| 1. |
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| 2. |
- Jackowski, Christian, 1975-, et al.
(författare)
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Quantitative MRI in Isotropic Spatial Resolution for Forensic Soft Tissue Documentation. Why and How?
- 2011
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Ingår i: Journal of Forensic Sciences. - : Blackwell. - 0022-1198 .- 1556-4029. ; 56:1, s. 208-215
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Tidskriftsartikel (refereegranskat)abstract
- A quantification of T1, T2, and PD in high isotropic resolution was performed on corpses. Isotropic and quantified postmortem magnetic resonance (IQpmMR) enables sophisticated 3D postprocessing, such as reformatting and volume rendering. The body tissues can be characterized by the combination of these three values. The values of T1, T2, and PD were given as coordinates in a T1-T2-PD space where similar tissue voxels formed clusters. Implementing in a volume rendering software enabled color encoding of specific tissues and pathologies in 3D models of the corpse similar to computed tomography, but with distinctively more powerful soft tissue discrimination. From IQpmMR data, any image plane at any contrast weighting may be calculated or 3D color-encoded volume rendering may be carried out. The introduced approach will enable future computer-aided diagnosis that, e.g., checks corpses for a hemorrhage distribution based on the knowledge of its T1-T2-PD vector behavior in a high spatial resolution.
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| 3. |
- Aad, G., et al.
(författare)
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Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 875-916
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS detector at the Large Hadron Collider has collected several hundred million cosmic ray events during 2008 and 2009. These data were used to commission the Muon Spectrometer and to study the performance of the trigger and tracking chambers, their alignment, the detector control system, the data acquisition and the analysis programs. We present the performance in the relevant parameters that determine the quality of the muon measurement. We discuss the single element efficiency, resolution and noise rates, the calibration method of the detector response and of the alignment system, the track reconstruction efficiency and the momentum measurement. The results show that the detector is close to the design performance and that the Muon Spectrometer is ready to detect muons produced in high energy proton-proton collisions.
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| 4. |
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| 5. |
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| 6. |
- Aad, G., et al.
(författare)
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Readiness of the ATLAS Tile Calorimeter for LHC collisions
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:4, s. 1193-1236
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Tidskriftsartikel (refereegranskat)abstract
- The Tile hadronic calorimeter of the ATLAS detector has undergone extensive testing in the experimental hall since its installation in late 2005. The readout, control and calibration systems have been fully operational since 2007 and the detector has successfully collected data from the LHC single beams in 2008 and first collisions in 2009. This paper gives an overview of the Tile Calorimeter performance as measured using random triggers, calibration data, data from cosmic ray muons and single beam data. The detector operation status, noise characteristics and performance of the calibration systems are presented, as well as the validation of the timing and energy calibration carried out with minimum ionising cosmic ray muons data. The calibration systems' precision is well below the design value of 1%. The determination of the global energy scale was performed with an uncertainty of 4%.
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| 7. |
- Aad, G., et al.
(författare)
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Studies of the performance of the ATLAS detector using cosmic-ray muons
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:3
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Tidskriftsartikel (refereegranskat)abstract
- Muons from cosmic-ray interactions in the atmosphere provide a high-statistics source of particles that can be used to study the performance and calibration of the ATLAS detector. Cosmic-ray muons can penetrate to the cavern and deposit energy in all detector subsystems. Such events have played an important role in the commissioning of the detector since the start of the installation phase in 2005 and were particularly important for understanding the detector performance in the time prior to the arrival of the first LHC beams. Global cosmic-ray runs were undertaken in both 2008 and 2009 and these data have been used through to the early phases of collision data-taking as a tool for calibration, alignment and detector monitoring. These large datasets have also been used for detector performance studies, including investigations that rely on the combined performance of different subsystems. This paper presents the results of performance studies related to combined tracking, lepton identification and the reconstruction of jets and missing transverse energy. Results are compared to expectations based on a cosmic-ray event generator and a full simulation of the detector response.
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| 8. |
- Aad, G., et al.
(författare)
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The ATLAS Inner Detector commissioning and calibration
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 787-821
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 mu m and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks.
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| 9. |
- Aad, G., et al.
(författare)
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The ATLAS Simulation Infrastructure
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 823-874
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Tidskriftsartikel (refereegranskat)abstract
- The simulation software for the ATLAS Experiment at the Large Hadron Collider is being used for large-scale production of events on the LHC Computing Grid. This simulation requires many components, from the generators that simulate particle collisions, through packages simulating the response of the various detectors and triggers. All of these components come together under the ATLAS simulation infrastructure. In this paper, that infrastructure is discussed, including that supporting the detector description, interfacing the event generation, and combining the GEANT4 simulation of the response of the individual detectors. Also described are the tools allowing the software validation, performance testing, and the validation of the simulated output against known physics processes.
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| 10. |
- Abolins, M., et al.
(författare)
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The ATLAS Data Acquisition and High Level Trigger system
- 2016
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the data acquisition and high level trigger system of the ATLAS experiment at the Large Hadron Collider at CERN, as deployed during Run 1. Data flow as well as control, configuration and monitoring aspects are addressed. An overview of the functionality of the system and of its performance is presented and design choices are discussed.
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| 11. |
- Antonsson, Ann-Beth, 1956-, et al.
(författare)
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Fatal Carbon Monoxide Intoxication After AcetyleneGas Welding of Pipes
- 2013
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press. - 0003-4878 .- 1475-3162. ; 57:5, s. 662-666
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Tidskriftsartikel (refereegranskat)abstract
- Acetylene gas welding of district heating pipes can result in exposure to high concentrations of carbon monoxide. A fatal case due to intoxication is described. Measurements of carbon monoxide revealed high levels when gas welding a pipe with closed ends. This fatality and these measurements highlight a new hazard, which must be promptly prevented.
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| 12. |
- Berge, Kjell Lars, et al.
(författare)
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Vage kunnskapsløfter
- 2008
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Ingår i: Aftenposten (morgenutg. : trykt utg.). ; 17 mar
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 13. |
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| 14. |
- Betancourt, Lazaro Hiram, et al.
(författare)
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The human melanoma proteome atlas-Defining the molecular pathology
- 2021
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Ingår i: Clinical and Translational Medicine. - : Wiley. - 2001-1326. ; 11:7, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.
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| 15. |
- Birkeland, Einar, et al.
(författare)
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Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma
- 2013
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Ingår i: Clinical and Experimental Metastasis. - : Springer Science and Business Media LLC. - 1573-7276 .- 0262-0898. ; 30:7, s. 867-876
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Tidskriftsartikel (refereegranskat)abstract
- Metastatic melanoma is characterized by a poor response to chemotherapy. Furthermore, there is a lack of established predictive and prognostic markers. In this single institution study, we correlated mutation status and expression levels of BRAF and NRAS to dacarbazine (DTIC) treatment response as well as progression-free and overall survival in a cohort of 85 patients diagnosed with advanced melanoma. Neither BRAF nor NRAS mutation status correlated to treatment response. However, patients with tumors harboring NRAS mutations had a shorter overall survival (p < 0.001) compared to patients with tumors wild-type for NRAS. Patients having a clinical benefit (objective response or stable disease at 3 months) on DTIC therapy had lower BRAF and NRAS expression levels compared to patients progressing on therapy (p = 0.037 and 0.003, respectively). For BRAF expression, this association was stronger among patients with tumors wild-type for BRAF (p = 0.005). Further, low BRAF as well as NRAS expression levels were associated with a longer progression-free survival in the total population (p = 0.004 and < 0.001, respectively). Contrasting low NRAS expression levels, which were associated with improved overall survival in the total population (p = 0.01), low BRAF levels were associated with improved overall survival only among patients with tumors wild-type for BRAF (p = 0.013). These findings indicate that BRAF and NRAS expression levels may influence responses to DTIC as well as prognosis in patients with advanced melanoma.
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| 16. |
- Brandsma, Corry Anke, et al.
(författare)
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Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1
- 2020
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Ingår i: Thorax. - : BMJ. - 0040-6376 .- 1468-3296. ; 75:2, s. 180-183
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Tidskriftsartikel (refereegranskat)abstract
- Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.
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| 17. |
- Fernández-Fernández, P., et al.
(författare)
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Different effects of warming treatments in forests versus hedgerows on the understorey plant Geum urbanum
- 2022
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Ingår i: Plant Biology. - : Wiley. - 1435-8603 .- 1438-8677. ; 24:5, s. 734-744
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Tidskriftsartikel (refereegranskat)abstract
- The effectiveness of hedgerows as functional corridors in the face of climate warming has been little researched. Here we investigated the effects of warming temperatures on plant performance and population growth of Geum urbanum in forests versus hedgerows in two European temperate regions.Adult individuals were transplanted in three forest–hedgerow pairs in each of two different latitudes, and an experimental warming treatment using open-top chambers was used in a full factorial design. Plant performance was analysed using mixed models and population performance was analysed using Integral Projection Models and elasticity analyses.Temperature increases due to open-top chamber installation were higher in forests than in hedgerows. In forests, the warming treatment had a significant negative effect on the population growth rate of G. urbanum. In contrast, no significant effect of the warming treatment on population dynamics was detected in hedgerows. Overall, the highest population growth rates were found in the forest control sites, which was driven by a higher fecundity rather than a higher survival probability.Effects of warming treatments on G. urbanum population growth rates differed between forests and hedgerows. In forests, warming treatments negatively affected population growth, but not in hedgerows. This could be a consequence of the overall lower warming achieved in hedgerows. We conclude that maintenance of cooler forest microclimates coul, at least temporarily, moderate the species response to climate warming.
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| 18. |
- Gil, Jeovanis, et al.
(författare)
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Clinical protein science in translational medicine targeting malignant melanoma
- 2019
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Ingår i: Cell Biology and Toxicology. - : Springer Science and Business Media LLC. - 0742-2091 .- 1573-6822. ; 35:4, s. 293-332
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Tidskriftsartikel (refereegranskat)abstract
- Melanoma of the skin is the sixth most common type of cancer in Europe and accounts for 3.4% of all diagnosed cancers. More alarming is the degree of recurrence that occurs with approximately 20% of patients lethally relapsing following treatment. Malignant melanoma is a highly aggressive skin cancer and metastases rapidly extend to the regional lymph nodes (stage 3) and to distal organs (stage 4). Targeted oncotherapy is one of the standard treatment for progressive stage 4 melanoma, and BRAF inhibitors (e.g. vemurafenib, dabrafenib) combined with MEK inhibitor (e.g. trametinib) can effectively counter BRAFV600E-mutated melanomas. Compared to conventional chemotherapy, targeted BRAFV600E inhibition achieves a significantly higher response rate. After a period of cancer control, however, most responsive patients develop resistance to the therapy and lethal progression. The many underlying factors potentially causing resistance to BRAF inhibitors have been extensively studied. Nevertheless, the remaining unsolved clinical questions necessitate alternative research approaches to address the molecular mechanisms underlying metastatic and treatment-resistant melanoma. In broader terms, proteomics can address clinical questions far beyond the reach of genomics, by measuring, i.e. the relative abundance of protein products, post-translational modifications (PTMs), protein localisation, turnover, protein interactions and protein function. More specifically, proteomic analysis of body fluids and tissues in a given medical and clinical setting can aid in the identification of cancer biomarkers and novel therapeutic targets. Achieving this goal requires the development of a robust and reproducible clinical proteomic platform that encompasses automated biobanking of patient samples, tissue sectioning and histological examination, efficient protein extraction, enzymatic digestion, mass spectrometry–based quantitative protein analysis by label-free or labelling technologies and/or enrichment of peptides with specific PTMs. By combining data from, e.g. phosphoproteomics and acetylomics, the protein expression profiles of different melanoma stages can provide a solid framework for understanding the biology and progression of the disease. When complemented by proteogenomics, customised protein sequence databases generated from patient-specific genomic and transcriptomic data aid in interpreting clinical proteomic biomarker data to provide a deeper and more comprehensive molecular characterisation of cellular functions underlying disease progression. In parallel to a streamlined, patient-centric, clinical proteomic pipeline, mass spectrometry–based imaging can aid in interrogating the spatial distribution of drugs and drug metabolites within tissues at single-cell resolution. These developments are an important advancement in studying drug action and efficacy in vivo and will aid in the development of more effective and safer strategies for the treatment of melanoma. A collaborative effort of gargantuan proportions between academia and healthcare professionals has led to the initiation, establishment and development of a cutting-edge cancer research centre with a specialisation in melanoma and lung cancer. The primary research focus of the European Cancer Moonshot Lund Center is to understand the impact that drugs have on cancer at an individualised and personalised level. Simultaneously, the centre increases awareness of the relentless battle against cancer and attracts global interest in the exceptional research performed at the centre.
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| 19. |
- Gudmannsson, Petur, et al.
(författare)
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A Unique Fatal Moose Attack Mimicking Homicide
- 2018
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Ingår i: Journal of Forensic Sciences. - : John Wiley & Sons. - 0022-1198 .- 1556-4029. ; 63:2, s. 622-625
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Tidskriftsartikel (refereegranskat)abstract
- Fatalities caused by animal attacks are rare, but have the potential to mimic homicide. We present a case in which a moose attacked and killed a woman who was walking her dog in a forest. Autopsy showed widespread blunt trauma with a large laceration on one leg in which blades of grass were embedded. Flail chest was the cause of death. The case was initially conceived as homicide by means of a riding lawn mower. A review of the case by moose experts and analyses of biological trace material that proved to originate from moose, established the true source of injury. The dog probably provoked a moose, which, in response, stomped and gored the victim to death. The injuries resembled those previously reported from attacks by cattle and water buffalo. Fatal moose attacks constitute an extremely rare threat in boreal areas, but can be considered in traumatic deaths of unknown cause.
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| 20. |
- Jackowski, Christian, 1975-, et al.
(författare)
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Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI
- 2011
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; Jan;21:1, s. 70-78
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate the performance of postmortem magnetic resonance imaging (pmMRI) in identification and characterization of lethal myocardial infarction in a non-invasive manner on human corpses.MATERIALS AND METHODS: Before forensic autopsy, 20 human forensic corpses were examined on a 1.5-T system for the presence of myocardial infarction. Short axis, transversal and longitudinal long axis images (T1-weighted; T2-weighted; PD-weighted) were acquired in situ. In subsequent autopsy, the section technique was adapted to short axis images. Histological investigations were conducted to confirm autopsy and/or radiological diagnoses.RESULTS: Nineteen myocardial lesions were detected and age staged with pmMRI, of which 13 were histologically confirmed (chronic, subacute and acute). Six lesions interpreted as peracute by pmMRI showed no macroscopic or histological finding. Five of the six peracute lesions correlated well to coronary pathology, and one case displayed a severe hypertrophic alteration.CONCLUSION: pmMRI reliably demonstrates chronic, subacute and acute myocardial infarction in situ. In peracute cases pmMRI may display ischemic lesions undetectable at autopsy and routine histology. pmMRI has the potential to substantiate autopsy and to counteract the loss of reliable information on causes of death due to the recent disappearance of the clinical autopsy.
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| 21. |
- Karmali, Kunal N., et al.
(författare)
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Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure : A meta-analysis of individual participant data
- 2018
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Ingår i: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 15:3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Clinical practice guidelines have traditionally recommended blood pressure treatment based primarily on blood pressure thresholds. In contrast, using predicted cardiovascular risk has been advocated as a more effective strategy to guide treatment decisions for cardiovascular disease (CVD) prevention. We aimed to compare outcomes from a blood pressure-lowering treatment strategy based on predicted cardiovascular risk with one based on systolic blood pressure (SBP) level.Methods and findings: We used individual participant data from the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC) from 1995 to 2013. Trials randomly assigned participants to either blood pressure-lowering drugs versus placebo or more intensive versus less intensive blood pressure-lowering regimens. We estimated 5-y risk of CVD events using a multivariable Weibull model previously developed in this dataset. We compared the two strategies at specific SBP thresholds and across the spectrum of risk and blood pressure levels studied in BPLTTC trials. The primary outcome was number of CVD events avoided per persons treated. We included data from 11 trials (47,872 participants). During a median of 4.0 y of follow-up, 3,566 participants (7.5%) experienced a major cardiovascular event. Areas under the curve comparing the two treatment strategies throughout the range of possible thresholds for CVD risk and SBP demonstrated that, on average, a greater number of CVD events would be avoided for a given number of persons treated with the CVD risk strategy compared with the SBP strategy (area under the curve 0.71 [95% confidence interval (CI) 0.70-0.72] for the CVD risk strategy versus 0.54 [95% CI 0.53-0.55] for the SBP strategy). Compared with treating everyone with SBP >= 150 mmHg, a CVD risk strategy would require treatment of 29% (95% CI 26%-31%) fewer persons to prevent the same number of events or would prevent 16% (95% CI 14%-18%) more events for the same number of persons treated. Compared with treating everyone with SBP >= 140 mmHg, a CVD risk strategy would require treatment of 3.8% (95% CI 12.5% fewer to 7.2% more) fewer persons to prevent the same number of events or would prevent 3.1% (95% CI 1.5%-5.0%) more events for the same number of persons treated, although the former estimate was not statistically significant. In subgroup analyses, the CVD risk strategy did not appear to be more beneficial than the SBP strategy in patients with diabetes mellitus or established CVD.Conclusions: A blood pressure-lowering treatment strategy based on predicted cardiovascular risk is more effective than one based on blood pressure levels alone across a range of thresholds. These results support using cardiovascular risk assessment to guide blood pressure treatment decision-making in moderate- to high-risk individuals, particularly for primary prevention.
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| 22. |
- Lönngren, Johanna, Docent, 1985-, et al.
(författare)
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Learning for an unknown future : emotional positioning in and for expansive learning
- 2023
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Konferensbidrag (refereegranskat)abstract
- STUDY OVERVIEW AND PURPOSE: We live in troubled times. Faced with increasingly serious and urgent, wicked sustainability challenges (Lönngren & van Poeck, 2021; United Nations, 2015), such as climate change, pandemics, and violent conflict , more and more people experience anxiety, hopelessness, and worries about the future (Barrineau et al., 2022; Ojala et al., 2021; Pihkala, 2020). The United Nations’ Agenda 2030 with its 17 Sustainable Development Goals (SDGs; United Nations, 2015) may offer a comforting illusion of a yellow brick road to a known and livable future. Yet, complex systems studies have shown that the future is not only unknown but ultimately unknowable (Dewulf & Biesbroek, 2018; Funtowicz & Ravetz, 1993). In light of such radical uncertainty, Barrineau et al. (2022) argued that environmental and sustainability education (ESE) is not only about “promoting [pre-defined] skills and competencies in sustainability education with which to equip students to tackle sustainability challenges” (p.3) since we do not know yet what competencies they will need. The only thing we know for certain is that future generations will need to develop knowledge, skills, and practices that are different from those we know today, that is, those that have given rise to our current predicaments. In other words, students need to “learn something that is not yet there” (Engeström & Sannino, 2010, p. 2).In recent years, a range of educational theories and concepts that touch upon this type of learning have increased in popularity. For example, Engeström et al. (Engeström et al., 2022; Engeström & Sannino, 2010) have drawn on cultural historical activity theory to examine expansive learningprocesses that allow learners to develop “expanded pattern[s] of activity, corresponding theoretical concept[s], and new types of agency” (Engeström & Sannino, 2010, p. 7). Similarly, Barrineau et al. (2022) have described emergentist education as a form of teaching and learning that engages with “the possibilities of the not-yet-imagined” (p.2). Others have described related theories, such as transformative and transgressive social learning as crucially important in ESE (Lotz-Sisitka et al., 2015).These and other traditions of transformative and expansive learning theories have in common that they attend to the role of social interaction for learning, stressing that learning always takes place in social contexts (Lenglet, 2022; Lotz-Sisitka et al., 2015; Van Poeck et al., 2020). Another common thread through many approaches is an attention to spirituality, affect, and/or emotions (Hoggan, 2016; Lenglet, 2022; Lotz-Sisitka et al., 2015). For example, Hoggan (2016) argued that learners must be “emotionally capable of change” (p. 61), pay attention to emotional experiences, and learn to utilize emotional ways of knowing. Similarly, Östman et al. (2019) have used pragmatist theories to argue that strong embodied experiences can trigger transformative learning. This intersection between expansive learning, social interaction, and emotions is the focus of our contribution.The aim of our study is to explore how expansive learning can manifest in and through emotional interaction when student groups engage with wicked sustainability challenges. To do so, we draw on positioning theory as a theoretical tool that allows us to study emotions as a form of social interaction (Harré & van Langenhove, 1999) rather than something individuals have and experience. More specifically, we explore processes of emotional positioning (Lönngren et al., 2021; Lönngren & Berge, forthcoming), analyzing how students use emotions discursively to position themselves – and each other – in relation to their (expansive) learning and (future) agency to work for sustainable and desired futures.METHODS: Emotions can be expressed through a wide range of modalities (e.g., speech, gestures, facial expressions, intonation, bodily positions). Therefore, multimodal approaches are particularly suitable for studying how emotions are expressed and used in social interaction (Goodwin et al., 2012; Hufnagel & Kelly, 2018; Lönngren & Berge, forthcoming). For this study, we video-recorded group work conducted by four groups of engineering students. The group work sessions took place during two sustainability courses for engineering students at two Swedish universities and they were part of the students’ regular course work. No researchers were present during the sessions, but teachers entered each room occasionally to check on the groups’ progress. In total, we recorded approximately 70 hours of video data. To analyze the data, we first watched all recordings (~70h) to familiarize ourselves with the data. Thereafter, we formulated sensitizing concepts (consensus/dissensus, convergence/divergence, comfort/vulnerability, intensity, and social positions) to narrow our focus on situations in which we could study emotional positioning and/or expansive learning processes. The sensitizing concepts allowed us to select a smaller number of excerpts for in-depth analysis. For each excerpt, we then developed narrative descriptions of any processes of expansivity and expansive learning we could observe. Finally, we applied the analytic tools of positioning theory to make sense of the ways in which students used emotions discursively while engaging (or not) in expansive learning.PRELIMINARY FINDINGS AND CONCLUSIONS: Our preliminary findings point to multiple ways in which emotional positioning could facilitate expansive learning during group engagement with wicked challenges. For example, when students suggested norm-breaking methods or solution approaches, other students could validate those ideas by listening attentively and expressing excitement. By validating unconventional ideas, the students also positioned themselves and each other as expansive learners with rights and duties to reach beyond known approaches and solutions. In other excerpts, we observed high levels of emotional congruence between the group members. When one student laughed, others would often join in. In other instances, students would fall silent simultaneously, much like a general pause in an orchestra concert. By enacting these and other forms of emotional congruence, the students could co-construct their group as a team – working together, building on each other’s ideas, and taking collective responsibility for any outcomes they produced. Thus, they also constructed a shared safety-net, reducing perceived risks associated with expansive learning: If the outcomes of their work had turned out to be flawed or ridiculed by others, they could have shared the burden of the perceived (!) failure and helped each other focus on the exceptional learning they had achieved. These findings demonstrate how students could use emotions discursively to position themselves and each other as (a) students who can and should engage in expansive learning, and (b) sustainability agents who can and should contribute to developing innovative solutions to wicked issues. The findings also show how emotions expressed in interaction can have profound impacts on learning, which further stresses the importance of more ESE research on emotions in and as social interaction. A better understanding of emotional interaction in ESE would also support educators in developing teaching and learning environments conducive to expansive learning.
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| 23. |
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| 24. |
- Lönngren, Johanna, 1985-, et al.
(författare)
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Taking emotions seriously in sustainability education : A theoretical exploration of “emotional scaffolding” and how it can be used in research and practice
- 2021
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Konferensbidrag (refereegranskat)abstract
- Background: Research has shown that emotions profoundly affect teaching and learning in all disciplines and at all levels of education. Emotions may be particularly important in environmental and sustainability education (ESE) due the seriousness and complexity of sustainability concerns and the presence of conflicting norms and values (Lönngren, Adawi, & Svanström, 2019; Ojala, 2015). For example, emotions may motivate students and teachers to engage in discussions about controversial topics (such as climate change) and guide judgment and decision-making in the face of uncertainty and ambiguity. However, they may also lead to denial of uncomfortable knowledge (Bossér & Lindahl, 2019; Ojala, 2013). Despite the importance of emotions in ESE, research on this topic is only emerging at this point. In addition, most of the existing research focuses on emotions as individual and private phenomena (Zembylas, 2007), such as hope or individual emotional regulation. However, research also suggests that expressing emotions in social contexts may play an important role in ESE. Emotions are closely related to personal values and explicating personal values is important in ESE (Ojala, 2013). An interesting theoretical concept for exploring emotions in ESE as social and relational phenomena is “emotional scaffolding” (also called affective scaffolding), which refers to pedagogical support teachers provide to influence students’ emotions in order to improve learning (Rosiek, 2003). While emotional scaffolding has been used previously (Park, 2016; van de Pol, Volman, & Beishuizen, 2010), we argue that it is conceptualized in a narrow way and remains under-theorized. Specifically, the current definition of emotional scaffolding seems to be based on a narrow empirical context or a narrow set of identified discursive practices, and it ignores recent theory and research on emotions in education. In this theoretical contribution, we draw on a nascent body of research on emotional scaffolding across various disciplines as well as a typology of academic emotions to (1) develop a broader and more theoretically informed definition of emotional scaffolding, (2) explore ways of researching emotional scaffolding, and (3) suggest ways of drawing out educational implications from research on emotional scaffolding. Method: To this end, we start from Rosiek’s widely cited definition of emotional scaffolding as “teachers’ pedagogical use of analogies, metaphors, and narratives to influence students’ emotional response to specific aspects of the subject matter in a way that promotes student learning” (Rosiek, 2003, p. 402). We broaden and unpack this definition in four important ways. First, to broaden it beyond the “use of analogies, metaphors, and narratives”, we identify additional tools and strategies teachers can use, such as acknowledging and validating expression of emotions (Ojala, 2013; Park, 2016), providing encouragement and reassurance (Lönngren et al., 2019; Meyer & Turner, 2007), adjusting subject content to students’ needs (Lönngren, 2017; McCaughtry, 2004), and building positive relationships in the classroom (Ojala, 2013; Park, 2016). Second, to unpack the definition of “emotional response”, we draw on research describing different types of emotional responses, such as emotional experiences (e.g. confidence rather than anxiety) or expressions (e.g. expressing trust or engagement) (Meyer & Turner, 2007; van de Pol et al., 2010). Third, to broaden the definition beyond students’ emotional response to “subject matter”, we use Pekrun and Linnenbrink-Garcia’s (2012) typology of academic emotions, according to which emotional responses to subject matter can be described as topic emotions. The typology contains three additional types of academic emotions that are relevant for emotional scaffolding: achievement emotions (i.e. emotions related to students’ perception of their academic performance, such as worry about not being able to provide a perfect solution to a sustainability problem), epistemic emotions (i.e. emotions related to the process of learning, such as grappling with uncertainty and ambiguity), and social emotions (i.e. emotions related to classroom interaction and social relationships). Finally, we adopt a critical lens to unpack the overall aim of emotional scaffolding — what it could mean that emotional scaffolding in ESE “promotes student learning”. Here, we ask questions such as “What types of learning?” and “Learning for whom?”. Based on our broadened definition of emotional scaffolding, we then explore ways of researching emotional scaffolding in terms of possible types of research questions, empirical contexts, and methods for data collection and analysis. This includes how we are planning to use positioning theory (Harré & van Langenhove, 1999) to explore emotional scaffolding in ESE in the context of engineering education. We also explore what types of results could be obtained and how those results could be made useful in and for ESE practice. Expected outcomes: In conclusion, this theoretical contribution seeks to take stock of the current understanding of emotional scaffolding, develop a broader and more theoretically informed definition of emotional scaffolding, and draw out implications for educational research and practice. We argue that emotional scaffolding is conceptualized in a narrow way and remains under-theorized: It fails to recognize the wide range of pedagogical tools and strategies teachers can use to influence a variety of types of students’ emotional responses. Most notably, emotional responses should be broadened to include all four types of academic emotions: topic emotions, achievement emotions, epistemic emotions, and social emotions. Our broadened definition of emotional scaffolding opens up a large array of research questions that should be highly relevant not only for ESE but also for educational research more broadly. References Bossér, U., & Lindahl, M. (2019). Students’ Positioning in the Classroom: a Study of Teacher-Student Interactions in a Socioscientific Issue Context. Research in Science Education, 49, 371-390. Harré, R., & van Langenhove, L. (1999). Positioning Theory: Moral Contexts of Intentional Action. Malden: Blackwell. Lönngren, J. (2017). Wicked Problems in Engineering Education: Preparing Future Engineers to Work for Sustainability. Chalmers University of Technology, Gothenburg. Lönngren, J., Adawi, T., & Svanström, M. (2019). Scaffolding strategies in a rubric-based intervention to promote engineering students’ ability to address wicked problems. European Journal of Engineering Education, 44(1-2), 196-221. McCaughtry, N. (2004). The Emotional Dimensions of a Teacher’s Pedagogical Content Knowledge: Influences on Content, Curriculum, and Pedagogy. Journal of Teaching in Physical Education, 23, 30-47. Meyer, D. K., & Turner, J. C. (2007). Scaffolding Emotions in Classrooms. In P. A. Schutz & R. Pekrun (Eds.), Emotion in Education (pp. 243-258). Cambridge: Academic Press. Ojala, M. (2013). Emotional Awareness: On the Importance of Including Emotional Aspects in Education for Sustainable Development (ESD). Journal of Education for Sustainable Development, 7(2), 167-182. Ojala, M. (2015). Hope in the Face of Climate Change: Associations With Environmental Engagement and Student Perceptions of Teachers’ Emotion Communication Style and Future Orientation. The Journal of Environmental Education, 46(3), 133-148. Park, M.-H. (2016). Emotional Scaffolding as a Strategy to Support Children's Engagement in Instruction. Universal Journal of Educational Research, 4(10), 2353-2358. Abstract till European Conference of Education Research (ECER) 2021 Pekrun, R., & Linnenbrink-Garcia, L. (2012). Academic Emotions and Student Engagement. In S. Christenson, A. Reschly, & C. Wylie (Eds.), Handbook of Research on Student Engagement. Boston: Springer. Rosiek, J. (2003). Emotional Scaffolding: An Exploration of The Teacher Knowledge at the Intersection of Student Emotion and the Subject Matter. Journal of Teacher Education, 54(5), 399-412. van de Pol, J., Volman, M., & Beishuizen, J. (2010). Scaffolding in Teacher-Student Interaction: A Decade of Research. Educational Psychology Review, 22, 271-296. Zembylas, M. (2007). The Power and Politics of Emotions in Teaching. In P. A. Schutz & R. Pekrun (Eds.), Emotion in Education (pp. 293-309). Cambridge: Academic Press.
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| 25. |
- Matsumoto, Taro, et al.
(författare)
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VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.
- 2005
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Ingår i: EMBO J. - 0261-4189. ; 24:13, s. 2342-53
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Tidskriftsartikel (refereegranskat)abstract
- Vascular endothelial growth factor receptor-2 (VEGFR-2) activation by VEGF-A is essential in vasculogenesis and angiogenesis. We have generated a pan-phosphorylation site map of VEGFR-2 and identified one major tyrosine phosphorylation site in the kinase insert (Y951), in addition to two major sites in the C-terminal tail (Y1175 and Y1214). In developing vessels, phosphorylation of Y1175 and Y1214 was detected in all VEGFR-2-expressing endothelial cells, whereas phosphorylation of Y951 was identified in a subset of vessels. Phosphorylated Y951 bound the T-cell-specific adapter (TSAd), which was expressed in tumor vessels. Mutation of Y951 to F and introduction of phosphorylated Y951 peptide or TSAd siRNA into endothelial cells blocked VEGF-A-induced actin stress fibers and migration, but not mitogenesis. Tumor vascularization and growth was reduced in TSAd-deficient mice, indicating a critical role of Y951-TSAd signaling in pathological angiogenesis.
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| 26. |
- Persson, Anders, et al.
(författare)
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Atlanto-axial rotatory subluxations in postmortem CT : radiologists be aware of a common pitfall
- 2013
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Ingår i: Forensic Science International. - : Elsevier. - 0379-0738 .- 1872-6283. ; 225:1-3, s. 9-14
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to determine the frequency of atlanto-axial rotatory subluxations (AARS) in multi detector computed tomography (MDCT) performed on human corpses for forensic purposes and to investigate whether these are a physiological postmortem finding or indicate a trauma to the neck region.80 forensic cases examined with MDCT from November 2003 to March 2007 were included in the study. The study was approved by the regional ethics committee. For each case volumes were rendered and investigated with reference to suspected AARS and any other anomalies of the head and neck region. The rotation of the head as well as in the atlanto-axial joint were measured and occurring AARS were judged according Fielding's classification. The finding of AARS was correlated to case criteria such as postmortem head rotation, sex, age, cause of death, time since death and further autopsy results. Statistical analysis was performed using Fisher's exact test, Wilcoxon's rank sums test and Chi-square test with Pearson approximation.70% (n = 56) of the cases included in the study presented with an AARS. A strong correlation (P < .0001) between suspected AARS and postmortem head rotation was found. Two cases presented with an atlanto-axial rotation greater than the head rotation. One showed an undiscovered lateral dislocation of the atlas, and one an unfused atlas-ring. There was no correlation to any further investigated case criteria. Ipsilateral AARS with head rotation alone does not indicate trauma to the neck.PmCT can substantially support forensic examinations of the skeleton, especially in body regions, which are elaborate to access at autopsy, such as the cervical spine. Isolated AARS (Fielding type I) on pmCT is usually a normal finding associated with ipsilateral head rotation.
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| 27. |
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| 28. |
- Persson, Anders, et al.
(författare)
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Temperature-corrected postmortem 3-T MR quantification of histopathological early acute and chronic myocardial infarction: a feasibility study
- 2018
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Ingår i: International journal of legal medicine. - : SPRINGER. - 0937-9827 .- 1437-1596. ; 132:2, s. 541-549
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Tidskriftsartikel (refereegranskat)abstract
- The goal of the present study was to evaluate if quantitative postmortem cardiac 3-T magnetic resonance (QPMCMR) T1 and T2 relaxation times and proton density values of histopathological early acute and chronic myocardial infarction differ to the quantitative values of non-pathologic myocardium and other histopathological age stages of myocardial infarction with regard to varying corpse temperatures. In 60 forensic corpses (25 female, 35 male), a cardiac 3-T MR quantification sequence was performed prior to autopsy and cardiac dissection. Core body temperature was assessed during MR examinations. Focal myocardial signal alterations in synthetically generated MR images were measured for their T1, T2, and proton density (PD) values. Locations of signal alteration measurements in PMCMR were targeted at heart dissection, and myocardial tissue specimens were taken for histologic examinations. Quantified signal alterations in QPMCMR were correlated to their according histologic age stage of myocardial infarction, and quantitative values were corrected for a temperature of 37 A degrees C. In QPMCMR, 49 myocardial signal alterations were detected in 43 of 60 investigated hearts. Signal alterations were diagnosed histologically as early acute (n = 16), acute (n = 10), acute with hemorrhagic component (n = 9), subacute (n = 3), and chronic (n = 11) myocardial infarction. Statistical analysis revealed that based on their temperature-corrected quantitative T1, T2, and PD values, a significant difference between early acute, acute, and chronic myocardial infarction can be determined. It can be concluded that quantitative 3-T postmortem cardiac MR based on temperature-corrected T1, T2, and PD values may be feasible for pre-autopsy diagnosis of histopathological early acute, acute, and chronic myocardial infarction, which needs to be confirmed histologically.
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| 29. |
- Pinho-Gomes, Ana-Catarina, et al.
(författare)
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Blood pressure-lowering treatment for the prevention of cardiovascular events in patients with atrial fibrillation : An individual participant data meta-analysis
- 2021
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Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 18:6
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Tidskriftsartikel (refereegranskat)abstract
- Background Randomised evidence on the efficacy of blood pressure (BP)-lowering treatment to reduce cardiovascular risk in patients with atrial fibrillation (AF) is limited. Therefore, this study aimed to compare the effects of BP-lowering drugs in patients with and without AF at baseline. Methods and findings The study was based on the resource provided by the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC), in which individual participant data (IPD) were extracted from trials with over 1,000 patient-years of follow-up in each arm, and that had randomly assigned patients to different classes of BP-lowering drugs, BP-lowering drugs versus placebo, or more versus less intensive BP-lowering regimens. For this study, only trials that had collected information on AF status at baseline were included. The effects of BP-lowering treatment on a composite endpoint of major cardiovascular events (stroke, ischaemic heart disease or heart failure) according to AF status at baseline were estimated using fixed-effect one-stage IPD meta-analyses based on Cox proportional hazards models stratified by trial. Furthermore, to assess whether the associations between the intensity of BP reduction and cardiovascular outcomes are similar in those with and without AF at baseline, we used a meta-regression. From the full BPLTTC database, 28 trials (145,653 participants) were excluded because AF status at baseline was uncertain or unavailable. A total of 22 trials were included with 188,570 patients, of whom 13,266 (7%) had AF at baseline. Risk of bias assessment showed that 20 trials were at low risk of bias and 2 trials at moderate risk. Meta-regression showed that relative risk reductions were proportional to trial-level intensity of BP lowering in patients with and without AF at baseline. Over 4.5 years of median follow-up, a 5-mm Hg systolic BP (SBP) reduction lowered the risk of major cardiovascular events both in patients with AF (hazard ratio [HR] 0.91, 95% confidence interval [CI] 0.83 to 1.00) and in patients without AF at baseline (HR 0.91, 95% CI 0.88 to 0.93), with no difference between subgroups. There was no evidence for heterogeneity of treatment effects by baseline SBP or drug class in patients with AF at baseline. The findings of this study need to be interpreted in light of its potential limitations, such as the limited number of trials, limitation in ascertaining AF cases due to the nature of the arrhythmia and measuring BP in patients with AF. Conclusions In this meta-analysis, we found that BP-lowering treatment reduces the risk of major cardiovascular events similarly in individuals with and without AF. Pharmacological BP lowering for prevention of cardiovascular events should be recommended in patients with AF. Author summary Why was this study done? Atrial fibrillation (AF) is the most common cardiac arrhythmia across the world and is strongly associated with future vascular disease, particularly stroke. Blood pressure (BP) lowering is an established strategy for prevention of vascular disease, but whether patients with AF benefit similarly from pharmacological BP reduction is not well understood. What did the researchers do and find? We compared the preventive effect of BP-lowering treatment on cardiovascular outcomes in patients with and without AF at baseline. We conducted an individual participant data meta-analysis using published and unpublished data from large randomised clinical trials (22 trials involving 188,570 patients). We showed that BP-lowering treatment reduced the risk of a major cardiovascular events with no evidence that effects differed according to the presence or absence of AF at baseline. The relative risk reductions were proportional to the intensity of BP reduction in individuals with and without AF. In individuals with AF, the relative risk reduction was comparable irrespective of whether baseline systolic BP was under or over the conventional treatment threshold of 140 mm Hg. What do these findings mean? BP-lowering treatment reduces the risk of major cardiovascular events in patients with AF to a similar extent to that of patients without AF. Pharmacological BP-lowering treatment for prevention of cardiovascular events should be recommended as part of care for patients with AF.
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| 30. |
- Rivard, Léna, et al.
(författare)
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Atrial Fibrillation and Dementia : A Report From the AF-SCREEN International Collaboration
- 2022
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Ingår i: Circulation. - 1524-4539. ; 145:5, s. 392-409
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Forskningsöversikt (refereegranskat)abstract
- Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration summarizes the evidence linking AF to cognitive impairment and dementia. It provides guidance on the investigation and management of dementia in patients with AF on the basis of best available evidence. The document also addresses suspected pathophysiologic mechanisms and identifies knowledge gaps for future research. Whereas AF and dementia share numerous risk factors, the association appears to be independent of these variables. Nevertheless, the evidence remains inconclusive regarding a direct causal effect. Several pathophysiologic mechanisms have been proposed, some of which are potentially amenable to early intervention, including cerebral microinfarction, AF-related cerebral hypoperfusion, inflammation, microhemorrhage, brain atrophy, and systemic atherosclerotic vascular disease. The mitigating role of oral anticoagulation in specific subgroups (eg, low stroke risk, short duration or silent AF, after successful AF ablation, or atrial cardiopathy) and the effect of rhythm versus rate control strategies remain unknown. Likewise, screening for AF (in cognitively normal or cognitively impaired patients) and screening for cognitive impairment in patients with AF are debated. The pathophysiology of dementia and therapeutic strategies to reduce cognitive impairment warrant further investigation in individuals with AF. Cognition should be evaluated in future AF studies and integrated with patient-specific outcome priorities and patient preferences. Further large-scale prospective studies and randomized trials are needed to establish whether AF is a risk factor for cognitive impairment, to investigate strategies to prevent dementia, and to determine whether screening for unknown AF followed by targeted therapy might prevent or reduce cognitive impairment and dementia.
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| 31. |
- Salam, Abdul, et al.
(författare)
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Effects of blood pressure lowering on cardiovascular events, in the context of regression to the mean : a systematic review of randomized trials
- 2019
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 37:1, s. 16-23
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Forskningsöversikt (refereegranskat)abstract
- Objective: To assess the clinical relevance of regression to the mean for clinical trials and clinical practice. Methods: MEDLINE was searched until February 2018 for randomized trials of BP lowering with over 1000 patient-years follow-up per group. We estimated baseline mean BP, follow-up mean (usual) BP amongst patients grouped by 10 mmHg strata of baseline BP, and assessed effects of BP lowering on coronary heart disease (CHD) and stroke according to these BP levels. Results: Eighty-six trials (349 488 participants), with mean follow-up of 3.7 years, were included. Most mean BP change was because of regression to the mean rather than treatment. At high baseline BP levels, even after rigorous hypertension diagnosis, downwards regression to the mean caused much of the fall in BP. At low baseline BP levels, upwards regression to the mean increased BP levels, even in treatment groups. Overall, a BP reduction of 6/3 mmHg lowered CHD by 14% (95% CI 11-17%) and stroke by 18% (15-22%), and these treatment effects occurred at follow-up BP levels much closer to the mean than baseline BP levels. In particular, more evidence was available in the SBP 130-139 mmHg range than any other range. Benefits were apparent in numerous high-risk patient groups with baseline mean SBP less than 140 mmHg. Conclusion: Clinical practice should focus less on pretreatment BP levels, which rarely predict future untreated BP levels or rule out capacity to benefit from BP lowering in high cardiovascular risk patients. Instead, focus should be on prompt, empirical treatment to maintain lower BP for those with high BP and/or high risk.
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| 32. |
- Vergouwen, Daphne P. C., et al.
(författare)
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The enigma of sclera-specific autoimmunity in scleritis
- 2024
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Ingår i: Journal of Autoimmunity. - : Elsevier. - 0896-8411 .- 1095-9157. ; 144
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Tidskriftsartikel (refereegranskat)abstract
- Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
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| 33. |
- Vinnervik, Peter, 1971-
(författare)
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När lärare formar ett nytt ämnesinnehåll : intentioner, förutsättningar och utmaningar med att införa programmering i skolan
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In March 2017, programming was introduced in the Swedish school curriculum. The reform was formally enacted in July 2018. Research shows that teachers enacting curriculum reform practices encounter various challenges. For this particular reform, few teachers had prior experience of programming, and research further suggests that programming is difficult to teach and learn. It is therefore important to study teachers’ perceptions and experiences of what they should teach, why, and how, as this can provide valuable insight into how new policies influence teachers’ work, and how new policies are implemented.This thesis explores circumstances that may influence teachers’ integration of programming in school mathematics and technology education and consists of three studies. Study 1 and 3 draw on teachers’ perceptions and experiences collected before and after formal enactment of the reform. Study 2 draws on textual data from formal curriculum documents. The studies address three questions: (1) What challenges do teachers perceive prior to the introduction of programming? (2) What message about programming is communicated in the intended curriculum? (3) How do teachers transform programming into teaching content in technology education and what challenges do they face?The results show that teachers face several intrinsic and extrinsic challenges during the process of integrating programming in their teaching. A perceived lack of professional knowledge and understanding of programming among the teachers emerged as a prominent challenge both prior to and more than two years into the reform. Additional challenges are related to teaching materials, time for preparation and professional development. In technology education, teachers mainly see programming as a medium to explore and understand technological systems and construction work. They are uncertain of what programming means in terms of practices and concepts, and about learning progression and assessment. The results further reveal that the curriculum texts are sparse on details about what programming knowledge entails. Important strategic decisions are left entirely to the teachers without any clear guidance. In addition, the results indicate that many technology teachers work in isolation and that interdisciplinary work around programming, as intended in the curriculum, is generally lacking. It is concluded that there is a risk of inequality among schools and that the children’s experience of programming becomes fragmented, despite good intentions. The current implementation model needs to be improved, and this thesis presents two possible actions.
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| 34. |
- Aad, G., et al.
(författare)
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- 2011
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Tidskriftsartikel (refereegranskat)
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| 35. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 36. |
- Aad, G., et al.
(författare)
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- 2012
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Ingår i: Nuclear Physics, Section B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 864:3, s. 341-381
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Tidskriftsartikel (refereegranskat)
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