| 1. |
- Aad, G., et al.
(författare)
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Readiness of the ATLAS Tile Calorimeter for LHC collisions
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:4, s. 1193-1236
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Tidskriftsartikel (refereegranskat)abstract
- The Tile hadronic calorimeter of the ATLAS detector has undergone extensive testing in the experimental hall since its installation in late 2005. The readout, control and calibration systems have been fully operational since 2007 and the detector has successfully collected data from the LHC single beams in 2008 and first collisions in 2009. This paper gives an overview of the Tile Calorimeter performance as measured using random triggers, calibration data, data from cosmic ray muons and single beam data. The detector operation status, noise characteristics and performance of the calibration systems are presented, as well as the validation of the timing and energy calibration carried out with minimum ionising cosmic ray muons data. The calibration systems' precision is well below the design value of 1%. The determination of the global energy scale was performed with an uncertainty of 4%.
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| 2. |
- Aad, G., et al.
(författare)
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Studies of the performance of the ATLAS detector using cosmic-ray muons
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:3
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Tidskriftsartikel (refereegranskat)abstract
- Muons from cosmic-ray interactions in the atmosphere provide a high-statistics source of particles that can be used to study the performance and calibration of the ATLAS detector. Cosmic-ray muons can penetrate to the cavern and deposit energy in all detector subsystems. Such events have played an important role in the commissioning of the detector since the start of the installation phase in 2005 and were particularly important for understanding the detector performance in the time prior to the arrival of the first LHC beams. Global cosmic-ray runs were undertaken in both 2008 and 2009 and these data have been used through to the early phases of collision data-taking as a tool for calibration, alignment and detector monitoring. These large datasets have also been used for detector performance studies, including investigations that rely on the combined performance of different subsystems. This paper presents the results of performance studies related to combined tracking, lepton identification and the reconstruction of jets and missing transverse energy. Results are compared to expectations based on a cosmic-ray event generator and a full simulation of the detector response.
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| 3. |
- Aad, G., et al.
(författare)
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The ATLAS Inner Detector commissioning and calibration
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 787-821
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 mu m and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks.
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| 4. |
- Aad, G., et al.
(författare)
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The ATLAS Simulation Infrastructure
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 823-874
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Tidskriftsartikel (refereegranskat)abstract
- The simulation software for the ATLAS Experiment at the Large Hadron Collider is being used for large-scale production of events on the LHC Computing Grid. This simulation requires many components, from the generators that simulate particle collisions, through packages simulating the response of the various detectors and triggers. All of these components come together under the ATLAS simulation infrastructure. In this paper, that infrastructure is discussed, including that supporting the detector description, interfacing the event generation, and combining the GEANT4 simulation of the response of the individual detectors. Also described are the tools allowing the software validation, performance testing, and the validation of the simulated output against known physics processes.
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| 5. |
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| 6. |
- Bengtsson, Kenneth, et al.
(författare)
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Så kan Sverige bli ledande nation i resurseffektivitet
- 2016
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Ingår i: Dagens Nyheter. - 1101-2447. ; :2016-04-30
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Ny rapport. Det svenska näringslivet kan bli mer hållbart, resurssmart och därmed internationellt konkurrenskraftigt. Men för det behövs en tydlig politisk avsiktsförklaring och riktlinjer. Vi har listat sex områden där policyutveckling brådskar, skriver företrädare för näringsliv, forskning och myndigheter i en gemensam uppmaning.
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| 7. |
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| 8. |
- Aad, G., et al.
(författare)
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Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 875-916
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS detector at the Large Hadron Collider has collected several hundred million cosmic ray events during 2008 and 2009. These data were used to commission the Muon Spectrometer and to study the performance of the trigger and tracking chambers, their alignment, the detector control system, the data acquisition and the analysis programs. We present the performance in the relevant parameters that determine the quality of the muon measurement. We discuss the single element efficiency, resolution and noise rates, the calibration method of the detector response and of the alignment system, the track reconstruction efficiency and the momentum measurement. The results show that the detector is close to the design performance and that the Muon Spectrometer is ready to detect muons produced in high energy proton-proton collisions.
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| 9. |
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| 10. |
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| 11. |
- Aad, G., et al.
(författare)
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The ATLAS Experiment at the CERN Large Hadron Collider
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08003
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Forskningsöversikt (refereegranskat)abstract
- The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.
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| 12. |
- Andersson, Erik, et al.
(författare)
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Cost-effectiveness of internet-based cognitive behavior therapy for irritable bowel syndrome: results from a randomized controlled trial
- 2011
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Ingår i: BMC Public Health. - : BioMed Central. - 1471-2458. ; 11:215
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Tidskriftsartikel (refereegranskat)abstract
- Background: Irritable Bowel Syndrome (IBS) is highly prevalent and is associated with a substantial economic burden. Cognitive behavior therapy (CBT) has been shown to be effective in treating IBS. The aim of this study was to evaluate the cost-effectiveness of a new treatment alternative, internet-delivered CBT based on exposure and mindfulness exercises. Methods: Participants (N = 85) with IBS were recruited through self-referral and were assessed via a telephone interview and self-report measures on the internet. Participants were randomized to internet-delivered CBT or to a discussion forum. Economic data was assessed at pre-, post- and at 3-month and 1 year follow-up. Results: Significant cost reductions were found for the treatment group at $16,806 per successfully treated case. The cost reductions were mainly driven by reduced work loss in the treatment group. Results were sustained at 3-month and 1 year follow-up. Conclusions: Internet-delivered CBT appears to generate health gains in IBS treatment and is associated with cost-savings from a societal perspective.
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| 13. |
- Andersson, Erik, et al.
(författare)
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Internet-based cognitive behavior therapy for obsessive compulsive disorder: A pilot study
- 2011
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Ingår i: BMC Psychiatry. - : BioMed Central. - 1471-244X. ; 11:125
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cognitive behavior therapy (CBT) is widely regarded as an effective treatment for obsessive compulsive disorder (OCD), but access to CBT therapists is limited. Internet-based CBT (ICBT) with therapist support is a way to increase access to CBT but has not been developed or tested for OCD. The aim of this study was to evaluate ICBT for OCD. less thanbrgreater than less thanbrgreater thanMethod: An open trial where patients (N = 23) received a 15-week ICBT program with therapist support consisting of psychoeducation, cognitive restructuring and exposure with response prevention. The primary outcome was the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), which was assessed by a psychiatrist before and immediately after treatment. Secondary outcomes were self-rated measures of OCD symptoms, depressive symptoms, general functioning, anxiety and quality of life. All assessments were made at baseline and post-treatment. less thanbrgreater than less thanbrgreater thanResults: All participants completed the primary outcome measure at all assessment points. There were reductions in OCD symptoms with a large within-group effect size (Cohens d = 1.56). At post-treatment, 61% of participants had a clinically significant improvement and 43% no longer fulfilled the diagnostic criteria of OCD. The treatment also resulted in statistically significant improvements in self-rated OCD symptoms, general functioning and depression. less thanbrgreater than less thanbrgreater thanConclusions: ICBT with therapist support reduces OCD symptoms, depressive symptoms and improves general functioning. Randomized trials are needed to confirm the effectiveness of this new treatment format.
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| 14. |
- Andreou, Dimitrios, et al.
(författare)
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Cardiac left ventricular ejection fraction in men and women with schizophrenia on long-term antipsychotic treatment
- 2020
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Ingår i: Schizophrenia Research. - : Elsevier BV. - 0920-9964 .- 1573-2509. ; 218, s. 226-232
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Tidskriftsartikel (refereegranskat)abstract
- Patients with schizophrenia exhibit a higher cardiovascular mortality compared to the general population which has been attributed to life-style factors, genetic susceptibility and antipsychotic medication. Recent echocardiographic studies have pointed to an association between clozapine treatment and reduced left ventricular ejection fraction (LVEF), a measure that has been inversely associated with adverse outcomes including all-cause mortality. Cardiovascular magnetic resonance (CMR) is considered the reference method for LVEF measurement. The aim of the present study was to investigate the LVEF in patients with schizophrenia on long-term treatment with antipsychotics and healthy controls. Twenty-nine adult patients with schizophrenia on long-term medication with antipsychotics and 27 age-, sex- and body mass index-matched healthy controls (mean ages 44 and 45 years, respectively) were recruited from outpatient psychiatric clinics in Uppsala, Sweden. The participants were interviewed and underwent physical examination, biochemical analyses, electrocardiogram and CMR. Men with schizophrenia on long-term antipsychotic treatment showed significantly lower LVEF than controls (p = 0.0076), whereas no such difference was evident among women (p = 0.44). Specifically, clozapine-treated male patients had 10.6% lower LVEF than male controls (p = 0.0064), whereas the LVEF was 5.5% below that of controls among male patients treated with non-clozapine antipsychotics (p = 0.047). Among medicated men with schizophrenia, we found significantly lower LVEF compared to healthy individuals, suggesting the need of routine cardiac monitoring in this patient group. This is the first study showing a significant negative association between treatment with non-clozapine antipsychotics and LVEF.
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| 15. |
- Arvidsson, Björn, et al.
(författare)
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Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.
- 2009
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Ingår i: Journal of chromatography. B. - : Elsevier BV. - 1570-0232 .- 1873-376X. ; 877:3, s. 291-297
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Tidskriftsartikel (refereegranskat)abstract
- This work presents the development and validation of a fully automated quantitative analysis method of melagatran, its prodrug ximelagatran, and its major metabolites for the study of drug behavior in biofluids. The method involves online sample clean-up and enrichment on a C4 capillary column followed by separation on a capillary C18 column. Electrospray ionization tandem mass spectrometric detection in positive ion mode was performed with multiple reactions monitoring of eight different transients, divided into two time segments with four transients each. The structural similarity, the complexity of the matrix (pig liver extract) and the formation of isobaric fragment ions, made efficient chromatographic separation necessary. The analysis method provides valid accuracy (<9%; RSD%), precision (<8%; RSD%), linearity (<1.2 nM–1 μM; R2 > 0.999), limit of quantitation (<3.6 nM), retention repeatability (<1.2%; RSD%), selectivity, as well as analyte and column stabilities over a wide concentration range.
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| 16. |
- Bialik, Erik, et al.
(författare)
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Ionization of Cellobiose in Aqueous Alkali and the Mechanism of Cellulose Dissolution
- 2016
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Ingår i: The Journal of Physical Chemistry Letters. - : American Chemical Society. - 1948-7185. ; 7:24, s. 5044-5048
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Tidskriftsartikel (refereegranskat)abstract
- Cellulose, one of the most abundant renewable resources, is insoluble in most common solvents but dissolves in aqueous alkali under a narrow range of conditions. To elucidate the solubilization mechanism, we performed electrophoretic NMR on cellobiose, a subunit of cellulose, showing that cellobiose acts as an acid with two dissociation steps at pH 12 and 13.5. Chemical shift differences between cellobiose in NaOH and NaCl were estimated using 2D NMR and compared to DFT shift differences upon deprotonation. The dissociation steps are the deprotonation of the hemiacetal OH group and the deprotonation of one of four OH groups on the nonreducing anhydroglucose unit. MD simulations reveal that aggregation is suppressed upon charging cellulose chains in solution. Our findings strongly suggest that cellulose is to a large extent charged in concentrated aqueous alkali, a seemingly crucial factor for solubilization. This insight, overlooked in the current literature, is important for understanding cellulose dissolution and for synthesis of new sustainable materials.
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| 17. |
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| 18. |
- Bäckstrand, Jenny, 1979-, et al.
(författare)
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A method for customer-driven purchasing
- 2013
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Ingår i: Operations Management at the Heart of the Recovery. - : International Annual EurOMA Conference.
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Konferensbidrag (refereegranskat)
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| 19. |
- Cavefors, Oscar, et al.
(författare)
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Regional left ventricular systolic dysfunction associated with critical illness: incidence and effect on outcome
- 2021
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Ingår i: Esc Heart Failure. - : Wiley. - 2055-5822. ; 8:6, s. 5415-5423
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Tidskriftsartikel (refereegranskat)abstract
- Aims Left ventricular (LV) dysfunction can be triggered by non-cardiac disease, such as sepsis, hypoxia, major haemorrhage, or severe stress (Takotsubo syndrome), but its clinical importance is not established. In this study, we evaluate the incidence and impact on mortality of LV dysfunction associated with critical illness. Methods and results In this single-centre, observational study, consecutive patients underwent an echocardiographic examination within 24 h of intensive care unit (ICU) admission. LV systolic dysfunction was defined as an ejection fraction (EF) < 50% and/or regional wall motion abnormalities (RWMA). A cardiologist assessed patients with LV dysfunction for the presence of an acute or chronic cardiac disease, and coronary angiography was performed in high-risk patients. Of the 411 patients included, 100 patients (24%) had LV dysfunction and in 52 (13%) of these patients, LV dysfunction was not attributed to a cardiac disease. Patients with LV dysfunction and non-cardiac disease had higher mortality risk score (Simplified Acute Physiologic Score 3 score), heart rate, noradrenaline doses, and lactate levels as well as decreased EF, stroke volume, and cardiac output compared with patients with normal LV function. Diagnoses most commonly associated with LV dysfunction and non-cardiac disease were sepsis, respiratory insufficiency, major haemorrhage, and neurological disorders. RWMA (n = 40) with or without low EF was more common than global hypokinesia (n = 12) and was reversible in the majority of cases. Twelve patients had a circumferential pattern of RWMA in concordance with Takotsubo syndrome. Crude 30 day mortality was higher in patients with LV dysfunction and non-cardiac disease compared with patients with normal LV function (33% vs. 18%, P = 0.023), but not after risk adjustment (primary outcome) {odds ratio [OR] 1.56 [confidence interval (CI) 0.75-3.39], P = 0.225}. At 90 days, crude mortality was 44% and 22% (P = 0.002), respectively, in these groups. This difference was also significant after risk adjustment [OR 2.40 (CI 1.18-4.88), P = 0.016]. Conclusions Left ventricular systolic dysfunction is commonly triggered by critical illness, is frequently seen as regional hypokinesia, and is linked to an increased risk of death. The prognostic importance of LV dysfunction in critical illness might be underestimated.
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| 20. |
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| 21. |
- Degerman, Erik, et al.
(författare)
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Effekter av kalkning på fisk i rinnande vatten : Resultat från 30 år av elfisken i kalkade vattendrag
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I denna rapport har vi utvärderat effekten av kalkning på fisk i vattendrag på nationell nivå med fokus på perioden 1982–2012. Uppgifter om kalkdoser, kalkningsmetoder, vattenkemi och elfiskedata från 609 vattendrag över hela Sverige har använts. Sammanlagt ingick 1029 elfiskelokaler från kalkade vatten och 195 lokaler från okalkade referensvattendrag (totalt 17 492 elfisketillfällen). Referensvattendragen har utgående från pH och alkalinitet indelats i sura, neutrala och kalkrika. Totalt fångades 38 fiskarter, 2 kräftarter och 2 fiskhybrider vid elfiskena. Den vanligaste arten var öring som erhölls vid 90 % av elfisketillfällena, därefter kom elritsa (33 %) och stensimpa (24 %). Den vattenkemiska effekten har inte utvärderats närmare, men det förelåg en tydlig effekt på pH av kalkning och efter 5-8 års kalkning var lägsta uppmätta pH signifikant över 6,0 som medelvärde för samtliga kalkade vatten. Andelen tillfällen med sura episoder (pH <6,0 respektive pH <5,6) minskade över tid. De vattendrag där det var svårast att upprätthålla pH över 5,6 hade små avrinningsområden (<10 km2), låg andel sjö och en låg kalkdos. Kalkning med doserare uppvisade en högre frekvens av sura episoder jämfört med sjö- och våtmarkskalkning. Efter ett antal år fungerade doserarkalkningen bättre, ofta efter att den kombinerats med våtmarkskalkning. Resultaten från 30 års elfisken visar att kalkningsverksamheten successivt har nått förväntade resultat. Antalet fångade fiskarter ökade signifikant efter kalkstart och efter 13-16 år hade antalet nått nivån i neutrala referenser. På de kalkade lokalerna ökade 13 av 14 undersökta arter i förekomst och 8 av dessa signifikant: abborre, bergsimpa, braxen, gädda, lake, lax, mört och öring. Andel elfisketillfällen med konstaterad reproduktion, dvs. förekomst av årsungar, ökade signifikant efter kalkning och nådde samma nivåer som i neutrala referenser för öring, lax, stensimpa, elritsa, gädda, lake och mört. För öring tog det över 12 år efter kalkstart innan reproduktionen motsvarade den i neutrala referenser. Den ekologiska statusen förbättrades signifikant. Sju år efter påbörjad kalkning uppnåddes en signifikant förändring i ekologisk status och efter tolv år visade medelvärdet för lokalerna på god ekologisk status. Sammantaget visade resultaten på en normalisering av fiskfaunan på kalkade lokaler. Genomgående var fiskfaunan signifikant skild från den i sura referenser och blev med tiden alltmer lik den i neutrala referenser, men var fortfarande klart skild från den i kalkrika referenser. Det var tydligt att återkolonisationen av arter tog lång tid, vilket innebär att kalkningsverksamheten måste vara långsiktig. På lokaler med vattenkemisk provtagning minst fyra gånger under året undersöktes effekten av årets lägsta uppmätta pH på fisk. I neutrala referensvattendrag konstaterades reproduktion av öring vid i medeltal 82,8 % av elfisketillfällena. I kalkade vattendrag ökade andelen tillfällen med öringreproduktion med uppmätt lägsta pH. Ett lägsta pH på 5,6-5,9 låg i underkant för en reproduktion som i neutrala referenser, medan ett lägsta pH på 6,0-6,2 låg i överkant. Även för flera andra arter ökade andelen elfisketillfällen då reproduktion konstaterades med ökat lägsta uppmätta pH, t ex för elritsa, lax och simpor (berg- och stensimpa sammantaget). För elritsa krävdes ett lägsta pH på 6,0-6,2 för att nå reproduktion som i neutrala referenser, för simpor krävdes över 6,2. Ekologisk status är ett index som visar om fiskfaunan liknar den i opåverkade vatten. Medelvärdet för ekologisk status i neutrala referenser var 0,52. På kalkade lokaler där lägsta uppmätta pH under året understeg 6,0 var den ekologiska statusen signifikant lägre än i neutrala referenser. På kalkade lokaler som hade ett uppmätt lägsta pH på minst 6,0 var den ekologiska statusen högre och likvärdig med den i neutrala referenser. Vår slutsats är att i försurade vattendrag innebär ett mål för lägsta pH på 5,6 en betydande risk att en normaliserad fiskfauna inte uppnås. Vi anser att målet för kalkningsverksamheten ska vara en normalisering av flora och fauna och utgående från fisk bör lägsta tillåtna pH därför sättas till minst 6,0.
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| 22. |
- Degerman, Erik, et al.
(författare)
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Long term trends of fish after liming of Swedish streams and lakes
- 2016
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Ingår i: Atmospheric Environment. - : Elsevier BV. - 1352-2310. ; 146, s. 245-251
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Tidskriftsartikel (refereegranskat)abstract
- Thousands of Swedish acidified lakes and streams have been regularly limed for about 30 years. Standard sampling of fish assemblages in lakes and streams was an important part of monitoring the trends after liming, i.e. sampling with multi-mesh gillnets in lakes (EN 14757) and electrofishing in streams (EN 14011). Monitoring data are nationally managed, in the National Register of Survey test-fishing and the Swedish Electrofishing Register. We evaluated long-term data from 1029 electrofishing sites in limed streams and gillnet sampling in 750 limed lakes, along with reference data from 195 stream sites and 101 lakes with no upstream liming in their catchments. The median year of first liming was 1986 for both streams and lakes. The proportion of limed stream sites with no fish clearly decreased with time, mean species richness and proportion of sites with brown trout (Salmo trutta) recruits increased. There were no consistent trends in fish occurrence or species richness at non-limed sites, but occurrence of brown trout recruits also increased in acid as well as neutral reference streams. Abundance of brown trout, perch (Perca fluviatilis) and roach (Rutilus rutilus) increased significantly more at limed sites than at non-limed reference sites sampled before and after 1986. The mean species richness did not change consistently in limed lakes, but decreased in low alkalinity reference lakes, and fish abundance decreased significantly in limed as well as in non-limed lakes.
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| 23. |
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| 24. |
- Edo, Mar, et al.
(författare)
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Assessment of chemical and material contamination in waste wood fuels : a case study ranging over nine years
- 2016
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Ingår i: Waste Management. - : Elsevier. - 0956-053X .- 1879-2456. ; 49, s. 311-319
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Tidskriftsartikel (refereegranskat)abstract
- The increased demand for waste wood (WW) as fuel in Swedish co-combustion facilities during the last years has increased the import of this material. Each country has different laws governing the use of chemicals and therefore the composition of the fuel will likely change when combining WW from different origins. To cope with this, enhanced knowledge is needed on WW composition and the performance of pre-treatment techniques for reduction of its contaminants. In this study, the chemical and physical characteristics of 500 WW samples collected at a co-combustion facility in Sweden between 2004 and 2013 were investigated to determine the variation of contaminant content over time. Multivariate data analysis was used for the interpretation of the data. The concentrations of all the studied contaminants varied widely between sampling occasions, demonstrating the highly variable composition of WW fuels. The efficiency of sieving as a pre-treatment measure to reduce the levels of contaminants was not sufficient, revealing that sieving should be used in combination with other pre-treatment methods. The results from this case study provide knowledge on waste wood composition that may benefit its management. This knowledge can be applied for selection of the most suitable pre-treatments to obtain high quality sustainable WW fuels.
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| 25. |
- Eriksen, Jon, et al.
(författare)
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The Blue Move for a Green Economy : Mulighetsstudie for hydrogen produksjon,industri, lagring og distribusjon
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Blue Move har utarbeidet en rapport som belyser 12 ulike muligheter for produksjon, industri, lagring og distribusjon av hydrogen i ØKS-regionen.Rapporten belyser ogs viktigheten av lav elavgift for hydrogenproduksjon gjennom beregninger gjort for en nyetablert hydrogenstasjon.Interreg-prosjektet Blue Move arbeider for å fremme økt bruk av fornybar energi som erstatning for fossile drivstoff i ØKS-regionen. Mulighetsstudien som er samlet i denne rapporten ser nærmere på hvilke produksjonsmetoder som er mest relevante, relatert til tilgjengelig fornybar kraft. Videre beskriver den hvordan hydrogenet kan anvendes utover veitransport, og på hvilken måte det kan ha betydning for veitransport at det også kommer andre anvendelsesområder.
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| 26. |
- Fredenberg, Erik, PhD, 1979-, et al.
(författare)
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Optimization of mammography with respect to anatomical noise
- 2011
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Ingår i: Medical Imaging 2011. - : SPIE.
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Konferensbidrag (refereegranskat)abstract
- Beam quality optimization in mammography traditionally considers detection of a target obscured by quantum noise on a homogenous background. It can be argued that this scheme does not correspond well to the clinical imaging task because real mammographic images contain a complex superposition of anatomical structures, resulting in anatomical noise that may dominate over quantum noise. Using a newly developed spectral mammography system, we measured the correlation and magnitude of the anatomical noise in a set of mammograms. The results from these measurements were used as input to an observer-model optimization that included quantum noise as well as anatomical noise. We found that, within this framework, the detectability of tumors and microcalcifications behaved very differently with respect to beam quality and dose. The results for small microcalcifications were similar to what traditional optimization methods would yield, which is to be expected since quantum noise dominates over anatomical noise at high spatial frequencies. For larger tumors, however, low-frequency anatomical noise was the limiting factor. Because anatomical structure has similar energy dependence as tumor contrast, optimal x-ray energy was significantly higher and the useful energy region wider than traditional methods suggest. Measurements on a tissue phantom confirmed these theoretical results. Furthermore, since quantum noise constitutes only a small fraction of the noise, the dose could be reduced substantially without sacrificing tumor detectability. Exposure settings used clinically are therefore not necessarily optimal for this imaging task. The impact of these findings on the mammographic imaging task as a whole is, however, at this stage unclear.
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| 27. |
- Gummesson, Anders, 1973, et al.
(författare)
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Relations of Adipose Tissue Cell Death-Inducing DFFA-like Effector A Gene Expression to Basal Metabolic Rate, Energy Restriction and Obesity: Population-based and Dietary Intervention Studies.
- 2007
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 92:12, s. 4759-65
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Tidskriftsartikel (refereegranskat)abstract
- Context: Cell death-inducing DFFA-like effector A (CIDEA) could be a potential target for the treatment of obesity via the modulation of metabolic rate, based on the findings that CIDEA inhibits the brown adipose tissue uncoupling process in rodents. Objective: To investigate the putative link between CIDEA and basal metabolic rate in humans, and to further elucidate the role of CIDEA in human obesity. Design: We have explored CIDEA gene expression in adipose tissue in two different human studies: A cross-sectional and population-based study assessing body composition and metabolic rate (Mölndal Metabolic study, n=92), and a longitudinal intervention-study of obese subjects treated with a very low calorie diet (VLCD study, n=24). Results: The CIDEA gene was predominantly expressed in adipocytes as compared to other human tissues. CIDEA gene expression in adipose tissue was inversely associated with basal metabolic rate independently of body composition, age and gender (p=0.014). VLCD induced an increase in adipose tissue CIDEA expression (p<0.0001) with a subsequent decrease in response to refeeding (p<0.0001). Reduced CIDEA gene expression was associated with a high body fat content (p<0.0001) and with high insulin levels (p<0.01). No dysregulation of CIDEA expression was observed in individuals with the metabolic syndrome when compared with BMI-matched controls. In a separate sample of VLCD-treated subjects (n=10), uncoupling protein 1 expression was reduced during diet (p=0.0026) and inversely associated with CIDEA expression (p=0.0014). Conclusion: The findings are consistent with the concept that CIDEA plays a role in adipose tissue energy expenditure.
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| 28. |
- Gustafsson, Stefan, et al.
(författare)
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Markers of imminent myocardial infarction
- 2024
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Ingår i: Nature Cardiovascular Research. - : Springer Nature. - 2731-0590.
-
Tidskriftsartikel (refereegranskat)abstract
- Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction within 6 months after the baseline blood draw. We analyzed 817 proteins and 1,025 metabolites in biobanked blood and 16 clinical variables. Forty-eight proteins, 43 metabolites, age, sex and systolic blood pressure were associated with the risk of an imminent first myocardial infarction. Brain natriuretic peptide was most consistently associated with the risk of imminent myocardial infarction. Using clinically readily available variables, we devised a prediction model for an imminent first myocardial infarction for clinical use in the general population, with good discriminatory performance and potential for motivating primary prevention efforts.
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| 29. |
- Idström, Alexander, et al.
(författare)
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Dissolution of cellulose in tetrabutylammonium acetate/dimethyl sulfoxide
- 2016
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Ingår i: The 7th Workshop on cellulose, regenerated cellulose and cellulose derivatives. ; , s. 15-18
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The dissolution of cellulose in tetrabutylammonium acetate (TBAAc)/dimethyl sulfoxide (DMSO) was studied combining experimental and simulation techniques. It was found that the dissolution limit at 40 °C corresponded to a molar ratio close to one acetate per cellulose anhydroglucose units. MD simulations suggested that the acetate ions bind to cellulose by dual hydrogen bonds. This effectively turns cellulose into a polyelectrolyte, attracting the bulky tetrabutylammonium (TBA+) counter ions, which prevent close contact between chains in the dissolved state. This hypothesis was tested by 1H- and 13C-NMR spectroscopy, which confirmed that acetate forms hydrogen bonds to cellulose, and by diffusion NMR spectroscopy, which demonstrated a strong dynamic correlation between bound acetate and tetrabutylammonium in near-quantitative agreement with simulation. The present results suggest that offering hydrogen bonding to the acetate ions is the main driving force for dissolving cellulose and that the TBA+ counter ions form a diffuse layer around the acetate-decorated cellulose chains.
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| 30. |
- Idström, Alexander, et al.
(författare)
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On the dissolution of cellulose in tetrabutylammonium acetate/dimethyl sulfoxide : a frustrated solvent
- 2017
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Ingår i: Cellulose. - : Springer Science and Business Media LLC. - 0969-0239 .- 1572-882X. ; 24:9, s. 3645-3657
-
Tidskriftsartikel (refereegranskat)abstract
- We have found that the dissolution of cellulose in the binary mixed solvent tetrabutylammonium acetate/dimethyl sulfoxide follows a previously overlooked near-stoichiometric relationship such that one dissolved acetate ion is able to dissolve an amount of cellulose corresponding to about one glucose residue. The structure and dynamics of the resulting cellulose solutions were investigated using small-angle X-ray scattering (SAXS) and nuclear magnetic resonance techniques as well as molecular dynamics simulation. This yielded a detailed picture of the dissolution mechanism in which acetate ions form hydrogen bonds to cellulose and causes a diffuse solvation sheath of bulky tetrabutylammonium counterions to form. In turn, this leads to a steric repulsion that helps to keep the cellulose chains apart. Structural similarities to previously investigated cellulose solutions in aqueous tetrabutylammonium hydroxide were revealed by SAXS measurement. To what extent this corresponds to similarities in dissolution mechanism is discussed.
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| 31. |
- Johansson, Björn, et al.
(författare)
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Release Rates for Pine Sawfly Pheromones from Two Types of Dispensers and Phenology of Neodiprion sertifer
- 2001
-
Ingår i: Journal of Chemical Ecology. - 0098-0331 .- 1573-1561. ; 27:4, s. 733-745
-
Tidskriftsartikel (refereegranskat)abstract
- Comparisons of release rates, duration in the field, and catch efficiency of polyethylene and cotton roll dispensers for the sex pheromones of sawflies (Hymenoptera: Diprionidae) were conducted. The release rates of the Neodiprion sertifer (Geoffr.) and Diprion pini (L.) sex pheromones, the acetates of pentadecanol and (2S,3S,7S)-3,7-dimethyl (2S,3R,7R)-3,7-dimethyl-2-tridecanol from polyethylene dispensers were measured at different temperatures in the laboratory. The release rates for the substances depended on both the temperature and initial load in the vials. The catch from cotton rolls baited with 100 μg of the acetate or propionate of 3,7-dimethyl-2-pentadecanol was compared to the catch from regularly renewed cotton rolls baited with 10 μg of the same acetate. The catch was higher for the 100-μg cotton rolls for, at most, 45 days, and there was no significant difference in catch between the acetate and the propionate. The catch in traps baited with polyethylene or cotton roll dispensers loaded with the acetate of 3,7-dimethyl-2-pentadecanol was compared and showed that cotton roll traps mirrored the decreasing release of the substance rather than the actual flight activity. The length of the flight period of N. sertifer in Sweden, the Czech Republic, Italy, and Greece did not exceed 100 days in any of the countries. By adjusting the initial pheromone load of the polyethylene vials to the expected temperatures, it should be possible to get a constant and sufficiently high release rate during the entire flight period.
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| 32. |
- Jonsson, Sofi, et al.
(författare)
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Differentiated availability of geochemical mercury pools controls methylmercury levels in estuarine sediment and biota
- 2014
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 4624-
-
Tidskriftsartikel (refereegranskat)abstract
- Neurotoxic methylmercury (MeHg) formed from inorganic divalent mercury (HgII) accumulates in aquatic biota and remains at high levels worldwide. It is poorly understood to what extent different geochemical Hg pools contribute to these levels. Here we report quantitative data on MeHg formation and bioaccumulation, in mesocosm water-sediment model ecosystems, using five HgII and MeHg isotope tracers simulating recent Hg inputs to the water phase and Hg stored in sediment as bound to natural organic matter or as metacinnabar. Calculations for an estuarine ecosystem suggest that the chemical speciation of HgII solid/adsorbed phases control the sediment Hg pool's contribution to MeHg, but that input of MeHg from terrestrial and atmospheric sources bioaccumulates to a substantially greater extent than MeHg formed in situ in sediment. Our findings emphasize the importance of MeHg loadings from catchment runoff to MeHg content in estuarine biota and we suggest that this contribution has been underestimated.
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| 33. |
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| 34. |
- Jonsson, Sofi, 1984-, et al.
(författare)
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Geochemical and Dietary Drivers of Mercury Bioaccumulation in Estuarine Benthic Invertebrates
- 2022
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 56:14, s. 10141-10148
-
Tidskriftsartikel (refereegranskat)abstract
- Sediments represent the main reservoir of mercury (Hg) in aquatic environments and may act as a source of Hg to aquatic food webs. Yet, accumulation routes of Hg from the sediment to benthic organisms are poorly constrained. We studied the bioaccumulation of inorganic and methylmercury (HgII and MeHg, respectively) from different geochemical pools of Hg into four groups of benthic invertebrates (amphipods, polychaetes, chironomids, and bivalves). The study was conducted using mesocosm experiments entailing the use of multiple isotopically enriched Hg tracers and simulation of estuarine systems with brackish water and sediment. We applied different loading regimes of nutrients and terrestrial organic matter and showed that the vertical localization and the chemical speciation of HgII and MeHg in the sediment, in combination with the diet composition of the invertebrates, consistently controlled the bioaccumulation of HgII and MeHg into the benthic organisms. Our results suggest a direct link between the concentration of MeHg in the pelagic planktonic food web and the concentration of MeHg in benthic amphipods and, to some extent, in bivalves. In contrast, the quantity of MeHg in benthic chironomids and polychaetes seems to be driven by MeHg accumulation via the benthic food web. Accounting for these geochemical and dietary drivers of Hg bioaccumulation in benthic invertebrates will be important to understand and predict Hg transfer between the benthic and the pelagic food web, under current and future environmental scenarios.
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| 35. |
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| 36. |
- Jonsson, Sofi, 1984-, et al.
(författare)
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Mercury methylation rates for geochemically relevant HgII species in sediments
- 2012
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 46:21, s. 11653-11659
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Tidskriftsartikel (refereegranskat)abstract
- Monomethylmercury (MeHg) in fish from freshwater, estuarine and marine environments are a major global environmental issue. Mercury levels in biota are mainly controlled by the methylation of inorganic mercuric mercury (HgII) to MeHg in water, sediments and soils. There is, however, a knowledge gap concerning the mechanisms and rates of methylation of specific geochemical HgII species. Such information is crucial for a better understanding of variations in MeHg concentrations among ecosystems and, in particular, for predicting the outcome of currently proposed measures to mitigate mercury emissions and reduce MeHg concentrations in fish. To fill this knowledge gap we propose an experimental approach using HgII isotope tracers, with defined and geochemically important adsorbed and solid HgII forms in sediments, to study MeHg formation. We report HgII methylation rate constants, km, in estuarine sediments which span over two orders of magnitude depending on chemical form of added tracer: metacinnabar (β-201HgS(s)) < cinnabar (α-199HgS(s)) < HgII reacted with mackinawite (≡FeS-202HgII) < HgII bonded to natural organic matter (NOM-196HgII) < a typical aqueous tracer (198Hg(NO3)2(aq)). We conclude that a combination of thermodynamic and kinetic effects of HgII solid-phase dissolution and surface desorption control the HgII methylation rate in sediments and causes the large observed differences in km-values. The selection of relevant solid-phase and surface adsorbed HgII tracers will therefore be crucial to achieving biogeochemically accurate estimates of ambient HgII methylation rates.
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| 37. |
- Jonsson, Sofi, et al.
(författare)
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Terrestrial discharges mediate trophic shifts and enhance methylmercury accumulation in estuarine biota
- 2017
-
Ingår i: Science Advances. - : American association for the advancement of science. - 2375-2548. ; 3:1
-
Tidskriftsartikel (refereegranskat)abstract
- The input of mercury (Hg) to ecosystems is estimated to have increased two- to fivefold during the industrial era, and Hg accumulates in aquatic biota as neurotoxic methylmercury (MeHg). Escalating anthropogenic land use and climate change are expected to alter the input rates of terrestrial natural organic matter (NOM) and nutrients to aquatic ecosystems. For example, climate change has been projected to induce 10 to 50% runoff increases for large coastal regions globally. A major knowledge gap is the potential effects on MeHg exposure to biota following these ecosystem changes. We monitored the fate of five enriched Hg isotope tracers added to mesocosm scale estuarine model ecosystems subjected to varying loading rates of nutrients and terrestrial NOM. We demonstrate that increased terrestrial NOM input to the pelagic zone can enhance the MeHg bioaccumulation factor in zooplankton by a factor of 2 to 7 by inducing a shift in the pelagic food web from autotrophic to heterotrophic. The terrestrial NOM input also enhanced the retention of MeHg in the water column by up to a factor of 2, resulting in further increased MeHg exposure to pelagic biota. Using mercury mass balance calculations, we predict that MeHg concentration in zooplankton can increase by a factor of 3 to 6 in coastal areas following scenarios with 15 to 30% increased terrestrial runoff. The results demonstrate the importance of incorporating the impact of climate-induced changes in food web structure on MeHg bioaccumulation in future biogeochemical cycling models and risk assessments of Hg.
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| 38. |
- Jonsson, Sofi, 1984-
(författare)
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Unraveling the importance of solid and adsorbed phase mercury speciation for methylmercury formation, evasion and bioaccumulation
- 2013
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Monomethylmercury, MeHg, is formed under anoxic conditions in waters, sediments and soils and then bioaccumulated and biomagnified in aquatic food webs, negatively effecting both human and wildlife health. It is generally accepted that precipitation of mercury, Hg, and adsorption of Hg to e.g. organic matter and mineral surfaces are important processes limiting the reactivity of Hg mobilized in the environment by natural and anthropogenic activities. However, knowledge concerning the role of different solid and adsorbed chemical forms of Hg for MeHg formation, evasion and bioaccumulation is missing. Such information is vital for the understanding of environmental processes controlling MeHg formation and bioaccumulation, as well as for predicting how changes in e.g. loading rates of atmospheric Hg and the outcome of climate change scenarios and anthropogenic land use could alter Hg concentrations in biota.In this thesis, a novel experimental approach, using isotopically enriched solid and adsorbed phases of inorganic Hg, HgII, as tracers, was developed. Using this approach, we successfully determined rates of MeHg formation from solid and adsorbed Hg species in sediment slurries and in mesocosm systems under conditions closely resembling those in field. We conclude that the solid/adsorbed phase speciation of HgII is a major controlling factor for MeHg net formation rates. Microcosm experiments revealed that newly formed MeHg was a major contributor to the evasion of MeHg from the water‒sediment system, emphasizing the importance of MeHg formation rate, rather than MeHg concentration, in the sediment for this process. From mesocosm systems, we provide experimental evidence, as well as quantitate data, for that terrestrial and atmospheric sources of HgII and MeHg are more available for methylation and bioaccumulation processes than HgII and MeHg stored and formed in sediments. This suggests that the contribution from terrestrial and atmospheric sources to the accumulation of Hg in fish may have been underestimated. As a consequence, in regions where climate change is expected to further increase land runoff, terrestrial MeHg sources may have even higher negative effects on biota than previously thought. Data and concepts presented in this thesis lay the basis for unprecedented in-depth modeling of processes in the Hg biogeochemical cycle that will improve our understanding and the predicting power on how aquatic ecosystems may respond to environmental changes or differences in loading rates for atmospheric Hg.
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| 39. |
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| 40. |
- Källhammer, Jan-Erik, et al.
(författare)
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Near Zone Pedestrian Detection using a Low-Resolution FIR Sensor
- 2007
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Ingår i: Intelligent Vehicles Symposium, 2007 IEEE. - Istanbul, Turkey : IEEE. - 1424410673
-
Konferensbidrag (refereegranskat)abstract
- This paper explores the possibility to use a single low-resolution FIR camera for detection of pedestrians in the near zone in front of a vehicle. A low resolution sensor reduces the cost of the system, as well as the amount of data that needs to be processed in each frame.We present a system that makes use of hot-spots and image positions of a near constant bearing to detect potential pedestrians. These detections provide seeds for an energy minimization algorithm that fits a pedestrian model to the detection. Since false alarms are hard to tolerate, the pedestrian model is then tracked, and the distance-to-collision (DTC) is measured by integrating size change measurements at sub-pixel accuracy, and the car velocity. The system should only engage braking for detections on a collision course, with a reliably measured DTC.Preliminary experiments on a number of recorded near collision sequences indicate that our method may be useful for ranges up to about 10m using an 80x60 sensor, and somewhat more using a 160x120 sensor. We also analyze the robustness of the evaluated algorithm with respect to dead pixels, a potential problem for low-resolution sensors.
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| 41. |
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| 42. |
- Lagerstedt, Marianne, 1967-
(författare)
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Mot nätverkssjukvård i komplex miljö : - behov av en vetenskaplig syn på ledning för säker vård och effektiv resursanvändning
- 2016
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Since 2008 advanced home healthcare agencies (ASiH) in a larger Swedish county council has underwent a transformation, to become part of a coming concept: networked healthcare (NVS). NVS means that intermediate multi-organizational healthcare (IMV) will be produced often in the home, and from 2013 to an increasing number of patients in different age groups with different diagnoses and medical conditions - in large variability of needs. At the same time IMV has proved to be not simply practical to implement in a resource-efficient and patientsafe way. Based on theories from Command and Control Science the safetyproblem that arise in connection with IMV is a sign of the less known increasing need of the direction and coordination support that IMV requires.With a casestudy based research approach with interactive elements, different qualitative methods has been used in two phases between 2008 - 2013. The first phase is characterized by a phenomenological approach, while the second phase has a critical hermeneutic approach. Research methods includes fieldvisits with informal discussions, in-depth interviews, validation with respondents and two different methodologies for textanalysis.The main result shows that practical aggravating circumstances for safe care consists of lesser known and from 2013 increasing problems with direction and coordination, through expanded advanced IMV in the home as a part of NVS concept. This also as a result of inadequate and inappropriate direction and coordination support for IMV.The thesis concludes that the NVS represents a resource intensive health care concept, which requires a new view on the management issue and a network-related methodology for direction and coordination. This is to promote ethical, equitable, patientsafe and dignified advanced IMV so an optimized use of resources can be implemented, through shared responsibility and coordination in patientuniquely designed networkconstellations as a given work model.
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| 43. |
- Larsson, Tom, et al.
(författare)
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Studies of transport and collection characteristics of gaseous mercury in natural gases using amalgamation and isotope dilution analysis
- 2007
-
Ingår i: The Analyst. - : RSC Publishing. - 0003-2654 .- 1364-5528. ; 132:6, s. 579-586
-
Tidskriftsartikel (refereegranskat)abstract
- Transport and collection characteristics were studied for gaseous elemental mercury (Hg0(g)) in natural gases using newly developed methodology based on amalgamation, isotope dilution with permeation tubes and inductively coupled plasma mass spectrometry. The study involved different Au–Pt collection tube designs, tubing materials and gaseous matrices, including air, natural and sales gas, as well as methane and sales gas to which hydrogen sulfide (H2S) had been added. The Hg0(g) capacity of the Au–Pt tubes was determined to 3.5 ± 0.1 µg. Blanks and detection limits of gaseous mercury (Hg(g)) were 58 ± 17 pg m–3 and 50 pg m–3, respectively, for a 60 L sample volume. For the gases tested, added Hg0(g) tracers could be collected with 90% or higher efficiency at flow rates and volumes of up to 10 L min–1 and 100 L, respectively. The collection efficiency was found to be independent of the type of gas tested, even in the presence of H2S. However, for the gases containing H2S, the apparent transport efficiency of added Hg0(g) tracers through stainless steel tubing varied from 50 to 150% upon changing the temperature from 25 to 100 °C. The interaction of stainless steel with Hg0(g) leading to either a sink, or source of Hg, was not observed in the absence of H2S, nor was it observed for PTFE tubing in the presence of H2S. These observations raise questions about the applicability of currently used sampling procedures for determination of Hg(g) in H2S rich natural gases, including the 6978-2 ISO standard method, in which stainless steel is a prescribed material for tubing and valves of the sampling apparatus.
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| 44. |
- Liem-Nguyen, Van, et al.
(författare)
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Effects of Nutrient Loading and Mercury Chemical Speciation on the Formation and Degradation of Methylmercury in Estuarine Sediment
- 2016
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 50:13, s. 6983-6990
-
Tidskriftsartikel (refereegranskat)abstract
- Net formation of methylmercury (MeHg) in sediments is known to be affected by the availability of inorganic divalent mercury (HgII) and by the activities of HgII methylating and MeHg demethylating bacteria. Enhanced autochthonous organic matter deposition to the benthic zone, following increased loading of nutrients to the pelagic zone, has been suggested to increase the activity of HgII methylating bacteria and thus the rate of net methylation. However, the impact of increased nutrient loading on the biogeochemistry of mercury (Hg) is challenging to predict as different geochemical pools of Hg may respond differently to enhanced bacterial activities. Here, we investigate the combined effects of nutrient (N and P) supply to the pelagic zone and the chemical speciation of HgII and of MeHg on MeHg formation and degradation in a brackish sediment-water mesocosm model ecosystem. By use of Hg isotope tracers added in situ to the mesocosms or ex situ in incubation experiments, we show that the MeHg formation rate increased with nutrient loading only for HgII tracers with a high availability for methylation. Tracers with low availability did not respond significantly to nutrient loading. Thus, both microbial activity (stimulated indirectly through plankton biomass production by nutrient loading) and HgII chemical speciation were found to control the MeHg formation rate in marine sediments.
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| 45. |
- Lindgren, Erik, 1981-
(författare)
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One coin - One vote : the rural political power shift that pushed Sweden towards industrialization
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Causal Effect of Political Power on the Provision of Public Education: Evidence from a Weighted Voting SystemWe estimate how political power affects the provision of public education in local governments, using data from a nondemocratic society where voters received votes in proportion to their taxable income. This was the system used in Swedish local governments during the period 1862–1909. We use two different identification strategies, a threshold regression analysis and a generalized event-study design, both of which exploit nonlinearities or discontinuities in the effect of political power between two opposing local elites: agricultural landowners and emerging industrialists. The results suggest that school spending is approximately 90–120% higher if the non-agrarian interest controls all of the votes compared to when landowners have a majority.The Causal Effect of Transport Infrastructure: Evidence from a New Historical DatabaseWe analyze the effect of railroad investments on economic growth and find large effects of having access to railways. For real non-agricultural income, the cumulative treatment effect is approximately 130% after 30 years. We also show that the effect is likely to reflect growth rather than a reorganization of existing economic activity since no spillover effects between treated and untreated regions are found. Our results are consistent with the big push hypothesis that argues that simultaneous and coordinated investment can generate economic growth if there are strong aggregate demand externalities. We corroborate this mechanism by using plant-level data and find that investments in local railways significantly increase local industrial production and employment.The Political Economics of Growth, Labor Control and Coercion: Evidence from a Suffrage Reform Here we analyze the breadth of Sweden’s industrial, economic and social development from the 1860s to the 1910s. By using a novel constructed historical dataset of approximately 2,400 Swedish local governments we find that the change in suffrage affected several outcomes at the local level. These outcomes include factor price manipulation in the form of entry barriers such as investments in local public education and transportation; technology adoption and labor productivity in agriculture and industry; changes in the real wage structure, composition of employment, and the structure of production; organized labor and labor coercion; demographic transition; and persistence in dysfunctional local political institutions. Our results support the idea that political institutions are a key determinant of long-term development and growth. Precipitation and Infant Mortality: Evidence from Sweden 1881–1950I analyze the dynamic effects of precipitation on infant mortality, using a panel dataset containing monthly mortality data from approximately 2,150 Swedish parishes and monthly precipitation levels collected at a number of weather stations around the country. Given that I use data from 1881 to 1950, the size of this novel panel dataset is considerable. Parishes have been matched to the closest weather station for every given month. Given that precipitation, is neither binary nor constant, a binned event-study design is used to estimate the dynamic effects with respect to the precipitation intensity. The results show that increased precipitation decreases infant mortality for both male and female infants. The dynamic effect after 4 months is about 8 percent.
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| 46. |
- Löwhagen Hendén, Pia, et al.
(författare)
-
Hypotension During Endovascular Treatment of Ischemic Stroke Is a Risk Factor for Poor Neurological Outcome.
- 2015
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Ingår i: Stroke; a journal of cerebral circulation. - 1524-4628. ; 46:9, s. 2678-2680
-
Tidskriftsartikel (refereegranskat)abstract
- In retrospective studies, patients receiving general anesthesia for endovascular treatment for acute ischemic stroke have worse neurological outcome compared with patients receiving conscious sedation. It has been suggested that this is caused by general anesthesia-associated hypotension. We investigated the effect of intraprocedural hypotension on neurological outcome.
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| 47. |
- Michaëlsson, Erik, et al.
(författare)
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Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.
- 2023
-
Ingår i: JACC. Heart failure. - 2213-1787. ; 11:7, s. 775-87
-
Tidskriftsartikel (refereegranskat)abstract
- Systemic microvascular dysfunction and inflammation are postulated to play a pathophysiologic role in heart failure with preserved ejection fraction (HFpEF).This study aimed to identify biomarker profiles associated with clinical outcomes in HFpEF and investigate how inhibition of the neutrophil-derived reactive oxygen species-producing enzyme, myeloperoxidase, affects these biomarkers.Using supervised principal component analyses, the investigators assessed the associations between baseline plasma proteomic Olink biomarkers and clinical outcomes in 3 independent observational HFpEF cohorts (n=86, n=216, and n=242). These profiles were then compared with the biomarker profiles discriminating patients treated with active drug vs placebo in SATELLITE (Safety and Tolerability Study of AZD4831 in Patients With HeartFailure), a double-blind randomized 3-month trial evaluating safety and tolerability of the myeloperoxidase inhibitor AZD4831 in HFpEF (n=41). Pathophysiological pathways were inferred from the biomarker profiles by interrogation of the Ingenuity Knowledge database.TNF-R1, TRAIL-R2, GDF15, U-PAR, and ADM were the top individual biomarkers associated with heart failure hospitalization or death, and FABP4, HGF, RARRES2, CSTB, and FGF23 were associated with lower functional capacity and poorer quality of life. AZD4831 downregulated many markers (most significantly CDCP1, PRELP, CX3CL1, LIFR, VSIG2). There was remarkable consistency among pathways associated with clinical outcomes in the observational HFpEF cohorts, the top canonical pathways being associated with tumor microenvironments, wound healing signaling, and cardiac hypertrophy signaling. These pathways were predicted to be downregulated in AZD4831 relative to placebo-treated patients.Biomarker pathways that were most strongly associated with clinical outcomes were also the ones reduced by AZD4831. These results support the further investigation of myeloperoxidase inhibition in HFpEF.
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| 48. |
- Mold, Jeff E., et al.
(författare)
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Divergent clonal differentiation trajectories establish CD8(+) memory T cell heterogeneity during acute viral infections in humans
- 2021
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 35:8
-
Tidskriftsartikel (refereegranskat)abstract
- The CD8(+) T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells. How individual T cell clones contribute to this heterogeneity throughout immune responses remains largely unknown. In this study, we longitudinally track human CD8(+) T cell clones expanding in response to yellow fever virus (YFV) vaccination at the single-cell level. We observed a drop in clonal diversity in blood from the acute to memory phase, suggesting that clonal selection shapes the circulating memory repertoire. Clones in the memory phase display biased differentiation trajectories along a gradient from stem cell to terminally differentiated effector memory fates. In secondary responses, YFV- and influenza-specific CD8(+) T cell clones are poised to recapitulate skewed differentiation trajectories. Collectively, we show that the sum of distinct clonal phenotypes results in the multifaceted human T cell response to acute viral infections.
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| 49. |
- Morén, Björn, 1987-, et al.
(författare)
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Technical note: evaluation of a spatial optimization model for prostate high dose‐rate brachytherapy in a clinical treatment planning system
- 2023
-
Ingår i: Medical physics (Lancaster). - : WILEY. - 0094-2405 .- 2473-4209. ; 50:2, s. 688-693
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundSpatial properties of a dose distribution, such as volumes of contiguous hot spots, are of clinical importance in treatment planning for high dose-rate brachytherapy (HDR BT). We have in an earlier study developed an optimization model that reduces the prevalence of contiguous hot spots by modifying a tentative treatment plan. PurposeThe aim of this study is to incorporate the correction of hot spots in a standard inverse planning workflow and to validate the integrated model in a clinical treatment planning system. The spatial function is included in the objective function for the inverse planning, as opposed to in the previous study where it was applied as a separate post-processing step. Our aim is to demonstrate that fine-adjustments of dose distributions, which are often performed manually in todays clinical practice, can be automated. MethodsA spatial optimization function was introduced in the treatment planning system RayStation (RaySearch Laboratories AB, Stockholm, Sweden) via a research interface. A series of 10 consecutive prostate patients treated with HDR BT was retrospectively replanned with and without the spatial function. ResultsOptimization with the spatial function decreased the volume of the largest contiguous hot spot by on average 31%, compared to if the function was not included. The volume receiving at least 200% of the prescription dose decreased by on average 11%. Target coverage, measured as the fractions of the clinical target volume (CTV) and the planning target volume (PTV) receiving at least the prescription dose, was virtually unchanged (less than a percent change for both metrics). Organs-at-risk received comparable or slightly decreased doses if the spatial function was included in the optimization model. ConclusionsOptimization of spatial properties such as the volume of contiguous hot spots can be integrated in a standard inverse planning workflow for brachytherapy, and need not be conducted as a separate post-processing step.
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| 50. |
- Mowlér, Marc, et al.
(författare)
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Joint estimation of mutual coupling, element factor, and phase center in antenna arrays
- 2007
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Ingår i: EURASIP Journal on Wireless Communications and Networking. - : Springer Science and Business Media LLC. - 1687-1472 .- 1687-1499. ; 2007:1, s. 030684-
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Tidskriftsartikel (refereegranskat)abstract
- A novel method is proposed for estimation of the mutual coupling matrix of an antenna array. The method extends previous work by incorporating an unknown phase center and the element factor (antenna radiation pattern) in the model, and treating them as nuisance parameters during the estimation of coupling. To facilitate this, a parametrization of the element factor based on a truncated Fourier series is proposed. The performance of the proposed estimator is illustrated and compared to other methods using data from simulations and measurements, respectively. The Cramer-Rao bound (CRB) for the estimation problem is derived and used to analyze how the required amount of measurement data increases when introducing additional degrees of freedom in the element factor model. We find that the penalty in SNR is 2.5 dB when introducing a model with two degrees of freedom relative to having zero degrees of freedom. Finally, the tradeoff between the number of degrees of freedom and the accuracy of the estimate is studied. A linear array is treated in more detail and the analysis provides a specific design tradeoff.
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