| 1. |
- Berglund, Eva Caroline, et al.
(författare)
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A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias
- 2022
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Ingår i: Frontiers in Medicine. - Lausanne, Switzerland : Frontiers Media SA. - 2296-858X. ; 9, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Genomic Medicine Sweden, aims to evaluate whether combined application of WGS and WTS (WGTS) is technically feasible and can be implemented as an efficient diagnostic tool in patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In addition to clinical impact assessment, a health-economic evaluation of such strategy will be performed. Methods and Analysis: The study comprises four phases (i.e., retrospective, prospective, real-time validation, and follow-up) including approximately 700 adult and pediatric Swedish AML and ALL patients. Results of WGS for tumor (90×) and normal/germline (30×) samples as well as WTS for tumors only will be compared to current standard of care diagnostics. Primary study endpoints are diagnostic efficiency and improved diagnostic yield. Secondary endpoints are technical and clinical feasibility for routine implementation, clinical utility, and health-economic impact. Discussion: Data from this national multi-center study will be used to evaluate clinical performance of the integrated WGTS diagnostic workflow compared with standard of care. The study will also elucidate clinical and health-economic impacts of a combined WGTS strategy when implemented in routine clinical care. Clinical Trial Registration: [https://doi.org/10.1186/ISRCTN66987142], identifier [ISRCTN66987142].
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| 2. |
- Engström, Gunnar, et al.
(författare)
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The Swedish CArdioPulmonary BioImage Study : objectives and design
- 2015
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 278:6, s. 645-659
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Tidskriftsartikel (refereegranskat)abstract
- Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.
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| 4. |
- Almefelt, Lars, 1968, et al.
(författare)
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Requirements management in practice: findings from an empirical study in the automotive industry
- 2006
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Ingår i: Research in Engineering Design. ; 17:3, s. 113-134
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an empirical study carried out in the automotive industry, with the aim to bring forward new experiences and knowledge on management of requirements in practice. Adopting a qualitative systems approach, and using multiple information sources, the requirements management process during the development of a passenger car cockpit has been mapped out. More specifically, the intention has been to identify and describe progress, changes, deviations, and compromises regarding the requirements and their fulfilment linked to the different phases of the product development. The logical reconstruction of the requirements management process is complemented with broad descriptions of associated phenomena, such as important events, organisational structures, competences, and attitudes. Findings are presented, analysed and discussed considering also factors underlying observed phenomena. Accompanying the empirical findings, the paper concludes with recommendations for constructive and efficient requirements management in practice.
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| 5. |
- Berglund, Erik, et al.
(författare)
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Effects of apixaban compared with warfarin as gain in event-free time : a novel assessment of the results of the ARISTOTLE trial
- 2020
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 27:12, s. 1311-1319
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A novel approach to determine the effect of a treatment is to calculate the delay of event, which estimates the gain of event-free time. The aim of this study was to estimate gains in event-free time for stroke or systemic embolism, death, bleeding events, and the composite of these events, in patients with atrial fibrillation randomized to either warfarin or apixaban in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial (ARISTOTLE).DESIGN: The ARISTOTLE study was a randomized double-blind trial comparing apixaban with warfarin.METHODS: Laplace regression was used to estimate the delay in time to the outcomes between the apixaban and the warfarin group in 6, 12, 18 and 22 months of follow-up.RESULTS: The gain in event-free time for apixaban versus warfarin was 181 (95% confidence interval 76 to 287) days for stroke or systemic embolism and 55 (-4 to 114) days for death after 22 months of follow-up. The corresponding gains in event-free times for major and intracranial bleeding were 206 (130 to 281) and 392 (249 to 535) days, respectively. The overall gain for the composite of all these events was a gain of 116 (60 to 171) days.CONCLUSIONS: In patients with atrial fibrillation, 22 months of treatment with apixaban, as compared with warfarin, provided gains of approximately 6 months in event-free time for stroke or systemic embolism, 7 months for major bleeding and 13 months for intracranial bleeding.
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| 6. |
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| 7. |
- Berglund, Lars, 1964-
(författare)
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Arde Fillis / Isti sunt : a contrafactum by Gustav Düben based on a madrigal by Stefano Landi, and previously attributed to Giacomo Carissimi
- 2020
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Ingår i: Contrafacta. Modes of Music Re-textualization in the Late Sixteenth and Seventeenth Century. - Krakow : Musica Iagellonica. - 9788370992392 ; , s. 187-208
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Bokkapitel (refereegranskat)abstract
- A Düben collection manuscript with the shelf number Vmhs 11:2 contains a com-position ascribed to Giacomo Carissimi, with the text incipit Isti sunt triumphatores. The attribution to Carissimi has been regarded as uncertain, but it is still included in several work catalogues. This article shows that the attribution is certainly false. The piece is a re-texted version of a madrigal composed by Stefano Landi, included in his first collection of madrigals, printed in Venice 1619. The title of the original madrigal is “Arde Filli d’un viso”. The text is a poem by Matteo Piacentini published first in Vicenza in 1600, and then again in Venice in 1611, but in Landi’s madrigal the text is modified, or likely misread; the title of the original poem is “Arde Fillide in viso”.The Vmhs 11:2 manuscript in Uppsala contains a complete set of partbooks of two madrigals for five voices, the one by Stefano Landi, and Galeazzo Sabbatini’s “Io amo che tanto basta”. They were prepared by the young Gustav Düben in the early 1650s, perhaps originally intended for instrumental performance. At a later moment, prob-ably after 1663, Düben started to prepare a contrafactum of Landi’s madrigal, using a Latin liturgical text, Isti sunt triumphatores. The text appears to have been borrowed from a printed collection of motets by Gasparo Casati, in that case most likely from the Antwerp reprint published by Marie and Madeleine Phalèse. Liturgically, the text is associated with the Feasts of Apostles, and the contrafactum could possibly have been intended for such a service in the German Church in Stockholm, where Gustav Düben was the organist. It was most likely at this point that Düben misattributed the piece to Carissimi, perhaps associating the manuscript with the time when an en-semble of Italian singers visited the Swedish court between 1652 and 1654, bringing with them a large number of works by Carissimi.The contrafactum is not completed. Only the first thirty-seven bars of the canto primo part have text underlay, and eleven bars of the alto. Since the Latin text was very dif-ferent than the Italian madrigal text, both regarding meter and content, the re-texting involved a number of challenges. In the preserved part, a number of modifications have been made to the music, which is typical of re-texting practices. The melismatic passage opening the madrigal has been set syllabically in the contrafactum, thus annihi-lating the word painting in the original. Notes have been split in two to accommodate the text, or on the contrary joined in melismas. The attempt at a re-texting does not seem very successful, and it is possible that Düben abandoned the task for this reason, even though such an assumption must remain tentative.
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| 17. |
- Berglund, Lars, 1964-
(författare)
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Italian Music in the Düben Collection
- 2017
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Ingår i: Musicologica Istropolitana. - Bratislava. - 1337-9070. ; :13, s. 147-167
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Tidskriftsartikel (refereegranskat)abstract
- The Düben Collection in Uppsala contains many unique compositions and a rela-tively large share of Italian music. About a third of the composers represented in the collection are Italian, and their music constitutes about a sixth of the 2200 com-positions. In the article, a survey of the Italian music is presented and the routes of dissemination are traced. A large share of the compositions by Italian composers have been copied from prints into manuscripts. Some of the prints are still in the Düben Collection, others must have been available to Gustav Düben at some point. As much as half of the Italian compositions belong to this category. There is also a relatively large share of pieces that reached Stockholm in manuscripts, but were originally copied from prints on the Continent – in some cases perhaps even in several steps of manuscript dissemination.The numbers of works that reached Sweden through manuscript dissemination only, never having appeared in print, is comparatively small but important, since this group contains several unique Italian works and manuscripts with an interesting dissemination history. About fifteen such manuscripts travelled to Sweden with an ensemble of Italian singers and musicians recruited to the court of Queen Christina in 1652, with Vincenzo Albrici as maestro di cappella. In addition, there are thirty-six manuscripts copied by Gustav Düben and his helpers. This group of manuscripts contains unique works by, for example, Giacomo Carissimi and Francsco Foggia.Two case studies shed light on the complexity of dissemination routes in the case of the Düben Collection. The ten compositions each by Simone Vesi and Gio-vanni Carisio reached Sweden in different ways: they were copied from prints, aquired in manuscript via Lübeck or Hamburg, and via Danzig. Some works have been re-texted and adapted for local purposes.The case of Italian music in the Düben Collection illustrates the complexity of the collection and its routes of dissemination and the necessity to scrutinize and contextualize every single manuscript.
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| 18. |
- Berglund, Lars, 1964-
(författare)
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Kaspar Förster Jun. (1616–1673): Sacrae cantiones 1, 2, & 3 vocuum
- 2021
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Bok (refereegranskat)abstract
- A critical edition of 12 concertato motets for 1 to 3 voices by Kaspar Förster jnr (1616-1673). Förster was born in Danzig (Gdansk) and studied in Rome for Giacomo Carissimi in the 1630s. From c. 1637-1652 he was a singer at the Polish court, and from 1652-1667 Hofkapellmeister in Denmark. He died in Oliwa 1673. Förster's music is Italianate in style, with smooth vocal melodies and a sectionalized motet style with a variation of styles and textures. His music is highly expressive, with a harmonic language where he develops the Roman tradition in new direction. He was an important mediator of the new Italian musical style in Northern Europe.
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| 23. |
- Berglund, Lars, 1964-
(författare)
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Mourning a dead Queen. The music at the funeral of Ulrika Eleonora the Elderin Stockholm (1693)
- 2020
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Ingår i: Contrafacta. Modes of Music Re-textualization in the Late Sixteenth and Seventeenth Century. - Krakow : Musica Iagellonica. - 9788370992392 ; , s. 247-263
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Bokkapitel (refereegranskat)abstract
- Ulrika Eleonora the Elder, Queen of Sweden from 1680, died in July 1693. She was buried in the Royal funeral church, Riddarholmskyrkan, on November 28 of the same year. The Queen’s funeral was designed to be one of the most magnificent ceremonies of state in Sweden during the Baroque era. The decorations for the ceremony were created by the Royal court architect, Nicodemus Tessin the Younger (1654–1728). For the Queen’s coffin he built a castrum doloris with a huge black pyramid, covered with emblems and inscriptions painted in a golden colour, which were illuminated by lamps inside the construction. Little or nothing has been known about the music played dur-ing this ceremony. According to the official printed account two musical works were performed. In this article I am able to show that the works referred to consisted of one composition by the French court violinist Pierre Verdier, Kristus är mitt liv, and one by the Flemish composer Daniel Danielis, Aspice e caelis, with a new text in Swedish. This can be shown by means of source and watermark studies and by analysing the texts. The biblical verse on which Verdier’s piece is based (Phil. 1:21: “[for to me,] to live is Christ and to die is gain”), was the Queen’s motto and the text for the funeral sermon. Moreover, Danielis’ Aspice e caelis was originally composed for the funeral of princess Eleonora of Güstrow-Mecklenburg, who was a cousin to Ulrika Eleonora’s husband, the King. That piece has been re-texted with an undoubtedly tailor-made Swedish text, which closely follows the varied rhythm and stress patterns of Danielis’ recitative setting, at the same time mirroring the import and affect of the original text, but not the exact wording. Both works are marked by a sad, plaintive affect appropriate for such an occasion. Both are scored for gamba consort, which at this time was associated with tears and sorrow. In both works we find instances of symbolic, rhetorical personi-fication: in Verdier’s composition the duet between bass and soprano can be associated with the Queen’s tender relation to Christ. In Danielis’ motet the solo soprano voice represents the female gender of the person being buried. Apart from these two works, also a choral arrangement by Christian Ritter, Einen guten Kampf, can be associated with the funeral.The recycling of music for the funeral is not a coincidence, but should be understood as a representation of dynastic continuity. In a similar way, the visual decorations of the funeral were re-used at later royal funerals. There are also indications that Verdier’s Kristus är mitt liv was used again at the funeral of Ulrika Eleonora’s husband King Charles XI in 1697.
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| 29. |
- Berglund, Lars, 1964-
(författare)
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Northern Travellers in Southern Soundscapes : Swedish Musical Tourists in the 17th and 18th Centuries
- 2020
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Ingår i: Turismo Musicale: Storia, Geografia, Didattica. - Bologna : Pàtron editore. - 9788855534970 ; , s. 23-31
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Bokkapitel (refereegranskat)abstract
- Many Swedish noblemen made educational journeys in Europe in the early modern period. These journeys were motivated by notions of nation building, while at the same time they served the social ambitions of the families. I focus on two such journeys: Carl Lilliecrona, travelling around 1640 and Jean Lefebure and Bengt Ferrner around 1760. The examples suggest a shift: whereas Lilliecrona’s journey could be described as an anthropological experience in a musical terra incognita, more than a century later, Lefebure and Ferrner followed a more predetermined course, aiming to conform with now standardized cosmopolitan patterns of taste.
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| 30. |
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| 31. |
- Berglund, Lars, 1964-, et al.
(författare)
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Prelude to an abdication: Italian music and musicians at the Swedish court of Queen Christina, 1652–1654
- 2024
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Ingår i: Svensk tidskrift för musikforskning. - 0081-9816 .- 2002-021X. ; 106
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Tidskriftsartikel (refereegranskat)abstract
- From November 1652 until June 1654, an ensemble of Italian singers and musicians resided at the court of Queen Christina of Sweden, first in Stockholm and thereafter in Uppsala. They performed both secular music at her chambers and sacred music in the church, and also staged theatrical plays at the royal castle. This article presents new information about the recruitment process and the incentives behind it, and a reconstruction of the repertoire of the ensemble and the performance contexts for that repertoire. The ensemble was not an opera troupe, as has repeteadly been asserted in the literature. Instead they were arguably primarily recruited to perform sacred music in a Catholic tradition. The headquarters of the Jesuit Society in Rome was even directly involved in the recruitment of the singers. Thus, the recruitment process went hand in hand with Christina’s plans to abdicate, convert to Catholicism and move to Rome, and must be interpreted as part of that process.
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| 32. |
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| 33. |
- Berglund, Lars, 1964-
(författare)
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Routes to the Düben Collection: The Acquisition of Music by Gustav Düben and his Sons
- 2015
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Ingår i: De musica dissidenda. - Ljubljana : Muzikološki inštitut ZRC SAZU. - 1854-3405. ; 11:1-2, s. 51-66
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Tidskriftsartikel (refereegranskat)abstract
- The article describes the practices of acquisition of music behind the üben Collection. Music was copied into manuscripts from prints, but was also obtained in the form of groups of manuscripts from different regions of Europe. Close personal contacts and networks seem to have been more important than traditional trade routes.
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| 34. |
- Berglund, Lars, 1964-
(författare)
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Studier i Christian Geists vokalmusik
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation is an historical and analytical study of the vocal works of Christian Geist (c1650–1711), composed for the royal Swedish court and for the German church in Gothenburg. Theoretically it draws on the model of genre history advocated by Carl Dahlhaus.The first three chapters deal with Geist’s biography and milieu, the manuscript sources and the uses of his music. The second part deals with Geist’s compositions, and the relation between use, musical design and genre traditions are studied. The compositions are analysed and interpreted as individual solutions to problems in the history of composition, related to questions of genre and to important changes in compositional techniques from around 1650.A typical feature of Geist’s music is a resistance to regular solutions. This is manifested in the reciprocal relation between the use of generic and schematic models on the one hand, and the constant effort to break, differentiate and modify these models. The most individualistic solutions are to be found in his settings of Latin devotional poetry, some of which were composed for royal Communion services. These are designed as clearly sectionalised, stylistically differentiated arias with very strong affect, accomplished mainly by harmonic means. His concertos for regular worship services and solemn occasions stay closer to the norms of the genre. Still, they are marked by the integration of a modern, italianate approach to harmony based on cadence progressions and a regular grouping of phrases, which radically changes the design of the concerto textures.
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| 35. |
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| 36. |
- Berglund, Lars, 1964-
(författare)
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The Establishment of Swedish Musicology
- 2019
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Ingår i: Wege zur Musikwissenschaft / Paths to Musicology. - Kassel : Bärenreiter Verlag. - 9783476046697
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 40. |
- Berglund, Lars, 1964-
(författare)
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Traditionalister och radikala i efterkrigstidstidens svenska musikliv : Kring Jan Carlstedt och hans stråkkvartett nr 2
- 2009
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Ingår i: STM-Online. - 1403-5715. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- During the 1950s and early 1960, the art music scene in Sweden saw a conflict between the advocates of a more traditionalist and moderate modernism on the one hand, and the devotees of radical and experimental music on the other. The most articulate spokesman for the traditionalist camp was the composer Jan Carlstedt (1926–2004), a pupil of Lars Erik Larsson. In my article this historical tension between traditionalists and radicals is analysed using material from newspapers, magazines and not the least the diary of Bo Wallner, a source which gives unique insights in the silent play behind the scenes. It is argued that the opposing fractions to a large extent shared similar aesthetic views, and that the conflicts of opinion was a matter of style rather than fundamental aestetic questions. Moreover the schism was a result of conflicting agendas of a more musico-political kind, the radical camp working to strengthen the position of Swedish music on the international arena.Therafter Jan Carlstedts music aesthetic stance is scrutinized, via his statements about his own music as well as that of his models – especially Sergei Prokofiev and Dmitry Shostakovic. Moreover the practical, compositional consequences of that stance are exemplified through an analysis of his second string quartet (1966), which he himself pointed out as a key work. The ambition to regenerate art music by “giving new meaning to the lasting elements of the musical tradition” turns out to be a central idea in Carlstedt's views on music. In the second quartet this is mainly attempted by unconventional manipulations of a basically traditional harmonical language, taking inspiration from the music by Shostakovic, Bartók and Britten. In this process, he often used different kinds of symmetrical patterning. The harmonic language can at times be quite dissonant, but this is balanced with quite conventional schemes of melody, rhythm and phrase organisation. His musical language is related to that of Shostakovic, but lacks the Russians complex stylistic fractures.
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| 44. |
- Bergström, Göran, 1964, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 45. |
- Boström, Mathias, 1973-
(författare)
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Fonografen som föreställning : Introduktionen av ljudinspelningar vid svenska minnesinstitutioner
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With the invention of the phonograph in 1877 came the possibility to mechanically capture, store and reproduce sound. This thesis deals with how sound recording technology was introduced in memory institutions in Sweden. The focus of the thesis is on the first phonogram format, wax cylinder recordings, and their life cycle in use. This study deals only with memory institutions primarily directed towards Swedish-speaking majority culture, whereas cylinder recordings of the cultural Others will be the subject of a separate publication.The aim of the thesis is to increase the knowledge and enhance the understanding of the archival use of the cylinder phonograph in discourse and practice, with a focus on music recordings. With inspiration taken from a model of knowledge production by Bruno Latour, the study encompasses technology transfer, collecting practices and repertory analysis, institutionalization and professionalization, institutional economics, public presentations, and research practices. The cylinder phonograph was used by ten Swedish memory institutions 1898-1948, primarily by institutions directed towards traditional culture (dialects, folklore, and folk music), and with professional ambitions to some degree. Equipment and knowledge were to a certain extent transferred through professional networks in Sweden, with Danish and German memory institutions as important foreign competence centres. In comparison with some of the neighbouring countries, the introduction of sound recording technology in Sweden was generally some years later and the collections smaller. This is due to that professional memory institutions were founded later in Sweden, and that the collectors and scholars were primarily interested in typical representations of music in notation, rather than the phonogram’s particular representation of a single performance. Sound recording technology was therefore not regarded as a threat in relation to collecting music by ear. It was instead seen as a complement that could also, as objective reference recordings, increase the value of collections made by ear. The use of recording technology did, in several cases, narrow down the collected repertory and the informants that were chosen, due to that quality of performance now became important in a new sense. Few scholars in Sweden asked for archival recordings for research, and the cylinder recordings were not used for public presentations and publications in the period when the technology was in active use. Thus, it is not surprising that the cylinder phonograph did not became an important method for memory institutions in Sweden.
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| 46. |
- Christersson, Christina, et al.
(författare)
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The utility of coagulation activity for prediction of risk of mortality and cardiovascular events in guideline-treated myocardial infarction patients
- 2017
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Ingår i: Upsala Journal of Medical Sciences. - : Taylor & Francis. - 0300-9734 .- 2000-1967. ; 122:4, s. 224-233
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Despite improved treatment of myocardial infarction (MI), real-world patients still suffer substantial risk for subsequent cardiovascular events. Little is known about coagulation activity shortly after MI and whether coagulation activity markers may identify patients at increased risk despite contemporary treatment.OBJECTIVE: To evaluate D-dimer concentration and thrombin generation potential shortly after discharge after MI and evaluate if these markers could predict the risk of future cardiovascular and bleeding events.METHODS: Unselected MI patients (n = 421) were included in the observational REBUS study (NCT01102933) and followed for two years. D-dimer concentrations, thrombin peak, and endogenous thrombin potential (ETP) were analyzed at inclusion (3-5 days after MI) and at early follow-up (after 2-3 weeks).RESULTS: Seventy-five patients (17.8%) experienced the composite endpoint (all-cause death, MI, congestive heart failure, or all-cause stroke), and 31 patients (7.4%) experienced a clinically relevant bleeding event. D-dimer concentrations at early follow-up were associated with the composite endpoint (HR [per SD increase] 1.51 [95% CI 1.22-1.87]) and with clinically relevant bleeding (HR [per SD increase] 1.80 [95% CI 1.32-2.44]). Thrombin generation potential was not significantly associated with either the composite endpoint or with clinically relevant bleeding. Higher thrombin peak and ETP at early follow-up were both inversely associated with stroke (HR [per SD increase] 0.50 [95% CI 0.30-0.81] and 0.43 [95% CI 0.22-0.83], respectively).CONCLUSION: In unselected MI patients treated according to contemporary guidelines, D-dimer measurements may identify patients at increased risk of new cardiovascular and bleeding events. The inverse association of thrombin generation potential and risk of stroke has to be further investigated.
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| 47. |
- Dahlgren, Angelica, et al.
(författare)
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Do Alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study
- 2011
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Ingår i: Alcohol and Alcoholism. - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 46:5, s. 509-513
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The TaqIA polymorphism of the dopamine D2 receptor (DRD2) gene has been extensively studied in relation to alcoholism, and the TaqI A1 allele appears to be over-represented in alcohol-dependent individuals. In a recent study, this allele has also been associated with a highly increased mortality rate in alcohol-dependent individuals. In the present study, we investigated whether the TaqI A1 allele of the DRD2 gene region was associated with a higher relapse rate in alcohol-dependent individuals. Methods: Adult women (n = 10) and men (n = 40) with a diagnosis of alcohol-dependence were recruited from two Swedish 12-step treatment units for alcoholism. Subjects were genotyped for the TaqIA polymorphism. On average, 11/2 year after the end of the treatment program, subjects were re-interviewed by using the alcohol-related items from the Addiction Severity Index follow-up version. Results: Thirty-three (66%) subjects self-reported relapse and 17 (34%) abstinence during the follow-up period. Thirty-sex percent (18/50) were carriers of the A1 allele of the DRD2 gene region, and 64% (32/50) were non-carriers. Among the carriers of the A1 allele, 89% (16/18) reported relapse in contrast to 53% (17/32) in the non-carriers (P = 0.01; odds ratio = 7.1). Conclusion: The present study is, to our knowledge, the first report of an association between the TaqI A1 allele and a substantially increased relapse rate. It should be emphasized that the number of subjects is relatively small, and this investigation should therefore be considered as a pilot study. © The Author 2011. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved.
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| 49. |
- Jönelid, Birgitta, et al.
(författare)
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Low Walking Impairment Questionnaire score after a recent myocardial infarction identifies patients with polyvascular disease
- 2019
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Ingår i: JRSM Cardiovascular Disease. - : SAGE Publications. - 2048-0040. ; 8, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To evaluate whether the Walking Impairment Questionnaire score could identify patients with polyvascular disease in a population with recent myocardial infarction and their association with cardiovascular events during two-year follow-up.Design: A prospective observational study.Setting: Patients admitted to the acute coronary care unit, the Department of Cardiology, Uppsala University Hospital.Participants: Patients admitted with acute Non-STEMI- or STEMI-elevation myocardial infarction.Main outcome measures: The Walking Impairment Questionnaire, developed as a self-administered instrument to assess walking distance, speed, and stair climbing in patients with peripheral artery disease, predicts future cardiovascular events and mortality. Two hundred and sixty-three patients with recent myocardial infarction answered Walking Impairment Questionnaire. Polyvascular disease was defined as abnormal findings in the coronary- and carotid arteries and an abnormal ankle-brachial index. The calculated score for each of all three categories were divided into quartiles with the lowest score in first quartile.Results: The lowest (worst) quartile in all three Walking Impairment Questionnaire categories was associated with polyvascular disease, fully adjusted; distance, odds ratio (OR) 5.4 (95% confidence interval (CI) 1.8-16.1); speed, OR 7.4 (95% CI 1.5-36.5); stair climbing, OR 8.4 (95% CI 1.0-73.6). In stair climbing score, patients with the lowest (worst) score had a higher risk for the composite cardiovascular endpoint compared to the highest (best) score; hazard ratio 5.3 (95% CI 1.5-19.0). The adherence to medical treatment was high (between 81.7% and 99.2%).Conclusions: The Walking Impairment Questionnaire is a simple tool to identify myocardial infarction patients with more widespread atherosclerotic disease and although well treated medically, stair climbing predicts cardiovascular events.
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- Källström, Miikka, et al.
(författare)
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Effects of sauna bath on heart failure : A systematic review and meta-analysis
- 2018
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 41:11, s. 1491-1501
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND:Sauna bath has potential as a lifestyle treatment modality for heart failure (HF). It is important to analyze the current evidence to help suggest paths of future study and potential for clinical application.HYPOTHESIS:Sauna bath has a positive effect on HF patients.METHODS:PubMed, Cochrane Library, and CINAHL databases were searched to identify randomized and nonrandomized controlled studies to compare effects of sauna bath with no sauna bath. Studies were searched for both infrared sauna bath and Finnish sauna bath. The strength of evidence was rated using a modified GRADE approach. Out of 1444 studies, nine met the inclusion criteria and were included in this review. Seven of these nine studies were included in the meta-analysis. Only studies with infrared sauna bath met the inclusion criteria.RESULTS:In the meta-analysis, exposure to an infrared sauna bath in 60°C for 15 minutes, followed by a 30-minute rest in warm environment, five times a week for 2 to 4 weeks, was associated with a significant reduction in B-type natriuretic peptide, cardiothoracic ratio, and an improvement in left-ventricular ejection fraction. There was no significant effect on left-ventricular end-diastolic diameter, left atrial diameter, systolic blood pressure, or diastolic blood pressure. The strength of evidence varied from moderate to insufficient.CONCLUSION:Infrared sauna bath was associated with short-term improvement in cardiac function. More evidence is needed about long-term effects of sauna bath and the effects of a Finnish sauna on cardiovascular health among patients with HF or other cardiovascular diseases.
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