| 1. |
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| 2. |
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| 3. |
- Hernestål-Boman, Jenny, et al.
(författare)
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Signs of dysregulated fibrinolysis precede the development of type 2 diabetes mellitus in a population-based study
- 2012
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Ingår i: Cardiovascular Diabetology. - : BioMed Central. - 1475-2840. ; 11, s. 152-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Diabetic patients experience stimulated coagulation and dysfibrinolysis, which is associated with an increased risk of cardiovascular events. This imbalance may precede the manifest diagnosis. We investigated whether elevated antigen levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), the tPA/PAI-1 complex, or von Willebrand Factor (VWF) precede type 2 diabetes mellitus (T2DM) diagnosis, and whether this elevation occurs before increased fasting plasma glucose (FPG) or 2-hour plasma glucose (2hPG) in individuals who later develop T2DM.Methods: We conducted a prospective incident case-referent study within the Vasterbotten Intervention Programme. Cardiovascular risk factor data as well as FPG and 2hPG and blood samples for future research were collected at a baseline health examination between 1989 and 2000, (n= 28 736). During follow-up in January 2001, 157 cases had developed T2DM. Referents without T2DM were matched for sex, age, and year of participation (n=277). Subgroup analysis was performed for cases with normal baseline glucose levels (FPG <6.1 mmol/L and 2hPG < 8.9 mmol/L) and cases with elevated levels (FPG 6.1-6.9 mmol/L and/or 2hPG 8.9-12.1 mmol/L).Results: After adjusting for BMI, family history of diabetes, physical activity, smoking, systolic blood pressure and levels of C-reactive protein and triglycerides, independent associations were found between incident T2DM and elevated levels of tPA (OR=1.54, 95% CI 1.06-2.23), PAI-1 (OR=1.61, 95% CI 1.14-2.28), and tPA/PAI-1 complex (OR=2.45, 95% CI 1.56-3.84). In participants with normal glucose levels, PAI-1 (OR=2.06, 95% CI 1.10 - 3.86) exhibited an independent relationship with incident T2DM after the adjustments.Conclusions: Elevated levels of fibrinolytic variables precede the manifestation of T2DM after adjusting for metabolic and cardiovascular risk factors and can be detected several years before changes in glucose tolerance.
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| 4. |
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| 5. |
- Agbor, Dieudonné, et al.
(författare)
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On the Modulus of Continuity of Mappings Between Euclidean Spaces
- 2013
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Ingår i: Mathematica Scandinavica. - : Det Kgl. Bibliotek/Royal Danish Library. - 0025-5521 .- 1903-1807. ; 112:1, s. 147-160
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Tidskriftsartikel (refereegranskat)abstract
- Let f be a function from R-P to R-q and let Lambda be a finite set of pairs (theta, eta) is an element of R-P x R-q. Assume that the real-valued function (eta, f(x)) is Lipschitz continuous in the direction theta for every (theta, eta) is an element of Lambda. Necessary and sufficient conditions on Lambda are given for this assumption to imply each of the following: (1) that f is Lipschitz continuous, and (2) that f is continuous with modulus of continuity <= C epsilon vertical bar log epsilon vertical bar.
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| 6. |
- Agranovsky, Mark, et al.
(författare)
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Research biography of a distinguished expert in the field of inverse problems : Professor Eric Todd Quinto
- 2022
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Ingår i: Journal of Inverse and Ill-Posed Problems. - : Walter de Gruyter GmbH. - 0928-0219 .- 1569-3945. ; 30:4, s. 613-617
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Tidskriftsartikel (refereegranskat)abstract
- This article gives a brief overview of the research in microlocal analysis, tomography, and integral geometry of Professor Eric Todd Quinto, Robinson Professor of Mathematics at Tufts University, along with the collaborators and colleagues who influenced his work.
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| 7. |
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| 8. |
- Andersson, Jonas, 1977-, et al.
(författare)
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Effect of intensive lifestyle intervention on C-reactive protein in subjects with impaired glucose tolerance and obesity : results from a randomized controlled trial with 5-year follow-up
- 2008
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Ingår i: Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals. - : Informa UK Limited. - 1366-5804. ; 13:7, s. 671-679
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Tidskriftsartikel (refereegranskat)abstract
- C-reactive protein (CRP) is a marker of metabolic and cardiovascular disease. To study the effects of lifestyle on CRP in a high-risk population we conducted a randomized controlled trial on 200 obese subjects (BMI > 27 kg m(-2)) with impaired glucose tolerance recruited from primary care settings. They were randomized to either a 1-month stay at a wellness centre focusing on diet, exercise and stress management (intervention group) or 30-60 min of oral and written information on lifestyle intervention (control group). A significant reduction of CRP was observed after 1 month and 1 year in the intervention group. They reduced their CRP levels more than the control group 1 year after intervention (p=0.004). In conclusion lifestyle intervention can decrease CRP in obese individuals with impaired glucose tolerance for up to 1 year. Further research is needed to evaluate whether the CRP level reduction translates into a decreased risk for cardiovascular morbidity.
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| 9. |
- Andersson, Jonas, 1977-, et al.
(författare)
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Effects of heavy endurance physical exercise on inflammatory markers in non-athletes
- 2010
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 209:2, s. 601-605
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Physical activity has beneficial effects on cardiovascular disease but the mechanisms are still somewhat unclear. One possible pathway may be through the anti-inflammatory effects attributed to regular physical activity. Our primary aim was to study the effects of endurance physical exercise on C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNFalpha) during the acute and recovery phases. Secondarily, we studied the impact of diet on these inflammatory markers.METHODS: Twenty men, aged 18-55 years, participated in a 14 days cross-country skiing tour. They traveled 12-30km per day corresponding to about 10h of heavy physical activity. The participants were randomized to a diet with either 30 or 40% of energy derived from fat. Inflammatory variables were analysed at week 0, after 1 and 2 weeks and during the recovery phase at week 6 and 8.RESULTS: CRP and TNFalpha increased significantly during the two weeks of exercise (1.4-5.0mg/l, p=0.00 and 6.8-8.4pg/ml, p=0.00). CRP levels were significantly lower during recovery (median 0.7mg/l) compared to baseline (median 1.4mg/l) and did not correlate to metabolic variables. There were no significant changes in IL-6 levels during the study period. For dietary groups significant CRP changes were observed only in the high fat group during recovery.CONCLUSIONS: CRP and TNFalpha increased significantly but reacted differently during heavy physical activity while there seemed to be no significant changes in IL-6. No significant differences regarding inflammatory variables were found between the dietary groups.
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| 10. |
- Andersson, Jonas, 1977-
(författare)
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Inflammation and lifestyle in cardiovascular medicine
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Despite major advances in the treatment and prevention of atherosclerosis the last several decades, cardiovascular disease still accounts for the majority of deaths in Sweden. With the population getting older, more obese and with rising numbers of diabetics, the cardiovascular disease burden may increase further in the future. The focus in cardiovascular disease has shifted with time from calcification and narrowing of arteries to the biological processes within the atherosclerotic plaque. C-reactive protein (CRP) has emerged as one of many proteins that reflect a low grade systemic inflammation and is suitable for analysis as it is more stable and easily measured than most other inflammatory markers. Several large prospective studies have shown that CRP is not only an inflammatory marker, but even a predictive marker for cardiovascular disease. C-reactive protein is associated with several other risk factors for cardiovascular disease including obesity and the metabolic syndrome. Our study of twenty healthy men during a two week endurance cross country skiing tour demonstrated a decline in already low baseline CRP levels immediately after the tour and six weeks later. In a study of 200 obese individuals with impaired glucose tolerance randomised to a counselling session at their health care centre or a one month stay at a wellness centre, we found decreased levels of CRP in subjects admitted to the wellness centre. The effect remained at one, but not after three years of follow-up. In a prospective, nested, case-referent study with 308 ischemic strokes, 61 intracerebral haemorrhages and 735 matched referents, CRP was associated with ischemic stroke in both uni- and multivariate analyses. No association was found with intracerebral haemorrhages. When classifying ischemic stroke according to TOAST criteria, CRP was associated with small vessel disease. The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP, but neither with ischemic stroke nor with intracerebral haemorrhage. A study on 129 patients with atrial fibrillation was used to evaluate whether inflammation sensitive fibrinolytic variables adjusted for CRP could predict recurrence of atrial fibrillation after electrical cardioversion. In multivariate iv models, lower PAI-1 mass was associated with sinus rhythm even after adjusting for CRP and markers of the metabolic syndrome. In conclusion, lifestyle intervention can be used to reduce CRP levels, but it remains a challenge to maintain this effect. CRP is a marker of ischemic stroke, but there are no significant associations between the CRP1444 polymorphism and any stroke subtype, suggesting that the CRP relationship with ischemic stroke is not causal. The fibrinolytic variable, PAI-1, is associated with the risk of recurrence of atrial fibrillation after electrical cardioversion after adjustment for CRP. Our findings suggest a pathophysiological link between atrial fibrillation and PAI-1, but the relation to inflammation remains unclear.
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| 11. |
- Andersson, Joel, et al.
(författare)
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Stability estimates for the local Radon transform
- 2018
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Ingår i: Inverse Problems. - : IOP Publishing. - 0266-5611 .- 1361-6420. ; 34:3
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Tidskriftsartikel (refereegranskat)abstract
- We consider the inverse problem for the 2-dimensional local Radon transform R[f], where f is supported in y >= x(2) and R[f](xi, eta) = integral f (x, xi x + eta) dx is defined near (xi, eta) = (0, 0). We give logarithmic estimates of f in terms of R[f] for functions f that satisfy an a priori bound. For a certain class of smooth, positive weight functions m we give similar estimates for the weighted Radon transform R-m vertical bar f](xi, eta) = integral f (x, xi x + eta) m(xi, eta, x) dx.
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| 12. |
- Andersson, Joel, et al.
(författare)
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Stability estimates with a priori bound for the inverse local Radon transform
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We consider the inverse problem for the 2-dimensional weighted local Radon transform , where is supported in and is defined near . For weight functions satisfying a certain differential equation we give weak estimates of in terms of for functions that satisfies an a priori bound.
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| 13. |
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| 14. |
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| 15. |
- Boman, CarlAxel, et al.
(författare)
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Monitoring of Air Infiltration in Museums, Case study : The National Museum of Fine Arts, Stockholm, Sweden
- 2004
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Ingår i: The 6th Indoor Air Quality Meeting.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper describes tracer gas measurements at the National Museum of Fine Arts in Stockholm. The building was erected 1850-1860 and the architect was Friedrich August Stüler. He created several museums of Fine Arts, among them Neues Museum in Berlin. The museum building in Stockholm has a volume of almost 90 000 m3 and the number of registered objects of art is well over 600 000. The collection includes one of the world’s most prestigious collections of drawings and graphical prints. In this case study the aim was to determine the infiltration through the main entrance and stairwell, through windows and outside walls. The measurement technique used was the Homogeneous Emission Technique added with a 2-zone set up, by using two different tracer gases. Several interesting results were obtained. One result was that more airtight entrance doors would decrease the infiltration into the main stairwell with 40 %. Another result of interest was that the very dry outdoor air was mixed with the indoor air quickly, and that the mechanical ventilation system with filters and humidifying units has to be upgraded to compensate for the outdoor air infiltration.
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| 16. |
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| 17. |
- Boman, Jan, 1933-
(författare)
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A hypersurface containing the support of a Radon transform must be an ellipsoid. I
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- If the Radon transform of a compactly supported distribution f≠ 0 in R^n is supported on the set of tangent planes to the boundary ∂D of a bounded convex domain D, then ∂D must be an ellipsoid. As a corollary of this result we get a new proof of a recent theorem of Koldobsky, Merkurjev, and Yaskin, which settled a special case of a conjecture of Arnold that was motivated by a famous lemma of Newton.
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| 18. |
- Boman, Jan
(författare)
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A Hypersurface Containing the Support of a Radon Transform must be an Ellipsoid. I : The Symmetric Case
- 2021
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Ingår i: Journal of Geometric Analysis. - : Springer Science and Business Media LLC. - 1050-6926 .- 1559-002X. ; 31:4, s. 2726-2741
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Tidskriftsartikel (refereegranskat)abstract
- If the Radon transform of a compactly supported distribution f not equal 0 in Rn is supported on the set of tangent planes to the boundary partial derivative D of a bounded convex domain D, then partial derivative D must be an ellipsoid. As a corollary of this result we get a new proof of a recent theorem of Koldobsky, Merkurjev, and Yaskin, which settled a special case of a conjecture of Arnold that was motivated by a famous lemma of Newton.
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| 19. |
- Boman, Jan
(författare)
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A hypersurface containing the support of a Radon transform must be an ellipsoid. II : The general case
- 2021
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Ingår i: Journal of Inverse and Ill-Posed Problems. - : Walter de Gruyter GmbH. - 0928-0219 .- 1569-3945. ; 29:3, s. 351-367
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Tidskriftsartikel (refereegranskat)abstract
- If the Radon transform of a compactly supported distribution f not equal 0 in R-n is supported on the set of tangent planes to the boundary partial derivative D of a bounded convex domain D, then partial derivative D must be an ellipsoid. The special case of this result when the domain D is symmetric was treated in [J. Boman, A hypersurface containing the support of a Radon transform must be an ellipsoid. I: The symmetric case, J. Geom. Anal. (2020), DOI 10.1007/s12220-020-00372-8]. Here we treat the general case.
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| 20. |
- Boman, Jan, 1933-
(författare)
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A local uniqueness theorem for weighted Radon transforms
- 2010
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Ingår i: Inverse Problems and Imaging. - : American institute of mathematical sciences. - 1930-8337 .- 1930-8345. ; 4:4, s. 631-637
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Tidskriftsartikel (refereegranskat)abstract
- We consider a weighted Radon transform in the plane, , where is a smooth, positive function. Using an extension of an argument of Strichartz we prove a local injectivity theorem for for essentially the same class of that was considered by Gindikin in his article in this issue.
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| 21. |
- Boman, Johan, 1955, et al.
(författare)
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ASSESSING THE ENVIRONMENT WITH X-RAY FLUORESCENCE
- 2011
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Ingår i: Advances in X-ray Analysis. - 0376-0308. ; 54, s. 266-279
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we will introduce the general benefits of X-Ray Fluorescence spectrometry (XRF) for assessing the condition of the outer environment, especially where ambient aerosol particles are causing environmental disturbances. Examples from recent environmental studies are presented, and energy dispersive XRF is concluded to be a powerful, nondestructive yet easily applicable tool to supply detailed elemental information of particles collected in different applications. The further development and future potential of the method for detailed analysis of aerosol particles are discussed.
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| 22. |
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| 23. |
- Boman, Jan
(författare)
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Flatness of distributions vanishing on infinitely many hyperplanes
- 2009
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Ingår i: Comptes rendus. Mathematique. - : Elsevier BV. - 1631-073X .- 1778-3569. ; 347:23-24, s. 1351-1354
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Tidskriftsartikel (refereegranskat)abstract
- Let be a family of hyperplanes in Rn and let L0 be a limiting hyperplane of {Lk}. Let u be a distribution that satisfies a natural wave front condition and has vanishing restrictions to Lk for all k1. Then u must be flat at L0.
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| 24. |
- Boman, Jan, 1933-
(författare)
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Local non-injectivity for weighted Radon transforms
- 2011
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Ingår i: Contemporary Mathematics. - : American Mathematical Society (AMS). - 0271-4132 .- 1098-3627. ; 559, s. 39-47
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Tidskriftsartikel (refereegranskat)abstract
- A weighted plane Radon transform $R_{\rho}$ is considered, where $\rho(x, L)$ is a smooth positive function. It is proved that the set of weight functions $\rho$, for which the map $f \mapsto R_{\rho} f$ is not locally injective, is dense in the space of smooth positive weight functions.
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| 25. |
- Boman, Jan, 1933-
(författare)
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Mathematical reminiscences
- 2010
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Ingår i: Inverse problems and imaging. - : American Institute of Matheamtical Sciences. - 1930-8337. ; 4:4, s. 571-577
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Tidskriftsartikel (refereegranskat)
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| 26. |
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| 27. |
- Boman, J., et al.
(författare)
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Novikov's inversion formula for the attenuated radon transform - A new approach
- 2004
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Ingår i: Journal of Geometric Analysis. - 1050-6926 .- 1559-002X. ; 14:2, s. 185-198
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Tidskriftsartikel (refereegranskat)abstract
- We study the inversion of weighted Radon transforms in two dimensions, R-rho f (L) = f(L) f((.)) rho (L, (.)) ds, where the weight function rho (L, x), L a line and x is an element of L, has a special form. It was an important breakthrough when R. G. Novikov recently gave an explicit formula for the inverse of R-rho When rho has the form (1.2); in this case R-rho is called the attenuated Radon transform. Here. we prove similar results,for a somewhat larger class of rho using completely different and quite elementary methods.
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| 28. |
- Boman, Jan, 1933-
(författare)
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On local injectivity for weighted Radon transforms
- 2012
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Ingår i: The mathematical legacy of Leon Ehrenpreis. - Milano : Springer Milan. - 9788847019461 - 884701946X ; , s. 45-60
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Bokkapitel (refereegranskat)abstract
- We consider a class of weighted plane generalized Radon transforms Rf(γ)=∫f(x,u(ξ,η,x))m(ξ,η,x) dx, where the curve γ=γ(ξ,η) is defined by y=u(ξ,η,x), and m(ξ,η,x) is a given positive weight function. We prove local injectivity for this transform across a given curve γ0 near a given point (x0,y0) on γ0 for classes of curves and weight functions that are invariant under arbitrary smooth coordinate transformations in the plane.
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| 29. |
- Boman, Jan
(författare)
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On stable region-of-interest reconstruction in tomography : examples of non-existence of bounded inverse
- 2016
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Ingår i: Inverse Problems. - : IOP Publishing. - 0266-5611 .- 1361-6420. ; 32:12
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Tidskriftsartikel (refereegranskat)abstract
- In applications of computerized tomography (CT) it is often of interest to reconstruct a function in a proper subset, the region of interest (ROI), of its support from a proper subset of a full CT-scan. In several recent works it has been shown that stable ROI reconstruction is possible in certain limited data situations. In this paper we investigate the limits of what is possible in that direction by proving that reconstruction in an interior ROI is severely unstable for a certain set of data that contains integrals over all lines that intersect the ROI and is large enough for the unknown function to be uniquely determined.
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| 30. |
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| 31. |
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| 32. |
- Boman, Jan, 1933-
(författare)
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Regularity of a Distribution and of the Boundary of Its Support
- 2022
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Ingår i: Journal of Geometric Analysis. - : Springer Science and Business Media LLC. - 1050-6926 .- 1559-002X. ; 32:12
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Tidskriftsartikel (refereegranskat)abstract
- In two recent papers, Boman (J Geom Anal 31:2726–2741, 2020, https://doi.org/10.1007/s12220-020-00372-8, J Ill-posed Inverse Probl 2021, https://doi.org/10.1515/jiip-2020-0139), we proved that the Radon transform of a compactly supported distribution can be supported in the set of supporting planes to a bounded, convex domain D⊂Rn only if the boundary of D is an ellipsoid. Using closely related methods we study here the relationship between the analytic wave front set for the characteristic function, χD, of a domain D⊂Rn and singularities of the boundary ∂D of the domain. For instance we prove that the boundary surface must be real analytic in a neighborhood of a point z∈∂D∈C1, if the analytic wave front set of χD at z contains no other elements than the conormals to ∂D at z.
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| 33. |
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| 34. |
- Boman, Jan, et al.
(författare)
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Schrödinger Operators on Graphs and Geometry II. Spectral Estimates for L-1-potentials and an Ambartsumian Theorem
- 2018
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Ingår i: Integral equations and operator theory. - : Springer Science and Business Media LLC. - 0378-620X .- 1420-8989. ; 90:3
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we study Schrodinger operators with absolutely integrable potentials on metric graphs. Uniform bounds-i.e. depending only on the graph and the potential-on the difference between the eigenvalues of the Laplace and Schrodinger operators are obtained. This in turn allows us to prove an extension of the classical Ambartsumian Theorem which was originally proven for Schrodinger operators with Neumann conditions on an interval. We also extend a previous result relating the spectrum of a Schrodinger operator to the Euler characteristic of the underlying metric graph.
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| 35. |
- Boman, Jan, 1933-
(författare)
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Siciak's theorem on separate analyticity
- 2017
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Ingår i: Analysis Meets Geometry. - Cham : Birkhäuser Verlag. - 9783319524696 - 9783319524719 ; , s. 135-145
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Bokkapitel (refereegranskat)abstract
- We give a simple proof of an important special case of the famous theorem of Jósef Siciak on separate analyticity
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| 36. |
- Boman, Jan, et al.
(författare)
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STABILITY ESTIMATES IN TENSOR TOMOGRAPHY
- 2018
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Ingår i: Inverse Problems and Imaging. - : American Institute of Mathematical Sciences (AIMS). - 1930-8337 .- 1930-8345. ; 12:5, s. 1245-1262
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Tidskriftsartikel (refereegranskat)abstract
- We study the X-ray transform I of symmetric tensor fields on a smooth convex bounded domain Omega C R-n. The main result is the stability estimate parallel to(s)f parallel to(L2) <= C parallel to If parallel to(H1/2), where (s)f is the solenoidal part of the tensor field f. The proof is based on a comparison of the Dirichlet integrals for the exterior and interior Dirichlet problems and on a generalization of the Korn inequality to symmetric tensor fields of arbitrary rank.
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| 37. |
- Boman, Jan, et al.
(författare)
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Support Theorems for the Radon Transform and Cram,r-Wold Theorems
- 2009
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Ingår i: Journal of theoretical probability. - : Springer Science and Business Media LLC. - 0894-9840 .- 1572-9230. ; 22:3, s. 683-710
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Tidskriftsartikel (refereegranskat)abstract
- This article presents extensions of the Cram,r-Wold theorem to measures that may have infinite mass near the origin. Corresponding results for sequences of measures are presented together with examples showing that the assumptions imposed are sharp. The extensions build on a number of results and methods concerned with injectivity properties of the Radon transform. Using a few tools from distribution theory and Fourier analysis we show that the presented injectivity results for the Radon transform lead to Cram,r-Wold type results for measures. One purpose of this article is to contribute to making known to probabilists interesting results for the Radon transform that have been developed essentially during the 1980s and 1990s.
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| 38. |
- Boman, Jan
(författare)
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Support theorems for the Radon transform and Cramér-Wold theorems
- 2007
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This article presents extensions of the Cramér-Wold theorem to measures that may have infinite mass near the origin. Corresponding results for sequences of measures are presented together with examples showing that the assumptions imposed are sharp. The extensions build on a number of results and methods concerned with injectivity properties of the Radon transform. Using a few tools from distribution theory and Fourier analysis we show that the presented injectivity results for the Radon transform lead to Cramér-Wold type results for measures. One purpose of this article is to contribute to making known to probabilists interesting results for the Radon transform that have been developed essentially during the 1980ies and 1990ies.
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| 39. |
- Boman, Jan, 1933-, et al.
(författare)
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To the memory of Lars Hörmander (1931 - 2012)
- 2015
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Ingår i: Notices of the American Mathematical Society. - 0002-9920 .- 1088-9477. ; 62:8, s. 890-907
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Tidskriftsartikel (refereegranskat)
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| 40. |
- Boman, Jan, 1933-
(författare)
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Unique continuation of microlocally analytic distributions and injectivity theorems for the ray transform
- 2010
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Ingår i: Inverse Problems and Imaging. - : American Institute of Mathematical Sciences. - 1930-8337 .- 1930-8345. ; 4:4, s. 619-630
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Tidskriftsartikel (refereegranskat)abstract
- Using a vanishing theorem for microlocally real analytic distributions and a theorem on flatness of a distribution vanishing on infinitely many hyperplanes we give a new proof of an injectivity theorem of Bélisle, Massé, and Ransford for the ray transform on R^n. By means of an example we show that this result is sharp. An extension is given where real analyticity is replaced by quasianalyticity.
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| 41. |
- Boman, Kurt, et al.
(författare)
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Effects of carvedilol or metoprolol on PAI-1, tPA-mass concentration or Von Willebrand factor in chronic heart failure--a COMET substudy.
- 2010
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Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 125:2, s. e46-50
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: In COMET (Carvedilol or Metoprolol European Trial), carvedilol reduced mortality compared with metoprolol in patients with chronic heart failure. We hypothesized that carvedilol might have greater effects on endothelial derived haemostatic factors than metoprolol. We aimed to study the effects of carvedilol or metoprolol on tissue plasminogen activator (tPA), its inhibitor PAI-1 and Von Willebrand factor (VWF) in patients with heart failure. MATERIAL AND METHODS: We recruited 260 patients (134 on carvedilol, 126 on metoprolol), mean age 66 years and 84% of them men. Plasma mass concentrations of tPA and PAI-1and percent of VWF were measured at baseline and after one and two years of treatment. RESULTS: Plasma tPA, PAI-1 and VWF were similar between treatment groups at baseline and no significant differences between groups emerged after one or two years of treatment. In paired analyses in patients assigned to carvedilol, median PAI-1 level decreased from 37.2 to 32.1 microg/l at two years (p=0.034) and of VWF decreased from baseline to one year (240 vs. 218%, p=0.023) in patients assigned to carvedilol but were not reduced at any time in patients assigned to metoprolol. Plasma tPA increased over time in both treatment groups (p=0.013 and 0.027 respectively). CONCLUSION: We found no significant difference in the effects of carvedilol or metoprolol on tPA, PAI-1 and VWF. Comparison over time within treatment groups suggested that PAI-1 and VWF might have declined on carvedilol but not on metoprolol. Our hypothesis is not proved but this may reflect an inadequate sample size rather than lack of an effect.
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| 42. |
- Boman, Kurt, et al.
(författare)
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Healthcare resource utilisation and costs associated with a heart failure diagnosis : A retrospective, population-based cohort study in Sweden
- 2021
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 11:10
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To examine healthcare resource use (HRU) and costs among heart failure (HF) patients using population data from Sweden.Design: Retrospective, non-interventional cohort study.Setting: Two cohorts were identified from linked national health registers (cohort 1, 2005-2014) and electronic medical records (cohort 2, 2010-2012; primary/secondary care patients from Uppsala and Västerbotten).Participants: Patients (aged ≥18 years) with primary or secondary diagnoses of HF (≥2 International Classification of Diseases and Related Health Problems, 10th revision classification) during the identification period of January 2005 to March 2015 were included.Outcome measures: HRU across the HF phenotypes was assessed with logistic regression. Costs were estimated based on diagnosis-related group codes and general price lists.Results: Total annual costs of secondary care of prevalent HF increased from SEK 6.23 (€0.60) to 8.86 (€0.85) billion between 2005 and 2014. Of 4648 incident patients, HF phenotype was known for 1715: reduced ejection fraction (HFrEF): 64.5%, preserved ejection fraction (HFpEF): 35.5%. Within 1 year of HF diagnosis, the proportion of patients hospitalised was only marginally higher for HFrEF versus HFpEF (all-cause (95% CI): 64.7% (60.8 to 68.4) vs 63.7% (60.8 to 66.5), HR 0.91, p=0.14; cardiovascular disease related (95% CI): 61.1% (57.1 to 64.8) vs 60.9% (58.0 to 63.7), HR 0.93, p=0.28). Frequency of hospitalisations and outpatient visits per patient declined after the first year. All-cause secondary care costs in the first year were SEK 122 758 (€12 890)/patient/year, with HF-specific care accounting for 69% of the costs. Overall, 10% of the most expensive population (younger; predominantly male; more likely to have comorbidities) incurred ~40% of total secondary care costs.Conclusions: HF-associated costs and HRU are high, especially during the first year of diagnosis. This is driven by high hospitalisations rates. Understanding the profile of resource-intensive patients being at younger age, male sex and high Charlson comorbidity index scores at the time of the HF diagnosis is most likely a sign of more severe disease.
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| 43. |
- Boman, Kurt, et al.
(författare)
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Man ska lyssna på patienten : ovanlig grund till hjärtsvikt upptäcktes efter 40 år
- 2013
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Ingår i: Läkartidningen. - Stockholm : Sveriges läkarförbund. - 0023-7205 .- 1652-7518. ; 110:29-31, s. 346-347
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Tidskriftsartikel (refereegranskat)abstract
- Vid hjärtsvikt kan vikten av att identifiera bakomliggande orsak aldrig nog betonas. Avancerade undersökningar ger inte alltid diagnos om man inte har en noggrann anamnes och auskultation som grund. Beakta alltid risken av en okritisk förförståelse; ju fler undersökningar som är gjorda, desto större är risken, dvs att man förlitar sig på tidigare satta diagnoser utan att kritiskt granska underlaget. Vid oklara fall behövs tid och utrymme för reflexion och omprövning, vilket måhända kan komma i konflikt med en hårt processdriven och ekonomiskt inriktad sjukvård.
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| 44. |
- Boman, Mats, et al.
(författare)
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Laser micromachining
- 2001
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Ingår i: Invited talk, Micro- and Nanotechnologies LSU/CAMD Summer School 2001, Baton Rouge, LA, USA. - 2001.
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Konferensbidrag (refereegranskat)
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| 45. |
- Boman, Tomas
(författare)
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Situationen på den svenska arbetsmarknaden för personer med funktionsnedsättning : en sekundäranalys om sysselsättning, yrkesnivå, diskriminering, stöd och anpassning för personer med olika typer av funktionsnedsättning
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis is to explore how the labour market situation appears to persons with different types of disabilities in Sweden. Study I (n=4 359) examined the importance of the person’s type of disability for the possibility of having a job. Study II (n=3 396) examined whether there were differences in occupational attainment between persons with different types of disabilities and between persons with and without a disability (n=19 004). Study III (n=4 359) examined perceived discrimination in the workplace among persons with different types of disabilities. Study IV (n=2 268) examined whatsupport and adaptation persons with different types of disabilities need in their actual workplace or to enter the labour market. In studies I–III the respondents were divided into six disability types, and in study IV the respondents were divided into four disability types.Overall, it can be concluded that a person’s type of disability is of importance for the situation in the labour market, where persons with psychological disabilities encounter barriers to a greater extent than other groups, both difficulties at the present workplace and difficulties entering the labour market. Further, they were subjected to discrimination and they expressed a great need for adaptations to acquire employment and at their actual workplace. It can also be concluded that there are discriminatory mechanisms against women, who have more difficulties than men in acquiring employment, and that men, despite lower education, can more easily progress in the labour market. It is suggested that, in order to achieve inclusion and recognition, factors in the environment, such as existing support systems, need to be changed and developed, and social prejudices vis-à-vis people with disabilities must also be addressed.
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| 46. |
- Bølling, Anette Kocbach, et al.
(författare)
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Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines.
- 2012
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Ingår i: Particle and fibre toxicology. - : Springer Science and Business Media LLC. - 1743-8977. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT: BACKGROUND: Exposure to particulate matter (PM) has been linked to several adverse cardiopulmonary effects, probably via biological mechanisms involving inflammation. The pro-inflammatory potential of PM depends on the particles' physical and chemical characteristics, which again depend on the emitting source. Wood combustion is a major source of ambient air pollution in northern countries during the winter season. The overall aim of this study was therefore to investigate the cellular responses to wood smoke particles (WSPs) collected from different phases of the combustion cycle, and from combustion at different temperatures. RESULTS: WSPs from different phases of the combustion cycle induced very similar effects on pro-inflammatory mediator release, cytotoxicity and cell number, whereas WSPs from medium-temperature combustion were more cytotoxic than WSPs from high-temperature incomplete combustion. Furthermore, comparisons of effects induced by native WSPs with the corresponding organic extracts and washed particles revealed that the organic fraction was the most important determinant for the WSP-induced effects. However, the responses induced by the organic fraction could generally not be linked to the content of the measured polycyclic aromatic hydrocarbons (PAHs), suggesting that also other organic compounds were involved. CONCLUSION: The toxicity of WSPs seems to a large extent to be determined by stove type and combustion conditions, rather than the phase of the combustion cycle. Notably, this toxicity seems to strongly depend on the organic fraction, and it is probably associated with organic components other than the commonly measured unsubstituted PAHs.
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| 47. |
- Carlehed, Magnus, et al.
(författare)
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Mikael passare
- 2017
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Ingår i: Analysis Meets Geometry. Trends in Mathematics. Andersson M., Boman J., Kiselman C., Kurasov P., Sigurdsson R. (eds). - Cham : Springer. - 2297-0215 .- 2297-024X. - 9783319524719 - 9783319524696 ; , s. 59-60
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- I got to know Mikael in the eighties, when I was a PhD student at Stockholm University. I had completed a number of graduate courses and became interested in complex analysis. Mikael was a young lecturer in Stockholm, and our overlapping interest in that subject brought us into each other’s orbits.
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| 48. |
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| 49. |
- Elihn, K, et al.
(författare)
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Nanoparticle formation by laser-assisted photolysis of ferrocene.
- 1999
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Ingår i: NANOSTRUCTURED MATERIALS. - 0965-9773. ; 12:1-4, s. 79-82
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Tidskriftsartikel (refereegranskat)abstract
- Laser-assisted formation of iron-containing nanoparticles has been performed by photolytic dissociation of ferrocene vapour by a pulsed ArF excimer laser at 193 nm. The process was carried out at atmospheric pressure, either in an inert atmosphere of argo
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| 50. |
- Elihn, Kristina, et al.
(författare)
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Size distributions and synthesis of nanoparticles by photolytic dissociation of ferrocene
- 2001
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Ingår i: APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING. - 0947-8396. ; 72:1, s. 29-34
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Tidskriftsartikel (refereegranskat)abstract
- Iran-containing nanoparticles were made by laser-assisted (ArF excimer laser, lambda = 193 nm) photolytic dissociation of ferrocene (Fe(C5H5)(2) or FeCp2) in argon and an oxygen/argon gas mixture. The particle-size distributions were obtained on-line by u
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