be carried in space by means of a Russian satellite, due to launch in 2005, for a three year-long mission. The characteristics of the detectors composing the instrument, alongside the long lifetime of the mission and the orbital characteristics of the satellite, will allow to address several items of cosmic-ray physics. In this paper, we will focus on the solar and heliospheric observation capabilities of PAMELA.
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| 8. |
- Casolino, M., et al.
(författare)
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Magnetospheric and solar physics observations with the PAMELA experiment
- 2008
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 588:1-2, s. 243-246
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Tidskriftsartikel (refereegranskat)abstract
- PAMELA is a satellite-borne experiment designed to make long duration measurements of the cosmic radiation in Low Earth Orbit. It is devoted to the detection of the cosmic-ray spectra in the 100 MeV-300 GeV range with primary scientific goal the measurement of antiproton and positron spectra over the largest energy range ever achieved. Other tasks include the search for antinuclei with unprecedented sensitivity and the measurement of the light nuclear component of cosmic rays. In addition, PAMELA can investigate phenomena connected with solar and Earth physics. The apparatus consists of: a Time of Flight system, a magnetic spectrometer, an electromagnetic imaging calorimeter, a shower tail catcher scintillator, a neutron detector and an anticoincidence system. In this work we present some measurements of galactic, secondary and trapped particles performed in the first months of operation.
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| 9. |
- Papini, P., et al.
(författare)
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In-flight performances of the PAMELA satellite experiment
- 2008
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 588:1-2, s. 259-266
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Tidskriftsartikel (refereegranskat)abstract
- PAMELA is a satcllite-borne experiment designed to study with great accuracy charged particles in the cosmic radiation with a particular focus on antiparticles. The experiment, housed on board the Russian Resurs-DK1 satellite, was launched on June 15, 2006 in a 350 x 600 km orbit with an inclination of 70 degrees. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows charged particle identification over a wide energy range. In this work, the detector design is reviewed and the in-orbit performances in the first months after the launch are presented.
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| 10. |
- Pearce, Mark, et al.
(författare)
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PAMELA : a payload for antimatter matter exploration and light-nuclei astrophysics - status and first results
- 2007
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Ingår i: 2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11. - 9781424409228 ; , s. 42-47
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Konferensbidrag (refereegranskat)abstract
- PAMELA is a satellite-borne experiment designed for precision studies of the charged cosmic radiation. The primary scientific goal is the study of the antimatter component of the cosmic radiation (antiprotons, 80 MeV - 190 GeV; and positrons, 50 MeV - 270 GeV) in order to search for evidence of dark matter particle annihilations. PAMELA will also search for primordial antinuclei (in particular, anti-helium), and test cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and studies of light nuclei and their isotopes. Concomitant goals include a study of solar physics and solar modulation during the 24th solar minimum by investigating low energy particles in the cosmic radiation; and a reconstruction of the cosmic ray electron energy spectrum up to several TeV thereby allowing a possible contribution from local sources to be studied. PAMELA is housed on-board the Russian Resurs-DK1 satellite, which was launched on June 15th 2006 in an elliptical (350-600 km altitude) orbit with an inclination of 70 degrees. PAMELA consists of a permanent magnet spectrometer, to provide rigidity and charge sign information; a Time-of-Flight and trigger system, for velocity and charge determination; a silicon-tungsten calorimeter, for lepton/hadron discrimination; and a neutron detector. An anticoincidence system is used offline to reject false triggers. In this article the PAMELA experiment and its status are reviewed. A preliminary discussion of data recorded in-orbit is also presented.
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| 11. |
- Stozhkov, Y. I., et al.
(författare)
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About Separation of Hadron and Electromagnetic Cascades in the Pamela Calorimeter
- 2005
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Ingår i: International Journal of Modern Physics A. - 0217-751X .- 1793-656X. ; 20:29, s. 6745-6748
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Tidskriftsartikel (refereegranskat)abstract
- Results of calibration of the PAMELA instrument at the CERN facilities are discussed. In September, 2003, the calibration of the Neutron Detector together with the Calorimeter was performed with the CERN beams of electrons and protons with energies of 20-180 GeV. The implementation of the Neutron Detector increases a rejection factor of hadrons from electrons about ten times. The results of calibration are in agreement with calculations.
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| 12. |
- Casolino, M., et al.
(författare)
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Launch of the space experiment PAMELA
- 2008
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Ingår i: Advances in Space Research. - : Elsevier. - 0273-1177 .- 1879-1948. ; 42:3, s. 455-466
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Tidskriftsartikel (refereegranskat)abstract
- PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature in a wide energy range (protons 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50 MeV-270 GeV) and search for antimatter with a precision of the order of 10-8. The experiment, housed on board the Russian Resurs-DK I satellite, was launched on June 15th, 2006 in a 350 x 600 km orbit with all inclination of 70'. The detector is composed of a series of scintillator counters arranged at the extremities of a permanent magnet spectrometer to provide charge, time-of-flight, and rigidity information. Lepton/hadron identification is performed by a silicon-tungsten calorimeter and a neutron detector placed at the bottom of the device. An anticounter system is used offline to reject false triggers coming from the satellite. In self-trigger mode the calorimeter, the neutron detector, and a shower tail catcher are capable of an independent measure of the lepton component up to 2 TeV. In this work we describe the experiment, its scientific objectives, and the performance in the first months after launch.
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| 13. |
- Biskup, E, et al.
(författare)
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Awareness of sex and gender dimensions among physicians: the European federation of internal medicine assessment of gender differences in Europe (EFIM-IMAGINE) survey
- 2022
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Ingår i: Internal and emergency medicine. - : Springer Science and Business Media LLC. - 1970-9366 .- 1828-0447. ; 17:5, s. 1395-1404
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Tidskriftsartikel (refereegranskat)abstract
- Sociocultural gender is a complex construct encompassing different aspects of individuals’ life, whereas sex refers to biological factors. These terms are often misused, although they impact differently on individuals’ health. Recognizing the role of sex and gender on health status is fundamental in the pursuit of a personalized medicine. Aim of the current study was to investigate the awareness in approaching clinical and research questions on the impact of sex and gender on health among European internists. Clinicians affiliated with the European Federation of Internal Medicine from 33 countries participated to the study on a voluntary basis between January 1st, 2018 and July 31st, 2019. Internists’ awareness and knowledge on sex and gender issues in clinical medicine were measured by an online anonymized 7-item survey. A total of 1323 European internists responded to the survey of which 57% were women, mostly young or middle-aged (78%), and practicing in public general medicine services (74.5%). The majority (79%) recognized that sex and gender are not interchangeable terms, though a wide discrepancy exists on what clinicians think sex and gender concepts incorporate. Biological sex and sociocultural gender were recognized as determinants of health mainly in cardiovascular and autoimmune/rheumatic diseases. Up to 80% of respondents acknowledged the low participation of female individuals in trials and more than 60% the lack of sex-specific clinical guidelines. Internists also express the willingness of getting more knowledge on the impact of sex and gender in cerebrovascular/cognitive and inflammatory bowel diseases. Biological sex and sociocultural gender are factors influencing health and disease. Although awareness and knowledge remain suboptimal across European internists, most acknowledge the underrepresentation of female subjects in trials, the lack of sex-specific guidelines and the need of being more informed on sex and gender-based differences in diseases.
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| 14. |
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| 15. |
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| 16. |
- Del Padre, M., et al.
(författare)
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Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21(low) B cells in hepatitis C virus-cured mixed cryoglobulinemia
- 2023
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Ingår i: FRONTIERS IN IMMUNOLOGY. - : Frontiers Media SA. - 1664-3224. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionHepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phenotype and functional exhaustion evidenced by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) stimuli. Although antiviral therapy is effective on MC vasculitis, pathogenic B cell clones persist long thereafter and can cause virus-independent disease relapses. MethodsClonal B cells from patients with HCV-associated type 2 MC or healthy donors were stimulated with CpG or heath-aggregated IgG (as surrogate immune complexes) alone or in combination; proliferation and differentiation were then evaluated by flow cytometry. Phosphorylation of AKT and of the p65 NF-kB subunit were measured by flow cytometry. TLR9 was quantified by qPCR and by intracellular flow cytometry, and MyD88 isoforms were analyzed using RT-PCR. DiscussionWe found that dual triggering with autoantigen and CpG restored the capacity of exhausted VH1-69pos B cells to proliferate. The signaling mechanism for this BCR/TLR9 crosstalk remains elusive, since TLR9 mRNA and protein as well as MyD88 mRNA were normally expressed and CpG-induced phosphorylation of p65 NF-kB was intact in MC clonal B cells, whereas BCR-induced p65 NF-kB phosphorylation was impaired and PI3K/Akt signaling was intact. Our findings indicate that autoantigen and CpG of microbial or cellular origin may unite to foster persistence of pathogenic RF B cells in HCV-cured MC patients. BCR/TLR9 crosstalk might represent a more general mechanism enhancing systemic autoimmunity by the rescue of exhausted autoreactive CD21low B cells.
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| 17. |
- Di Giunta, Laura, et al.
(författare)
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Longitudinal associations between mothers' and fathers' anger/irritability expressiveness, harsh parenting, and adolescents' socioemotional functioning in nine countries.
- 2020
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Ingår i: Developmental Psychology. - : American Psychological Association (APA). - 0012-1649 .- 1939-0599. ; 56:3, s. 458-474
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Tidskriftsartikel (refereegranskat)abstract
- The present study examines parents' self-efficacy about anger regulation and irritability as predictors of harsh parenting and adolescent children's irritability (i.e., mediators), which in turn were examined as predictors of adolescents' externalizing and internalizing problems. Mothers, fathers, and adolescents (N = 1,298 families) from 12 cultural groups in 9 countries (China, Colombia, Italy, Jordan, Kenya, Philippines, Sweden, Thailand, and United States) were interviewed when children were about 13 years old and again 1 and 2 years later. Models were examined separately for mothers and fathers. Overall, cross-cultural similarities emerged in the associations of both mothers' and fathers' irritability, as well as of mothers' self-efficacy about anger regulation, with subsequent maternal harsh parenting and adolescent irritability, and in the associations of the latter variables with adolescents' internalizing and externalizing problems. The findings suggest that processes linking mothers' and fathers' emotion socialization and emotionality in diverse cultures to adolescent problem behaviors are somewhat similar.
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