| 1. |
- Kanai, M, et al.
(författare)
-
- 2023
-
swepub:Mat__t
|
|
| 2. |
- Niemi, MEK, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Dankiewicz, Josef, et al.
(författare)
-
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
- 2021
-
Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 384:24, s. 2283-2294
-
Tidskriftsartikel (refereegranskat)abstract
- Hypothermia or Normothermia after Cardiac Arrest This trial randomly assigned patients with coma after out-of-hospital cardiac arrest to undergo targeted hypothermia at 33 degrees C or normothermia with treatment of fever. At 6 months, there were no significant between-group differences regarding death or functional outcomes. Background Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. Methods In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33 degrees C, followed by controlled rewarming, or targeted normothermia with early treatment of fever (body temperature, >= 37.8 degrees C). The primary outcome was death from any cause at 6 months. Secondary outcomes included functional outcome at 6 months as assessed with the modified Rankin scale. Prespecified subgroups were defined according to sex, age, initial cardiac rhythm, time to return of spontaneous circulation, and presence or absence of shock on admission. Prespecified adverse events were pneumonia, sepsis, bleeding, arrhythmia resulting in hemodynamic compromise, and skin complications related to the temperature management device. Results A total of 1850 patients were evaluated for the primary outcome. At 6 months, 465 of 925 patients (50%) in the hypothermia group had died, as compared with 446 of 925 (48%) in the normothermia group (relative risk with hypothermia, 1.04; 95% confidence interval [CI], 0.94 to 1.14; P=0.37). Of the 1747 patients in whom the functional outcome was assessed, 488 of 881 (55%) in the hypothermia group had moderately severe disability or worse (modified Rankin scale score >= 4), as compared with 479 of 866 (55%) in the normothermia group (relative risk with hypothermia, 1.00; 95% CI, 0.92 to 1.09). Outcomes were consistent in the prespecified subgroups. Arrhythmia resulting in hemodynamic compromise was more common in the hypothermia group than in the normothermia group (24% vs. 17%, P<0.001). The incidence of other adverse events did not differ significantly between the two groups. Conclusions In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not lead to a lower incidence of death by 6 months than targeted normothermia. (Funded by the Swedish Research Council and others; TTM2 ClinicalTrials.gov number, .)
|
|
| 6. |
- Ständer, S., et al.
(författare)
-
EADV Task Force Pruritus White Paper on chronic pruritus and chronic prurigo : Current challenges and future solutions
- 2024
-
Ingår i: Journal of the European Academy of Dermatology and Venereology. - 0926-9959. ; 38:9, s. 1687-1693
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic pruritus (CP) is frequent in general medicine and the most common complaint in general dermatology. The prevalence of CP is expected to rise in the future due to the ageing population. The clinical presentation, underlying aetiology and treatment strategy of CP are heterogeneous. Also, individual treatment aims and physical, psychic and economic burdens of patients might vary. Chronic prurigo (CPG) is the most severe disease in the chronic pruritus spectrum, being associated with long-standing scratch-induced skin lesions and a therapy refractory itch-scratch-cycle. It is thus important to raise disease awareness for CP and CPG in the general public and among decision-makers in the health system. Further, there is a need to support a rational clinical framework to optimize both diagnostics and therapeutics. Currently, there is still a shortcoming regarding approved therapies and understanding CP/CPG as severe medical conditions. Therefore, the EADV Task Force Pruritus decided to publish this white paper based on several consensus meetings. The group consented on the following goals: (a) ensure that CP is recognized as a serious condition, (b) increase public awareness and understanding of CP and CPG as chronic and burdensome diseases that can greatly affect a person's quality of life, (c) clarify that in most cases CP and CPG are non-communicable and not caused by a psychiatric disease, (d) improve the support and treatment given to patients with CP to help them manage their disease and (e) publicize existing therapies including current guidelines. We aim to point to necessary improvements in access and quality of care directed to decision-makers in health policy, among payers and administrations as well as in practical care.
|
|
| 7. |
- Bourgoin, M., et al.
(författare)
-
Investigation of the small-scale statistics of turbulence in the Modane S1MA wind tunnel
- 2018
-
Ingår i: CEAS Aeronautical Journal. - : Springer. - 1869-5582 .- 1869-5590. ; 9:2, s. 269-281
-
Tidskriftsartikel (refereegranskat)abstract
- This article describes the planning, set-up, turbulence characterization and analysis of measurements of a passive grid turbulence experiment that was carried out in the S1MA wind-tunnel from ONERA in Modane, in the context of the ESWIRP European project. This experiment aims at a detailed investigation of the statistical properties of turbulent flows at large Reynolds numbers. The primary goal is to take advantage of the unequaled large-scale dimensions of the ONERA S1MA wind-tunnel facility, to make available to the broad turbulence community high-quality experimental turbulence data with unprecendented resolution (both spatial and temporal) and accuracy (in terms of statistical convergence). With this goal, we designed the largest grid-generated turbulence experiment planned and performed to date. Grid turbulence is a canonical flow known to produce almost perfectly homogeneous and isotropic turbulence (HIT) which remains a unique framework to investigate fundamental physics of turbulent flows. Here, we present a brief description of the measurements, in particular those based on hot-wire diagnosis. By comparing results from classical hot-wires and from a nano-fabricated wire (developed at Princeton University), we show that our goal of resolving down to the smallest dissipative scales of the flow has been achieved. We also present the full characterization of the turbulence here, in terms of turbulent energy dissipation rate, injection and dissipation scales (both spatial and temporal) and Reynolds number.
|
|
| 8. |
|
|
| 9. |
- Hoepffner, Jérôme, et al.
(författare)
-
Linear feedback control of transition in shear flows
- 2006
-
Ingår i: Sixth IUTAM Symposium on Laminar-Turbulent Transition. - DORDRECHT : SPRINGER. - 1402034598 ; , s. 213-218
-
Konferensbidrag (refereegranskat)abstract
- This work focuses on the application of linear feedback control to transition to turbulence in shear flows. The controller uses wall-mounted sensor information to estimate the flow disturbances and uses wall actuators to prevent transition to turbulence. The flow disturbances are induced by external sources of perturbations described by means of a stochastic volume forcing. We show that improved performance can be achieved if the proper destabilisation mechanisms are targeted.
|
|
| 10. |
- Hoepffner, Jeróme, et al.
(författare)
-
State estimation in wall-bounded flow systems : P. I Laminar flows
- 2005
-
Ingår i: Journal of fluid mechanics. - 0022-1120. ; 534, s. 263-394
-
Tidskriftsartikel (refereegranskat)abstract
- In applications involving the model-based control of transitional wall-bounded flow systems, it is often desired to estimate the interior flow state based on a history of noisy measurements from an array of flush-mounted skin-friction and pressure sensors on the wall. This paper considers this estimation problem, using a Kalman filter based on the linearized Navier-Stokes equations and appropriate stochastic models for the relevant statistics of the initial conditions, sensor noise and external disturbances acting on the system. We show that a physically relevant parameterization of these statistics is key to obtaining well-resolved feedback kernels with appropriate spatial extent for all three types of flow measurement available on the wall. The effectiveness of the resulting Kalman and extended Kalman filters that implement this feedback is verified for both infinitesimal and finite-amplitude disturbances in direct numerical simulations of a perturbed laminar channel flow. The consideration of time-varying feedback kernels is shown to be particularly advantageous in accelerating the convergencc of the estimator from unknown initial conditions. A companion paper (Part 2) considers the extension of such estimators to the case of fully developed turbulence.
|
|
| 11. |
- Hogberg, M., et al.
(författare)
-
Linear feedback control and estimation of transition in plane channel flow
- 2003
-
Ingår i: Journal of Fluid Mechanics. - : Cambridge University Press (CUP). - 0022-1120 .- 1469-7645. ; 481, s. 149-175
-
Tidskriftsartikel (refereegranskat)abstract
- Modern linear control theory has recently been established as a viable tool for developing effective, spatially localized convolution kernels for the feedback control and estimation of linearized Navier-Stokes systems. In the present paper, the effectiveness of these kernels for significantly expanding the basin of attraction of the laminar state in a subcritical nonlinear channel flow system is quantified using direct numerical simulations for a range of Reynolds numbers (Re-q = 2000, 3000 and 5000) and for a variety of initial conditions of physical interest. This is done by quantifying the change in the transition thresholds (see Reddy et al. 1998) when feedback control is applied. Such transition thresholds provide a relevant measure of performance for transition control strategies even in the nonlinear regime. Initial flow perturbations with streamwise vortices, oblique waves, and random excitations over an array of several Fourier modes are considered. It is shown that the minimum amplitude of these initial flow perturbations that is sufficient to excite nonlinear instability, and thereby promote transition to turbulence, is significantly increased by application of the control feedback. The kernels used to apply the feedback are found to decay exponentially with distance far from the origin, as predicted by the analysis of Bamieh, Paganini & Dahleh (2002). In the present paper, it is demonstrated via numerical simulation that truncation of these spatially localized convolution kernels to spatially compact kernels with finite non-zero support does not significantly degrade the effectiveness of the control feedback. In addition to the new state-feedback control results, exponential convergence of a localized physical-space state estimator with wall measurements is also demonstrated. The estimator and the full-state feedback controller are then combined to obtain a wall-information-based linear compensator. The compensator performance is also quantified, and key issues related to improving the performance of this compensator, which is degraded compared with the full-state feedback controller, are discussed.
|
|
| 12. |
- Hogberg, M., et al.
(författare)
-
Relaminarization of Re-tau=100 turbulence using gain scheduling and linear state-feedback control
- 2003
-
Ingår i: Physics of fluids. - : AIP Publishing. - 1070-6631 .- 1089-7666. ; 15:11, s. 3572-3575
-
Tidskriftsartikel (refereegranskat)abstract
- The first successful application of linear full-state feedback optimal control theory to consistently relaminarize turbulent channel flow at Re-tau=100 with full state information and gain scheduling is reported. The actuation is zero-net mass-flux blowing and suction on the channel walls. Two key issues central to the success of this strategy are: (a) the choice of the mean-flow profile about which the equations are linearized for the computation of the linear feedback gains, and (b) the choice of an objective function which targets the control effort on the flow perturbations of interest. A range of mean-flow profiles between the laminar and fully turbulent profiles and a weighted energy measure which targets flow perturbations in the near-wall region were found to provide effective feedback gains. A gain-scheduling strategy to tune the feedback gains to the nonstationary mean-flow profile is introduced, resulting in consistent relaminarization of the turbulent flow in all realizations tested.
|
|
| 13. |
- Jacobsen, Henrik, et al.
(författare)
-
Spin dynamics of the director state in frustrated hyperkagome systems
- 2021
-
Ingår i: Physical Review B. - : American Physical Society. - 2469-9969 .- 2469-9950. ; 104:5
-
Tidskriftsartikel (refereegranskat)abstract
- We present an experimental study of the magnetic structure and dynamics of two frustrated hyperkagome compounds, Gd3Ga5O12 and Gd3Al5O12. It has previously been shown that Gd3Ga5O12 exhibits long-range correlations of multipolar directors that are formed from antiferromagnetic spins on loops of ten ions. Using neutron diffraction and reverse Monte Carlo simulations we prove the existence of similar magnetic correlations in Gd3Al5O12, showing the ubiquity of these complex structures in frustrated hyperkagome materials. Using inelastic neutron scattering we shed further light on the director state and the associated low-lying magnetic excitations. In addition, we have measured quasielastic dynamics that show evidence of spin diffusion. Finally, we present AC susceptibility measurements on both Gd3Ga5O12 and Gd3Al5O12, revealing a large difference in the low-frequency dynamics between the two otherwise similar compounds.
|
|
| 14. |
- Thyssen, Jacob P., et al.
(författare)
-
Effect of abrocitinib vs. dupilumab on skin pain : an analysis of the phase 3 JADE COMPARE and JADE DARE trials
- 2023
-
Ingår i: British Journal of Dermatology. - : Oxford University Press. - 0007-0963 .- 1365-2133. ; 188:Suppl. 3
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Skin pain is a common and bothersome symptom of atopic dermatitis (AD) that is associated with a substantial burden. To assess the efficacy of abrocitinib vs. dupilumab on skin pain in patients with moderate-to-severe AD. Data from patients aged ≥18 years who received oral abrocitinib 200 mg once daily (QD) or subcutaneous dupilumab 300 mg once every 2 weeks in combination with topical therapy in the phase 3 trials JADE COMPARE (NCT03720470) and JADE DARE (NCT04345367) were analysed. Data from patients who received abrocitinib 100 mg QD or placebo in the JADE COMPARE trial were also included in this analysis. Patients rated their skin pain using the Skin Pain Numerical Rating Scale (NRS) item of the Pruritus and Symptoms Assessment for Atopic Dermatitis (PSAAD) instrument [‘How painful was your skin over the past 24 h?’ on a scale from 0 (not painful) to 10 (extremely painful) ] in JADE COMPARE or the Skin Pain Numerical Rating Scale [SP-NRS, which queried patients for the severity of their ‘worst skin pain’ in the past 24 h on a scale from 0 (no skin pain) to 10 (worst skin pain imaginable)] in JADE DARE. Least squares mean (LSM) changes from baseline and proportions of patients who achieved a ≥4-point improvement from baseline in PSAAD skin pain score or SP-NRS were assessed through Week 16 (JADE COMPARE) or Week 26 (JADE DARE). The JADE COMPARE analysis (Skin Pain NRS item of the PSAAD) was performed post hoc, whereas the JADE DARE analysis (SP-NRS) was prespecified. At Week 2 of JADE COMPARE, LSM change from baseline in PSAAD skin pain score was greater with abrocitinib 200 mg [−2.8 (95% CI, −3.1, −2.5)] than with abrocitinib 100 mg [−2.1 (−2.3, −1.8)], dupilumab [−2.0 (−2.3, −1.8)], or placebo [−1.3 (−1.6, −0,9)]; improvements were sustained through Week 16 of treatment with abrocitinib 200 mg [−4.1 (−4.4, −3.8)], abrocitinib 100 mg [−3.3 (−3.6, −3.0)] and dupilumab [−4.0 (−4.2, −3.7)] compared with placebo [−1.8 (−2.2, −1.4)]. In JADE DARE, LSM change from baseline in SP-NRS was significantly greater with abrocitinib 200 mg vs. dupilumab at Week 2 [−3.7 (−3.9, −3.4) vs. −2.6 (−2.8, −2.3); P < 0.0001] and week 12 [−4.5 (−4.7, −4.2) vs. −4.0 (−4.3, −3.8); P = 0.0116]; no significant differences were observed between the treatment arms at Week 16 [−4.4 (−4.7, −4.2) vs. −4.2 (−4.4, −4.0); P = 0.16], Week 20 [−4.8 (−5.0, −4.5) vs. −4.5 (−4.7 vs. −4.2); P = 0.06] or Week 26 [−4.5 (−4.8, −4.3)] vs. −4.3 (−4.6, −4.1); P = 0.27]. The proportions of patients who achieved a ≥4-point improvement in PSAAD skin pain score at week 2 of JADE COMPARE were greater with abrocitinib 200 mg (43%) than with abrocitinib 100 mg (23%), dupilumab (24%) or placebo (14%). At Week 16, these proportions increased to 76% (abrocitinib 200 mg), 57% (abrocitinib 100 mg) and 70% (dupilumab) compared with placebo (29%). In JADE DARE, the proportions of patients who achieved a ≥4-point improvement in SP-NRS were significantly greater with abrocitinib 200 mg vs. dupilumab at Week 2 (58% vs. 36%; P < 0.0001) and Week 12 (71% vs. 61%; P = 0.0098) but not at subsequent timepoints. Similar to previous findings on the effect of abrocitinib on itch, these results suggest that abrocitinib 200 mg provides greater early skin pain relief in patients with moderate-to-severe AD compared with dupilumab, but the difference between the treatments diminishes with time. At earlier time points, skin pain improvement with abrocitinib 100 mg was similar to that with dupilumab.
|
|
