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- Bettegowda, Chetan, et al.
(författare)
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Detection of circulating tumor DNA in early- and late-stage human malignancies
- 2014
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 6:224, s. 224ra24-
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Tidskriftsartikel (refereegranskat)abstract
- The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain reaction-based technologies to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types. We found that ctDNA was detectable in >75% of patients with advanced pancreatic, ovarian, colorectal, bladder, gastroesophageal, breast, melanoma, hepatocellular, and head and neck cancers, but in less than 50% of primary brain, renal, prostate, or thyroid cancers. In patients with localized tumors, ctDNA was detected in 73, 57, 48, and 50% of patients with colorectal cancer, gastroesophageal cancer, pancreatic cancer, and breast adenocarcinoma, respectively. ctDNA was often present in patients without detectable circulating tumor cells, suggesting that these two biomarkers are distinct entities. In a separate panel of 206 patients with metastatic colorectal cancers, we showed that the sensitivity of ctDNA for detection of clinically relevant KRAS gene mutations was 87.2% and its specificity was 99.2%. Finally, we assessed whether ctDNA could provide clues into the mechanisms underlying resistance to epidermal growth factor receptor blockade in 24 patients who objectively responded to therapy but subsequently relapsed. Twenty-three (96%) of these patients developed one or more mutations in genes involved in the mitogen-activated protein kinase pathway. Together, these data suggest that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes in patients with multiple different types of cancer.
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| 3. |
- Olugbade, Temitayo, et al.
(författare)
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Human Movement Datasets : An Interdisciplinary Scoping Review
- 2023
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Ingår i: ACM Computing Surveys. - : Association for Computing Machinery (ACM). - 0360-0300 .- 1557-7341. ; 55:6
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Forskningsöversikt (refereegranskat)abstract
- Movement dataset reviews exist but are limited in coverage, both in terms of size and research discipline. While topic-specific reviews clearly have their merit, it is critical to have a comprehensive overview based on a systematic survey across disciplines. This enables higher visibility of datasets available to the research communities and can foster interdisciplinary collaborations. We present a catalogue of 704 open datasets described by 10 variables that can be valuable to researchers searching for secondary data: name and reference, creation purpose, data type, annotations, source, population groups, ordinal size of people captured simultaneously, URL, motion capture sensor, and funders. The catalogue is available in the supplementary materials. We provide an analysis of the datasets and further review them under the themes of human diversity, ecological validity, and data recorded. The resulting 12-dimension framework can guide researchers in planning the creation of open movement datasets. This work has been the interdisciplinary effort of researchers across affective computing, clinical psychology, disability innovation, ethnomusicology, human-computer interaction, machine learning, music cognition, music computing, and movement neuroscience.
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| 4. |
- Stigliani, Ileana, et al.
(författare)
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Framing the multifaceted nature of design thinking in addressing different innovation purposes
- 2022
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Ingår i: Long Range Planning. - : Elsevier. - 1873-1872 .- 0024-6301. ; 55:5
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Tidskriftsartikel (refereegranskat)abstract
- Scholars and practitioners acknowledge the role of design, and specifically design thinking, as a driver of innovation and change. Design thinking is gaining attention in the business community beyond the traditional product innovation realm and is increasingly promoted as an engine for the creation of novel user experiences, new businesses, strategic transformation, organizational and cultural change. Is it reasonable to assume that the same set of practices fits such a broad range of applications equally well? This study addresses how design thinking applications are differently framed when addressing diverse innovation purposes. Specifically, we compare two purposes: innovation of solutions, encompassing traditional product and service development projects, and innovation of direction, encompassing strategic and organizational renewal projects. Based on data collected from 146 design thinking projects conducted by European consulting firms we investigate the relationships between the design thinking practices adopted and the value generated by the projects. We then analyze how these relationships vary depending on the purpose of the innovation project, namely whether focused on innovating solutions or direction. The results show that different purposes indeed call for different practices. In projects aimed at innovating solutions, market value is positively related to capturing current user needs and envisioning future society. Conversely, in projects aimed at innovating direction, market value is positively related to challenging current assumptions. © 2021 Elsevier Ltd
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