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Sökning: WFRF:(Becker Dirk)

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1.
  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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2.
  • Satizabal, Claudia L., et al. (författare)
  • Genetic architecture of subcortical brain structures in 38,851 individuals
  • 2019
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
  • Tidskriftsartikel (refereegranskat)abstract
    • Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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3.
  • Schuette, Moritz, et al. (författare)
  • Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.
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4.
  • Abbasi, Rasha, et al. (författare)
  • IceCube search for neutrinos from GRB 221009A
  • 2023
  • Ingår i: Proceedings of 38th International Cosmic Ray Conference (ICRC 2023). - : Sissa Medialab Srl.
  • Konferensbidrag (refereegranskat)abstract
    •  GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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5.
  • Algora, A., et al. (författare)
  • Pronounced Shape Change Induced by Quasiparticle Alignment
  • 2000
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 61:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Mean lifetimes of high-spin states of Kr-74 have been determined using the Doppler-shift attenuation method. The high-spin states were studied using the Ca-40(Ca-40, alpha 2p) reaction at a beam energy of 160 MeV with the GASP gamma-ray spectrometer. The ground-state band and negative parity side band show the presence of three different configurations in terms of transitional quadrupole deformations. A dramatic shape change was found along the ground-state band after the S-band crossing. The deduced quadrupole deformation changes are well reproduced by cranked Woods-Saxon Strutinsky calculations.
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6.
  • Atanasova, L., et al. (författare)
  • g-factor Measurements at RISING: The Cases of 127Sn and 128Sn
  • 2010
  • Ingår i: Europhysics Letters. - : IOP Publishing. - 0295-5075. ; 91:4
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on g-factor measurements of the 19/2(+) T-1/2 = 4.5(3) mu s isomer in Sn-127 and the 10(+) T-1/2 = 2.69(23) mu s isomer in Sn-128. These isomers were produced and spin-aligned in relativistic heavy-ion fragmentation at GSI and were selected and separated by the GSI fragment separator ( FRS). The gamma-rays of the isomeric decay were detected by the RISING gamma-ray spectrometer. The method of time-differential perturbed angular distributions was utilized. The measured g-factors, g(19/2(+); Sn-127) =-0.17(2) and g(10(+); Sn-128)=-0.20(4), are compared with shell model calculations. The measured g-factors confirm the predominantly nu h(11/2)(-2) and nu(s(1/2)(-1) h(11/2)(-2)) character of the 10(+) and 19/2(-) isomers in Sn-128 and Sn-127, respectively. The results demonstrate the feasibility of the method for similar measurements in exotic neutron-rich nuclei. Copyright (C) EPLA, 2010
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7.
  • Banu, A, et al. (författare)
  • 108Sn Studied with Intermediate-energy Coulomb Excitation
  • 2005
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 72:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The unstable neutron-deficient Sn-108 isotope has been studied in inverse kinematics by intermediate-energy Coulomb excitation using the RISING/FRS experimental setup at GSI. This is the highest Z nucleus studied so far with this method. Its reduced transition probability B (E2;0(g.s.)(+)-> 2(1)(+)) has been measured for the first time. The extracted B(E2) value of 0.230(57)e(2) b(2) has been determined relative to the known value in the stable Sn-112 isotope. The result is discussed in the framework of recent large-scale shell model calculations performed with realistic effective interactions. The roles of particle-hole excitations of the Sn-100 core and of the Z=50 shell gap for the E2 polarization are investigated.
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8.
  • Beal, Jacob, et al. (författare)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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9.
  • Becker, F, et al. (författare)
  • Status of the RISING Project at GSI
  • 2005
  • Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 25:Suppl 1, s. 719-722
  • Tidskriftsartikel (refereegranskat)abstract
    • The FRS-RISING set-up at GSI uses secondary radioactive beams at relativistic energies for nuclear structure studies. At GSI the fragmentation or fission of stable primary beams up to U-238 provide secondary beams with sufficient intensity to perform gamma-ray spectroscopy. The RISING set-up is described and results of the first RISING campaign are presented. New experimental methods at relativistic energies are being investigated. Future experiments focus on state-of-the art nuclear structure physics covering exotic nuclei all over the nuclear chart.
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10.
  • Bednarczyk, P, et al. (författare)
  • Status of the RISING Project at Relativistic Energies
  • 2005
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 36:4, s. 1235-1244
  • Tidskriftsartikel (refereegranskat)abstract
    • The RISING project was designed to perform high-resolution gamma-ray spectroscopy with radioactive beams at GSI. Unstable beams were produced by fragmentation of relativistic heavy ion projectiles provided by the SIS synchrotron. The fragment separator FRS was used to select and to focus the exotic fragments at about 100A MeV energy on a secondary target. Various charged particle detectors enabled an event-by-event tracking of the incoming radioactive projectiles and the reaction products, thus allowing for a selection of the nuclei of interest and their velocity vector reconstruction. The gamma-ray detection system consisting of the EUROBALL Cluster Ge detectors and the large volume HECTOR BaF2 detectors measured prompt gamma-radiation from nuclei excited in the secondary target. Despite the huge Doppler shift due to the high recoil velocity (beta approximate to 40%), RISING achieved a gamma-energy resolution below 2%. The paper reviews the present status of the RISING project.
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11.
  • Caceres, L. S., et al. (författare)
  • Identification of Excited States in the N = Z Nucleus 82Nb
  • 2007
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1271-1275
  • Tidskriftsartikel (refereegranskat)abstract
    • Information on the first excited states in the N = Z = 41 nucleus Nb-82 sheds light on the competition of isospin T = 0 and T = 1 states in the A similar to 80 region. The measurement was performed at the GSI laboratory using fragmentation of a Ag-107 primary beam at 750 MeV/u on a 4 g/cm(2) Be-9 target. The fragments were separated and identified unambiguously in the FRagment Separator. Three excited states were observed and the half-life estimate for the isomeric state was extracted. A tentative spin assignment based on the isobaric analogue states systematics in the T-z = 1 nucleus Zr-82, and transition probabilities indicate T = 1 character of the first two excited states, and T = 0 for the isomeric state.
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12.
  • Doornenbal, P., et al. (författare)
  • RISING: Gamma‐ray Spectroscopy with Radioactive Beams at GSI
  • 2007
  • Ingår i: AIP Conference Proceedings. - : AIP. - 0094-243X. - 9780735413283 ; 891, s. 99-107
  • Konferensbidrag (refereegranskat)abstract
    • The Rare Isotope Spectroscopic INvestigation at GSI (RISING) project is a major pan‐European collaboration. Its physics aims are the studies of exotic nuclear matter with abnormal proton‐to‐neutron ratios compared with naturally occurring isotopes. RISING combines the FRagment Separator (FRS) which allows relativistic energies and projectile fragmentation reactions with EUROBALL Ge Cluster detectors for γ spectroscopic research. The RISING setup can be used in two different configurations. Either the nuclei of interest are investigated after being stopped or the heavy ions hit a secondary target at relativistic energies and the thereby occurring excitations are studied. For the latter case, MINIBALL Ge detectors and the HECTOR array are used in addition. Example achievements of the Fast Beam setup are presented and compared to various shell model calculations, while for the Stopped Beam setup initial results are shown.
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13.
  • Farrelly, G. F., et al. (författare)
  • Revision of the K-Isomer in 190W
  • 2009
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 40:3, s. 885-888
  • Tidskriftsartikel (refereegranskat)abstract
    • Gamma rays from the decay of an isomer in W-190(116) have been observed following projectile fragmentation of a 1 GeV per nucleon Pb-208 beam. An earlier experiment indicated decay from a (10(-)) isomer to the ground state rotational band. Improved statistics have enabled gamma coincidence and time-difference measurements to be made which alter the previous interpretation. Blocked BCS calculations have also been used together with reduced hindrance factors to indicate possible values of spin-parity for the isomer.
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14.
  • Garnsworthy, A. B., et al. (författare)
  • Isomeric States in Neutron-deficient A~80-90 Nuclei Populated in the Fragmentation of 107Ag
  • 2009
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The relativistic projectile fragmentation of a 750 MeV per nucleon beam of Ag-107 was used to populate isomeric states in neutron-deficient nuclei around A=80-90. Reaction products were separated and unambiguously identified using the GSI FRagment Separator (FRS) and its ancillary detectors. At the final focal plane, the fragments were slowed from relativistic energies by means of an aluminium degrader and implanted in a passive stopper in the center of the high-efficiency, high-granularity Stopped Rare Isotope Spectroscopic INvestigation at GSI (RISING) germanium array. This allowed the identification of excited states in the N=Z nuclei Tc-86(43) and, for the first time, Nb-82(41). Isomeric states have also been identified for the first time in Tc-87,Tc-88, and a previously unreported isomer was observed in Nb-84. Experimental results are presented along with a discussion on the structure of these nuclei based on interpretations provided by several theoretical models.
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15.
  • Garnsworthy, A. B., et al. (författare)
  • Isomeric States in the Light Tc Isotopes
  • 2007
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1265-1269
  • Tidskriftsartikel (refereegranskat)abstract
    • Preliminary results from the first experiment of the Stopped Beam RISING campaign are presented. The relativistic projectile fragmentation of a 750 MeV/u beam of Ag-107 populated isomeric states in very neutron deficient nuclei at the proton dripline around mass 80-90. Nuclei were unambiguously identified using the FRagment Separator (FRS) and its ancillary detectors located at GSI. The ions produced were slowed down from relativistic energies by means of an Al degrader and implanted in the centre of the high-efficiency Stopped RISING array. This allowed the identification of new excited states in the N = Z = 43 nucleus, Tc-86, populated following the de-excitation of a microsecond isomer. Preliminary results of this analysis, as well as previously unobserved isomeric states in Tc-87,Tc-88. are reported.
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16.
  • Garnsworthy, A B, et al. (författare)
  • Neutron-proton pairing competition in N = Z nuclei: Metastable state decays in the proton dripline nuclei Nb-82(41) and Tc-86(43)
  • 2008
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 660:4, s. 326-330
  • Tidskriftsartikel (refereegranskat)abstract
    • The low-lying structures of the self-conjugate (N = Z) nuclei Nb-82(41)41 and Tc-86(43)43 have been investigated using isomeric-decay spectroscopy following the projectile fragmentation of a Ag-107 beam. These represent the heaviest odd-odd N = Z nuclei in which internal decays have been identified to date. The resulting level schemes shed light on the shape evolution along the N = Z line between the doubly-magic systems Ni-56(28) and Sn-100(50) and support a preference for T = 1 states in T-z = 0 odd-odd nuclei at low excitation energies associated with a T = 1 neutron-proton pairing gap. Comparison with Projected Shell Model calculations suggests that the decay in Nb-82 may be interpreted as an isospin-changing K isomer.
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17.
  • Hammond, G, et al. (författare)
  • Spectroscopy of T=3/2 Mirror Nuclei via Two-step Fragmentation using RISING
  • 2005
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 36:4, s. 1253-1257
  • Tidskriftsartikel (refereegranskat)abstract
    • Two two-step fragmentation reactions were performed using RISING to populate excited states in A approximate to 50 mirror nuclei near to the proton-drip line, in order to test isospin symmetry. The experiments were designed to observe gamma decays of excited states in the mirror nuclei Ni-53(28)25/Mn-53(25)28, which have a large value of total isospin (T = 3/2). In the continuing off-line analysis, gamma transitions have been observed in Ni-54 indicating that two-step fragmentation is a successful technique for spectroscopic investigations of proton-rich nuclear systems in this mass region.
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18.
  • Hansson, Sven Ove, et al. (författare)
  • Breeding for public health : A strategy
  • 2018
  • Ingår i: Trends in Food Science & Technology. - : Elsevier. - 0924-2244 .- 1879-3053. ; 80, s. 131-140
  • Forskningsöversikt (refereegranskat)abstract
    • Background Plant and animal breeding can contribute to promote human health by providing new and healthier food products that farmers can produce in an economically viable way and consumers will choose to buy and eat. However, this can only be achieved if breeding makes full use of knowledge about nutrition, consumer behaviour, farming and agricultural economics, A strategy is needed for breeding for public health. Scope and Approach: A multidisciplinary group of researchers has developed a strategy for plant and animal breeding for public health. The group includes experts in plant breeding, animal breeding, food science, nutrition science, clinical nutrition, agricultural economics, consumer research, and ethics. Key Findings and Conclusions: An outline is proposed of a strategy for breeding for public health. It aims at improving public health in both low- and high-income countries. To prevent chronic disease, the highest priority should be to develop healthy variants of traditional food items that can be introduced universally, i.e. completely replace the older, less healthy variants. In particular in low-income countries, food products with enhanced micronutrient content are urgently needed. In all countries, crops with improved fatty acid composition can contribute substantially to improved public health. A reasonable second priority is products that may not be suitable for universal introduction but will expectedly be demanded by large groups of consumers. One example could be diminishing the energy density of traditional foodstuffs by reducing their fat, sugar, and starch content and increasing their dietary fibre content, Changes in the current organization of the market for farm products are needed to encourage the production of healthier foodstuffs.
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19.
  • Hoischen, Robert, et al. (författare)
  • Isomeric Mirror States as Probes for Effective Charges in the Lower pf Shell
  • 2011
  • Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 38:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Following the fragmentation of a 550 MeV u(-1)primary beam of Ni-58, time-and energy-correlated gamma decays from isomeric states in neutron-deficient nuclei in the 1f(7/2) shell have been identified using the GSI fragment separator in combination with the RISING Ge-detector array. The results on isomers in the mirror pairs Ti-43(22)21-Sc-43(21)22 (I-pi = 3/2(+) and 19/2(-)), Cr-45(24)21-Sc-45(21)24 (I-pi = 3/2(+)) and V-45(23)22-Ti-45(22)23 (I-pi = 3/2(-)) are discussed in the framework of large scale pf and sdpf shell-model calculations, the former in conjunction with isospin symmetry breaking effects with emphasis on effective charges.
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20.
  • Kessler, Thorsten, et al. (författare)
  • Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention
  • 2019
  • Ingår i: Cardiovascular Research. - : OXFORD UNIV PRESS. - 0008-6363 .- 1755-3245. ; 115:10, s. 1512-1518
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Methods and results The association of GUCY1A3 genotype and on-aspirin platelet reactivity was analysed in the genetics substudy of the ISAR-ASPI registry (n = 1678) using impedance aggregometry. The clinical outcome cardiovascular death or stent thrombosis within 30 days after stenting was investigated in a meta-analysis of substudies of the ISAR-ASPI registry, the PLATO trial (n = 3236), and the Utrecht Coronary Biobank (n = 1003) comprising a total 5917 patients. Homozygous GUCY1A3 risk allele carriers (GG) displayed increased on-aspirin platelet reactivity compared with non-risk allele (AA/AG) carriers [150 (interquartile range 91-209) vs. 134 (85-194) AU.min, P < 0.01]. More homozygous risk allele carriers, compared with non-risk allele carriers, were assigned to the high-risk group for ischaemic events (>203AU.min; 29.5 vs. 24.2%, P = 0.02). Homozygous risk allele carriers were also at higher risk for cardiovascular death or stent thrombosis (hazard ratio 1.70, 95% confidence interval 1.08-2.68; P = 0.02). Bleeding risk was not altered. Conclusion We conclude that homozygous GUCY1A3 risk allele carriers are at increased risk of cardiovascular death or stent thrombosis within 30 days after coronary stenting, likely due to higher on-aspirin platelet reactivity. Whether GUCY1A3 genotype helps to tailor antiplatelet treatment remains to be investigated.
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21.
  • Kmiecik, M., et al. (författare)
  • Spin-alignment and g-factor Measurement of the I=12+ Isomer in 192Pb Produced in the Relativistic-energy Fragmentation of a 238U Beam
  • 2010
  • Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 45:2, s. 153-158
  • Tidskriftsartikel (refereegranskat)abstract
    • The feasibility of measuring g-factors using the TDPAD method applied to high-energy, heavy fragmentation products is explored. The 2623 keV I-pi = 12(+) isomer in Pb-192 with tau = 1.57 mu s has been produced using the fragmentation of a 1 A GeV U-238 beam. The results presented demonstrate for the first time that such heavy nuclei produced in a fragmentation reaction with a relativistic beam are sufficiently well spin-aligned. Moreover, the rather large value of the alignment, 28(10)% of the maximum possible, is preserved during the separation process allowing the determination of magnetic moments. The measured values of the lifetime, tau = 1.54(9) mu s, and the g-factor, g = -0.175(20), agree with the results of previous investigations using fusion-evaporation reactions.
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22.
  • Kreisz, Philipp, et al. (författare)
  • S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs
  • 2024
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 121:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Plants tightly control growth of their lateral organs, which led to the concept of apical dominance. However, outgrowth of the dormant lateral primordia is sensitive to the plant's nutritional status, resulting in an immense plasticity in plant architecture. While the impact of hormonal regulation on apical dominance is well characterized, the prime importance of sugar signaling to unleash lateral organ formation has just recently emerged. Here, we aimed to identify transcriptional regulators, which control the trade-off between growth of apical versus lateral organs. Making use of locally inducible gain-of-function as well as single and higher-order loss-of-function approaches of the sugar-responsive S1-basic-leucine-zipper (S1-bZIP) transcription factors, we disclosed their largely redundant function in establishing apical growth dominance. Consistently, comprehensive phenotypical and analytical studies of S1-bZIP mutants show a clear shift of sugar and organic nitrogen (N) allocation from apical to lateral organs, coinciding with strong lateral organ outgrowth. Tissue-specific transcriptomics reveal specific clade III SWEET sugar transporters, crucial for long-distance sugar transport to apical sinks and the glutaminase GLUTAMINE AMIDO-TRANSFERASE 1_2.1, involved in N homeostasis, as direct S1-bZIP targets, linking the architectural and metabolic mutant phenotypes to downstream gene regulation. Based on these results, we propose that S1-bZIPs control carbohydrate (C) partitioning from source leaves to apical organs and tune systemic N supply to restrict lateral organ formation by C/N depletion. Knowledge of the underlying mechanisms controlling plant C/N partitioning is of pivotal importance for breeding strategies to generate plants with desired architectural and nutritional characteristics.
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23.
  • Lozeva, R. L., et al. (författare)
  • New sub-us Isomers in 125Sn, 127Sn, 129Sn and Isomer Systematics of 124-130Sn
  • 2008
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 77:6
  • Tidskriftsartikel (refereegranskat)abstract
    • New sub-mu s isomers have been observed in the neutron-rich Sn isotopes. Sn-125,Sn-127,Sn-129 nuclei have been produced in a relativistic fission reaction of U-238 on a Be-9 target at 750 A.MeV and by the fragmentation of Xe-136 at 600 A.MeV populating high-spin yrast states. In addition to the already known mu s isomers, three new ones with sub-mu s half-lives have been observed. These yrast isomers are the high-spin members of the nu(d(3/2)(-1)h(11/2)(-2)) and nu h(11/2)(-n), seniority v = 3 multiplets leading to isomeric (23/2(+)) and (27/2(-)) states, respectively. Added to the already known 19/2(+)mu s isomers in this region the current work completes the systematic information of neutron-hole excitations toward the filling of the last h(11/2) orbital at N = 82. The results are discussed in the framework of state-of-the-art shell-model calculations using realistic interactions.
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24.
  • Löw, Karin, et al. (författare)
  • Luminescent reporter cells enable the identification of broad-spectrum antivirals against emerging viruses
  • 2023
  • Ingår i: Journal of Medical Virology. - : John Wiley & Sons. - 0146-6615 .- 1096-9071. ; 95:11
  • Tidskriftsartikel (refereegranskat)abstract
    • The emerging viruses SARS-CoV-2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs). SARS-CoV-2 and arenaviruses rely on GP cleavage by PCs furin and subtilisin kexin isozyme-1/site-1 protease (SKI-1/S1P), respectively. We report improved luciferase-based reporter cell lines, named luminescent inducible proprotein convertase reporter cells that we employ to monitor PC activity in its authentic subcellular compartment. Using these sensor lines we screened a small compound library in high-throughput manner. We identified 23 FDA-approved small molecules, among them monensin which displayed broad activity against furin and SKI-1/S1P. Monensin inhibited arenaviruses and SARS-CoV-2 in a dose-dependent manner. We observed a strong reduction in infectious particle release upon monensin treatment with little effect on released genome copies. This was reflected by inhibition of SARS-CoV-2 spike processing suggesting the release of immature particles. In a proof of concept experiment using human precision cut lung slices, monensin potently inhibited SARS-CoV-2 infection, evidenced by reduced infectious particle release. We propose that our PC sensor pipeline is a suitable tool to identify broad-spectrum antivirals with therapeutic potential to combat current and future emerging viruses.
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25.
  • Mauritsen, Thorsten, et al. (författare)
  • Developments in the MPI-M Earth System Model version 1.2 (MPI-ESM1.2) and Its Response to Increasing CO2
  • 2019
  • Ingår i: Journal of Advances in Modeling Earth Systems. - 1942-2466. ; 11:4, s. 998-1038
  • Tidskriftsartikel (refereegranskat)abstract
    • A new release of the Max Planck Institute for Meteorology Earth System Model version 1.2 (MPI-ESM1.2) is presented. The development focused on correcting errors in and improving the physical processes representation, as well as improving the computational performance, versatility, and overall user friendliness. In addition to new radiation and aerosol parameterizations of the atmosphere, several relatively large, but partly compensating, coding errors in the model's cloud, convection, and turbulence parameterizations were corrected. The representation of land processes was refined by introducing a multilayer soil hydrology scheme, extending the land biogeochemistry to include the nitrogen cycle, replacing the soil and litter decomposition model and improving the representation of wildfires. The ocean biogeochemistry now represents cyanobacteria prognostically in order to capture the response of nitrogen fixation to changing climate conditions and further includes improved detritus settling and numerous other refinements. As something new, in addition to limiting drift and minimizing certain biases, the instrumental record warming was explicitly taken into account during the tuning process. To this end, a very high climate sensitivity of around 7 K caused by low-level clouds in the tropics as found in an intermediate model version was addressed, as it was not deemed possible to match observed warming otherwise. As a result, the model has a climate sensitivity to a doubling of CO2 over preindustrial conditions of 2.77 K, maintaining the previously identified highly nonlinear global mean response to increasing CO2 forcing, which nonetheless can be represented by a simple two-layer model. 
  •  
26.
  • McGrath, Matthew J., et al. (författare)
  • The consolidated European synthesis of CO2 emissions and removals for the European Union and United Kingdom : 1990-2020
  • 2023
  • Ingår i: Earth System Science Data. - 1866-3508. ; 15:10, s. 4295-4370
  • Tidskriftsartikel (refereegranskat)abstract
    • Quantification of land surface-atmosphere fluxes of carbon dioxide (CO2) and their trends and uncertainties is essential for monitoring progress of the EU27+UK bloc as it strives to meet ambitious targets determined by both international agreements and internal regulation. This study provides a consolidated synthesis of fossil sources (CO2 fossil) and natural (including formally managed ecosystems) sources and sinks over land (CO2 land) using bottom-up (BU) and top-down (TD) approaches for the European Union and United Kingdom (EU27+UK), updating earlier syntheses (Petrescu et al., 2020, 2021). Given the wide scope of the work and the variety of approaches involved, this study aims to answer essential questions identified in the previous syntheses and understand the differences between datasets, particularly for poorly characterized fluxes from managed and unmanaged ecosystems. The work integrates updated emission inventory data, process-based model results, data-driven categorical model results, and inverse modeling estimates, extending the previous period 1990-2018 to the year 2020 to the extent possible. BU and TD products are compared with the European national greenhouse gas inventory (NGHGI) reported by parties including the year 2019 under the United Nations Framework Convention on Climate Change (UNFCCC). The uncertainties of the EU27+UK NGHGI were evaluated using the standard deviation reported by the EU member states following the guidelines of the Intergovernmental Panel on Climate Change (IPCC) and harmonized by gap-filling procedures. Variation in estimates produced with other methods, such as atmospheric inversion models (TD) or spatially disaggregated inventory datasets (BU), originate from within-model uncertainty related to parameterization as well as structural differences between models. By comparing the NGHGI with other approaches, key sources of differences between estimates arise primarily in activities. System boundaries and emission categories create differences in CO2 fossil datasets, while different land use definitions for reporting emissions from land use, land use change, and forestry (LULUCF) activities result in differences for CO2 land. The latter has important consequences for atmospheric inversions, leading to inversions reporting stronger sinks in vegetation and soils than are reported by the NGHGI. For CO2 fossil emissions, after harmonizing estimates based on common activities and selecting the most recent year available for all datasets, the UNFCCC NGHGI for the EU27+UK accounts for 926g±g13gTggCgyr-1, while eight other BU sources report a mean value of 948 [937,961]gTggCgyr-1 (25th, 75th percentiles). The sole top-down inversion of fossil emissions currently available accounts for 875gTggC in this same year, a value outside the uncertainty of both the NGHGI and bottom-up ensemble estimates and for which uncertainty estimates are not currently available. For the net CO2 land fluxes, during the most recent 5-year period including the NGHGI estimates, the NGHGI accounted for -91g±g32gTggCgyr-1, while six other BU approaches reported a mean sink of -62 [-117,-49]gTggCgyr-1, and a 15-member ensemble of dynamic global vegetation models (DGVMs) reported -69 [-152,-5]gTggCgyr-1. The 5-year mean of three TD regional ensembles combined with one non-ensemble inversion of -73gTggCgyr-1 has a slightly smaller spread (0th-100th percentiles of [-135,+45]gTggCgyr-1), and it was calculated after removing net land-atmosphere CO2 fluxes caused by lateral transport of carbon (crop trade, wood trade, river transport, and net uptake from inland water bodies), resulting in increased agreement with the NGHGI and bottom-up approaches. Results at the category level (Forest Land, Cropland, Grassland) generally show good agreement between the NGHGI and category-specific models, but results for DGVMs are mixed. Overall, for both CO2 fossil and net CO2 land fluxes, we find that current independent approaches are consistent with the NGHGI at the scale of the EU27+UK. We conclude that CO2 emissions from fossil sources have decreased over the past 30 years in the EU27+UK, while land fluxes are relatively stable: positive or negative trends larger (smaller) than 0.07 (-0.61)gTggCgyr-2 can be ruled out for the NGHGI. In addition, a gap on the order of 1000gTggCgyr-1 between CO2 fossil emissions and net CO2 uptake by the land exists regardless of the type of approach (NGHGI, TD, BU), falling well outside all available estimates of uncertainties. However, uncertainties in top-down approaches to estimate CO2 fossil emissions remain uncharacterized and are likely substantial, in addition to known uncertainties in top-down estimates of the land fluxes. The data used to plot the figures are available at 10.5281/zenodo.8148461 (McGrath et al., 2023).
  •  
27.
  • Mineva, Milena, et al. (författare)
  • A New us Isomer in 136Sb Produced in the Projectile Fission of 238U
  • 2001
  • Ingår i: European Physical Journal A. Hadrons and Nuclei. - 1434-6001. ; 11, s. 9-13
  • Tidskriftsartikel (refereegranskat)abstract
    • The neutron-rich isotope Sb-136 has been produced following the relativistic projectile fission of U-238 in an experiment performed at the Fragment Separator at GSI, Darmstadt. Delayed gamma -ray spectroscopy of the fission products has been performed after isotope separation. A new isomeric state in Sb-136 has been populated, and its lifetime measured as T-1/2 = 565(50) ns. Realistic and empirical shell-model calculations have been performed and are compared to the experimental observables.
  •  
28.
  • Muralidhara, Prathibha, et al. (författare)
  • Perturbations in plant energy homeostasis prime lateral root initiation via SnRK1-bZIP63-ARF19 signaling
  • 2021
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 118:37
  • Tidskriftsartikel (refereegranskat)abstract
    • Plants adjust their energy metabolism to continuous environmental fluctuations, resulting in a tremendous plasticity in their architecture. The regulatory circuits involved, however, remain largely unresolved. In Arabidopsis, moderate perturbations in photosynthetic activity, administered by short-term low light exposure or unexpected darkness, lead to increased lateral root (LR) initiation. Consistent with expression of low-energy markers, these treatments alter energy homeostasis and reduce sugar availability in roots. Here, we demonstrate that the LR response requires the metabolic stress sensor kinase Snf1-RELATED-KINASE1 (SnRK1), which phosphorylates the transcription factor BASIC LEUCINE ZIPPER63 (bZIP63) that directly binds and activates the promoter of AUXIN RESPONSE FACTOR19 (ARF19), a key regulator of LR initiation. Consistently, starvation-induced ARF19 transcription is impaired in bzip63 mutants. This study highlights a positive developmental function of SnRK1. During energy limitation, LRs are initiated and primed for outgrowth upon recovery. Hence, this study provides mechanistic insights into how energy shapes the agronomically important root system.
  •  
29.
  • Myalski, S., et al. (författare)
  • Isomeric Ratio for the I=8+ Yrast State in 96Pd Produced in the Relativistic Fragmentation of 107Ag
  • 2007
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1277-1282
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the preliminary results from a study of the decay of the I-pi = 8(+) T-1/2 = 2 mu s isomer in Pd-96 performed as part of the Stopped-Beam RISING campaign within the Rare Isotope Investigation at GSI (RISING). The Pd-96 ions were produced following the projectile fragmentation of a 750 MeV per nucleon Ag-107 primary beam. The reaction products were separated and identified by the in-flight method using the GSI Fragment Separator. The residues of interest were stopped in a perspex stopper surrounded by an array of 15, seven-element germanium Cluster detectors. One of the goals of the current work is to investigate the population of high-spin states produced projectile fragmentation reactions using isomeric ratio measurements to infer information on the angular momentum population distribution. In this short contribution the method and results of determining the isomeric ratio for the I-pi = 8(+) microsecond isomer in Pd-96 nucleus are presented.
  •  
30.
  • Myalski, S., et al. (författare)
  • Isomeric Ratios For Nuclei With Z=62-67 And A=142-152 Produced In The Relativistic Fragmentation Of Pb-208
  • 2009
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 40:3, s. 879-883
  • Tidskriftsartikel (refereegranskat)abstract
    • Isomeric states in nuclei with Z = 62-67 and A = 142-152 produced in the fragmentation of the relativistic (1 GeV/nucleon) Pb-208 beam were investigated. Isomeric ratios were determined for 10 isomeric states. Significant differences between theoretical and experimental values were observed.
  •  
31.
  • Myalski, S., et al. (författare)
  • Study of Isomer Production Rates for A=142-152 and Z=62-67 in Fragmentation of a Relativistic 208Pb Beam
  • 2012
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 43:2, s. 253-259
  • Tidskriftsartikel (refereegranskat)abstract
    • We have investigated nuclear fragmentation reactions of a relativistic Pb-208 beam. Ten isomeric states for nuclei with A = 142-152 and Z = 62-67 were observed. Measured isomeric ratios were compared, together with values from other experiments, with prediction of theoretical models. The discrepancies between the experimental and theoretical values were discussed in terms of transitions by-passing the isomer that are not included in the models.
  •  
32.
  • Neyens, G., et al. (författare)
  • g-Factor Measurements on Relativistic Isomeric Beams Produced by Fragmentation and U-fission: The g-RISING Project at GSI
  • 2007
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1237-1247
  • Tidskriftsartikel (refereegranskat)abstract
    • Within the RISING (Rare ISotope INvestigations @ GSI) Collaboration at GSI, g factor measurements have been performed on isomeric states in neutron-rich isotopes approaching Sn-132 and in the neutron deficient Pb-region (the g-RISING campaign). We present the experimental technique and some typical aspects related to such studies on relativistic beams selected with the FRS fragment separator. First results are presented for the (19/2(+)) 4.5 mu s isomeric state in Sn-127, which has been produced by means of fission of a relativistic U-238 beam on the one hand, and by the fragmentation of a relativistic Xe-136 beam on the other hand. Spin-alignment has been observed in both reactions. It was the first time that spin-alignment has been established in a relativistic fission reaction.
  •  
33.
  • Pietri, S., et al. (författare)
  • Experimental Details of the Stopped Beam RISING Campaign
  • 2007
  • Ingår i: The European Physical Journal. Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 150, s. 319-320
  • Tidskriftsartikel (refereegranskat)abstract
    • The RISING (Rare ISotope INvestigations at GSI) project constitutes a major pan-european initiative to study nuclear structure in exotic nuclei. A brief outline of the technical details specific to studies of isomeric decays following relativistic projectile fragmentation reactions is presented.
  •  
34.
  • Pietri, S., et al. (författare)
  • First Results from the Stopped Beam Isomer RISING Campaign at GSI
  • 2007
  • Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1255-1264
  • Tidskriftsartikel (refereegranskat)abstract
    • The first results from a series of experiments focused on the study of the internal structure of nuclei at the extremes of N:Z ratio using isomer spectroscopy are reported. These experiments represent the first of the Stopped Beam section of the Rare Isotopes Investigations at GSI (RISING) project. Exotic nuclei were synthesized using relativistic projectile fragmentation of similar to 500 -> 1000 MeV/u beams of Ag-107, Pb-208, Xe-136 and Ni-58, or fission of 750 MeV/u U-238 provided by the SIS synchrotron at GSI. A detailed description of the RISING stopped beam set up is given, together with a report of the performance of the associated gamma-ray spectrometer array. Selected results of the first experimental campaign are presented together with a discussion on the use of isomeric spectroscopy to study GeV range nuclear fragmentation. Details on future research plans of this collaboration are also outlined.
  •  
35.
  • Podolyak, Z, et al. (författare)
  • High Angular Momentum States Populated in Fragmentation Reactions
  • 2006
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 632:2-3, s. 203-206
  • Tidskriftsartikel (refereegranskat)abstract
    • The population of metastable states produced in relativistic-energy fragmentation of a U-238 beam has been measured. For states with angular momentum greater than or similar to 20h, a much higher population than expected has been observed. By introducing a collective component to the generation of angular momentum the experimental data can be understood. This is the first time that a collective degree of freedom has be shown to play a major role in such high-energy collisions. (c) 2005 Elsevier B.V. All rights reserved.
  •  
36.
  • Podolyak, Zs., et al. (författare)
  • Isomeric Decay Studies Around 204Pt and 148Tb
  • 2007
  • Ingår i: The European Physical Journal. Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 150, s. 165-168
  • Tidskriftsartikel (refereegranskat)abstract
    • Relativistic energy projectile fragmentation of Pb-208 has been used to produce a range of exotic nuclei. The nuclei of interest were studied by detecting delayed gamma rays following the decay of isomeric states. Experimental information on the excited states of the neutron-rich N = 126 nucleus, Pt-204, following internal decay of two isomeric states, was obtained for the first time. In addition, decays from the previously reported isomeric I=27h and I=(49/2)h states in Tb-148 and Gd-147, respectively, have been observed. These isomeric decays represent the highest spin discrete states observed to date following a projectile fragmentation reaction, and opens further the possibility of doing 'high-spin physics' using this technique.
  •  
37.
  • Podolyak, Zs., et al. (författare)
  • Structure of Neutron-rich Nuclei Around the N=126 Closed Shell; the Yrast Structure of 205Au up to Spin-parity I = (19/2+)
  • 2009
  • Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 42:3, s. 489-493
  • Konferensbidrag (refereegranskat)abstract
    • Heavy neutron-rich nuclei have been populated through the relativistic fragmentation of a Pb-208(82) beam at E/A = 1 GeV on a 2.5 g/cm(2) thick Be target. The synthesised nuclei were selected and identified in-flight using the fragment separator at GSI. Approximately 300 ns after production, the selected nuclei were implanted in an similar to 8 mm thick perspex stopper, positioned at the centre of the RISING gamma-ray detector spectrometer array. A previously unreported isomer with a half-life T-1/2 = 163(5) ns has been observed in the N = 126 closed-shell nucleus Au-205(79). Through gamma-ray singles and gamma-gamma coincidence analysis a level scheme was established. The comparison with a shell model calculation tentatively identifies the spin-parity of the excited states, including the isomer itself, which is found to be I-pi = (19/2(+)).
  •  
38.
  • Podolyak, Zs., et al. (författare)
  • Weakly Deformed Oblate Structures in 198Os
  • 2009
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 79:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Gamma rays de-exciting isomeric states in the neutron-rich nucleus Os-198(76)122 have been observed following relativistic projectile fragmentation of a 1 GeV per nucleon Pb-208 beam. The ground-state band has properties compatible with oblate deformation. The evolution of the structure of Os isotopes characterized by sudden prolate-oblate shape change is discussed and contrasted with the smooth change known in the Pt chain.
  •  
39.
  • Regan, P. H., et al. (författare)
  • First Results from the Stopped RISING Campaign at GSI: The Mapping of Isomeric Decays in Highly Exotic Nuclei
  • 2007
  • Ingår i: AIP Conference Proceedings. - : AIP. - 0094-243X. - 9780735413283 ; 899, s. 19-22
  • Konferensbidrag (refereegranskat)abstract
    • The first results from the Stopped Beam RISING experimental campaign performed at the GSI laboratory in Darmstadt, Germany, are presented. RISING (Rare ISotope INvestigations at GSI) constitutes a major new experimental program in European nuclear structure physics research aimed at using relativistic‐energy, projectile‐fragmentation reactions to study nuclei with exotic proton‐to‐neutron ratios. This paper introduces the physics aims of the Stopped RISING collaboration and presents some technical details and initial results from experiments using the RISING array to study decays from metastable nuclear states in both proton and neutron‐rich nuclei.
  •  
40.
  • Regan, P. H., et al. (författare)
  • Isomer Spectroscopy Using Relativistic Projectile Fragmentation at the N=Z Line for A~80-90
  • 2007
  • Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 787:1-4, s. 491-498
  • Tidskriftsartikel (refereegranskat)abstract
    • The preliminary results from the RISING Stopped Beam Isomer Campaign are presented, with specific focus on results of the initial experiment to investigate isomeric decays along the N=Z line around A similar to 80-90 following the projectile fragmentation of a Ag-107 primary beam at an energy of 750 MeV per nucleon. A description of the technical aspects behind the design of the RISING array is presented, together with evidence for previously unreported isomeric decays in Tc-87,Tc-88 and the N=Z nuclei Nb-82(41) and Tc-86(43).
  •  
41.
  • Rudolph, Dirk, et al. (författare)
  • Evidence for an Isomeric 3/2- State in 53Co
  • 2008
  • Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 36:2, s. 131-138
  • Tidskriftsartikel (refereegranskat)abstract
    • The fragmentation of a 550MeV/u primary beam of Ni-58 on a Be-9 target has been used to measure time-and energy-correlated gamma decays following the implantation of event-by-event discriminated secondary fragments into a Be-9 stopper plate. A new isomeric gamma decay with T-1/2 = 14(6 4) ns and E-gamma = 646.2(2) keV is observed and attributed to the decay of the yrast 3/2-state in Co-53(27)26. This short-lived isomeric state has been populated by means of nuclear reactions during the stopping process of the secondary fragments. The experimental findings are discussed in the framework of large-scale spherical shell model calculations in conjunction with isospin symmetry-breaking residual interactions for the A = 53, Tz = +/- 1/2 mirror nuclei Co-53 and Fe-53.
  •  
42.
  • Rudolph, Dirk, et al. (författare)
  • Exciting Isomers from the First Stopped-beam RISING Campaign
  • 2007
  • Ingår i: The European Physical Journal. Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 150, s. 173-176
  • Tidskriftsartikel (refereegranskat)abstract
    • First results are reported from a major new initiative of experiments, which focus on nuclear structure studies at extreme isospin values by means of isomer spectroscopy. The experiments represent the first part of the so-called stopped-beam campaign within the Rare ISotope INvestigations at GSI (RISING) project. Time-correlated gamma decays from individually identified nuclear species have been measured, allowing the clean identification of isomeric decays in a wide range of exotic nuclei both at the proton drip-line and in heavy, neutron-rich systems. An overview of the experimental technique will be given, together with the performance of the new germanium detector array and future research plans for the collaboration.
  •  
43.
  • Rudolph, Dirk, et al. (författare)
  • Isospin Symmetry and Proton Decay: Identification of the 10+ Isomer in 54Ni
  • 2008
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 78:2
  • Tidskriftsartikel (refereegranskat)abstract
    • The gamma decays from an isomeric 10+ state at 6457 keV in the nucleus 54Ni have been identified using the GSI fragment separator in conjunction with the RISING Ge-detector array. The state is interpreted as the isobaric analog of the 6527-keV 10+ isomer in 54Fe. The results are discussed in terms of isospin-dependent shell-model calculations. Clear evidence is presented for a discrete l = 5 proton decay branch into the first excited 9/2- state of the daughter 53Co. This decay is the first of its kind observed following projectile fragmentation reactions.
  •  
44.
  • Soudris, Dimitrios, et al. (författare)
  • EXA2PRO programming environment: Architecture and Applications
  • 2018
  • Ingår i: 2018 INTERNATIONAL CONFERENCE ON EMBEDDED COMPUTER SYSTEMS: ARCHITECTURES, MODELING, AND SIMULATION (SAMOS XVIII). - New York, NY, USA : ASSOC COMPUTING MACHINERY. - 9781450364942 ; , s. 202-209
  • Konferensbidrag (refereegranskat)abstract
    • The EXA2PRO programming environment will integrate a set of tools and methodologies that will allow to systematically address many exascale computing challenges, including performance, performance portability, programmability, abstraction and reusability, fault tolerance and technical debt. The EXA2PRO tool-chain will enable the efficient deployment of applications in exascale computing systems, by integrating high-level software abstractions that offer performance portability and efficient exploitation of exascale systems heterogeneity, tools for efficient memory management, optimizations based on trade-offs between various metrics and fault-tolerance support. Hence, by addressing various aspects of productivity challenges, EXA2PRO is expected to have significant impact in the transition to exascale computing, as well as impact from the perspective of applications. The evaluation will be based on 4 applications from 4 different domains that will be deployed in JUELICH supercomputing center. The EXA2PRO will generate exploitable results in the form of a tool-chain that support diverse exascale heterogeneous supercomputing centers and concrete improvements in various exascale computing challenges.
  •  
45.
  • Steer, S. J., et al. (författare)
  • Isomeric Decay Studies In Neutron-Rich N Approximate To 126 Nuclei
  • 2009
  • Ingår i: International Journal Of Modern Physics E-Nuclear Physics. - 0218-3013. ; 18:4, s. 1002-1007
  • Konferensbidrag (refereegranskat)abstract
    • Heavy neutron-rich nuclei were populated via relativistic energy fragmentation of a E/A= 1 GeV Pb-208 beam. The nuclei of interest were selected and identified by a fragment separator and then implanted in a passive plastic stopper. Delayed. rays following internal isomeric decays were detected by the RISING array. Experimental information was obtained on a number of nuclei with Z=73-80 (Ta-Hg), providing new information both on the prolate-oblate transitional region as well as on the N=126 closed shell nuclei.
  •  
46.
  • Steer, S. J., et al. (författare)
  • Isomeric States Observed in Heavy Neutron-rich Nuclei Populated in the Fragmentation of a 208Pb Beam
  • 2011
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 84:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Heavy neutron-rich nuclei were populated via the fragmentation of a E/A = 1 GeV Pb-208(82) beam. Secondary fragments were separated and identified and subsequently implanted in a passive stopper. By the detection of delayed gamma rays, isomeric decays associated with these nuclei have been identified. A total of 49 isomers were detected, with the majority of them observed for the first time. The newly discovered isomers are in Hg-204,205(80), Au-201,202,204,205(79), Pt-197,203,204(78), Ir-195,199-203(77), Os-193,197-199(76), Re-196(75), W-190,191(74), and Ta-189(73). Possible level schemes are constructed and the structure of the nuclei discussed. To aid the interpretation, shell-model as well as BCS calculations were performed.
  •  
47.
  • Steer, S. J., et al. (författare)
  • Single-particle Behavior at N=126: Isomeric Decays in Neutron-rich 204Pt
  • 2008
  • Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 78:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The four proton-hole nucleus Pt-204 was populated in the fragmentation of an E/A = 1 GeV Pb-208 beam. The yrast structure of Pt-204 has been observed up to angular momentum I = 10h by detecting delayed gamma-ray transitions originating from metastable states. These long-lived excited states have been identified to have spin-parities of I-pi = (10(+)), (7(-)), and (5(-)) and half-lives of T-1/2 = 146(14) ns, 55(3) mu s, and 5.5(7) mu s, respectively. The structure of the magic N = 126 Pt-204 nucleus is discussed and understood in terms of the spherical shell model. The data suggest a revision of the two-body interaction for N = 126, Z < 82, which determines the evolution of nuclear structure toward the r-process waiting point nuclei.
  •  
48.
  • Taylor, MJ, et al. (författare)
  • Spectroscopy of Nuclei Approaching the Proton Drip-line Using a Secondary-fragmentation Technique with the RISING Detector Array
  • 2005
  • Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. 1527-1530
  • Tidskriftsartikel (refereegranskat)abstract
    • An experiment utilizing a double fragmentation reaction was performed to study isobaric analogue states in A similar to 50 nuclei approaching the proton drip-line. gamma-ray spectroscopy will be used to identify excited states in the neutron-deficient nuclei produced in the second fragmentation reaction. Excited state level schemes will be obtained, through comparison with states in their well-known mirror partners, along with information on Coulomb effects through measurements of the Coulomb energy differences between isobaric analogue excited states. The validity of isospin symmetry for nuclei approaching the proton drip-line can also be investigated and the information gained will aid in testing and improving fp shell model calculations. The analysis of the collected data is at a preliminary stage and current status of this work is reported.
  •  
49.
  • Waldkirch, Eginhard, et al. (författare)
  • Non-genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue
  • 2008
  • Ingår i: BJU International. - : Blackwell Publishing Ltd. - 1464-4096 .- 1464-410X. ; 101:1, s. 71-74
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES To evaluate non-genomic effects of testosterone and dihydrotestosterone (DHT) on isolated human cavernosal arteries (HCA) and corpus cavernosum (HCC) using organ-bath studies and radio-immunoassays (RIA), as non-genomic effects of androgens are reported for vascular smooth musculature and there is evidence that the relaxant response involves a modulation of cyclic nucleotide tissue levels. MATERIALS AND METHODS The relaxation induced by the cumulative addition of testosterone and DHT (0.01-10 mu M) was studied using circular segments of HCA and strip preparations of HCC. To evaluate the effects of testosterone and DHT on tissue levels of cAMP and cGMP, specimens were exposed to increasing concentrations of the hormones. Forskolin and sodium nitroprusside (SNP) served as reference compounds. RESULTS Testosterone and DHT dose-dependently reversed the noradrenaline-induced tension of vascular segments and HCC strips. At the maximum concentration, testosterone and DHT reduced the mean (SD) tension to 79.8 (4.43)% and 83.9 (10.94)%, respectively. SNP and forskolin significantly stimulated the production of cGMP and cAMP. No effects of testosterone and DHT on cGMP and cAMP levels were detected. CONCLUSION Rapid androgen-induced relaxation of HCA and HCC occurs via non-genomic mechanisms. In penile erectile tissue, non-genomic relaxant effects of testosterone and DHT are not mediated via modulation of cyclic nucleotide tissue levels. Additional studies are required to establish if non-genomic relaxant effects are important in ensuring a basal level of perfusion to maintain overall penile function.
  •  
50.
  • Weiszflog, M., et al. (författare)
  • High-spin Spectroscopy of 63Ga and 65Ga
  • 2001
  • Ingår i: European Physical Journal A. Hadrons and Nuclei. - 1434-6001. ; 11, s. 25-38
  • Tidskriftsartikel (refereegranskat)abstract
    • High-spin states in the nuclei Ga-63 and Ga-65 were studied following the reaction S-32 + Ca-40 at a reaction energy of 125 MeV and using the GASP gamma -ray spectrometer in combination with the ISIS charged-particle detector system. In addition to low-lying negative-parity states with single-particle character, rotational-like cascades built on the 9/2(+) and 19/2(-) states have been observed in both nuclei. Sidebands with negative parity in Ga-63 and positive parity in Ga-65 could be established. The experimental results are compared with Total Routhian Surface calculations which describe the nuclei as moderately deformed (beta (2) approximate to 0.25) and gamma soft at low rotational frequencies. The highest experimentally observed positive-parity state in Ga-65 (41/2(+)) is in good agreement with the calculated crossing of the collective band with a non-collective one terminating at this spin.
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