| 1. |
- Su, Zhan, et al.
(författare)
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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:10
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Tidskriftsartikel (refereegranskat)abstract
- Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (Pcombined=4.09×10(-9); odds ratio (OR)=1.21, 95% confidence interval (CI)=1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (Pcombined=2.74×10(-10); OR=1.14, 95% CI=1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus.
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| 2. |
- Achtert, Peggy, et al.
(författare)
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Properties of Arctic liquid and mixed-phase clouds from shipborne Cloudnet observations during ACSE 2014
- 2020
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 20:23, s. 14983-15002
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Tidskriftsartikel (refereegranskat)abstract
- This study presents Cloudnet retrievals of Arctic clouds from measurements conducted during a 3-month research expedition along the Siberian shelf during summer and autumn 2014. During autumn, we find a strong reduction in the occurrence of liquid clouds and an increase for both mixed-phase and ice clouds at low levels compared to summer. About 80 % of all liquid clouds observed during the research cruise show a liquid water path below the infrared black body limit of approximately 50 g m(-2). The majority of mixed-phase and ice clouds had an ice water path below 20 g m(-2). Cloud properties are analysed with respect to cloud-top temperature and boundary layer structure. Changes in these parameters have little effect on the geometric thickness of liquid clouds while mixed-phase clouds during warm-air advection events are generally thinner than when such events were absent. Cloud-top temperatures are very similar for all mixed-phase clouds. However, more cases of lower cloudtop temperature were observed in the absence of warm-air advection. Profiles of liquid and ice water content are normalized with respect to cloud base and height. For liquid water clouds, the liquid water content profile reveals a strong increase with height with a maximum within the upper quarter of the clouds followed by a sharp decrease towards cloud top. Liquid water content is lowest for clouds observed below an inversion during warm-air advection events. Most mixedphase clouds show a liquid water content profile with a very similar shape to that of liquid clouds but with lower maximum values during events with warm air above the planetary boundary layer. The normalized ice water content profiles in mixed-phase clouds look different from those of liquid water content. They show a wider range in maximum values with the lowest ice water content for clouds below an inversion and the highest values for clouds above or extending through an inversion. The ice water content profile generally peaks at a height below the peak in the liquid water content profile - usually in the centre of the cloud, sometimes closer to cloud base, likely due to particle sublimation as the crystals fall through the cloud.
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| 3. |
- Brooks, Ian M., et al.
(författare)
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The Turbulent Structure of the Arctic Summer Boundary Layer During The Arctic Summer Cloud-Ocean Study
- 2017
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Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 122:18, s. 9685-9704
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Tidskriftsartikel (refereegranskat)abstract
- The mostly ice covered Arctic Ocean is dominated by low-level liquid-or mixed-phase clouds. Turbulence within stratocumulus is primarily driven by cloud top cooling that induces convective instability. Using a suite of in situ and remote sensing instruments we characterize turbulent mixing in Arctic stratocumulus, and for the first time we estimate profiles of the gradient Richardson number at relatively high resolution in both time (10 min) and altitude (10 m). It is found that the mixing occurs both within the cloud, as expected, and by wind shear instability near the surface. About 75% of the time these two layers are separated by a stably stratified inversion at 100-200 m altitude. Exceptions are associated with low cloud bases that allow the cloud-driven turbulence to reach the surface. The results imply that turbulent coupling between the surface and the cloud is sporadic or intermittent.Plain Language Summary: The lower atmosphere over the summertime Arctic Ocean often consists of two well-mixed layers-a surface mixed layer and a cloud mixed layer-that are separated by a weak decoupling layer at about 100 to 300 m above the surface. In these cases, the cloud cannot interact directly with the surface. Large-scale forecast and climate models consistently fail to reproduce this observed structure and may thus fail to correctly reproduce the cloud properties and the amount of energy absorbed by or emitted from the surface as solar and infrared radiation. This contributes to errors in reproducing changes in sea ice concentration over time. Here we use measurements made in the central Arctic to study the processes controlling whether or not the cloud is coupled to the surface. The effect of wind at the surface is found not to be a controlling factor. The depth of the cloud mixed layer is critical, but the multiple processes influencing it cannot be separated using the data available here. However, cooling at cloud top by infrared radiation is key, as is the extension of cloud into the temperature inversion-a unique feature of Arctic clouds.
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| 4. |
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| 5. |
- Cummins, Donald P., et al.
(författare)
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Reducing Parametrization Errors for Polar Surface Turbulent Fluxes Using Machine Learning
- 2024
-
Ingår i: Boundary-layer Meteorology. - : Springer. - 0006-8314 .- 1573-1472. ; 190:3
-
Tidskriftsartikel (refereegranskat)abstract
- Turbulent exchanges between sea ice and the atmosphere are known to influence the melting rate of sea ice, the development of atmospheric circulation anomalies and, potentially, teleconnections between polar and non-polar regions. Large model errors remain in the parametrization of turbulent heat fluxes over sea ice in climate models, resulting in significant uncertainties in projections of future climate. Fluxes are typically calculated using bulk formulae, based on Monin-Obukhov similarity theory, which have shown particular limitations in polar regions. Parametrizations developed specifically for polar conditions (e.g. representing form drag from ridges or melt ponds on sea ice) rely on sparse observations and thus may not be universally applicable. In this study, new data-driven parametrizations have been developed for surface turbulent fluxes of momentum, sensible heat and latent heat in the Arctic. Machine learning has already been used outside the polar regions to provide accurate and computationally inexpensive estimates of surface turbulent fluxes. To investigate the feasibility of this approach in the Arctic, we have fitted neural-network models to a reference dataset (SHEBA). Predictive performance has been tested using data from other observational campaigns. For momentum and sensible heat, performance of the neural networks is found to be comparable to, and in some cases substantially better than, that of a state-of-the-art bulk formulation. These results offer an efficient alternative to the traditional bulk approach in cases where the latter fails, and can serve to inform further physically based developments.
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| 6. |
- Ferrari, Raffaele, et al.
(författare)
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Frontotemporal dementia and its subtypes: a genome-wide association study.
- 2014
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Ingår i: Lancet Neurology. - 1474-4465. ; 13:7, s. 686-699
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Tidskriftsartikel (refereegranskat)abstract
- Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72-have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder.
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| 7. |
- Hollestelle, Antoinette, et al.
(författare)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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| 8. |
- Sotiropoulou, Georgia, et al.
(författare)
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Atmospheric conditions during the Arctic Clouds in Summer Experiment (ACSE) : Contrasting open-water and sea-ice surfaces during melt and freeze-up seasons
- 2016
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Ingår i: Journal of Climate. - 0894-8755 .- 1520-0442. ; 29:24, s. 8721-8744
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Tidskriftsartikel (refereegranskat)abstract
- The Arctic Clouds in Summer Experiment (ACSE) was conducted during summer and early autumn 2014, providing a detailed view of the seasonal transition from ice melt into freeze-up. Measurements were taken over both ice-free and ice-covered surfaces, near the ice edge, offering insight to the role of the surface state in shaping the atmospheric conditions. The initiation of the autumn freeze-up was related to a change in air mass, rather than to changes in solar radiation alone; the lower atmosphere cooled abruptly leading to a surface heat loss. During melt season, strong surface inversions persisted over the ice, while elevated inversions were more frequent over open water. These differences disappeared during autumn freeze-up, when elevated inversions persisted over both ice-free and ice-covered conditions. These results are in contrast to previous studies that found a well-mixed boundary layer persisting in summer and an increased frequency of surface-based inversions in autumn, suggesting that our knowledge derived from measurements taken within the pan-Arctic area and on the central ice-pack does not necessarily apply closer to the ice-edge. This study offers an insight to the atmospheric processes that occur during a crucial period of the year; understanding and accurately modeling these processes is essential for the improvement of ice-extent predictions and future Arctic climate projections.
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| 9. |
- Srivastava, Piyush, et al.
(författare)
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Ship-based estimates of momentum transfer coefficient over sea ice and recommendations for its parameterization
- 2022
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 22:7, s. 4763-4778
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Tidskriftsartikel (refereegranskat)abstract
- A major source of uncertainty in both climate projections and seasonal forecasting of sea ice is inadequate representation of surface–atmosphere exchange processes. The observations needed to improve understanding and reduce uncertainty in surface exchange parameterizations are challenging to make and rare. Here we present a large dataset of ship-based measurements of surface momentum exchange (surface drag) in the vicinity of sea ice from the Arctic Clouds in Summer Experiment (ACSE) in July–October 2014, and the Arctic Ocean 2016 experiment (AO2016) in August–September 2016. The combined dataset provides an extensive record of momentum flux over a wide range of surface conditions spanning the late summer melt and early autumn freeze-up periods, and a wide range of atmospheric stabilities. Surface exchange coefficients are estimated from in situ eddy covariance measurements. The local sea-ice fraction is determined via automated processing of imagery from ship-mounted cameras. The surface drag coefficient, CD10n, peaks at local ice fractions of 0.6–0.8, consistent with both recent aircraft-based observations and theory. Two state-of-the-art parameterizations have been tuned to our observations, with both providing excellent fits to the measurements.
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| 10. |
- Tjernström, Michael, et al.
(författare)
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Warm-air advection, air mass transformation and fog causes rapid ice melt
- 2015
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Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 42:13, s. 5594-5602
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Tidskriftsartikel (refereegranskat)abstract
- Direct observations during intense warm-air advection over the East Siberian Sea reveal a period of rapid sea-ice melt. A semistationary, high-pressure system north of the Bering Strait forced northward advection of warm, moist air from the continent. Air-mass transformation over melting sea ice formed a strong, surface-based temperature inversion in which dense fog formed. This induced a positive net longwave radiation at the surface while reducing net solar radiation only marginally; the inversion also resulted in downward turbulent heat flux. The sum of these processes enhanced the surface energy flux by an average of similar to 15Wm(-2) for a week. Satellite images before and after the episode show sea-ice concentrations decreasing from > 90% to similar to 50% over a large area affected by the air-mass transformation. We argue that this rapid melt was triggered by the increased heat flux from the atmosphere due to the warm-air advection.
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| 11. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 12. |
- Baccarini, Andrea, et al.
(författare)
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Frequent new particle formation over the high Arctic pack ice by enhanced iodine emissions
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- In the central Arctic Ocean the formation of clouds and their properties are sensitive to the availability of cloud condensation nuclei (CCN). The vapors responsible for new particle formation (NPF), potentially leading to CCN, have remained unidentified since the first aerosol measurements in 1991. Here, we report that all the observed NPF events from the Arctic Ocean 2018 expedition are driven by iodic acid with little contribution from sulfuric acid. Iodic acid largely explains the growth of ultrafine particles (UFP) in most events. The iodic acid concentration increases significantly from summer towards autumn, possibly linked to the ocean freeze-up and a seasonal rise in ozone. This leads to a one order of magnitude higher UFP concentration in autumn. Measurements of cloud residuals suggest that particles smaller than 30nm in diameter can activate as CCN. Therefore, iodine NPF has the potential to influence cloud properties over the Arctic Ocean. Which vapors are responsible for new particle formation in the Arctic is largely unknown. Here, the authors show that the formation of new particles at the central Arctic Ocean is mainly driven by iodic acid and that particles smaller than 30nm in diameter can activate as cloud condensation nuclei.
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| 13. |
- Betz, Stefanie, et al.
(författare)
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Lessons Learned from Developing a Sustainability Awareness Framework for Software Engineering Using Design Science
- 2024
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Ingår i: ACM Transactions on Software Engineering and Methodology. - 1049-331X .- 1557-7392. ; 33:5
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Tidskriftsartikel (refereegranskat)abstract
- To foster a sustainable society within a sustainable environment, we must dramatically reshape our work and consumption activities, most of which are facilitated through software. Yet, most software engineers hardly consider the effects on the sustainability of the IT products and services they deliver. This issue is exacerbated by a lack of methods and tools for this purpose. Despite the practical need for methods and tools that explicitly support consideration of the effects that IT products and services have on the sustainability of their intended environments, such methods and tools remain largely unavailable. Thus, urgent research is needed to understand how to design such tools for the IT community properly. In this article, we describe our experience using design science to create the Sustainability Awareness Framework (SusAF), which supports software engineers in anticipating and mitigating the potential sustainability effects during system development. More specifically, we identify and present the challenges faced during this process. The challenges that we have faced and addressed in the development of the SusAF are likely to be relevant to others who aim to create methods and tools to integrate sustainability analysis into their IT products and services development. Thus, the lessons learned in SusAF development are shared for the benefit of researchers and other professionals who design tools for that end.
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| 14. |
- Birch, Cathryn, et al.
(författare)
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The performance of a global and mesoscale model over the central Arctic Ocean during the summer melt season
- 2009
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Ingår i: Journal of Geophysical Research : Atmospheres. ; 114, s. D13104-
-
Tidskriftsartikel (refereegranskat)abstract
- Measurements of turbulent fluxes, clouds, radiation, and profiles of meanmeteorological parameters, obtained over an ice floe in the central Arctic Ocean during theArctic Ocean Experiment 2001, are used to evaluate the performance of U.K. Met OfficeUnified Model (MetUM) and Coupled Ocean/Atmosphere Mesoscale Prediction System(COAMPS) in the lower atmosphere during late summer. Both the latest version of theMetUM and the version operational in 2001 are used in the comparison to gain aninsight as to whether updates to the model have improved its performance over the Arcticregion. As with previous model evaluations over the Arctic, the pressure, humidity,and wind fields are satisfactorily represented in all three models. The older version of theMetUM underpredicts the occurrence of low-level Arctic clouds, and the liquid and icecloud water partitioning is inaccurate compared to observations made during SHEBA.In the newer version, simulated ice and liquid water paths are improved, but theoccurrence of low-level clouds are overpredicted. Both versions overestimate the amountof radiative heat absorbed at the surface, leading to a significant feedback of errorsinvolving the surface albedo, which causes a large positive bias the surface temperature.Cloud forcing in COAMPS produces similar biases in the downwelling shortwave andlongwave radiation fluxes to those produced by UM(G25). The surface albedoparameterization is, however, more realistic, and thus, the total heat flux and surfacetemperature are more accurate for the majority of the observation period.
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| 15. |
- Brooks, Ian, et al.
(författare)
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Assessing Sustainability Impacts ofSystems: SuSAF andtheSDGs
- 2023
-
Ingår i: Communications in Computer and Information Science. - 1865-0929 .- 1865-0937.
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Konferensbidrag (refereegranskat)abstract
- The United Nations Sustainable Development Goals (SDGs) identify key topics where action is required to transform our world towards sustainability. We call for the extensive integration of the SDGs into Software Engineering to support this transformation. This will require the creation of methods and tools for the analysis of software system impacts on the SDGs. To show how this integration might be achieved, we report on a mapping to the SDGs from an existing software sustainability assessment tool, the Sustainability Assessment Framework (SusAF). We find that there is a good mapping between SusAF and the SDGs but that mapping to some specific SDG targets may be dependant on the expertise of the analysts. Mapping of case study systems will be needed for empirical validation.
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| 16. |
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| 17. |
- Brooks, Ian, et al.
(författare)
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Tech4Bad in the Oil and Gas Industry : Exploring Choices for ICT Professionals
- 2023
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 142-153
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Konferensbidrag (refereegranskat)abstract
- Fossil fuels contribute 86% of the anthropogenic greenhouse gas emissions driving climate change. These emissions must decline rapidly every year to reach Net Zero by 2050 in order to stay within internationally agreed limits for climate change. The oil and gas industry makes extensive use of information and communication technology (ICT) to run their business of supplying these fuels. In this paper, we investigate the role of ICT in the oil and gas industry, and explore how ICT professionals might reason about their involvement in this deeply unsustainable sector. Through a scoping review, we find that ICT is an essential enabler of the fossil fuel sector with ICT budgets in USD billions and tens of thousands of ICT staff. We map out case studies of collective action against unethical corporate practices and survey pragmatic and ethical bases for deciding whether to leave or stay in the oil and gas industry. Using reports from the activity of ICT professionals, we identify patterns for action. The results show that there are important gaps in the literature on the role of ICT in the oil and gas industry. To counter this, we propose a research agenda to better understand the extent to which ICT enables this damaging industry ("Tech4Bad") and how ICT professionals think about their role within it.
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| 18. |
- Brooks, Ian, et al.
(författare)
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#Tech4Bad: when do we say no?
- 2021
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Ingår i: ITNOW. - : Oxford University Press (OUP). - 1746-5702 .- 1746-5710. ; 63:4, s. 14-15
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Existing IT systems are enabling company activities that are unsustainable and damaging to the environment. ‘When should we as IT professionals stop maintaining them?’ ask Ian Brooks MBCS, Minna Laurell Thorslund, Aksel Biørn-Hansen and Elena Somova.
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| 19. |
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| 20. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 21. |
- Coyne, Karin S, et al.
(författare)
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The prevalence of chronic constipation and faecal incontinence among men and women with symptoms of overactive bladder.
- 2011
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Ingår i: BJU International. - 1464-410X. ; 107:2, s. 254-261
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Tidskriftsartikel (refereegranskat)abstract
- Study Type - Symptom prevalence (non-consecutive cohort) Level of Evidence 4 OBJECTIVE To estimate the prevalence and overlap of overactive bladder (OAB), chronic constipation (CC) and faecal incontinence (FI) among a general population sample of adults in the USA. MATERIALS AND METHODS A cross-sectional internet-based survey of randomly selected panel members who were >/=40 years of age was conducted. Participants reported how often they experienced symptoms of OAB, CC and FI using Likert scales and modified Rome III criteria. Analyses were conducted to examine the overall prevalence of OAB, CC and FI in men and women separately and to characterize the extent of overlap between these conditions in participants with OAB vs those without OAB, and those participants with continent vs incontinent OAB. RESULTS The response rate for the survey was 62.2% and the final sample (N= 2000) included 927 men and 1073 women. The overall prevalence of OAB [defined as a response of >/='sometimes' to urinary urgency (i.e. 'sometimes' or more often) or 'yes' to urinary urgency incontinence (UUI)] was 26.1% in men and 41.2% in women. The overall prevalence of CC was significantly lower in men than in women (15.3 vs 26.3%), but both men and women with OAB were significantly more likely to report CC (22.3 and 35.9% vs 5.7 and 6.7%, respectively, P < 0.0001). The overall prevalence of FI reported 'rarely' or more was 16.7% of men and 21.9% of women. Men and women with OAB were significantly more likely to report FI than those without OAB. FI was also more common in participants with incontinent OAB than in those with continent OAB. Logistic regressions controlling for demographic factors and comorbid conditions suggest that OAB status is a very strong predictor of CC, FI and overlapping CC and FI (odds ratios, range 3.55-7.96). CONCLUSIONS Chronic constipation, FI and overlapping CC and faecal incontinence occur more frequently in patients with OAB and should be considered when evaluating and treating patients with OAB. These findings suggest a shared pathophysiology among these conditions. Additional study is needed to determine if successful treatment of one or more of these conditions is accompanied by commensurate improvement in symptoms referable to the other organ system.
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| 22. |
- Gardner, Michael, et al.
(författare)
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Gender and telomere length : Systematic review and meta-analysis
- 2014
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Ingår i: Experimental Gerontology. - : Elsevier. - 0531-5565 .- 1873-6815. ; 51, s. 15-27
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Forskningsöversikt (refereegranskat)abstract
- Background: It is widely believed that females have longer telomeres than males, although results from studies have been contradictory. Methods: We carried out a systematic review and meta-analyses to test the hypothesis that in humans, females have longer telomeres than males and that this association becomes stronger with increasing age. Searches were conducted in EMBASE and MEDLINE (by November 2009) and additional datasets were obtained from study investigators. Eligible observational studies measured telomeres for both females and males of any age, had a minimum sample size of 100 and included participants not part of a diseased group. We calculated summary estimates using random-effects meta-analyses. Heterogeneity between studies was investigated using sub-group analysis and meta-regression. Results: Meta-analyses from 36 cohorts (36,230 participants) showed that on average females had longer telomeres than males (standardised difference in telomere length between females and males 0.090, 95% CI 0.015, 0.166; age-adjusted). There was little evidence that these associations varied by age group (p = 1.00) or cell type (p = 0.29). However, the size of this difference did vary by measurement methods, with only Southern blot but neither real-time PCR nor Flow-FISH showing a significant difference. This difference was not associated with random measurement error. Conclusions: Telomere length is longer in females thanmales, although this difference was not universally found in studies that did not use Southern blot methods. Further research on explanations for the methodological differences is required. (C) 2013 Published by Elsevier Inc.
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| 23. |
- Heldal, Rogardt, 1964, et al.
(författare)
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Sustainability competencies and skills in software engineering: An industry perspective
- 2024
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Ingår i: Journal of Systems and Software. - 0164-1212. ; 211
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Tidskriftsartikel (refereegranskat)abstract
- Context: Achieving the UN Sustainable Development Goals (SDGs) demands a shift by industry, governments, society, and individuals to reach adequate levels of awareness and actions to address sustainability challenges. Software systems will play an important role in moving towards these targets. Sustainability skills are necessary to support the development of software systems and to provide sustainable IT-supported services for citizens. Gap: While there is a growing number of academic bodies including sustainability education in engineering and computer science curricula, there is not yet comprehensive research on the competencies and skills required by IT professionals to develop such systems. Research goal: This study aims to identify the industrial sustainability needs for education and training from software engineers’ perspective. For this, we answer the following questions: (1) what are the interests of organisations with an IT division with respect to sustainability? (2) what do organisations want to achieve with respect to sustainability, and how? and (3) what are the sustainability-related competencies and skills that organisations need to achieve their sustainability goals? Methodology: We conducted a qualitative study with interviews and focus groups with experts from twenty-eight organisations with an IT division from nine countries to understand their interests, goals, and achievements related to sustainability, and the skills and competencies needed to achieve their goals. Results: Our findings show that organisations are interested in sustainability, both idealistically and increasingly for core business reasons. They seek to improve the sustainability of software processes and products but encounter difficulties, like the trade-off between short-term financial profitability and long-term sustainability goals or an unclear understanding of sustainability concepts from a software engineering perspective. To fill these gaps, they have promoted in-house training courses, collaborated with universities, and sent employees to external training. The acquired competencies should support translating environmental and social benefits into economic ones and make sustainability an integral part of software development.
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| 24. |
- Heldal, Rogardt, 1964, et al.
(författare)
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Sustainability competencies and skills in software engineering: An industry perspective
- 2024
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Ingår i: Journal of Systems and Software. - 0164-1212. ; 211
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Tidskriftsartikel (refereegranskat)abstract
- Context: Achieving the UN Sustainable Development Goals (SDGs) demands a shift by industry, governments, society, and individuals to reach adequate levels of awareness and actions to address sustainability challenges. Software systems will play an important role in moving towards these targets. Sustainability skills are necessary to support the development of software systems and to provide sustainable IT-supported services for citizens. Gap: While there is a growing number of academic bodies including sustainability education in engineering and computer science curricula, there is not yet comprehensive research on the competencies and skills required by IT professionals to develop such systems. Research goal: This study aims to identify the industrial sustainability needs for education and training from software engineers’ perspective. For this, we answer the following questions: (1) what are the interests of organisations with an IT division with respect to sustainability? (2) what do organisations want to achieve with respect to sustainability, and how? and (3) what are the sustainability-related competencies and skills that organisations need to achieve their sustainability goals? Methodology: We conducted a qualitative study with interviews and focus groups with experts from twenty-eight organisations with an IT division from nine countries to understand their interests, goals, and achievements related to sustainability, and the skills and competencies needed to achieve their goals. Results: Our findings show that organisations are interested in sustainability, both idealistically and increasingly for core business reasons. They seek to improve the sustainability of software processes and products but encounter difficulties, like the trade-off between short-term financial profitability and long-term sustainability goals or an unclear understanding of sustainability concepts from a software engineering perspective. To fill these gaps, they have promoted in-house training courses, collaborated with universities, and sent employees to external training. The acquired competencies should support translating environmental and social benefits into economic ones and make sustainability an integral part of software development.
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| 25. |
- Karlsson, Linn, et al.
(författare)
-
Physical and Chemical Properties of Cloud Droplet Residuals and Aerosol Particles During the Arctic Ocean 2018 Expedition
- 2022
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Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 127:11
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Tidskriftsartikel (refereegranskat)abstract
- Detailed knowledge of the physical and chemical properties and sources of particles that form clouds is especially important in pristine areas like the Arctic, where particle concentrations are often low and observations are sparse. Here, we present in situ cloud and aerosol measurements from the central Arctic Ocean in August–September 2018 combined with air parcel source analysis. We provide direct experimental evidence that Aitken mode particles (particles with diameters ≲70 nm) significantly contribute to cloud condensation nuclei (CCN) or cloud droplet residuals, especially after the freeze-up of the sea ice in the transition toward fall. These Aitken mode particles were associated with air that spent more time over the pack ice, while size distributions dominated by accumulation mode particles (particles with diameters ≳70 nm) showed a stronger contribution of oceanic air and slightly different source regions. This was accompanied by changes in the average chemical composition of the accumulation mode aerosol with an increased relative contribution of organic material toward fall. Addition of aerosol mass due to aqueous-phase chemistry during in-cloud processing was probably small over the pack ice given the fact that we observed very similar particle size distributions in both the whole-air and cloud droplet residual data. These aerosol–cloud interaction observations provide valuable insight into the origin and physical and chemical properties of CCN over the pristine central Arctic Ocean.
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| 26. |
- Kaufman, Darrell, et al.
(författare)
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A global database of Holocene paleotemperature records
- 2020
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- A comprehensive database of paleoclimate records is needed to place recent warming into the longer-term context of natural climate variability. We present a global compilation of quality-controlled, published, temperature-sensitive proxy records extending back 12,000 years through the Holocene. Data were compiled from 679 sites where time series cover at least 4000 years, are resolved at sub-millennial scale (median spacing of 400 years or finer) and have at least one age control point every 3000 years, with cut-off values slackened in data-sparse regions. The data derive from lake sediment (51%), marine sediment (31%), peat (11%), glacier ice (3%), and other natural archives. The database contains 1319 records, including 157 from the Southern Hemisphere. The multi-proxy database comprises paleotemperature time series based on ecological assemblages, as well as biophysical and geochemical indicators that reflect mean annual or seasonal temperatures, as encoded in the database. This database can be used to reconstruct the spatiotemporal evolution of Holocene temperature at global to regional scales, and is publicly available in Linked Paleo Data (LiPD) format.
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| 27. |
- Manzoni, Claudia, et al.
(författare)
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Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
- 2024
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Ingår i: American Journal of Human Genetics. - 0002-9297. ; 111:7, s. 1316-1329
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Tidskriftsartikel (refereegranskat)abstract
- Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 × 10−12, OR = 1.27) and APOE (rs6857; p = 1.31 × 10−12, OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 × 10−8, OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex.
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| 28. |
- McCusker, Gillian Young, et al.
(författare)
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Evaluating Arctic clouds modelled with the Unified Model and Integrated Forecasting System
- 2023
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Ingår i: Atmospheric Chemistry And Physics. - 1680-7316 .- 1680-7324. ; 23:8, s. 4819-4847
-
Tidskriftsartikel (refereegranskat)abstract
- By synthesising remote-sensing measurements made in the central Arctic into a model-gridded Cloudnet cloud product, we evaluate how well the Met Office Unified Model (UM) and the European Centre for Medium-Range Weather Forecasting (ECMWF) Integrated Forecasting System (IFS) capture Arctic clouds and their associated interactions with the surface energy balance and the thermodynamic structure of the lower troposphere. This evaluation was conducted using a 4-week observation period from the Arctic Ocean 2018 expedition, where the transition from sea ice melting to freezing conditions was measured. Three different cloud schemes were tested within a nested limited-area model (LAM) configuration of the UM – two regionally operational single-moment schemes (UM_RA2M and UM_RA2T) and one novel double-moment scheme (UM_CASIM-100) – while one global simulation was conducted with the IFS, utilising its default cloud scheme (ECMWF_IFS).Consistent weaknesses were identified across both models, with both the UM and IFS overestimating cloud occurrence below 3 km. This overestimation was also consistent across the three cloud configurations used within the UM framework, with >90 % mean cloud occurrence simulated between 0.15 and 1 km in all the model simulations. However, the cloud microphysical structure, on average, was modelled reasonably well in each simulation, with the cloud liquid water content (LWC) and ice water content (IWC) comparing well with observations over much of the vertical profile. The key microphysical discrepancy between the models and observations was in the LWC between 1 and 3 km, where most simulations (all except UM_RA2T) overestimated the observed LWC.Despite this reasonable performance in cloud physical structure, both models failed to adequately capture cloud-free episodes: this consistency in cloud cover likely contributes to the ever-present near-surface temperature bias in every simulation. Both models also consistently exhibited temperature and moisture biases below 3 km, with particularly strong cold biases coinciding with the overabundant modelled cloud layers. These biases are likely due to too much cloud-top radiative cooling from these persistent modelled cloud layers and were consistent across the three UM configurations tested, despite differences in their parameterisations of cloud on a sub-grid scale. Alarmingly, our findings suggest that these biases in the regional model were inherited from the global model, driving a cause–effect relationship between the excessive low-altitude cloudiness and the coincident cold bias. Using representative cloud condensation nuclei concentrations in our double-moment UM configuration while improving cloud microphysical structure does little to alleviate these biases; therefore, no matter how comprehensive we make the cloud physics in the nested LAM configuration used here, its cloud and thermodynamic structure will continue to be overwhelmingly biased by the meteorological conditions of its driving model.
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| 29. |
- Penzenstadler, Birgit, 1981, et al.
(författare)
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Vision Paper: The Sustainability Awareness Framework (SusAF) as a De-Facto Standard?
- 2023
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Ingår i: CEUR Workshop Proceedings. - 1613-0073. ; 3378
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Konferensbidrag (refereegranskat)abstract
- For many practitioners, considering sustainability during a software development project is a challenge. The Sustainability Awareness Framework (SusAF) is a tool for thinking through short, medium- and long-term impacts of socio-technical systems on its surrounding environment. While SusAF has been used by several companies, is not widely adopted in industry yet. In this Vision Paper, we discuss the options for extending the reach of SusAF and what it would take to evolve SusAF into a (de-facto) standard.
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| 30. |
- Porter, Grace C.E., et al.
(författare)
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Highly Active Ice-Nucleating Particles at the Summer North Pole
- 2022
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Ingår i: Journal of Geophysical Research: Atmospheres. - 2169-8996 .- 2169-897X. ; 127:6
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Tidskriftsartikel (refereegranskat)abstract
- The amount of ice versus supercooled water in clouds is important for their radiative properties and role in climate feedbacks. Hence, knowledge of the concentration of ice-nucleating particles (INPs) is needed. Generally, the concentrations of INPs are found to be very low in remote marine locations allowing cloud water to persist in a supercooled state. We had expected the concentrations of INPs at the North Pole to be very low given the distance from open ocean and terrestrial sources coupled with effective wet scavenging processes. Here we show that during summer 2018 (August and September) high concentrations of biological INPs (active at >−20°C) were sporadically present at the North Pole. In fact, INP concentrations were sometimes as high as those recorded at mid-latitude locations strongly impacted by highly active biological INPs, in strong contrast to the Southern Ocean. Furthermore, using a balloon borne sampler we demonstrated that INP concentrations were often different at the surface versus higher in the boundary layer where clouds form. Back trajectory analysis suggests strong sources of INPs near the Russian coast, possibly associated with wind-driven sea spray production, whereas the pack ice, open leads, and the marginal ice zone were not sources of highly active INPs. These findings suggest that primary ice production, and therefore Arctic climate, is sensitive to transport from locations such as the Russian coast that are already experiencing marked climate change.
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| 31. |
- Price, Ruth, et al.
(författare)
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Late summer transition from a free-tropospheric to boundary layer source of Aitken mode aerosol in the high Arctic
- 2023
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 23:5, s. 2927-2961
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Tidskriftsartikel (refereegranskat)abstract
- In the Arctic, the aerosol budget plays a particular role in determining the behaviour of clouds, which are important for the surface energy balance and thus for the region's climate. A key question is the extent to which cloud condensation nuclei in the high Arctic summertime boundary layer are controlled by local emission and formation processes as opposed to transport from outside. Each of these sources is likely to respond differently to future changes in ice cover. Here we use a global model and observations from ship and aircraft field campaigns to understand the source of high Arctic aerosol in late summer. We find that particles formed remotely, i.e. at latitudes outside the Arctic, are the dominant source of boundary layer Aitken mode particles during the sea ice melt period up to the end of August. Particles from such remote sources, entrained into the boundary layer from the free troposphere, account for nucleation and Aitken mode particle concentrations that are otherwise underestimated by the model. This source from outside the high Arctic declines as photochemical rates decrease towards the end of summer and is largely replaced by local new particle formation driven by iodic acid created during freeze-up. Such a local source increases the simulated Aitken mode particle concentrations by 2 orders of magnitude during sea ice freeze-up and is consistent with strong fluctuations in nucleation mode concentrations that occur in September. Our results suggest a high-Arctic aerosol regime shift in late summer, and only after this shift do cloud condensation nuclei become sensitive to local aerosol processes.
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| 32. |
- Prytherch, John, et al.
(författare)
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Air-sea CO2 and CH4 gas transfer velocity in Arctic sea-ice regions from eddy covariance flux measurements onboard Icebreaker Oden
- 2017
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Ingår i: Geophysical Research Abstracts. - 1029-7006 .- 1607-7962. ; 19
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Tidskriftsartikel (refereegranskat)abstract
- The Arctic Ocean is an important sink for atmospheric CO2, and there is ongoing debate on whether seafloor seeps in the Arctic are a large source of CH4 to the atmosphere. The impact of warming waters, decreasing sea-ice extent and expanding marginal ice zones on Arctic air-sea gas exchange depends on the rate of gas transfer in the presence of sea ice. Sea ice acts as a near-impermeable lid to air-sea gas exchange, but is also hypothesised to enhance gas transfer rates through physical processes such as increased surface-ocean turbulence from ice-water shear and ice-edge form drag. The dependence of the gas transfer rate on sea-ice concentration remains uncertain due to a lack of in situ measurements. Here we present the first direct estimates of gas transfer rate in a wide range of Arctic sea-ice conditions. The estimates were derived from eddy covariance CO2 and CH4 fluxes, measured from the Swedish Icebreaker Oden during two expeditions: the 3-month duration Arctic Clouds in Summer Experiment (ACSE) in 2014, a component of the Swedish-Russian-US Arctic Ocean Investigation on Climate-Cryosphere-Carbon Interactions (SWERUS-C3) in the eastern Arctic Ocean shelf region; and the Arctic Ocean 2016 expedition to the high latitude Arctic Ocean. Initial CO2 results from ACSE showed that the gas transfer rate has a near-linear dependence on sea-ice concentration, and that some previous indirect measurements and modelling estimates overestimate gas transfer rates in sea-ice regions. This supports a linear sea-ice scaling approach for assessments of polar ocean carbon fluxes. Air-sea gas transfer model assumptions (e.g. Schmidt number dependence) will be examined using simultaneous CO2 and CH4 measurements, and observations in different ice conditions (e.g. summer melt, autumn freeze up, central Arctic and marginal ice zones) will be compared.
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| 33. |
- Prytherch, John, et al.
(författare)
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Direct determination of the air-sea CO2 gas transfer velocity in Arctic sea ice regions
- 2017
-
Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 44:8, s. 3770-3778
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Tidskriftsartikel (refereegranskat)abstract
- The Arctic Ocean is an important sink for atmospheric CO2. The impact of decreasing sea ice extent and expanding marginal ice zones on Arctic air-sea CO2 exchange depends on the rate of gas transfer in the presence of sea ice. Sea ice acts to limit air-sea gas exchange by reducing contact between air and water but is also hypothesized to enhance gas transfer rates across surrounding open-water surfaces through physical processes such as increased surface-ocean turbulence from ice-water shear and ice-edge form drag. Here we present the first direct determination of the CO2 air-sea gas transfer velocity in a wide range of Arctic sea ice conditions. We show that the gas transfer velocity increases near linearly with decreasing sea ice concentration. We also show that previous modeling approaches overestimate gas transfer rates in sea ice regions.
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| 34. |
- Rogers, David, et al.
(författare)
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Highlights of Coastal Waves 1996
- 1998
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 79, s. 1307-1326
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Tidskriftsartikel (refereegranskat)
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| 35. |
- Rosenberg, Philip D., et al.
(författare)
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Quantifying particle size and turbulent scale dependence of dust flux in the Sahara using aircraft measurements
- 2014
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Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 119:12, s. 7577-7598
-
Tidskriftsartikel (refereegranskat)abstract
- The first size-resolved airborne measurements of dust fluxes and the first dust flux measurements from the central Sahara are presented and compared with a parameterization by Kok (2011a). High-frequency measurements of dust size distribution were obtained from 0.16 to 300 mu m diameter, and eddy covariance fluxes were derived. This is more than an order of magnitude larger size range than previous flux estimates. Links to surface emission are provided by analysis of particle drift velocities. Number flux is described by a -2 power law between 1 and 144 mu m diameter, significantly larger than the 12 mu m upper limit suggested by Kok (2011a). For small particles, the deviation from a power law varies with terrain type and the large size cutoff is correlated with atmospheric vertical turbulent kinetic energy, suggesting control by vertical transport rather than emission processes. The measured mass flux mode is in the range 30-100 mu m. The turbulent scales important for dust flux are from 0.1 km to 1-10 km. The upper scale increases during the morning as boundary layer depth and eddy size increase. All locations where large dust fluxes were measured had large topographical variations. These features are often linked with highly erodible surface features, such as wadis or dunes. We also hypothesize that upslope flow and flow separation over such features enhance the dust flux by transporting large particles out of the saltation layer. The tendency to locate surface flux measurements in open, flat terrain means these favored dust sources have been neglected in previous studies.
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| 36. |
- Sotiropoulou, Georgia, et al.
(författare)
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The thermodynamic structure of summer Arctic stratocumulus and the dynamic coupling to the surface
- 2014
-
Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 14:22, s. 12573-12592
-
Tidskriftsartikel (refereegranskat)abstract
- The vertical structure of Arctic low-level clouds and Arctic boundary layer is studied, using observations from ASCOS (Arctic Summer Cloud Ocean Study), in the central Arctic, in late summer 2008. Two general types of cloud structures are examined: the "neutrally stratified" and "stably stratified" clouds. Neutrally stratified are mixed-phase clouds where radiative-cooling near cloud top produces turbulence that generates a cloud-driven mixed layer. When this layer mixes with the surface-generated turbulence, the cloud layer is coupled to the surface, whereas when such an interaction does not occur, it remains decoupled; the latter state is most frequently observed. The decoupled clouds are usually higher compared to the coupled; differences in thickness or cloud water properties between the two cases are however not found. The surface fluxes are also very similar for both states. The decoupled clouds exhibit a bimodal thermodynamic structure, depending on the depth of the sub-cloud mixed layer (SCML): clouds with shallower SCMLs are disconnected from the surface by weak inversions, whereas those that lay over a deeper SCML are associated with stronger inversions at the decoupling height. Neutrally stratified clouds generally precipitate; the evaporation/sublimation of precipitation often enhances the decoupling state. Finally, stably stratified clouds are usually lower, geometrically and optically thinner, non-precipitating liquid-water clouds, not containing enough liquid to drive efficient mixing through cloud-top cooling.
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| 37. |
- Tjernström, Michael, et al.
(författare)
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Arctic Summer Airmass Transformation, Surface Inversions, and the Surface Energy Budget
- 2019
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Ingår i: Journal of Climate. - 0894-8755 .- 1520-0442. ; 32:3, s. 769-789
-
Tidskriftsartikel (refereegranskat)abstract
- During the Arctic Clouds in Summer Experiment (ACSE) in summer 2014 a weeklong period of warm-air advection over melting sea ice, with the formation of a strong surface temperature inversion and dense fog, was observed. Based on an analysis of the surface energy budget, we formulated the hypothesis that, because of the airmass transformation, additional surface heating occurs during warm-air intrusions in a zone near the ice edge. To test this hypothesis, we explore all cases with surface inversions occurring during ACSE and then characterize the inversions in detail. We find that they always occur with advection from the south and are associated with subsidence. Analyzing only inversion cases over sea ice, we find two categories: one with increasing moisture in the inversion and one with constant or decreasing moisture with height. During surface inversions with increasing moisture with height, an extra 10-25 W m(-2) of surface heating was observed, compared to cases without surface inversions; the surface turbulent heat flux was the largest single term. Cases with less moisture in the inversion were often cloud free and the extra solar radiation plus the turbulent surface heat flux caused by the inversion was roughly balanced by the loss of net longwave radiation.
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| 38. |
- Vandenberghe, Rik, et al.
(författare)
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F-18-Flutemetamol Amyloid Imaging in Alzheimer Disease and Mild Cognitive Impairment A Phase 2 Trial
- 2010
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Ingår i: Annals of Neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 68:3, s. 319-329
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The most widely studied positron emission tomography ligand for in vivo P-amyloid imaging is C-11-Pittsburgh compound B (C-11-PIB). Its availability, however, is limited by the need for an on-site cyclotron. Validation of the F-18-labeled PIB derivative F-18-flutemetamol could significantly enhance access to this novel technology. Methods: Twenty-seven patients with early-stage clinically probable Alzheimer disease (AD), 20 with amnestic mild cognitive impairment (MCI), and 15 cognitively intact healthy volunteers (HVs) above and 10 HVs below 55 years of age participated. The primary endpoint was the efficacy of blinded visual assessments of F-18-flutemetamol scans in assigning subjects to a raised versus normal uptake category, with clinical diagnosis as the standard of truth (SOT). As secondary objectives, we determined the correlation between the regional standardized uptake value ratios (SUVRs) for F-18-flutemetamol and its parent molecule C-11-PIB in 20 of the AD subjects and 20 of the MCI patients. We also determined test-retest variability of F-18-flutemetamol SUVRs in 5 of the AD subjects. Results: Blinded visual assessments of F-18-flutemetamol scans assigned 25 of 27 scans from AD subjects and 1 of 15 scans from the elderly HVs to the raised category, corresponding to a sensitivity of 93.1% and a specificity of 93.3% against the SOT. Correlation coefficients between cortical F-18-flutemetamol SUVRs and C-11-PIB SUVRs ranged from 0.89 to 0.92. Test-retest variabilities of regional SUVRs were 1 to 4%. Interpretation: F-18-Flutemetamol performs similarly to the C-11-PIB parent molecule within the same subjects and provides high test-retest replicability and potentially much wider accessibility for clinical and research use. ANN NEUROL 2010;68:319-329
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| 39. |
- Venters, Colin C., et al.
(författare)
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Software Sustainability: Beyond the Tower of Babel
- 2021
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Ingår i: Proceedings - 2021 IEEE/ACM International Workshop on Body of Knowledge for Software Sustainability, BoKSS 2021. ; , s. 3-4
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Konferensbidrag (refereegranskat)
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| 40. |
- Venters, Colin C., et al.
(författare)
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Sustainable software engineering: Reflections on advances in research and practice
- 2023
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Ingår i: Information and Software Technology. - 0950-5849. ; 164
-
Tidskriftsartikel (refereegranskat)abstract
- Context: Modern societies are highly dependent on complex, large-scale, software-intensive systems that increasingly operate within an environment of continuous availability, which are challenging to maintain, and evolve in response to changes in stakeholder requirements of the system. Software architectures are the foundation of any software system and provide a mechanism for reasoning about core software quality requirements. Their sustainability – the capacity to endure in changing environments – is a critical concern for software architecture research and practice. Objective: The objective of the paper is to re-examine our previous assumptions and arguments in light of advances in the field. This reflection paper provides an opportunity to obtain new insights into the trends in software sustainability in both academia and industry, from a software architecture perspective specifically and software engineering more broadly. Given advances in research in the field, the increasing introduction of academic courses on different sustainability topics, and the engagement of companies to cope with sustainability goals, we reflect on advances and maturity about the role sustainability in general plays in today's society. More specifically, we revisit the trends, open issues and research challenges identified five years ago in our previous paper on software sustainability research and practice from a software architecture viewpoint, which aimed to provide a foundation and roadmap of emerging research themes in the area of sustainable software architectures in order to consider how this paper influenced and motivated research in the intervening years. Method: The forward snowballing method was used to establish the methodological basis for our reflection on the state of the art. A total of 234 studies were identified between April 2018 and June 2023 and 102 studies were found to be relevant according to the selection criteria. A further subset was mapped to the primary themes of the original paper including definitions and concepts, reference architectures, measures and metrics, and education. Vision: The vision of this reflection paper is to provide a new foundation and road map of emerging research themes in the area of sustainable software engineering highlighting recent trends, and open issues and research challenges.
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| 41. |
- Venters, Colin C., et al.
(författare)
-
Sustainable software engineering: Reflections on advances in research and practice
- 2023
-
Ingår i: Information and Software Technology. - 0950-5849. ; 164
-
Tidskriftsartikel (refereegranskat)abstract
- Context: Modern societies are highly dependent on complex, large-scale, software-intensive systems that increasingly operate within an environment of continuous availability, which are challenging to maintain, and evolve in response to changes in stakeholder requirements of the system. Software architectures are the foundation of any software system and provide a mechanism for reasoning about core software quality requirements. Their sustainability – the capacity to endure in changing environments – is a critical concern for software architecture research and practice. Objective: The objective of the paper is to re-examine our previous assumptions and arguments in light of advances in the field. This reflection paper provides an opportunity to obtain new insights into the trends in software sustainability in both academia and industry, from a software architecture perspective specifically and software engineering more broadly. Given advances in research in the field, the increasing introduction of academic courses on different sustainability topics, and the engagement of companies to cope with sustainability goals, we reflect on advances and maturity about the role sustainability in general plays in today's society. More specifically, we revisit the trends, open issues and research challenges identified five years ago in our previous paper on software sustainability research and practice from a software architecture viewpoint, which aimed to provide a foundation and roadmap of emerging research themes in the area of sustainable software architectures in order to consider how this paper influenced and motivated research in the intervening years. Method: The forward snowballing method was used to establish the methodological basis for our reflection on the state of the art. A total of 234 studies were identified between April 2018 and June 2023 and 102 studies were found to be relevant according to the selection criteria. A further subset was mapped to the primary themes of the original paper including definitions and concepts, reference architectures, measures and metrics, and education. Vision: The vision of this reflection paper is to provide a new foundation and road map of emerging research themes in the area of sustainable software engineering highlighting recent trends, and open issues and research challenges.
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| 42. |
- Vos, Theo, et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
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Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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| 43. |
- Vüllers, Jutta, et al.
(författare)
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Meteorological and cloud conditions during the Arctic Ocean 2018 expedition
- 2021
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 21:1, s. 289-314
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Tidskriftsartikel (refereegranskat)abstract
- The Arctic Ocean 2018 (AO2018) took place in the central Arctic Ocean in August and September 2018 on the Swedish icebreaker Oden. An extensive suite of instrumentation provided detailed measurements of surface water chemistry and biology, sea ice and ocean physical and biogeochemical properties, surface exchange processes, aerosols, clouds, and the state of the atmosphere. The measurements provide important information on the coupling of the ocean and ice surface to the atmosphere and in particular to clouds. This paper provides (i) an overview of the synoptic-scale atmospheric conditions and their climatological anomaly to help interpret the process studies and put the detailed observations from AO2018 into a larger context, both spatially and temporally; (ii) a statistical analysis of the thermodynamic and near-surface meteorological conditions, boundary layer, cloud, and fog characteristics; and (iii) a comparison of the results to observations from earlier Arctic Ocean expeditions – in particular AOE1996 (Arctic Ocean Expedition 1996), SHEBA (Surface Heat Budget of the Arctic Ocean), AOE2001 (Arctic Ocean Experiment 2001), ASCOS (Arctic Summer Cloud Ocean Study), ACSE (Arctic Clouds in Summer Experiment), and AO2016 (Arctic Ocean 2016) – to provide an assessment of the representativeness of the measurements. The results show that near-surface conditions were broadly comparable to earlier experiments; however the thermodynamic vertical structure was quite different. An unusually high frequency of well-mixed boundary layers up to about 1 km depth occurred, and only a few cases of the “prototypical” Arctic summer single-layer stratocumulus deck were observed. Instead, an unexpectedly high amount of multiple cloud layers and mid-level clouds were present throughout the campaign. These differences from previous studies are related to the high frequency of cyclonic activity in the central Arctic in 2018.
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- Zinke, Julika, et al.
(författare)
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The development of a miniaturised balloon-borne cloud water sampler and its first deployment in the high Arctic
- 2021
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Ingår i: Tellus. Series B, Chemical and physical meteorology. - : Stockholm University Press. - 0280-6509 .- 1600-0889. ; 73:1, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- The chemical composition of cloud water can be used to infer the sources of particles upon which cloud droplets and ice crystals have formed. In order to obtain cloud water for analysis of chemical composition for elevated clouds in the pristine high Arctic, balloon-borne active cloud water sampling systems are the optimal approach. However, such systems have not been feasible to deploy previously due to their weight and the challenging environmental conditions. We have taken advantage of recent developments in battery technology to develop a miniaturised cloud water sampler for balloon-borne collection of cloud water. Our sampler is a bulk sampler with a cloud drop cutoff diameter of approximately 8 mu m and an estimated collection efficiency of 70%. The sampler was heated to prevent excessive ice accumulation and was able to operate for several hours under the extreme conditions encountered in the high Arctic. We have tested and deployed the new sampler on a tethered balloon during the Microbiology-Ocean-Cloud-Coupling in the High Arctic (MOCCHA) campaign in August and September 2018 close to the North pole. The sampler was able to successfully retrieve cloud water samples that were analysed to determine their chemical composition as well as their ice-nucleating activity. Given the pristine conditions found in the high Arctic we have placed significant emphasis on the development of a suitable cleaning procedure to minimise background contamination by the sampler itself.
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