| 1. |
- Dommersnes, Paul Gunnar, 1971, et al.
(författare)
-
Marangoni transport in lipid nanotubes
- 2005
-
Ingår i: Europhysics Letters. - : IOP Publishing. - 0295-5075 .- 1286-4854. ; 70:2, s. 271-277
-
Tidskriftsartikel (refereegranskat)abstract
- We give a simple picture of transient and stationary transport in lipid nanotubes connecting two vesicles, when a difference of membrane tension is imposed at time t = 0, either by pressing one vesicle with a micro-fiber, or by adding a surplus of membrane lipid. The net result is a transport of membrane from the tense towards the floppy vesicle. In the early stage, the tube remains cylindrical, and the gradient of surface tension gives rise to two opposite flows of the internal liquid: a Marangoni flow towards the direction of high tension, and a Poiseuille flow (induced by Laplace pressures) in the opposite direction. At longer time, the tube reaches a stationary state, where curvature and Laplace pressure are balanced. Marangoni flows dominate for giant vesicles, where Laplace pressure is negligible.
|
|
| 2. |
- Charles-Orszag, A, et al.
(författare)
-
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting
- 2018
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 4450-
-
Tidskriftsartikel (refereegranskat)abstract
- The shape of cellular membranes is highly regulated by a set of conserved mechanisms that can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that we term ‘one-dimensional’ membrane wetting. We provide a theoretical model that describes the physical basis of one-dimensional wetting and show that this mechanism occurs in model membranes interacting with nanofibers, and in human cells interacting with extracellular matrix meshworks. We propose one-dimensional wetting as a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococci during infection.
|
|
