| 1. |
- Ackeret, Nadja, et al.
(författare)
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Six-month stability of individual differences in sports coaches’ burnout, self-compassion and social support
- 2022
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Ingår i: Psychology of Sport And Exercise. - : Elsevier. - 1469-0292 .- 1878-5476. ; 61, s. 237-
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Tidskriftsartikel (refereegranskat)abstract
- Using a three-wave prospective cross-lagged panel design, the study examined six-month stability of burnout, self-compassion and social support among sports coaches in terms of measurement invariance, mean-level change, rank-order stability, and structural stability. The participating coaches (N = 422; Mage = 44.48, SD = 11.03) completed an online questionnaire measuring self-compassion, social support, coach burnout and demographics at baseline and two follow-ups at three months and six months. The various forms of stability were assessed using structural equation modeling. There was no significant mean-level change in burnout, self-compassion, or social support, and all three constructs exhibited measurement invariance. Rank-order stability remained relatively high, ranging from 0.78 to 0.94 across the three time points. For all three constructs, covariances between latent factors were invariant over time, indicating high structural stability. While self-compassion and social support were positively related, both were negatively related to coach burnout. These results confirm the importance of preventing and addressing symptoms of burnout, low self-compassion and poor social support in sports settings.
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| 2. |
- Berger, Christian, 1980, et al.
(författare)
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Bridging Physical and Digital Traffic System Simulations with the Gulliver Test-Bed
- 2013
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Ingår i: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783642379734 ; 7865 LNCS, s. 169-184
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Konferensbidrag (refereegranskat)abstract
- We propose a cyber-physical platform that combines road traffic simulation, network simulation, and physically simulated vehicles to facilitate extensive testing on various levels of vehicular systems. Our design integrates physical and digital vehicle simulation into a common development and testing environment. This paper describes the platform design and presents prototypical implementations that use Simulator of Urban Mobility (SUMO), TinyOS Simulator (TOSSIM), a 3D sensor simulation environment, and a test-bed of miniature vehicles called Gulliver. As a prototypical implementation, we demonstrate the development of cooperative applications, and by that we achieve: (a) a cyber-physical system that provides a common environment for physically and digitally simulated vehicles, (b) a platform to interface communication between physically and digitally simulated vehicles, and (c) the ability to tailor testing scenarios in which some system components are simulated digitally and some physically. The suggested design provides flexibility, cost efficiency, and scalable testing opportunities for future vehicular systems. Furthermore, the proposed system is able to support novel steps towards intelligent transportation systems for smart cities. © 2013 Springer-Verlag.
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| 3. |
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| 4. |
- Loza, M. J., et al.
(författare)
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Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
- 2016
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Ingår i: Respiratory Research. - : Springer Nature. - 1465-9921 .- 1465-993X. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to define and validate, for the first time ever, clinically driven asthma phenotypes using two independent, severe asthma cohorts: ADEPT and U-BIOPRED. Methods: Fuzzy partition-around-medoid clustering was performed on pre-specified data from the ADEPT participants (n = 156) and independently on data from a subset of U-BIOPRED asthma participants (n = 82) for whom the same variables were available. Models for cluster classification probabilities were derived and applied to the 12-month longitudinal ADEPT data and to a larger subset of the U-BIOPRED asthma dataset (n = 397). High and low type-2 inflammation phenotypes were defined as high or low Th2 activity, indicated by endobronchial biopsies gene expression changes downstream of IL-4 or IL-13. Results: Four phenotypes were identified in the ADEPT (training) cohort, with distinct clinical and biomarker profiles. Phenotype 1 was "mild, good lung function, early onset", with a low-inflammatory, predominantly Type-2, phenotype. Phenotype 2 had a "moderate, hyper-responsive, eosinophilic" phenotype, with moderate asthma control, mild airflow obstruction and predominant Type-2 inflammation. Phenotype 3 had a "mixed severity, predominantly fixed obstructive, non-eosinophilic and neutrophilic" phenotype, with moderate asthma control and low Type-2 inflammation. Phenotype 4 had a "severe uncontrolled, severe reversible obstruction, mixed granulocytic" phenotype, with moderate Type-2 inflammation. These phenotypes had good longitudinal stability in the ADEPT cohort. They were reproduced and demonstrated high classification probability in two subsets of the U-BIOPRED asthma cohort. Conclusions: Focusing on the biology of the four clinical independently-validated easy-to-assess ADEPT asthma phenotypes will help understanding the unmet need and will aid in developing tailored therapies. Trial registration:NCT01274507(ADEPT), registered October 28, 2010 and NCT01982162(U-BIOPRED), registered October 30, 2013.
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| 5. |
- Reis, Edimara S., et al.
(författare)
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Safety profile after prolonged C3 inhibition
- 2018
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Ingår i: Clinical Immunology. - : Elsevier BV. - 1521-6616 .- 1521-7035. ; 197, s. 96-106
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Tidskriftsartikel (refereegranskat)abstract
- The central component of the complement cascade, C3, is involved in various biological functions, including opsonization of foreign bodies, clearance of waste material, activation of immune cells, and triggering of pathways controlling development. Given its broad role in immune responses, particularly in phagocytosis and the clearance of microbes, a deficiency in complement C3 in humans is often associated with multiple bacterial infections. Interestingly, an increased susceptibility to infections appears to occur mainly in the first two years of life and then wanes throughout adulthood. In view of the well-established connection between C3 deficiency and infections, therapeutic inhibition of complement at the level of C3 is often considered with caution or disregarded. We therefore set out to investigate the immune and biochemical profile of non-human primates under prolonged treatment with the C3 inhibitor compstatin (Cp40 analog). Cynomolgus monkeys were dosed subcutaneously with Cp40, resulting in systemic inhibition of C3, for 1 week, 2 weeks, or 3 months. Plasma concentrations of both C3 and Cp40 were measured periodically and complete saturation of plasma C3 was confirmed. No differences in hematological, biochemical, or immunological parameters were identified in the blood or tissues of animals treated with Cp40 when compared to those injected with vehicle alone. Further, skin wounds showed no signs of infection in those treated with Cp40. In fact, Cp40 treatment was associated with a trend toward accelerated wound healing when compared with the control group. In addition, a biodistribution study in a rhesus monkey indicated that the distribution of Cp40 in the body is associated with the presence of C3, concentrating in organs that accumulate blood and produce C3. Overall, our data suggest that systemic C3 inhibition in healthy adult non-human primates is not associated with a weakened immune system or susceptibility to infections.
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