↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Biller B.) "

Sökning: WFRF:(Biller B.)

Resultat 1-50 av 51

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Nogueira, RG, et al. (författare) Global Impact of COVID-19 on Stroke Care and IV Thrombolysis 2021 Ingår i: Neurology. - 1526-632X. ; 96:23, s. E2824-E2838 Tidskriftsartikel (refereegranskat)
2.	Bonnefoy, M., et al. (författare) The GJ 504 system revisited Combining interferometric, radial velocity, and high contrast imaging data 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 618 Tidskriftsartikel (refereegranskat)abstract Context. The G-type star GJ504A is known to host a 3-35 M-Jup companion whose temperature, mass, and projected separation all contribute to making it a test case for planet formation theories and atmospheric models of giant planets and light brown dwarfs. Aims. We aim at revisiting the system age, architecture, and companion physical and chemical properties using new complementary interferometric, radial-velocity, and high-contrast imaging data. Methods. We used the CHARA interferometer to measure GJ504A's angular diameter and obtained an estimation of its radius in combination with the HIPPARCOS parallax. The radius was compared to evolutionary tracks to infer a new independent age range for the system. We collected dual imaging data with IRDIS on VLT/SPHERE to sample the near-infrared (1.02-2.25 mu m) spectral energy distribution (SED) of the companion. The SED was compared to five independent grids of atmospheric models (petitCODE, Exo-REM, BT-SETTL, Morley et al., and ATMO) to infer the atmospheric parameters of GJ 504b and evaluate model-to-model systematic errors. In addition, we used a specific model grid exploring the effect of different C/O ratios. Contrast limits from 2011 to 2017 were combined with radial velocity data of the host star through the MESS2 tool to define upper limits on the mass of additional companions in the system from 0.01 to 100 au. We used an MCMC fitting tool to constrain the companion's orbital parameters based on the measured astrometry, and dedicated formation models to investigate its origin. Results. We report a radius of 1.35 +/- 0.04 R-circle dot for GJ504A. The radius yields isochronal ages of 21 +/- 2 Myr or 4.0 +/- 1.8 Gyr for the system and line-of-sight stellar rotation axis inclination of 162.4(-4.3)(+3.8) degrees or 18.6(-3.8)(+4.3) degrees. We re-detect the companion in the Y2, Y3, J3, H2, and K1 dual-band images. The complete 1-4 mu m SED shape of GJ504b is best reproduced by T8-T9.5 objects with intermediate ages (<= 1.5Gyr), and/or unusual dusty atmospheres and/or super-solar metallicities. All atmospheric models yield T-eff = 550 +/- 50 K for GJ504b and point toward a low surface gravity (3.5-4.0 dex). The accuracy on the metallicity value is limited by model-to-model systematics; it is not degenerate with the C/O ratio. We derive log L/L-circle dot = 6.15 +/- 0.15 dex for the companion from the empirical analysis and spectral synthesis. The luminosity and T-eff yield masses of M = 1.3(-0.3)(+0.6) M-Jup and M = 23(-9)(+10) M-Jup for the young and old age ranges, respectively. The semi-major axis (sma) is above 27.8 au and the eccentricity is lower than 0.55. The posterior on GJ 504b's orbital inclination suggests a misalignment with the rotation axis of GJ 504A. We exclude additional objects (90% prob.) more massive than 2.5 and 30 M-Jup with semi-major axes in the range 0.01-80 au for the young and old isochronal ages, respectively. Conclusions. The mass and semi-major axis of GJ 504b are marginally compatible with a formation by disk-instability if the system is 4 Gyr old. The companion is in the envelope of the population of planets synthesized with our core-accretion model. Additional deep imaging and spectroscopic data with SPHERE and JWST should help to confirm the possible spin-orbit misalignment and refine the estimates on the companion temperature, luminosity, and atmospheric composition.
3.	Chauvin, G., et al. (författare) Discovery of a warm, dusty giant planet around HIP 65426 2017 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 605 Tidskriftsartikel (refereegranskat)abstract Aims. The SHINE program is a high-contrast near-infrared survey of 600 young, nearby stars aimed at searching for and characterizing new planetary systems using VLT/SPHERE's unprecedented high-contrast and high-angular-resolution imaging capabilities. It is also intended to place statistical constraints on the rate, mass and orbital distributions of the giant planet population at large orbits as a function of the stellar host mass and age to test planet-formation theories.Methods. We used the IRDIS dual-band imager and the IFS integral field spectrograph of SPHERE to acquire high-contrast coronagraphic differential near-infrared images and spectra of the young A2 star HIP 65426. It is a member of the similar to 17 Myr old Lower Centaurus-Crux association. Results. At a separation of 830 mas (92 au projected) from the star, we detect a faint red companion. Multi-epoch observations confirm that it shares common proper motion with HIP 65426. Spectro-photometric measurements extracted with IFS and IRDIS between 0.95 and 2.2 mu m indicate a warm, dusty atmosphere characteristic of young low-surface-gravity L5-L7 dwarfs. Hot-start evolutionary models predict a luminosity consistent with a 6-12 M-Jup, T-eff = 1300-1600K and R = 1.5 +/- 0.1 R-Jup giant planet. Finally, the comparison with Exo-REM and PHOENIX BT-Settl synthetic atmosphere models gives consistent effective temperatures but with slightly higher surface gravity solutions of log(g) = 4.0-5.0 with smaller radii (1.0-1.3 R-Jup).Conclusions. Given its physical and spectral properties, HIP 65426 b occupies a rather unique placement in terms of age, mass, and spectral-type among the currently known imaged planets. It represents a particularly interesting case to study the presence of clouds as a function of particle size, composition, and location in the atmosphere, to search for signatures of non-equilibrium chemistry, and finally to test the theory of planet formation and evolution.
4.	Allen, D. B., et al. (författare) GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults 2016 Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 174:2 Tidskriftsartikel (refereegranskat)abstract Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that 'for approved indications, GH is safe'; however, the statement highlighted a number of areas for on-going surveillance of long-term safety, including cancer risk, impact on glucose homeostasis, and use of high dose pharmacological rhGH treatment. Over the intervening years, there have been a number of publications addressing the safety of rhGH with regard to mortality, cancer and cardiovascular risk, and the need for long-term surveillance of the increasing number of adults who were treated with rhGH in childhood. Against this backdrop of interest in safety, the European Society of Paediatric Endocrinology (ESPE), the GRS, and the Pediatric Endocrine Society (PES) convened a meeting to reappraise the safety of rhGH. The ouput of the meeting is a concise position statement.
5.	Cheetham, A., et al. (författare) Discovery of a brown dwarf companion to the star HIP 64892 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 615 Tidskriftsartikel (refereegranskat)abstract We report the discovery of a bright, brown dwarf companion to the star HIP 64892, imaged with VLT/SPHERE during the SHINE exoplanet survey. The host is a B9.5V member of the Lower-Centaurus-Crux subgroup of the Scorpius Centaurus OB association. The measured angular separation of the companion (1.2705 +/- 0.0023) corresponds to a projected distance of 159 +/- 12AU. We observed the target with the dual-band imaging and long-slit spectroscopy modes of the IRDIS imager to obtain its spectral energy distribution (SED) and astrometry. In addition, we reprocessed archival NACO L-band data, from which we also recover the companion. Its SED is consistent with a young (<30 Myr), low surface gravity object with a spectral type of M9 gamma +/- 1. From comparison with the BT-Settl atmospheric models we estimate an effective temperature of T-eff = 2600 +/- 100 K, and comparison of the companion photometry to the COND evolutionary models yields a mass of similar to 29-37 M-J at the estimated age of 16(-7)(+15) Myr for the system. The star HIP 64892 is a rare example of an extreme-mass ratio system (q similar to 0.01) and will be useful for testing models relating to the formation and evolution of such low-mass objects.
6.	Christiansen, J. S., et al. (författare) Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations 2016 Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 174:6 Tidskriftsartikel (refereegranskat)abstract Objective: The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH). Participants: A closed meeting of 55 international scientists with expertise in GH, including pediatric and adult endocrinologists, basic scientists, regulatory scientists, and participants from the pharmaceutical industry. Evidence: Current literature was reviewed for gaps in knowledge. Expert opinion was used to suggest studies required to address potential safety and efficacy issues. Consensus process: Following plenary presentations summarizing the literature, breakout groups discussed questions framed by the planning committee. Attendees reconvened after each breakout session to share group reports. A writing team compiled the breakout session reports into a draft document that was discussed and revised in an open forum on the concluding day. This was edited further and then circulated to attendees from academic institutions for review after the meeting. Participants from pharmaceutical companies did not participate in the planning, writing, or in the discussions and text revision on the final day of the workshop. Scientists from industry and regulatory agencies reviewed the manuscript to identify any factual errors. Conclusions: LAGH compounds may represent an advance over daily GH injections because of increased convenience and differing phamacodynamic properties, providing the potential for improved adherence and outcomes. Better methods to assess adherence must be developed and validated. Long-term surveillance registries that include assessment of efficacy, cost-benefit, disease burden, quality of life, and safety are essential for understanding the impact of sustained exposure to LAGH preparations.
7.	Defrere, D., et al. (författare) Space-based infrared interferometry to study exoplanetary atmospheres 2018 Ingår i: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 46:3, s. 543-560 Tidskriftsartikel (refereegranskat)abstract The quest for other habitable worlds and the search for life among them are major goals of modern astronomy. One way to make progress towards these goals is to obtain high-quality spectra of a large number of exoplanets over a broad range of wavelengths. While concepts currently investigated in the United States are focused on visible/NIR wavelengths, where the planets are probed in reflected light, a compelling alternative to characterize planetary atmospheres is the mid-infrared waveband (5–20 μm). Indeed, mid-infrared observations provide key information on the presence of an atmosphere, the surface conditions (e.g., temperature, pressure, habitability), and the atmospheric composition in important species such as H2O, CO2, O3, CH4, and N2O. This information is essential to investigate the potential habitability of exoplanets and to make progress towards the search for life in the Universe. Obtaining high-quality mid-infrared spectra of exoplanets from the ground is however extremely challenging due to the overwhelming brightness and turbulence of the Earth’s atmosphere. In this paper, we present a concept of space-based mid-infrared interferometer that can tackle this observing challenge and discuss the main technological developments required to launch such a sophisticated instrument.
8.	Desidera, S., et al. (författare) The SPHERE infrared survey for exoplanets (SHINE) I. Sample definition and target characterization 2021 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 651 Tidskriftsartikel (refereegranskat)abstract Context. Large surveys with new-generation high-contrast imaging instruments are needed to derive the frequency and properties of exoplanet populations with separations from ~5 to 300 au. A careful assessment of the stellar properties is crucial for a proper understanding of when, where, and how frequently planets form, and how they evolve. The sensitivity of detection limits to stellar age makes this a key parameter for direct imaging surveys.Aims. We describe the SpHere INfrared survey for Exoplanets (SHINE), the largest direct imaging planet-search campaign initiated at the VLT in 2015 in the context of the SPHERE Guaranteed Time Observations of the SPHERE consortium. In this first paper we present the selection and the properties of the complete sample of stars surveyed with SHINE, focusing on the targets observed during the first phase of the survey (from February 2015 to February 2017). This early sample composed of 150 stars is used to perform a preliminary statistical analysis of the SHINE data, deferred to two companion papers presenting the survey performance, main discoveries, and the preliminary statistical constraints set by SHINE.Methods. Based on a large database collecting the stellar properties of all young nearby stars in the solar vicinity (including kinematics, membership to moving groups, isochrones, lithium abundance, rotation, and activity), we selected the original sample of 800 stars that were ranked in order of priority according to their sensitivity for planet detection in direct imaging with SPHERE. The properties of the stars that are part of the early statistical sample wererevisited, including for instance measurements from the Gaia Data Release 2. Rotation periods were derived for the vast majority of the late-type objects exploiting TESS light curves and dedicated photometric observations.Results. The properties of individual targets and of the sample as a whole are presented.
9.	Dupuy, T. J., et al. (författare) Multiplicity of cool dwarfs 2013 Ingår i: Astronomical Notes - Astronomische Nachrichten. - : Wiley. - 0004-6337 .- 1521-3994. ; 334:1-2, s. 36-39 Tidskriftsartikel (refereegranskat)abstract Multiple systems have long been used to probe the origin and evolution of stars of all masses. Only in the past 10-15 years have such studies been extended to brown dwarfs and the lowest mass stars through binary surveys of both young star forming regions and the older field population. In addition, a groundswell of interest in M dwarfs in recent years has resulted in large, modern datasets for these most common stars in the Galaxy, thereby enabling renewed perspectives on their multiplicity properties. These latest observational results have in turn fueled the many theories competing to explain the formation of low-mass stars and brown dwarfs. This Cool Stars 17 splinter session examined the current state of this field by reviewing results from the numerous observational techniques - radial velocities, astrometry, direct imaging, and synoptic surveys - that have been used to study multiplicity from the earliest embedded protostars to objects in young star forming regions, old and intermediate-age clusters, as well as the more heterogeneous field population.
10.	Gratton, R., et al. (författare) Investigating three Sirius-like systems with SPHERE 2021 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 646 Tidskriftsartikel (refereegranskat)abstract Context. Sirius-like systems are relatively wide binaries with a separation from a few to hundreds of au; they are composed of a white dwarf (WD) and a companion of a spectral type earlier than M0. Here we consider main sequence (MS) companions, where the WD progenitor evolves in isolation, but its wind during the former asymptotic giant branch (AGB) phase pollutes the companion surface and transfers some angular momentum. They are rich laboratories to constrain stellar models and binary evolution.Aims. Within the SpHere INfrared survey for Exoplanet survey that uses the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument at the Very Large Telescope, our goal is to acquire high contrast multi-epoch observations of three Sirius-like systems, HD 2133, HD 114174, and CD-56 7708 and to combine this data with archive high resolution spectra of the primaries, TESS archive, and literature data.Methods. These WDs are easy targets for SPHERE and were used as spectrophotometric standards. We performed very accurate abundance analyses for the MS stars using methods considered for solar analogs. Whenever possible, WD parameters and orbits were obtained using Monte Carlo Markov chain methods.Results. We found brighter J and K magnitudes for HD 114174B than obtained previously and extended the photometry down to 0.95 μm. Our new data indicate a higher temperature and then shorter cooling age (5.57 ± 0.02 Gyr) and larger mass (0.75 ± 0.03 M⊙) for this WD than previously assumed. Together with the oldest age for the MS star connected to the use of the Gaia DR2 distance, this solved the discrepancy previously found with the age of the MS star. The two other WDs are less massive, indicating progenitors of ∼1.3 M⊙ and 1.5 − 1.8 M⊙ for HD 2133B and CD-56 7708B, respectively. In spite of the rather long periods, we were able to derive useful constraints on the orbit for HD 114174 and CD-56 7708. They are both seen close to edge-on, which is in agreement with the inclination of the MS stars that are obtained coupling the rotational periods, stellar radii, and the projected rotational velocity from spectroscopy. The composition of the MS stars agrees fairly well with expectations from pollution by the AGB progenitors of the WDs: HD 2133A has a small enrichment of n-capture elements, which is as expected for pollution by an AGB star with an initial mass < 1.5 M⊙; CD-56 7708A is a previously unrecognized mild Ba-star, which is also expected due to pollution by an AGB star with an initial mass in the range of 1.5 − 3.0 M⊙; and HD 114174 has a very moderate excess of n-capture elements, which is in agreement with the expectation for a massive AGB star to have an initial mass > 3.0 M⊙.Conclusions. On the other hand, none of these stars show the excesses of C that are expected to go along with those of n-capture elements. This might be related to the fact that these stars are at the edges of the mass range where we expect nucleosynthesis related to thermal pulses. More work, both theoretical and observational, is required to better understand this issue.
11.	Lagrange, A. -M., et al. (författare) Post-conjunction detection of beta Pictoris b with VLT/SPHERE 2019 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 621 Tidskriftsartikel (refereegranskat)abstract Context. With an orbital distance comparable to that of Saturn in the solar system, beta Pictoris b is the closest (semi-major axis similar or equal to 9 au) exoplanet that has been imaged to orbit a star. Thus it offers unique opportunities for detailed studies of its orbital, physical, and atmospheric properties, and of disk-planet interactions. With the exception of the discovery observations in 2003 with NaCo at the Very Large Telescope (VLT), all following astrometric measurements relative to beta Pictoris have been obtained in the southwestern part of the orbit, which severely limits the determination of the planet's orbital parameters.Aims. We aimed at further constraining beta Pictoris b orbital properties using more data, and, in particular, data taken in the northeastern part of the orbit.Methods. We used SPHERE at the VLT to precisely monitor the orbital motion of beta beta Pictoris b since first light of the instrument in 2014.Results. We were able to monitor the planet until November 2016, when its angular separation became too small (125 mas, i.e., 1.6 au) and prevented further detection. We redetected beta Pictoris b on the northeast side of the disk at a separation of 139 mas and a PA of 30 degrees in September 2018. The planetary orbit is now well constrained. With a semi-major axis (sma) of a = 9.0 +/- 0.5 au (1 sigma), it definitely excludes previously reported possible long orbital periods, and excludes beta Pictoris b as the origin of photometric variations that took place in 1981. We also refine the eccentricity and inclination of the planet. From an instrumental point of view, these data demonstrate that it is possible to detect, if they exist, young massive Jupiters that orbit at less than 2 au from a star that is 20 pc away.
12.	Langlois, M., et al. (författare) The SPHERE infrared survey for exoplanets (SHINE) : II. Observations, data reduction and analysis, detection performances, and initial results 2021 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 651 Tidskriftsartikel (refereegranskat)abstract Context. In recent decades, direct imaging has confirmed the existence of substellar companions (exoplanets or brown dwarfs) on wide orbits (>10 au) around their host stars. In striving to understand their formation and evolution mechanisms, in 2015 we initiated the SPHERE infrared survey for exoplanets (SHINE), a systematic direct imaging survey of young, nearby stars that is targeted at exploring their demographics.Aims. We aim to detect and characterize the population of giant planets and brown dwarfs beyond the snow line around young, nearby stars. Combined with the survey completeness, our observations offer the opportunity to constrain the statistical properties (occurrence, mass and orbital distributions, dependency on the stellar mass) of these young giant planets.Methods. In this study, we present the observing and data analysis strategy, the ranking process of the detected candidates, and the survey performances for a subsample of 150 stars that are representative of the full SHINE sample. Observations were conducted in a homogeneous way between February 2015 and February 2017 with the dedicated ground-based VLT/SPHERE instrument equipped with the IFS integral field spectrograph and the IRDIS dual-band imager, covering a spectral range between 0.9 and 2.3 μm. We used coronographic, angular, and spectral differential imaging techniques to achieve the best detection performances for this study, down to the planetary mass regime.Results. We processed, in a uniform manner, more than 300 SHINE observations and datasets to assess the survey typical sensitivity as a function of the host star and of the observing conditions. The median detection performance reached 5σ-contrasts of 13 mag at 200 mas and 14.2 mag at 800 mas with the IFS (YJ and YJH bands), and of 11.8 mag at 200 mas, 13.1 mag at 800 mas, and 15.8 mag at 3 as with IRDIS in H band, delivering one of the deepest sensitivity surveys thus far for young, nearby stars. A total of sixteen substellar companions were imaged in this first part of SHINE: seven brown dwarf companions and ten planetary-mass companions.These include two new discoveries, HIP 65426 b and HIP 64892 B, but not the planets around PDS70 that had not been originally selected for the SHINE core sample. A total of 1483 candidates were detected, mainly in the large field of view that characterizes IRDIS. The color-magnitude diagrams, low-resolution spectrum (when available with IFS), and follow-up observations enabled us to identify the nature (background contaminant or comoving companion) of about 86% of our subsample. The remaining cases are often connected to crowded-field follow-up observations that were missing. Finally, even though SHINE was not initially designed for disk searches, we imaged twelve circumstellar disks, including three new detections around the HIP 73145, HIP 86598, and HD 106906 systems.Conclusions. Nowadays, direct imaging provides a unique opportunity to probe the outer part of exoplanetary systems beyond 10 au to explore planetary architectures, as highlighted by the discoveries of: one new exoplanet, one new brown dwarf companion, and three new debris disks during this early phase of SHINE. It also offers the opportunity to explore and revisit the physical and orbital properties of these young, giant planets and brown dwarf companions (relative position, photometry, and low-resolution spectrum in near-infrared, predicted masses, and contrast in order to search for additional companions). Finally, these results highlight the importance of finalizing the SHINE systematic observation of about 500 young, nearby stars for a full exploration of their outer part to explore the demographics of young giant planets beyond 10 au and to identify the most interesting systems for the next generation of high-contrast imagers on very large and extremely large telescopes.
13.	Lazzoni, C., et al. (författare) Dynamical models to explain observations with SPHERE in planetary systems with double debris belts 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 611 Tidskriftsartikel (refereegranskat)abstract Context. A large number of systems harboring a debris disk show evidence for a double belt architecture. One hypothesis for explaining the gap between the debris belts in these disks is the presence of one or more planets dynamically carving it. For this reason these disks represent prime targets for searching planets using direct imaging instruments, like the Spectro-Polarimetric High-constrast Exoplanet Research (SPHERE) at the Very Large Telescope. Aims. The goal of this work is to investigate this scenario in systems harboring debris disks divided into two components, placed, respectively, in the inner and outer parts of the system. All the targets in the sample were observed with the SPHERE instrument, which performs high-contrast direct imaging, during the SHINE guaranteed time observations. Positions of the inner and outer belts were estimated by spectral energy distribution fitting of the infrared excesses or, when available, from resolved images of the disk. Very few planets have been observed so far in debris disks gaps and we intended to test if such non-detections depend on the observational limits of the present instruments. This aim is achieved by deriving theoretical predictions of masses, eccentricities, and semi-major axes of planets able to open the observed gaps and comparing such parameters with detection limits obtained with SPHERE. Methods. The relation between the gap and the planet is due to the chaotic zone neighboring the orbit of the planet. The radial extent of this zone depends on the mass ratio between the planet and the star, on the semi-major axis, and on the eccentricity of the planet, and it can be estimated analytically. We first tested the different analytical predictions using a numerical tool for the detection of chaotic behavior and then selected the best formula for estimating a planet's physical and dynamical properties required to open the observed gap. We then apply the formalism to the case of one single planet on a circular or eccentric orbit. We then consider multi-planetary systems: two and three equal-mass planets on circular orbits and two equal-mass planets on eccentric orbits in a packed configuration. As a final step, we compare each couple of values (M-p, a(p)), derived from the dynamical analysis of single and multiple planetary models, with the detection limits obtained with SPHERE. Results. For one single planet on a circular orbit we obtain conclusive results that allow us to exclude such a hypothesis since in most cases this configuration requires massive planets which should have been detected by our observations. Unsatisfactory is also the case of one single planet on an eccentric orbit for which we obtained high masses and/or eccentricities which are still at odds with observations. Introducing multi planetary architectures is encouraging because for the case of three packed equal-mass planets on circular orbits we obtain quite low masses for the perturbing planets which would remain undetected by our SPHERE observations. The case of two equal-mass planets on eccentric orbits is also of interest since it suggests the possible presence of planets with masses lower than the detection limits and with moderate eccentricity. Our results show that the apparent lack of planets in gaps between double belts could be explained by the presence of a system of two or more planets possibly of low mass and on eccentric orbits whose sizes are below the present detection limits.
14.	Mesa, D., et al. (författare) Constraining masses and separations of unseen companions to five accelerating nearby stars star 2022 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665 Tidskriftsartikel (refereegranskat)abstract Aims. In this work, we aim to constrain the masses and separations of potential substellar companions to five accelerating stars (HIP 1481, HIP 88399, HIP 96334, HIP 30314, and HIP 116063) using multiple data sets acquired with different techniques.Methods. Our targets were originally observed as part of the SPHERE/SHINE survey, and radial velocity (RV) archive data were also available for four of the five objects. No companions were originally detected in any of these data sets, but the presence of significant proper motion anomalies (PMas) for all the stars strongly suggested the presence of a companion. Combining the information from the PMas with the limits derived from the RV and SPHERE data, we were able to put constraints on the characteristics of the unseen companions.Results. Our analysis led to relatively strong constraints for both HIP 1481 and HIP 88399, narrowing down the companion masses to 2–5 MJup and 3–5 MJup and separations within 2–15 au and 3–9 au, respectively. Because of the large age uncertainties for HIP 96334, the poor observing conditions for the SPHERE epochs of HIP 30314, and the lack of RV data for HIP 116063, the results for these targets were not as well defined, but we were still able to constrain the properties of the putative companions within a reasonable confidence level.Conclusions. For all five targets, our analysis reveals that the companions responsible for the PMa signal would be well within reach for future instruments planned for the ELT (e.g., MICADO), which would easily achieve the required contrast and angular resolution. Our results therefore represent yet another confirmation of the power of multi-technique approaches for both the discovery and characterisation of planetary systems.
15.	Mesa, D., et al. (författare) Upper limits for mass and radius of objects around Proxima Cen from SPHERE/VLT 2017 Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3925 .- 1745-3933. ; 466:1, s. l118-L122 Tidskriftsartikel (refereegranskat)abstract The recent discovery of an earth-like planet around Proxima Centauri has drawn much attention to this star and its environment. We performed a series of observations of Proxima Centauri using Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE), the planet-finder instrument installed at the European Southern Observatory (ESO) Very Large Telescope (VLT) UT3, using its near-infrared modules, InfraRed Dual-band Imager and Spectrograph (IRDIS) and IFS. No planet was detected directly, but we set upper limits on the mass up to 7 au by exploiting the AMES-COND models. Our IFS observations reveal that no planet more massive than similar to 6-7 M-Jup can be present within 1 au. The dual-band imaging camera IRDIS also enables us to probe larger separations than other techniques such as radial velocity or astrometry. We obtained mass limits of the order of 4 M-Jup at separations of 2 au or larger, representing the most stringent mass limits at separations larger than 5 au available at the moment. We also made an attempt to estimate the radius of possible planets around Proxima using the reflected light. Since the residual noise for the observations is dominated by photon noise and thermal background, longer exposures in good observing conditions could improve the achievable contrast limit further.
16.	Nguyen, Thanh N, et al. (författare) Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up. 2023 Ingår i: Neurology. - 1526-632X. ; 100:4 Tidskriftsartikel (refereegranskat)abstract Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations.There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.This study is registered under NCT04934020.
17.	Rodet, L., et al. (författare) Dynamical masses of M-dwarf binaries in young moving groups I. The case of TWA22 and GJ2060 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 618 Tidskriftsartikel (refereegranskat)abstract Context. Evolutionary models are widely used to infer the mass of stars, brown dwarfs, and giant planets. Their predictions are thought to be less reliable at young ages (<200 Myr) and in the low-mass regime (< 1 M-circle dot). GJ 2060AB and TWA22AB are two rare astrometric M-dwarf binaries, respectively members of the AB Doradus (AB Dor) and Beta Pictoris (beta Pic) moving groups. As their dynamical mass can be measured to within a few years, they can be used to calibrate the evolutionary tracks and set new constraints on the age of young moving groups.Aims. We provide the first dynamical mass measurement of GJ 2060 and a refined measurement of the total mass of TWA22. We also characterize the atmospheric properties of the individual components of GJ 2060 that can be used as inputs to the evolutionary models.Methods. We used NaCo and SPHERE observations at VLT and archival Keck/NIRC2 data to complement the astrometric monitoring of the binaries. We combined the astrometry with new HARPS radial velocities (RVs) and FEROS RVs of GJ 2060. We used a Markov chain MonteCarlo (MCMC) module to estimate posteriors on the orbital parameters and dynamical masses of GJ 2060AB and TWA22AB from the astrometry and RVs. Complementary data obtained with the integral field spectrograph VLT /SINFONI were gathered to extract the individual near-infrared (1.1-2.5 mu m) medium-resolution (R similar to 1500 2000) spectra of GJ 2060A and B. We compared the spectra to those of known objects and to grids of BT-SETTL model spectra to infer the spectral type, bolometric luminosities, and temperatures of those objects.Results. We find a total mass of 0 : 18 +/- 0 : 02 M-circle dot for TWA22, which is in good agreement with model predictions at the age of the fi Pic moving group. We obtain a total mass of 1 : 09 +/- 0 : 10 M-circle dot for GJ 2060. We estimate a spectral type of M1 +/- 0.5, L/L-circle dot = -1.20 +/- 0.05 dex, and T-eff = 3700 +/- 100 K for GJ 2060 A. The B component is a M3 +/- 0 : 5 dwarf with L/L-circle dot = 1.63 +/- 0.05 dex and T-eff = 3400 +/- 100 K. The dynamical mass of GJ 2060AB is inconsistent with the most recent models predictions (BCAH15, PARSEC) for an AB Dor age in the range 50-150 Myr. It is 10%-20% (1-2 sigma, depending on the assumed age) above the model's predictions, corresponding to an underestimation of 0.10-0.20 M fi. Coevality suggests a young age for the system (similar to 50 Myr) according to most evolutionary models.Conclusions. TWA22 validates the predictions of recent evolutionary tracks at similar to 20 Myr. On the other hand, we evidence a 1-2 sigma mismatch between the predicted and observed mass of GJ 2060 AB. This slight departure may indicate that one of the stars hosts a tight companion. Alternatively, this would confirm the model's tendency to underestimate the mass of young low-mass stars.
18.	Singh, G., et al. (författare) Revealing asymmetrical dust distribution in the inner regions of HD 141569 2021 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 653 Tidskriftsartikel (refereegranskat)abstract Context. The combination of high-contrast imaging with spectroscopy and polarimetry offers a pathway to studying the grain distribution and properties of debris disks in exquisite detail. Here, we focus on the case of a gas-rich debris disk around HD 141569A, which features a multiple-ring morphology first identified with SPHERE in the near-infrared.Aims. We obtained polarimetric differential imaging with SPHERE in the H-band to compare the scattering properties of the innermost ring at 44 au with former observations in total intensity with the same instrument. In polarimetric imaging, we observed that the intensity of the ring peaks in the south-east, mostly in the forward direction, whereas in total intensity imaging, the ring is detected only at the south. This noticeable characteristic suggests a non-uniform dust density in the ring. With these two sets of images, we aim to study the distribution of the dust to solve for the actual dust distribution.Methods. We implemented a density function varying azimuthally along the ring and generated synthetic images both in polarimetry and in total intensity, which are then compared to the actual data. The search for the best-fit model was performed both with a grid-based and an MCMC approach. Using the outcome of this modelization, we further measured the polarized scattering phase function for the observed scattering angle between 33 degrees and 147 degrees as well as the spectral reflectance of the southern part of the ring between 0.98 and 2.1 mu m. We tentatively derived the grain properties by comparing these quantities with MCFOST models and assuming Mie scattering.Results. We find that the dust density peaks in the south-west at an azimuthal angle of 220 degrees similar to 238 degrees with a rather broad width of 61 degrees similar to 127 degrees. The difference in the intensity distributions observed in polarimetry and total intensity is the result of this particular morphology. Although there are still uncertainties that remain in the determination of the anisotropic scattering factor, the implementation of an azimuthal density variation to fit the data proved to be robust. Upon elaborating on the origin of this dust density distribution, we conclude that it could be the result of a massive collision when we account for the effect of the high gas mass that is present in the system on the dynamics of grains. In terms of grain composition, our preliminary interpretation indicates a mixture of porous sub-micron sized astro-silicate and carbonaceous grains.Conclusions. The SPHERE observations have allowed, for the first time, for meaningful constraints to be placed on the dust distribution beyond the standard picture of a uniform ring-like debris disk. However, future studies with a multiwavelength approach and additional detailed modeling would be required to better characterize the grain properties in the HD 141569 system.
19.	Sissa, E., et al. (författare) High-contrast study of the candidate planets and protoplanetary disk around HD 100546 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 619 Tidskriftsartikel (refereegranskat)abstract The nearby Herbig Be star HD 100546 is known to be a laboratory for the study of protoplanets and their relation with the circum stellar disk, which is carved by at least two gaps. We observed the HD 100546 environment with high-contrast imaging exploiting several different observing modes of SPHERE, including data sets with and without coronagraphs, dual band imaging, integral field spectroscopy and polarimetry. The picture emerging from these different data sets is complex. Flux-conservative algorithm images clearly show the disk up to 200 au. More aggressive algorithms reveal several rings and warped arms that are seen overlapping the main disk. Some of these structures are found to lie at considerable height over the disk mid-plane at about 30 au. Our images demon-strate that the brightest wings close to the star in the near side of the disk are a unique structure, corresponding to the outer edge of the intermediate disk at similar to 40 au. Modeling of the scattered light from the disk with a geometrical algorithm reveals that a moderately thin structure (H/r = 0.18 at 40 au) can well reproduce the light distribution in the flux-conservative images. We suggest that the gap between 44 and 113 au spans between the 1:2 and 3:2 resonance orbits of a massive body located at similar to 70 au, which might coincide with the candidate planet HD 100546b detected with previous thermal infrared (IR) observations. In this picture, the two wings can be the near side of a ring formed by disk material brought out of the disk at the 1:2 resonance with the same massive object. While we find no clear evidence confirming detection of the planet candidate HD 100546c in our data, we find a diffuse emission close to the expected position of HD 100546b. This source can be described as an extremely reddened substellar object surrounded by a dust cloud or its circumplanetary disk. Its astrometry is broadly consistent with a circular orbital motion on the disk plane, a result that could be confirmed with new observations. Further observations at various wavelengths are required to fully understand the complex phenomenology of HD 100546.
20.	Vigan, A., et al. (författare) The SPHERE infrared survey for exoplanets (SHINE) : III. The demographics of young giant exoplanets below 300 au with SPHERE 2021 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 651 Tidskriftsartikel (refereegranskat)abstract The SpHere INfrared Exoplanet (SHINE) project is a 500-star survey performed with SPHERE on the Very Large Telescope for the purpose of directly detecting new substellar companions and understanding their formation and early evolution. Here we present an initial statistical analysis for a subsample of 150 stars spanning spectral types from B to M that are representative of the full SHINE sample. Our goal is to constrain the frequency of substellar companions with masses between 1 and 75 MJup and semimajor axes between 5 and 300 au. For this purpose, we adopt detection limits as a function of angular separation from the survey data for all stars converted into mass and projected orbital separation using the BEX-COND-hot evolutionary tracks and known distance to each system. Based on the results obtained for each star and on the 13 detections in the sample, we use a Markov chain Monte Carlo tool to compare our observations to two different types of models. The first is a parametric model based on observational constraints, and the second type are numerical models that combine advanced core accretion and gravitational instability planet population synthesis. Using the parametric model, we show that the frequencies of systems with at least one substellar companion are 23.0−9.7+13.5, 5.8−2.8+4.7, and 12.6−7.1+12.9% for BA, FGK, and M stars, respectively. We also demonstrate that a planet-like formation pathway probably dominates the mass range from 1–75 MJup for companions around BA stars, while for M dwarfs, brown dwarf binaries dominate detections. In contrast, a combination of binary star-like and planet-like formation is required to best fit the observations for FGK stars. Using our population model and restricting our sample to FGK stars, we derive a frequency of 5.7−2.8+3.8%, consistent with predictions from the parametric model. More generally, the frequency values that we derive are in excellent agreement with values obtained in previous studies.
21.	Zurlo, A., et al. (författare) Imaging radial velocity planets with SPHERE 2018 Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 480:1, s. 35-48 Tidskriftsartikel (refereegranskat)abstract We present observations with the planet finder Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) of a selected sample of the most promising radial velocity (RV) companions for high-contrast imaging. Using a Monte Carlo simulation to explore all the possible inclinations of the orbit of wide RV companions, we identified the systems with companions that could potentially be detected with SPHERE. We found the most favourable RV systems to observe are: HD 142, GJ 676, HD 39091, HIP 70849, and HD 30177 and carried out observations of these systems during SPHERE Guaranteed Time Observing. To reduce the intensity of the starlight and reveal faint companions, we used principal component analysis algorithms alongside angular and spectral differential imaging. We injected synthetic planets with known flux to evaluate the self-subtraction caused by our data reduction and to determine the 5 sigma contrast in the J band versus separation for our reduced images. We estimated the upper limit on detectable companion mass around the selected stars from the contrast plot obtained from our data reduction. Although our observations enabled contrasts larger than 15 mag at a few tenths of arcsec from the host stars, we detected no planets. However, we were able to set upper mass limits around the stars using AMES-COND evolutionary models. We can exclude the presence of companions more massive than 25-28M(Jup) around these stars, confirming the substellar nature of these RV companions.
22.	Zurlo, A., et al. (författare) Orbital and dynamical analysis of the system around HR 8799 New astrometric epochs from VLT/SPHERE and LBT/LUCI 2022 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 666 Tidskriftsartikel (refereegranskat)abstract Context. HR 8799 is a young planetary system composed of four planets and a double debris belt. Being the first multi-planetary system discovered with the direct imaging technique, it has been observed extensively since 1998. This wide baseline of astrometric measurements, counting over 50 observations in 20 years, permits a detailed orbital and dynamical analysis of the system.Aims. To explore the orbital parameters of the planets, their dynamical history, and the planet-to-disk interaction, we made follow-up observations of the system during the VLT/SPHERE guaranteed time observation program. We obtained 21 observations, most of them in favorable conditions. In addition, we observed HR 8799 with the instrument LUCI at the Large Binocular Telescope (LBT).Methods. All the observations were reduced with state-of-the-art algorithms implemented to apply the spectral and angular differential imaging method. We re-reduced the SPHERE data obtained during the commissioning of the instrument and in three open-time programs to have homogeneous astrometry. The precise position of the four planets with respect to the host star was calculated by exploiting the fake negative companions method. We obtained an astrometric precision of the order of 6 mas in the worst case and 1 mas in the best case. To improve the orbital fitting, we also took into account all of the astrometric data available in the literature. From the photometric measurements obtained in different wavelengths, we estimated the masses of the planets following the evolutionary models.Results. We obtained updated parameters for the orbits with the assumption of coplanarity, relatively small eccentricities, and periods very close to the 2:1 resonance. We also refined the dynamical mass of each planet and the parallax of the system (24.49 ± 0.07 mas), which overlap with the recent Gaia eDR3/DR3 estimate. Hydrodynamical simulations suggest that inward migration of the planets caused by the interaction with the disk might be responsible for the planets being locked in resonance. We also conducted detailed N-body simulations indicating possible positions of a putative fifth planet with a mass below the present detection limits of ≃3 MJup.
23.	Allen, David B, et al. (författare) GH Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults. 2016 Ingår i: European Journal of Endocrinology. - 1479-683X. ; 174:2, s. 1-9 Tidskriftsartikel (refereegranskat)abstract Recombinant human growth hormone (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that 'for approved indications, GH is safe'; however, the statement highlighted a number of areas for on-going surveillance of long-term safety including; cancer risk, impact on glucose homeostasis and use of high dose pharmacological rhGH treatment. Over the intervening years, there have been a number of publications addressing the safety of rhGH with regard to mortality, cancer and cardiovascular risk and the need for longterm surveillance of the increasing number of adults who were treated with rhGH in childhood. Against this backdrop of interest in safety, the European Society of Paediatric Endocrinology (ESPE), the GRS and the Pediatric Endocrine Society (PES) convened a meeting to reappraise the safety of rhGH. The ouput of the meeting is a concise position statement.
24.	Biller, B. A., et al. (författare) Dynamical masses for two M1 + mid-M dwarf binaries monitored during the SPHERE-SHINE survey 2022 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 658 Tidskriftsartikel (refereegranskat)abstract We present orbital fits and dynamical masses for HIP 113201AB and HIP 36985AB, two M1 + mid-M dwarf binary systems monitored as part of the SPHERE-SHINE survey. To robustly determine the age of both systems via gyrochronology, we undertook a photometric monitoring campaign for HIP 113201 and GJ 282AB, the two wide K star companions to HIP 36985, using the 40 cm Remote Observatory Atacama Desert telescope. Based on this monitoring and gyrochronological relationships, we adopt ages of 1.2 ± 0.1 Gyr for HIP 113201AB and 750 ± 100 Myr for HIP 36985AB. These systems are sufficiently old that we expect that all components of these binaries have reached the main sequence. To derive dynamical masses for all components of the HIP 113201AB and HIP 36985AB systems, we used parallel-tempering Markov chain Monte Carlo sampling to fit a combination of radial velocity, direct imaging, and Gaia and HIPPARCOS astrometry. Fitting the direct imaging and radial velocity data for HIP 113201 yields a primary mass of 0.54 ± 0.03 M⊙, fully consistent with its M1 spectral type, and a secondary mass of 0.145 ± M⊙. The secondary masses derived with and without including HIPPARCOS-Gaia data are all considerably more massive than the 0.1 M⊙ mass estimated from the photometry of the companion. Thus, the dynamical impacts of this companion suggest that it is more massive than expected from its photometry. An undetected brown dwarf companion to HIP 113201B could be a natural explanation for this apparent discrepancy. At an age >1 Gyr, a 30 MJup companion to HIP 113201B would make a negligible (<1%) contribution to the system luminosity but could have strong dynamical impacts. Fitting the direct imaging, radial velocity, and HIPPARCOS-Gaia proper motion anomaly for HIP 36985AB, we find a primary mass of 0.54 ± 0.01 M⊙ and a secondary mass of 0.185 ± 0.001 M⊙, which agree well with photometric estimates of component masses, the masses estimated from MK– mass relationships for M dwarf stars, and previous dynamical masses in the literature.
25.	Boccaletti, A., et al. (författare) Observations of fast-moving features in the debris disk of AU Mic on a three-year timescale : Confirmation and new discoveries 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 614 Tidskriftsartikel (refereegranskat)abstract Context. The nearby and young M star AU Mic is surrounded by a debris disk in which we previously identified a series of large-scale arch-like structures that have never been seen before in any other debris disk and that move outward at high velocities. Aims. We initiated a monitoring program with the following objectives: (1) track the location of the structures and better constrain their projected speeds, (2) search for new features emerging closer in, and ultimately (3) understand the mechanism responsible for the motion and production of the disk features. Methods. AU Mic was observed at 11 different epochs between August 2014 and October 2017 with the IR camera and spectrograph of SPHERE. These high-contrast imaging data were processed with a variety of angular, spectral, and polarimetric differential imaging techniques to reveal the faintest structures in the disk. We measured the projected separations of the features in a systematic way for all epochs. We also applied the very same measurements to older observations from the Hubble Space Telescope (HST) with the visible cameras STIS and ACS. Results. The main outcomes of this work are (1) the recovery of the five southeastern broad arch-like structures we identified in our first study, and confirmation of their fast motion (projected speed in the range 4-12 km s(-1) ); (2) the confirmation that the very first structures observed in 2004 with ACS are indeed connected to those observed later with STIS and now SPHERE; (3) the discovery of two new very compact structures at the northwest side of the disk (at 0.40 '' and 0.55 '' in May 2015) that move to the southeast at low speed; and (4) the identification of a new arch-like structure that might be emerging at the southeast side at about 0.4 from the star (as of May 2016). Conclusions. Although the exquisite sensitivity of SPHERE allows one to follow the evolution not only of the projected separation, but also of the specific morphology of each individual feature, it remains difficult to distinguish between possible dynamical scenarios that may explain the observations. Understanding the exact origin of these features, the way they are generated, and their evolution over time is certainly a significant challenge in the context of planetary system formation around M stars.
26.	Boguszewski, M. C. S., et al. (författare) Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement 2022 Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 186:6 Tidskriftsartikel (refereegranskat)abstract Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concerns regarding the safety of GH replacement in children and adults who have received treatment for cancer and those with intracranial and pituitary tumours. A consensus statement was produced to guide decision-making on GH replacement in children and adult survivors of cancer, in those treated for intracranial and pituitary tumours and in patients with increased cancer risk. With the support of the European Society of Endocrinology, the Growth Hormone Research Society convened a Workshop, where 55 international key opinion leaders representing 10 professional societies were invited to participate. This consensus statement utilized: (1) a critical review paper produced before the Workshop, (2) five plenary talks, (3) evidence-based comments from four breakout groups, and (4) discussions during report-back sessions. Current evidence reviewed from the proceedings from the Workshop does not support an association between GH replacement and primary tumour or cancer recurrence. The effect of GH replacement on secondary neoplasia risk is minor compared to host- and tumour treatment-related factors. There is no evidence for an association between GH replacement and increased mortality from cancer amongst GH-deficient childhood cancer survivors. Patients with pituitary tumour or craniopharyngioma remnants receiving GH replacement do not need to be treated or monitored differently than those not receiving GH. GH replacement might be considered in GH-deficient adult cancer survivors in remission after careful individual risk/benefit analysis. In children with cancer predisposition syndromes, GH treatment is generally contraindicated but may be considered cautiously in select patients.
27.	Bolmstedt, A, et al. (författare) Enhanced immunogenicity of a human immunodeficiency virus type 1 env DNA vaccine by manipulating N-glycosylation signals. Effects of elimination of the V3 N306 glycan 2001 Ingår i: Vaccine. - 0264-410X. ; 20:3-4, s. 397-405 Tidskriftsartikel (refereegranskat)
28.	Bonavita, M., et al. (författare) New binaries from the SHINE survey 2022 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 663 Tidskriftsartikel (refereegranskat)abstract We present the multiple stellar systems observed within the SpHere INfrared survey for Exoplanet (SHINE). SHINE searched for sub-stellar companions to young stars using high contrast imaging. Although stars with known stellar companions within the SPHERE field of view (< 5.5 arcsec) were removed from the original target list, we detected additional stellar companions to 78 of the 463 SHINE targets observed so far. Twenty-seven per cent of the systems have three or more components. Given the heterogeneity of the sample in terms of observing conditions and strategy, tailored routines were used for data reduction and analysis, some of which were specifically designed for these datasets. We then combined SPHERE data with literature and archival data, TESS light curves, and Gaia parallaxes and proper motions for an accurate characterisation of the systems. Combining all data, we were able to constrain the orbits of 25 systems. We carefully assessed the completeness of our sample for separations between 50–500 mas (corresponding to periods of a few years to a few decades), taking into account the initial selection biases and recovering part of the systems excluded from the original list due to their multiplicity. This allowed us to compare the binary frequency for our sample with previous studies and highlight interesting trends in the mass ratio and period distribution. We also found that, when such an estimate was possible, the values of the masses derived from dynamical arguments were in good agreement with the model predictions. Stellar and orbital spins appear fairly well aligned for the 12 stars that have enough data, which favours a disk fragmentation origin. Our results highlight the importance of combining different techniques when tackling complex problems such as the formation of binaries and show how large samples can be useful for more than one purpose.
29.	Claudi, R., et al. (författare) SPHERE dynamical and spectroscopic characterization of HD142527B 2019 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 622 Tidskriftsartikel (refereegranskat)abstract Aims. HD142527 is one of the most frequently studied Herbig Ae/Be stars with a transitional disk that hosts a large cavity that is up to about 100 au in radius. For this reason, it has been included in the guaranteed time observation (GTO) SpHere INfrared survey for Exoplanets (SHINE) as part of the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) at the Very Large Telescope (VLT) in order to search for low-mass companions that might explain the presence of the gap. SHINE is a large survey within about 600 young nearby stars are observed with SPHERE with the aim to constrain the occurrence and orbital properties of the giant planet population at large (>5 au) orbital separation around young stars. Methods. We used the IRDIFS observing mode of SPHERE (IRDIS short for infrared dual imaging and spectrograph plus IFS or integral field spectrograph) without any coronagraph in order to search for and characterize companions as close as 30 mas of the star. Furthermore, we present the first observations that ever used the sparse aperture mask (SAM) for SPHERE both in IRDIFS and IRDIFS_EXT modes. All the data were reduced using the dedicated SPHERE pipeline and dedicated algorithms that make use of the principal component analysis (PCA) and reference differential imaging (RDI) techniques. Results. We detect the accreting low-mass companion HD142527B at a separation of 73 mas (11.4 au) from the star. No other companions with mass greater than 10 M-J are visible in the field of view of IFS (similar to 100 au centered on the star) or in the IRDIS field of view (similar to 400 au centered on the star). Measurements from IFS, SAM IFS, and IRDIS suggest an M6 spectral type for HD142527B, with an uncertainty of one spectral subtype, compatible with an object of M = 0.11 +/- 0.06 M-circle dot and R = 0.15 +/- 0.07 R-circle dot. The determination of the mass remains a challenge using contemporary evolutionary models, as they do not account for the energy input due to accretion from infalling material. We consider that the spectral type of the secondary may also be earlier than the type we derived from IFS spectra. From dynamical considerations, we further constrain the mass to 0.26(-0.14)(+0.16) , which is consistent with both our spectroscopic analysis and the values reported in the literature. Following previous methods, the lower and upper dynamical mass values correspond to a spectral type between M2.5 and M5.5 for the companion. By fitting the astrometric points, we find the following orbital parameters: a period of P = 35 137 yr; an inclination of i = 121 130 degrees, a value of Omega = 124 135 degrees for the longitude of node, and an 68% confidence interval of similar to 18-57 au for the separation at periapsis. Eccentricity and time at periapsis passage exhibit two groups of values: similar to 0.2-0.45 and similar to 0.45-0.7 for e, and similar to 2015-2020 and similar to 2020-2022 for T-0. While these orbital parameters might at first suggest that HD142527B is not the companion responsible for the outer disk truncation, a previous hydrodynamical analysis of this system showed that they are compatible with a companion that is able to produce the large cavity and other observed features.
30.	Collett-Solberg, Paulo F., et al. (författare) Diagnosis, Genetics, and Therapy of Short Stature in Children : A Growth Hormone Research Society International Perspective 2019 Ingår i: Hormone Research in Paediatrics. - : S. Karger. - 1663-2818 .- 1663-2826. ; 92:1, s. 1-14 Tidskriftsartikel (refereegranskat)abstract The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency.
31.	Desgrange, C., et al. (författare) In-depth direct imaging and spectroscopic characterization of the young Solar System analog HD 95086 2022 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 664 Tidskriftsartikel (refereegranskat)abstract Context. HD 95086 is a young nearby Solar System analog hosting a giant exoplanet orbiting at 57 au from the star between an inner and outer debris belt. The existence of additional planets has been suggested as the mechanism that maintains the broad cavity between the two belts.Aims. We present a dedicated monitoring of HD 95086 with the VLT/SPHERE instrument to refine the orbital and atmospheric properties of HD 95086 b, and to search for additional planets in this system.Methods. SPHERE observations, spread over ten epochs from 2015 to 2019 and including five new datasets, were used. Combined with archival observations, from VLT/NaCo (2012-2013) and Gemini/GPI (2013-2016), the extended set of astrometric measurements allowed us to refine the orbital properties of HD 95086 b. We also investigated the spectral properties and the presence of a circumplanetary disk around HD 95086 b by using the special fitting tool exploring the diversity of several atmospheric models. In addition, we improved our detection limits in order to search for a putative planet c via the K-Stacker algorithm.Results. We extracted for the first time the JH low-resolution spectrum of HD 95086 b by stacking the six best epochs, and confirm its very red spectral energy distribution. Combined with additional datasets from GPI and NaCo, our analysis indicates that this very red color can be explained by the presence of a circumplanetary disk around planet b, with a range of high-temperature solutions (1400–1600 K) and significant extinction (Av ≳ 10 mag), or by a super-solar metallicity atmosphere with lower temperatures (800–300 K), and small to medium amount of extinction (Av ≲ 10 mag). We do not find any robust candidates for planet c, but give updated constraints on its potential mass and location.
32.	Galicher, R., et al. (författare) Astrometric and photometric accuracies in high contrast imaging : The SPHERE speckle calibration tool (SpeCal) 2018 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 615 Tidskriftsartikel (refereegranskat)abstract Context. The consortium of the Spectro-Polarimetric High-contrast Exoplanet REsearch installed at the Very Large Telescope (SPHERE/VLT) has been operating its guaranteed observation time (260 nights over five years) since February 2015. The main part of this time (200 nights) is dedicated to the detection and characterization of young and giant exoplanets on wide orbits. Aims. The large amount of data must be uniformly processed so that accurate and homogeneous measurements of photometry and astrometry can be obtained for any source in the field. Methods. To complement the European Southern Observatory pipeline, the SPHERE consortium developed a dedicated piece of software to process the data. First, the software corrects for instrumental artifacts. Then, it uses the speckle calibration tool (SpeCal) to minimize the stellar light halo that prevents us from detecting faint sources like exoplanets or circumstellar disks. SpeCal is meant to extract the astrometry and photometry of detected point-like sources (exoplanets, brown dwarfs, or background sources). SpeCal was intensively tested to ensure the consistency of all reduced images (cADI, Loci, TLoci, PCA, and others) for any SPHERE observing strategy (ADI, SDI, ASDI as well as the accuracy of the astrometry and photometry of detected point-like sources. Results. SpeCal is robust, user friendly, and efficient at detecting and characterizing point-like sources in high contrast images. It is used to process all SPHERE data systematically, and its outputs have been used for most of the SPHERE consortium papers to date. SpeCal is also a useful framework to compare different algorithms using various sets of data (different observing modes and conditions). Finally, our tests show that the extracted astrometry and photometry are accurate and not biased.
33.	Grandjean, A., et al. (författare) Constraining the properties of HD 206893 B A combination of radial velocity, direct imaging, and astrometry data 2019 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 627 Tidskriftsartikel (refereegranskat)abstract Context. High contrast imaging enables the determination of orbital parameters for substellar companions (planets, brown dwarfs) from the observed relative astrometry and the estimation of model and age-dependent masses from their observed magnitudes or spectra. Combining astrometric positions with radial velocity gives direct constraints on the orbit and on the dynamical masses of companions. A brown dwarf was discovered with the VLT/SPHERE instrument at the Very Large Telescope (VLT) in 2017, which orbits at similar to 11 au around HD 206893. Its mass was estimated between 12 and 50 M-J from evolutionary models and its photometry. However, given the significant uncertainty on the age of the system and the peculiar spectrophotometric properties of the companion, this mass is not well constrained. Aims. We aim at constraining the orbit and dynamical mass of HD 206893 B. Methods. We combined radial velocity data obtained with HARPS spectra and astrometric data obtained with the high contrast imaging VLT/SPHERE and VLT/NaCo instruments, with a time baseline less than three years. We then combined those data with astrometry data obtained by HIPPARCOS and Gaia with a time baseline of 24 yr. We used a Markov chain Monte Carlo approach to estimate the orbital parameters and dynamical mass of the brown dwarf from those data. Results. We infer a period between 21 and 33 yr and an inclination in the range 20-41 degrees from pole-on from HD 206893 B relative astrometry. The RV data show a significant RV drift over 1.6 yr. We show that HD 206893 B cannot be the source of this observed RV drift as it would lead to a dynamical mass inconsistent with its photometry and spectra and with HIPPARCOS and Gaia data. An additional inner (semimajor axis in the range 1.4-2.6 au) and massive (similar to 15 M-J) companion is needed to explain the RV drift, which is compatible with the available astrometric data of the star, as well as with the VLT/SPHERE and VLT/NaCo nondetection.
34.	Gunnarsson, C., et al. (författare) Health Care Burden in Patients With Adrenal Insufficiency 2017 Ingår i: Journal of the Endocrine Society. - : The Endocrine Society. - 2472-1972. ; 1:5, s. 512-523 Tidskriftsartikel (refereegranskat)abstract Objective: This study aimed to estimate the annual health care burden for patients with adrenal insufficiency [AI; primary (PAI), secondary to pituitary disorder (PIT), and congenital adrenal hyperplasia (CAH)] using real-world data. Methods: Using a US-based payer database comprising >108 million members, strict inclusion criteria with diagnostic codes and pharmacy records were used to identify 10,383 patients with AI. This included 1014 patients with PAI, 8818 with PIT, and 551 with CAH, followed for >12 months. Patients were matched 1:1 to controls, based on age (+/- 5 years), sex, insurance, and region. Multivariable expenditure models were estimated for each AI cohort vs controls as well as subsets by glucocorticoid therapy (hydrocortisone, dexamethasone, prednisone, or multiple therapies). A separate multivariable model was estimated to assess the association between adherence and expenditures. Results: Total annual health care expenditure estimates were significantly higher (P < 0.0001) in all AI cohorts compared with matched controls (PAI $18,624 vs $4320, PIT $32,218 vs $6956, CAH $7677 vs $4203). Patients with AI have more frequent inpatient hospital stays with up to eight to 10 times more days in the hospital per year than their matched controls. In each AI cohort, patients on multiple steroid therapies had higher expenditures in comparison with patients using hydrocortisone therapy alone. In PAI and PIT cohorts taking hydrocortisone only, fewer expenditures were found in higher adherence subsets. Conclusion: Patients with AI demonstrate a substantial annual health care burden. Expenditures vary by underlying cause and treatment and are reduced in patients with higher adherence to glucocorticoid replacement. Copyright (c) 2017 Endocrine Society
35.	Hinkley, Sasha, et al. (författare) The JWST Early Release Science Program for the Direct Imaging and Spectroscopy of Exoplanetary Systems 2022 Ingår i: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 134:1039 Tidskriftsartikel (refereegranskat)abstract The direct characterization of exoplanetary systems with high-contrast imaging is among the highest priorities for the broader exoplanet community. As large space missions will be necessary for detecting and characterizing exo-Earth twins, developing the techniques and technology for direct imaging of exoplanets is a driving focus for the community. For the first time, JWST will directly observe extrasolar planets at mid-infrared wavelengths beyond 5 μm, deliver detailed spectroscopy revealing much more precise chemical abundances and atmospheric conditions, and provide sensitivity to analogs of our solar system ice-giant planets at wide orbital separations, an entirely new class of exoplanet. However, in order to maximize the scientific output over the lifetime of the mission, an exquisite understanding of the instrumental performance of JWST is needed as early in the mission as possible. In this paper, we describe our 55 hr Early Release Science Program that will utilize all four JWST instruments to extend the characterization of planetary-mass companions to ∼15 μm as well as image a circumstellar disk in the mid-infrared with unprecedented sensitivity. Our program will also assess the performance of the observatory in the key modes expected to be commonly used for exoplanet direct imaging and spectroscopy, optimize data calibration and processing, and generate representative data sets that will enable a broad user base to effectively plan for general observing programs in future Cycles.
36.	Johannsson, Gudmundur, 1960, et al. (författare) Growth Hormone Research Society perspective on biomarkers of GH action in children and adults 2018 Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 7:3 Tidskriftsartikel (refereegranskat)abstract Objective: The Growth Hormone Research Society (GRS) convened a Workshop in 2017 to evaluate clinical endpoints, surrogate endpoints and biomarkers during GH treatment of children and adults and in patients with acromegaly. Participants: GRS invited 34 international experts including clinicians, basic scientists, a regulatory scientist and physicians from the pharmaceutical industry. Evidence: Current literature was reviewed and expert opinion was utilized to establish the state of the art and identify current gaps and unmet needs. Consensus process: Following plenary presentations, breakout groups discussed questions framed by the planning committee. The attendees re-convened after each breakout session to share the group reports. A writing team compiled the breakout session reports into a document that was subsequently discussed and revised by participants. This was edited further and circulated for final review after the meeting. Participants from pharmaceutical companies were not part of the writing process. Conclusions: The clinical endpoint in paediatric GH treatment is adult height with height velocity as a surrogate endpoint. Increased life expectancy is the ideal but unfeasible clinical endpoint of GH treatment in adult GH-deficient patients (GHDA) and in patients with acromegaly. The pragmatic clinical endpoints in GHDA include normalization of body composition and quality of life, whereas symptom relief and reversal of comorbidities are used in acromegaly. Serum IGF-I is widely used as a biomarker, even though it correlates weakly with clinical endpoints in GH treatment, whereas in acromegaly, normalization of IGF-I may be related to improvement in mortality. There is an unmet need for novel biomarkers that capture the pleiotropic actions of GH in relation to GH treatment and in patients with acromegaly.
37.	Johannsson, Gudmundur, 1960, et al. (författare) Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency : a prospective randomised trial of a novel hydrocortisone dual-release formulation 2012 Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 97:2, s. 473-481 Tidskriftsartikel (refereegranskat)abstract Context: Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.Objective: The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of conventional hydrocortisone tablets.Design and Setting: We conducted an open, randomized, two-period, 12-wk crossover multicenter trial with a 24-wk extension at five university hospital centers.Patients: The trial enrolled 64 adults with primary AI; 11 had concomitant diabetes mellitus (DM).Intervention: The same daily dose of hydrocortisone was administered as OD dual-release or TID.Main Outcome Measure: We evaluated cortisol pharmacokinetics.Results: Compared with conventional TID, OD provided a sustained serum cortisol profile 0-4 h after the morning intake and reduced the late afternoon and the 24-h cortisol exposure. The mean weight (difference = -0.7 kg, P = 0.005), systolic blood pressure (difference = -5.5 mm Hg, P = 0.0001) and diastolic blood pressure (difference: -2.3 mm Hg; P = 0.03), and glycated hemoglobin (absolute difference = -0.1%, P = 0.0006) were all reduced after OD compared with TID at 12 wk. Compared with TID, a reduction in glycated hemoglobin by 0.6% was observed in patients with concomitant DM during OD (P = 0.004).Conclusion: The OD dual-release tablet provided a more circadian-based serum cortisol profile. Reduced body weight, reduced blood pressure, and improved glucose metabolism were observed during OD treatment. In particular, glucose metabolism improved in patients with concomitant DM.
38.	Johannsson, Gudmundur, 1960, et al. (författare) Once-weekly Somapacitan is Effective and Well Tolerated in Adults with GH Deficiency: A Randomized Phase 3 Trial. 2020 Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 105:4 Tidskriftsartikel (refereegranskat)abstract Growth hormone (GH) replacement requires daily GH injections, which is burdensome for some adult patients with GH deficiency (AGHD).To demonstrate efficacy and safety of somapacitan, a once-weekly reversible albumin-binding GH derivative, versus placebo in AGHD.Randomized, parallel-group, placebo-controlled (double-blind) and active-controlled (open-label) phase 3 trial, REAL 1 (NCT02229851).Clinics in 17 countries.Treatment-naïve patients with AGHD (n = 301 main study period, 272 extension period); 257 patients completed the trial.Patients were randomized 2:2:1 to once-weekly somapacitan, daily GH, or once-weekly placebo for 34 weeks (main period). During the 52-week extension period, patients continued treatment with somapacitan or daily GH.Body composition measured using dual-energy x-ray absorptiometry (DXA). The primary endpoint was change in truncal fat percentage to week 34. Insulin-like growth factor 1 (IGF-I) standard deviation score (SDS) values were used to dose titrate.At 34 weeks, somapacitan significantly reduced truncal fat percentage (estimated difference: -1.53% [-2.68; -0.38]; P = 0.0090), demonstrating superiority compared with placebo, and it improved other body composition parameters (including visceral fat and lean body mass) and IGF-I SDS. At 86 weeks, improvements were maintained with both somapacitan and daily GH. Somapacitan was well tolerated, with similar adverse events (including injection-site reactions) compared with daily GH.In AGHD patients, somapacitan administered once weekly demonstrated superiority over placebo, and the overall treatment effects and safety of somapacitan were in accordance with known effects and safety of GH replacement for up to 86 weeks of treatment. Somapacitan may provide an effective alternative to daily GH in AGHD. A short visual summary of our work is available (1).
39.	Kildemoes, R. J., et al. (författare) Dose-exposure-IGF-I response of once-weekly somapacitan in adults with GH deficiency 2022 Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 187:1, s. 27-38 Tidskriftsartikel (refereegranskat)abstract Objective: Growth hormone (GH) replacement therapy in patients with adult growth hormone deficiency (AGHD) is individually titrated due to variable dose-responses among patients. The aim of this study was to provide clinical guidance on dosing and titration of the novel long-acting GH derivative somapacitan based on analyses of somapacitan dose-insulin-like growth factor I (IGF-I) responses in AGHD patients. Design: Analyses of dosing information, 4364 somapacitan concentration samples and 4880 IGF-I samples from 330 AGHD patients treated with somapacitan in three phase 3 trials. Methods: Pharmacokinetic/pharmacodynamic modelling was used to evaluate starting dose groups by age and oral oestrogen therapy, characterise the dose-IGF-I response in the overall AGHD population and patient subgroups, predict the IGF-I response to dose changes and simulate missed dosing. Results: The analyses supported the clinical recommendations of higher starting doses for younger patients and women on oral oestrogen replacement therapy. For patients switching from daily GH treatment, the mean maintenance dose ratio between somapacitan (mg/week) and somatropin (mg/day) was predicted to be 8.2 (observed interquartile range of 6.7-9.1). Simulations of IGF-I SDS profiles confirmed the appropriate time for IGF-I sampling to be 3-4 days after somapacitan dosing and supported somapacitan administration with up to 3 days delay in case of missed dosing. Subgroup analyses characterised the dose-exposure-IGF-I response in patient subgroups and indicated that dose requirements are mainly influenced by sex and oral oestrogen treatment. Conclusions: This study extends the knowledge of the somapacitan dose-IGF-I response and provides information on clinical dosing of once-weekly somapacitan in patients with AGHD.
40.	Lazzoni, C., et al. (författare) The search for disks or planetary objects around directly imaged companions : a candidate around DH Tauri B 2020 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 641 Tidskriftsartikel (refereegranskat)abstract Context. In recent decades, thousands of substellar companions have been discovered with both indirect and direct methods of detection. While the majority of the sample is populated by objects discovered using radial velocity and transit techniques, an increasing number have been directly imaged. These planets and brown dwarfs are extraordinary sources of information that help in rounding out our understanding of planetary systems.Aims. In this paper, we focus our attention on substellar companions detected with the latter technique, with the primary goal of investigating their close surroundings and looking for additional companions and satellites, as well as disks and rings. Any such discovery would shed light on many unresolved questions, particularly with regard to their possible formation mechanisms.Methods. To reveal bound features of directly imaged companions, whether for point-like or extended sources, we need to suppress the contribution from the source itself. Therefore, we developed a method based on the negative fake companion technique that first estimates the position in the field of view (FoV) and the flux of the imaged companion with high precision, then subtracts a rescaled model point spread function (PSF) from the imaged companion, using either an image of the central star or another PSF in the FoV. Next it performs techniques, such as angular differential imaging, to further remove quasi-static patterns of the star (i.e., speckle contaminants) that affect the residuals of close-in companions.Results. After testing our tools on simulated companions and disks and on systems that were chosen ad hoc, we applied the method to the sample of substellar objects observed with SPHERE during the SHINE GTO survey. Among the 27 planets and brown dwarfs we analyzed, most objects did not show remarkable features, which was as expected, with the possible exception of a point source close to DH Tau B. This candidate companion was detected in four different SPHERE observations, with an estimated mass of ~1MJup, and a mass ratio with respect to the brown dwarf of 1∕10. This binary system, if confirmed, would be the first of its kind, opening up interesting questions for the formation mechanism, evolution, and frequency of such pairs. In order to address the latter, the residuals and contrasts reached for 25 companions in the sample of substellar objects observed with SPHERE were derived. If the DH Tau Bb companion is real, the binary fraction obtained is ~7%, which is in good agreement with the results obtained for field brown dwarfs.Conclusions. While there may currently be many limitations affecting the exploration of bound features to directly imaged exoplanets and brown dwarfs, next-generation instruments from the ground and space (i.e., JWST, ELT, and LUVOIR) will be able to image fainter objects and, thus, drive the application of this technique in upcoming searches for exo-moons and circumplanetary disks.
41.	Ligi, R., et al. (författare) Investigation of the inner structures around HD 169142 with VLT/SPHERE 2018 Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 473:2, s. 1774-1783 Tidskriftsartikel (refereegranskat)abstract We present observations of the Herbig Ae star HD 169142 with the VLT/SPHERE instruments InfraRed Dual-band Imager and Spectrograph (IRDIS) (K1K2 and H2H3 bands) and the Integral Field Spectrograph (IFS) (Y, J and H bands). We detect several bright blobs at similar to 180 mas separation from the star, and a faint arc-like structure in the IFS data. Our reference differential imaging (RDI) data analysis also finds a bright ring at the same separation. We show, using a simulation based on polarized light data, that these blobs are actually part of the ring at 180 mas. These results demonstrate that the earlier detections of blobs in the H and K-S bands at these separations in Biller et al. as potential planet/substellar companions are actually tracing a bright ring with a Keplerian motion. Moreover, we detect in the images an additional bright structure at similar to 93 mas separation and position angle of 355 degrees, at a location very close to previous detections. It appears point-like in the YJ and K bands but is more extended in the H band. We also marginally detect an inner ring in the RDI data at similar to 100 mas. Follow-up observations are necessary to confirm the detection and the nature of this source and structure.
42.	Maire, A-L, et al. (författare) Hint of curvature in the orbital motion of the exoplanet 51 Eridani b using 3 yr of VLT/SPHERE monitoring 2019 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 624 Tidskriftsartikel (refereegranskat)abstract Context. The 51 Eridani system harbors a complex architecture with its primary star forming a hierarchical system with the binary GJ 3305AB at a projected separation of 2000 au, a giant planet orbiting the primary star at 13 au, and a low-mass debris disk around the primary star with possible cold and warm components inferred from the spectral energy distribution. Aims. We aim to better constrain the orbital parameters of the known giant planet. Methods. We monitored the system over three years from 2015 to 2018 with the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument at the Very Large Telescope (VET). Results. We measure an orbital motion for the planet of similar to 130 mas with a slightly decreasing separation (similar to 10 mas) and find a hint of curvature. This potential curvature is further supported at 3 sigma significance when including literature Gemini Planet Imager (GPI) astrometry corrected for calibration systematics. Fits of the SPHERE and GPI data using three complementary approaches provide broadly similar results. The data suggest an orbital period of 32(-9)(+17) yr (i.e., 12(-2)(+4), au in semi-major axis), an inclination of 133(-7)(+1)(4) deg, an eccentricity of 0.45(-0.15)(+0.10), and an argument of periastron passage of 87(-30)(+34) deg [mod 180 degrees]. The time at periastron passage and the longitude of node exhibit bimodal distributions because we do not yet detect whether the planet is accelerating or decelerating along its orbit. Given the inclinations of the orbit and of the stellar rotation axis (134-144 degrees), we infer alignment or misalignment within 18 degrees for the star-planet spin-orbit. Further astrometric monitoring in the next 3-4 yr is required to confirm at a higher significance the curvature in the motion of the planet, determine if the planet is accelerating or decelerating on its orbit, and further constrain its orbital parameters and the star-planet spin-orbit.
43.	Mizuki, T., et al. (författare) Orbital Characterization of GJ1108A System, and Comparison of Dynamical Mass with Model-derived Mass for Resolved Binaries 2018 Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 865:2 Tidskriftsartikel (refereegranskat)abstract We report an orbital characterization of GJ1108Aab that is a low-mass binary system in the pre-main-sequence phase. Via the combination of astrometry using adaptive optics and radial velocity measurements, an eccentric orbital solution of e = 0.63 is obtained, which might be induced by the Kozai-Lidov mechanism with a widely separated GJ1108B system. Combined with several observed properties, we confirm that the system is indeed young. Columba is the most probable moving group, to which the GJ1108A system belongs, although its membership to the group has not been established. If the age of Columba is assumed for GJ1108A, the dynamical masses of both GJ1108Aa and GJ1108Ab (M-dynamical,M-GJ1108Aa= 0.72 +/- 0.04 M-circle dot and M-dynamical,M-GJ1108Ab = 0.30 +/- 0.03 M-circle dot) are more massive than what an evolutionary model predicts based on the age and luminosities. We consider that the discrepancy in mass comparison can be attributed to an age uncertainty; the system is likely older than stars in Columba, and effects that are not implemented in classical models such as accretion history and magnetic activity are not preferred to explain the mass discrepancy. We also discuss the performance of the evolutionary model by compiling similar low-mass objects in the evolutionary state based on the literature. Consequently, it is suggested that the current model on average reproduces the mass of resolved low-mass binaries without any significant offsets.
44.	Nguyen, TN, et al. (författare) Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up 2023 Ingår i: Neurology. - 1526-632X. ; 100:4, s. e408-e421 Tidskriftsartikel (refereegranskat)
45.	Petrus, S., et al. (författare) A new take on the low-mass brown dwarf companions on wide orbits in Upper-Scorpius 2020 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 633 Tidskriftsartikel (refereegranskat)abstract Context. The Upper-Scorpius association (5-11 Myr) contains a unique population of low-mass (M <= 30M(Jup)) brown dwarfs either free-floating, forming wide pairs, or on wide orbits around solar-type and massive stars. The detailed relative characterization of their physical properties (mass, radius, temperature, composition, and ongoing accretion) offers the opportunity to potentially explore their origin and mechanisms of formation. Aims. In this study, we aim to characterize the chemical and physical properties of three young, late-M brown dwarfs claimed to be companions of the Upper-Scorpius stars USco 161031.9-16191305, HIP 77900, and HIP 78530 using medium-resolution spectroscopy at UV (0.30-0.56 mu m; R-lambda similar to 3300), optical (0.55-1.02 mu m; R-lambda similar to 5400), and NIR (1.02-2.48 mu m; R-lambda similar to 4300) wavelengths. The spectra of six free-floating analogs from the same association are analyzed for comparison and to explore the potential physical differences between these substellar objects found in different configurations. We also aim to examine and analyze hydrogen emission lines at UV and optical wavelengths to investigate the presence of ongoing accretion processes. Methods. The X-shooter spectrograph at VLT was used to obtain the spectra of the nine young brown dwarfs over the 0.3-2.5 mu m range simultaneously. Performing a forward modeling of the observed spectra with the ForMoSA code, we infer the T-eff, log (g), and radius of our objects. The code compares here the BT-SETTL15 models to the observed spectra using the Nested Sampling Bayesian inference method. Mass is determined using evolutionary models, and a new analysis of the physical association is presented based on Gaia-DR2 astrometry. Results. The T-eff and log (g) determined for our companions are compatible with those found for free-floating analogs of the Upper-Scorpius association and with evolutionary model predictions at the age of the association. However the final accuracy on the T-eff estimates is strongly limited by nonreproducibility of the BT-SETTL15 models in the range of T-eff corresponding to the M8-M9 spectral types. We identified H alpha, H-beta, H-gamma, and Ca II H and K emission lines in the spectrum of several objects. We attribute these lines to chromospheric activity except for the free-floating object USco 1608-2315 for which they are indicative of active accretion (M <= 10(-10.76) M(circle dot)yr(-1)). We confirm the four-fold over-luminosity of USco 161031.9-16191305 B down to 0.3 mu m, which could be explained in part by the activity of this object and if the companion is an unresolved multiple system.
46.	Pohl, A., et al. (författare) New constraints on the disk characteristics and companion candidates around T Chamaeleontis with VLT/SPHERE 2017 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 605 Tidskriftsartikel (refereegranskat)abstract Context. The transition disk around the T Tauri star T Cha possesses a large gap, making it a prime target for high-resolution imaging in the context of planet formation.Aims. We aim to find signs of disk evolutionary processes by studying the disk geometry and the dust grain properties at its surface, and to search for companion candidates.Methods. We analyze a set of VLT/SPHERE data at near-infrared and optical wavelengths. We performed polarimetric imaging of T Cha with IRDIS (1.6 mu m) and ZIMPOL (0.5-0.9 mu m), and obtained intensity images from IRDIS dual-band imaging with simultaneous spectro-imaging with IFS (0.9-1.3 mu m).Results. The disk around T Cha is detected in all observing modes and its outer disk is resolved in scattered light with unprecedented angular resolution and signal-to-noise. The images reveal a highly inclined disk with a noticeable east-west brightness asymmetry. The significant amount of non-azimuthal polarization signal in the U-phi images, with a U-phi/Q(phi) peak-to-peak value of 14%, is in accordance with theoretical studies on multiple scattering in an inclined disk. Our optimal axisymmetric radiative transfer model considers two coplanar inner and outer disks, separated by a gap of 0.'' 28 (similar to 30 au) in size, which is larger than previously thought. We derive a disk inclination of similar to 69 deg and PA of similar to 114 deg. In order to self-consistently reproduce the intensity and polarimetric images, the dust grains, responsible for the scattered light, need to be dominated by sizes of around ten microns. A point source is detected at an angular distance of 3.5 '' from the central star. It is, however, found not to be co-moving. Conclusions. We confirm that the dominant source of emission is forward scattered light from the near edge of the outer disk. Our point source analysis rules out the presence of a companion with mass larger than similar to 8.5 M-jup between 0.'' 1 and 0.'' 3. The detection limit decreases to similar to 2 M-jup for 0.'' 3 to 4.0 ''.
47.	Rowcliffe, Eric, 1976, et al. (författare) Demonstration of neutralizing mucosal IgA response to intranasal HIV-1 env DNA vaccines with or without the V3 glycosylation site 2004 Ingår i: Scand J Inf Dis. ; 36, s. 360-364 Tidskriftsartikel (refereegranskat)abstract HIV-1 env based DNA vaccines are generally found to be poor B-cell immunogens. We examined the role of an N-glycan located in the V3 loop of HIV-1 (N306) that is known to modulate the immunogenicity of gp120. Here we describe intranasal immunizations with env (HIV-1 BRU) based genetic immunogens in combination with subcutaneous boosts of recombinant gp160 (rgp160) in mice. Immunization with DNA alone resulted in detectable IgA responses to rgp160 in both faeces and bronchoalveolar lavage (BAL) fluid, but the additional boosting increased the faecal IgA titres only. Protein boosting was required for induction of faecal IgA antibodies capable of neutralizing a homologous laboratory strain and a subtype B primary isolate. The B-cell response towards V3 loop peptides was not only directed against the homologous subtype B but also against the subtype F. In contrast to our previous observations on IgG, there were no differences in anti-gp160 IgA titres elicited by the N-glycan mutant and the wild-type immunogen. These results indicate that intranasal administration of plasmids containing env in combination with a subcutaneous boost proved to be an effective way of eliciting neutralizing mucosal IgA against HIV-1.
48.	Rowcliffe, E, et al. (författare) Demonstration of neutralizing mucosal IgA response to intranasal HIV-1 env DNA vaccines with or without the V3 glycosylation site 2004 Ingår i: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 36:5, s. 360-364 Tidskriftsartikel (refereegranskat)
49.	Samland, M., et al. (författare) Spectral and atmospheric characterization of 51 Eridani b using VLT/SPHERE 2017 Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 603 Tidskriftsartikel (refereegranskat)abstract Context. 51 Eridani b is an exoplanet around a young (20 Myr) nearby (29.4 pc) F0-type star, which was recently discovered by direct imaging. It is one of the closest direct imaging planets in angular and physical separation (similar to 0.5 '', similar to 13 au) and is well suited for spectroscopic analysis using integral field spectrographs. Aims. We aim to refine the atmospheric properties of the known giant planet and to constrain the architecture of the system further by searching for additional companions. Methods. We used the extreme adaptive optics instrument SPHERE at the Very Large Telescope (VLT) to obtain simultaneous dual-band imaging with IRDIS and integral field spectra with IFS, extending the spectral coverage of the planet to the complete Y-to H-band range and providing additional photometry in the K12-bands (2.11, 2.25 mu m). The object is compared to other known cool and peculiar dwarfs. The posterior probability distributions for parameters of cloudy and clear atmospheric models are explored using MCMC. We verified our methods by determining atmospheric parameters for the two benchmark brown dwarfs Gl 570D and HD 3651B. We used archival VLT-NACO (L') Sparse Aperture Masking data to probe the innermost region for additional companions. Results. We present the first spectrophotometric measurements in the Y and K bands for the planet and revise its J-band flux to values 40% fainter than previous measurements. Cloudy models with uniform cloud coverage provide a good match to the data. We derive the temperature, radius, surface gravity, metallicity, and cloud sedimentation parameter f(sed). We find that the atmosphere is highly super-solar ([Fe/H] = 1.0 +/- 0.1 dex), and the low f(sed) = 1.26(-0.29)(+0.36) value is indicative of a vertically extended, optically thick cloud cover with small sized particles. The model radius and surface gravity estimates suggest higher planetary masses of M-gravity = 9.1(-3.3)(+4.9) M-J. The evolutionary model only provides a lower mass limit of > 2 M-J (for pure hot-start). The cold-start model cannot explain the luminosity of the planet. The SPHERE and NACO/SAM detection limits probe the 51 Eri system at solar system scales and exclude brown-dwarf companions more massive than 20 M-J beyond separations of similar to 2.5 au and giant planets more massive than 2 M-J beyond 9 au.
50.	Takahashi, Y., et al. (författare) Weekly somapacitan had no adverse effects on glucose metabolism in adults with growth hormone deficiency 2022 Ingår i: Pituitary. - : Springer Science and Business Media LLC. - 1386-341X .- 1573-7403. Tidskriftsartikel (refereegranskat)abstract Purpose The long-term effects of long-acting growth hormone (LAGH) analogues on glucose metabolism in adult growth hormone deficiency (AGHD) are not known. We investigated the impact of LAGH somapacitan, administered once-weekly, on glucose metabolism in patients with AGHD. Methods In post hoc-defined analyses, we compared the effects of somapacitan with daily growth hormone (GH) and placebo on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-beta) in patients with AGHD across a unique data set from three phase 3 randomized controlled trials (REAL 1, REAL 2 and REAL Japan). Results No new cases of diabetes mellitus were reported with somapacitan. Among GH-naive patients (n = 120 somapacitan, n = 119 daily GH), higher changes from baseline in FPG, HOMA-IR and fasting insulin levels were observed with daily GH versus somapacitan at 34 weeks, but not at 86 weeks. HbA1c and HOMA-beta did not differ between groups at either timepoint. Among treatment-naive patients, sex, age, fasting insulin, glucose tolerance status and body mass index did not influence changes in glucose metabolism. In previously treated patients (REAL 1 extension: n = 51 somapacitan, n = 52 daily GH; REAL 2: n = 61 and n = 31, respectively; REAL Japan: n = 46 and n = 16, respectively), the difference in changes from baseline were not statistically significant between somapacitan and daily GH for any glucose metabolism parameters. Conclusions Somapacitan, compared with daily GH, did not adversely affect glucose metabolism up to 86 weeks in a large cohort of treatment-naive or previously treated patients with AGHD. Trial registrations (date of registration): NCT02229851 (2 September 2014), NCT02382939 (3 March 2015), NCT03075644 (7 March 2017).

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-50 av 51

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (51)

Typ av innehåll: refereegranskat (51)

Författare/redaktör: Janson, Markus (32); Bonnefoy, M. (30); Lagrange, A.-M. (30); Mesa, D. (29); Biller, B. (29); Gratton, R. (28); visa fler...; Chauvin, G. (28); Zurlo, A. (28); Vigan, A. (28); Boccaletti, A. (28); Langlois, M. (27); Desidera, S. (27); Maire, A.-L. (27); Feldt, M. (25); Hagelberg, J. (25); Sissa, E. (23); Perrot, C. (22); Delorme, P. (21); Meyer, M. (20); Bonavita, M. (20); Beuzit, J-L (20); Galicher, R. (19); Henning, T. (18); Ménard, F. (18); Kasper, M (17); Cheetham, A. (17); Ligi, R. (17); Schmidt, T. (16); le Coroller, H (16); D'Orazi, V (16); Wildi, F. (16); Mouillet, D. (16); Peretti, S. (16); Brandner, W. (15); Cantalloube, F. (15); Cudel, M. (14); Lazzoni, C. (14); Ramos, J. (13); Messina, S. (13); Lagadec, E. (12); Samland, M. (12); Lannier, J. (12); Cascone, E. (11); Fantinel, D. (11); Udry, S. (11); Keppler, M. (11); Pavlov, A. (11); Weber, L (11); Girard, J. (11); Fontanive, C. (11); visa färre...

Lärosäte: Stockholms universitet (33); Göteborgs universitet (11); Karolinska Institutet (5); Umeå universitet (2); Lunds universitet (2); Uppsala universitet (1); visa fler...; Örebro universitet (1); Linköpings universitet (1); Chalmers tekniska högskola (1); visa färre...

Språk: Engelska (51)

Forskningsämne (UKÄ/SCB): Naturvetenskap (34); Medicin och hälsovetenskap (13); Teknik (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Stäng

Kopiera och spara länken för att återkomma till aktuell vy