| 1. |
- Andersson, Claes, et al.
(författare)
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Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
- 2020
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models and induces ERK signalling. In the present study we investigated whether MBZ induced ERK activation is shared by other tubulin binding agents (TBAs) and if it is observable also in other human cell types. Curated gene signatures for a panel of TBAs in the LINCS Connectivity Map (CMap) database showed a unique strong negative correlation of MBZ with MEK/ERK inhibitors indicating ERK activation also in non-haematological cell lines. L1000 gene expression signatures for MBZ treated THP-1 monocytes also connected negatively to MEK inhibitors. MEK/ERK phosphoprotein activity testing of a number of TBAs showed that only MBZ increased the activity in both THP-1 monocytes and PMA differentiated macrophages. Distal effects on ERK phosphorylation of the substrate P90RSK and release of IL1B followed the same pattern. The effect of MBZ on MEK/ERK phosphorylation was inhibited by RAF/MEK/ERK inhibitors in THP-1 models, CD3/IL2 stimulated PBMCs and a MAPK reporter HEK-293 cell line. MBZ was also shown to increase ERK activity in CD4+ T-cells from lupus patients with known defective ERK signalling. Given these mechanistic features MBZ is suggested suitable for treatment of diseases characterized by defective ERK signalling, notably difficult to treat autoimmune diseases.
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| 2. |
- Blom, Kristin, et al.
(författare)
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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
- 2019
-
Ingår i: BMC Research Notes. - : Springer Nature. - 1756-0500. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. In the present study we investigated the potential role of protein kinases in mediating this effect.Results: MBZ potently binds and inhibits Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) with a Kd and an IC50 of 7 and 360 nM, respectively. The specific DYRK1B inhibitor AZ191 did not mimic the cytokine release profile of MBZ in untreated THP-1 monocytes. However, in THP-1 cells differentiated into macrophages, AZ191 strongly induced a pro-inflammatory cytokine release pattern similar to MBZ and LPS/IFNγ. Furthermore, like MBZ, AZ191 increased the expression of the M1 marker CD80 and decreased the M2 marker CD163 in THP-1 macrophages. In this model, AZ191 also increased phospho-ERK activity although to a lesser extent compared to MBZ. Taken together, the results demonstrate that DYRK1B inhibition could, at least partly, recapitulate immune responses induced by MBZ. Hence, DYRK1B inhibition induced by MBZ may be part of the mechanism of action to switch M2 to M1 macrophages.
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| 3. |
- Blom, Kristin, et al.
(författare)
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The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation
- 2017
-
Ingår i: Immunopharmacology and immunotoxicology. - : Informa UK Limited. - 0892-3973 .- 1532-2513. ; 39:4, s. 199-210
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Tidskriftsartikel (refereegranskat)abstract
- Mebendazole (MBZ), a drug commonly used for helminitic infections, has recently gained substantial attention as a repositioning candidate for cancer treatment. However, the mechanism of action behind its anticancer activity remains unclear. To address this problem, we took advantage of the curated MBZ-induced gene expression signatures in the LINCS Connectivity Map (CMap) database. The analysis revealed strong negative correlation with MEK/ERK1/2 inhibitors. Moreover, several of the most upregulated genes in response to MBZ exposure were related to monocyte/macrophage activation. The MBZ-induced gene expression signature in the promyeloblastic HL-60 cell line was strongly enriched in genes involved in monocyte/macrophage pro-inflammatory (M1) activation. This was subsequently validated using MBZ-treated THP-1 monocytoid cells that demonstrated gene expression, surface markers and cytokine release characteristic of the M1 phenotype. At high concentrations MBZ substantially induced the release of IL-1 beta and this was further potentiated by lipopolysaccharide (LPS). At low MBZ concentrations, cotreatment with LPS was required for MBZ-stimulated IL-1 beta secretion to occur. Furthermore, we show that the activation of protein kinase C, ERK1/2 and NF-kappaB were required for MBZ-induced IL-1 release. MBZ-induced IL-1 release was found to be dependent on NLRP3 inflammasome activation and to involve TLR8 stimulation. Finally, MBZ induced tumor-suppressive effects in a coculture model with differentiated THP-1 macrophages and HT29 colon cancer cells. In summary, we report that MBZ induced a pro-inflammatory (M1) phenotype of monocytoid cells, which may, at least partly, explain MBZ's anticancer activity observed in animal tumor models and in the clinic.
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| 4. |
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| 5. |
- Hjerpe, Karin, et al.
(författare)
-
Utsläpp av växthusgaser från torvmark
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Dikad torvmark i Sverige avgav sammanlagt drygt 11,4 miljoner ton koldioxidekvivalenter år 2012, enligt den senaste klimatrapporteringen. Denna mängd kan jämföras med de totala svenska utsläppen av växthusgaser, som beräknades uppgå till 57,6 miljoner ton koldioxidekvivalenter samma år. En åtgärd som skulle kunna minska utsläppen av växthusgaser från dikad torvmark är att återställa marken till våtmark, vilket minskar avgången av koldioxid och lustgas från marken. Samtidigt ökar avgången av metan, men minskningen av koldioxid- och lustgasutsläppen är större, vilket innebär att utsläppen av växthusgaser från marken totalt sett minskar. Om de ekonomiska resurserna för att återställa dikad torvmark till våtmark är begränsade bör man i första hand återställa dikade torvmarker som är stora källor för växthusgaser till våtmark. Studier av växthusgasutsläpp från dikade torvmarker som används för skogsproduktion visar att näringsrika och väldränerade marker är större källor för växthusgaser än näringsfattigare, fuktigare marker. Vi bedömer därför att det ur ett klimatperspektiv är viktigast att återställa dikad skogsmark med en kol:kväve-kvot under 25 som är frisk-fuktig eller torrare. Dikad torvmark som används för naturbete avger mindre växthusgaser än åkermark på dikad torvmark och därför är det viktigare att återställa åkermark till våtmark. Avgången av växthusgaser varierar mycket mellan olika åkrar på dikad torvmark. Det är dock inte möjligt att identifiera åkrar på dikad torvmark som är stora källor för växthusgaser utifrån markfuktighet eller kol:kväve-kvot, och inte heller utifrån några andra faktorer som är enkla att mäta. Detta beror sannolikt på att åkermarken generellt är så pass väldränerad och näringsrik att varken syreeller kvävetillgången är begränsande för avgången av koldioxid och lustgas. I ett längre tidsperspektiv kommer dikad torvmark att avge koldioxid och lustgas så länge det finns ett syresatt torvlager. Därför bedömer vi att det är viktigast att återställa dikad åkermark med tjockt torvlager till våtmark. Därtill bör mark som inte längre aktivt brukas prioriteras framför mark som fortfarande är i bruk. Utsläppen av växthusgaser verkar inte automatiskt minska när brukandet upphör och även om marken sannolikt kommer att försumpas på sikt, vilket innebär att utsläppen av växthusgaser minskar, kan det ta väldigt lång tid. Dessutom borde kostnaderna för att återställa marken till våtmark i genomsnitt bli lägre om marken inte längre används. Hur mycket avgången av växthusgaser minskar när dikad torvmark återställs till våtmark beror inte bara på hur stor avgången av växthusgaser från den dikade marken var utan också på hur stor avgången från den anlagda våtmarken blir. Utsläppen från våtmarken påverkas av hur den anläggs och sköts. För att våtmarken ska avge så lite växthusgaser som möjligt bör grundvattennivån höjas så mycket att förhållandena före dikningen återskapas. Om våtmarken anläggs på mark som använts för jordbruksproduktion bör dessutom vegetationen tas bort före återställandet. Anläggning av våtmarker kan också ge andra nyttor – våtmarkerna kan bland annat gynna biologisk mångfald och minska näringsläckaget till våra sjöar och vattendrag. När en våtmark ska anläggas och skötas behöver man ta hänsyn till alla dessa aspekter så att våtmarken ger så stor nytta som möjligt.
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| 6. |
- Jansson, Malin, et al.
(författare)
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Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers
- 2022
-
Ingår i: Frontiers in Molecular Biosciences. - : Frontiers Media SA. - 2296-889X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is the most common cause of cancer death among women worldwide. Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality remains high for tumors that metastasize early. Type IV collagen is a basement membrane protein, and breach of this extracellular matrix structure is the first step of cancer invasion. Type IV collagen is found in the stroma of many cancers, but its role in tumor biology is unclear. Here, expression of type IV collagen in the stroma of small breast cancers was analyzed, correlated to clinically used prognostic biomarkers and patient survival. The findings were further validated in an independent gene expression data cohort. Tissue samples from 1,379 women with in situ and small invasive breast cancers (<= 15 mm) diagnosed in 1986-2004 were included. Primary tumor tissue was collected into tissue microarrays. Type IV collagen expression in tissues was visualized using immunohistochemistry. Gene expression data was extracted from the Cancer Genome Atlas database. Out of 1,379 women, 856 had an invasive breast cancer and type IV collagen staining was available for 714 patients. In Kaplan-Meier analysis high type IV collagen expression was significantly associated (p = 0.026) with poorer breast cancer specific survival. There was no correlation of type IV collagen expression to clinically used prognostic biomarkers. High type IV collagen expression was clearly associated to distant metastasis (p = 0.002). In an external validation cohort (n = 1,104), high type IV collagen mRNA expression was significantly (p = 0.041) associated with poorer overall survival, with overexpression of type IV collagen mRNA in metastatic tissue. Stromal type IV collagen expression in the primary tumor correlates to poor breast cancer specific survival most likely due to a higher risk of developing distant metastasis. This ECM protein may function as biomarker to predict the risk of future metastatic disease in patients with breast cancers.
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| 7. |
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| 8. |
- Jansson, Malin, 1978-, et al.
(författare)
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Stromal type I collagen in breast cancer : correlation to prognostic biomarkers and prediction of chemotherapy response
- 2024
-
Ingår i: Clinical Breast Cancer. - : Elsevier. - 1526-8209 .- 1938-0666.
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Fibrillar collagens accumulate in the breast cancer stroma and appear as poorly defined spiculated masses in mammography imaging. The prognostic value of tissue type I collagen remains elusive in treatment-naïve and chemotherapy-treated breast cancer patients. Here, type I collagen mRNA and protein expression were analysed in 2 large independent breast cancer cohorts. Levels were related to clinicopathological parameters, prognostic biomarkers, and outcome.Method: COL1A1 mRNA expression was analysed in 2509 patients with breast cancer obtained from the cBioPortal database. Type I collagen protein expression was studied by immunohistochemistry in 1395 women diagnosed with early invasive breast cancer.Results: Low COL1A1 mRNA and protein levels correlated with poor prognosis features, such as hormone receptor negativity, high histological grade, triple-negative subtype, node positivity, and tumour size. In unadjusted analysis, high stromal type I collagen protein expression was associated with improved overall survival (OS) (HR = 0.78, 95% CI = 0.61-0.99, p = .043) and trended towards improved breast cancer–specific survival (BCSS) (HR = 0.65, 95% CI = 0.42-1.01, P = 0.053), although these findings were lost after adjustment for other clinical variables. In unadjusted analysis, high expression of type I collagen was associated with better OS (HR = 0.70, 95% CI = 0.55-0.90, P = .006) and BCSS (HR = 0.55, 95% CI = 0.34-0.88, P = .014) among patients not receiving chemotherapy. Strikingly, the opposite was observed among patients receiving chemotherapy. There, high expression of type I collagen was instead associated with worse OS (HR = 1.83, 95% CI = 0.65-5.14, P = .25) and BCSS (HR = 1.72, 95% CI = 0.54-5.50, P = .357).Conclusion: Low stromal type I collagen mRNA and protein expression are associated with unfavourable tumour characteristics in breast cancer. Stromal type I collagen might predict chemotherapy response.
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| 9. |
- Segerman, Anna, et al.
(författare)
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Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
- 2016
-
Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 17:11, s. 2994-3009
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Tidskriftsartikel (refereegranskat)abstract
- Intratumoral heterogeneity is a hallmark of glioblastoma multiforme and thought to negatively affect treatment efficacy. Here, we establish libraries of glioma-initiating cell (GIC) clones from patient samples and find extensive molecular and phenotypic variability among clones, including a range of responses to radiation and drugs. This widespread variability was observed as a continuumof multitherapy resistance phenotypes linked to a proneural-mesenchymal shift in the transcriptome. Multitherapy resistance was associated with a semi-stable cell state that was characterized by an altered DNA methylation pattern at promoter regions of mesenchymal master regulators and enhancers. The gradient of cell states within the GIC compartment constitutes a distinct form of heterogeneity. Our findings may open an avenue toward the development of new therapeutic rationales designed to reverse resistant cell states.
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| 10. |
- Selvin, Tove, et al.
(författare)
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs : an in vitro assessment
- 2024
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Ingår i: BMC Pharmacology & Toxicology. - : BioMed Central (BMC). - 2050-6511. ; 25:1
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundIt has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunological effects of 46 standard anticancer agents and 22 commonly administered concomitant non-cancer drugs.MethodsWe utilized a miniaturized in vitro model system comprised of fluorescently labeled human colon and lung cancer cell lines grown as monocultures and co-cultured with activated peripheral blood mononuclear cells (PBMCs). The Bliss Independence Model was then applied to detect antagonism and synergy between the drugs and activated immune cells.ResultsAmong the standard anticancer agents, tyrosine kinase inhibitors (TKIs) stood out as the top inducers of both antagonism and synergy. Ruxolitinib and dasatinib emerged as the most notably antagonistic substances, exhibiting the lowest Bliss scores, whereas sorafenib was shown to synergize with activated PBMCs. Most concomitant drugs did not induce neither antagonism nor synergy. However, the statins mevastatin and simvastatin were uniquely shown to synergize with activated PBMC at all tested drug concentrations in the colon cancer model.ConclusionWe utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.
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| 11. |
- Selvin, Tove, et al.
(författare)
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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death.
- 2023
-
Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 23:1
-
Tidskriftsartikel (refereegranskat)abstract
- High-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most phenotypic screening platforms used in the field of oncology are based solely on cancer cell populations and do not allow for the identification of immunomodulatory agents.We developed a phenotypic screening platform based on a miniaturized co-culture system with human colorectal cancer- and immune cells, providing a model that recapitulates part of the tumor immune microenvironment (TIME) complexity while simultaneously being compatible with a simple image-based readout. Using this platform, we screened 1,280 small molecule drugs, all approved by the Food and Drug Administration (FDA), and identified statins as enhancers of immune cell-induced cancer cell death.The lipophilic statin pitavastatin had the most potent anti-cancer effect. Further analysis demonstrated that pitavastatin treatment induced a pro-inflammatory cytokine profile as well as an overall pro-inflammatory gene expression profile in our tumor-immune model.Our study provides an in vitro phenotypic screening approach for the identification of immunomodulatory agents and thus addresses a critical gap in the field of immuno-oncology. Our pilot screen identified statins, a drug family gaining increasing interest as repurposing candidates for cancer treatment, as enhancers of immune cell-induced cancer cell death. We speculate that the clinical benefits described for cancer patients receiving statins are not simply caused by a direct effect on the cancer cells but rather are dependent on the combined effect exerted on both cancer and immune cells.
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| 12. |
- Selvin, Tove, et al.
(författare)
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The Immuno-Oncology Hollow Fiber Assay
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In order to facilitate the translation of novel immunotherapies from bench to bedside, continued development of predictive preclinical models is essential. Herein, we developed the immuno-oncology hollow fiber assay (HFA) to bridge the gap between cell based in vitro assays and more complex mouse models for evaluation of immuno-oncological agents. The colorectal cancer (CRC) cell line HCT116-GFP and human peripheral blood mononuclear cells (PBMCs) were co-cultured inside semipermeable hollow fibers. As a proof of concept, aCD3 and IL-2 was used to induce immune cell-mediated cancer cell death. During in vitro characterization of the model system, an enhanced effect of aCD3 and IL-2 was observed in the HFA compared to conventional monolayers. Further investigation demonstrated that increased cell proximity alone is sufficient to augment immune cell activation and effector function. To assess the functionality of the assay in vivo, a pilot study was performed using nude mice. Hollow fibers were surgically implanted intraperitoneally (i.p.) and the mice received local injections of aCD3 at the time of implantation and/ or systemic IL-2 via i.p. injection once daily for 3 consecutive days. Compared to untreated mice and mice receiving IL-2 alone, the combination of aCD3 and IL-2 resulted in a significant decrease in cancer cell viability. Traditional in vivo models often necessitate lengthy observation periods to monitor tumor growth and treatment response. We have developed a simplified model system that enables initial in vivo evaluation of immunological agents on cancer and immune cells of human origin within a matter of days.
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| 13. |
- Ståhle, Alexander, et al.
(författare)
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Designguide för Smarta gator
- 2022
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Designguiden för smarta gator konkretiserar hur de fyra megatrenderna urbanisering, digitalisering, samhällsförändringar och miljöförändringar leder till nya krav och utformningsprinciper för framtidens gator. Guiden är tänkt att fungera som en inspiration och ett underlag för att förnya svensk gatupolicy på nationell, regional och kommunal nivå.Guiden innehåller utöver en inledning följande kapitel: en historisk tillbakablick (gatans utveckling), gatans användning, gatans delar, gatans design, designprocessen, guidens genomförande.
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| 14. |
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| 15. |
- Ahl, Helene, 1958-, et al.
(författare)
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Can governments support both women and entrepreneurship?
- 2014
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Ingår i: Diana International Research Conference 2014.
-
Konferensbidrag (refereegranskat)abstract
- Feminism in Sweden as well as in the other Scandinavian countries was largely formulated as state feminism. The women’s movement has cooperated with feminists in the state, resulting in societies that count as the most gender equal in the world. The Scandinavian countries are consistently ranked in the top position on international gender equality indices. The state has provided a large publicly financed welfare sector that both employs many women, and makes it possible to combine work and family through family friendly policies. The last decade has seen a political change influenced by neoliberal thought, in which politicians hand over welfare state responsibilities to the market, and instead encourage entrepreneurship, not least among women. The Swedish government has since 20 years back programs and policies to promote women’s entrepreneurship. The Swedish state has during the same period shrunk the public sector and privatized many operations in services and care, which traditionally employ many women. Instead, women are encouraged to start businesses in former public sectors. Empirical studies suggest however, that all of the increase of women’s entrepreneurship in these sectors is within low-paid, micro service businesses, typically child minding.Traditional state feminism has also changed character. Instead of public regulations, market solutions are advocated. In this paper we ask how to theorize this change from a feminist theory perspective; we ask what the implications for feminist action are, and we ask what consequences for women’s position in society are. We use research literature and policy texts as our empirical material and conduct a critical literature analysis. We conclude that the entrepreneurship discourse challenges, and possibly weakens state feminism and feminist action as we have known it in the Scandinavian countries, but may also offer new forms of feminist resistance, on market terms.
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| 16. |
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| 17. |
- Ahl, Helene, 1958-, et al.
(författare)
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Entrepreneurship for equality?
- 2013
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Ingår i: The International Helix conference 2013, Linköping, Sweden, June.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 18. |
- Ahl, Helene, 1958-, et al.
(författare)
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Entrepreneurship in rural areas : The role of women?
- 2017
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Ingår i: Paper presented at: 31st RENT Conference, Lund, 16-17 NOV 2017. - : European Institute for Advanced Studies in Management. ; , s. 1-20
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Konferensbidrag (refereegranskat)
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| 19. |
- Ahl, Helene, 1958-, et al.
(författare)
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From feminism to FemInc.ism : On the uneasy relationship between feminism, entrepreneurship and the Nordic welfare state
- 2016
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Ingår i: The International Entrepreneurship and Management Journal. - : Springer Science and Business Media LLC. - 1554-7191 .- 1555-1938. ; 12:2, s. 369-392
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Tidskriftsartikel (refereegranskat)abstract
- Feminism in the Nordic countries was primarily formulated in terms of ‘state feminism’. The women’s movement cooperated with feminist government officials and politicians, resulting in societies that can be considered to be the most gender-equal societies in the world. Historically, the state provided for a large publicly-financed welfare sector which made it possible for many women to combine work and family through the state’s implementation of family-friendly policies, while simultaneously providing employment opportunities for many women. However, since the financial crisis of the 1990s, there has been a political change influenced by neo-liberal thought, in which politicians have handed over the welfare state’s responsibilities to the market, and, instead, the politicians have encouraged entrepreneurship, not least among women. Further to this development, there has been a change in emphasis from entrepreneurship (understood as starting and running a business) to entrepreneurialism which, in addition to a belief in the efficacy of market forces, also contains a social dimension where individuals are supposed to be flexible and exercise choice. In this article, we ask whether this entails a change in the feminist project in the Nordic countries, and if so, what the likely consequences are for this project, both in practice and in research. In order to answer this question, we reviewed existing Nordic research on women’s entrepreneurship and examined how this body of work conceptualizes entrepreneurship, gender, the state, and equality. We also considered whether any trends could be identified. We relate our findings to recent changes in government policy and conclude that the current discourse on entrepreneurship challenges, and possibly weakens, state feminism, but we also conclude that this discourse may also provide space for new forms of feminist action, in market terms. We coin the term FemInc.ism to denote feminist action through enterprise and we discuss a number of important challenges that research on this phenomenon is faced with.
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| 20. |
- Ahl, Helene, 1958-, et al.
(författare)
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Is institutional support for women’s entrepreneurship feminist?
- 2014
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Ingår i: Gender, Work & Organization. - : John Wiley & Sons. ; , s. 142-142
-
Konferensbidrag (refereegranskat)abstract
- Feminism in Sweden as well as in the other Scandinavian countries was largely formulated as state feminism. The women's movement has cooperated with feminists in the state, resulting in societies that count as the most gender equal in the world. The Scandinavian countries are consistently ranked in the top position on international gender equality indices. The state has provided a large publicly financed welfare sector that both employs many women, and makes it possible to combine work and family through family friendly policies. The last decade has seen a politica l change influenced by neoliberal thought, in which politicians hand over welfare state responsibilities to the market, and instead encourage entrepreneurship, not least among women. The Swedish government has since 20 years back programs and policies to promote women's entrepreneurship. The Swedish state has during the same period shrunk the pub lic sector and privatized many operations in services and care, which traditionally employ many women. Instead, women are encouraged to start businesses in former public sectors. Empirica l studies suggest however, that all of the increase of women 's entrepreneurs hip in these sectors is within low-paid, micro service businesses, typically child minding.Traditional state feminism has also changed character. Instead of public regulations, market solutions are advocated. In this paper we ask how to theorize this change from a feminist theory perspective; we ask what the implications for feminist action are, and we ask what consequences for women's position in society are. We use research literature and policy texts as our empirical material and conduct a critical literature analysis. We conclude that the entrepreneurship discourse challenges, and possibly weakens state feminism and feminist action as we have known it in the Scandinavian countries, but may also offer new forms of feminist resistance, on market terms.
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| 21. |
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| 22. |
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| 23. |
- Ahl, Helene, et al.
(författare)
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Will business ownership support gender equality?
- 2012
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Konferensbidrag (refereegranskat)abstract
- Current Swedish as well as international policy advocates an increase inwomen’s business ownership. The reasons center around economic growth:women start businesses at a lower rate than men, and are therefore seen asan untapped resource in stagnant economies. Busienss ownership is advo-cated as a viable alternative to unemployment. Women’s business owner-ship is further seen as instrumental in the neo-liberal transformation of thepublic sector, with privatization of former public commitments in educa-tion and care. In developing countries the arguments center around pov-erty alleviation – help to self-help is advocated. Feminist arguments suchas equal distribution of power and influence among men and women arelargely absent, and a discussion of the allocation of unpaid, domestic workbetween men and women is also absent. The discussion on entrepreneur-ship and the discussion on feminism seem to live side by side, with littleexchange between them. Neither feminist theory, nor extant entrepreneur-ship theory adequately account for feminist agency and activism within aglobalized market economy, in which discourses of entrepreneurship, in-novation and economic growth take precedence. Doing so would implychallenges of and developments of concepts like enterprise, gender, growth,competition, agency, feminist activism and gender equality. In this paperwe seek to bridge and combine feminist and entrepreneurship theories innew ways. We suggest a feminist theoretical understanding of current dis-courses, practices and policies regarding entrepreneurship and women’sentrepreneurship.
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| 24. |
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| 25. |
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| 26. |
- Ahl, Helene, 1958-, et al.
(författare)
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Women's contributions to rural development : implications for entrepreneurship policy
- 2023
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Ingår i: International Journal of Entrepreneurial Behaviour & Research. - : Emerald Group Publishing Limited. - 1355-2554 .- 1758-6534.
-
Tidskriftsartikel (refereegranskat)abstract
- PurposePolicy for women's entrepreneurship is designed to promote economic growth, not least in depleted rural areas, but very little is known about the contributions of rural women entrepreneurs, their needs or how the existing policy is received by them. Using a theoretical framework developed by Korsgaard et al. (2015), the authors analyse how rural women entrepreneurs contribute to rural development and discuss the implications for entrepreneurship policy. This paper aims to focus on the aforementioned objectives.Design/methodology/approachThe authors interviewed 32 women entrepreneurs in rural Sweden representing the variety of businesses in which rural Swedish women are engaged. The authors analysed their contributions to rural development by analysing their motives, strategies and outcomes using Korsgaard et al.'s framework of "entrepreneurship in the rural" and "rural entrepreneurship" as a heuristic, interpretative device.FindingsIrrespective of industry, the respondents were deeply embedded in family and local social structures. Their contributions were substantial, multidimensional and indispensable for rural viability, but the policy tended to bypass most women-owned businesses. Support in terms of business training, counselling and financing are important, but programmes especially for women tend to miss the mark, and so does rural development policy. More important for rural women entrepreneurs in Sweden is the provision of good public services, including for example, schools and social care, that make rural life possible.Research limitations/implicationsTheoretically, the findings question the individualist and a-contextual focus of much entrepreneurship research, as well as the taken-for-granted work-family divide. How gender and how the public and the private are configured varies greatly between contexts and needs contextual assessment. Moreover, the results call for theorising place as an entrepreneurial actor.Practical implicationsBased on the findings, the authors advise future policymakers to gender mainstream entrepreneurship policy and to integrate entrepreneurship and rural development policy with family and welfare state policy.Originality/valueThe paper highlights how rural women respond to policy, and the results are contextualised, making it possible to compare them to other contexts. The authors widen the discussion on contributions beyond economic growth, and the authors show that policy for public and commercial services and infrastructure is indeed also policy for entrepreneurship.
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| 27. |
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| 28. |
- Ahlén Bergman, Emma, et al.
(författare)
-
Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients
- 2018
-
Ingår i: Clinical Epigenetics. - : BMC. - 1868-7083 .- 1868-7075. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Urinary bladder cancer is a common malignancy worldwide. Environmental factors and chronic inflammation are correlated with the disease risk. Diagnosis is performed by transurethral resection of the bladder, and patients with muscle invasive disease preferably proceed to radical cystectomy, with or without neoadjuvant chemotherapy. The anti-tumour immune responses, known to be initiated in the tumour and draining lymph nodes, may play a major role in future treatment strategies. Thus, increasing the knowledge of tumour-associated immunological processes is important. Activated CD4+ T cells differentiate into four main separate lineages: Th1, Th2, Th17 and Treg, and they are recognized by their effector molecules IFN-γ, IL-13, IL-17A, and the transcription factor Foxp3, respectively. We have previously demonstrated signature CpG sites predictive for lineage commitment of these four major CD4+ T cell lineages. Here, we investigate the lineage commitment specifically in tumour, lymph nodes and blood and relate them to the disease stage and response to neoadjuvant chemotherapy.RESULTS: Blood, tumour and regional lymph nodes were obtained from patients at time of transurethral resection of the bladder and at radical cystectomy. Tumour-infiltrating CD4+ lymphocytes were significantly hypomethylated in all four investigated lineage loci compared to CD4+ lymphocytes in lymph nodes and blood (lymph nodes vs tumour-infiltrating lymphocytes: IFNG -4229 bp p < 0.0001, IL13 -11 bp p < 0.05, IL17A -122 bp p < 0.01 and FOXP3 -77 bp p > 0.05). Examination of individual lymph nodes displayed different methylation signatures, suggesting possible correlation with future survival. More advanced post-cystectomy tumour stages correlated significantly with increased methylation at the IFNG -4229 bp locus. Patients with complete response to neoadjuvant chemotherapy displayed significant hypomethylation in CD4+ T cells for all four investigated loci, most prominently in IFNG p < 0.0001. Neoadjuvant chemotherapy seemed to result in a relocation of Th1-committed CD4+ T cells from blood, presumably to the tumour, indicated by shifts in the methylation patterns, whereas no such shifts were seen for lineages corresponding to IL13, IL17A and FOXP3.CONCLUSION: Increased lineage commitment in CD4+ T cells, as determined by demethylation in predictive CpG sites, is associated with lower post-cystectomy tumour stage, complete response to neoadjuvant chemotherapy and overall better outcome, suggesting epigenetic profiling of CD4+ T cell lineages as a useful readout for clinical staging.
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| 29. |
- Andrade, Jorge, et al.
(författare)
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Applications of grid computing in genetics and proteomics
- 2007
-
Ingår i: Applied Parallel Computing. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783540757542 ; , s. 791-798
-
Konferensbidrag (refereegranskat)abstract
- The potential for Grid technologies in applied bioinformatics is largely unexplored. We have developed a model for solving computationally demanding bioinformatics tasks in distributed Grid environments, designed to ease the usability for scientists unfamiliar with Grid computing. With a script-based implementation that uses a strategy of temporary installations of databases and existing executables on remote nodes at submission, we propose a generic solution that do not rely on predefined Grid runtime environments and that can easily be adapted to other bioinformatics tasks suitable for parallelization. This implementation has been successfully applied to whole proteome sequence similarity analyses and to genome-wide genotype simulations, where computation time was reduced from years to weeks. We conclude that computational Grid technology is a useful resource for solving high compute tasks in genetics and proteomics using existing algorithms.
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| 30. |
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| 31. |
- Bergenstråhle, Malin, 1977-
(författare)
-
Crystalline cellulose in bulk and at interfaces as studied by atomistic computer simulations
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cellulose is a linear polysaccharide, serving as reinforcement in plant cell walls.Understanding its structure and properties is of importance in the developmentof nanostructured cellulose materials. The aim of this thesis is to address thisquestion by applying the computer simulation technique Molecular Dynamics(MD) onto an atomistic model of a native crystal form of cellulose.A molecular model of crystalline cellulose Iβ was developed and simulatedwith the GROMACS simulation software package.Temperature dependence of the crystal bulk model was investigated. A gradualtransition was observed between 350 K and 500 K in concordance with experimentalresults. The high temperature structure differed from the originalstructure in terms of crystal cell parameters, hydrogen bonding network andelastic modulus.Spin-lattice relaxation times, T1, from solid-state Nuclear Magnetic Resonancespectroscopy were compared with values calculated from the dynamics ofthe C4-H4 vector in MD simulations. Calculated T1 compared well with experimentallyobtained, suggesting well reproduced dynamics. Moreover, a differencein T1 of about a factor 2 was found for C4 atoms at surfaces parallel to differentcrystallographic planes. This supports a proposed explanation regarding anobserved doublet for C4 atoms in the NMR spectrum.Interaction energies between crystalline cellulose and water and 6− hydroxyhexanal(CL) were determined from simulations. Water was found to interactstronger with cellulose than CL. Moreover, the effect of grafting CL onto surfacecellulose chains was examined. For both water and CL interfaces, grafting ledto increased interaction. Electrostatic interactions were dominating in all cases,however grafting increased the importance of van der Waals interactions.The experimental approach to investigate polymer desorption by pulling itfrom a surface by the use of Atomic Force Microscopy (AFM) was enlightenedwith a modelling study. A single cellulose octamer was pulled from a cellulosecrystal into water and cyclohexane. Resulting pull-off energies proved a clearsolvent effect, 300 − 400 [kJ/mole] in cyclohexane and 100 − 200 [kJ/mole] inwater.In general, MD was shown to be useful when applied in combination withfeasible experimental techniques such as NMR and AFM to increase the fundamentalunderstanding of cellulose structure and properties.
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| 32. |
- Bergenstråhle, Malin, 1977-, et al.
(författare)
-
Dynamics of Cellulose-Water Interfaces : NMR Spin-Lattice Relaxation Times Calculated from Atomistic Computer Simulations
- 2008
-
Ingår i: Journal of Physical Chemistry B. - Washington : ACS Publications. - 1520-6106 .- 1520-5207. ; 112:9, s. 2590-2595
-
Tidskriftsartikel (refereegranskat)abstract
- Solid-state nuclear magnetic resonance (CP/MAS 13C NMR) spectroscopy has often been used to study cellulose structure, but some features of the cellulose NMR spectrum are not yet fully understood. One such feature is a doublet around 84 ppm, a signal that has been proposed to originate from C4 atoms at cellulose fibril surfaces. The two peaks yield different T1, differing by approximately a factor of 2 at 75 MHz. In this study, we calculate T1 from C4-H4 vector dynamics obtained from molecular dynamics computer simulations of cellulose Iβ-water interfacial systems. Calculated and experimentally obtained T1 values for C4 atoms in surface chains fell within the same order of magnitude, 3-20 s. This means that the applied force field reproduces relevant surface dynamics for the cellulose-water interface sufficiently well. Furthermore, a difference in T1 of about a factor of 2 in the range of Larmor frequencies 25-150 MHz was found for C4 atoms in chains located on top of two different crystallographic planes, namely, (110) and (10). A previously proposed explanation that the C4 peak doublet could derive from surfaces parallel to different crystallographic planes is herewith strengthened by computationally obtained evidence. Another suggested basis for this difference is that the doublet originates from C4 atoms located in surface anhydro-glucose units with hydroxymethyl groups pointing either inward or outward. This was also tested within this study but was found to yield no difference in calculated T1.
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| 33. |
- Bergenstråhle, Malin, 1977-, et al.
(författare)
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Force Pulling of Single Cellulose Chains at the Crystalline Cellulose-Liquid Interface : A Molecular Dynamics Study
- 2009
-
Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 25:8, s. 4635-4642
-
Tidskriftsartikel (refereegranskat)abstract
- Pulling single cellulose molecules from a crystalline cellulose surface has been modeled by molecular dynamics (MD) simulations of the experimental procedure used in atomic force microscopy (AFM). Specifically, the aim of the study was to investigate cellulose interactions at desorption. Simulations were performed in both water and the organic solvent cyclohexane. Moreover, the effects of initial octamer conformation and orientation with respect to the surface chains were studied. A strong effect from the solvent was observed. In cyclohexane, normal forces of 200-500 pN and energies of 43.5 +/- 6.0 kJ/mol glucose unit were required to pull off the octamer. The normal forces in water were substantially lower, around 58 pN, and the energies were 18.2 +/- 3.6 kJ/mol glucose unit. In addition, the lateral components of the pull-off force were shown to provide information on initial conformation and orientation. Hydrogen bonds between the octamer and surface were analyzed and found to be an important factor in the pull-off behavior. Altogether, it was shown that MD provides detailed information on the desorption processes that may be useful for the interpretation of AFM experiments.
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| 34. |
- Bergenstråhle, Malin, 1977-, et al.
(författare)
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Molecular modeling of interfaces between cellulose crystals and surrounding molecules : Effects of caprolactone surface grafting
- 2008
-
Ingår i: European Polymer Journal. - Amsterdam : Elsevier. - 0014-3057 .- 1873-1945. ; 44:11, s. 3662-3669
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Tidskriftsartikel (refereegranskat)abstract
- A technical problem in cellulosic nanocomposite materials is the weak interaction between hydrophilic cellulose and hydrophobic polymer matrices. One approach to solve this difficulty is to chemically graft monomers of the matrix polymer onto the cellulose surface. An important question is to understand the effect such surface modification has on the interfacial properties. Semi-empirical approaches to estimate work of adhesion based on surface energies do not provide information on specific molecular interactions. Details about these interactions were obtained using molecular dynamics (MD) simulation. Cellulose interfaces with water and caprolactone medium were modeled with different amounts of grafted caprolactone. The modification lead to an increased work of adhesion between the surface and its surrounding medium. Furthermore, the MD simulations showed that the interaction between cellulose, both modified and non-modified, and surrounding medium is dominated by Coulomb interactions, predominantly as hydrogen bonds.
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| 35. |
- Bergenstråhle, Malin, 1977-, et al.
(författare)
-
Thermal Response in Crystalline Iβ Cellulose : A Molecular Dynamics Study
- 2007
-
Ingår i: Journal of Physical Chemistry B. - Washington : ACS Publications. - 1520-6106 .- 1520-5207. ; 111:30, s. 9138-9145
-
Tidskriftsartikel (refereegranskat)abstract
- The influence of temperature on structure and properties of the cellulose Iβ crystal was studied by molecular dynamics simulations with the GROMOS 45a4 force-field. At 300 K, the modeled crystal agreed reasonably with several sets of experimental data, including crystal density, corresponding packing and crystal unit cell dimensions, chain conformation parameters, hydrogen bonds, Young's modulus, and thermal expansion coefficient at room temperature. At high-temperature (500 K), the cellulose chains remained in sheets, despite differences in the fine details compared to the room-temperature structure. The density decreased while the a and b cell parameters expanded by 7.4% and 6%, respectively, and the c parameter (chain axis) slightly contracted by 0.5%. Cell angles α and β divided into two populations. The hydroxymethyl groups mainly adopted the gt orientation, and the hydrogen-bonding pattern thereby changed. One intrachain hydrogen bond, O2'H2'···O6, disappeared and consequently the Young's modulus decreased by 25%. A transition pathway between the low- and high-temperature structures has been proposed, with an initial step being an increased intersheet separation, which allowed every second cellulose chain to rotate around its helix axis by about 30°. Second, all hydroxymethyl groups changed their orientations, from tg to gg (rotated chains) and from tg to gt (non-rotated chains). When temperature was further increased, the rotated chains returned to their original orientation and their hydroxymethyl groups again changed their conformation, from gg to gt. A transition temperature of about 450 K was suggested; however, the transition seems to be more gradual than sudden. The simulated data on temperature-induced changes in crystal unit cell dimensions and the hydrogen-bonding pattern also compared well with experimental results.
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| 36. |
- Bergenstråhle-Wohlert, Malin, et al.
(författare)
-
Concentration enrichment of urea at cellulose surfaces : results from molecular dynamics simulations and NMR spectroscopy
- 2012
-
Ingår i: Cellulose. - : Springer Science and Business Media LLC. - 0969-0239 .- 1572-882X. ; 19:1, s. 1-12
-
Tidskriftsartikel (refereegranskat)abstract
- A combined solid-state NMR and Molecular Dynamics simulation study of cellulose in urea aqueous solution and in pure water was conducted. It was found that the local concentration of urea is significantly enhanced at the cellulose/solution interface. There, urea molecules interact directly with the cellulose through both hydrogen bonds and favorable dispersion interactions, which seem to be the driving force behind the aggregation. The CP/MAS (13)C spectra was affected by the presence of urea at high concentrations, most notably the signal at 83.4 ppm, which has previously been assigned to C4 atoms in cellulose chains located at surfaces parallel to the (110) crystallographic plane of the cellulose I beta crystal. Also dynamic properties of the cellulose surfaces, probed by spin-lattice relaxation time (13)CT (1) measurements of C4 atoms, are affected by the addition of urea. Molecular Dynamics simulations reproduce the trends of the T (1) measurements and lends new support to the assignment of signals from individual surfaces. That urea in solution is interacting directly with cellulose may have implications on our understanding of the mechanisms behind cellulose dissolution in alkali/urea aqueous solutions.
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| 37. |
- Bergkvist, Charlotte, et al.
(författare)
-
Exposure to dioxin-like pollutants via different food commodities in Swedish children and young adults.
- 2008
-
Ingår i: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915 .- 1873-6351. ; 46:11, s. 3360-3367
-
Tidskriftsartikel (refereegranskat)abstract
- The dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) in terms of toxic equivalents (TEQs) was investigated in Swedish children and young adults. Exposure was estimated from concentration data of six groups of individual food commodities (meat, fish, dairy products, egg, edible fats and other foodstuff) combined with food intake data from a 7-day record book obtained from 670 individuals aged 1-24 years. The results showed that Swedish boys and girls, up to the age of ten, had a median TEQ intake that exceeded the tolerable daily intake (TDI) of 2 pg TEQ/kg body weight. Children exceeding the TDI varied from almost all individuals among the youngest children to about 20% among young men and women. Dairy and fish products were the main sources of exposure for the average child, accounting for 59% of the total TEQ intake. The individuals most highly exposed were, on the other hand, characterized by a high consumption of fish. Since children constitute a vulnerable group, results obtained from the present study show that it is essential to perform age specific dietary intake assessments of pollutants and more carefully consider sensitive and/or highly exposed groups in the population in the risk management processes.
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| 38. |
- Berglund, Jennie, et al.
(författare)
-
A molecular dynamics study of the effect of glycosidic linkage type in the hemicellulose backbone on the molecular chain flexibility
- 2016
-
Ingår i: The Plant Journal. - : John Wiley & Sons Ltd.. - 0960-7412 .- 1365-313X. ; 88:1, s. 56-70
-
Tidskriftsartikel (refereegranskat)abstract
- The macromolecular conformation of the constituent polysaccharides in lignocellulosic biomass influences their supramolecular interactions, and therefore their function in plants and their performance in technical products. The flexibility of glycosidic linkages from the backbone of hemicelluloses was studied by evaluating the conformational freedom of the φ and ψ dihedral angles using molecular dynamic simulations, additionally selected molecules were correlated with experimental data by NMR spectroscopy. Three types of β-(1→4) glycosidic linkages involving the monosaccharides (Glcp, Xylp and Manp) present in the backbone of hemicelluloses were defined. Different di- and tetrasaccharides with combinations of such sugar monomers from hemicelluloses were simulated and free energy maps of the φ - ψ space and hydrogen bonding patterns were obtained. The glycosidic linkage between Glc-Glc or Glc-Man (C-type) was the stiffest with mainly one probable conformation; the linkage from Man-Man or Man-Glc (M-type) was similar but with an increased probability for an alternative conformation making it more flexible, and the linkage between two Xyl-units (X-type) was the most flexible with two almost equally populated conformations. Glycosidic linkages of the same type showed essentially the same conformational space in both disaccharides and in the central region of tetrasaccharides. Different probabilities of glycosidic linkage conformations in the backbone of hemicelluloses can be directly estimated from the free energy maps, which to a large degree affect the overall macromolecular conformations of these polymers. The information gained contributes to an increased understanding of hemicelluloses’ function both in the cell wall and in technical products.
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| 39. |
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| 40. |
- Berglund, Karin, et al.
(författare)
-
An alternative entrepreneurial university?
- 2021. - 1
-
Ingår i: A Research Agenda for the Entrepreneurial University. - Cheltenham : Edward Elgar Publishing. - 9781788975032 - 9781788975049 ; , s. 7-28
-
Bokkapitel (refereegranskat)abstract
- In this chapter, we discuss the entrepreneurial university as a part of the entrepreneurialisation of society. To investigate how this affects the University we take inspiration from Mazzucato´s discussion about the entrepreneurial state. Based on a rich empirical case where entrepreneurship has been introduced in a different way than described in extant literature (and policy), two conceptualisations of the entrepreneurial university are elaborated on. In “The Entrepreneurial University” (TEU) focus is set on how existing technology can be used in a new context or turned into innovations. In contrast, in the “Alternative Entrepreneurial University” (AEU) processes and practices are introduced to facilitate reflexivity with regards to the role of entrepreneurship in late capitalism. It is proposed that, rather than choosing one of these two ‘idea(l)s’, it may be beneficial to find ways to unite the two approaches, finding ways to create stability for knowledge production that can feed into both new technologies and novel ways of organizing society for the betterment of its constituents. Further it is suggested that the two conceptualisations can help to advance research approaches on the entrepreneurialisation of universities in order to learn how this sets and shifts boundaries for democracy and our understanding of knowledge production.
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| 41. |
- Berglund, Karin, 1967-, et al.
(författare)
-
Conceptualising feminist resistance in the postfeminist terrain
- 2023
-
Ingår i: Gender in Management. - : Emerald Group Publishing Limited. - 1754-2413 .- 1754-2421. ; 38:2, s. 183-199
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: In this paper, women entrepreneurs are seen as leaders and women leaders as entrepreneurial, making both groups an easy target of postfeminist expectations, governed by calls to embody the entrepreneurial self. Acknowledging that the entrepreneurial self has its roots in the universal, rational and autonomous subject, which was shaped in a male form during the Enlightenment, the purpose of this study is to conceptualise feminist resistance as a process through which the autonomous subject can be de-stabilised. Design/methodology/approach: Empirically, this study draws on an extensive research project on women's rural entrepreneurship that includes 32 in-depth interviews with women entrepreneurs in rural Sweden. This study interpreted expressions of resistance from the women by using an analytical framework the authors developed based on Jonna Bornemark's philosophical treatise. Findings: Feminist resistance unfolds as an interactive and iterative learning process where the subject recognises their voice, strengthens their voice and beliefs in a relational process and finally sees themselves as a fully fledged actor who finds ways to overcome obstacles that get in their way. Conceptualising resistance as a learning process stands in sharp contrast to the idea of resistance as enacted by the autonomous self. Research limitations/implications: This study helps researchers to understand that what they may have seen as a sign of weakness among women, is instead a sign of strength: it is a first step in learning resistance that may help women create a life different from that prescribed by the postfeminist discourse. In this way, researchers can avoid reproducing women as "weak and inadequate". Originality/value: Through the re-writing of feminist resistance, the masculine entrepreneurship discourse including the notion of the autonomous self is challenged, and a counternarrative to the postfeminist entrepreneurial woman is developed. Theorising resistance as a learning practice enables a more transforming research agenda, making it possible to see women as resisting postfeminist expectations of endless competition with themselves and others.
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| 42. |
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| 43. |
- Berglund, Knut-Erland, et al.
(författare)
-
Social innovation i Svenska kyrkan
- 2016
-
Ingår i: Svensk kyrkotidning. - 0346-2153. ; 112:1, s. 13-
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Idag ser vi hur kyrkan ställer om sina verksamheter för att hantera aktuella samhällsutmaningar såsom flyktingströmmar, fattigdom, hemlöshet och andra former av social exkludering. Det finns en mängd exempel på hur kyrkan utvecklar innovativa arbetssätt för att möta olika sociala behov i den vardagliga verksamheten. Begreppet social innovation kan bidra till att synliggöra och förstärka kyrkans innovativa utveckling av sociala arbetssätt och metoder inom och mellan organisations- och sektorsgränser. Det kan därigenom bidra till att förtydliga kyrkans förändrade roll i samhället, exempelvis vad gäller dess bidrag till lokal och regional utveckling. Vi vill här beskriva den satsning som forskningsenheten inlett på att kartlägga och analysera social innovation i Svenska kyrkans nutida och historiska verksamheter.
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| 44. |
- Berglund, Knut-Erland, et al.
(författare)
-
Social innovation now and then in the Church of Sweden
- 2016
-
Ingår i: Diaconia. Journal for the Study of Christian Social Practice. - : Vandenhoeck & Ruprecht GmbH & Co, KG. - 1869-3261 .- 2196-9027. ; 7:2, s. 125-141
-
Tidskriftsartikel (refereegranskat)abstract
- Social innovation – referring to the development and implementation of new social practicesto improve the quality of life, well-being, relations and empowerment of individualsand communities – shares similarities with the diaconal work performed as part of Christiansocial practices and the welfare services provided by Christian communities and parishes.Based on the results from a study of innovative social practices in the Church of Sweden,this article scrutinizes the character of a selection of historical and contemporary examplesof social innovation in the Church, in order to further develop the knowledge of how to developnew forms of diaconal work related to welfare services as the societal context changes.By pinpointing the content, process, empowerment, innovation and normativity of socialinnovation, the analysis highlights pivotal components in the transition from social exclusionto social inclusion in the Church’s specific settings.
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| 45. |
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| 46. |
- Berglund, Karin, et al.
(författare)
-
Genusperspektiv på entreprenörskap : från kvinnors företagande till feministisk aktivism
- 2023
-
Ingår i: Organisation & Samhälle. - : Föreningen Företagsekonomi i Sverige. - 2001-9114 .- 2002-0287. ; Mars 23
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Från inledningen: Den internationella forskningen om kvinnors företagande tog fart i början av 1990-talet. Redan 1989 publicerade pionjärerna Elisabeth Sundin och Carin Holmquist den svenska studien Kvinnor som företagare: Osynlighet, mångfald, anpassning. Studien banade väg för en livaktig svensk forskning inom ämnet. I början handlade forskningen om att visa att kvinnor som företagare faktiskt finns. Trots att kvinnor sedan många år utgjort ungefär en tredjedel av alla företagare så ansågs och anses fortfarande företagare vara män. I ett senare skede fokuserade forskningen på villkoren för företag drivna av kvinnor. Många studier visade till exempel att kvinnor har svårare att få finansiering för sina verksamheter än män. Det kan bero på direkt diskriminering, men också på att kvinnor är verksamma i feminint kodade branscher som exempelvis detaljhandel eller personlig service. I dessa branscher har man sällan stora tillgångar som kan ställas som säkerhet för ett lån. Branscherna är också arbetskraftsintensiva, vilket gör det svårare att uppnå skalfördelar och hög lönsamhet.
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| 47. |
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| 48. |
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| 49. |
- Berglund, Karin, 1967-, et al.
(författare)
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To play or not to play: that is the question : entrepreneuring as gendered play
- 2015
-
Ingår i: Scandinavian Journal of Management. - : Elsevier BV. - 0956-5221 .- 1873-3387. ; 31:2, s. 206-218
-
Tidskriftsartikel (refereegranskat)abstract
- How can play be used to unravel the discourse of the gendered hero entrepreneur and instead describe mundane entrepreneuring? Further, how can the doing of gendered social orders be problematized when entrepreneuring is equated with play? In this article we answer these questions by engaging with the French social theorist Caillois’ (1961) conceptualization of play as being at the heart of all higher culture. Two ethnographic cases act as our vehicle in analysing play as entrepreneuring. From a rich description of these cases we find that it is not a question of playing or not playing, but about how to play. All four forms of play described by Caillois are present, which illustrates the variation of entrepreneuring and the richness of activities conducted in the ‘doing of entrepreneurship’. Further, both ways of playing discussed by Caillois are found. Whilst these two ways are interrelated on a continuum in the theory of play, they have been separated in entrepreneurship discourse, where they underpin the tendency to differentiate between the hero entrepreneur and ordinary people. Finally, we engage in a more interpretive and reflective discussion on entrepreneuring as performative acts through which social orders can be not only reproduced but also transformed.
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| 50. |
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