| 1. |
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| 2. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 3. |
- Andersson, Niklas, et al.
(författare)
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Model-Based Comparison of Batch and Continuous Preparative Chromatography in the Separation of Rare Earth Elements
- 2014
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Ingår i: Industrial & Engineering Chemistry Research. - : American Chemical Society (ACS). - 0888-5885 .- 1520-5045. ; 53:42, s. 16485-16493
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Tidskriftsartikel (refereegranskat)abstract
- The demand for rare earth elements (REEs) is growing, while the future supply is uncertain. Their unique electronic characteristics make them irreplaceable, and the commercial value of pure fractions is high. A model-based simulation study is presented that compares batch chromatography with the twin-column MCSGP (multicolumn countercurrent solvent gradient purification) process for ion-exchange chromatography of the four-component system neodymium, samarium, europium, and gadolinium. The last three components are considered products with individual purity requirements of 99%. The twin-column process has been shown to be a good alternative to the batch process regarding modifier consumption and productivity since it enables internal recycling to achieve high purities. A new cut strategy for MCSGP is applied where subfractions are taken from each outlet. Two multiobjective optimizations with yield, solvent productivity, and productivity objectives show that the MCSGP process is a better alternative than batch chromatography.
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| 4. |
- Borg, Andreas, 1976-, et al.
(författare)
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A Method for Improving the Treatment of Capacity Requirements in Large Telecommunication Systems
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Non-functional requirements crosscut functional models and are more difficult to enforce in system models. This paper describes a long-term research collaboration regarding capacity requirements between Linköping University and Ericsson AB. We describe an industrial case study on non-functional requirements as a background. Succeeding efforts dedicated to capacity include a detailed description of the term, a best practice inventory within Ericsson, and a pragmatic approach for how to annotate UML models with capacity information. The results are also represented as a method plug-in to the OpenUP software process and an anatomy facilitating the possibility to assess and improve an organization’s abilities to develop for capacity. The results combine into a method for how to improve the treatment of capacity requirements in large-scale software systems. Both product and process views are included, with emphasis on the latter.
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| 5. |
- Borg, Andreas, 1976-, et al.
(författare)
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Extending the OpenUP/Basic Requirements Discipline to Specify Capacity Requirements
- 2007
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Ingår i: Requirements Engineering Conference, 2007. RE '07. - : IEEE Computer Society. - 9780769529356 ; , s. 328-333
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Konferensbidrag (refereegranskat)abstract
- Software processes, such as RUP and agile methods, focus their requirements engineering part on use cases and thus functional requirements. Complex products, such as radio network control software, need special handling of non-functional requirements as well. We describe how we used the eclipse process framework to augment the open and minimal OpenUP/basic process with improvements found in management of capacity requirements in a case-study at Ericsson. The result is compared with another project improving RUP to handle performance requirements. The major differences between the improvements are that 1) they suggest a special, dedicated performance manager role and we suggest that present roles are augmented, 2) they suggest a bottom-up approach to performance verification while we focus on system performance first, i.e. top-down. Further, we suggest augmenting UMLl-2 models with capacity attributes to improve information flow from requirements to implementation.
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| 6. |
- Borg, Andreas, 1976-, et al.
(författare)
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Good Practice and Improvement Model of Handling Capacity Requirements of Large Telecommunication Systems
- 2006
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Ingår i: 14th IEEE International Requirements Engineering Conference (RE'06), Minneapolis/S:t Paul. - Los Alamitos, CA : IEEE Computer Society. - 0769525555 - 9780769525556 ; , s. 245-250
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Konferensbidrag (refereegranskat)abstract
- There is evidence to suggest that the software industry has not yet matured as regards management of nonfunctional requirements (NFRs). Consequently the cost of achieving required quality is unnecessarily high. To try and avoid this, the telecommunication systems provider Ericsson defined a research task to try and improve the management of requirements for capacity, which is one of the most critical NFRs. Linkoping University joined in the effort and conducted an interview series to investigate good practice within different parts of the company. Inspired by the interviews and an ongoing process improvement project a model for improvement was created and activities were synthesized. This paper contributes the results from the interview series, and details the subprocesses of specification that should be improved. Such improvements are about understanding the relationship between numerical entities at all system levels, augmenting UML specifications to make NFRs visible, working with time budgets, and testing the sub system level components on the same level as they are specified.
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| 7. |
- Borg, Andreas, 1976-, et al.
(författare)
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Integrating an Improvement Model of Handling Capacity Requirements with OpenUP/Basic Process
- 2007
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Ingår i: 13th International working conference on Requirements Engineering: Foundations for Software Quality (REFSQ'07), Trondheim, Norway. - Berlin Heidelberg : Springer. - 9783540730309 ; , s. 341-354
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Konferensbidrag (refereegranskat)abstract
- Contemporary software processes and modeling languages have a strong focus on Functional Requirements (FRs), whereas information of Non-Functional Requirements (NFRs) are managed with text-based documentation and individual skills of the personnel. In order to get a better understanding of how capacity requirements are handled, we carried out an interview series with various branches of Ericsson. The analysis of this material revealed 18 Capacity Sub-Processes (CSPs) that need to be attended to create a capacity-oriented development. In this paper we describe all these sub-processes and their mapping into an extension of the OpenUP/Basic software process. Such an extension will support a process engineer in realizing the sub-processes, and has at the same time shown that there are no internal inconsistencies of the CSPs. The extension provides a context for continued research in using UML to support negotiation between requirements and existing design.
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| 8. |
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| 9. |
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| 10. |
- Borg, Andreas, 1976-
(författare)
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Processes and Models for Capacity Requirements in Telecommunication Systems
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Capacity is an essential quality factor in telecommunication systems. The ability to develop systems with the lowest cost per subscriber and transaction, that also meet the highest availability requirements and at the same time allow for scalability, is a true challenge for a telecommunication systems provider. This thesis describes a research collaboration between Linköping University and Ericsson AB aimed at improving the management, representation, and implementation of capacity requirements in large-scale software engineering.An industrial case study on non-functional requirements in general was conducted to provide the explorative research background, and a richer understanding of identified difficulties was gained by dedicating subsequent investigations to capacity. A best practice inventory within Ericsson regarding the management of capacity requirements and their refinement into design and implementation was carried out. It revealed that capacity requirements crosscut most of the development process and the system lifecycle, thus widening the research context considerably. The interview series resulted in the specification of 19 capacity sub-processes; these were represented as a method plug-in to the OpenUP software development process in order to construct a coherent package of knowledge as well as to communicate the results. They also provide the basis of an empirically grounded anatomy which has been validated in a focus group. The anatomy enables the assessment and stepwise improvement of an organization’s ability to develop for capacity, thus keeping the initial cost low. Moreover, the notion of capacity is discussed and a pragmatic approach for how to support model-based, function-oriented development with capacity information by its annotation in UML models is presented. The results combine into a method for how to improve the treatment of capacity requirements in large-scale software systems.
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| 11. |
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| 12. |
- Borg, Andreas, 1976-, et al.
(författare)
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The Bad Conscience of Requirements Engineering : An Investigation in Real-World Treatment of Non-Functional Requirements
- 2003
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Ingår i: Third Conference on Software Engineering Research and Practice in Sweden (SERPS'03), Lund. ; , s. 1-8
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Konferensbidrag (refereegranskat)abstract
- Even though non-functional requirements (NFRs) are critical in order to provide software of good quality, the literature of NFRs is relatively sparse. We describe how NFRs are treated in two development organizations, an Ericsson application center and the IT department of the Swedish Meteorological and Hydrological Institute. We have interviewed professionals about problems they face and their ideas on how to improve the situation. Both organizations are aware of NFRs and related problems but their main focus is on functional requirements,primarily because existing methods focus on these. The most tangible problems experienced are that many NFRs remain undiscovered and that NFRs are stated in non-measurable terms. It became clear that the size andstructure of the organization require proper distribution of employees’ interest, authority and competence of NFRs. We argue that a feasible solution might be to strengthen the position of architectural requirements, which are more likely to emphasize NFRs.
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| 13. |
- Borg Hammer, Anne Sofie, et al.
(författare)
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Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia : An I-BFM Study Group collaboration
- 2023
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 7:6, s. 1045-1055
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Tidskriftsartikel (refereegranskat)abstract
- Hypodiploidy, defined as modal numbers (MNs) 45 or lower, has not been independently investigated in pediatric acute myeloid leukemia (AML) but is a well-described high-risk factor in pediatric acute lymphoblastic leukemia. We aimed to characterize and study the prognostic impact of hypodiploidy in pediatric AML. In this retrospective cohort study, we included children below 18 years of age with de novo AML and a hypodiploid karyotype diagnosed from 2000 to 2015 in 14 childhood AML groups from the International Berlin-Frankfurt-Münster (I-BFM) framework. Exclusion criteria comprised constitutional hypodiploidy, monosomy 7, composite karyotype, and t(8;21) with concurring sex chromosome loss. Hypodiploidy occurred in 81 patients (1.3%) with MNs, 45 (n = 66); 44 (n = 10) and 43 (n = 5). The most frequently lost chromosomes were chromosome 9 and sex chromosomes. Five-year event-free survival (EFS) and overall survival (OS) were 34% and 52%, respectively, for the hypodiploid cohort. Children with MN≤44 (n = 15) had inferior EFS (21%) and OS (33%) compared with children with MN = 45 (n = 66; EFS, 37%; OS, 56%). Adjusted hazard ratios (HRs) were 4.9 (P = .001) and 6.1 (P = .003). Monosomal karyotype or monosomy 9 had particular poor OS (43% and 15%, respectively). Allogeneic stem cell transplantation (SCT) in first complete remission (CR1) (n = 18) did not mitigate the unfavorable outcome of hypodiploidy (adjusted HR for OS was 1.5; P = .42). We identified pediatric hypodiploid AML as a rare subgroup with an inferior prognosis even in the patients treated with SCT in CR1.
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| 14. |
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| 15. |
- Borg, Kristian, et al.
(författare)
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Comparison of seven measures of sickness absence-based on data from three counties in Sweden
- 2006
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Ingår i: Work. - 1051-9815 .- 1875-9270. ; 26:4, s. 421-428
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Tidskriftsartikel (refereegranskat)abstract
- The objective was to compare the applicability of and results provided by the two measures of sickness absence used most often within the Swedish social insurance administration (that is, unadjusted sick-leave rate and adjusted sick-leave rate) and five measures suggested by epidemiological researchers. Data consisted of four cross-sectional data sets of registry sick-leave data covering four separate years (1997-2000) in three counties. In total 454,000 persons qualified for sickness insurance and aged 20-64 years were included. The two measures used within the social insurance administration and three of the five measures suggested by epidemiological researchers revealed sex-related dissimilarities in absence patterns that indicated that women had more sickness absence than men. However, in marked contrast to those results, two of the epidemiologically based measures (i.e., length of sickness absence and duration of sickness absence) instead showed highly comparable rates of sick leave for men and women, and such information is seldom obtained, albeit definitely of importance, when trying to make a correct assessment of sickness absence. The measure of sickness absence that is used influences the findings and should therefore be chosen with care. Complementing the measures used in the social insurance administration by five measures suggested by epidemiological researchers provided a more informative and comprehensive picture of sickness absence in a population. Further investigations into the effect of using different measures is needed, as well as international consensus on what to call different measures.
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| 16. |
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| 17. |
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| 18. |
- Borg, Kristian, et al.
(författare)
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Intragenic deletion of TRIM32 in compound heterozygotes with sarcotubular myopathy/LGMD2H
- 2009
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Ingår i: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 30:9, s. E831-E844
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Tidskriftsartikel (refereegranskat)abstract
- In 2005 the commonality of sarcotubular myopathy (STM) and limb girdle muscular dystrophy type 2H (LGMD2H) was demonstrated, as both are caused by the p D487N missense mutation in TRIM32 originally found in the Manitoba Hutterite population. Recently, three novel homozygous TRIM32 mutations have been described in LGMD patients. Here we describe a three generation Swedish family clinically presenting with limb girdle muscular weakness and histological features of a microvacuolar myopathy. The two index patients were compound heterozygotes for a frameshift mutation in TRIM32 (c.1560delC ) and a 30 kb intragenic deletion, encompassing parts of intron 1 and the entire exon 2 of TRIM32. In these patients, no full-length or truncated TRIM32 could be detected. Interestingly, heterozygous family members carrying only one mutation showed mild clinical symptoms and vacuolar changes in muscle. In our family, the phenotype encompasses additionally a mild demyelinating polyneuropathic syndrome. Thus STM and LGMD2H are the result of loss of function mutations that can be either deletions or missense mutations. (c) 2009 Wiley-Liss, Inc.
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| 19. |
- Borg, Mattias, et al.
(författare)
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Geometric model for metalorganic vapour phase epitaxy of dense nanowire arrays
- 2013
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Ingår i: Journal of Crystal Growth. - : Elsevier BV. - 0022-0248. ; 366, s. 15-19
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Tidskriftsartikel (refereegranskat)abstract
- We propose a geometric model to estimate the contribution of substrate surface diffusion to growth of dense nanowire arrays using metalorganic vapour phase epitaxy. It is shown that the nanowire mantle area becomes the most significant collector of growth material when the nanowire diameter is large and the inter-nanowire pitch is small. It is concluded that this growth regime is important for the array geometries typically used for optoelectronic and photovoltaic applications of nanowires. The growth rate under these conditions is also not constant with time, due to the growing nanowire mantle area. This result was confirmed by experiments in which dense arrays of InAs nanowires were grown and the nanowire growth rate was measured as a function of time. (C) 2013 Elsevier B.V. All rights reserved.
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| 20. |
- Borg, Markus, et al.
(författare)
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SZZ unleashed: an open implementation of the SZZ algorithm : featuring example usage in a study of just-in-time bug prediction for the Jenkins project
- 2019
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Konferensbidrag (refereegranskat)abstract
- Machine learning applications in software engineering often rely on detailed information about bugs. While issue trackers often contain information about when bugs were fixed, details about when they were introduced to the system are often absent. As a remedy, researchers often rely on the SZZ algorithm as a heuristic approach to identify bug-introducing software changes. Unfortunately, as reported in a recent systematic literature review, few researchers have made their SZZ implementations publicly available. Consequently, there is a risk that research effort is wasted as new projects based on SZZ output need to initially reimplement the approach. Furthermore, there is a risk that newly developed (closed source) SZZ implementations have not been properly tested, thus conducting research based on their output might introduce threats to validity. We present SZZ Unleashed, an open implementation of the SZZ algorithm for git repositories. This paper describes our implementation along with a usage example for the Jenkins project, and conclude with an illustrative study on just-in-time bug prediction. We hope to continue evolving SZZ Unleashed on GitHub, and warmly invite the community to contribute.
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| 21. |
- Dubrovskii, Vladimir G., et al.
(författare)
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Length Distributions of Nanowires Growing by Surface Diffusion
- 2016
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 16:4, s. 2167-2172
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Tidskriftsartikel (refereegranskat)abstract
- We present experimental data on the time and radius-dependent length distributions of Au-catalyzed InAs nanowires grown by metal organic vapor phase epitaxy. We show that these distributions are not as sharp as commonly believed. Rather, they appear to be much broader than Poissonian from the very beginning and spread quickly as the nanowires grow. We develop a model that attributes the observed broadening to the diffusion-induced character of growth. In the initial growth stage, the nanowires are fed from their entire length, leading to a Polya-like length distribution whose standard deviation is proportional to the mean length. After the nanowire length exceeds the adatom diffusion length, the growth acquires a Poissonian character in which the standard deviation scales as a square root of the mean length. We explain why wider nanowires have smaller length dispersion and speculate on the length distributions in Au-catalyzed versus self-catalyzed growth methods.
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| 22. |
- Flyckt, Lena, et al.
(författare)
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Aberrant tyrosine transport across the fibroblast membrane in patients with schizophrenia : indications of maternal inheritance
- 2011
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Ingår i: Journal of Psychiatric Research. - : Pergamon Press. - 0022-3956 .- 1879-1379. ; 45:4, s. 519-525
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Tidskriftsartikel (refereegranskat)abstract
- Background: In previous studies of the present patients with schizophrenia, aberrant tyrosine transport across the fibroblast membrane was found. A low K(m), a kinetic factor indicating high affinity between tyrosine and the binding site at the cell membrane, was found to be associated with poor cognitive functions in patients. The present study aimed at investigating possible relationships between patients with schizophrenia and their first-degree relatives in aberrant tyrosine transport indicating that it may be a biological marker for the genetic susceptibility. Methods: Thirty-three parents, 13 fathers and 20 mothers, from 23 families with a schizophrenic patient agreed to enter the study. They underwent skin biopsies for fibroblast cultivation, neuropsychological and psychiatric investigations and were classified as family history positive or negative. Tyrosine transport kinetics (K(m) and V(max)) were calculated from in vitro trials of gradients of extracellular tyrosine concentrations in fibroblast cultures. Results: An association between patients with schizophrenia and their mothers were found for a low K(m) indicating maternal inheritance. Mothers displaying a low K(m) performed worse on the neuropsychological tests compared to mothers with normal K(m). Corresponding relationships between a low K(m) and neurocognitive dysfunction had previously been found for the patients. Conclusions: An aberrant tyrosine transport across plasma membrane may constitute a biological marker for an endophenotype within the schizophrenia spectrum with low cognitive functioning. A plausible mode for genetic transmission is maternal inheritance. (C) 2010 Elsevier Ltd. All rights reserved.
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| 23. |
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| 24. |
- Gonzalez, Henrik, et al.
(författare)
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Identification of novel candidate protein biomarkers for the post-polio syndrome — Implications for diagnosis, neurodegeneration and neuroinflammation
- 2009
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Ingår i: Journal of Proteomics. - : Elsevier BV. - 1874-3919 .- 1876-7737. ; 71:6, s. 670-681
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Tidskriftsartikel (refereegranskat)abstract
- Survivors of poliomyelitis often develop increased or new symptoms decades after the acute infection, a condition known as post-polio syndrome (PPS). The condition affects 20-60% of previous polio patients, making it one of the most common causes of neurological deficits worldwide. The underlying pathogenesis is not fully understood and accurate diagnosis is not feasible. Herein we investigated whether it was possible to identify proteomic profile aberrations in the cerebrospinal fluid (CSF) of PPS patients. CSF from 15 patients with well-defined PPS were analyzed for protein expression profiles. The results were compared to data obtained from nine healthy controls and 34 patients with other non-inflammatory diseases which served as negative controls. In addition, 17 samples from persons with secondary progressive multiple sclerosis (SPMS) were added as relevant age-matched references for the PPS samples. The CSF of persons with PPS displayed a disease-specific and highly predictive (p=0.0017) differential expression of five distinct proteins: gelsolin, hemopexin, peptidylglycine alpha-amidating monooxygenase, glutathione synthetase and kallikrein 6, respectively, in comparison with the control groups. An independent ELISA confirmed the increase of kallikrein 6. We suggest that these five proteins should be further evaluated as candidate biomarkers for the diagnosis and development of new therapies for PPS patients.
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| 25. |
- Gonzalez, Henrik, et al.
(författare)
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Intravenous immunoglobulin for post-polio syndrome: a randomised controlled trial
- 2006
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Ingår i: Lancet Neurol. ; 5:6, s. 493-500
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Survivors of poliomyelitis often develop increased or new symptoms decades after the acute infection, known as post-polio syndrome. Production of proinflammatory cytokines within the CNS indicates an underlying inflammatory process, accessible for immunomodulatory treatment. We did a multicentre, randomised, double-blind, placebo-controlled study of intravenous immunoglobulin in post-polio syndrome. METHODS: 142 patients at four university clinics were randomly assigned infusion of either 90 g in total of intravenous immunoglobulin (n=73) or placebo (n=69) during 3 consecutive days, repeated after 3 months. Seven patients were withdrawn from the study. Thus, 135 patients were assessed per protocol. Primary endpoints were muscle strength in a selected study muscle and quality of life as measured with the SF-36 questionnaire (SF-36 PCS). Secondary endpoints were 6-minute walk test (6MWT), timed up and go (TUG), muscle strength in muscles not chosen as the study muscle, physical activity scale of the elderly (PASE), visual analogue scale (VAS) for pain, multidimensional fatigue inventory (MFI-20), balance, and sleep quality. Outcome tests were done immediately before the first infusion and 3 months after the second infusion. This study is registered with , number NCT00160082. FINDINGS: Compared with baseline, median muscle strength differed by 8.3% between patients receiving intravenous immunoglobulin and placebo, in favour of the treatment group (p=0.029). SF-36 PCS did not differ significantly between the groups after treatment (p=0.321). Differences in the subscale vitality score (p=0.042) and PASE (p=0.018) favoured the active treatment group. MFI-20, TUG, muscle strength in the muscles not chosen as the study muscle, 6MWT, balance, and sleep quality did not differ between groups. For the whole study population there was no significant change in pain, as determined by VAS. Nevertheless, patients who reported pain at the study start improved in the intervention group but not in the placebo group (p=0.037). Intravenous immunoglobulin was well tolerated. INTERPRETATION: Intravenous immunoglobulin could be a supportive treatment option for subgroups of patients with post-polio syndrome. Further studies on responding subgroups, long-term effects, and dosing schedules are needed.
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| 26. |
- Gonzalez, Henrik, et al.
(författare)
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Management of postpolio syndrome
- 2010
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Ingår i: Lancet Neurology. - : The Lancet Publishing Group. - 1474-4422 .- 1474-4465. ; 9:6, s. 634-642
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Tidskriftsartikel (refereegranskat)abstract
- Postpolio syndrome is characterised by the exacerbation of existing or new health problems, most often muscle weakness and fatigability, general fatigue, and pain, after a period of stability subsequent to acute polio infection. Diagnosis is based on the presence of a lower motor neuron disorder that is supported by neurophysiological findings, with exclusion of other disorders as causes of the new symptoms. The muscle-related effects of postpolio syndrome are possibly associated with an ongoing process of denervation and reinnervation, reaching a point at which denervation is no longer compensated for by reinnervation. The cause of this denervation is unknown, but an inflammatory process is possible. Rehabilitation in patients with postpolio syndrome should take a multiprofessional and multidisciplinary approach, with an emphasis on physiotherapy, including enhanced or individually modified physical activity, and muscle training. Patients with postpolio syndrome should be advised to avoid both inactivity and overuse of weak muscles. Evaluation of the need for orthoses and assistive devices is often required.
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| 27. |
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| 28. |
- Gorschek, Tony, et al.
(författare)
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A controlled empirical evaluation of a requirements abstraction model
- 2007
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Ingår i: Information and Software Technology. - Newton, MA : Elsevier BV. - 0950-5849 .- 1873-6025. ; 49:7, s. 790-805
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Tidskriftsartikel (refereegranskat)abstract
- Requirement engineers in industry are faced with the complexity of handling large amounts of requirements as development moves from traditional bespoke projects towards market-driven development. There is a need for usable and useful models that recognize this reality and support the engineers in a continuous effort of choosing which requirements to accept and which to dismiss off hand using the goals and product strategies put forward by management. This paper presents an evaluation of such a model that is built based on needs identified in industry. The evaluation's primary goal is to test the model's usability and usefulness in a lab environment prior to large scale industry piloting, and is a part of a large technology transfer effort. The evaluation uses 179 subjects from three different Swedish Universities, which is a large portion of the university students educated in requirements engineering in Sweden during 2004 and 2005. The results provide a strong indication that the model is indeed both useful and usable and ready for industry trials. © 2006 Elsevier B.V. All rights reserved.
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| 29. |
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| 30. |
- Jonsson, Leif, et al.
(författare)
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Automated Bug Assignment: Ensemble-based Machine Learning in Large Scale Industrial Contexts
- 2015
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Ingår i: Empirical Software Engineering. - : Springer Science and Business Media LLC. - 1573-7616 .- 1382-3256. ; 21:4
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Tidskriftsartikel (refereegranskat)abstract
- Bug report assignment is an important part of software maintenance. In particular, incorrect assignments of bug reports to development teams can be very expensive in large software development projects. Several studies propose automating bug assignment techniques using machine learning in open source software contexts, but no study exists for large-scale proprietary projects in industry. The goal of this study is to evaluate automated bug assignment techniques that are based on machine learning classification. In particular, we study the state-of-the-art ensemble learner Stacked Generalization (SG) that combines several classifiers. We collect more than 50,000 bug reports from five development projects from two companies in different domains. We implement automated bug assignment and evaluate the performance in a set of controlled experiments. We show that SG scales to large scale industrial application and that it outperforms the use of individual classifiers for bug assignment, reaching prediction accuracies from 50 % to 89 % when large training sets are used. In addition, we show how old training data can decrease the prediction accuracy of bug assignment. We advice industry to use SG for bug assignment in proprietary contexts, using at least 2,000 bug reports for training. Finally, we highlight the importance of not solely relying on results from cross-validation when evaluating automated bug assignment.
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| 31. |
- Knutson, Hans-Kristian, et al.
(författare)
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Experimental productivity rate optimization of rare earth element separation through preparative solid phase extraction chromatography.
- 2014
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Ingår i: Journal of Chromatography A. - : Elsevier BV. - 0021-9673. ; 1348, s. 47-51
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Tidskriftsartikel (refereegranskat)abstract
- Separating individual rare earth elements from a complex mixture with several elements is difficult and this is emphasized for the middle elements: Samarium, Europium and Gadolinium. In this study we have accomplished an overloaded one-step separation of these rare earth elements through preparative ion-exchange high-performance liquid chromatography with an bis (2-ethylhexyl) phosphoric acid impregnated column and nitric acid as eluent. An inductively coupled plasma mass spectrometry unit was used for post column element detection. The main focus was to optimize the productivity rate, subject to a yield requirement of 80% and a purity requirement of 99% for each element, by varying the flow rate and batch load size. The optimal productivity rate in this study was 1.32kgSamarium/(hmcolumn(3)), 0.38kgEuropium/(hmcolumn(3)) and 0.81kgGadolinium/(hmcolumn(3)).
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| 32. |
- Larsson, Lars, 1952-, et al.
(författare)
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Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease
- 2008
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Ingår i: American Journal of Physiology - Cell Physiology. - : American Physiological Society. - 0363-6143 .- 1522-1563. ; 295:3, s. 722-731
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Tidskriftsartikel (refereegranskat)abstract
- Slow troponin T (TnT) plays an indispensable role in skeletal muscle function. Alternative RNA splicing in the NH2-terminal region produces high-molecular-weight (HMW) and low-molecular-weight (LMW) isoforms of slow TnT. Normal adult slow muscle fibers express mainly HMW slow TnT. Charcot-Marie-Tooth disease (CMT) is a group of inherited peripheral polyneuropathies caused by various neuronal defects. We found in the present study that LMW slow TnT was significantly upregulated in demyelination form type 1 CMT (CMT1) but not axonal form type 2 CMT (CMT2) muscles. Contractility analysis showed an increased specific force in single fibers isolated from CMT1 but not CMT2 muscles compared with control muscles. However, an in vitro motility assay showed normal velocity of the myosin motor isolated from CMT1 and CMT2 muscle biopsies, consistent with their unchanged myosin isoform contents. Supporting a role of slow TnT isoform regulation in contractility change, LMW and HMW slow TnT isoforms showed differences in the molecular conformation in conserved central and COOH-terminal regions with changed binding affinity for troponin I and tropomyosin. In addition to providing a biochemical marker for the differential diagnosis of CMT, the upregulation of LMW slow TnT isoforms under the distinct pathophysiology of CMT1 demonstrates an adaptation of muscle function to neurological disorders by alternative splicing modification of myofilament proteins.
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| 33. |
- Melin, Eva, et al.
(författare)
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Normal serum levels of immune complexes in postpolio patients
- 2014
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Ingår i: Results in Immunology. - : Elsevier BV. - 2211-2839. ; 4, s. 54-57
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:The pathophysiology of the postpolio syndrome is not fully understood. Increased cytokine levels in cerebrospinal fluid and peripheral blood indicate a systemic inflammatory process. Decreased cytokine levels and the clinical effect of intravenous immunoglobulin treatment further indicate an inflammatory/immunological pathogenesis. The aim of the present study was to evaluate whether an autoimmune process follows the initial infection, by means of analyzing immune complexes.PATIENTS AND METHODS:Circulating immune complexes were analyzed from blood samples of 20 postpolio patients and 95 healthy controls. To compensate for differences in age between patients and controls, a sub-analysis was performed using only the 30 oldest controls. Tumor necrosis factor-inducing properties of polyethylene glycol-precipitated immune complexes were compared between the postpolio patients and 10 healthy controls.RESULTS:When comparing levels in postpolio patients to the whole control group, including the 30 oldest investigated, there were no statistically significant differences. No difference was found in tumor necrosis factor levels induced by immune complexes when comparing patients and controls.CONCLUSIONS:There was no increase in circulating immune complex or in tumor necrosis factor-inducing effects of circulating immune complex between postpolio patients and healthy controls, indicating that the postpolio syndrome is not due to an autoimmune reaction.
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| 34. |
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| 35. |
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| 36. |
- Möller, Marika, et al.
(författare)
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Cognitive dysfunction in post-COVID-19 condition : mechanisms, management, and rehabilitation
- 2023
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Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 294:5, s. 563-581
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Forskningsöversikt (refereegranskat)abstract
- The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed. Risk factors for developing PCC, with or without cognitive impairments, include advanced age, preexisting medical conditions, and the severity of acute illness. The underlying mechanisms remain unclear, but proposed contributors include neuroinflammation, hypoxia, vascular damage, and latent virus reactivation not excluding the possibility of direct viral invasion of the central nervous system, illustrating complex viral pathology. As the individual variation of the cognitive impairments is large, a neuropsychological examination and a person-centered multidimensional approach are required. According to the World Health Organization, limited evidence on COVID-19-related cognitive impairments necessitates implementing rehabilitation interventions from established practices of similar conditions. Psychoeducation and compensatory skills training are recommended. Assistive products and environmental modifications adapted to individual needs might be helpful. In specific attention- and working memory dysfunctions, cognitive training—carefully monitored for intensity—might be effective for people who do not suffer from post-exertional malaise. Further research is crucial for evidence-based interventions specific to COVID-19-related cognitive impairments.
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| 37. |
- Patel, Mikael, et al.
(författare)
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A Case Study in Assessing and Improving Capacity Using an Anatomy of Good Practice
- 2007
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Ingår i: The 6th joint meeting of the European Software Engineering Conference and the ACM SIGSOFT Symposium on the Foundations of Software Engineering (ESEC/FSE 2007), Dubrovnik, Croatia. - New York : ACM. - 9781595938114 ; , s. 509-512
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Konferensbidrag (refereegranskat)abstract
- Capacity in telecommunication systems is highly related to operator revenue. As a vendor of such systems, Ericsson AB is continuously improving its processes for estimating, specifying, tuning, and testing the capacity of delivered systems. In order to systematize process improvements Ericsson AB and Linköping University joined forces to create an anatomy of Capacity Sub Processes (CSPs). The anatomy is the result of an interview series conducted to document good practices amongst organizations active in capacity improvement. In this paper we analyze four different development processes in terms of how far they have reached in their process maturity according to our anatomy and show possible improvement directions. Three of the processes are currently in use at Ericsson, and the fourth is the OpenUP/Basic process which we have used as a reference process in earlier research. We also include an analysis of the observed good practices. The result mainly confirms the order of CSPs in the anatomy, but we need to use our information of the maturity of products and the major life cycle in the organization in order to fully explain the role of the anatomy in planning of improvements.
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| 38. |
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| 39. |
- Svahnberg, Mikael, et al.
(författare)
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Perspectives on Requirements Understandability : for Whom Does the Teacher's Bell Toll?
- 2008
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Konferensbidrag (refereegranskat)abstract
- Software development decision makers use many different information sources as a basis for their decisions. One of these sources is the requirements specification, which is used in a large number of processes throughout the software development cycle. In order to make good decisions, the quality and completeness of the available information is important. Hence, requirements must be written in a way that is understandable for the different decision makers. However, requirements are rarely written with an explicit perception of how to make them understandable for different target usages. In this study we investigate the implicit assumptions of current and future requirements engineers and their teachers regarding which usages they perceive as most important when creating requirements. This is contrasted with industrial viewpoints of the relative importance of different requirements usages. The results indicate that the teachers and future requirements engineers have a strong focus towards in-project perspectives, and very little in common with the perspectives of industry managers. Thus, we are training students to serve as software developers, and not software engineering managers.
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| 40. |
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| 41. |
- Wallensten, Johanna, et al.
(författare)
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Isoforms of soluble vascular endothelial growth factor in stress-related mental disorders : a cross-sectional study
- 2021
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Vascular endothelial growth factor (VEGF) has been implicated in the pathophysiology of stress-related mental disorders. However, VEGF levels have seldom been compared across mental disorders and never by isoforms. Pathophysiological processes involving leakage of astrocyte-derived extracellular vesicles (EVs) across the blood–brain barrier could be associated with VEGF levels in patients with stress-related mental disorders. This cross-sectional study compared plasma levels of VEGF121, VEGF165, and VEGF121 + VEGF165 (VEGFtotal) in patients with stress-induced exhaustion disorder (SED) (n = 31), patients with major depressive disorder (MDD) (n = 31), and healthy controls (n = 61). It also analyzed the correlation between VEGF and astrocyte-derived EVs in plasma. An enzyme-linked immunosorbent assay (ELISA) was used to measure VEGF121 and VEGF165 in citrate plasma, and flow cytometry was used to measure astrocyte-derived EVs in plasma. The mean concentration of soluble VEGF121 (sVEGF121) was significantly higher in patients with SED than healthy controls (P = 0.043). Mean sVEGF165 was significantly lower in patients with MDD than patients with SED (P = 0.004) or healthy controls (P = 0.037). Mean sVEGFtotal was significantly higher in patients with SED than in patients with MDD (P = 0.021) and also higher in patients with SED than healthy controls (P = 0.040). Levels of sVEGF121 were positively correlated with levels of astrocyte-derived EVs only in patients with SED (P = 0.0128). The same was true of levels of sVEGFtotal and astrocyte-derived EVs (P = 0.0046). Differing levels of VEGF isoforms may reflect different pathophysiological mechanisms in SED and MDD. Further research is needed to better understand the potential roles of VEGF isoforms and astrocyte-derived EVs in mental disorders.
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| 42. |
- Wallensten, Johanna, et al.
(författare)
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Plasma levels of S100B and neurofilament light chain protein in stress-related mental disorders
- 2022
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- The pathophysiological changes underlying stress-related mental disorders remain unclear. However, research suggests that alterations in astrocytes and neurons may be involved. This study examined potential peripheral markers of such alterations, including S100B and neurofilament light chain (NF-L). We compared plasma levels of S100B and NF-L in patients with chronic stress-induced exhaustion disorder (SED), patients with major depressive disorder (MDD), and healthy controls. We also investigated whether levels of S100B and NF-L correlated with levels of astrocyte-derived extracellular vesicles (EVs that indicate astrocyte activation or apoptosis) and with symptom severity. Only women had measurable levels of S100B. Women with SED had higher plasma levels of S100B than women with MDD (P < 0.001) and healthy controls (P < 0.001). Self-rated symptoms of cognitive failures were positively correlated with levels of S100B (r(s) = 0.434, P = 0.005) as were depressive symptoms (r(s) = 0.319, P < 0.001). Plasma levels of astrocyte-derived EVs were correlated with levels of S100B (r(s) = 0.464, P < 0.001). Plasma levels of NF-L did not differ between the groups and were not correlated with symptom severity or EV levels. Thus, long-term stress without sufficient recovery and SED may be associated with raised plasma levels of S100B, which may be evidence of pathophysiological changes in astrocytes. The findings also support the hypothesis that plasma levels of S100B are associated with cognitive dysfunction.
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| 43. |
- Werhagen, Lars, et al.
(författare)
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Medical complication in adults with spina bifida
- 2013
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Ingår i: Clinical neurology and neurosurgery. - : Elsevier. - 0303-8467 .- 1872-6968. ; 115:8, s. 1226-1229
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Tidskriftsartikel (refereegranskat)abstract
- SETTING: Cohort study.INTRODUCTION: Spina bifida (SB) is a congenital malformation affecting the central nervous system (CNS) and is one of the most prevalent CNS disorders in children. Hydrocephalus (HC) is present in 80% of newborns with SB. The aim of the present study was to analyze the medical complications and to relate the complications to age at examination, the level of injury, AIS grade and presence of HC in adults with SB.MATERIALS AND METHODS: SB patients were recruited from the Spinalis out-patient clinic at the Karolinska University Hospital at their annual follow-up. The patients underwent a thorough general and neurological examination and background data including medical complications were retrieved from the medical files.RESULTS: 127 of 157 (82%) SB patients (114 with MMC and 13 SB occulta) with a mean age of 34 years were included. Half of the patients had a complete SCI and a lumbar level was most common. Nearly 60% of the patients had HC. 88 patients (69%) suffered from at least one medical complication. Urinary tract infection (UTI), scoliosis and pain were the most common complications found in 46%, 30% and 28% of the patients, respectively. Less common complications were epilepsy, pressure ulcers (PU) and spasticity.DISCUSSION: SB gives a disability including motor, sensory dysfunctions and the patients suffer from a high frequency of medical complications like UTI, scoliosis, pain, and epilepsy. Data gives basis for adequate routines for medical examination at the follow-up.
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| 44. |
- Wändell, Per, et al.
(författare)
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The risk of post-polio syndrome among immigrant groups in Sweden
- 2023
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Ingår i: Scientific Reports. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- To examine the risk of post-polio syndrome (PPS) in immigrant groups using native Swedish-born individuals as referents. This is a retrospective study. The study population included all individuals aged 18 years and older registered in Sweden. PPS was defined as having at least one registered diagnosis in the Swedish National Patient Register. The incidence of post-polio in different immigrant groups, using Swedish-born individuals as referents, was assessed by Cox regression, with hazard ratios (HRs) and 99% confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, co-morbidities, and neighbourhood socioeconomic status. In total 5300 post-polio cases were registered, 2413 males and 2887 females. Fully adjusted HRs (99% CI) in immigrants versus Swedish-born were 1.77 in men (1.52–2.07) and 1.39 (1.19–1.62) in women. Statistically significant excess risks of post-polio were found in the following subgroups: men and women from Africa, HRs (with 99% CI) 7.40 (5.17–10.59) and 8.39 (5.44–12.95), respectively, and Asia, HRs 6.32 (5.11–7.81) and 4.36 (3.38–5.62) respectively, and in men from Latin America, HR 3.66 (2.17–6.18). It is of importance to be aware of risks of PPS in immigrants settled in Western countries, and that it is more common in immigrants from regions of the world where polio is still prevalent. Patients with PPS need treatment and proper follow-up until polio has been eradicated through global vaccination programs.
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| 45. |
- Östlund, Gunilla, et al.
(författare)
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Post polio syndrome: fatigued patients a specific subgroup?
- 2011
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Ingår i: Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1651-2081 .- 1650-1977. ; 43:1, s. 39-45
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Tidskriftsartikel (refereegranskat)abstract
- To examine the characteristics of fatigued and non-fatigued post-polio patients and to define potential subgroups across the fatigue continuum.
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| 46. |
- Östlund, Gunilla, et al.
(författare)
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Vitality among Swedish patients with post-polio: a physiological phenomenon.
- 2008
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Ingår i: Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1651-2081 .- 1650-1977. ; 40:9, s. 709-14
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate vitality and fatigue in post-polio patients, and the relative contributions of physiological and psychological parameters to the level of vitality. DESIGN: Multi-centre study. SUBJECTS: One hundred and forty-three patients with post-polio syndrome. METHODS: Inventories of background, quality of life, fatigue and sleep quality were used. Pain was evaluated using a visual analogue scale. Descriptive statistics and correlations were used for all selected parameters. Hierarchical regression models were constructed to examine predictors of variations in vitality, pain, reduced activity and physical fatigue. RESULTS: General fatigue accounted for 68% of the variation in vitality. Of this, 91% was accounted for by physiological indicators. After controlling for age, physiological para notmeters accounted for 56.6% and 25%, if entered before and after the psychological parameters, respectively. The impact of the psychological parameters decreased after accounting for the physiological parameters. Physical fatigue, age and sleep quality were associated with variation in pain. Body mass index, pain and sleep quality accounted for differences in reduced activity and physical fatigue. CONCLUSION: Vitality in post-polio patients depends on physio-logical parameters. Mental fatigue is not a prominent predictor. Subgroups with or without fatigue, independent of age, need further study.
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