| 1. |
- Momozawa, Y, et al.
(författare)
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IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
- 2018
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 2427-
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Tidskriftsartikel (refereegranskat)abstract
- GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach.
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| 2. |
- Dall'Ora, M., et al.
(författare)
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THE TYPE IIP SUPERNOVA 2012aw IN M95 : HYDRODYNAMICAL MODELING OF THE PHOTOSPHERIC PHASE FROM ACCURATE SPECTROPHOTOMETRIC MONITORING
- 2014
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 787:2, s. 139-
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Tidskriftsartikel (refereegranskat)abstract
- We present an extensive optical and near-infrared photometric and spectroscopic campaign of the Type IIP supernova SN 2012aw. The data set densely covers the evolution of SN 2012aw shortly after the explosion through the end of the photospheric phase, with two additional photometric observations collected during the nebular phase, to fit the radioactive tail and estimate the Ni-56 mass. Also included in our analysis is the previously published Swift UV data, therefore providing a complete view of the ultraviolet-optical-infrared evolution of the photospheric phase. On the basis of our data set, we estimate all the relevant physical parameters of SN 2012aw with our radiation-hydrodynamics code: envelope mass M-env similar to 20 M-circle dot, progenitor radius R similar to 3 x 10(13) cm (similar to 430 R-circle dot), explosion energy E similar to 1.5 foe, and initial Ni-56 mass similar to 0.06 M-circle dot. These mass and radius values are reasonably well supported by independent evolutionary models of the progenitor, and may suggest a progenitor mass higher than the observational limit of 16.5 +/- 1.5 M-circle dot of the Type IIP events.
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| 5. |
- Oates, S. R., et al.
(författare)
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Multiwavelength observations of the Type IIb supernova 2009mg
- 2012
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 424:2, s. 1297-1306
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Tidskriftsartikel (refereegranskat)abstract
- We present Swift Ultra-Violet Optical Telescope and X-Ray Telescope (XRT) observations, and visual wavelength spectroscopy of the Type IIb supernova (SN) 2009mg, discovered in the Sb galaxy ESO 121-G26. The observational properties of SN 2009mg are compared to the prototype Type IIb SNe 1993J and 2008ax, with which we find many similarities. However, minor differences are discernible including SN 2009mg not exhibiting an initial fast decline or u-band upturn as observed in the comparison objects, and its rise to maximum is somewhat slower leading to slightly broader light curves. The late-time temporal index of SN 2009mg, determined from 40 d post-explosion, is consistent with the decay rate of SN 1993J, but inconsistent with the decay of 56Co. This suggests leakage of ?-rays out of the ejecta and a stellar mass on the small side of the mass distribution. Our XRT non-detection provides an upper limit on the mass-loss rate of the progenitor of . Modelling of the SN light curve indicates a kinetic energy of , an ejecta mass of and a 56Ni mass of 0.10 +/- 0.01 M?.
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| 6. |
- Franke, Andre, et al.
(författare)
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1118-1125
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Tidskriftsartikel (refereegranskat)abstract
- We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
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