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Sökning: WFRF:(Borén Thomas)

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1.
  • Mahdavi, Jafar, et al. (författare)
  • Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
  • 2002
  • Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 297:5581, s. 573-578
  • Tidskriftsartikel (refereegranskat)abstract
    • Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.
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2.
  • Aspholm-Hurtig, Marina, et al. (författare)
  • Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
  • 2004
  • Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5683, s. 519-22
  • Tidskriftsartikel (refereegranskat)abstract
    • Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
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3.
  • Borén, Thomas, 1967- (författare)
  • Meeting-places of Transformation : Urban Identity, Spatial Representations and Local Politics in St Petersburg, Russia
  • 2005
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This study develops a model for understanding spatial change and the construction of space as a meeting-place, and then employs it in order to show an otherwise little-known picture of (sub-)urban Russia and its transformation from Soviet times to today. The model is based on time-geographic ideas of time-space as a limited resource in which forces of various kinds struggle for access and form space in interaction with each other. Drawing on cultural semiotics and the concepts of lifeworld and system, the study highlights the social side of these space-forming forces. Based on a long-term fieldwork (participant observation) in Ligovo/Uritsk, a high-rise residential district developed around 1970 and situated on the outskirts of Sankt-Peterburg (St Petersburg), the empirical material concerns processes of urban identity, spatial representations and local politics. The study explicates three codes used to form the image of the city that all relate to its pre-Revolutionary history, two textual strategies of juxtaposition in creating the genius loci of a place, and a discussion of what I call Soviet "stiff landscape" in relation to Soviet mental and ordinary maps of the urban landscape. Moreover, the study shows that the newly implemented self-governing municipalities have not realised their potential as political actors in forming local space, which raises questions on the democratisation of urban space. Finally, the study argues that the model that guides the research is a tool that facilitates the application of the world-view of time-geography and the epistemology of the landscape of courses in concrete research. The study ends with an attempt to generalise spatial change in four types.
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5.
  • Lundén, Thomas, et al. (författare)
  • A hundred years later. Streetcars are still rattling in Baltic cities
  • 2012
  • Ingår i: Baltic Worlds. - 2000-2955 .- 2001-7308. ; 5:3-4, s. 37-44
  • Tidskriftsartikel (refereegranskat)abstract
    • A young geographer by the name of Sten DeGeer mapped the cities around the Baltic Sea in an article published in 1912. As an attempt to capture the urban structure of Baltic region cities, his paper is unique. In this article, we comment on his meticulous descriptions of these cities, with a century long perspective.
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7.
  • Prakobphol, A, et al. (författare)
  • Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340.
  • 2000
  • Ingår i: The Journal of biological chemistry. - 0021-9258 .- 1083-351X. ; 275:51, s. 39860-6
  • Tidskriftsartikel (refereegranskat)abstract
    • Salivary agglutinin is a high molecular mass component of human saliva that binds Streptococcus mutans, an oral bacterium implicated in dental caries. To study its protein sequence, we isolated the agglutinin from human parotid saliva. After trypsin digestion, a portion was analyzed by matrix-assisted laser/desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), which gave the molecular mass of 14 unique peptides. The remainder of the digest was subjected to high performance liquid chromatography, and the separated peptides were analyzed by MALDI-TOF/post-source decay; the spectra gave the sequences of five peptides. The molecular mass and peptide sequence information showed that salivary agglutinin peptides were identical to sequences in lung (lavage) gp-340, a member of the scavenger receptor cysteine-rich protein family. Immunoblotting with antibodies that specifically recognized either lung gp-340 or the agglutinin confirmed that the salivary agglutinin was gp-340. Immunoblotting with an antibody specific to the sialyl Le(x) carbohydrate epitope detected expression on the salivary but not the lung glycoprotein, possible evidence of different glycoforms. The salivary agglutinin also interacted with Helicobacter pylori, implicated in gastritis and peptic ulcer disease, Streptococcus agalactiae, implicated in neonatal meningitis, and several oral commensal streptococci. These results identify the salivary agglutinin as gp-340 and suggest it binds bacteria that are important determinants of either the oral ecology or systemic diseases.
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8.
  • Roche, Niamh, 1969, et al. (författare)
  • Helicobacter pylori and complex gangliosides.
  • 2004
  • Ingår i: Infection and immunity. - 0019-9567. ; 72:3, s. 1519-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Recognition of sialic acid-containing glycoconjugates by the human gastric pathogen Helicobacter pylori has been repeatedly demonstrated. To investigate the structural requirements for H. pylori binding to complex gangliosides, a large number of gangliosides were isolated and characterized by mass spectrometry and proton nuclear magnetic resonance. Ganglioside binding of sialic acid-recognizing H. pylori strains (strains J99 and CCUG 17874) and knockout mutant strains with the sialic acid binding adhesin SabA or the NeuAcalpha3Galbeta4GlcNAcbeta3Galbeta4GlcNAcbeta-binding neutrophil-activating protein HPNAP deleted was investigated using the thin-layer chromatogram binding assay. The wild-type bacteria bound to N-acetyllactosamine-based gangliosides with terminal alpha3-linked NeuAc, while gangliosides with terminal NeuGcalpha3, NeuAcalpha6, or NeuAcalpha8NeuAcalpha3 were not recognized. The factors affecting binding affinity were identified as (i) the length of the N-acetyllactosamine carbohydrate chain, (ii) the branches of the carbohydrate chain, and (iii) fucose substitution of the N-acetyllactosamine core chain. While the J99/NAP(-) mutant strain displayed a ganglioside binding pattern identical to that of the parent J99 wild-type strain, no ganglioside binding was obtained with the J99/SabA(-) mutant strain, demonstrating that the SabA adhesin is the sole factor responsible for the binding of H. pylori bacterial cells to gangliosides.
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9.
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10.
  • Adiels, Martin, 1976, et al. (författare)
  • Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins.
  • 2010
  • Ingår i: Rapid communications in mass spectrometry : RCM. - : Wiley. - 1097-0231 .- 0951-4198. ; 24:5, s. 586-592
  • Tidskriftsartikel (refereegranskat)abstract
    • Stable isotope kinetic studies play an important role in the study of very-low density lipoprotein (VLDL) metabolism, including basic and clinical research. Today, [1,1,2,3,3-(2)H(5)]glycerol is the most cost-effective alternative to measure glycerol and triglyceride kinetics. Recycling of glycerol from glycolysis and gluconeogenesis may lead to incompletely labelled tracer molecules. Many existing methods for the measurement of glycerol isotopic enrichment involve the production of glycerol derivatives that result in fragmentation of the glycerol molecule after ionization. It would be favourable to measure the intact tracer molecule since incompletely labelled tracer molecules may be measured as fully labelled. The number of methods available to measure the intact tracer in biological samples is limited. The aim of this project was to develop a gas chromatography/mass spectrometry (GC/MS) method for glycerol enrichment that measures the intact glycerol backbone and is suitable for electron ionization (EI), which is widely available. A previously published method for N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide (MTBSTFA) derivatization was significantly improved; we produced a stable derivative and increased recovery 27-fold in standards. We used the optimized MTBSTFA method in VLDL-triglyceride and found that further modification was required to take matrix effects into account. We now have a robust method to measure glycerol isotopic enrichment by GC/EI-MS that can be used to rule out the known problem of tracer recycling in studies of VLDL kinetics. Copyright (c) 2010 John Wiley & Sons, Ltd.
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11.
  • Adiels, Martin, 1976, et al. (författare)
  • Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity.
  • 2012
  • Ingår i: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 222:1, s. 222-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To better understand the postprandial clearance of triglyceride-rich lipoproteins (TRLs) and its relation to the fasting kinetics of TRLs. Methods Two studies were performed on 30 male subjects: a fasting kinetic study to determine the fasting secretion and clearance rates of apolipoprotein B (apoB) 100 and triglycerides in the very low-density lipoprotein 1 and 2 (VLDL1 and VLDL2) fractions; and a postprandial study to determine the postprandial accumulation of apoB48, apoB100 and triglycerides in the chylomicron, VLDL1 and VLDL2 fractions. Results from these two studies were combined to characterize the postprandial clearance of TRLs in a physiologically relevant setting. Results Our results show that postprandial accumulation of the apoB48-carrying chylomicrons can be predicted from the clearance capacity of the lipolytic pathway, determined in the fasting state. Furthermore, we show that chylomicrons and VLDL1 particles are not cleared equally by the lipoprotein lipase pathway, and that chylomicrons seem to be the preferred substrate. Subjects with a rapid fasting lipid metabolism accumulate lower levels of postprandial triglycerides with less accumulation of apoB100 in the VLDL1 fraction and a faster transfer of apoB100 into the VLDL2 fraction. In contrast, fasting VLDL1 secretion does not predict postprandial triglyceride accumulation. Conclusions Non-fasting triglyceride levels have recently been identified as a major predictor of future cardiovascular events. Here we show that the capacity of the lipolytic pathway is a common determinant of both the fasting and non-fasting triglyceride levels and may thus play an important role in the development of dyslipemia and atherosclerosis.
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12.
  • Andersson, Ida, 1982-, et al. (författare)
  • Kommunala strategier för strategisk planering
  • 2019
  • Ingår i: Samhällsplaneringens teori och praktik. - Stockholm : Liber. - 9789147113613 ; , s. 127-135
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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15.
  • Aspholm, Marina, et al. (författare)
  • Helicobacter pylori adhesion to carbohydrates
  • 2006
  • Ingår i: Methods in Enzymology. - 0076-6879 .- 1557-7988. ; 417, s. 293-339
  • Tidskriftsartikel (refereegranskat)abstract
    • Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.
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16.
  • Aspholm, Marina, et al. (författare)
  • SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans.
  • 2006
  • Ingår i: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374 .- 1553-7366. ; 2:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Adherence of Helicobacter pylori to inflamed gastric mucosa is dependent on the sialic acid-binding adhesin (SabA) and cognate sialylated/fucosylated glycans on the host cell surface. By in situ hybridization, H. pylori bacteria were observed in close association with erythrocytes in capillaries and post-capillary venules of the lamina propria of gastric mucosa in both infected humans and Rhesus monkeys. In vivo adherence of H. pylori to erythrocytes may require molecular mechanisms similar to the sialic acid-dependent in vitro agglutination of erythrocytes (i.e., sialic acid-dependent hemagglutination). In this context, the SabA adhesin was identified as the sialic acid-dependent hemagglutinin based on sialidase-sensitive hemagglutination, binding assays with sialylated glycoconjugates, and analysis of a series of isogenic sabA deletion mutants. The topographic presentation of binding sites for SabA on the erythrocyte membrane was mapped to gangliosides with extended core chains. However, receptor mapping revealed that the NeuAcalpha2-3Gal-disaccharide constitutes the minimal sialylated binding epitope required for SabA binding. Furthermore, clinical isolates demonstrated polymorphism in sialyl binding and complementation analysis of sabA mutants demonstrated that polymorphism in sialyl binding is an inherent property of the SabA protein itself. Gastric inflammation is associated with periodic changes in the composition of mucosal sialylation patterns. We suggest that dynamic adaptation in sialyl-binding properties during persistent infection specializes H. pylori both for individual variation in mucosal glycosylation and tropism for local areas of inflamed and/or dysplastic tissue.
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17.
  • Azevedo, M, et al. (författare)
  • Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype
  • 2008
  • Ingår i: Journal of Pathology. - : Wiley. - 0022-3417 .- 1096-9896. ; 215:3, s. 308-316
  • Tidskriftsartikel (refereegranskat)abstract
    • Helicobacter pylori (Hp) infects half the world's population and causes diverse gastric lesions, from gastritis to gastric cancer. Our aim was to evaluate the significance of secretor and Lewis status in infection and in vitro adherence by Hp expressing BabA adhesin. We enrolled 304 Hp-infected individuals from Northern Portugal. Gastric biopsies, blood and saliva were collected. Polymerase chain reaction (PCR) and immunofluorescence were used to detect BabA+ Hp in gastric biopsies. In vitro adherence by a BabA expressing Hp strain to gastric biopsies was performed. Secretor status was identified by Ulex, a lectin that recognizes secretor-dependent glycan structures in saliva and in gastric mucosa, and by Lewis(a/b) antibodies, and indirectly by identification of an inactivating mutation in the FUT2 gene (G428A). BabA status of infecting Hp was associated with CagA and VacAs1 (p < 0.05), intercellular localization of Hp (p < 0.01) and the presence of intestinal metaplasia (p < 0.05) and degenerative alterations (p < 0.005) in the biopsies. BabA was associated (p < 0.05) with Ulex staining of gastric biopsies and, although not significantly, to absence of homozygosity for FUT2 G428A inactivating polymorphism. In vitro Hp adherence was higher in cases wild-type or heterozygous for FUT2 G428A mutation (p < 0.0001), cases staining for Ulex (p < 0.0001) and a(-)b+ and a(-)b(-) secretor phenotypes (p < 0.001). In conclusion, BabA+ Hp infection/adhesion is secretor-dependent and associated with the severity of gastric lesions.
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18.
  • Benrick, Anna, 1979, et al. (författare)
  • A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
  • 2008
  • Ingår i: Regulatory peptides. - : Elsevier BV. - 0167-0115. ; 146:1-3, s. 189-96
  • Tidskriftsartikel (refereegranskat)abstract
    • Inflammation is a key component in the development of atherosclerosis, and myocardial infarction (MI); therefore we investigated the association between an interleukin-6 signal transducer (IL6ST)/gp130 polymorphism, gp130 function and risk of MI. Structural modeling suggested that a non-conservative single nucleotide polymorphism in the gp130, Gly148Arg, can change the stability and functional properties of the molecule. In vitro studies were done with BAF/3 cells lacking endogenous gp130. Cells stably transfected with the gp130 148Arg variant proliferated less and showed slightly lower STAT-3 phosphorylation in response to gp130 stimulation as compared to cells transfected with gp130 148Gly. In a prospectively followed hypertensive cohort we identified 167 patients who suffered a MI during the study and compared them to matched controls (mean age 57 years, 73% males, n=482). Carriers of the 148Arg variant (f(Arg)=0.12) of the gp130 receptor had decreased odds ratio for MI in univariate analysis (0.56, 95% CI 0.34-0.91, p=0.02). In conclusion, a genetically determined structural variant of the IL-6 receptor subunit gp130 is, independently of other known risk factors, associated with decreased risk of MI. The variant is also associated with decreased IL-6 responsiveness and could lead to a configuration change in the gp130 receptor.
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19.
  • Besse, Lenka, et al. (författare)
  • Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple myeloma
  • 2021
  • Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 81, s. 4581-4593
  • Tidskriftsartikel (refereegranskat)abstract
    • The HIV-protease inhibitor nelfinavir has shown broad anticancer activity in various preclinical and clinical contexts.In patients with advanced, proteasome inhibitor (PI)-refractory multiple myeloma, nelfinavir-based therapy resulted in 65% partial response or better, suggesting that this may be a highly active chemotherapeutic option in this setting.The broad anticancer mechanism of action of nelfinavir implies that it interferes with fundamental aspects of cancer cell biology.We combined proteome-wide affinity-purification of nelfinavir-interacting proteins with genome-wide CRISPR/Cas9-based screening to identify protein partners that interact with nelfinavir in an activity-dependent manner alongside candidate genetic contributors affecting nelfinavir cytotoxicity.Nelfinavir had multiple activity-specific binding partners embedded in lipid bilayers of mitochondria and the endoplasmic reticulum.Nelfinavir affected the fluidity and composition of lipid-rich membranes, disrupted mitochondrial respiration, blocked vesicular transport, and affected the function of membrane-embedded drug efflux transporter ABCB1, triggering the integrated stress response.Sensitivity to nelfinavir was dependent on ADIPOR2, which maintains membrane fluidity by promoting fatty acid desaturation and incorporation into phospholipids.Supplementation with fatty acids prevented the nelfinavir-induced effect on mitochondrial metabolism, drug-efflux transporters, and stress-response activation.Conversely, depletion of fatty acids/cholesterol pools by the FDAapproved drug ezetimibe showed a synergistic anticancer activity with nelfinavir in vitro.These results identify the modification of lipid-rich membranes by nelfinavir as a novel mechanism of action to achieve broad anticancer activity, which may be suitable for the treatment of PI-refractory multiple myeloma.
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20.
  • Björnham, Oscar, 1976-, et al. (författare)
  • Dynamic force spectroscopy of the Helicobacter pylori BabA-Lewis b binding
  • 2009
  • Ingår i: Biophysical Chemistry. - Amsterdam : Elsevier. - 0301-4622 .- 1873-4200. ; 143:1-2, s. 102-105
  • Tidskriftsartikel (refereegranskat)abstract
    • The binding strength of the Helicobacter pylori adhesin–receptor complex BabA-ABO/Lewis b has been analyzed by means of dynamic force pectroscopy. High-resolution measurements of rupture forces were performed in situ on single bacterial cells, expressing the high-affinity binding BabA adhesin, by the use of force measuring optical tweezers. The resulting force spectra revealed the mechanical properties of a single BabA–Leb bond. It was found that the bond is dominated by one single energy barrier and that it is a slipbond. The bond length and thermal off-rate were assessed to be 0.86±0.07 nm and 0.015±0.006 s−1, respectively.
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21.
  • Björnham, Oscar, 1976-, et al. (författare)
  • Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers
  • 2005
  • Ingår i: Journal of Biomedical Optics. - Bellingham, WA : SPIE-Intl Soc Optical Eng. - 1083-3668 .- 1560-2281. ; 10:4, s. 044024-044032
  • Tidskriftsartikel (refereegranskat)abstract
    • Helicobacter pylori is a world-wide spread bacterium that causes persistent infections and chronic inflammations that can develop into gastritis and peptic ulcer disease. It expresses several adhesin proteins on its surface that bind to specific receptors in the gastric epithelium. The most well-known adhesin is BabA, which has previously been shown to bind specifically to the fucosylated blood group antigen Lewis b (Leb). The adhesion forces between BabA and the Leb antigen are investigated in this work and assessed by means of optical tweezers. A model system for in situ measurements of the interaction forces between individual bacteria and beads coated with Leb is developed. It is found that the de-adhesion force in this model system, measured with a loading rate of ~100 pN/s, ranges from 20 to 200 pN. The de-adhesion force appears predominantly as multiples of an elementary force, which is determined to 25±1.5 pN and identified as the unbinding force of an individual BabA-Leb binding. It is concluded that adhesion in general is mediated by a small number of bindings (most often 1 to 4) despite that the contact surface between the bacterium and the bead encompassed significantly more binding sites.
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22.
  • Boren, Jan, et al. (författare)
  • The molecular mechanism for the genetic disorder familial defective apolipoprotein B100
  • 2001
  • Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 276:12, s. 9214-9218
  • Tidskriftsartikel (refereegranskat)abstract
    • Familial defective apolipoprotein B100 (FDB) is a genetic disorder in which low density lipoproteins (LDL) bind defectively to the LDL receptor, resulting in hypercholesterolemia and premature atherosclerosis. FDB is caused by a mutation (R3500Q) that changes the conformation of apolipoprotein (apo) B100 near the receptor-binding site. We previously showed that arginine, not simply a positive charge, at residue 3500 is essential for normal receptor binding and that the carboxyl terminus of apoB100 is necessary for mutations affecting arginine 3500 to disrupt LDL receptor binding. Thus, normal receptor binding involves an interaction between arginine 3500 and tryptophan 4369 in the carboxyl tail of apoB100. W4369Y LDL and R3500Q LDL isolated from transgenic mice had identically defective LDL binding and a higher affinity for the monoclonal antibody MB47, which has an epitope flanking residue 3500. We conclude that arginine 3500 interacts with tryptophan 4369 and facilitates the conformation of apoB100 required for normal receptor binding of LDL. From our findings, we developed a model that explains how the carboxyl terminus of apoB100 interacts with the backbone of apoB100 that enwraps the LDL particle. Our model also explains how all known ligand-defective mutations in apoB100, including a newly discovered R3480W mutation in apoB100, cause defective receptor binding.
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23.
  • Borén, Thomas, et al. (författare)
  • A brief review of regulation for creative and cultural industries
  • 2021
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • This report examines key elements of the European regulatory environment for the cultural and creative industries (CCI) and is part of Work Package 3 (Policy, regulatory and governance matrix of the CCI in Europe) of the CICERONE‐project (Creative Industries Cultural Economy Production Network, Grant No.: 822778). The focus of the report is on regulation within the EU that effect CCIs and their production networks and does not specifically address the myriad ways in which trade regulations and regulators effect CCIs. The perspective is based on the concept of Global Production Networks which suggests that the regulatory environment along the entire value chain of cultural production, and the places involved, needs to be considered together. The regulatory environment covering the CCIs encompasses both policy and legislation as well as it includes frameworks that exist at local, regional, national, EU, and supranational levels. In this report we discuss six key areas: (1) policy hierarchies and scalar and sectorial complexity; (2) regulation of work and contracts, with a focus on small actors and protected designations;( 3) content and production regulation, including notions of quotas, arm‐length’s distance and the new political landscape in Europe; (4) intellectual property rights regulation; (5) competition regulation, monopolies, and platform economies; (6) and regulation for the digital single market. Throughout the report we highlight possibilities that may be considered in policy to further support the CCIs.
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24.
  • Borén, Thomas, 1967-, et al. (författare)
  • Artists and creative city policy : Resistence, the mundane and engagement in Stockholm, Sweden
  • 2017
  • Ingår i: City, Culture and Society. - : Elsevier BV. - 1877-9166 .- 1877-9174. ; 8, s. 21-26
  • Tidskriftsartikel (refereegranskat)abstract
    • Much of the literature around notions of the ’creative class’ and the ‘creative city’ has placed artists as a central, typical creative group. However, that literature has often placed artists in a conceptual dichotomy - either they are seen as uncritical champions of creative city policy (because it boosts their profile and markets) or they are placed in radical opposition to it. This paper explores the attitudes of a sample of artists in Stockholm, Sweden to open this dichotomy up to a more nuanced critique. The analysis considers the diversity of views, attitudes and perceptions of these artists towards creative city policy. While opposition and resistance to the application of creative city policy can certainly be found, the paper seeks to move beyond this to examine how the lack of accord between creative producers and policy-makers can be the outcome of more mundane, everyday practices. In addition, artists join together in specific projects and loose, ephemeral networks to address the issues surrounding the implementation of creative city policy in ways which oppose it but also seek alternatives through engaging planners and the public. Overall the paper calls for an understanding of artists which goes beyond the enthusiast/opponent dichotomy towards developing an understanding of the diverse range of artist responses and engagement with creative city policy.
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25.
  • Borén, Thomas, 1967-, et al. (författare)
  • Artists as planners? Identifying five conceptual spaces for interactive urban development
  • 2017
  • Ingår i: The Impact of Artists on Contemporary Urban Development in Europe. - Cham : Springer. - 9783319532158 - 9783319532172 ; , s. 299-314
  • Bokkapitel (refereegranskat)abstract
    • While artists are often seen as key actors in contemporary urban development, particularly linked with the increased use of culture and creativity in urban development policy, to date they have mainly been considered in only a few limited roles. This chapter explores how artists are engaging with policy-makers and planners in attempts to produce ‘new conceptual spaces’ (Gibson and Klocker 2005) in which urban policy and planning practice becomes a form of knowledge and policy co-production. The chapter explores the dynamics of this interaction to understand its different forms, with a particular focus on how artists inform or affect urban planning imagination. Through the analysis of the state of the art in this field and of a number of projects where artists, policy-makers and planners have interacted in urban development projects we identify and discuss five types of new conceptual spaces for artist-planning interactions. Three of these consider interactions initiated by the formal urban governance structures, whereas two are artist initiated. Taken together these five types represent empirically based alternatives to neo-liberalizing agendas as to how art and artists may realize a more varied role in co-creating the urban future.
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26.
  • Borén, Thomas, et al. (författare)
  • Beringia - en region? : Introduktion till en relationell regionalgeografi.
  • 2008
  • Ingår i: Kring Beringia.. - : SSAG, Stockholm. ; , s. 7-18
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Beringia - en region? är introduktionen till antologin Kring Beringia. Expeditioner och folk. Introduktionen behandlar regionbegreppet, relationella rum och sovjetisk geografi, samt sammanfattar kort de olika kapitelbidragen.
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27.
  • Borén, Thomas (författare)
  • Bonniers uppslagsbok
  • 2007
  • Annan publikation (populärvet., debatt m.m.)abstract
    • I Bonniers uppslagsbok (2007) har författaren skrivit uppslagsorden inom ämnesområdet svensk geografi (från I till Ö).
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29.
  • Borén, Thomas, 1967-, et al. (författare)
  • Conceptual export and theory mobilities : exploring the reception and development of the “creative city thesis” in the post-socialist urban realm
  • 2016
  • Ingår i: Eurasian geography and economics. - : Informa UK Limited. - 1538-7216 .- 1938-2863. ; 57:4-5, s. 588-606
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper addresses the limited contribution of scholarship from within/on the post-socialist urban arena to global urban studies, a phenomenon attributed to the influence of a hegemonic Anglo-American academic complex. We seek to present a more nuanced account by considering scholarship on the “creative city” in a post-socialist context. A numerical analysis of English language publications confirms the lack of impact of scholarship from/on post-socialist areas, though we do identify literature which may be “theory exporting” and emphasize the temporal dimension of the development of scholarship. We then consider the interaction of three global mobilities to present a more nuanced account of this pattern – the “creative city” thesis as globally mobile urban policy, the neoliberalization of universities as a globally mobile restructuring of the context in which these inequalities in knowledge-production are produced, and urban studies theorizing itself as a set of globally mobile concepts and practices. We therefore explore the dynamic interaction of a particular urban phenomenon (“creative city” policy) with academic knowledge production. Adopting this perspective allows us to emphasize other factors such as path dependencies within post-socialist areas and to give due emphasis to agency within the region and how these interact with global processes of neoliberalizing academia.
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30.
  • Borén, Thomas, 1967-, et al. (författare)
  • Culture and creativity in actually existing urban policy
  • 2011
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • In the last decade culture and creativity have become widely adopted as important aspects of urban development strategies. Cities try to make use of their cultural capital in the highly competitive urban system of late capitalism, in order to make themselves attractive for capital investment, skilled labour, tourists and media attention. There is a great deal of debate of these issues and the poster account for the authours' research and projects on these these issues.
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31.
  • Borén, Thomas, 1967- (författare)
  • Exploring the role of place-based knowledge : Insights from local governance practices
  • 2020
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • This report focuses on the role of local knowledge and on place-based knowledge in local governance practices. In order to understand place-based development, the role of place-based knowledge plays an important part. The concept of place-based development is moreover underpinned by a growing discussion in policy research regarding the importance to widen the knowledge base for policy interventions, especially concerning place-based development strategies.The present report is an empirical analyses of a number of key case studies in the RELOCAL project. Using a comparative perspective, the report analyses a) the forms, expressions and way ofmobilizing local and place-based knowledge; b) the learning loops involved and c) and discusses the flexibility and adaptability of the actions in relation to what role local and place-based knowledge has. 
  •  
32.
  • Borén, Thomas, 1967- (författare)
  • Fem år med Geografiska Notiser
  • 2012
  • Ingår i: Geografiska Notiser. - Lund : Geografiska notiser. - 0016-724X. ; 70:1, s. 3-5
  • Tidskriftsartikel (populärvet., debatt m.m.)
  •  
33.
  • Borén, Thomas (författare)
  • Foreword
  • 2018
  • Ingår i: kritisk etnografi. - Stockholm : Svenska Sällskapet för Antropologi och Geografi. - 2003-1173. ; 1:1, s. 5-5
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
  •  
34.
  •  
35.
  • Borén, Thomas, et al. (författare)
  • Geographical studies in Aotearoa 2006 : Report from a geographical field course in New Zealand, March 2006.
  • 2007
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Rapporten innehåller sju stycken uppsatser av studenter på påbyggnadskursen (C-kursen) i Geografi vid Stockholms universitet. Samtliga uppsatser är baserade på eget fältarbete i Queenstown och Wanaka, Nya Zeeland, i mars 2006. Temat för uppsatserna varierar och de behandlar: urbana strukturer, platsidentitet, platskänsla, vingårdar och vinturism, ekoturism, äventyrsturism, samt migration mellan små städer. Uppsatserna föregås av en kort introduktion på engelska om geografiprogrammets exkursioner och fältkurser av Thomas Borén, Anders Fridfeldt, Peter Kinlund och Britta Sannel.
  •  
36.
  • Borén, Thomas, 1967-, et al. (författare)
  • Getting Creative with the ‘Creative City’? : Towards New Perspectives on Creativity in Urban Policy
  • 2013
  • Ingår i: International Journal of Urban and Regional Research. - : Wiley. - 0309-1317 .- 1468-2427. ; 37:5, s. 1799-1815
  • Tidskriftsartikel (refereegranskat)abstract
    • This article explores new avenues for academic research on the ‘creative city’. Creativity offers opportunities for urban development and the personal development of urban inhabitants, but its adoption in urban policy is frequently criticized for being welded to economic imperatives and a neoliberal agenda. Urban policymakers worldwide continue to adopt narrow conceptualizations of ‘creativity’ while largely ignoring extensive academic criticism of the concept, suggesting that academic concerns with creativity in urban policy need to be reoriented more effectively. This article develops four key theoretical points on the ‘creative city’ and creative urban policy. It argues that the focus of enquiry should shift towards a more in-depth understanding of how ‘creativity’ is constructed, contested and performed in specific urban contexts, understanding the ‘creative policy gap’ between policymakers and those engaged in all kinds of creative practice, and developing forms of artistic intervention to attempt to make creative policymaking more inclusive and ‘creative’. These points are developed through a critique of the literature and some illustrative examples of people in creative occupations interacting with urban planners and policymakers in creative interventions.
  •  
37.
  •  
38.
  •  
39.
  •  
40.
  • Borén, Thomas (författare)
  • Hur ska vi rädda centrum? : forskare analyserar
  • 2008
  • Annan publikation (populärvet., debatt m.m.)abstract
    • Artikeln ställer två platsbegrepp mot varandra och argumenterar för att planeringsfrågor som rör Hökarängens centrum med fördel kan lösas genom att arbeta i samhällsprocessernas riktning vad gäller rörlighetens utveckling i det senmoderna samhället. Argumentet tar analytisk sats i ett relationellt platsbegrepp.
  •  
41.
  •  
42.
  •  
43.
  • Borén, Thomas, 1967-, et al. (författare)
  • Intra-urban connectedness, policy mobilities and creative city-making : national conservatism vs. urban (neo)liberalism
  • 2020
  • Ingår i: European Urban and Regional Studies. - : SAGE Publications. - 0969-7764 .- 1461-7145. ; 27:3, s. 246-258
  • Tidskriftsartikel (refereegranskat)abstract
    • This article aims to advance the literature on policy mobility by decentring the primacy of mobility itself and focusing on understanding what cities do in order to ‘arrive at’ localized versions of urban policy in relation to globally circulating ideas around creativity. The paper explores the performance of a particular local ‘creative economy’ in terms of institutional and strategic adjustments, key drivers and individuals and events, and the role of long-term local, national and international influences on ‘creative cityness’. It does this through an analysis of cultural and creativity policy and local stakeholders in the cultural policy scene in Gdańsk, Poland, focusing on the local performative aspects of mobile policies and arguing the need to understand the formation of a ‘common local project’ as a form of intra-urban connectedness alongside inter-urban connectedness. The paper extends the range of contexts in which the ‘creative city’ has been analysed to include post-socialist, post-European Union accession Central and Eastern Europe, thus making an original contribution by studying these issues in the context of the complex multi-scalar relations between the city, national government and the supranational European Union and the ideological conflict between national authoritarian neoliberalism and urban and supranational scale (neo-)liberalism.
  •  
44.
  • Borén, Thomas, et al. (författare)
  • Introduction
  • 2007
  • Ingår i: Geographical studies in Aotearoa 2006. - Stockholm : Kulturgeografiska inst. & Naturgeografiska inst., Stockholms universitet. ; , s. 1-4
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • A short introduction to the excursions and fieldwork that are part of the Advanced level Geography courses at Stockholm University. After the introduction follows seven bachelor theses in Geography, empirically based on fieldwork in Wanaka and Queenstown, New Zealand, March 2006.
  •  
45.
  • Borén, Thomas, 1967- (författare)
  • Introduktion - urban utveckling och interaktion
  • 2017
  • Ingår i: Urban utveckling och interaktion. - Stockholm : Svenska sällskapet för antropologi och geografi. - 9789198215038 ; , s. 7-24
  • Bokkapitel (refereegranskat)
  •  
46.
  • Borén, Thomas, et al. (författare)
  • Knowledge and place-based development – towards networks of deep learning
  • 2022
  • Ingår i: European Planning Studies. - : Informa UK Limited. - 0965-4313 .- 1469-5944. ; 30:5, s. 825-842
  • Tidskriftsartikel (refereegranskat)abstract
    • The influential work by Barca on place-based development, which has permeated policy and academic discourses alike in recent years, builds on the premise that localities are expected to utilize their endogenous potential rather than placing their trust in redistributive policies. This endogenous potential involves local knowledge and place-based knowledge, and how these two types can tap into actions. This has barely been explored in a systematic and comparative manner. This paper therefore examines 20 urban and rural development actions across Europe in order to understand how, and the extent to which, local knowledge and place-based knowledge are mobilized (or not). It makes use of empirically informed evidence to identify evolving mechanisms and to analyse how learning loops are triggered. We argue that it is crucial for leading actors in such development actions to pay attention to these different mechanisms of mobilizing these two types of knowledge and how to trigger learning loops. Since this analysis also highlights a number of shortcomings and inhibitors regarding the extent to which these collective knowledge and learning capacities actually inform actions over time, the concept of ‘networks of deep learning’ is suggested as a knowledge management principle for key actors in local governance.
  •  
47.
  •  
48.
  •  
49.
  • Borén, Thomas, 1967- (författare)
  • Meeting-places of transformation : urban identity, spatial representations and local politics in post-Soviet St Petersburg
  • 2009
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • This study develops a model for understanding spatial change and the construction of space as a meeting-place, and then employs it in order to show an otherwise little-known picture of (sub-)urban Russia and its transformation from Soviet times to today. The model is based on time-geographic ideas of time-space as a limited resource in which forces of various kinds struggle for access and form space in interaction with each other. Drawing on cultural semiotics and the concepts of lifeworld and system, the study highlights the social side of these space-forming forces. Based on a long-term fieldwork (participant observation) in Ligovo/Uritsk, a high-rise residential district developed around 1970 and situated on the outskirts of Sankt-Peterburg (St Petersburg), the empirical material concerns processes of urban identity, spatial representations and local politics. The study explicates three codes used to form the image of the city that all relate to its pre-Revolutionary history, two textual strategies of juxtaposition in creating the genius loci of a place, and a discussion of what I call Soviet "stiff landscape" in relation to Soviet mental and ordinary maps of the urban landscape. Moreover, the study shows that the newly implemented self-governing municipalities have not realised their potential as political actors in forming local space, which raises questions on the democratisation of urban space. Finally, the study argues that the model that guides the research is a tool that facilitates the application of the world-view of time-geography and the epistemology of the landscape of courses in concrete research. The study ends with an attempt to generalise spatial change in four types.
  •  
50.
  • Borén, Thomas, et al. (författare)
  • Metropolitan Processes in Post-Communist States : An Introduction
  • 2007
  • Ingår i: Geografiska Annaler Series B: Human Geography. - 0435-3684. ; 89B:2, s. 95-110
  • Tidskriftsartikel (refereegranskat)abstract
    • This introductory article identifies and discuss five key legacy aspects of post-Communism for the urban geography of Eastern and Central Europe. These are concerned with (1) central planning, (2) land allocation, (3) the second economy, (4) defence considerations, and (5) the implications of the ideological leadership of the communist parties. The discussion is based on the existing literature and on the five articles in this theme issue. The introduction ends with proposing a general evolutionary model for suburbanisation, and with some suggestions for further research within the field of post-Communist urban geography.
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