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| 3. |
- Aad, G., et al.
(författare)
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Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 875-916
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS detector at the Large Hadron Collider has collected several hundred million cosmic ray events during 2008 and 2009. These data were used to commission the Muon Spectrometer and to study the performance of the trigger and tracking chambers, their alignment, the detector control system, the data acquisition and the analysis programs. We present the performance in the relevant parameters that determine the quality of the muon measurement. We discuss the single element efficiency, resolution and noise rates, the calibration method of the detector response and of the alignment system, the track reconstruction efficiency and the momentum measurement. The results show that the detector is close to the design performance and that the Muon Spectrometer is ready to detect muons produced in high energy proton-proton collisions.
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| 19. |
- Aad, G., et al.
(författare)
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Readiness of the ATLAS Tile Calorimeter for LHC collisions
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:4, s. 1193-1236
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Tidskriftsartikel (refereegranskat)abstract
- The Tile hadronic calorimeter of the ATLAS detector has undergone extensive testing in the experimental hall since its installation in late 2005. The readout, control and calibration systems have been fully operational since 2007 and the detector has successfully collected data from the LHC single beams in 2008 and first collisions in 2009. This paper gives an overview of the Tile Calorimeter performance as measured using random triggers, calibration data, data from cosmic ray muons and single beam data. The detector operation status, noise characteristics and performance of the calibration systems are presented, as well as the validation of the timing and energy calibration carried out with minimum ionising cosmic ray muons data. The calibration systems' precision is well below the design value of 1%. The determination of the global energy scale was performed with an uncertainty of 4%.
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| 31. |
- Aad, G., et al.
(författare)
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Studies of the performance of the ATLAS detector using cosmic-ray muons
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:3
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Tidskriftsartikel (refereegranskat)abstract
- Muons from cosmic-ray interactions in the atmosphere provide a high-statistics source of particles that can be used to study the performance and calibration of the ATLAS detector. Cosmic-ray muons can penetrate to the cavern and deposit energy in all detector subsystems. Such events have played an important role in the commissioning of the detector since the start of the installation phase in 2005 and were particularly important for understanding the detector performance in the time prior to the arrival of the first LHC beams. Global cosmic-ray runs were undertaken in both 2008 and 2009 and these data have been used through to the early phases of collision data-taking as a tool for calibration, alignment and detector monitoring. These large datasets have also been used for detector performance studies, including investigations that rely on the combined performance of different subsystems. This paper presents the results of performance studies related to combined tracking, lepton identification and the reconstruction of jets and missing transverse energy. Results are compared to expectations based on a cosmic-ray event generator and a full simulation of the detector response.
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- Aad, G., et al.
(författare)
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The ATLAS Inner Detector commissioning and calibration
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 787-821
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 mu m and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks.
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| 37. |
- Aad, G., et al.
(författare)
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The ATLAS Simulation Infrastructure
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 823-874
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Tidskriftsartikel (refereegranskat)abstract
- The simulation software for the ATLAS Experiment at the Large Hadron Collider is being used for large-scale production of events on the LHC Computing Grid. This simulation requires many components, from the generators that simulate particle collisions, through packages simulating the response of the various detectors and triggers. All of these components come together under the ATLAS simulation infrastructure. In this paper, that infrastructure is discussed, including that supporting the detector description, interfacing the event generation, and combining the GEANT4 simulation of the response of the individual detectors. Also described are the tools allowing the software validation, performance testing, and the validation of the simulated output against known physics processes.
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| 38. |
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| 39. |
- Bauer, Brigitte, 1978, et al.
(författare)
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Modification and expulsion of keratins by human epidermal keratinocytes upon hapten exposure in vitro.
- 2011
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Ingår i: Chemical research in toxicology. - : American Chemical Society (ACS). - 1520-5010 .- 0893-228X. ; 24:5, s. 737-43
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Tidskriftsartikel (refereegranskat)abstract
- Allergic contact dermatitis is the most prevalent form of human immunotoxicity. It is caused by reactive low molecular weight chemicals, that is, haptens, coming in contact with the skin where hapten-peptide complexes are formed, activating the immune system. By using sensitizing fluorescent thiol-reactive haptens, that is, bromobimanes, we show how keratinocytes respond to hapten exposure in vitro and reveal, for the first time in a living system, an exact site of haptenation. Rapid internalization and reaction of haptens with keratin filaments were visualized. Subsequently, keratinocytes respond in vitro to hapten exposure by release of membrane blebs, which contain haptenated keratins 5 and 14. Particularly, cysteine 54 of K5 was found to be a specific target. A mechanism is proposed where neoepitopes, otherwise hidden from the immune system, are released after hapten exposure via keratinocyte blebbing. The observed expulsion of modified keratins by keratinocytes in vitro might play a role during hapten sensitization in vivo and should be subject to further investigations.
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| 40. |
- Bauer, Simon, et al.
(författare)
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A Culturally Relevant Education? Analysing “Swedish Values”in Civic Orientation for Newly Arrived Migrants
- 2024
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Ingår i: Educare - Vetenskapliga skrifter. - 1653-1868. ; :1, s. 112-144
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Tidskriftsartikel (refereegranskat)abstract
- This article contributes to ongoing discussions on education for migrants as a form of integration policy and practice. It does so by investigating whether the initiative Civic Orientation for Newly Arrived Migrants in Sweden constitutes an example of culturally relevant education. Drawing on a mixed-method and multi-level analysis, we hone in on “values” as a discursive construction in order to see how particular principles are linked to Swedishness. Specifically, we show how values are discursively constructed on multiple levels through 1) a qualitative analysis of policy documents instrumental to the implementation of civic orientation; 2) a quantitative corpus-assisted critical discourse analysis of media articles; 3) individual interviews with 14 persons involved in organizing the civic orientation courses; and 4) ethnographic classroom observations from six such courses. Our results show how, on the one hand, Sweden is constructed as the most developed country in the world in terms of values and, on the other hand, migrants are portrayed as antithetical to such an ideal imagination. Furthermore, we show how a specific set of values – human rights and democracy – changes meaning from being universal to becoming particularized and nationalized as “Swedish”.
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| 41. |
- Bauer, Simon, et al.
(författare)
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Constructing the “Good Citizen”: Discourses of Social Inclusion in Swedish Civic Orientation
- 2023
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Ingår i: Social Inclusion. - 2183-2803. ; 11:4, s. 121-131
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Tidskriftsartikel (refereegranskat)abstract
- Sweden has long been described as a beacon of multiculturalism and generous access to citizenship, with integration policies that seek to offer free and equal access to the welfare state. In this article, we use the policy of Civic Orientation for Newly Arrived Migrants as a case with which to understand how migrants’ inclusion is discursively articulated and constructed by the different constituencies involved in interpreting the policy and organising and teaching the course. We do this by employing Foucault’s closely interrelated concepts of technology of self, political technology of individuals, and governmentality. With the help of critical discourse analysis, we illustrate how migrants’ inclusion is framed around an opposition between an idealised “good citizen” and a “target population” (Schneider & Ingram, 1993). In our analysis, we draw on individual interviews with 14 people involved in organising civic orientation and on classroom observations of six civic orientation courses. Firstly, we show how migrants are constructed as unknowing and in need of being fostered by the state. Secondly, we illustrate how social inclusion is presented as being dependent upon labour market participation, both in terms of finding work and in terms of behaving correctly in the workplace. Lastly, we show how migrant women are constructed as being problematically chained to the home and therefore needing to subject themselves to a specific political technology of self to be included.
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| 42. |
- Bauer, Simon, et al.
(författare)
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Gender equality in the name of the state: state feminism or femonationalism in civic orientation for newly arrived migrants in Sweden?
- 2023
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Ingår i: Critical Discourse Studies. - 1740-5904 .- 1740-5912.
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Tidskriftsartikel (refereegranskat)abstract
- This article contributes to ongoing discussions in the social sciences about how to interpret the incorporation of gender equality into integration policies – is it a form of state feminism or femonationalism? Drawing upon intersectionality, we analyse how gender equality is presented, discussed and negotiated in relation to ethnicity and nationality in Sweden. Methodologically, we employ a bifocal lens that combines (1) a quantitative investigation of representations of civic orientation programmes in Swedish policy documents and mainstream media, and (2) a qualitative analysis of ethnographic data collected in six civic orientation courses – three in English and three in Arabic – in three large municipalities. Such a two-pronged approach, which connects policy and media discourses with interactions in civic orientation classes, offers a granular picture of the complex and often ambivalent intersections of ethnicity and gender in relation to migration in Sweden. Ultimately, the co-optation of feminist values brings with it the risk of warping feminism into a trait of national/ethnic distinctiveness. Crucially, femonationalism is not the prerogative of far-right parties but is already becoming institutionalised, informing both mainstream media and educational practices in a feminist state like Sweden.
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| 43. |
- Bauer, Simon, et al.
(författare)
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Locating Sweden in Time and Space: National Chronotopes in Civic Orientation for Adult Migrants
- 2023
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Ingår i: Nordic Journal of Migration Research. - : Helsinki University Press. - 1799-649X. ; 13:1, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to use courses in civic orientation for newly arrived adult migrants in Sweden as the empirical entry point from which to investigate whether, and if so, how, civic values are tied to the Swedish nation through specific discourses and narratives. With the help of a framework that brings together theorisations of the discursive construction of the nation with the notions of the chronotope and ‘social narratives’, the article demonstrates how narratives within civic orientation are characterised by specific spatio-temporal moves that discursively construct Sweden as a nation-state. Such national chronotopes are not innocuous but are part of a rhetoric of nationalism that constructs a linear and comprehensive story of prosperity and superiority, not least vis-à-vis some other geographical areas in the world. As such, the analysis seeks to contribute to the burgeoning scholarship on civic orientation programmes by offering further empirical evidence of the shapes such programmes take, and how civic values become nationalised. With the help of the notion of the chronotope, the article also seeks to add some fresh perspectives to scholarship on nationalism and othering by showing mundane spatio-temporal moves in the production of a ‘national imaginary’ (Calhoun 2017).
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| 44. |
- Bode, Felix J., et al.
(författare)
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Sex differences in a transgenic rat model of Huntington's disease: decreased 17 beta-estradiol levels correlate with reduced numbers of DARPP32(+) neurons in males
- 2008
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 17:17, s. 2595-2609
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Tidskriftsartikel (refereegranskat)abstract
- Recent clinical studies have highlighted that female sex hormones represent potential neuroprotective mediators against damage caused by acute and chronic brain diseases. This evidence has been confirmed by experimental studies documenting the protective role of female sex hormones both in vitro and in vivo, although these studies did not specifically focus on Huntington's disease (HD). We therefore investigated the onset and course of HD in female and male transgenic (tg) HD (CAG(n51)) and control rats across age and focused on three aspects: (i) behavioral and physiological alterations (energy expenditure, home-cage activity, emotional disturbance and motor dysfunction), (ii) morphological markers (numbers and characteristics of striatal DARPP32(+) medium-sized spiny neurons (MSNs) and dopamine receptor autoradiography) and (iii) peripheral sex hormone levels as well as striatal estrogen receptor expression. Independent of their sex, tgHD rats exhibited increased levels of food intake, elevated home-cage activity scores and anxiolytic-like behavior, whereas only males showed an impairment of motor function. In line with the latter finding, loss and atrophy of DARPP32(+) MSNs were apparent only in male tgHD rats. This result was associated with a decreased striatal dopamine D1 receptor density and lower plasma levels of 17 beta-estradiol at the age of 14 months. As DARPP32(+) MSNs expressed both alpha-and beta-estrogen receptors and showed a correlation between cell numbers and 17 beta-estradiol levels, our findings suggest sex-related differences in the HD phenotype pointing to a substantial neuroprotective effect of sex hormones and opening new perspectives on the therapy of HD.
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| 45. |
- Hyytiäinen, Kari, et al.
(författare)
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Provision of aquatic ecosystem services as a consequence of societal changes : The case of the Baltic Sea
- 2021
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Ingår i: Population Ecology. - 1438-3896 .- 1438-390X. ; 63:1, s. 61-74
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Tidskriftsartikel (refereegranskat)abstract
- Aquatic ecosystem services are important for human wellbeing, but they are much less studied than terrestrial ecosystem services. The objectives of this study are to broaden, itemize and exemplify the human‐nature interactions in modeling the future provision of aquatic ecosystem services. We include shared socioeconomic and representative concentration pathways, used extensively in climate research, as drivers of change for the future development of the Baltic Sea. Then we use biogeochemical and ecosystem models to demonstrate the future development of exemplary supporting, provisioning and cultural ecosystem services for two distinct combinations of regionally downscaled global climate and socioeconomic futures. According to the model simulations, the two global futures (“Sustainable well‐being” vs. “Fossil‐fuelled development”) studied lead to clearly deviating trajectories in the provision of marine ecosystem services. Under the “Sustainable well‐being”‐scenario primary production decreases by 20%, catches of demersal fish increases and the recreation opportunities increase significantly by the end of the ongoing century. Under the “fossil‐fuelled development”‐scenario primary production doubles, fisheries focus on less valued pelagic fish and the recreation possibilities will decrease. Long‐term projections of aquatic ecosystem services prepared for alternative global socioeconomic futures can be used by policy makers and managers to adaptively and iteratively adjust mitigation and adaptation effort with plausible future changes in the drivers of water pollution.
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| 46. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 47. |
- Milani, Tommaso M., 1973, et al.
(författare)
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Citizenship as status, habitus and acts: Language requirements and civic orientation in Sweden
- 2021
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Ingår i: Citizenship Studies. - : Informa UK Limited. - 1362-1025 .- 1469-3593. ; 25:6, s. 756-772
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Tidskriftsartikel (refereegranskat)abstract
- This article employs the notions of citizenship as status, habitus and acts as a framework through which to capture how sovereign power, disciplinary power and biopower intersect in the context of Sweden’s current management of migration. Through an analysis of policy and media debates, the article first illustrates how citizenship as status and sovereign power in Sweden have undergone a shift from actively endorsing multilingualism and cultural dialogue to requiring migrants to demonstrate knowledge of a particular language, Swedish, and what is constructed as a singular national culture and its values. The article then homes in on a particular Arabic-language course in civic orientation for newly arrived adult migrants in a large urban area. We illustrate how disciplinary power and biopower work by socializing a group of migrants into a specific habitus of Swedish values and norms. We also unveil the acts of resistance they perform in response.
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| 48. |
- Milani, Tommaso M., 1973, et al.
(författare)
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Participation on whose terms? Applied linguistics, politics and social justice
- 2023
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Ingår i: AFinLA Yearbook. - 2343-2608. ; 80, s. 286-299
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this position paper is to engage with the focus of this yearbook on language and participation by revisiting some of the arguments advanced by the North American political philosopher Nancy Fraser, who theorized (1) the structural components that enable and/or constrain participation, and (2) the ways in which we can transform the status quo with a view to achieving a more just society. The paper begins by outlining Fraser’s main ideas; it then moves on to illustrate how this theoretical framework may help us shed light on the dilemmas and/or pitfalls of well-meaning initiatives that seek to enhance adult migrants’ participation. The empirical focus is on courses in civic orientation (samhällsorientering) for newly arrived adult migrants in Sweden. The paper ends with some reflections about the importance of a politically engaged applied linguistics.
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| 49. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 50. |
- Siebzehnrübl, Florian A., et al.
(författare)
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Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
- 2018
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:37, s. 8765-8774
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Tidskriftsartikel (refereegranskat)abstract
- Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy remains unclear. Here, we identify very early behavioral, molecular, and cellular changes in preweaning transgenic HD rats and mice. Reduced ultrasonic vocalization, loss of prepulse inhibition, and increased risk taking are accompanied by disturbances of dopaminergic regulation in vivo, reduced neuronal differentiation capacity in subventricular zone stem/progenitor cells, and impaired neuronal and oligodendrocyte differentiation of mouse embryo-derived neural stem cells in vitro. Interventional treatment of this early phenotype with the histone deacetylase inhibitor (HDACi) LBH589 led to significant improvement in behavioral changes and markers of dopaminergic neurotransmission and complete reversal of aberrant neuronal differentiation in vitro and in vivo. Our data support the notion that neurodevelopmental changes contribute to the prodromal phase of HD and that early, presymptomatic intervention using HDACi may represent a promising novel treatment approach for HD.
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