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| 3. |
- Al-kharusi, Enass Said., et al.
(author)
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Large-Scale Retrieval of Coloured Dissolved Organic Matter in Northern Lakes Using Sentinel-2 Data
- 2020
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In: Remote Sensing. - : MDPI AG. - 2072-4292. ; 12:1, s. 157-157
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Journal article (peer-reviewed)abstract
- Owing to the significant societal value of inland water resources, there is a need for cost-effective monitoring of water quality on large scales. We tested the suitability of the recently launched Sentinel-2A to monitor a key water quality parameter, coloured dissolved organic matter (CDOM), in various types of lakes in northern Sweden. Values of a(420)CDOM (CDOM absorption at 420 nm wavelength) were obtained by analyzing water samples from 46 lakes in five districts across Sweden within an area of approximately 800 km2. We evaluated the relationships between a(420)CDOM and band ratios derived from Sentinel-2A Level-1C and Level-2A products. The band ratios B2/B3 (460 nm/560 nm) and B3/B5 (560 nm/705 nm) showed poor relationships with a(420)CDOM in Level-1C and 2A data both before and after the removal of outliers. However, there was a slightly stronger power relationship between the atmospherically-corrected B3/B4 ratio and a(420)CDOM (R2 = 0.28, n = 46), and this relationship was further improved (R2 = 0.65, n = 41) by removing observations affected by light haze and cirrus clouds. This study covered a wide range of lakes in different landscape settings and demonstrates the broad applicability of a(420)CDOM retrieval algorithms based on the B3/B4 ratio derived from Sentinel-2A. View Full-Text
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| 4. |
- Al-Mudhaffar, Azhar, et al.
(author)
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Ny ekvation för beräkning av uppställningsbehov i bussterminaler
- 2024
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In: Sammanställning av referat från Transportforum 2024. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 106-107
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Conference paper (other academic/artistic)abstract
- Behov för uppställningsplatser (UP) kan delas in i tre olika kategorier; reglering, paus och rast. Reglering avser buss som står parkerad med förare ombord för att vänta in nästa körtid. Tidsregleringen pågår normalt upp till 15 minuter. Paus och rast avser parkerad buss utan förare, i nära anslutning till paus-/rastlokal. En kortare paus är normalt ≥ 10 minuter och en planerad rast ≥30 minuter. Flera bussterminaler i Stockholmsregion har brist på påstigningshållplatser och uppställningsplatser, vilket är ett resultat av intresset för att minimera ytan eftersom bussterminaler vanligtvis upptar attraktiv mark nära stadskärnor. Metoder för beräkning av framtidsbehov är inte bristfria och behöver utvecklas för att säkerställa kapaciteten med optimal markanvändning. En befintlig metod som används av Trafikförvaltningen uppskattar att den erforderliga UP är lika med antalet busslinjer med turtäthet upp till 8 avgångar/tim. Linjer med högre turtäthet behöver mer än en plats. Denna metod är mer lämplig med linjer som har 6-8 avg./tim, men för lägre turtäthet resulterar den i behovsöverskattning. En ekvation i “Transit Capacity and Quality of Service Manual TCQSM, Report 165.” antar att UP (Nberths) för en linje beror på uppehållstiden (tlayover) och tidsavståndet mellan på följande bussar (theadway): Nberths = 1.2*(tlayover/theadway) Denna metod kräver data om tidsavstånd som är svårt att uppskatta vid framtids bussterminal i Stockholmsregion eftersom bussarna, efter uppehållstiden, inte alltid återvänder som samma linje. Därför finns det ett behov av att utveckla en användbar metod för att uppskatta antalet UP med tillgängliga data.Metoden har innefattat:LitteraturstudierFältobservationer av beläggning i uppställningsplatserWorkshops och intervjuer med trafikutövareFramtagande av ny linjär ekvation UP=a+(avg./tim)/bTillämpning och utvärderingJämförelse av resultat med andra metoderDiskussion och beslut om metoden i intern terminalgrupp.Den utvecklade metoden är inte applicerbar i alla regioner utan kalibrering eftersom den är anpassade till förhållande i Stockholmsregion. Arbetet med att utforma den mest optimala och effektiva bussterminalen kommer att fortsätta i takt med att metoderna blir bättre på att identifiera och fastställa de uppställningsplatser som behövs. Detta är ett arbete där teoretiska studier kommer att kombineras med erfarenhet och kunskapsöverföring.
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| 5. |
- Al-Tikriti, Yassir
(author)
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Microgels as drug delivery vehicles : loading and release of amphiphilic drugs
- 2022
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Doctoral thesis (other academic/artistic)abstract
- Polyelectrolyte microgels are used as delivery vehicles for amphiphilic drugs in, e.g., treatments of liver cancer by a method called trans-arterial chemoembolization. The thesis deals with fundamental properties of such delivery systems related to the self-assembling properties of the drug molecules and their interaction with the charged polymer network of the microgel. The main objective was to establish mechanistic models describing the loading and release of drugs under relevant conditions. For that purpose experimental techniques providing thermodynamic, compositional and microstructural information were used to elucidate how the kinetics depend on the stability of the drug self-assemblies and the volume response of the microgels. Micromanipulator-assisted microscopy studies showed that negatively charged microgels phase separated during loading and release of cationic amphiphilic drugs. At intermediate loading levels the drug aggregates and part of the network formed a collapsed phase coexisting with a swollen, drug-lean phase. In particular, during release in a medium of physiological ionic strength, the drug-lean phase formed a depletion layer (shell) surrounding a drug-rich core. Investigations of a series of drugs with different molecular architectures showed that the drug release rate was determined mainly by the stability of the drug aggregates in the core and the diffusive mass transport of drug molecules through the shell. Detailed studies of polyacrylate microgels interacting with amitriptyline hydrochloride showed that swelling of the shell network greatly influenced the release rate. Furthermore, experiments with a specially constructed microscopy cell was used to establish that the collapsed and swollen phases could coexist in equilibrium, and that the swelling of the network in the swollen phase depended on the proportion between them when present in the same microgel. The latter effect was related to the elastic coupling between the phases. Confocal Raman microscopy was employed to demonstrate, for the first time, the related elastic effect, that the concentration of amitriptyline in the swollen phase decreased with increasing proportion of the collapsed phase. Small-angle X-ray scattering showed that the collapsed phase had a disordered microstructure of drug micelles with ellipsoidal shape. The aggregation number increased with increasing concentration of drug in the microgel, most likely by incorporating the uncharged base form. By providing detailed information about thermodynamic properties and microstructures, the results of the thesis provide a basis for rational design of microgel drug delivery systems.
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| 7. |
- Cook, Jackie, et al.
(author)
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Mass Screening and Treatment on the Basis of Results of a Plasmodium falciparum-Specific Rapid Diagnostic Test Did Not Reduce Malaria Incidence in Zanzibar
- 2015
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In: The Internet Journal of Infectious Diseases. - : Oxford University Press (OUP). - 1528-8366 .- 0022-1899 .- 1537-6613. ; 211:9, s. 1476-1483
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Journal article (peer-reviewed)abstract
- BACKGROUND: Seasonal increases in malaria continue in hot spots in Zanzibar. Mass screening and treatment (MSAT) may help reduce the reservoir of infection; however, it is unclear whether rapid diagnostic tests (RDTs) detect a sufficient proportion of low-density infections to influence subsequent transmission.METHODS: Two rounds of MSAT using Plasmodium falciparum-specific RDT were conducted in 5 hot spots (population, 12 000) in Zanzibar in 2012. In parallel, blood samples were collected on filter paper for polymerase chain reaction (PCR) analyses. Data on confirmed malarial parasite infections from health facilities in intervention and hot spot control areas were monitored as proxy for malaria transmission.RESULTS: Approximately 64% of the population (7859) were screened at least once. P. falciparum prevalence, as measured by RDT, was 0.2% (95% confidence interval [CI], .1%-.3%) in both rounds, compared with PCR measured prevalences (for all species) of 2.5% (95% CI, 2.1%-2.9%) and 3.8% (95% CI, 3.2%-4.4%) in rounds 1 and 2, respectively. Two fifths (40%) of infections detected by PCR included non-falciparum species. Treatment of RDT-positive individuals (4% of the PCR-detected parasite carriers) did not reduce subsequent malaria incidence, compared with control areas.CONCLUSIONS: Highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT an effective strategy in settings where malaria elimination programs are in the pre-elimination phase.
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| 8. |
- Einarsdottir, Sigrun, et al.
(author)
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Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity.
- 2022
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In: Blood advances. - : American Society of Hematology. - 2473-9537 .- 2473-9529. ; 6:9, s. 2723-2730
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Journal article (peer-reviewed)abstract
- Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for hematological diseases are at risk of severe disease and death from COVID-19. To determine the safety and immunogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines, samples from 50 infection-naive allo-HSCT recipients (median, 92 months from transplantation, range, 7-340 months) and 39 healthy controls were analyzed for serum immunoglobulin G (IgG) against the receptor binding domain (RBD) within spike 1 (S1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; anti-RBD-S1 IgG) and for SARS-CoV-2-specific T-cell immunity, reflected by induction of T-cell-derived interferon-γ in whole blood stimulated ex vivo with 15-mer SI-spanning peptides with 11 amino acid overlapS1-spanning peptides. The rate of seroconversion was not significantly lower in allo-transplanted patients than in controls with 24% (12/50) and 6% (3/50) of patients remaining seronegative after the first and second vaccination, respectively. However, 58% of transplanted patients lacked T-cell responses against S1 peptides after 1 vaccination compared with 19% of controls (odds ratio [OR] 0.17; P = .009, Fisher's exact test) with a similar trend after the second vaccination where 28% of patients were devoid of detectable specific T-cell immunity, compared with 6% of controls (OR 0.18; P = .02, Fisher's exact test). Importantly, lack of T-cell reactivity to S1 peptides after vaccination heralded substandard levels (<100 BAU/mL) of anti-RBD-S1 IgG 5 to 6 months after the second vaccine dose (OR 8.2; P = .007, Fisher's exact test). We conclude that although allo-HSCT recipients achieve serum anti-RBD-S1 IgG against SARS-CoV-2 after 2 vaccinations, a deficiency of SARS-CoV-2-specific T-cell immunity may subsequently translate into insufficient humoral responses.
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| 9. |
- Fagerberg, Jonas H., et al.
(author)
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Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid
- 2012
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In: Molecular Pharmaceutics. - : American Chemical Society (ACS). - 1543-8384 .- 1543-8392. ; 9:7, s. 1942-1952
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Journal article (peer-reviewed)abstract
- Ethanol intake can lead to an unexpected and possibly problematic increase in the bioavailability of druglike compounds. In this work we investigated the effect of ethanol on the apparent solubility and dissolution rate of poorly soluble compounds in simulated intestinal fluid representing a preprandial state. A series of 22 structurally diverse, poorly soluble compounds were measured for apparent solubility and intrinsic dissolution rate (37 degrees C) in phosphate buffer pH 6.5 (PhB6.5) and fasted state simulated intestinal fluid (FaSSIF, pH 6.5) with and without ethanol at 5% v/v or 20% v/v. The obtained data were used to understand for which molecules ethanol results in an increased apparent solubility and, therefore, may increase the amount of drug absorbed. In FaSSIF(20%ethanol) 59% of the compounds displayed >3-fold higher apparent solubility than in pure FaSSIF, whereas the effects of 5% ethanol on solubility, in most cases, were negligible. Acidic and neutral compounds were more solubilized by the addition of ethanol than by lecithin/taurocholate aggregates, whereas bases showed a more substance-specific response to the additives in the buffer. The stronger solubilizing capacity of ethanol as compared to the mixed lipid aggregates in FaSSIF was further identified through Spearman rank analyses, which showed a stronger relationship between FaSSIF(20%ethanol) and PhB6.5,20%ethanol (r(S) of 0.97) than FaSSIF(20%ethanol) and FaSSIF (r(S) of 0.86). No relationships were found between solubility changes in media containing ethanol and single physicochemical properties, but multivariate data analysis showed that inclusion of ethanol significantly reduced the negative effect of compound lipophilicity on solubility. For this data set the higher concentration of ethanol gave a dose number (Do) <1 for 30% of the compounds that showed incomplete dissolution in FaSSIF. Significant differences were shown in the melting point, lipophilicity, and dose profiles between the compounds having a Do < 1 and Do > 1, with the latter having higher absolute values in all three parameters. In conclusion, this study showed that significant effects of ethanol on apparent solubility in the preprandial state can be expected for lipophilic compounds. The results herein indicate that acidic and neutral compounds are more sensitive to the addition of ethanol than to the mixed lipid aggregates present in the fasted intestine.
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| 10. |
- Khalaf, Atika, 1973-, et al.
(author)
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Undernutrition risk, overweight/obesity, and nutritional care in relation to undernutrition risk among inpatients in southwestern Saudi Arabia : a hospital-based point prevalence study
- 2011
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In: Journal of Nutritional Disorders & Therapy. ; 1:2, s. 104-
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Journal article (peer-reviewed)abstract
- Background: Undernutrition is a problem in institutional care, where 20–46% of all inpatients are classified as being “at nutritional risk”. This study explores the prevalence of undernutrition risk and overweight/obesity and the targeting of nutritional care in relation to undernutrition risk among inpatients in southwestern Saudi Arabia. Methods: A cross-sectional, point prevalence study was carried out in a Central hospital in southwestern Saudi Arabia. The subjects were inpatients, over the age of 18 who had their nutritional status assessed. Moderate/high undernutrition risk was defined as the occurrence of at least two of: weight loss, low BMI, and/or eating difficulties. Overweight/obesity was graded by using Caucasian and Asian cut-offs for BMI. Results: Out of 219 patients 166 (76%) agreed to participate (106 men and 60 women) with a significantly higher drop-out among women (n=35, 37% vs. men n=18, 14%). There was no significant difference in the prevalence of moderate/high undernutrition risk between men and women (40% vs. 38%) but more women (29% or 40%, depending on cut-off) than men (10% or 23%) were obese. Among patients at moderate/high undernutrition risk, more women (61%) than men (31%) were served small portions. Conclusions: There is a need to increase awareness about nutrition among nurses, to implement nutritional guidelines and to do more research regarding overweight/obesity among the female population. Motivational strategie need to be developed to focus on increasing the Saudi female participation in research.
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| 11. |
- Khalaf, Atika, et al.
(author)
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Undernutrition risk, overweight/obesity, and nutritional care in relation to undernutrition risk among inpatients in southwestern Saudi Arabia : a hospital-based point prevalence study
- 2011
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In: Journal of Nutritional Disorders & Therapy. ; 1:2
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Journal article (peer-reviewed)abstract
- Background: Undernutrition is a problem in institutional care, where 20–46% of all inpatients are classified as being “at nutritional risk”. This study explores the prevalence of undernutrition risk and overweight/obesity and the targeting of nutritional care in relation to undernutrition risk among inpatients in southwestern Saudi Arabia. Methods: A cross-sectional, point prevalence study was carried out in a Central hospital in southwestern Saudi Arabia. The subjects were inpatients, over the age of 18 who had their nutritional status assessed. Moderate/high undernutrition risk was defined as the occurrence of at least two of: weight loss, low BMI, and/or eating difficulties. Overweight/obesity was graded by using Caucasian and Asian cut-offs for BMI. Results: Out of 219 patients 166 (76%) agreed to participate (106 men and 60 women) with a significantly higher drop-out among women (n=35, 37% vs. men n=18, 14%). There was no significant difference in the prevalence of moderate/high undernutrition risk between men and women (40% vs. 38%) but more women (29% or 40%, depending on cut-off) than men (10% or 23%) were obese. Among patients at moderate/high undernutrition risk, more women (61%) than men (31%) were served small portions. Conclusions: There is a need to increase awareness about nutrition among nurses, to implement nutritional guidelines and to do more research regarding overweight/obesity among the female population. Motivational strategie need to be developed to focus on increasing the Saudi female participation in research.
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| 13. |
- Ramseier, Christoph A, et al.
(author)
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Consensus Report: 2nd European Workshop on Tobacco Use Prevention and Cessation for Oral Health Professionals.
- 2010
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In: International dental journal. - 0020-6539. ; 60:1, s. 3-6
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Journal article (peer-reviewed)abstract
- Tobacco use has been identified as a major risk factor for oral disorders such as cancer and periodontal disease. Tobacco use cessation (TUC) is associated with the potential for reversal of precancer, enhanced outcomes following periodontal treatment, and better periodontal status compared to patients who continue to smoke. Consequently, helping tobacco users to quit has become a part of both the responsibility of oral health professionals and the general practice of dentistry. TUC should consist of behavioural support, and if accompanied by pharmacotherapy, is more likely to be successful. It is widely accepted that appropriate compensation of TUC counselling would give oral health professionals greater incentives to provide these measures. Therefore, TUC-related compensation should be made accessible to all dental professionals and be in appropriate relation to other therapeutic interventions. International and national associations for oral health professionals are urged to act as advocates to promote population, community and individual initiatives in support of tobacco use prevention and cessation (TUPAC) counselling, including integration in undergraduate and graduate dental curricula. In order to facilitate the adoption of TUPAC strategies by oral health professionals, we propose a level of care model which includes 1) basic care: brief interventions for all patients in the dental practice to identify tobacco users, assess readiness to quit, and request permission to re-address at a subsequent visit, 2) intermediate care: interventions consisting of (brief) motivational interviewing sessions to build on readiness to quit, enlist resources to support change, and to include cessation medications, and 3) advanced care: intensive interventions to develop a detailed quit plan including the use of suitable pharmacotherapy. To ensure that the delivery of effective TUC becomes part of standard care, continuing education courses and updates should be implemented and offered to all oral health professionals on a regular basis.
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| 14. |
- Said Al-Kharusi, Enass, et al.
(author)
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Mapping conservation priorities in alpine and subartctic Swedish lakes affected by rapid climate change
- 2018
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Conference paper (other academic/artistic)abstract
- Swedish alpine and subarctic areas undergo rapid transitions due to climate change, especially in relatively humid areas where the forest vegetation is expanding. It has been suggested that lakes in these areas are in transition from clearwater into brownwater state, because of the humus layer building up in surrounding soils, with negative consequences, e.g., for the biomass production of zooplankton and fish. However, this idea remains a hypothesis to be tested at a large scale. We used the new high-resolution satellite Sentinel-2 to evaluate the relationship between lake color and forest succession in 250 widely distributed lakes across Sweden. Preliminary results show that lakes remain surprisingly clear in areas of recent forest expansion, suggesting that there is lag time before brownification occurs. Our study could be used to map regions that are sensitive to future water brownification.
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| 15. |
- Uhlén, Mathias, et al.
(author)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Journal article (peer-reviewed)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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