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- Johansson, Karin, et al.
(författare)
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Two-year follow-up of temporal changes of breast edema after breast cancer treatment with surgery and radiation evaluated by tissue dielectric constant (TDC)
- 2015
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Ingår i: European Journal of Lymphology and Related Problems. - 0778-5569. ; 27:73, s. 15-21
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Tidskriftsartikel (refereegranskat)abstract
- Background: Breast edema is reported as a common complaint after breast conserving surgery and radiotherapy (RT). Measurements of local water in skin and upper subeutis with tissue dielectric constant (TDC) technique have the potential to detect breast edema in patients after breast cancer treatment. Objective: The purpose of the present study was to examine development of edema in breast, axilla and upper arm in women treated with breast conserving surgery and RT during a 2-year follow-up. Method: Sixty-five patients have been included and measured at It) time-points (before RT. three time-points during RT. 2 and 4 weeks after RT and then 3.6, 12 and 24 months after RT). Breast edema was measured by tissue water content in skin and upper subcutis at both sides with MoistureMeterD. TDC. directly proportional to tissue water content to the effective depth of 2.5 mm. was evaluated. Definition of breast edema was determined as a TDC ratio 1.40 between Ihe treated and healthy breast. Results: The TDC measurements demonstrated breast edema already before RT. The mean TDC ratios at three weeks of RT and at 3 and 6 months post-RT were exceeding the edema threshold limit (i.e. TDC ratio l .40). The largest proportions of patients exceeding the edema threshold limit were found at three and six month post-RT (63%) and the smallest proportions at two years post-RT (28%). Concerning axillary dissection or sentinel node biopsy, no statistically significant differences were found between the groups at any of the 10 different measurement time-points. Conclusion: Cancer treatment related edema in the breast is very frequent at three to six months after RT but decreases at one to two years after RT. Differences in the surgical procedure are unlikely to change the incidence of breast edema during a two-year follow- up period.
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| 2. |
- Nyqvist, Johanna, et al.
(författare)
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Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up
- 2016
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Ingår i: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 118:2, s. 335-341
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer. Material and methods: 750 patients with squamous cell carcinoma (of any grade and stage) in the oral cavity, oro-, or hypopharynx or larynx (except T1-2, NO glottic carcinoma) without distant metastases were randomised to either conventional fractionation (2 Gy/day, 5 days/week in 49 days, total dose 68 Gy) or accelerated fractionation (1.1 + 2.0 Gy/day, 5 days/week in 35 days, total dose 68 Gy). HRQoL was assessed with EORTC QLQ-C30, QLQ-H&N35 and HADS at baseline, at end of radiotherapy (eRT) and at 3 and 6 months and 1, 2 and 5 years after start of treatment. Results: The AF group reported HRQoL was significantly lower at eRT and at 3 months for most symptoms, scales and functions. Few significant differences were noted between the groups at 6 months and 5 years. Scores related to functional oral intake never reached baseline. Conclusion: In comparison to CF, AF has a stronger adverse effect on HRQoL in the acute phase.
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