| 1. |
- Bollard, J., et al.
(författare)
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Early formation of planetary building blocks inferred from Pb isotopic ages of chondrules.
- 2017
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- The most abundant components of primitive meteorites (chondrites) are millimeter-sized glassy spherical chondrules formed by transient melting events in the solar protoplanetary disk. Using Pb-Pb dates of 22 individual chondrules, we show that primary production of chondrules in the early solar system was restricted to the first million years after the formation of the Sun and that these existing chondrules were recycled for the remaining lifetime of the protoplanetary disk. This finding is consistent with a primary chondrule formation episode during the early high-mass accretion phase of the protoplanetary disk that transitions into a longer period of chondrule reworking. An abundance of chondrules at early times provides the precursor material required to drive the efficient and rapid formation of planetary objects via chondrule accretion.
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| 2. |
- Albert, Damien, et al.
(författare)
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A Decade with VAMDC : Results and Ambitions
- 2020
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Ingår i: Atoms. - : MDPI. - 2218-2004. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an overview of the current status of the Virtual Atomic and Molecular Data Centre (VAMDC) e-infrastructure, including the current status of the VAMDC-connected (or to be connected) databases, updates on the latest technological development within the infrastructure and a presentation of some application tools that make use of the VAMDC e-infrastructure. We analyse the past 10 years of VAMDC development and operation, and assess their impact both on the field of atomic and molecular (A&M) physics itself and on heterogeneous data management in international cooperation. The highly sophisticated VAMDC infrastructure and the related databases developed over this long term make them a perfect resource of sustainable data for future applications in many fields of research. However, we also discuss the current limitations that prevent VAMDC from becoming the main publishing platform and the main source of A&M data for user communities, and present possible solutions under investigation by the consortium. Several user application examples are presented, illustrating the benefits of VAMDC in current research applications, which often need the A&M data from more than one database. Finally, we present our vision for the future of VAMDC.
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| 3. |
- Antti, Henrik, et al.
(författare)
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Batch statistical processing of 1H NMR-derived urinary spectral data
- 2002
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Ingår i: Journal of Chemometrics: Special Issue: Proceedings of the 7th Scandinavian Symposium on Chemometrics. Issue Edited by Lars Nørgaard. - : Wiley. ; 16:8-10, s. 461-8
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Tidskriftsartikel (refereegranskat)abstract
- Multivariate statistical batch processing (BP) analysis of 1H nuclear magnetic resonance (NMR) urine spectra was employed to establish time-dependent metabolic variations in animals treated with the model hepatotoxin hydrazine. Hydrazine was administered orally to rats (at 90 mg kg-1), and urine samples were collected from dosed rats and matched control animals (n = 5 per group) at time points up to 168 h post-dose. Urine samples were analysed via 1H NMR spectroscopy and partial least squares-based batch processing analysis, treating each rat as an individual batch comprising a series of timed urine samples. A model defining the mean urine profile was established for the control group, and samples obtained from hydrazine-treated animals were assessed using this model. Time-dependent deviations from the control model were evident in all hydrazine-treated animals, and hepatotoxicity was manifested by increased urinary excretion of taurine, creatine, 2-aminoadipate, citrulline and -alanine together with depletion of urinary levels of citrate, succinate and hippurate. The experiment was repeated at six different pharmaceutical centres in order to assess the robustness of the technology and to establish the natural variability in the data. Results were consistent across the data for all centres. BP plots showed a characteristic pattern for each toxin, allowing the time points at which there were maximum metabolic differences to be determined and providing a means of visualizing the net toxin-induced metabolic movement of urinary metabolism. BP may prove to be a powerful metabonomic tool in defining time-dependent metabolic consequences of toxicity and is an efficient means of visualizing inter-animal variations in response as well as defining multivariate statistical limits of normality in terms of biofluid composition.
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