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Träfflista för sökning "WFRF:(Bowers Daniel C.) "

Sökning: WFRF:(Bowers Daniel C.)

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Numrering	Referens	Omslagsbild	Hitta
1.	Arnison, Paul G., et al. (författare) Ribosomally synthesized and post-translationally modified peptide natural products : overview and recommendations for a universal nomenclature 2013 Ingår i: Natural product reports (Print). - : Royal Society of Chemistry (RSC). - 0265-0568 .- 1460-4752. ; 30:1, s. 108-160 Forskningsöversikt (refereegranskat)abstract This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
2.	Lee, James J, et al. (författare) Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 2018 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 50:8, s. 1112-1121 Tidskriftsartikel (refereegranskat)abstract Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1million individuals and identify 1,271independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
3.	Campbell, Brittany B., et al. (författare) Comprehensive Analysis of Hypermutation in Human Cancer 2017 Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 171:5 Tidskriftsartikel (refereegranskat)abstract © 2017 Elsevier Inc. We present an extensive assessment of mutation burden through sequencing analysis of > 81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load. Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation. Mutagens, such as UV light, were implicated in unexpected cancers, including sarcomas and lung tumors. The order of mutational signatures identified previous treatment and germline replication repair deficiency, which improved management of patients and families. These data will inform tumor classification, genetic testing, and clinical trial design. A large-scale analysis of hypermutation in human cancers provides insights into tumor evolution dynamics and identifies clinically actionable mutation signatures.

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Resultat 1-3 av 3

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Typ av publikation: tidskriftsartikel (2); forskningsöversikt (1)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Jacobsson, Bo, 1960 (1); Göransson, Ulf (1); Craik, David J. (1); Johannesson, Magnus (1); Campbell, Harry (1); Light, Nicholas (1); visa fler...; Oskarsson, Sven, 197 ... (1); Wareham, Nicholas J. (1); Koellinger, Philipp ... (1); Langenberg, Claudia (1); Magnusson, Patrik K ... (1); Lee, James J. (1); Pursell, Zachary F (1); Wu, Yang (1); Sivonen, Kaarina (1); Luan, Jian'an (1); Metspalu, Andres (1); Wilson, James F. (1); Liu, Wen (1); Li, Hui (1); Severinov, Konstanti ... (1); Cesarini, David (1); Arnison, Paul G. (1); Bibb, Mervyn J. (1); Bierbaum, Gabriele (1); Bowers, Albert A. (1); Bugni, Tim S. (1); Bulaj, Grzegorz (1); Camarero, Julio A. (1); Campopiano, Dominic ... (1); Challis, Gregory L. (1); Clardy, Jon (1); Cotter, Paul D. (1); Dawson, Michael (1); Dittmann, Elke (1); Donadio, Stefano (1); Dorrestein, Pieter C ... (1); Entian, Karl-Dieter (1); Fischbach, Michael A ... (1); Garavelli, John S. (1); Gruber, Christian W. (1); Haft, Daniel H. (1); Hemscheidt, Thomas K ... (1); Hertweck, Christian (1); Hill, Colin (1); Horswill, Alexander ... (1); Jaspars, Marcel (1); Kelly, Wendy L. (1); Klinman, Judith P. (1); Kuipers, Oscar P. (1); visa färre...

Lärosäte: Göteborgs universitet (2); Uppsala universitet (2); Handelshögskolan i Stockholm (1); Karolinska Institutet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2); Naturvetenskap (1)

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