| 1. |
- Pelikan, Daniel, 1985-
(författare)
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Searches for a Charged Higgs Boson in ATLAS and Development of Novel Technology for Future Particle Detector Systems
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The discovery of a charged Higgs boson (H±) would be a clear indication for physics beyond the Standard Model. This thesis describes searches for charged Higgs bosons with the ATLAS experiment at CERN’s Large Hadron Collider (LHC). The first data collected during the LHC Run 1 is analysed, searching for a light charged Higgs boson (mH±<mtop), which decays predominantly into a tau-lepton and a neutrino. Different final states with one or two leptons (electrons or muons), as well as leptonically or hadronically decaying taus, are studied, and exclusion limits are set.The background arising from misidentified non-prompt electrons and muons was estimated from data. This so-called "Matrix Method'' exploits the difference in the lepton identification between real, prompt, and misidentified or non-prompt electrons and muons. The Matrix Method is used in all charged Higgs boson searches in this thesis.In 2024 the LHC will be upgraded into a High Luminosity LHC (HL-LHC). The ATLAS detector is expected to collect around 300 fb-1 of collision data until 2022, whereas the HL-LHC will deliver about 250-300 fb-1 of data per year. This will increase the mean number of interactions per bunch crossing, resulting in larger particle fluxes. This puts challenging requirements on the electronics. In order to keep trigger and data rates at manageable levels, new trigger concepts require more intelligence at early stage which possibly results in more cables and connectors, inside the detector which lead to degraded performance of the detector system.This thesis presents new concepts using wireless technology at 60 GHz, in order add more data links inside the detector system without adding much material. Patch antennas have been developed, operating at 60 GHz. Manufacture methods have been investigated, and the fabrication tolerances and bandwidth of these antennas have been studied. Also, concepts of using passive repeaters have been investigated, to make the 60 GHz signal pass boundaries. These repeaters can be used to connect intelligence inside the detector, but also for reading out data from the whole detector radially.
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- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 7. |
- Bokan, Petar
(författare)
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Pair production of Higgs bosons in the final state with bottom quarks and τ leptons in the ATLAS experiment : Search results using LHC Run 2 data and prospect studies at the HL-LHC
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- After the discovery of the Higgs boson, the ultimate test of the electroweak symmetry breaking and the Standard Model (SM) of particle physics is to establish evidence of Higgs boson self-coupling, which can be achieved by searching for pair production of Higgs bosons. In addition, many theories beyond the SM predict heavy resonances that could decay into pairs of Higgs bosons. A search for non-resonant and resonant pair production of Higgs bosons in the final state with two bottom quarks and two τ leptons (bb̄τ+ τ−) is presented for 36.1 fb-1 of proton-proton collision data at a centre-of-mass energy of 13 TeV recorded by the ATLAS experiment at the Large Hadron Collider (LHC). The observed (expected) 95% confidence level (CL) upper limit on the non-resonant Higgs boson pair production cross-section times the bb̄τ+τ- branching ratio corresponds to 12.7 (14.8) times the SM prediction. The ratio of the Higgs boson self-coupling to its SM expectation, κλ, is observed (expected) to be constrained to κλ ∈ [-7.4, 15.7] ([-8.9, 16.8]) at 95% CL. The sensitivity is extrapolated to a 14 TeV centre-of-mass energy and 3000 fb-1, which is the target integrated luminosity of the High-Luminosity LHC (HL-LHC). Various extrapolation assumptions are taken into account. The estimated expected signal significance for the SM Higgs boson pair production in the bb̄τ+τ- final state at the HL-LHC reaches 2.1 standard deviations, while the expected allowed κλ interval is κλ ∈ [-0.8, 8.8] at 95% CL, assuming the SM Higgs boson couplings. Furthermore, potential improvements of the analysis techniques are discussed in the context of searches for pair production of Higgs bosons with the full Run 2 ATLAS data.
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| 8. |
- Carninci, P, et al.
(författare)
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The transcriptional landscape of the mammalian genome
- 2005
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 309:5740, s. 1559-1563
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Tidskriftsartikel (refereegranskat)abstract
- This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
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| 10. |
- Coignard, J, et al.
(författare)
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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 1078-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
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| 19. |
- Ferreira, MA, et al.
(författare)
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Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1741-
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
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| 20. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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| 29. |
- Martinsson, Per, 1971-
(författare)
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Structural Information Content of the Optical Field
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The communication modes are a mathematical technique for the description of structural information in optical fields. These modes are orthogonal, optimally connected functions characteristic of the optical system. Mathematically they are obtained by the singular value decomposition (SVD) of the operator that represents the field propagation. In this dissertation, the foundations of the technique are described, and the theory is extended and applied to a variety of specific systems. In the Fresnel regime, the communication modes are closely related to the prolate spheroidal wavefunctions (PSWF). Within this approximation, the numerical propagation of the field in a one-dimensional optical system in terms of the PSWFs is demonstrated and the problem of assessing the best achievable realization of a given target field is addressed. Simplified equations for field propagation are presented. Approximate modes in large-aperture systems are derived and shown to agree with Gabor's theory on optics and information. The longitudinal resolution of an axicon is analyzed in terms of the communication modes. It is shown that in a generalized axicon geometry the communication modes are expressible in terms of the PSWFs, and that in usual circumstances a version of the large aperture approximation applies, resulting in quadratic waves in the aperture domain and sinc functions in the image domain Eigenequations for the communication modes in scalar near-field diffraction are derived and applied to a simplified scanning near-field optical microscope (SNOM) geometry. It is suggested that the resolution of a SNOM system is essentially given by the width of the lowest-order communication modes. The best-connected mode is shown to effectively reduce to the Green function. Within the context of random fluctuations the communication modes are defined for the cross-spectral density of partially coherent fields. These modes are compared to the well-known coherent modes. Expressions for the effective degree of coherence are derived, and it is demonstrated that optical fields of any state of coherence may readily be propagated through deterministic systems by means of the communication modes. Results are illustrated numerically in an optical near-field geometry. The communication modes theory is further extended to vector diffraction on the basis of Maxwell's equations. The polarization properties of the electromagnetic communication modes as represented by the Stokes parameters are analyzed numerically for an example of a near-field geometry.The work presented in this dissertation shows that the communication modes are an advanced, versatile tool that can be applied to deterministic and random, scalar and electromagnetic optical systems in far-field and near-field arrangements. The method is likely to find further uses in applications such as polarization microscopy.
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| 33. |
- Thomas, M, et al.
(författare)
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Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity
- 2023
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expanded PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS were 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1,681-3,651 cases and 8,696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They were significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values<0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
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