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1.	Amogne, W, et al. (author) Phylogenetic Analysis of Ethiopian HIV-1 Subtype C Near Full-Length Genomes Reveals High Intrasubtype Diversity and a Strong Geographical Cluster 2016 In: AIDS research and human retroviruses. - : Mary Ann Liebert Inc. - 1931-8405 .- 0889-2229. ; 32:5, s. 471-474 Journal article (peer-reviewed)
2.	Andersson, E, et al. (author) Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveys 2013 In: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. - : Elsevier BV. - 1567-7257. ; 18, s. 125-131 Journal article (peer-reviewed)
3.	Azim, T, et al. (author) Women, drugs and HIV 2015 In: The International journal on drug policy. - : Elsevier BV. - 1873-4758 .- 0955-3959. ; 2626 Suppl 1, s. S16-S21 Journal article (peer-reviewed)
4.	Bontell, I, et al. (author) Molecular dating of HIV-1 subtype C from Bangladesh 2013 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:11, s. e79193- Journal article (peer-reviewed)
5.	Bontell, I, et al. (author) Transmitted drug resistance and phylogenetic analysis of HIV CRF01_AE in Northern Vietnam 2012 In: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. - : Elsevier BV. - 1567-7257. ; 12:2, s. 448-452 Journal article (peer-reviewed)
6.	Bontell, I, et al. (author) Trends in antiretroviral therapy and prevalence of HIV drug resistance mutations in Sweden 1997-2011 2013 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:3, s. e59337- Journal article (peer-reviewed)
7.	Neogi, U, et al. (author) Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals 2013 In: Journal of the International AIDS Society. - 1758-2652. ; 16, s. 18472- Journal article (peer-reviewed)
8.	Neogi, U, et al. (author) Molecular epidemiology of HIV-1 subtypes in India: origin and evolutionary history of the predominant subtype C 2012 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:6, s. e39819- Journal article (peer-reviewed)
9.	Neogi, U, et al. (author) Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients 2014 In: AIDS (London, England). - 1473-5571. ; 28:15, s. 2319-2322 Journal article (peer-reviewed)
10.	van Hooren, Luuk, et al. (author) Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma. 2021 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1 Journal article (peer-reviewed)abstract Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of αCD40 induces hypofunctional T cells and impairs the response to immune checkpoint inhibitors in pre-clinical glioma models. This is associated with a systemic induction of suppressive CD11b+ B cells post-αCD40 treatment, which accumulate in the tumor microenvironment. Our work unveils the pleiotropic effects of αCD40 therapy in glioma and reveals that immunotherapies can modulate TLS formation in the brain, opening up for future opportunities to regulate the immune response.

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Type of publication: journal article (10)

Type of content: peer-reviewed (10)

Author/Editor: Bontell, I (9); Sonnerborg, A (8); Neogi, U (4); Shet, A (3); Diwan, V (2); Cuong, DD (2); show more...; Wondwossen, A (2); Azim, T (2); Banerjea, AC (2); Albert, J. (1); Gupta, S. (1); Soni, N. (1); Andersson, E (1); Essand, Magnus (1); Larsson, M (1); Aderaye, G (1); Lindquist, L (1); Agneskog, E (1); Rahman, M (1); Bratt, G (1); Amogne, W (1); De Costa, A (1); Jakola, Asgeir Store (1); Libard, Sylwia (1); Schulter, E (1); Kaiser, R (1); Grossmann, S (1); Dimberg, Anna (1); Shao, W (1); Cham, F (1); Morris, L (1); Hunt, G (1); Bertagnolio, S (1); Maldarelli, F (1); Jordan, MR (1); Smits, Anja (1); Ramachandran, Mohanr ... (1); Prasad, VR (1); Ranga, U (1); Lau, Joey, 1979- (1); Karlsson, Mikael C I (1); Zetterling, Maria (1); Strathdee, SA (1); Wanchu, A (1); Mangsbo, Sara M., 19 ... (1); Ulvmar, Maria H. (1); Bontell, Thomas Olss ... (1); Huang, Hua, 1986- (1); Sarker, MS (1); Afrad, MH (1); show less...

University: Karolinska Institutet (10); University of Gothenburg (1); Uppsala University (1)

Language: English (10)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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