| 1. |
- Feroci, M., et al.
(författare)
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The large observatory for x-ray timing
- 2014
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 9780819496126
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Konferensbidrag (refereegranskat)abstract
- The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.
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| 2. |
- Feroci, M., et al.
(författare)
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LOFT - The large observatory for x-ray timing
- 2012
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE - International Society for Optical Engineering. - 9780819491442 ; , s. 84432D-
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Konferensbidrag (refereegranskat)abstract
- The LOFT mission concept is one of four candidates selected by ESA for the M3 launch opportunity as Medium Size missions of the Cosmic Vision programme. The launch window is currently planned for between 2022 and 2024. LOFT is designed to exploit the diagnostics of rapid X-ray flux and spectral variability that directly probe the motion of matter down to distances very close to black holes and neutron stars, as well as the physical state of ultradense matter. These primary science goals will be addressed by a payload composed of a Large Area Detector (LAD) and a Wide Field Monitor (WFM). The LAD is a collimated (<1 degree field of view) experiment operating in the energy range 2-50 keV, with a 10 m2 peak effective area and an energy resolution of 260 eV at 6 keV. The WFM will operate in the same energy range as the LAD, enabling simultaneous monitoring of a few-steradian wide field of view, with an angular resolution of <5 arcmin. The LAD and WFM experiments will allow us to investigate variability from submillisecond QPO's to yearlong transient outbursts. In this paper we report the current status of the project.
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| 3. |
- Dunn, R. J. H., et al.
(författare)
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GLOBAL CLIMATE : State of the Climate in 2020
- 2021
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Ingår i: Bulletin of the American Meteorological Society. - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 102:8
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Bodin, Fernando, 1991, et al.
(författare)
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The Association of Cigarette Smoking With High-Frequency Heart Rate Variability: An Ecological Momentary Assessment Study
- 2017
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Ingår i: Psychosomatic Medicine. - : Ovid Technologies (Wolters Kluwer Health). - 0033-3174 .- 1534-7796. ; 79:9, s. 1045-1050
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Tidskriftsartikel (refereegranskat)abstract
- Objective Evidence from both laboratory and observational studies suggests that acute and chronic smoking leads to reduced high-frequency heart rate variability (HF-HRV), a measure of cardiac vagal regulation. We used ecological momentary assessment (EMA) to study the effect of smoking on concurrent HF-HRV in a trial measuring the effects of hostility reduction and compared 24-hour HF-HRV in smokers and nonsmokers. Method Ambulatory electrocardiogram data were collected before randomization from 149 healthy individuals with high hostility levels (20-45 years, body mass index 32 kg/m(2)) and paired with concurrent EMA ratings of smoking and physical position during waking hours. A multilevel mixed model was estimated associating ln(HF-HRV) from smoking status (between-person factor) and person-centered momentary smoking (within-person factor, treated as a random effect), adjusting for momentary physical position, medication use, and consumption of alcohol and caffeine. Results Thirty-five smokers and 114 nonsmokers provided both EMA and HF-HRV data. Within smokers, ln HF-HRV was reduced by 0.31 millisecond(2) (p = .04) when participants reported having recently smoked cigarettes, compared with when they had not. The 24-hour HF-HRV was significantly lower in smokers (M [SD] = 5.24 [0.14] milliseconds(2)) than nonsmokers (5.63 0.07 milliseconds(2), p = .01). Conclusions In healthy smokers with high hostility levels used as their own controls during daily living, smoking acutely reduced HF-HRV. HF-HRV was also reduced in smokers as compared with nonsmokers. Although limited by a small sample of individuals with high hostility levels, these findings nonetheless provide additional evidence that cardiac vagal regulation is lowered by cigarette smoking, which may be one of the numerous pathophysiological effects of smoking.
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| 5. |
- Perri, M, et al.
(författare)
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Precarious work on the rise
- 2024
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Ingår i: BMC public health. - 1471-2458. ; 24:1, s. 2074-
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Tidskriftsartikel (refereegranskat)
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| 6. |
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| 7. |
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| 8. |
- Bodin, Örjan, et al.
(författare)
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Improving network approaches to the study of complex social–ecological interdependencies
- 2019
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Ingår i: Nature Sustainability. - : Springer Science and Business Media LLC. - 2398-9629. ; 2:7, s. 551-559
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Tidskriftsartikel (refereegranskat)abstract
- Achieving effective, sustainable environmental governance requires a better understanding of the causes and consequences of the complex patterns of interdependencies connecting people and ecosystems within and across scales. Network approaches for conceptualizing and analysing these interdependencies offer one promising solution. Here, we present two advances we argue are needed to further this area of research: (i) a typology of causal assumptions explicating the causal aims of any given network-centric study of social–ecological interdependencies; (ii) unifying research design considerations that facilitate conceptualizing exactly what is interdependent, through what types of relationships and in relation to what kinds of environmental problems. The latter builds on the appreciation that many environmental problems draw from a set of core challenges that re-occur across contexts. We demonstrate how these advances combine into a comparative heuristic that facilitates leveraging case-specific findings of social–ecological interdependencies to generalizable, yet context-sensitive, theories based on explicit assumptions of causal relationships.
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| 9. |
- Gustavsson, P., et al.
(författare)
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Time trends in occupational exposure to chemicals in Sweden: proportion exposed, distribution across demographic and labor market strata, and exposure levels
- 2022
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 48:6, s. 479-489
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Tidskriftsartikel (refereegranskat)abstract
- Objective This study investigated time trends in occupational exposure to various chemicals in Sweden and the distribution across demographic and labor market sectors. Methods Exposure to six chemicals was investigated from 1980 to 2013 by application of a job exposure matrix to national population registers. Respirable crystalline silica (RCS), diesel engine exhaust, welding fumes, wood dust, chlorinated hydrocarbon solvents, and lead were selected to represent different groups of chemicals. Trends in exposure prevalence were investigated by linear regression and compared to the occupationally active popula-tion. Confidence intervals for the rate of change over time were obtained by bootstrapping. Results The proportion of workers born outside the Nordic countries increased over time in those exposed to RCS, diesel exhaust and wood dust. There was a shift of exposed jobs to small companies (<50 employees), especially for RCS, welding fumes, wood dust, and chlorinated hydrocarbon solvents. For RCS and welding fumes, there was a marked drop in exposure levels from 1980 to 1990 but small changes thereafter. Exposure to lead diminished, both in terms of prevalence and intensity. Conclusions Over time, several exposures tended to shift to small companies, the construction sector, and migrant workers, all factors being indicative of less well-controlled working conditions. Occupational exposure to chlorinated organic solvents and lead diminished, while exposure levels to RCS and welding fumes have changed little since 1990. In view of the serious and well-established negative health effects, increased efforts to reduce exposure to RCS and welding fumes are needed.
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| 10. |
- Janssen, M A, et al.
(författare)
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Toward a network perspective of the study of resilience in social-ecological systems
- 2006
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Ingår i: Ecology and Society. - : Resilience Alliance, Inc.. - 1708-3087. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Formal models used to study the resilience of social-ecological systems have not explicitly included important structural characteristics of this type of system. In this paper, we propose a network perspective for social-ecological systems that enables us to better focus on the structure of interactions between identifiable components of the system. This network perspective might be useful for developing formal models and comparing case studies of social-ecological systems. Based on an analysis of the case studies in this special issue, we identify three types of social-ecological networks: ( 1) ecosystems that are connected by people through flows of information or materials, ( 2) ecosystem networks that are disconnected and fragmented by the actions of people, and ( 3) artificial ecological networks created by people, such as irrigation systems. Each of these three archytypal social-ecological networks faces different problems that influence its resilience as it responds to the addition or removal of connections that affect its coordination or the diffusion of system attributes such as information or disease.
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| 11. |
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| 12. |
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| 13. |
- Porto, G., et al.
(författare)
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Thermodynamic and thermoelastic properties of hypostoichiometric MOX fuels with molecular dynamics simulations
- 2024
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 598
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Tidskriftsartikel (refereegranskat)abstract
- Employing the Cooper-Rushton-Grimes (CRG) interatomic empirical potential with new parameters for U3+ interactions in U1-y,PuyO2-x, classical Molecular Dynamics simulations were carried out for the first time to compute the enthalpy, the lattice parameter, the elastic constants and derived properties of hypostoichiometric U1-y,PuyO2-x compounds (with y in the range 0-1, x between 1.92-2.0, and from 1000 K to melting points). As hypostoichiometry results from adding oxygen vacancies to U1-y,PuyO2, this study investigates how oxygen vacancies affect the thermodynamic and thermomechanical properties of MOX compounds. The most pronounced effect appears at high temperatures, where the so-called Bredig transition occurs. We observed that the effects of this transition on the properties are softened by the presence of oxygen vacancies. The analytical law of the heat capacity for stoichiometric mixed-oxide fuels U1-y,PuyO2 developed by Bathellier et al. [9] was modified by introducing the deviation from stoichiometry as a variable. It was fitted on Molecular Dynamics data of heat capacity and linear thermal expansion coefficient and a good agreement was found. To model the thermal evolution of mechanical properties up to the melting point, a new law was developed. The laws may be used in Fuel Performance Codes.
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| 14. |
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| 15. |
- Alexander, Steven M., et al.
(författare)
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Social ties explain catch portfolios of small-scale fishers in the Caribbean
- 2020
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Ingår i: Fish and Fisheries. - : Wiley. - 1467-2960 .- 1467-2979. ; 21:1, s. 120-131
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Tidskriftsartikel (refereegranskat)abstract
- Small-scale fisheries often involve weak management regimes with limited top-down enforcement of rules and minimal support from legal institutions, making them useful model systems for investigating the role of social influence in determining economic and environmental outcomes. In such regimes, interpersonal relationships are expected to have a strong effect on a fisher's catch portfolio, the set of fish species targeted by an individual fisher. Here, we test three competing hypotheses about social influence using belief propagation network models and show that a peer-to-peer information-sharing social network is key to explaining catch portfolios at a small-scale fishery in Jamaica. We find that experience dictates the direction of influence among fishers in the social network, with older fishers and information brokers having distinct roles in shaping catch patterns for large- and small-sized fish species, respectively. These findings highlight concrete opportunities for harnessing social networks in natural resource management. Our new approach to modelling social influence is applicable to many social-ecological systems with minimal legal and institutional support or those that rely heavily on bottom-up participatory processes.
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| 16. |
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| 19. |
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| 20. |
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| 21. |
- Bodin, P., et al.
(författare)
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Accounting for interannual variability in agricultural intensification : The potential of crop selection in Sub-Saharan Africa
- 2016
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Ingår i: Agricultural Systems. - : Elsevier BV. - 0308-521X. ; 148, s. 159-168
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Tidskriftsartikel (refereegranskat)abstract
- Providing sufficient food for a growing global population is one of the fundamental global challenges today. Crop production needs not only to be increased, but also remain stable over the years, in order to limit the vulnerability of producers and consumers to inter-annual weather variability, especially in areas of the world where the food consumed is mainly produced locally (e.g. Sub Saharan Africa (SSA)). For subsistence agriculture, stable yields form a crucial contribution to food security. At a regional to global scale dynamical crop models can be used to study the impact of future changes in climate on food production. However, simulations of future crop production, for instance in response to climate change, often do not take into account either changes in the sown areas of crops or yield interannual variability. Here, we explore the response of simulated crop production to assumptions of crop selection, also taking into account interannual variability in yields and considering the response of agricultural productivity to climate change. We apply the dynamic global vegetation model LPJ-GUESS, which is designed to simulate yield over large regions under a changing environment. Model output provides the basis for selecting the relative fractions of sown areas of a range of crops, either by selecting the highest yielding crop, or by using an optimization approach in which crop production is maximized while the standard deviation in crop production is kept at below current levels. Maximizing simulated crop production for current climate while keeping interannual variability in crop production constant at today's level generates rather similar simulated geographical distributions of crops compared to observations. Even so, the optimization results suggest that it is possible to increase crop production regionally by adjusting crop selection, both for current and future climate, assuming the same cropland cover as today. For future climates modelled production increase is > 25% in more than 15% of the grid cells. For a small number of grid cells it is possible to both increase crop production while at the same time decreasing its interannual variability. Selecting the highest yielding crop for any location will lead to a large potential increase in mean food production, but at the cost of a very large increase in variability.
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| 22. |
- Bodin, Per, et al.
(författare)
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Comparing the performance of different stomatal conductance models using modelled and measured plant carbon isotope ratios (δ(13) C): implications for assessing physiological forcing
- 2013
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Ingår i: Global Change Biology. - : Wiley. - 1354-1013. ; 19:6, s. 1709-1719
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Tidskriftsartikel (refereegranskat)abstract
- Accurate modelling of long-term changes in plant stomatal functioning is vital to global climate change studies because changes in evapotranspiration influence temperature via physiological forcing of the climate. Various stomatal models are included in land surface schemes, but their robustness over longer timescales is difficult to validate. We compare the performance of three stomatal models, varying in their degree of complexity, and coupled to a land surface model. This is done by simulating the carbon isotope ratio of tree leaves (δ(13) Cleaf ) over a period of 53 years, and comparing the results with carbon isotope ratios obtained from tree rings (δ(13) Cstem ) measured at six sites in northern Europe. All three stomatal models fail to capture the observed inter-annual variability in the measured δ(13) Cstem time series. However, the Soil-Plant-Atmosphere (SPA) model performs significantly better than the Ball-Berry (BB) or COX models when tested for goodness of fit against measured δ(13) Cstem . The δ(13) Cleaf time series simulated using the SPA model are significantly positively correlated (p < 0.05) with measured results over the full time period tested, at all six sites. The SPA model underestimates inter-annual variability measured in δ(13) Cstem , but is no worse than the BB model and significantly better than the COX model. The inability of current models to adequately replicate changes in stomatal response to rising levels of CO2 concentrations, and thus to quantify the associated physiological forcing, warrants further investigation. © 2013 Blackwell Publishing Ltd.
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| 23. |
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| 24. |
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| 25. |
- Enqvist, Johan P., et al.
(författare)
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Are bottom-up approaches good for promoting social-ecological fit in urban landscapes?
- 2020
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 49:1, s. 49-61
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Tidskriftsartikel (refereegranskat)abstract
- Bottom-up approaches are often presented as a remedy to environmental governance problems caused by poorly aligned social institutions and fragmented ecosystems. However, there is a lack of empirical evidence demonstrating how such social-ecological fit might emerge and help achieve desirable outcomes. This paper combines quantitative social-ecological network analysis with interviews to investigate whether bottom-up approaches in lake governance improve the fit. We study groups of residents seeking to improve management of a network of lakes in Bengaluru, India. Results show that 23 'lake groups' collaborate in a way that aligns with how lakes are hydrologically connected, thus strengthening the social-ecological fit. Three groups founded around 2010 have mobilized support from municipal officers and introduced an ecosystem-based approach to lake management that recognizes their ecological functions and dependence on, the broader hydrological network. These groups have also changed how other lake groups operate: groups founded after 2010 are more collaborative and more prone to contribute to social-ecological fit compared to the older lake groups. This paper demonstrates the utility of a theoretically informed method for examining the impact of bottom-up approaches, which, we argue, is important for a more informed perspective on their relevance and potential contribution to urban environmental governance.
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| 26. |
- Fronzek, Stefan, et al.
(författare)
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Classifying multi-model wheat yield impact response surfaces showing sensitivity to temperature and precipitation change
- 2018
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Ingår i: Agricultural Systems. - : Elsevier BV. - 0308-521X. ; 159, s. 209-224
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Tidskriftsartikel (refereegranskat)abstract
- Crop growth simulation models can differ greatly in their treatment of key processes and hence in their response to environmental conditions. Here, we used an ensemble of 26 process-based wheat models applied at sites across a European transect to compare their sensitivity to changes in temperature (-2 to +9°C) and precipitation (-50 to +50%). Model results were analysed by plotting them as impact response surfaces (IRSs), classifying the IRS patterns of individual model simulations, describing these classes and analysing factors that may explain the major differences in model responses.The model ensemble was used to simulate yields of winter and spring wheat at four sites in Finland, Germany and Spain. Results were plotted as IRSs that show changes in yields relative to the baseline with respect to temperature and precipitation. IRSs of 30-year means and selected extreme years were classified using two approaches describing their pattern.The expert diagnostic approach (EDA) combines two aspects of IRS patterns: location of the maximum yield (nine classes) and strength of the yield response with respect to climate (four classes), resulting in a total of 36 combined classes defined using criteria pre-specified by experts. The statistical diagnostic approach (SDA) groups IRSs by comparing their pattern and magnitude, without attempting to interpret these features. It applies a hierarchical clustering method, grouping response patterns using a distance metric that combines the spatial correlation and Euclidian distance between IRS pairs. The two approaches were used to investigate whether different patterns of yield response could be related to different properties of the crop models, specifically their genealogy, calibration and process description.Although no single model property across a large model ensemble was found to explain the integrated yield response to temperature and precipitation perturbations, the application of the EDA and SDA approaches revealed their capability to distinguish: (i) stronger yield responses to precipitation for winter wheat than spring wheat; (ii) differing strengths of response to climate changes for years with anomalous weather conditions compared to period-average conditions; (iii) the influence of site conditions on yield patterns; (iv) similarities in IRS patterns among models with related genealogy; (v) similarities in IRS patterns for models with simpler process descriptions of root growth and water uptake compared to those with more complex descriptions; and (vi) a closer correspondence of IRS patterns in models using partitioning schemes to represent yield formation than in those using a harvest index.Such results can inform future crop modelling studies that seek to exploit the diversity of multi-model ensembles, by distinguishing ensemble members that span a wide range of responses as well as those that display implausible behaviour or strong mutual similarities.
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| 27. |
- Gullström, Martin, 1968, et al.
(författare)
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Assessment of changes in the seagrass-dominated submerged vegetation of tropical Chwaka Bay (Zanzibar) using satellite remote sensing
- 2006
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Ingår i: Estuarine Coastal and Shelf Science. - : Elsevier BV. - 0272-7714. ; 67:3, s. 399-408
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Tidskriftsartikel (refereegranskat)abstract
- Spatial and temporal dynamics of submerged aquatic vegetation (SAV) cover were studied in the relatively pristine and seagrass-dominated area of Chwaka Bay, Zanzibar (Tanzania) by using satellite remote sensing. Through complementary field work the potential of the technique for change detection was verified. The general changes in SAV cover were examined using Landsat images from 1986, 1987, 1998, 2001 and 2003. Two of these images, from 1987 (Landsat TM) and 2003 (Landsat ETM+), were specifically analysed to create a map of the change in SAV cover. Overall, the general distribution of SAV stayed fairly stable over the period investigated, but the result also showed regions where significant alterations, both losses and gains, had occurred between the two years. Based on our findings and anecdotal information from local fishermen and seaweed farmers potential causative factors are discussed. It was concluded that a repeated mapping with satellite remote sensing is a suitable tool to monitor changes of seagrass and seaweed distribution in shallow tropical environments. (c) 2005 Elsevier Ltd. All rights reserved.
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| 28. |
- Gullström, Martin, et al.
(författare)
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Assessment of vegetation changes in seagrass communities of tropical Chwaka Bay (Zanzibar) using satellite remote sensing
- 2006
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Ingår i: Estuarine, Coastal and Shelf Science. - : Elsevier BV. - 0272-7714 .- 1096-0015. ; 67:3, s. 399-408
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Tidskriftsartikel (refereegranskat)abstract
- Spatial and temporal dynamics of submerged aquatic vegetation (SAV) cover were studied in the relatively pristine and seagrass-dominated area of Chwaka Bay, Zanzibar (Tanzania) by using satellite remote sensing. Through complementary field work the potential of the technique for change detection was verified. The general changes in SAV cover were examined using Landsat images from 1986, 1987, 1998, 2001 and 2003. Two of these images, from 1987 (Landsat TM) and 2003 (Landsat ETM+), were specifically analysed to create a map of the change in SAV cover. Overall, the general distribution of SAV stayed fairly stable over the period investigated, but the result also showed regions where significant alterations, both losses and gains, had occurred between the two years. Based on our findings and anecdotal information from local fishermen and seaweed farmers potential causative factors are discussed. It was concluded that a repeated mapping with satellite remote sensing is a suitable tool to monitor changes of seagrass and seaweed distribution in shallow tropical environments.
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| 29. |
- Gunn, V., et al.
(författare)
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Labour market strategies addressing precarious employment and its impacts : A systematic review
- 2022
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Ingår i: European Journal of Public Health. - : Oxford University Press. - 1101-1262 .- 1464-360X. ; 32:Supplement_3, s. iii43-iii44
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundPrecarious employment (PE), characterized by reduced worker rights, and employment and income insecurity, has complex public health implications including negative impacts on workers’ mental and physical health, occupational health and safety, wellbeing, and inequities in access to health and social protections. There is, however, a knowledge gap regarding effectiveness of interventions. We describe findings from a review of evaluated interventions with potential to address PE.MethodsOur systematic review followed the 2020 PRISMA framework and covered PubMed, Scopus, Web of Science, and sources of grey literature. We included qualitative, quantitative, or mixed-methods studies evaluating initiatives to reduce workers’ PE published from 2000 to 2021 and focused on adult workers.ResultsThe 23 eligible studies from across the world evaluated diverse strategies addressing PE including tax and trade reforms, industrial disputes legislation, business registration, and use of incentives to stimulate permanent contracts. Also included were union strategies to reach precarious workers, the provision of social benefits, and youth apprenticeships. Generally, while most initiatives had the potential to tackle certain PE aspects, they usually acted only on one or two PE dimensions. Additionally, the evaluation components were missing key details, thus, limiting the generalizability of findings, as did the heterogeneity of study designs, initiative purposes, economic and political context, and diverse populations targeted.ConclusionsThe increase in PE prevalence and its complex health implications requires sustainable upstream public health solutions. Multidisciplinary collaborations among public health and occupational health practitioners along with researchers, evaluation specialists, economists, and politicians could facilitate the implementation and evaluation of policies and standards regulating and monitoring PE and its health impacts.Key messages• Precarious employment has complex public health implications.• Sustainable solutions to address precarious employment must be upstream and multidisciplinary.
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| 31. |
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| 33. |
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| 34. |
- Hosie, S., et al.
(författare)
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Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3
- 2019
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Ingår i: Autism Research. - : Wiley. - 1939-3792 .- 1939-3806. ; 12:7, s. 1043-1056
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Tidskriftsartikel (refereegranskat)abstract
- Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Multiple mutations in the neuroligin family of synaptic adhesion molecules are implicated in autism, however whether they are expressed and impact GI function via changes in the enteric nervous system is unknown. We report the GI symptoms of two brothers with autism and an R451C mutation in Nlgn3 encoding the synaptic adhesion protein, neuroligin-3. We confirm the presence of an array of synaptic genes in the murine GI tract and investigate the impact of impaired synaptic protein expression in mice carrying the human neuroligin-3 R451C missense mutation (NL3(R451C)). Assessing in vivo gut dysfunction, we report faster small intestinal transit in NL3(R451C) compared to wild-type mice. Using an ex vivo colonic motility assay, we show increased sensitivity to GABA(A) receptor modulation in NL3(R451C) mice, a well-established Central Nervous System (CNS) feature associated with this mutation. We further show increased numbers of small intestine myenteric neurons in NL3(R451C) mice. Although we observed altered sensitivity to GABA(A) receptor modulators in the colon, there was no change in colonic neuronal numbers including the number of GABA-immunoreactive myenteric neurons. We further identified altered fecal microbial communities in NL3(R451C) mice. These results suggest that the R451C mutation affects small intestinal and colonic function and alter neuronal numbers in the small intestine as well as impact fecal microbes. Our findings identify a novel GI phenotype associated with the R451C mutation and highlight NL3(R451C) mice as a useful preclinical model of GI dysfunction in autism. Autism Res 2019, 12: 1043-1056. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary People with autism commonly experience gastrointestinal problems, however the cause is unknown. We report gut symptoms in patients with the autism-associated R451C mutation encoding the neuroligin-3 protein. We show that many of the genes implicated in autism are expressed in mouse gut. The neuroligin-3 R451C mutation alters the enteric nervous system, causes gastrointestinal dysfunction, and disrupts gut microbe populations in mice. Gut dysfunction in autism could be due to mutations that affect neuronal communication.
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| 35. |
- Jensen, I-B, et al.
(författare)
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The AHA-study: Implementing evidence based measueres for retaining workability at work sites : Effects on lifestyle, workability and firm productivity. 9th International Congress of Behavioral Medicine. Bangkok, Thailand, Nov 29-Dec 2, 2006
- 2006
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Jensen IB, Bergstrom G, Bjorklund C, Fried I, Lisspers J, Nathell L, Hermansson U, Roos P, Bodin L, the AHAstudy group (2006). The AHA-study: Implementing evidence based measueres for retaining workability at work sites - Effcets on lifestyle, workability and firm productivity. Presented at the 9th International Congress of Behavioral Medicine. Bangkok, Thailand, Nov 29-Dec 2, 2006.
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| 36. |
- Johansson, C, et al.
(författare)
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Validity and responsiveness of the spinal cord index of function: an instrument on activity level.
- 2009
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Ingår i: Spinal cord : the official journal of the International Medical Society of Paraplegia. - : Springer Science and Business Media LLC.
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Tidskriftsartikel (refereegranskat)abstract
- Objectives:To evaluate the validity and responsiveness of the Spinal Cord Index of Function (SIF), a new instrument on activity level, measuring the ability to perform various transfers in non-walking patients with a spinal cord lesion.Settings:Spinal Injuries Unit, Sahlgrenska University Hospital, Gothenburg, Sweden.Methods:Twenty-nine patients with a spinal cord lesion classified as grade A, B or C according to the American Spinal Injury Association/International Medical Society of paraplegia classification were included. Each patient was evaluated from the acute phase until discharge, every second week, by their physiotherapist, according to SIF and the Swedish physiotherapy clinical outcome variables (S-COVS). To determine validity, Spearman's rho correlation coefficient was calculated between the total scores of SIF and S-COVS, and the determination coefficient was calculated. Responsiveness was determined by computing effect sizes.Results:Spearman's correlation between SIF and S-COVS was 0.933 and the determination coefficient was 0.87. The effect size for SIF was 9.1.Conclusion:The results of the study prove that SIF is a valid and sensitive instrument, which will be useful for physiotherapists in goal-planning programs and in evaluating progress during a patient's rehabilitation. SIF could also be used in research and in evaluating the patient's functional ability at follow-ups.Spinal Cord advance online publication, 16 June 2009; doi:10.1038/sc.2009.57.
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| 40. |
- Knutsen, Helle Katrine, et al.
(författare)
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Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food.
- 2018
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Ingår i: EFSA journal. European Food Safety Authority. - : Wiley. - 1831-4732. ; 16:12
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Tidskriftsartikel (refereegranskat)abstract
- The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficient sensitivity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were 'Fish and other seafood', 'Meat and meat products' and 'Eggs and egg products', for PFOS, and 'Milk and dairy products', 'Drinking water' and 'Fish and other seafood' for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half-lives for PFOS and PFOA are about 5 years and 2-4 years, respectively. The derivation of a health-based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs.
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| 43. |
- Lundström, Niklas L. P., 1980-, et al.
(författare)
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Meeting yield and conservation objectives by harvesting both juveniles and adults
- 2019
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Ingår i: American Naturalist. - : University of Chicago Press. - 0003-0147 .- 1537-5323. ; 193:3, s. 373-390
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Tidskriftsartikel (refereegranskat)abstract
- Sustainable yields that are at least 80% of the maximum sustainable yield are sometimes referred to as "pretty good yields" (PGY). The range of PGY harvesting strategies is generally broad and thus leaves room to account for additional objectives besides high yield. Here, we analyze stage-dependent harvesting strategies that realize PGY with conservation as a second objective. We show that (1) PGY harvesting strategies can give large conservation benefits and (2) equal harvesting rates of juveniles and adults is often a good strategy. These conclusions are based on trade-off curves between yield and four measures of conservation that form in two established population models, one age-structured model and one stage-structured model, when considering different harvesting rates of juveniles and adults. These conclusions hold for a broad range of parameter settings, although our investigation of robustness also reveals that (3) predictions of the age-structured model are more sensitive to variations in parameter values than those of the stage-structured model. Finally, we find that (4) measures of stability that are often quite difficult to assess in the field (e.g., basic reproduction ratio and resilience) are systematically negatively correlated with impacts on biomass and size structure, so that these later quantities can provide integrative signals to detect possible collapses.
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| 44. |
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| 45. |
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| 46. |
- Matilla-Santander, N., et al.
(författare)
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COVID-19 and Precarious Employment : Consequences of the Evolving Crisis
- 2021
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Ingår i: International Journal of Health Services. - : Sage Publications. - 0020-7314 .- 1541-4469. ; 5:2, s. 226-228
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Tidskriftsartikel (refereegranskat)abstract
- The world of work is facing an ongoing pandemic and an economic downturn with severe effects worldwide. Workers trapped in precarious employment (PE), both formal and informal, are among those most affected by the COVID-19 pandemic. Here we call attention to at least 5 critical ways that the consequences of the crisis among workers in PE will be felt globally: (a) PE will increase, (b) workers in PE will become more precarious, (c) workers in PE will face unemployment without being officially laid off, (d) workers in PE will be exposed to serious stressors and dramatic life changes that may lead to a rise in diseases of despair, and (e) PE might be a factor in deterring the control of or in generating new COVID-19 outbreaks. We conclude that what we really need is a new social contract, where the work of all workers is recognized and protected with adequate job contracts, employment security, and social protection in a new economy, both during and after the COVID-19 crisis.
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| 47. |
- Maury, O., et al.
(författare)
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A global science-policy partnership for progress toward sustainability of oceanic ecosystems and fisheries
- 2013
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Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 5:3-4, s. 314-319
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Forskningsöversikt (refereegranskat)abstract
- Oceanic ecosystems support livelihoods and supply food for hundreds of millions of people. But these ecosystems are deteriorating rapidly and many of the world's oceanic fisheries are in a precarious condition. In addition to well-known and pressing fishery management issues, economic globalization is connecting fisheries beyond the frontiers of the organizations responsible for their management and climate-associated changes are deeply modifying ecosystems, pushing them toward new states and no return situations. The status quo is not a sustainable option, and improved international governance is urgently needed to address this situation. Our proposition consists of an inclusive global science-policy process combining major improvements to the present governance systems, including new incentives for international cooperation and coordination, with an ambitious scientific program to help anticipate threats and opportunities and integrate complex information regarding long-term issues. It would constitute a major step toward sustainability.
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| 48. |
- Meng, Xinzhu, et al.
(författare)
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Dynamics and management of stage-structured fish stocks
- 2013
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Ingår i: Bulletin of Mathematical Biology. - : Springer. - 0092-8240 .- 1522-9602. ; 75:1, s. 1-23
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Tidskriftsartikel (refereegranskat)abstract
- With increasing fishing pressures having brought several stocks to the brink of collapse, there is a need for developing efficient harvesting methods that account for factors beyond merely yield or profit. We consider the dynamics and management of a stage-structured fish stock. Our work is based on a consumer-resource model which De Roos et al. (in Theor. Popul. Biol. 73, 47-62, 2008) have derived as an approximation of a physiologically-structured counterpart. First, we rigorously prove the existence of steady states in both models, that the models share the same steady states, and that there exists at most one positive steady state. Furthermore, we carry out numerical investigations which suggest that a steady state is globally stable if it is locally stable. Second, we consider multiobjective harvesting strategies which account for yield, profit, and the recovery potential of the fish stock. The recovery potential is a measure of how quickly a fish stock can recover from a major disturbance and serves as an indication of the extinction risk associated with a harvesting strategy. Our analysis reveals that a small reduction in yield or profit allows for a disproportional increase in recovery potential. We also show that there exists a harvesting strategy with yield close to the maximum sustainable yield (MSY) and profit close to that associated with the maximum economic yield (MEY). In offering a good compromise between MSY and MEY, we believe that this harvesting strategy is preferable in most instances. Third, we consider the impact of harvesting on population size structure and analytically determine the most and least harmful harvesting strategies. We conclude that the most harmful harvesting strategy consists of harvesting both adults and juveniles, while harvesting only adults is the least harmful strategy. Finally, we find that a high percentage of juvenile biomass indicates elevated extinction risk and might therefore serve as an early-warning signal of impending stock collapse.
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| 49. |
- Pasker-de Jong, P. C., et al.
(författare)
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Psychopharmaceuticals and perinatal deaths
- 1992
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - 0001-6349 .- 1600-0412. ; 71:6, s. 492-3
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Tidskriftsartikel (refereegranskat)
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| 50. |
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