| 1. |
- Andersson, Ingvar B., et al.
(författare)
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Återförsurning av sjöar : Observerade och förväntade biologiska och kemiska effekter
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport är en översiktlig genomgång av de idag tillgängliga, delvis publicerade, experimentella erfarenheterna av kemiska och biologiska effekter vid återförsurning i ytvatten där kalkning avbrutits. Sammanställningen har genomförts i avsikt att bredda kunskapsunderlaget för diskussioner om tänkbara effekter i samband med att kalkningen upphör i vissa ytvatten. Som bakgrundsdokument är dessutom en litteraturöversikt bifogad, vilken även inkluderar övrig litteratur rörande försurning - kalkning som kan anses ha en viss allmän relevans för kunskapsläget avseende återförsurning av kalkade vatten (se Appendix). Resultatet från hittills genomförda fältstudier av återförsurning, endast tre stycken av någon större omfattning i Sverige, visade att stora förändringar inträdde snabbt. Utvecklingen gick mot förhållanden liknande de i det sura tillståndet, med både negativ utveckling av ekosystemet och en påtaglig haltökning av aluminium m.fl. metaller i vattnet. Experimentell försurning av vattnet över sedimentproppar visade att tidigare deponerade metaller kan lösas ut från sedimenten. De hittills genomförda återförsurningsstudierna utfördes mestadels i gravt försurningsskadade sjöar, i ett fall också efter relativt kortvarig kalkning, och kan därför vara ett otillräckligt underlag för att kunna generalisera de effekter som kan uppstå vid återförsurning av kalkade sjöar. Många av de observerade biologiska förändringarna sammanfaller med vad som generellt observerats i samband med försurning av sjöar men vissa biologiska förändringar var dock avvikande och i några fall av delvis oväntad natur. Omfattningen och hastigheten i de senare fallen indikerade att de aktuella organismsamhällena saknade vissa reglerande mekanismer (interaktioner) och därför genomgick en utveckling präglad av instabilitet under återförsurningen. Det sura svavelnedfallet har minskat med ca. 60 % sedan 70-talet vilket medfört en proportionell återhämtning av vattenkemi och även biota i vissa ytvatten inom regioner som haft kortvarigt eller litet överskridande av den kritiska försurningsbelastningen (ringa markförsurning). Däremot har den minskade belastningen på ytvattnen hittills resulterat i små positiva förändringar inom de mest försurade områdena i södra Sverige. Trots en halvering av sulfathalt och surhet i många sjöar och vattendrag, har få biologiska förändringar observerats, då pH värden <5 och toxiska aluminiumhalter fortfarande medför negativa effekter på de flesta känsliga organismer. Modellsimuleringar har visat att återhämtningen inom sådana områden kommer att ta mycket lång tid (10- tals till kanske 100 år) eftersom försurningen av marken varit omfattande. Inom dessa områden, med en låg kritisk belastningsgräns, krävs ytterligare reduktion av belastningen samt i vissa fall t.o.m. kompletterande åtgärder som markkalkning. Även depositionen av flera tungmetaller har minskat kraftigt under de senaste decennierna, särskilt den långdistanstransporterade andelen, men hur stora förändringar detta medfört på ytvattnens innehåll av tungmetaller är i dagsläget osäkert, eftersom längre tidsserier från skogssjöar saknas inom miljöövervakningen.Av de kalkade sjöarna i Sverige, ca. 7500 st, beräknas mer än 1700 sjöar kunna få pHvärden under 5,4 och förlora alkaliniteten om kalkningar upphör i nuläget. De flesta sjöarna som kan komma att återförsuras till pH-värden under 5,4 är belägna inom de områden i sydvästra Sverige som är mest försurningsskadade. Stoppad kalkning i dessa sjöar skulle medföra långtgående återförsurning inom en tidsrymd av ca. 2 - 3 gånger den teoretiska omsättningstiden, för många sjöar motsvarande 3 till 9 år. Sannolikt skulle många av de effekter som observerats i de här genomgångna återförsurningsstudierna uppstå. Även sjöar som skulle återförsuras till pH-värden mellan 5,4 och 6,0 kan riskera att få skador på populationer av känsligare arter. Drygt 4000 sjöar skulle få pH-värden under 6,0 vid en stoppad kalkning. I sjöar med från början måttlig försurning kan en återförsurning förväntas resultera i tämligen marginella eller inga effekter med hänsyn till minskad försurningsbelastning och ringa markförsurning. Denna grupp omfattar en del av de ca. 3500 sjöar som åtminstone på längre sikt inte skulle riskera att få pH-värden <6,0 vid en stoppad kalkning. I de flesta sådana fall skulle endast de allra känsligaste arternas populationer riskera att påverkas. Surstötar, d.v.s. episodisk tillförsel av markant surare vatten i samband med kraftiga regn, snösmältning eller efter längre torrperioder, utgjorde i försurningens inledningsskede en viktig faktor för uppkomsten av biologiska skador eftersom särskilt höga halter av toxiskt oorganiskt aluminium förekom i samband med sådana situationer. Sannolikt kan surstötarna utgöra ett betydande problem även under återhämtningsfasen, då risk föreligger för fortsatta utflödena av höga aluminiumhalter i många sjöar och framförallt vattendrag inom de områden där markförsurningen kvarstår länge varvid en positiv biologisk utveckling kommer att motverkas. Problem kan även fortsättningsvis uppträda inom vissa nordligare lågbelastade regioner där främst hydrologiska faktorer samt kraftiga utflöden av organiska syror bidrar till uppkomsten av surstötar med inflöden av förhöjda halter av aluminium. Högre halter av komplexbildande organiska anjoner kan dock i sådana fall bidra till en lägre toxisk effekt. I denna rapport föreslås en översyn av kalkningsverksamheten, liksom rekommendationer av urvalskriterier för olika ytvatten om det blir aktuellt med åtgärder som medför en minskad kalkning. Slutligen föreslås forskningsinsatser för att belysa en del av de oklarheter som för närvarande råder om effekterna i samband med återförsurning.
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| 2. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 3. |
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| 4. |
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| 5. |
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| 6. |
- Ahlqvist, Jan, Birger, 1952-, et al.
(författare)
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Osseointegrated implants in edentulous jaws: a 2-year longitudinal study.
- 1990
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Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786 .- 1942-4434. ; 5:2, s. 155-163
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Tidskriftsartikel (refereegranskat)abstract
- Osseointegrated implants in 50 edentulous jaws were studied during a 2-year observation period. The implant survival rate was 89% in the maxillae and 97% in the mandibles. The marginal bone loss averaged 1.7 mm in the maxillae and 1.1 mm in the mandibles. Most of this bone loss occurred during the first year. The bone loss was greater in jaws with a preoperatively minor resorption of the alveolar ridge than in those with moderate or advanced resorption. The bone loss was also greater at the medially positioned implants than at those more posterior.
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| 7. |
- Andersson, Niklas, et al.
(författare)
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Model-Based Comparison of Batch and Continuous Preparative Chromatography in the Separation of Rare Earth Elements
- 2014
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Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 0888-5885 .- 1520-5045. ; 53:42, s. 16485-16493
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Tidskriftsartikel (refereegranskat)abstract
- The demand for rare earth elements (REEs) is growing, while the future supply is uncertain. Their unique electronic characteristics make them irreplaceable, and the commercial value of pure fractions is high. A model-based simulation study is presented that compares batch chromatography with the twin-column MCSGP (multicolumn countercurrent solvent gradient purification) process for ion-exchange chromatography of the four-component system neodymium, samarium, europium, and gadolinium. The last three components are considered products with individual purity requirements of 99%. The twin-column process has been shown to be a good alternative to the batch process regarding modifier consumption and productivity since it enables internal recycling to achieve high purities. A new cut strategy for MCSGP is applied where subfractions are taken from each outlet. Two multiobjective optimizations with yield, solvent productivity, and productivity objectives show that the MCSGP process is a better alternative than batch chromatography.
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| 8. |
- Andrén, Cecilia M., 1964-
(författare)
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Toxicity of Inorganic Aluminium in Humic Streams
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aluminium (Al) has been recognised as a main toxic factor alongside pH in acidified water ecosystems. The toxic effect of Al has been attributed to inorganic Al (Ali), though there are few in situ studies in ambient humic waters which are the focus of this thesis.The aim was to estimate Ali toxicity and thus also Ali concentrations in Swedish humic streams. Subsequently it is necessary to analyse Ali correctly, which was studied by modelling and method intercalibrations. The hypothesis was that the effect of Ali could be followed via physiological effects and Al accumulation, as well as by mortality. Toxicity was studied by in stream exposures of brown trout (Salmo trutta L.) and two salmonid prey organisms (Gammarus pulex and Baetis rhodani) during spring flood.The modelling of the Ali fraction was performed using monitoring data covering all of Sweden with satisfactory results. The essential variables for Ali modelling were determined; Al, DOC, pH and F, while Fe, Ca and Mg had less effect. The automated analytical procedure for Ali (with cation exchange followed by complexation with pyrocatechol violet) was modified and validated and showed to be the preferred method for laboratory analyses.To avoid detrimental effects for brown trout Ali should be <20 µg/L and pH >5.0; mortality was high when the Ali was above 50 µg/L. The invertebrates were more sensitive, as mortalities occurred at pH <6.0 and Ali >15 µg/L for G. pulex, and at pH <5.7 and Ali >20 µg/L for B. rhodani. It is prudent to use a wide view and let the most sensitive species set the tolerance limits; a pH above 5.7-6.0 and Ali below 15-20 µg/L allows the stream ecosystems to thrive.Today, as waters are recovering from acidification, the aim of mitigating liming is to carefully adjust dosage to avoid suboptimal water quality. The thresholds found in this thesis can be used to efficiently but carefully decrease liming, as both Ali and pH levels have to be balanced to sustain the recovering aquatic biota.
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| 9. |
- Antoniou, Antonis C., et al.
(författare)
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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
- 2011
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 20:16, s. 3304-3321
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Tidskriftsartikel (refereegranskat)abstract
- Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
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| 10. |
- Bakhtadze, Ekaterine, et al.
(författare)
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Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients
- 2008
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 51:12, s. 2224-2232
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Tidskriftsartikel (refereegranskat)abstract
- Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diabetes in young (15-34 years) and middle-aged (40-59 years) diabetic patients. In 1,642 young and 1,619 middle-aged patients we determined: (1) HLA-DQB1 genotypes; (2) PTPN22 and INS variable-number tandem repeat (VNTR) polymorphisms; (3) two single nucleotide polymorphisms (rs7903146 and rs10885406) in the TCF7L2 gene; (4) glutamic acid decarboxylase (GAD) and IA-2-protein tyrosine phosphatase-like protein (IA-2) antibodies; and (5) fasting plasma C-peptide. Frequency of risk genotypes HLA-DQB1 (60% vs 25%, p =9.4x10(-34); 45% vs 18%, p= 1.4x10(-16)), PTPN22 CT/TT (34% vs 26%, p=0.0023; 31% vs 23%, p=0.034), INS VNTR class I/I (69% vs 53%, p=1.3x10(-8); 69% vs 51%, p=8.5x10(-5)) and INS VNTR class IIIA/IIIA (75% vs 63%, p=4.3x10(-6); 73% vs 60%, p=0.008) was increased in young and middle-aged GAD antibodies (GADA)-positive compared with GADA-negative patients. The type 2 diabetes-associated genotypes of TCF7L2 CT/TT of rs7903146 were significantly more common in young GADA-negative than in GADA-positive patients (53% vs 43%; p=0.0004). No such difference was seen in middle-aged patients, in whom the frequency of the CT/TT genotypes of TCF7L2 was similarly increased in GADA-negative and GADA-positive groups (55% vs 56%). Common variants in the TCF7L2 gene help to differentiate young but not middle-aged GADA-positive and GADA-negative diabetic patients, suggesting that young GADA-negative patients have type 2 diabetes and that middle-aged GADA-positive patients are different from their young GADA-positive counterparts and share genetic features with type 2 diabetes.
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| 11. |
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| 12. |
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| 13. |
- Bergqvist, Jenny, et al.
(författare)
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Quantitative real-time PCR analysis and microarray-based RNA expression of HER2 in relation to outcome
- 2007
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:5, s. 845-850
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Our aim was to use quantitative real-time PCR (Q-PCR) and RNA expression profiles (RNA-EPs) to investigate HER2 status in relation to outcome. PATIENTS AND METHODS: Cut-off levels for Q-PCR and RNA-EP were established in relation to immunohistochemistry (IHC) validated by FISH in a test set of frozen tissue samples from 40 primary breast cancers. The HER2 status was subsequently studied in another validation set of 306 tumors, where Q-PCR and RNA-EP results were compared with previously carried out IHC that we had validated by chromogenic in situ hybridization (CISH). RESULTS: Q-PCR and RNA-EP offered similar sensitivity (90% versus 77%), specificity (93% versus 95%), and negative (99% versus 98%) and positive (63% versus 61%) predictive values for HER2 determinations. Analyses of relapse-free survival (RFS) and overall survival on the basis of 5 and 10 years of follow-up indicated equivalent hazard ratios for all three techniques. In contrast to IHC/CISH, both Q-PCR and RNA-EP analyses of HER2 also gave statistically significant results regarding RFS and breast cancer-corrected survival after 10 years of follow-up. CONCLUSION: The use of RNA-EP and Q-PCR to analyze HER2 in frozen and formalin-fixed breast cancer samples may be an alternate approach to IHC in combination with FISH/CISH.
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| 14. |
- Bertills, Ulla, et al.
(författare)
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Biologiska effekter av Exanter
- 1986
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I syfte att belysa miljöeffekterna av xantater, som används som flotationsreagens vid anrikning av sulfidmalmer, genomfördes toxicitetstester med fisk, alger och bakterier (microtox-teknik). De testade kemikalierna var K-etylxantat, Na-isopropylxantat och K-amylxantat. Dessutom testades också kombinationseffekterna med metallerna Zn, Cu, Pb och Cd på alger och fisk, samt xantaternas inverkan på anrikingen av Zn, Cu, Pb, Cd och Hg i fisklever.xantanterna visade sig vara mycket toxiska för alger och bakterier ( EC50-värden på 25-650µg/l) med mindre giftiga för fisk (lax, 4d LC50=11000-65000 µg/l) En mycket kraftig ökning av metallernas akuta giftverkan i kombination med xanter konstaterades. För fisk var potentieringsgraden upp till 25 gånger och för alger upp til 3,5 gånger, jämfört med ämnenas adderade effekter. Etyl och isobutyl-xantat medförde den kraftigaste potentieringen. Exponeringen för xantat medförde vidare att anrikningen av bly i fisklever ökade med upp till åtta gånger.
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| 15. |
- Bignert, Anders, et al.
(författare)
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Övervakning av metaller och organiska miljögifter i marin biota, 2011
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The environmental toxicants examined in this report can be classified into five groups –heavy metals, chlorinated compounds, brominated flame retardants, polyaromatichydrocarbons and perfluorinated compounds. Each of these contaminants has beenexamined from various sites for up to six different fish species, in blue mussels, and inguillemot eggs, for varying lengths of time. The following summary examines overalltrends, spatial and temporal, for the five groups.Condition and Fat ContentCondition and fat content in different species tended to follow the same pattern at the samesites, with a few exceptions. Most of the fish species generally displayed a decreasing trendin both condition and fat content at most sites examined. Exceptions to this were increasesin fat content seen in herring (the last ten years) and cod at Fladen; an increase in conditionfor herring at Ängskärsklubb in spring; and in perch, a decrease in fat content atKvädöfjärden but no trend in condition for the same site.Heavy MetalsDue to a change in methods for metal analysis (not Hg) in 2004, values between 2003 and2007 should be interpreted with care. From 2009 metals are analyzed at ITM, Stockholmuniversity.The longer time series in guillemot egg and spring-caught herring from the southernBothnian Sea and southern Baltic Proper show significant decreases of mercury. Theherring site in the southern Bothnain Sea indicates a local Hg-source. The rest of the timeseries show varying concentrations over the study period, and even increasing trends in e.g.cod muscle and blue mussels, but the concentrations are fairly low compared to measuredconcentrations in perch from fresh water and coastal sites. However, in most cases, theseconcentrations are above the newly suggested EU-target level of 20 ng/g wet weight.Lead is generally decreasing over the study period (in time series of sufficient length),supposedly due to the elimination of lead in gasoline. Elevated lead concentrations between2003 and 2007 (e.g. Harufjärden) should be viewed with caution (see above regardingchange in analysis methods).Cadmium concentrations show varying non-linear trends over the monitored period. It isworth noting that despite several measures taken to reduce discharges of cadmium,generally the most recent concentrations are similar to concentrations measured 30 yearsago in the longer time series.The reported nickel concentrations show no consistent decreasing trends. Some series beginwith two elevated values that exert a strong leverage effect on the regression line and maygive a false impression of decreasing trends. Chromium generally shows decreasing trends,possibly explained by a shift in analytical method. The essential trace metals, copper andzinc, show no consistent trends during the monitored period.
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| 16. |
- Bignert, Anders, et al.
(författare)
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Övervakning av metaller och organiska miljögifter i marin biota, 2012
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The environmental toxicants examined in this report can be classified into five groups –heavy metals, chlorinated compounds, brominated flame retardants, polyaromatichydrocarbons and perfluorinated compounds. Each of these contaminants has beenexamined from various sites for up to six different fish species, in blue mussels, and inguillemot eggs, for varying lengths of time. The following summary examines overalltrends, spatial and temporal, for the five groups.Condition and Fat ContentCondition and fat content in different species tended to follow the same pattern at the samesites, with a few exceptions. Most of the fish species generally displayed a decreasing trendin both condition and fat content at most sites examined. Exceptions to this were increasesin fat content and condition factor seen in cod liver at both sites; an increase in conditionfor herring at Ängskärsklubb in spring; and in perch and eelpout, a decrease in fat content atKvädöfjärden (perch) and Väderöarna (eelpout) but no trend in condition for the same site.Heavy MetalsDue to a change in methods for metal analysis (not Hg) in 2004, values between 2003 and2007 should be interpreted with care. From 2009 metals are analyzed at ITM, StockholmUniversity.The longer time series in guillemot egg and spring-caught herring from the southernBothnian Sea and southern Baltic Proper show significant decreases of mercury. Theherring site in the southern Bothnain Sea indicates a local Hg-source. The rest of the timeseries show varying concentrations over the study period, and even increasing trends in e.g.cod muscle and eelpout muscle from Väderöarna, but the concentrations are fairly lowcompared to measured concentrations in perch from fresh water and coastal sites. However,in most cases, these concentrations are above the newly suggested EU-target level of 20ng/g wet weight.Lead is generally decreasing over the study period (in time series of sufficient length),supposedly due to the elimination of lead in gasoline. Elevated lead concentrationsbetween 2003 and 2007 (e.g. Harufjärden) should be viewed with caution (see aboveregarding change in analysis methods).Cadmium concentrations show varying non-linear trends over the monitored period. It isworth noting that despite several measures taken to reduce discharges of cadmium,generally the most recent concentrations are similar to concentrations measured 30 yearsago in the longer time series.The reported nickel concentrations show no consistent decreasing trends. Some series beginwith two elevated values that exert a strong leverage effect on the regression line and maygive a false impression of decreasing trends. Chromium generally shows decreasing trends,possibly explained by a shift in analytical method. The essential trace metals, copper andzinc, show no consistent trends during the monitored period.
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| 17. |
- Björkvald, Louise, et al.
(författare)
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Influence of landscape type on trace metals in small boreal catchments
- 2007
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Ingår i: Geochimica et cosmochimica acta 71 (15) A95 Suppl. S. Aug 2007. ; , s. A95-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We studied temporal and spatial variations of trace metal (TM) concentrations (As, Cd, Co, Cr, Cu, Ge, La, Ni, Pb, Rb, Sc, and Y) in stream water and their correlation with catchment properties (i.e. coverage of wetland and forest), but also with Fe and Mn. During 2004 and 2005 water samples were collected from 10 streams (0.13 km2 to 67 km2) in the Krycklan Catchment Study, a boreal stream network in northern Sweden. Since spring snowmelt is the most important hydrological event, the monthly sampling was intensified during spring flood (April-May) when samples were collected every second day. Total and dissolved (<0.4µm) concentrations of Fe and Mn were determined by ICP-OES. Dissolved concentrations of TM were determined by ICP-MS.Preliminary results show a seasonal variation for all TM, in particular during spring flood. In forested catchments most TM concentrations increased at spring flood, but for Rb and Sc a decrease was observed. Conversely, in wetland influenced catchments the opposite seasonal variation was observed, i.e. concentrations of all TM decreased by a factor of 2 to 3. The seasonal variation of Fe shows a similar pattern to many TM, due to the association of TM to Fe oxyhydroxides. In particular, Fe correlates significantly with Cr and Pb in a forested headwater stream (r2=0.77 and r2=0.71, respectively, p<0.05). In the wetland headwater stream similar correlations between Fe and TM are found, but DOC also correlates significantly with As, Cd, Ni, and Pb (r2=0.92, p<0.05).A significant negative correlation (p<0.05) was observed between coverage of wetlands and average concentrations of Cr, Cu, Ge, Ni, Sc and Y. The results indicate that wetlands act as sinks for these elements. Alternatively, there is a source limitation in wetlands and that increased concentrations during base flow are due to mineral groundwater influence. Positive correlation with wetland coverage was only observed for Pb (r2=0.79, p<0.05), indicating that wetlands acts as a source for this element. Sulfate concentrations correlated negatively (r2=0.97, p<0.05) with increasing coverage of wetlands, which highlights the importance of sulfate reduction within wetland areas.This study emphasizes the importance of considering stream water chemistry from a landscape perspective.
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| 18. |
- Björkvald, Louise, et al.
(författare)
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Trace metals and sulphur isotopes in samll boreal streams: the influence of landscape type
- 2008
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Ingår i: 2008 Ocean Sciences Meeting. ; , s. 1-
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Konferensbidrag (refereegranskat)abstract
- The transport of trace metals (TM) and dissolved organic carbon (DOC) from headwater streams to the sea is influenced by various landscape elements. Our focus was to investigate the influence of major landscape elements on observed concentrations of dissolved metals (e.g. As, Cd, Co, Fe, Pb), DOC, sulphate, and sulphur isotope composition in streams, north- eastern Sweden, a coastal region characterized by peat wetlands and coniferous forests.Stream water samples collected from 10 streams (0.13 to 67 km2) in a boreal stream network reveal that landscape type (i.e. coverage of wetland and forest) is significant for river chemistry. Streams with different catchment characteristics responded differently to hydrological episodes. In forested streams, concentrations of TM, Fe and DOC increased, while they decreased in wetland influenced streams. Furthermore, Fe and Pb correlated positively with wetland coverage. Moreover, significantly lower average sulphate concentrations, but higher isotope values, were observed in wetland streams.This study emphasises the importance of understanding stream water chemistry from a landscape perspective in order to identify potential environments where climate change may induce enhanced metal mobilization in the future.
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| 19. |
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| 20. |
- Borg, Anders, 1978-
(författare)
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Theoretical Photochemistry : Halogenated Arenes, Phytochromobilin, Ru(II)polypyridyl complexes and 6-4 photoadducts
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents Quantum Chemical calculations on the Photochemistry of Halogenated benzenes, Phytochromobilin, Ruthenium Polypyridyl complexes and 6-4 photoadducts in DNA. The work is focused on improving the understanding of a number of experimentally observed photochemical processes in these systems. New results regarding the mechanism of photodissociation of halogenated arenes, photointerconversion of phytochromobilin are presented, as well as of the photoprocesses of Ruthenium Polypyridyl complexes and new mechanistic insights in the repair of 6-4 photoadducts in DNA.
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| 21. |
- Borg, Carola, 1973-, et al.
(författare)
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Subject- and experience-bound differences in teachers' conceptual understanding of sustainable development
- 2014
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Ingår i: Environmental Education Research. - : Routledge. - 1350-4622 .- 1469-5871. ; 20:4, s. 526-551
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Tidskriftsartikel (refereegranskat)abstract
- This article describe the results of a nationwide questionnaire study of 3229 Swedish upper secondary school teachers’ understanding of sustainable development in relation to their subject discipline and teaching experience. Previous research has shown that teachers have difficulties understanding the complex concept of sustainable development. According to the Swedish curriculum all teachers in all subjects should integrate a holistic perspective of sustainable development including economic, ecological and social dimensions. This study shows that teachers differ in their understanding of the concept mostly according to their subject traditions. Social science teachers emphasize social dimensions, and science teachers’ ecological dimensions, respectively. Teachers are aware of the relevance of the three dimensions to various degrees, but do not generally have a holistic understanding. The greatest uncertainty in teachers’ understanding is related to the economic dimension. Science and social science teachers are critical of incorporating economic growth into the concept of sustainable development while language, vocational and esthetical-practical teachers are not. No experience-bound differences of the teachers’ understanding could be found, but recently qualified teachers consider their understanding of sustainable development to be poorer in comparison to more experienced teachers’ self-evaluation. The study highlights the need for further training in sustainable development since more than 70 % of the questioned teachers stated that they need such training.
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| 22. |
- Borg, Carola, 1973-, et al.
(författare)
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The barriers encountered by teachers implementing education for sustainable development
- 2012
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Ingår i: Research in Science & Technological Education. - : Informa UK Limited. - 0263-5143 .- 1470-1138. ; 30:2, s. 185-207
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Tidskriftsartikel (refereegranskat)abstract
- Background : According to the Swedish curriculum teachers in all subjects have a responsibility to integrate a holistic perspective of sustainable development (SD) and teach according to an education for sustainable development (ESD) approach. However previous research has shown that teachers from different subjects perceive SD differently. Purpose : The study aimed at investigating if and how teachers’ subject area influences their ability to implement a holistic perspective of ESD; we investigated both the impact of teaching traditions and the barriers that teachers experienced. Sample : A stratified sample of 224 Swedish upper secondary schools participated. An online questionnaire was sent and answered by a total of 3229 teachers at these schools. In total, there were 669 science teachers, 373 social science teachers, 483 language teachers, 713 vocational and esthetical–practical teachers, and 739 teachers from other disciplines who participated in the survey. Design and methods : The questionnaire consisted of questions requiring Likert-scale responses and multiple-choice questions. The data from the questionnaire were analyzed using Pearson’s Chi-square test and one-way ANOVA. The significance level accepted was p < 0.05. Results : Teachers were influenced by their own subject traditions. Science teachers in our study were grounded in the fact-based tradition and lectures were the most common teaching method used. The teaching tradition of the social science teachers seemed to be most in line to an ESD approach. Many language teachers (41%) stated they did not include SD issues in their teaching at all. Among the barriers identified, the most common obstacles were that the teachers lacked inspiring examples of how to include SD in their teaching and that they lacked the necessary expertise about SD. Conclusion : This study highlights the need for the management within schools to create opportunities for teachers to work collaboratively when teaching ESD. It is also important to provide further training that is adjusted to the needs of different disciplines.
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| 23. |
- Borg, Carola, 1973-
(författare)
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Utbildning för hållbar utveckling ur ett lärarperspektiv : Ämnesbundna skillnader i gymnasieskolan
- 2011
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis investigates how teachers from different disciplines understand and implement education for sustainable development in their teaching. A nationwide questionnaire study was conducted with 3229 upper secondary school teachers representing 224 schools in Sweden. The concept of sustainable development is complex and research has shown that teachers exhibit uncertainties in their understanding of it, and that the way they conceptualize sustainable development can have consequences for how they incorporate it into their teaching. Previous research has emphasized that Education for Sustainable Development (ESD) should promote interdisciplinary and holistic learning rather than traditional subject-based learning. This is in accordance with the Swedish curriculum, which emphasizes that all teachers in all subjects should integrate education for sustainable development. The teachers in the study were grouped into four disciplines; science-, social science-, language-, and vocational/esthetical-practical teachers. The results showed that there were many subject-bound barriers to successful implementation of ESD. Teachers were influenced by their subject tradition in: 1) how they understand sustainable development, 2) which teaching methods they use, 3) which barriers they experience, and 4) which teaching tradition they work within. Because of these differences it is important to adjust any further training of teachers according to their discipline. This study highlights the need for improved teacher education and further training of in-service teachers; more than 70% of the teachers stated that they need such training. It also highlights the issue how strong subject-bound traditions make it difficult to implement general goals of the curricula such as sustainable development.
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| 24. |
- Borg, Hans, et al.
(författare)
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Comparative determinations of metals in fish : An interlaboratory trial
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Institute of Applied Environmental Research (ITM) in Sweden was assigned by theSwedish Environmental Protection Agency, Naturvårdsverket (NV), to organize a projectwith the purpose to compare results of analyses from different laboratories regarding metals infish liver and mercury in fish muscle. The analyses should be made on samples from perchfrom one of the national monitoring program lakes in southern Sweden, and the invitedlaboratories should primarily be laboratories that are potential performers in the program. TheContaminant Research Group at the Swedish Museum of Natural History was at the sametime assigned to organize a similar project, regarding organic pollutants in fish muscle.
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| 25. |
- Borg, Henrik, et al.
(författare)
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Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15-34 yrs) in the Diabetes Incidence Study in Sweden (DISS)
- 2003
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 46:2, s. 173-181
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis. We aimed to evaluate how an aetiology-based classification, as recommended in the ADA and WHO guidelines for classification of diabetes mellitus, matches clinical judgement in the Diabetes Incidence Study in Sweden (DISS), a study covering incident cases of diabetic patients aged 15 to 34 years. Methods. During a 1-year period (1998), blood samples were taken at diagnosis and 4 months (median) thereafter. Patients were classified according to clinical judgement by the reporting physicians and assessments of islet antibodies (ICA, GADA, and IA-2A) and plasma C-peptide. Results. In 1998, 422 patients were registered in DISS. Among the 313 patients participating in the follow-up, most with clinical Type 1 diabetes (185/218, 85%, 95% CI 79-89%) were islet antibody positive (ab+) at diagnosis. In addition, 14 out of 58 (24%, 14-37%) with clinical Type 2 diabetes and 21 out of 37 (57%, 40-73%) with unclassifiable diabetes were antibody positive at diagnosis. Further to this, 4 out of 33 (12%, 3-28%) were antibody negative with clinical Type 1 diabetes and 4 out of 44 (9%, 3-22%) with Type 2 had converted to antibody positive at follow-up. Among those who were constantly antibody negative, 10 out of 29 (34%, 18-54%) with clinical Type 1 and 1 out of 16 (6%, 0-30%) with unclassifiable diabetes had fasting plasma C-peptide concentrations below the normal range (<0.25 nmol/l) at follow-up. Conclusion/interpretation. Most young adults with clinical Type 1 diabetes (199/218, 91%) had objective Type 1 (ab+ at diagnosis/follow-up and/or low fasting plasma C-peptide concentrations at follow-up), as did one third (18/58, 31%) with clinical Type 2 diabetes and more than half (22/37, 59%) with unclassifiable diabetes. About 10% of those who were antibody negative converted to antibody positive. Our study underlines that a classification considering aetiology is superior to clinical judgement.
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| 26. |
- Borg, Hans, et al.
(författare)
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Long-term trends of water chemistry in mountain streams in Sweden - slow recovery from acidification
- 2014
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Ingår i: Biogeosciences. - Göttingen : COPERNICUS GESELLSCHAFT MBH. - 1726-4170 .- 1726-4189. ; 11:1, s. 173-184
-
Tidskriftsartikel (refereegranskat)abstract
- The water chemistry of streams and precipitation in the province of Jamtland, northern Sweden has been monitored since the 1980s to study long-term trends, occurrence of acid episodes, and effects of liming. The acidity in precipitation increased in the 1970s, followed by a loss of acid neutralizing capacity (ANC) and low pH in the streams. Sulfur deposition began to decrease in the 1980s, until approximately 2000, after which the decrease levelled out. Stream water sulfate concentration followed the precipitation trend but decreased more slowly and since the late 1990s a subtle increase was observed. Sulfate concentrations in the snow typically have been higher than or equal to the stream sulfate levels. However, during the period of rapid deposition decrease and also since 2005 stream sulfate has sometimes exceeded snow sulfate, indicating desorption of stored soil sulfate, possibly because of climate-related changes in runoff routes through the soil profiles, following shorter periods of frost. From 1982 to 2000, total organic carbon (TOC) increased by approximately 0.1 mg L-1 yr(-1). The mean trends in sulfate and TOC from approximately 1990 until today were generally opposite. Acidic episodes with pH 4.0 at flow peaks occurred frequently in the unlimed streams, despite relatively well-buffered waters at baseflow. To evaluate the main causes for the loss of ANC during episodes, the changes in major ion concentrations during high flow episodes were evaluated. The most important factors contributing to ANC loss were dilution of base cations (Na+, K+, Ca2+, Mg2+), enrichment of organic anions and enrichment of sulfate. Wetland liming started in 1985 after which the earlier observed extreme peak values of iron, manganese and aluminium, did not reoccur. The studied area is remote from emission sources in Europe, but the critical load of acidity is still exceeded. The long-term recovery observed in the unlimed streams is thus slow, and severe acidic episodes still occur.
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| 27. |
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| 28. |
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| 29. |
- Borg, Jörgen, et al.
(författare)
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Cerebral pares, CP
- 2006
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Ingår i: Neurologi (fjärde upplagan). - : Liber. ; , s. 337-343
-
Bokkapitel (populärvet., debatt m.m.)
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| 30. |
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| 31. |
- Borg, Kristian, et al.
(författare)
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Comparison of seven measures of sickness absence-based on data from three counties in Sweden
- 2006
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Ingår i: Work. - 1051-9815 .- 1875-9270. ; 26:4, s. 421-428
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Tidskriftsartikel (refereegranskat)abstract
- The objective was to compare the applicability of and results provided by the two measures of sickness absence used most often within the Swedish social insurance administration (that is, unadjusted sick-leave rate and adjusted sick-leave rate) and five measures suggested by epidemiological researchers. Data consisted of four cross-sectional data sets of registry sick-leave data covering four separate years (1997-2000) in three counties. In total 454,000 persons qualified for sickness insurance and aged 20-64 years were included. The two measures used within the social insurance administration and three of the five measures suggested by epidemiological researchers revealed sex-related dissimilarities in absence patterns that indicated that women had more sickness absence than men. However, in marked contrast to those results, two of the epidemiologically based measures (i.e., length of sickness absence and duration of sickness absence) instead showed highly comparable rates of sick leave for men and women, and such information is seldom obtained, albeit definitely of importance, when trying to make a correct assessment of sickness absence. The measure of sickness absence that is used influences the findings and should therefore be chosen with care. Complementing the measures used in the social insurance administration by five measures suggested by epidemiological researchers provided a more informative and comprehensive picture of sickness absence in a population. Further investigations into the effect of using different measures is needed, as well as international consensus on what to call different measures.
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| 32. |
- Borg, Lena, et al.
(författare)
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Framework for Structuring Procurement Contracts
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this paper is to propose a new structure for classifying contract types and paymentmethods. Concerning the procurement contract types the first important feature is the stepwisestructure with three main steps in the contract design: (1) should the contract only includeconstruction or both construction and operation/maintenance? (2) Who should do the detaileddesign of the premise? (3) How many contractors should the client use? An important newfeature of the structure is that in both step 2 and step 3 there is a continuum of alternatives.Concerning the payment methods the structure is primarily based on how the project specificrisks are shared.
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| 33. |
- Borg, Lena, et al.
(författare)
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Framework for Structuring Procurement Contracts
- 2014
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Ingår i: Australasian Journal of Construction Economics and Building. - : UTS ePRESS. - 1835-6354 .- 1837-9133. ; 14:4, s. 71-84
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this paper is to propose a new framework for structuring contract types and payment methods. Concerning procurement contracts, the first important new feature of this framework is a stepwise structure with three main steps in the contract design: (1) what will be procured—should the contract only include construction, or should it include both construction and operation/maintenance (2) who will do the detailed design of the premise and (3) how many contractors will the client use? The second important new feature of this framework is that both step 2 and step 3 include a continuum of alternatives. Concerning payment methods, the new framework is primarily based on how the specific risks of the project are shared. These frameworks can be useful for policy formulation in that they can help to avoid some problematic ways of formulating policies.
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| 34. |
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| 35. |
- Borg, Lena
(författare)
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Procurement Contracts, Innovation and Productivity in the Construction Sector : Five Studies
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With its size, large number of actors, and its impact on everyday life, the construction sector plays an important role in every nation’s economy and in the improvement of the built environment. The recognition of this fact by the sector, in combination with the reputation for being conservative, problematic, having low productivity growth, and low pressure for change leads to a focus on different strategies that can be used to improve of the sector. Suggestions to improve the productivity in sector have been many during the years. One example is enhanced procurement contracts that encourage long-term orientations to improve the performance outcome and increase innovations.This thesis consists of five studies with specific objectives. The overall objective is, however, to increase the understanding of how to enhance the conditions to improve the construction sector. This is a response to the concerns that the actors on the market have difficulties carrying out necessary measures to make improvements in the construction sector. Procurement contracts were studied in two ways; bundled procurement contracts with service as a key to create incentives for innovations (Paper II) and the difficulty in evaluating the effects of different procurement contracts because of unclear concepts (Paper I). Innovations were also studied in two ways: the importance for creating incentives for “good” innovations and how to open up for more transparency with respect to innovation (Paper III), and the direct and indirect effects a specific innovation have in the design choices of construction in profit-maximising firms (Paper IV). Policies are based on data and misleading data can lead to mistaken recommendations. Indications of measurement errors in the calculations of productivity have been reported which leads to an interest to increase the reliability of productivity calculations (Paper V).The first paper has the focus to make the evaluation process easier, for the scholar, the actors on the market as well as for governmental institutions which formulate policies, by trying to make the relation between different contract types clearer with a new framework for structuring procurement contracts. The second papers are showing that bundling construction with service will not automatically increase profit for firms in the sector, rather that it might be an alternative way to transfer the risk in construction projects. Moral Hazard problems can also reduce the potential positive effects.Paper III wants to shift the focus from the quantity of innovations to how incentives can nourish “good” innovation and suggests a new classification system for technical innovations. The objective is to achieve increased transparency and reduced information asymmetry in the construction sector. Paper IV takes it starting point in an indicated shift in developers’ planning and construction practices for laundry facilities in owner-occupied multi-family buildings. The mapping of the shift shows that a change in regulations can have an effect on how we build, and that developers are using spaces in innovative ways, which in turn can have unforeseen external effects. The finding indicates that even though the number of appliances has increased since the 1990s, the energy consumption has not necessarily increased during the usage phase, depending on the energy performance of the appliances and on user behaviour.Paper V highlights the effects of including more rigorously and detailed gathered indicators of characteristics in the calculations of productivity development figures in the sector. By including more cost-driving characteristics, it should be easier to distinguish pure price changes from price changes related to increase in quality. It is, important to bear in mind that there are several projects yearly that are delivered on time, within budget, with good quality and where innovations have been used. Seen against the background of this thesis, it can indeed be stated that improvements are needed if we intend to create an innovative friendly work environment that will contribute to productivity growth. However, the contribution here is also a warning that the evaluation tools that are used to describe the sector might not measure what we intend to measure.
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| 36. |
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| 37. |
- Borg, Tor, et al.
(författare)
-
Mått på bostadsbristen : Förslag på hur återkommande bedömningar ska utföras
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Boverket fick i juni 2019 i uppdrag av regeringen att lämna förslag på hur återkommande bedömningar av bostadsbristen ska utföras samt att lämna förslag på enhetliga begrepp som ska användas vid kommunikation kring bostadsbristen. Avsikten är att de presenterade beräkningarna ska kunna användas i arbetet med bostadsförsörjningsfrågor och underlätta arbetet med att planera, utföra och följa upp insatser för att åtgärda bostadsbristen. Boverket har tagit fram en årlig beräkningsmodell där antalet hushåll som saknar en rimlig bostad beräknas på både nationell, regional och lokal nivå. Vad som är en rimlig bostad definieras enligt en uppsättning kriterier och normer. Kvantitativa mått visar hur många hushåll som har en boendesituation som inte uppfyller de olika kriterierna. Samråd har skett med Sveriges Kommuner och Regioner (SKR) samt med Socialstyrelsen under uppdragets gång. Båda anser att de givits utrymme att framföra sin mening och har förklarat sig nöjda med samrådet. Avstämningar har också gjorts med en rad andra aktörer. Denna rapport utgör Boverkets slutredovisning av uppdraget. Rapporten har tagits fram av en projektgrupp bestående av Tor Borg, Bengt J Eriksson, Oskar Gramstad, Ulla-Christel Götherström, Hans Jonsson, Bo Söderberg och Hang Zettervall, med den förstnämnda som projektledare.
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| 38. |
- Borg, Tomas
(författare)
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Pelvic Ring Injuries and Acetabular Fractures : Quality of Life Following Surgical Treatment
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim was to study outcome following surgery of the injured pelvis with focus on assessment from the patient’s perspective. All adult patients operatively treated for pelvic ring injuries or acetabular fractures at the Department of Orthopaedics, Uppsala University, starting 2003 were prospectively included and followed with quality of life (QoL) instruments for 2 years. The most common trauma mechanism was motor vehicle accident (MVA). Study I included 54 patients with pelvic ring injuries during the three-year period 2003-2005. The two instruments, SF-36 and LiSat-11, were used. In 45 responders lower than normative QoL and life satisfaction prevailed at two years after the injury. Study II included 12 patients with pelvic ring injuries or acetabular fractures sustained following a jump from height in an attempt to commit suicide. At four years all patients were still alive and SCID-interviews performed by a psychiatrist revealed low recurrence of self-destructive behaviour and high QoL in the younger patients. Study III included 136 patients with acetabular fractures where 52 had elementary and 84 associated fracture patterns. Fracture reduction was 0-1 mm in 106 patients and 2 mm or more in 30. QoL was significantly higher in patients with anatomically reduced fractures. Physical SF-36 domains improved with time, albeit QoL was lower than norm. Study IV had the aim to construct a condition-specific outcome instrument for patients with acetabular fractures. Closed and open questions were sent to 127 consecutive acetabular fracture patients at 6, 12 and 24 months following surgery. Responses were validated through factor analysis, scree tests, item reduction and principal component analysis which resulted in a multi-item verbal descriptive scale (VDS) with six condition-specific questions related to “Pain”, “Walking”, “Hip motion”, “Leg numbness”, “Sexual life”, “Operation scar” and a global question concerning impact on daily life activities for acetabular fracture assessment.
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| 39. |
- Breitholtz, Magnus, et al.
(författare)
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An evaluation of free water surface wetlands as tertiary sewage water treatment of micro-pollutants
- 2012
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Ingår i: Ecotoxicology and Environmental Safety. - : Elsevier BV. - 0147-6513 .- 1090-2414. ; 78, s. 63-71
-
Tidskriftsartikel (refereegranskat)abstract
- Increased attention is currently directed towards potential negative effects of pharmaceuticals and other micro-pollutants discharged into the aquatic environment via municipal sewage water. A number of additional treatment technologies, such as ozonation, have therefore been suggested as promising tools for improving the removal efficiency of pharmaceuticals in existing Sewage Treatment Plants (STPs). Constructed wetlands are also capable of removing a variety of micro-pollutants, including some pharmaceuticals, and could hence be a resource efficient complement to more advanced treatment technologies. The purpose of the present study was therefore to increase the knowledge base concerning the potential use of constructed wetlands as a treatment step to reduce emissions of organic micro-pollutants from municipal sewage effluents. Under cold winter conditions, incoming and outgoing waters from four Swedish free water surface wetlands, operated as final treatment steps of sewage effluent from municipal STPs, were sampled and analyzed for levels of a set of 92 pharmaceuticals and 22 inorganic components as well as assessed using subchronic ecotoxicity tests with a macro-alga and a crustacean. Sixty-five pharmaceuticals were detected in the range from 1 ng L-1 to 7.6 mu g L-1 in incoming and outgoing waters from the four investigated wetlands. Although the sampling design used in the present study lacks the robustness of volume proportional to 24 h composite samples, the average estimated removal rates ranged from 42% to 52%, which correlates to previous published values. The effects observed in the ecotoxicity tests with the macro-alga (EC(50)s in the range of 7.5-46%) and the crustacean (LOECs in the range of 11.25-90%) could not be assigned to either pharmaceutical residues or metals, but in general showed that these treatment facilities release water with a relatively low toxic potential, comparable to water that has been treated with advanced tertiary treatments. From the present study it can be concluded that constructed wetlands may provide a complementary sewage treatment option, especially where other treatment is lacking today. To fully remove micro-pollutants from sewage effluent, however, other more advanced treatment technologies are likely needed.
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| 40. |
- Bång, Joakim
(författare)
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Purification, Stereoisomeric Analysis and Quantification of Biologically Active Compounds in Extracts from Pine Sawflies, African Butterflies and Orchid Bees
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Stereochemistry plays an important role in nature because biologically important molecules such as amino acids, nucleotides and sugars, only exist in enantiomerically pure forms. Semiochemicals carry messages, between the same species (pheromones) and between different species (allelochemicals). Both pheromones and allelochemicals can be used as environmentally friendly pest management. Many semiochemicals, i.e. behaviour modifying chemicals, consist of pure or well-defined mixtures of stereoisomers, where some of the other stereoisomers can be repellent. It is therefore important to be able to separate them to produce a synthetic pheromone in a mixture that is attractive.Pine sawflies are a family of insects that in some cases can be severe defoliators of conifer trees. Diprion pini, Diprion similis and Neodiprion sertifer are severe pests for these trees and have got the most attention in pine sawfly pheromone studies. The pheromone precursors are stored in the female body as long-chain secondary alcohols, which, when released, are esterified to acetates or propionates. The alcohols are chiral, and normally one of the stereoisomer is the main pheromone component, sometimes possible together with other stereoisomers as essential minor components.Bicyclus is a genus of African butterflies, and especially Bicyclus anynana has become a popular model for the study of life history evolution, morphology, mating choice and genetics. The wing pattern of Bicyclus differs depending on the season, with large eyespots during the rain-season and small or absent spots during the dry season. Euglossa is one of the genera among the orchid bees in the Neotropics that does not produce its own pheromone. Instead, the males collect fragrances from orchids and other sources and store them in a pocket in their hind legs. Both Bicyclus and Euglossa use semiochemicals similar to pine sawflies, and thus can be analysed by the same methods.Pheromones and other semiochemicals in insects are often present in low amounts in a complex matrix, and purification of the sample before chemical analysis is often required. A common method is gradient elution on a solid phase silica column. Separation of stereoisomers can be achieved either by using a column with a chiral stationary phase (CSP) or with pre-column derivatisation using a column with an achiral stationary phase (ASP) or a combination of both, with mass detection as the dominant detection method. The purpose of this work has been to improve the purification method, find suitable methods to separate the stereoisomers of secondary alcohols, and to apply this on extracts of insects.By selecting the right fractions to collect during gradient elution the purification method was optimised. To reduce plasticizer contamination from ordinary columns, solid phase columns of Teflon or glass were used. For pre-column derivatisation of different chiral alcohols various acid chlorides were tested. For the pine sawfly pheromone precursors enantiopure (2S)-2-acetoxypropionyl chloride was the best choice. To separate some of the stereoisomers achiral 2-naphthoyl chloride was used. For derivatisation of 6,10,14-trimethylpentadecan-2-ol (R)-trans-chrysanthemoyl chloride was the best choice. The derivatised alcohols were separated on different columns, both chiral and non-chiral. Varian FactorFour VF-23ms was chosen as a general-purpose column, the Agilent HP-88 column was the best column with an ASP of those tested, and the Chiraldex B-PA column (CSP) was the only one that could separate all eight stereoisomers of derivatised 3,7-dimethylundecan-2-ol, 3,7-dimethyldodecan-2-ol, and 3,7-dimethyltridecan-2-ol.To determine the stereoisomeric purity of standard solutions used in field experiments and extracts of different species of insects the optimised methods were applied. For extracts from B. anynana, Euglossa and Neodiprion lecontei this work describe the first determination of the stereochemistry of some of their semiochemicals.For the determination of the stereochemistry of chiral semiochemicals the methods for purification and separation presented herein have shown to be of great value. The results will hopefully contribute to a better understanding of the communication among insects, and ultimately to a more environmentally friendly pest control.
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| 41. |
- Carroll, L. J., et al.
(författare)
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Prognosis for mild traumatic brain injury : Results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury
- 2004
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Ingår i: Journal of Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1650-1977 .- 1651-2081. ; 43, s. 61-
-
Forskningsöversikt (refereegranskat)abstract
- We searched the literature on the epidemiology, diagnosis, prognosis, treatment and costs of mild traumatic brain injury. Of 428 studies related to prognosis after mild traumatic brain injury, 120 (28%) were accepted after critical review. These comprise our best-evidence synthesis on prognosis after mild traumatic brain injury. There was consistent and methodologically sound evidence that children's prognosis after mild traumatic brain injury is good, with quick resolution of symptoms and little evidence of residual cognitive, behavioural or academic deficits. For adults, cognitive deficits and symptoms are common in the acute stage, and the majority of studies report recovery for most within 3-12 months. Where symptoms persist, compensation/litigation is a factor, but there is little consistent evidence for other predictors. The literature on this area is of varying quality and causal inferences are often mistakenly drawn from cross-sectional studies.
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| 42. |
- Catucci, Irene, et al.
(författare)
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Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility
- 2018
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Ingår i: Genetics in Medicine. - : Elsevier BV. - 1098-3600. ; 20:4, s. 452-457
-
Tidskriftsartikel (refereegranskat)abstract
- PurposeMonoallelic germ-line mutations in the BRCA1/FANCS, BRCA2/FANCD1 and PALB2/FANCN genes confer high risk of breast cancer. Biallelic mutations in these genes cause Fanconi anemia (FA), characterized by malformations, bone marrow failure, chromosome fragility, and cancer predisposition (BRCA2/FANCD1 and PALB2/FANCN), or an FA-like disease presenting a phenotype similar to FA but without bone marrow failure (BRCA1/FANCS). FANCM monoallelic mutations have been reported as moderate risk factors for breast cancer, but there are no reports of any clinical phenotype observed in carriers of biallelic mutations.MethodsBreast cancer probands were subjected to mutation analysis by sequencing gene panels or testing DNA damage response genes.ResultsFive cases homozygous for FANCM loss-of-function mutations were identified. They show a heterogeneous phenotype including cancer predisposition, toxicity to chemotherapy, early menopause, and possibly chromosome fragility. Phenotype severity might correlate with mutation position in the gene.ConclusionOur data indicate that biallelic FANCM mutations do not cause classical FA, providing proof that FANCM is not a canonical FA gene. Moreover, our observations support previous findings suggesting that FANCM is a breast cancer-predisposing gene. Mutation testing of FANCM might be considered for individuals with the above-described clinical features.Genetics in Medicine advance online publication, 24 August 2017; doi:10.1038/gim.2017.123.
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| 43. |
- Christensen, Sarah Friis, et al.
(författare)
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Healthcare resource utilization in patients with myeloproliferative neoplasms: A Danish nationwide matched cohort study
- 2022
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Ingår i: European Journal of Haematology. - : John Wiley & Sons. - 0902-4441 .- 1600-0609.
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Tidskriftsartikel (refereegranskat)abstract
- Few studies have assessed healthcare resource utilization (HRU) in patients with Philadelphia-negative myeloproliferative neoplasms (MPN) using a matched cohort design. Further, no detailed assessment of HRU in the years preceding an MPN diagnosis exists. We conducted a registry-based nationwide Danish cohort study, including patients with essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN diagnosed between January 2010 and December 2016. HRU data were summarized annually from 2 years before MPN diagnosis until emigration, death, or end of study (December 2017). We included 3342 MPN patients and 32 737 comparisons without an MPN diagnosis, matched on sex, age, region of residence, and level of education. During the study period, the difference in HRU (rate ratio) between patients and matched comparisons ranged from 1.0 to 1.5 for general practitioner contacts, 0.9 to 2.2 for hospitalizations, 0.9 to 3.8 for inpatient days, 1.0 to 4.0 for outpatient visits, 1.3 to 2.1 for emergency department visits, and 1.0 to 4.1 for treatments/examinations. In conclusion, MPN patients had overall higher HRU than the matched comparisons throughout the follow-up period (maximum 8 years). Further, MPN patients had substantially increased HRU in both the primary and secondary healthcare sector in the 2 years preceding the diagnosis.
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| 44. |
- Christensen, Sarah Friis, et al.
(författare)
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Labor Market Attachment in Patients with Myeloproliferative Neoplasms: A Nationwide Matched Cohort Study
- 2021
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 138:Suppl 1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Myeloproliferative neoplasms (MPNs) are characterized by a substantial symptom burden, risk of debilitating complications (e.g., thrombosis), and increased comorbidity. Recently, three comprehensive questionnaire studies (Mesa 2016, Harrison 2017, Jingbo 2018) have reported a high impact of MPNs on patients' ability to work. However, no registry-based studies have assessed labor market attachment (LMA) of MPN patients and matched nonMPN comparisons.AIM: To assess the pre- and post-diagnostic LMA of MPN patients and matched nonMPN comparisons.METHODS: We conducted a descriptive, registry-based nationwide cohort study, using data from the Danish National Chronic Myeloid Neoplasia Registry including all Danish MPN patients diagnosed between January 2010 and December 2016. Population-based cohorts of nonMPN comparisons were constructed by 1:10 matching on age, sex, level of education, and region of residence. Data on LMA were retrieved from the Danish Register for Evaluation of Marginalization, which holds information on all public transfer payments in Denmark. Data were linked using the unique civil registration number, which identifies all Danish citizens. The LMA endpoints were defined for each individual as working (not receiving any type of transfer payment), unemployed, receiving transfer payment for either sick leave, disability pension, age pension, or other health-related benefits (e.g., wage-subsidized employment). We assessed LMA weekly for each individual from two years before diagnosis until death, emigration, or two years after the diagnosis. For each cohort, we presented LMA as proportions with 95% confidence intervals (CIs), as well as the proportion of individuals who died during follow-up.RESULTS: The study included 3,342 MPN patients (1,140 essential thrombocythemia [ET]; 1,109 polycythemia vera [PV]; 533 myelofibrosis [MF]; and 560 unspecified MPN [MPN-U]) and 32,737 nonMPN comparisons (11,181 nonET; 10,873 nonPV; 5,217 nonPMF; and 5,466 nonMPN-U). The median age at time of diagnosis was: ET 67 years (interquartile range [IQR], 55-76); PV, 69 years (IQR, 61-77); PMF, 73 years (IQR, 66-79); and MPN-U, 72 years (IQR, 63-80).At time of MPN diagnosis, the majority of MPN patients and nonMPN comparisons received age pension (range: ET, 52.1% [95% CI, 49.2-55.0] to nonMF, 70.3% [95% CI, 69.1-71.6]). The proportions working were: ET, 35.1% (95% CI, 32.3-37.9) vs. nonET, 37.3% (95% CI, 36.5-38.2); PV, 22.6% (95% CI, 20.2-25.1) vs. nonPV, 30.8% (95% CI, 29.9-31.7); MF, 23.8% (95% CI, 20.2-27.4) vs. nonMF, 23.6% (95% CI, 22.5-24.8); and MPN-U, 22.1% (95% CI,18.7- 25.6) vs. nonMPN-U, 27.8% (95% CI, 26.6-29.0). Across MPN subtypes, a larger proportion of patients than comparisons were on sick leave: ET, 3.5% (95% CI, 2.4-4.6) vs. nonET, 1.3% (95% CI, 1.1-1.5); PV, 5.5% (95% CI, 4.2-6.8) vs. nonPV, 0.9% (95% CI, 0.7-1.1); MF (not applicable due to small numbers) vs. nonMF, 0.6% (95% CI, 0.4-0.8); and MPN-U, 3.0% (95% CI, 1.6- 4.5) vs. nonMPN-U, 1.0% (95% CI, 0.7-1.3). Regarding disability pension, the proportions ranged from 4.1% (95% CI, 2.4-5.8) to 5.0% (95% CI, 3.7-6.3) among patients and from 3.1% (95% CI, 2.6-3.6) to 4.7% (95% CI, 4.3-5.1) among comparisons. For both MPN patients and nonMPN comparisons, few were unemployed (≤3.3%) or received other health-related benefits (≤1.6%).Two years preceding diagnosis, the proportion of PV and MPN-U patients working was slightly lower than the matched comparisons: PV, 31.0% (95% CI, 28.4-33.8) vs. nonPV, 34.3% (95% CI, 33.5-35.2) and MPN-U, 28.2% (95% CI, 24.6-32.1) vs. nonMPN-U, 32.0% (95% CI, 30.7-33.2), while this difference was not observed between ET and MF patients and their respective comparisons.From two years before to two years after diagnosis, we observed slightly larger reductions in the proportion working among MPN patients than among comparisons. Among MPN patients, the proportion on sick leave including other health-related benefits, increased during the study period, while it remained unchanged among comparisons. The proportion of patients and comparisons on disability pension remained stable.CONCLUSION: Overall, our findings showed that Danish patients with ET, PV, MF, and MPN-U had slightly impaired LMA already two years before diagnosis and up to two years after diagnosis. Thus, fewer patients were working and more patients transferred to sick leave compared with matched individuals without MPN.
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| 45. |
- Couch, Fergus J., et al.
(författare)
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AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: A consortium of investigators of modifiers of BRCA1/2 study
- 2007
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Ingår i: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755. ; 16:7, s. 1416-1421
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Tidskriftsartikel (refereegranskat)abstract
- The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2. Consortium of Investigators of Modifiers of BRCA1/2 was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4,935 BRCA1 and 2,241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations was genotyped for F31I. Overall, homozygosity for the 311 allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined [hazard ratio (HR), 0.91; 95% confidence interval (95% CI), 0.77-1.061. Similarly, no significant association was seen in BRCA1 (HR, 0.90; 95% Cl, 0.75-1.08) or BRCA2 carriers (HR, 0.93; 95% CI, 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.
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| 46. |
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| 47. |
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| 48. |
- Ecke, Frauke, et al.
(författare)
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Sublethal Lead Exposure Alters Movement Behavior in Free-Ranging Golden Eagles
- 2017
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 51:10, s. 5729-5736
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Tidskriftsartikel (refereegranskat)abstract
- Lead poisoning of animals due to ingestion of fragments from lead-based ammunition in carcasses and offal of shot wildlife is acknowledged globally and raises great concerns about potential behavioral effects leading to increased mortality risks. Lead levels in blood were correlated with progress of the moose hunting season. Based on analyses of tracking data, we found that even sublethal lead concentrations in blood (25 ppb, wet weight), can likely negatively affect movement behavior (flight height and movement rate) of free ranging scavenging Golden Eagles (Aquila chrysaetos). Lead levels in liver of recovered post-mortem analyzed eagles suggested that sublethal exposure increases the risk of mortality in eagles. Such adverse effects on animals are probably common worldwide and across species, where game hunting with lead-based ammunition is widespread. Our study highlights lead exposure as a considerably more serious threat to wildlife conservation than previously realized and suggests implementation of bans of lead ammunition for hunting.
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| 49. |
- Edberg, Frida, 1966-
(författare)
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Bacteria and geochemistry in a former uranium open pit mine - mobilization of trace metals
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In mining areas around the world, chemical and biotic processes have lead to the release of toxic substances, e.g. metals. Microbial processes influence metal speciation, while the chemical environment shapes and controls microbial populations. This thesis has two parts and the papers cover various aspects of metal-to-microbe links in a former uranium mine at Ranstad, Sweden. The first part of the thesis examines bacteria-induced metal mobilization by the cultivation of Pseudomonas fluorescens with ore and minerals from the Ranstad mine. The presence of a mineral source stimulated bacterial growth. Pyoverdine-type siderophores typical for P. fluorescens were produced, but also other types of siderophores. The bacterial mobilization of metals is implied by the agreement in concentrations of Fe-pyoverdine complex and soluble Fe, and by the concentrations of Ni and Co in solution. U was mobilized from the ore as a result of bacterial growth raising pH. The second part of the thesis focus on the partitioning of metals and their links to the microbial communities in the water of the former open pit mine, Lake Tranebärssjön. The lake was pH-neutral to alkaline, highly stratified, and had an anoxic hypolimnion with high concentrations of metals and SO42-. Size fractionation showed the dissolved fraction dominating for most metals, while the particulate and colloidal fractions dominated for Fe. Chemical equilibrium models agreed reasonably well with these results. In the pyrosequencing study of the bacterial community, depth-related changes in water chemistry corresponded to a distinct shift in the microbial community, indicating a chemical control. The presence of metal- and SO42--reducing bacteria suggests a possible microbe – chemistry connection. The findings of this thesis could be used for the restoration and remediation of mining sites, and provides information on factors governing the establishment and control of bacterial populations in freshwaters.
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| 50. |
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