| 1. |
- Andersson-Sköld, Yvonne, et al.
(författare)
-
Effekter av samhällets säkerhetsåtgärder (ESS) : en kartering av arbetet idag med fokus på översvämningar, ras och skred
- 2012
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I denna rapport redovisas det arbete som pågått inom ESS-programmets första fas inom temaområde naturolyckor. Detta temaområde innefattar skred, ras, erosion och översvämningar. Målet med det arbete som presenteras i denna rapport har varit att skapa en överblick över hurman idag arbetar med dessa frågor i Sverige med fokus på kommunal nivå. Arbetet utgörs aven sammanställning av tidigare studier, beskrivning av metoder samt intervjuer med svenska och norska kommuner och myndigheter. I de svenska kommunerna har politiker och tjänstemän intervjuats.Förebyggande åtgärder för att minska sannolikheten för, eller konsekvensen av, olyckor vidtas ofta. Åtgärderna är baserade på en analys eller akut reaktion på en specifik händelse. Vissa åtgärder är platsspecifika och kan vara både fysiska och icke fysiska. Andra åtgärder är mer generella såsom lagstiftning och utbildningsinsatser, regional, nationell och internationell policy, direktiv och ramverk.
|
|
| 2. |
|
|
| 3. |
- Andersson-Sköld, Yvonne, et al.
(författare)
-
Landslide risk management : A brief overview and example from Sweden of current situation and climate change
- 2013
-
Ingår i: International Journal of Disaster Risk Reduction. - : Elsevier. - 2212-4209. ; 3:March, s. 44-61
-
Tidskriftsartikel (refereegranskat)abstract
- Landslide risk is a function of the probability of the event and its consequences. Previous research has shown that preventive measures to reduce the risk are preferred over reactive measures but, especially in developing countries, rarely undertaken. A contributing factor is the lack of evidence that preventive measures pay. This study includes a brief overview of landslide risk management in general and an investigation of the present risk management situation in Sweden based on interviews in 11 municipalities complemented with interviews in Norway. The result shows that climate change has become part of the general awareness and started to be taken into account in the municipal spatial planning. Landslide susceptibility maps and databases are useful tools in the complex spatial planning. The results indicate that the application of landslide susceptibility and risk maps as previously applied for preventive measures and spatial planning in the landslide prone area Gota alv river valley have been cost effective. Improved documentation and more active communication among different stakeholders would, however, contribute to more effective landslide management.
|
|
| 4. |
- Andersson-Sköld, Yvonne, et al.
(författare)
-
Sustainable decisions on the agenda – a decision support tool development and its application to climate change adaptation
- 2016
-
Ingår i: Local Environment : the International Journal of Justice and Sustainability. - : Informa UK Limited. - 1354-9839 .- 1469-6711. ; 21:1, s. 85-104
-
Tidskriftsartikel (refereegranskat)abstract
- A decision support tool aiming to facilitate discussion and transparency in land-use planning processes has been developed. It includes process steps initiating with an analysis of the current situation, identification of relevant actions and sustainability analysis steps. The sustainability was subdivided into human health and environment, resources, and social and economic impacts. The main difference between this risk analysis tool and others is the allowance of comparisons of present risks and consequences of measures early in the process. It also includes assessments from short- and long-term perspectives, such as taking into account climate change. It combines classic risk analysis with life-cycle assessment procedure. It has been developed and tested in co-operation with municipalities. The tests show that the tool is applicable and can be relevant in the planning process. It offers an iterative discussion framework that is systematic, condensed and yet a simplistic way of describing consequences. The criticism is that it is regarded as time demanding, but this can be managed by preparatory work
|
|
| 5. |
- Bergman, Ramona, et al.
(författare)
-
Effects of Security actions
- 2010
-
Ingår i: Geophysical Research Abstracts Vol. 12, EGU2010-7880.
-
Konferensbidrag (refereegranskat)abstract
- In a project funded by the Swedish Civil Contingencies Agency, the effort and work to reduce different kinds of accidents are being evaluated. The project wants to illuminate the links between actions and outcome, so we can learn from today’s performance and in the future select more effective measures and overall deal with accidents more efficiently. The project ESS covers the field of frequent accidents such as sliding accidents at home, in house fires and less common accidents such as chemical and land fill accidents up to even more rare accidents such as natural accidents and hazards. In the ESS project SGI (Swedish geotechnical institute) will evaluate the work and effort concerning various natural hazards limited to landslides, erosion and flooding. The aim is to investigate how municipalities handle, especially prevention, of such natural disasters today.The project includes several aspects such as:which are the driving forces for risk analysis in a municipalitydo one use risk mapping (and what type) in municipal risk analysiswhich aspects are most important when selecting preventive measuresin which way do one learn from past accidentsand from previous accidents elsewhere, by for example use existing databasesetcThere are many aspects that play a role in a well-functioning safety promotion work. The overall goal is to examine present work and activities, highlight what is well functioning and identify weak points. The aim is to find out where more resources are needed and give suggestions for a more efficient security work. This includes identification of the most efficient “tools” in use or needed. Such tools can be education, directives, funding, more easily available maps and information regarding previous accidents and preventive measures etc. The project will result in recommendations for more effective ways to deal with landslides, erosion and flooding. Since different kinds of problems can occur depending on level of authority the investigation of the security work will be done with authorities on both regional and local scale. At the moment the investigation process are in progress and preliminary results will be presented.
|
|
| 6. |
- Bergman, Ramona, et al.
(författare)
-
Efficiency of preventive actions for landslides and flooding : evaluation of Scandinavian practices
- 2011
-
Konferensbidrag (refereegranskat)abstract
- The results presented here covers natural hazards with focus on land slides and flooding. The results are based on Swedish/Scandinavian contexts. Natural events such as erosion, flooding and land slides are common, but the number of accidents (events causing severe negative impact) is rare. Therefore, in such analysis there is limited data and other information available which can be used for example in statistical analysis of actions and their effects. Instead, the analysis must be based on other information. The analysis may have to include aspects that only can be assessed by scenario and "what-if" analyses.In this project the main method has been interviews with officials in Swedish municipalities and national agencies in Sweden and Norway. In all municipalities, one politician and officials working with planning and rescue service have been interviewed. The study covers hazard and risk mapping, follow up of such maps, physical planning and lessons learned from previous events and activities.The final outcome of the research will be a review of what is found to be well functioning, identification of weak points and recommendations for the management of landslides, erosion and flooding. The present results indicate that hazard/risk maps are of great importance, but the knowledge about the maps and how to use them varies depending on who you ask and between municipalities. Most officials in municipalities are aware of climate change (CC) but, due to high uncertainties and since climate induced events such as natural hazards are rare, the issues are often not prioritized. Further, the results indicate that the documentation, communication and the responsibilities among different units is not always clear, having impacts on for example the knowledge transfer to new personnel.
|
|
| 7. |
- Bergman, Ramona, et al.
(författare)
-
Efficiency of preventive actions for landslides and flooding – evaluation of Scandinavian practices
- 2011
-
Konferensbidrag (refereegranskat)abstract
- Preventive actions can be, and are frequently, taken to reduce accidents and their consequences in different ways. The MSB funded research programme "Effects of Society's Security actions" (ESS, 2009-2013) aims to study the relationship between such actions and their effects. The program is divided into three subgroups: Frequent accidents Natural hazards (such as flooding, erosion and landslide) Chemical and landfill accidents The results presented here covers natural hazards with focus on land slides and flooding. The results are based on Swedish/Scandinavian contexts. Natural events such as erosion,flooding and land slides are common, but the number of accidents (events causing severe negative impact) is rare. Therefore, in such analysis there is limited data and other information available which can be used for example in statistical analysis of actions and their effects. Instead, the analysis must be based on other information. Therefore, the analysis may have to include aspects that only can be assessed by scenario and "what-if" analyses. In this project the main method has been interviews with officials in Swedish municipalities and national agencies in Sweden and Norway. The two levels are chosen since policies are taken on national (or international) level, while the key actionsand actors are on the municipal level. The interviews cover experiences and potential scenarios. In all municipalities, one politician and officials working with planning and rescue service have been interviewed. The study covers hazard and risk mapping, follow up of such maps, physical planning and lessons learned from previous events and activities. The final outcome of the research will be a review of what is found to be well functioning, identification of weak points and recommendations for the management of landslides, erosion and flooding. The present results indicate that hazard/risk maps are of great importance, but the knowledge about the maps and how to use them varies depending on who you ask and between municipalities. Most officials in municipalities are aware of climate change (CC) but, due to high uncertainties and since climate induced events such as natural hazards are rare, the issues are often not prioritized. Further, the results indicate that the documentation, communication and the responsibilities among different units is not always clear, having impacts on for example the knowledge transfer to new personnel. Also databases can be useful tools. The project has found that the use of such tools varies between Norway and Sweden. The aim is to identify the reasons for such deviation. The mostly mentioned suggestions of improvement in the prevention process are increased knowledge, user friendly guidance, clear organisational structure and responsibilities and nationally provided ear marked funding for preventive measures.
|
|
| 8. |
- Dima, Danai, et al.
(författare)
-
Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3-90 years.
- 2022
-
Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 452-469
-
Tidskriftsartikel (refereegranskat)abstract
- Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
|
|
| 9. |
- Frangou, Sophia, et al.
(författare)
-
Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
-
Tidskriftsartikel (refereegranskat)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
|
|
| 10. |
- Johansson, Magnus, 1970-, et al.
(författare)
-
How to measure efficiency in risk prevention?
- 2012
-
Konferensbidrag (refereegranskat)abstract
- Risk assessment methods form corner stones in the striving to reduce risks and threats to human life and society. Proposed actions can be physical or non-physical and adopted or declined after political evaluation, with consideration taken to available resources and estimated effect on risk. To optimize and avoid regrettable actions, decision-makers are in need of well-founded analyses of how efficient different options might be. Analytically, there are several possible steps that can contribute.Firstly, the correlation between a measure and its effect should be based on causality, which often is difficult to establish quantitatively. High frequent accidents (e.g. traffic) can normally be treated statistically , while low frequent accidents with severe consequences (e.g. natural hazards) are more restricted to qualitative descriptions of correlation. Systematic monitoring of injury and damage data and gathering into databases, are a crucial activity for causality valuation. Secondly, economic valuation of effect is an important contribution in a cost-benefit perspective. Thirdly, a measure often brings several different effects and some may fall outside the actual purpose. An additional problem is how to handle effects that exert varied influence on different stakeholders or social groups in society. Fourthly, certain criteria are required for final prioritization. For instance, in analysis of goal fulfillment, effects are compared with politically decided quantified goals.In cases where basic data from steps 1-3 are incomplete, alternative criteria like “acceptable risk” might be necessary to agree about politically. To use similar approaches on how to describe and quantify effect correlations, promote gathered efforts at local level where risk reducing measures are decided upon by different actors and with regard to diverse local conditions. Tests of suitable methods and approaches to measure efficiency of planned or accomplished actions in gain for risk prevention, are described and discussed.
|
|
| 11. |
- Kaufmann, Tobias, et al.
(författare)
-
Common brain disorders are associated with heritable patterns of apparent aging of the brain
- 2019
-
Ingår i: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
-
Tidskriftsartikel (refereegranskat)abstract
- Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
|
|
| 12. |
- Muvva, Jagadeeswara Rao, et al.
(författare)
-
Immunomodulatory Agents Combat Multidrug-Resistant Tuberculosis by Improving Antimicrobial Immunity
- 2021
-
Ingår i: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 224:2, s. 332-344
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Multidrug-resistant (MDR) tuberculosis has low treatment success rates, and new treatment strategies are needed. We explored whether treatment with active vitamin D-3 (vitD) and phenylbutyrate (PBA) could improve conventional chemotherapy by enhancing immune-mediated eradication of Mycobacterium tuberculosis. Methods. A clinically relevant model was used consisting of human macrophages infected with M. tuberculosis isolates (n = 15) with different antibiotic resistance profiles. The antimicrobial effect of vitD+PBA, was tested together with rifampicin or isoniazid. Methods included colony-forming units (intracellular bacterial growth), messenger RNA expression analyses (LL-37, beta-defensin, nitric oxide synthase, and dual oxidase 2), RNA interference (LL-37-silencing in primary macrophages), and Western blot analysis and confocal microscopy (LL-37 and LC3 protein expression). Results. VitD+PBA inhibited growth of clinical MDR tuberculosis strains in human macrophages and strengthened intracellular growth inhibition of rifampicin and isoniazid via induction of the antimicrobial peptide LL-37 and I,C3-dependent autophagy. Gene silencing of LL-37 expression enhanced MDR tuberculosis growth in vitD+PBA-treated macrophages. Me combination of vitD+PBA and isoniazid were as effective in reducing intracellular MDR tuberculosis growth as a >125-fold higher dose of isoniazid alone, suggesting potent additive effects of vitD+PBA with isoniazid. Conclusions. Immunomodulatory agents that trigger multiple immune pathways can strengthen standard MDR tuberculosis treatment and contribute to next-generation individualized treatment options for patients with difficult-to-treat pulmonary tuberculosis.
|
|
