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- Bellander, M, et al.
(författare)
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Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement
- 2011
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Ingår i: NEUROPSYCHOLOGIA. - : Elsevier BV. - 0028-3932 .- 1873-3514. ; 49:7, s. 1938-1942
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Tidskriftsartikel (refereegranskat)abstract
- LMX1A is a transcription factor involved in the development of dopamine (DA)-producing neurons in midbrain. Previous research has shown that allelic variations in three LMX1A single nucleotide polymorphisms (SNPs) were related to risk of Parkinson's disease (PD), suggesting that these SNPs may influence the number of mesencephalic DA neurons. Prompted by the established link between striatal DA functions and working memory (WM) performance, we examined two of these SNPs in relation to the ability to benefit from 4 weeks of WM training. One SNP (rs4657412) was strongly associated with the magnitude of training-related gains in verbal WM. The allele linked to larger gains has previously been suggested to be associated with higher dopaminergic nerve cell density. No differential gains of either SNP were observed for spatial WM, and the genotype groups were also indistinguishable in tests of attention, interference control, episodic memory, perceptual speed, and reasoning for both SNPs. This pattern of data is in agreement with previous findings from our group, suggesting that cognitive effects of DA-related genes may be more easily detected in a training context than for single-assessment performance scores.
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| 15. |
- Brehmer, M, et al.
(författare)
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Consultation on UTUC Stockholm 2018
- 2019
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Ingår i: World journal of urology. - : Springer Science and Business Media LLC. - 1433-8726 .- 0724-4983. ; 37:11, s. 2269-2270
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 16. |
- Brehmer, M, et al.
(författare)
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Consultation on UTUC Stockholm 2022
- 2023
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Ingår i: World journal of urology. - 1433-8726. ; 41:12, s. 3393-3394
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Brehmer, M, et al.
(författare)
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Heat-induced apoptosis in human prostatic stromal cells
- 2000
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Ingår i: BJU International. - 1464-4096 .- 1464-410X. ; 85:4, s. 535-541
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To determine whether heat, used in transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia and which causes necrotic lesions within the adenoma, induces apoptosis in benign human prostatic stromal cells. Materials and methods. Prostatic stromal cells were cultured from benign human prostatic tissue. The origin of the cells was identified by immunohistochemical staining and transmission electron microscopy. Cell cultures were exposed to moderate hyperthermia (47░C) for 1 h and any apoptosis detected by light microscopy, transmission electron microscopy and the measurement of induced caspase-3-like activity. Results. The cultures contained a mixed population of smooth muscle cells and myofibroblasts. Twenty-four hours after heat exposure, 76% of the cells were apoptotic and the caspase activity had increased, whereas only 14% of the cells were necrotic. Conclusion. Moderate hyperthermia induces apoptosis in cultured human prostatic stromal cells.
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| 19. |
- Brehmer, M
(författare)
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Reflections on personalized management of UTUC
- 2018
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Ingår i: World journal of urology. - : Springer Science and Business Media LLC. - 1433-8726 .- 0724-4983. ; 36:7, s. 1177-1178
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Kaminorz, Y., et al.
(författare)
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Characteristics of polythiophene surface light emitting diodes
- 2000
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Ingår i: Synthetic metals. - 0379-6779 .- 1879-3290. ; 113:1, s. 103-114
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Tidskriftsartikel (refereegranskat)abstract
- Surface light emitting diodes (SLEDs), in which previously microfabricated electrodes were coated with a conjugated polymer, were made with greatly different electrode spacings (250 nm and 10 or 20 µm) and with different electrode material combinations. The fabrication process allowed us to compare several electrode materials. The SLED structures also enabled imaging of the light emission zone with fluorescence video microscopy. Conventional sandwich structures were also made for comparison (electrode separation 50 nm). In this study, the emitting layer was poly[3-(2',5'-bis(1?,4?,7?trioxaoctyl)phenyl)- 2,2'-bithiophene] (EO-PT), a conjugated polymer based on polythiophene with oligo(ethyleneoxide) side chains. The current-voltage (I(V)) and light-voltage (L(V)) characteristics of the SLEDs were largely insensitive to electrode separation except at high voltages, at which the current in the devices with the largest separations was limited. Sandwich structures had the same light output at a given current. Light could be obtained in forward and reverse bias from indium tin oxide (ITO)-aluminum, gold silicide-aluminum, and gold silicide-gold SLEDs, but the turn-on voltages were lowest with the ITO-aluminum devices, and these were also the brightest and most reliable. Adding salt to the EO-PT increased the current and brightness, decreased the turn-on voltages, and made the I(V) characteristics symmetric, thus, a device with an electrode separation of 10 µm had the extraordinarily low turn-on voltage of 6 V. The location of the light emission was at the electron-injecting contact.
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| 32. |
- Knutsson, K, et al.
(författare)
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Pathoses associated with mandibular third molars subjected to removal
- 1996
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Ingår i: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS. - : MOSBY-YEAR BOOK INC. ; 82:1
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objectives. To measure the prevalence oi disease of mandibular third molars referred for removal and to estimate the risk for development of pathoses for two cues. Study design. A prospective cohort study on molars subjected to removal was performed. The
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- Mattli, Florentina, et al.
(författare)
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Prospective memory across the lifespan : investigating the contribution of retrospective and prospective processes
- 2014
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Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 21:5, s. 515-543
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Tidskriftsartikel (refereegranskat)abstract
- Prospective memory performance follows an inverted U-shaped function across the lifespan. Findings on the relative contribution of purely prospective memory and retrospective memory processes within prospective memory to this trajectory are scarce and inconclusive. We analyzed age-related differences in prospective memory performance across the lifespan in a cross-sectional design including six age groups (N = 99, 7–83 years) and investigated possible mechanisms by experimentally disentangling the relative contributions of retrospective memory and purely prospective memory processes. Results confirmed the inverted U-shaped function of prospective memory performance across the lifespan. A significant interaction between process type and age group was observed indicating differential relative contributions of retrospective memory and purely prospective memory processes on the development of prospective memory performance. Our results showed that mainly the pure prospective memory processes within prospective memory lead to lower prospective memory performance in young children and old adults. Moreover, the relative contributions of the retrospective memory and purely prospective memory processes are not uniform at both ends of the lifespan, i.e., in later adulthood the purely prospective memory processes seem to determine performance to an even greater extent than in childhood. Nevertheless, age effects were also observed in the retrospective component which thus contributed to the prospective memory performance differences between the age groups.
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- Nikolic, S, et al.
(författare)
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Cardiovascular and Lung Involvement in Patients with Autoimmune Pancreatitis
- 2020
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Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 9:2
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct histopathological subtypes, namely: lymphoplasmacytic sclerosing pancreatitis (AIP type 1) and idiopathic duct-centric pancreatitis (AIP type 2). Lung involvement and aortic involvement have been reported in 12% and 9% of patients with systemic IgG4-RD, respectively. In series including patients with AIP, both lung and aortic involvement were described in 2% of the patients. Most of the epidemiological data come from Japan, and there is a lack of information from Europe, especially the Scandinavian countries. Patients and methods: We performed a single-centre retrospective study on a prospectively collected cohort of patients diagnosed with AIP at the Department for Digestive Diseases at Karolinska University Hospital in Stockholm, Sweden, from 2004 to 2019. Demographic and clinical data were collected from the medical charts. Results: One hundred and thirty-three patients with AIP were analysed. Six patients were excluded because they lacked some of the clinical data relevant to the study. Demographic and clinical features of 127 patients were presented. There were 98 patients with AIP type 1-35 (35.7%) female and 63 (64.3%) male, with a mean age of 55.4 ± 18.2. Among them, 15 (15.3%) patients had lung and/or cardiovascular involvement-11 (11.2%) patients had lung involvement, 10 (10.2%) patients had cardiovascular involvement (six patients had both). Most of them (67.0%) had never smoked. The mean follow-up time of the patients with AIP type 1 was 49 months. Conclusions: Lung and/or cardiovascular involvement were diagnosed in 15 (15.3%) patients in our historical cohort of patients with AIP type 1. Most of the lung involvement was presented in the form of nodular lesions in the lungs, non-specific infiltrates, “ground-glass” appearance with pleura thickening, and effusion. Aortic involvement was a major form of vascular involvement in patients with AIP, as in previous published studies on patients with IgG4-RD.
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- Radecka, Eva, et al.
(författare)
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Pelvicaliceal biomodeling as an aid to achieving optimal access in percutaneous nephrolithotripsy
- 2006
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Ingår i: Journal of endourology. - 0892-7790 .- 1557-900X. ; 20:2, s. 92-101
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To investigate prospectively the benefits of three-dimensional stereolithographic biomodeling produced from CT data as an aid to achieving optimal access for percutaneous nephrolithotripsy (PCNL). PATIENTS AND METHODS: Eight patients with complex urinary calculi were selected. Multislice CT scans of the kidney in native and excretory phases were acquired with the patient in the prone position to simulate the position during surgery. Contiguous reconstructed slices were produced from the data volume. The data of interest were processed to transform them into a format acceptable for production of a biomodel. Exact plastic replicas of the pelvicaliceal system and the calculi were created and used for morphologic assessment, preoperative planning, patient education, and surgical navigation. RESULTS: The survey results were based on subjective opinions rather than objective data. The biomodels enhanced the ability to visualize a patient's unique anatomy before surgery. This aided the planning and rehearsal of endourologic procedures. CONCLUSION: Although this study is only a preliminary investigation, we postulate that biomodeling has the advantage of allowing imaging data to be displayed in a physical form. In difficult cases, this technique may improve treatment, operative planning, and communication with colleagues and patients. The limitations of the technology include the manufacturing time and cost, but more accurate puncture-site selection may reduce costs by saving operating time.
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