| 1. |
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| 2. |
- Leonov, A. A., et al.
(author)
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Separation of electrons and protons in the GAMMA-400 gamma-ray telescope
- 2015
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In: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 56:7, s. 1538-1545
-
Journal article (peer-reviewed)abstract
- The GAMMA-400 telescope will measure the fluxes of gamma rays and cosmic-ray electrons and positrons in the energy range from 100 MeV to several TeV. These measurements will allow it to achieve the following scientific objectives: search for signatures of dark matter, investigation of gamma-ray point-like and extended sources, study of the energy spectrum of the Galactic and extragalactic diffuse emission, study of gamma-ray bursts and gamma-ray emission from the active Sun, together with high-precision measurements of the high-energy electrons and positrons spectra, protons and nuclei up to the knee. The bulk of cosmic rays are protons and helium nuclei, whereas the lepton component in the total flux is similar to 10(-3) at high energy. In the present paper, the simulated capability of the GAMMA-400 telescope to distinguish electrons and positrons from protons in cosmic rays is addressed. The individual contribution to the proton rejection from each detector system of GAMMA-400 is studied separately. The use of the combined information from all detectors allows us to reach a proton rejection of the order of similar to 4 x 10(5) for vertical incident particles and similar to 3 x 10(5) for particles with initial inclination of 30 degrees in the electron energy range from 50 GeV to 1 TeV. (C) 2015 COSPAR.
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| 3. |
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| 4. |
- Adiels, Lars, 1952-, et al.
(author)
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Test of CP violation with K0 and K‾0 at LEAR
- 1985
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In: Physics with antiprotons at LEAR in the ACOL era. - Gif sur Yvette : Editions Frontières. - 2863320351 ; , s. 467-482
-
Conference paper (other academic/artistic)
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| 5. |
- Andres, E., et al.
(author)
-
AMANDA : Status, results and future
- 1999
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In: Proceedings, 8th International Workshop, Venice, Italy, February 23-26, 1999. Vol. 1, 2. ; , s. 63-79
-
Conference paper (peer-reviewed)abstract
- We review the status of the AMANDA neutrino telescope. We present resultsobtained from the four-string prototype array AMANDA-B4 and describe themethods of track reconstruction and neutrino event separation. We give also firstresults of the analysis of the 10-string detector AMANDA-B10, in particular onatmospheric neutrinos and the search for magnetic monopoles. We sketch thefuture schedule on the way to a cube kilometer telescope at the South Pole,ICECUBE.
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| 6. |
- van der Valk, Ralf J P, et al.
(author)
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A novel common variant in DCST2 is associated with length in early life and height in adulthood.
- 2015
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In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 24:4, s. 1155-68
-
Journal article (peer-reviewed)abstract
- Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
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| 7. |
- Andrés, E. C., et al.
(author)
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The AMANDA neutrino telescope
- 1999
-
In: Nuclear physics B, Proceedings supplements. - 0920-5632 .- 1873-3832. ; 77:1-3, s. 474-485
-
Journal article (peer-reviewed)abstract
- With an effective telescope area of order 104 m2 for TeV neutrinos, a threshold near ∼50 GeV and a pointing accuracy of 2.5 degrees per muon track, the AMANDA detector represents the first of a new generation of high energy neutrino telescopes, reaching a scale envisaged over 25 years ago. We describe early results on the calibration of natural deep ice as a particle detector as well as on AMANDA's performance as a neutrino telescope.
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| 8. |
- Andrés, E., et al.
(author)
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Observation of high-energy neutrinos using Čerenkov detectors embedded deep in Antarctic ice
- 2001
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 410:6827, s. 441-443
-
Journal article (peer-reviewed)abstract
- Neutrinos are elementary particles that carry no electric charge and have little mass. As they interact only weakly with other particles, they can penetrate enormous amounts of matter, and therefore have the potential to directly convey astrophysical information from the edge of the Universe and from deep inside the most cataclysmic high-energy regions. The neutrino's great penetrating power, however, also makes this particle difficult to detect. Underground detectors have observed low-energy neutrinos from the Sun and a nearby supernova2, as well as neutrinos generated in the Earth's atmosphere. But the very low fluxes of high-energy neutrinos from cosmic sources can be observed only by much larger, expandable detectors in, for example, deep water3,4 or ice5. Here we report the detection of upwardly propagating atmospheric neutrinos by the ice-based Antarctic muon and neutrino detector array (AMANDA). These results establish a technology with which to build a kilometre-scale neutrino observatory necessary for astrophysical observations1.
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| 9. |
- Andrés, E., et al.
(author)
-
Recent results from AMANDA
- 2001
-
In: International Journal of Modern Physics A. - 0217-751X .- 1793-656X. ; 16:1C, s. 1013-1015
-
Journal article (peer-reviewed)abstract
- We present results based on data taken in 1997 with the 302-PMT Antarctic Muon and Neutrino Detector Array-B10 ("AMANDA-B10") array. Atmospheric neutrinos created in the northern hemisphere are observed indirectly through their charged current interactions which produce relativistic, Cherenkov-light-emitting upgoing muons in the South Pole ice cap. The reconstructed angular distribution of these events is in good agreement with expectation and demonstrates the viability of this ice-based device as a neutrino telescope.
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| 10. |
- Andres, E., et al.
(author)
-
Results from the AMANDA high energy neutrino detector
- 2000
-
In: Nuclear physics B, Proceedings supplements. - : Elsevier. - 0920-5632 .- 1873-3832. ; 91:1-3, s. 423-430
-
Journal article (peer-reviewed)abstract
- This paper briefly summarizes the search for astronomical sources of high-energy neutrinos using the AMANDA-B10 detector. The complete data set from 1997 was analyzed. For Eμ > 10 TeV, the detector exceeds 10,000 m2 in effective area between declinations of 25 and 90 degrees. Neutrinos generated in the atmosphere by cosmic ray interactions were used to verify the overall sensitivity of the detector. The absolute pointing accuracy and angular resolution has been confirmed by the analysis of coincident events between the SPASE air shower array and the AMANDA detector. Preliminary flux limits from point source candidates are presented. For declinations larger than +45 degrees, our results compare favorably to existing limits for sources in the Southern sky. We also present the current status of the searches for high energy neutrino emission from diffusely distributed sources, GRBs, and WIMPs from the center of the earth.
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| 11. |
- Bai, X., et al.
(author)
-
Status of the Neutrino Telescope AMANDA : Monopoles and WIMPS
- 2001
-
In: Dark Matter in Astro- and Particle Physics. - Berlin, Heidelberg : Springer. - 9783642626081 ; , s. 699-706
-
Conference paper (peer-reviewed)abstract
- The neutrino telescope AMANDA has been set up at the geographical South Pole as first step to a neutrino telescope of the scale of one cubic kilometer, which is the canonical size for a detector sensitive to neutrinos from Active Galactic Nuclei (AGN), Gamma Ray Bursts (GRB) and Topological Defects (TD). The location and depth in which the detector is installed is given by the requirement to detect neutrinos by the Cherenkov light produced by their reaction products and to keep the background due to atmospheric muons as small as possible. However, a detector optimized for this purpose is also capable to detect the bright Cherenkov light from relativistic Monopoles and neutrino signals from regions with high gravitational potential, where WIMPS are accumulated and possibly annihilate. Both hypothetical particles might contribute to the amount of dark matter. Therefore here a report about the status of the experiment (autumn 2000) and about the status of the search for these particles with the AMANDA B10 sub-detector is given.
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| 12. |
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| 13. |
- Edsjö, Joakim, et al.
(author)
-
WIMP searches with AMANDA-B10
- 2001
-
In: The Identification Of Dark Matter. - : World Scientific. - 9789810246020 ; , s. 499-505
-
Book chapter (other academic/artistic)
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| 14. |
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| 15. |
- Jensen, I-B, et al.
(author)
-
The AHA-study: Implementing evidence based measueres for retaining workability at work sites : Effects on lifestyle, workability and firm productivity. 9th International Congress of Behavioral Medicine. Bangkok, Thailand, Nov 29-Dec 2, 2006
- 2006
-
Conference paper (other academic/artistic)abstract
- Jensen IB, Bergstrom G, Bjorklund C, Fried I, Lisspers J, Nathell L, Hermansson U, Roos P, Bodin L, the AHAstudy group (2006). The AHA-study: Implementing evidence based measueres for retaining workability at work sites - Effcets on lifestyle, workability and firm productivity. Presented at the 9th International Congress of Behavioral Medicine. Bangkok, Thailand, Nov 29-Dec 2, 2006.
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| 16. |
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| 17. |
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| 18. |
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| 19. |
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| 20. |
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| 21. |
- Merid, Simon Kebede, et al.
(author)
-
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
- 2020
-
In: Genome Medicine. - Stockholm : Karolinska Institutet, Dept of Clinical Science and Education, Södersjukhuset. - 1756-994X.
-
Journal article (peer-reviewed)abstract
- Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10- 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Romania, P., et al.
(author)
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Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion
- 2017
-
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 20:4, s. 846-853
-
Journal article (peer-reviewed)abstract
- Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 30 UTR, preserves ERAP1 from miR-UL1125p-mediated degradation. Specifically, HCMV miRUL112-5p binds the 30 UTR of ERAP1 A variant, but not the 30 UTR of ERAP1 G variant, and, accordingly, ERAP1 expression is reduced both at RNA and protein levels only in human fibroblasts homozygous for the A variant. Consistently, HCMV-infected GG fibroblasts were more efficient in trimming viral antigens and being lysed by HCMV-peptide-specific CTLs. Notably, a significantly decreased HCMV seropositivity was detected among GG individuals suffering from multiple sclerosis, a disease model in which HCMV is negatively associated with adultonset disorder. Overall, our results identify a resistance mechanism to HCMV miR-UL112-5p-based immune evasion strategy with potential implications for individual susceptibility to infection and other diseases.
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| 26. |
- Uphoff, EP, et al.
(author)
-
Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe
- 2017
-
In: ERJ open research. - : European Respiratory Society (ERS). - 2312-0541. ; 3:3
-
Journal article (peer-reviewed)abstract
- While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe.We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education, parental smoking, pets, parental asthma, doctor-diagnosed allergic rhinitis, doctor-diagnosed eczema and wheeze severity.At age 4 years, asthma prevalence varied from 1.72% in Germany to 13.48% in England and the prevalence of wheeze varied from 9.82% in Greece to 55.37% in Spain. Adjusted estimates of the proportion of 4-year-old children with wheeze diagnosed with asthma remained highest in England (38.14%, 95% CI 31.38–44.90%) and lowest in Spain (15.94%, 95% CI 6.16–25.71%).The large differences in prevalence rates of asthma, wheeze and wheeze with asthma at age 4 years between European cohorts may indicate that childhood asthma is more readily diagnosed in some countries while going unrecognised elsewhere.
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| 27. |
- Wilson, A. N., et al.
(author)
-
Magnetic dipole bands in 190Hg : First evidence of excitations across the Z = 82 sub-shell in Hg nuclei
- 2001
-
In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 505:1-4, s. 6-14
-
Journal article (peer-reviewed)abstract
- An experiment aimed at studying high-spin states in 190Hg was performed with the Eurogam II array. The data have revealed the presence of cascades of magnetic dipole transitions with some unexpected properties. Unlike the MI bands previously observed in the heavier Hg isotopes, these structures have extremely large B(M1)/B(E2) ratios, The observation of a third dipole band with much lower B(M1)/B(E2) values in the same spin/excitation energy regime suggests that the bands may represent configurations occurring in different minima in the potential energy surface. Configuration-dependent Cranked Nilsson-Strutinsky calculations predict the presence of a minimum in the nuclear potential energy surface at a deformation of ε ≅ 0.2, γ ≅ -90°, occurring when a proton is excited across the Z = 82 shell-gap into an h9/2 orbital. It is suggested that the bands exhibiting anomalously large B(M1)/B(E2) ratios may be associated with this minimum.
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| 28. |
- Wischnewski, R., et al.
(author)
-
The AMANDA neutrino detector : Status report
- 2000
-
In: Nuclear physics B, Proceedings supplements. - 0920-5632 .- 1873-3832. ; 85:1-3, s. 141-145
-
Journal article (peer-reviewed)abstract
- The first stage of the AMANDA High Energy Neutrino Detector at the South Pole, the 302 PMT array AMANDA-B10, is taking data since 1997. We describe results on atmospheric neutrinos, limits on indirect WIMP detection, seasonal muon flux variation, relativistic monopole flux limits, a search for gravitational collapse neutrinos, and a depth scan of the optical ice properties. The next stage 19-string detector AMANDA-II with ∼650 PMTs will be completed in spring 2000.
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| 29. |
- Abdelmagid, N., et al.
(author)
-
Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis
- 2016
-
In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5
-
Journal article (peer-reviewed)abstract
- Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certain individuals develop HSE. Here we explore potential host genetic variants predisposing to HSE. In order to investigate this we used a rat HSE model comparing the HSE susceptible SHR (Spontaneously Hypertensive Rats) with the asymptomatic infection of BN (Brown Norway). Notably, both strains have HSV-1 spread to the CNS at four days after infection. A genome wide linkage analysis of 29 infected HXB/BXH RILs (recombinant inbred lines-generated from the prior two strains), displayed variable susceptibility to HSE enabling the definition of a significant QTL (quantitative trait locus) named Hse6 towards the end of chromosome 4 (160.89-174Mb) containing the Vwf (von Willebrand factor) gene. This was the only gene in the QTL with both cis-regulation in the brain and included several non-synonymous SNPs (single nucleotide polymorphism). Intriguingly, in human chromosome 12 several SNPs within the intronic region between exon 43 and 44 of the VWF gene were associated with human HSE pathogenesis. In particular, rs917859 is nominally associated with an odds ratio of 1.5 (95% CI 1.11-2.02; p-value = 0.008) after genotyping in 115 HSE cases and 428 controls. Although there are possibly several genetic and environmental factors involved in development of HSE, our study identifies variants of the VWF gene as candidates for susceptibility in experimental and human HSE.
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| 30. |
- Adiels, Lars, et al.
(author)
-
A π0 and η spectrometer of lead glass and BGO for momenta up to 1 GeV/c
- 1986
-
In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 244:3, s. 380-390
-
Journal article (peer-reviewed)abstract
- A spectrometer consisting of two sets of bismuth germanium oxide (BGO) crystals and a lead-glass array has been used to measure the [pi]0 and [eta] momentum spectra produced from proton-antiproton annihilations at rest. We describe the test of the BGO sets in electron beams of energies from 50 to 450 MeV. We discuss the method of construction and calibration of the lead-glass array, as well as procedures to extract the energy and position resolutions for detected photons. A momentum resolution ([sigma]) for [pi]0’s and [eta]’s of 4% and 3%, respectively has been achieved at momenta below 1 GeV/c.
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| 31. |
- Adiels, L., et al.
(author)
-
Experimental determination of the branching ratios {Mathematical expression}, and 2γ at rest
- 1987
-
In: Zeitschrift für Physik C Particles and Fields. - : Springer. - 0170-9739 .- 1431-5858. ; 35:1, s. 15-19
-
Journal article (peer-reviewed)abstract
- The branching ratios of {Mathematical expression} annihilations into the neutral final states 2π 0, π 0γ, and 2γ are measured by stopping antiprotons in liquid hydrogen. They are {Mathematical expression}, {Mathematical expression}, and B γγ<1.7×10 -6 (95% c.l.).
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| 32. |
- Adiels, L., et al.
(author)
-
Experimental determination of the branching ratios proton-antiproton -> 2pi0, pi0γ and γγ at rest
- 1987
-
In: Zeitschrift für Physik C Particles and Fields. - 0170-9739. ; 35:1, s. 15-19
-
Journal article (peer-reviewed)abstract
- The branching ratios of Mathematical expression annihilations into the neutral final states 2π0, π0γ, and 2γ are measured by stopping antiprotons in liquid hydrogen. They are Mathematical expression, Mathematical expression, and Bγγ<1.7×10-6 (95% c.l.). © 1987 Springer-Verlag.
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| 33. |
- Adiels, L., et al.
(author)
-
Experimental study of the inclusive η-spectrum from p {Mathematical expression} annihilations at rest in liquid hydrogen
- 1989
-
In: Zeitschrift für Physik C Particles and Fields. - : Springer. - 0170-9739 .- 1431-5858. ; 42:1, s. 49-58
-
Journal article (peer-reviewed)abstract
- The inclusive η-momentum spectrum from {Mathematical expression} annihilations at rest in liquid hydrogen was measured at LEAR. Branching ratios were obtained for {Mathematical expression}, and ηη(8.1±3.1)×10 -5. An upper limit for {Mathematical expression} of 1.8×10 -4 at 95% CL was found. The ratio of the branching ratios is BR(ηρ{variant})/BR(ηω)=0.51 -0.06 +0.20. For the ratio of branching ratios into two pseudoscalar mesons, we have BR(ηπ 0)/BR(π 0π 0)=0.65±0.14, BR(ηη)/BR(π 0π 0), BR(ηη ′)/BR(π 0π 0) at 95% CL, and BR(ηη)/BR(ηπ 0). © 1989 Springer-Verlag.
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| 34. |
- Adiels, Lars, et al.
(author)
-
Experimental study of the inclusive η-spectrum from proton-antiproton annihilations at rest in liquid hydrogen
- 1989
-
In: Zeitschrift für Physik C Particles and Fields. - 0170-9739 .- 1431-5858. ; 42, s. 49-58
-
Journal article (peer-reviewed)abstract
- The inclusive η-momentum spectrum from Mathematical expression annihilations at rest in liquid hydrogen was measured at LEAR. Branching ratios were obtained for Mathematical expression, and ηη(8.1±3.1)×10-5. An upper limit for Mathematical expression of 1.8×10-4 at 95% CL was found. The ratio of the branching ratios is BR(ηÏvariant)/BR(ηω)=0.51-0.06+0.20. For the ratio of branching ratios into two pseudoscalar mesons, we have BR(ηπ0)/BR(Ï€0Ï€0)=0.65±0.14, BR(ηη)/BR(Ï€0Ï€0), BR(ηη′)/BR(Ï€0Ï€0) at 95% CL, and BR(ηη)/BR(ηπ0). © 1989 Springer-Verlag.
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| 35. |
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| 36. |
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| 37. |
- Adiels, L., et al.
(author)
-
Pi0 and eta spectra from proton-antiproton annihilations at rest
- 1984
-
In: Zeitschrift für Physik. C, Particles and fields. - 0170-9739. ; 21:4, s. 315-319
-
Journal article (peer-reviewed)abstract
- The low-energy part of the Ï€0 spectrum associated with Mathematical expression annihilation at rest was measured in order to search for bound baryonium-like states. The upper limit for reaching such states via the emission of monochromatic Ï€0’s was found to be 8% per annihilation in the mass region of 1650 MeV. The low-energy part of the η spectrum from Mathematical expression annihilations at rest was also observed.
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| 38. |
- Adiels, L., et al.
(author)
-
Search for narrow exotic states in annihilations on 4He
- 1984
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 138:1-3, s. 235-240
-
Journal article (peer-reviewed)abstract
- After having found evidence for narrow exotic states in p annihilation, the production of such states on a nuclear target was studied with similar techniques. The γ spectrum associated with annihilation on 4He at rest was measured. The spectrum shows two peaks, at energies of 161.9 and 203.0 MeV, corresponding to intermediate narrow states of masses which seem to be related to states found in p annihilations. The confidence is better than 4 σ.
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| 39. |
- Adiels, L., et al.
(author)
-
Search for narrow signals in the [gamma]-spectrum from [Proton-antiproton] annihilation at rest
- 1986
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 182:3-4, s. 405-408
-
Journal article (peer-reviewed)abstract
- The [gamma]-spectrum originating from pp[combining macron] annihilations at rest in liquid hydrogen was measured with two BGO spectrometers. A total of 24 ï¿œ 106[gamma]’s were accumulated. No narrow peaks indicating exotic states such as baryonium were observed. The upper limit for the branching ratio with 1040 [less-than-or-equals, slant] mx [less-than-or-equals, slant] 1770 MeV/c2 and with [lambda]x [less-than-or-equals, slant] 25 MeV/c2 is less than 10-3 with more than 99.96% confidence.
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| 40. |
- Adiels, L., et al.
(author)
-
Search for narrow signals in the γ-spectrum from pp̄ annihilation at rest
- 1986
-
In: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 182:3-4, s. 405-408
-
Journal article (peer-reviewed)abstract
- The γ-spectrum originating from pp̄ annihilations at rest in liquid hydrogen was measured with two BGO spectrometers. A total of 24 × 10 6 γ's were accumulated. No narrow peaks indicating exotic states such as baryonium were observed. The upper limit for the branching ratio p p ̄ → γ + X with 1040 ≤ m x ≤ 1770 MeV/c 2 and with λ x ≤ 25 MeV/c 2 is less than 10 -3 with more than 99.96% confidence. © 1986.
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| 41. |
- Adiels, L, et al.
(author)
-
Some results of experiment PS182 at LEAR
- 1986
-
In: Antiproton 86. - Singspore : World Scientific Publishing. - 9971503131 ; , s. 199-204, s. 199-204
-
Conference paper (other academic/artistic)
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| 42. |
- Adiels, L, et al.
(author)
-
π0 and η spectroscopy at LEAR
- 1985
-
In: Physics with antiprotons at LEAR in the ACOL era. - Gif sur Yvette : Editions Frontières. - 2863320351 ; , s. 359-360
-
Conference paper (other academic/artistic)
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| 43. |
- Akre [Fall], Katja, 1971-, et al.
(author)
-
Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement
- 2000
-
In: Cancer Research. - Birmingham, USA : American Asoociation for Cancer Research. - 0008-5472 .- 1538-7445. ; 60, s. 6376-
-
Journal article (peer-reviewed)abstract
- Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationwide case-control study nested in a cohort of 39,154 patients who underwent hip replacement surgery between 1965 and 1983. Such patients frequently receive prophylactic antibiotic treatment. During follow-up through 1989, we identified 189 incident cases of gastric cancer. For each case, three controls were selected from the cohort. Exposure data were abstracted from hospital records. Blood samples from a separate cohort undergoing hip replacement surgery were analyzed for anti-H. pylori IgG before and after surgery. Both long-term antibiotic treatment before surgery [odds ratio (OR), 0.3; 95% confidence interval (CI), 0.1-0.7] and prophylactic antibiotic treatment (OR, 0.7; 95% CI, 0.5-1.1) conferred a reduction in gastric cancer risk. The reduction appeared stronger after 5 years (OR, 0.6; 95% CI, 0.3-1.2) than during shorter follow-up after hip replacement (OR, 0.8; 95% CI, 0.4-1.7). There was an apparent decrease in risk with increasing body weight-adjusted doses of antibiotics (P = 0.13). However, the rate of H. pylori antibody disappearance was not strikingly higher in the cohort of patients undergoing hip replacement than in a control cohort. Our findings provide indirect support for the hypothesis that treatment with antibiotics at a relatively advanced age reduces the risk of gastric cancer.
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| 44. |
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| 45. |
- Andersson, Maria, et al.
(author)
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Coinfection with Enteric Pathogens in East African Children with Acute Gastroenteritis-Associations and Interpretations
- 2018
-
In: American Journal of Tropical Medicine and Hygiene. - : American Society of Tropical Medicine and Hygiene. - 0002-9637 .- 1476-1645. ; 98:6, s. 1566-1570
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Journal article (peer-reviewed)abstract
- Enteric coinfections among children in low-income countries are very common, but it is not well known if specific pathogen combinations are associated or have clinical importance. In this analysis, feces samples from children in Rwanda and Zanzibar less than 5 years of age, with (N = 994) or without (N = 324) acute diarrhea, were analyzed by realtime polymerase chain reaction targeting a wide range of pathogens. Associations were investigated by comparing codetection and mono-detection frequencies for all pairwise pathogen combinations. More than one pathogen was detected in 840 samples (65%). A negative association (coinfections being less common than expected from probability) was observed for rotavirus in combination with Shigella, Campylobacter, or norovirus genogroup II, but only in patients, which is statistically expected for agents that independently cause diarrhea. A positive correlation was observed, in both patients and controls, between Ct (threshold cycle) values for certain virulence factor genes in enteropathogenic Escherichia coli (EPEC) (eae and bfpA) and toxin genes in enterotoxigenic E. coli (eltB and estA), allowing estimation of how often these genes were present in the same bacteria. A significant positive association in patients only was observed for Shigella andEPEC-eae, suggesting that this coinfection might interact in a manner that enhances symptoms. Although interaction between pathogens that affect symptoms is rare, this work emphasizes the importance and difference in interpretation of coinfections depending on whether they are positively or negatively associated.
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| 46. |
- Andreadis, Ioannis I., et al.
(author)
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Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations
- 2023
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In: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 189
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Journal article (peer-reviewed)abstract
- Solid lipid-based formulations (sLBFs) have the potential to increase the oral bioavailability of drugs with poor solubility in water, while counteracting some of the disadvantages of liquid LBFs. The most common experimental set-up to study the performance of LBFs in vitro is the lipolysis assay, during which the LBFs are digested by lipases in an environment mimicking the human small intestine. However, this assay has failed in many cases to correctly predict the performance of LBFs in vivo, highlighting the need for new and improved in vitro assays to evaluate LBFs at the preclinical stage. In this study, the suitability of three different in vitro digestion assays for the evaluation of sLBFs was assessed; the classic one-step intestinal digestion assay, a two-step gastrointestinal digestion assay and a bicompartmental assay permitting the simultaneous monitoring of digestion and permeation of the active pharmaceutical ingredient (API) across an artificial membrane (Lecithin in Dodecane - LiDo). Three sLBFs (M1-M3) with varied composition and ritonavir as model drug were prepared and examined. When comparing the ability of these formulations to keep the drug solubilized in the aqueous phase, all three assays show that M1 performs better, while M3 presents poor performance. However, the classic in vitro intestinal digestion assay fails to provide a clear ranking of the three formulations, something that is more evident when using the two modified and more physiologically relevant assays. Also, the two modified assays provide additional information about the performance of the formulations including the performance in the gastric environment and intestinal flux of the drug. These modified in vitro digestion assays are valuable tools for the development and evaluation of sLBFs to make better informed decisions of which formulations to pursue for in vivo studies.
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| 47. |
- Andrés, E., et al.
(author)
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Status of the AMANDA experiment
- 1999
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In: Nuclear physics B, Proceedings supplements. - : Elsevier. - 0920-5632 .- 1873-3832. ; 70:1-3, s. 448-452
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Journal article (peer-reviewed)abstract
- The AMANDA high energy neutrino telescope has successfully been increased in size from four detector strings to ten detector strings during the 1996/1997 season. The first upward going muon-neutrino candidates have been reconstructed from the 1996 year's four-string data. Three new detector strings will be deployed during 1997/1998 to 2350 metres depth.
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| 48. |
- Andres, E., et al.
(author)
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The AMANDA neutrino telescope : Principle of operation and first results
- 2000
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In: Astroparticle physics. - : Elsevier. - 0927-6505 .- 1873-2852. ; 13:1, s. 1-20
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Journal article (peer-reviewed)abstract
- AMANDA is a high-energy neutrino telescope presently under construction at the geographical South Pole. In the Antarctic summer 1995/96, an array of 80 optical modules (OMs) arranged on 4 strings (AMANDA-B4) was deployed at depths between 1.5 and 2 km. In this paper we describe the design and performance of the AMANDA-B4 prototype, based on data collected between February and November 1996. Monte Carlo simulations of the detector response to down-going atmospheric muon tracks show that the global behavior of the detector is understood. We describe the data analysis method and present first results on atmospheric muon reconstruction and separation of neutrino candidates. The AMANDA array was upgraded with 216 OMs on 6 new strings in 1996/97 (AMANDA-B10), and 122 additional OMs on 3 strings in 1997/98.
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| 49. |
- Askebjer, P., et al.
(author)
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AMANDA : status report from the 1993-94 campaign and optical properties of the South Pole ice
- 1995
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In: Nuclear physics B, Proceedings supplements. - : Elsevier. - 0920-5632 .- 1873-3832. ; 38:1-3, s. 287-292
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Journal article (peer-reviewed)abstract
- We report the first results of the AMANDA detector. During the antarctic summer 1993-94 four strings were deployed between 0.8 an 1 km depth, each equipped with 20 photomultiplier tubes (PMTs). A laser source was used to investigate the optical properties of the ice in situ. We find that the ice is intrinsically extremely transparent. The measured absorption length is 59 ± 3 m, i.e. comparable with the quality of the ultra-pure water used in the IMB and Kamiokande proton-decay and neutrino experiments [1,2] and more than two times longer than the best value reported for laboratory ice [3]. Due to a residual density of air bubbles at these depths, the motion of photons in the medium is randomized. For spherical, smooth bubbles we find that, at 1 km depth, the average distance between collisions is about 25 cm. The measured inverse scattering length on bubbles decreases linearly with increasing depth in the volume of ice investigated. © 1995 Elsevier Science B.V. All rights reserved.
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| 50. |
- Askebjer, P., et al.
(author)
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Optical properties of deep ice at the South Pole : Absorption
- 1997
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In: Applied Optics. - : Optical Society of America. - 0003-6935 .- 1539-4522. ; 36:18, s. 4168-4180
-
Journal article (peer-reviewed)abstract
- We discuss recent measurements of the wavelength-dependent absorption coefficients in deep South Pole ice. The method uses transit-time distributions of pulses from a variable-frequency laser sent between emitters and receivers embedded in the ice. At depths of 800-1000 m scattering is dominated by residual air bubbles, whereas absorption occurs both in ice itself and in insoluble impurities. The absorption coefficient increases approximately exponentially with wavelength in the measured interval 410-610 nm. At the shortest wavelength our value is approximately a factor 20 below previous values obtained for laboratory ice and lake ice; with increasing wavelength the discrepancy with previous measurements decreases. At ∼415 to ∼500 nm the experimental uncertainties are small enough for us to resolve an extrinsic contribution to absorption in ice: submicrometer dust particles contribute by an amount that increases with depth and corresponds well with the expected increase seen near the Last Glacial Maximum in Vostok and Dome C ice cores. The laser pulse method allows remote mapping of gross structure in dust concentration as a function of depth in glacial ice.
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