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- Borg, Markus, et al.
(författare)
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Evaluation of Traceability Recovery in Context: A Taxonomy for Information Retrieval Tools
- 2012
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Ingår i: 16th International Conference on Evaluation & Assessment in Software Engineering (EASE 2012). - : IET. - 9781849195416 ; , s. 111-120
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Konferensbidrag (refereegranskat)abstract
- Background: Development of complex, software intensive systems generates large amounts of information. Several researchers have developed tools implementing information retrieval (IR) approaches to suggest traceability links among artifacts. Aim: We explore the consequences of the fact that a majority of the evaluations of such tools have been focused on benchmarking of mere tool output. Method: To illustrate this issue, we have adapted a framework of general IR evaluations to a context taxonomy specifically for IR-based traceability recovery. Furthermore, we evaluate a previously proposed experimental framework by conducting a study using two publicly available tools on two datasets originating from development of embedded software systems. Results: Our study shows that even though both datasets contain software artifacts from embedded development, the characteristics of the two datasets differ considerably, and consequently the traceability outcomes. Conclusions: To enable replications and secondary studies, we suggest that datasets should be thoroughly characterized in future studies on traceability recovery, especially when they can not be disclosed. Also, while we conclude that the experimental framework provides useful support, we argue that our proposed context taxonomy is a useful complement. Finally, we discuss how empirical evidence of the feasibility of IR-based traceability recovery can be strengthened in future research.
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| 2. |
- Ingvarsson, Jonas, 1966, et al.
(författare)
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The New Order of Criticism. Explorations of Book Reviews Between the Interpretative and Algorithmic
- 2022
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Ingår i: CEUR Workshop Proceedings. - Aachen : CEUR-WS. ; , s. 228-234
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Konferensbidrag (refereegranskat)abstract
- The New Order of Criticism (2020-2024) is a mixed-methods project combining algorithmic and interpretative approaches to the study of literary criticism. The project expands on a prior study of Swedish book reviews from the years 1906, 1956 and 2006 ('The Order of Criticism', Samuelsson 2013), re-examining and re-evaluating the original results through the use of computational tools, language technology and big data. The aim of the present paper is to discuss early experiences and results from the interdisciplinary approach utilized by the current project, a collaborative process where interpreter and programmer are in dialogue, and where methodologies, and their instantiation in tools, are reflexively discussed from an epistemological point of view. In our analysis we ask: How can insights from working with digital methodologies and tools inform traditional scholarship on literary criticism? How can interpretative approaches and results inform digital methods?.
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| 5. |
- Ny, Lina, et al.
(författare)
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The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice
- 2020
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Ingår i: Cell Death and Disease. - : Springer Nature. - 2041-4889. ; 11:12
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Tidskriftsartikel (refereegranskat)abstract
- Wound healing is a complex physiologic process that proceeds in overlapping, sequential steps. Plasminogen promotes fibrinolysis and potentiates the inflammatory response during wound healing. We have tested the hypothesis that the novel plasminogen receptor, Plg-RKT, regulates key steps in wound healing. Standardized burn wounds were induced in mice and time dependence of wound closure was quantified. Healing in Plg-RKT−/− mice was significantly delayed during the proliferation phase. Expression of inflammatory cytokines was dysregulated in Plg-RKT−/− wound tissue. Consistent with dysregulated cytokine expression, a significant delay in wound healing during the proliferation phase was observed in mice in which Plg-RKT was specifically deleted in myeloid cells. Following wound closure, the epidermal thickness was less in Plg-RKT−/− wound tissue. Paradoxically, deletion of Plg-RKT, specifically in keratinocytes, significantly accelerated the rate of healing during the proliferation phase. Mechanistically, only two genes were upregulated in Plg-RKT−/− compared with Plg-RKT+/+ wound tissue, filaggrin, and caspase 14. Both filaggrin and caspase 14 promote epidermal differentiation and decrease proliferation, consistent with more rapid wound closure and decreased epidermal thickness during the remodeling phase. Fibrin clearance was significantly impaired in Plg-RKT−/− wound tissue. Genetic reduction of fibrinogen levels to 50% completely abrogated the effect of Plg-RKT deletion on the healing of burn wounds. Remarkably, the effects of Plg-RKT deletion on cytokine expression were modulated by reducing fibrinogen levels. In summary, Plg-RKT is a new regulator participating in different phases of cutaneous burn wound healing, which coordinately plays a role in the interrelated responses of inflammation, keratinocyte migration, and fibrinolysis.
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| 6. |
- Sulniute, Rima, et al.
(författare)
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Plasminogen is a critical regulator of cutaneous wound healing
- 2016
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Ingår i: Thrombosis and Haemostasis. - 0340-6245 .- 2567-689X. ; 115:5, s. 1001-1009
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Tidskriftsartikel (refereegranskat)abstract
- Wound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completion of wound healing and is a known reason for formation of chronic wounds. Previous studies have shown that wound closure is delayed in plasminogen deficient mice, and a role for plasminogen in dissection of extracellular matrix was suggested. However, our finding that plasminogen is transported to the wound by inflammatory cells early during the healing process, where it potentiates inflammation, indicates that plasminogen may also have other roles in the wound healing process. Here we report that plasminogen-deficient mice have extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation. Delayed formation of granulation tissue suggests that fibroblast function is impaired in the absence of plasminogen. Therefore, in addition to its role in the activation of inflammation, plasminogen is also crucial for subsequent steps, including resolution of inflammation and activation of the proliferation phase. Importantly, supplementation of plasminogen-deficient mice with human plasminogen leads to a restored healing process that is comparable to that in wild-type mice. Besides of being an activator of the inflammatory phase during wound healing, plasminogen is also required for the subsequent termination of inflammation. Based on these results, we propose that plasminogen may be an important future therapeutic agent for wound treatment.
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