| 1. |
- Pulit, S. L., et al.
(author)
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
- 2018
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In: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
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Journal article (peer-reviewed)abstract
- Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
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| 2. |
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| 3. |
- Marini, S., et al.
(author)
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Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity A Meta-analysis
- 2019
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In: Jama Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:4, s. 480-491
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Journal article (peer-reviewed)abstract
- IMPORTANCE Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. OBJECTIVE To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) epsilon 4 alleles, the most potent genetic risk factor for ICH. DESIGN, SETTING, AND PARTICIPANTS This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. MAIN OUTCOMES AND MEASURES Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. RESULTS In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE epsilon 2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P < .001) and APOE epsilon 4 (OR, 1.51; 95% CI, 1.23-1.85; P < .001) were associated with lobar ICH risk; however, within self-identified Hispanic and black participants, no associations were found. After propensity score matching for hypertension burden, APOE epsilon 4 was associated with lobar ICH risk among Hispanic (OR, 1.14; 95% CI, 1.03-1.28; P = .01) but not in black (OR, 1.02; 95% CI, 0.98-1.07; P = .25) participants. APOE epsilon 2 and epsilon 4 did not show an association with nonlobar ICH risk in any race/ethnicity. CONCLUSIONS AND RELEVANCE APOE epsilon 4 and epsilon 2 alleles appear to affect lobar ICH risk variably by race/ethnicity, associations that are confirmed in white individuals but can be shown in Hispanic individuals only when the excess burden of hypertension is propensity score-matched; further studies are needed to explore the interactions between APOE alleles and environmental exposures that vary by race/ethnicity in representative populations at risk for ICH.
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| 4. |
- Creevey, O. L., et al.
(author)
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Gaia Data Release 3 : Astrophysical parameters inference system (Apsis). I. Methods and content overview
- 2023
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 674
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Journal article (peer-reviewed)abstract
- Gaia Data Release 3 contains a wealth of new data products for the community. Astrophysical parameters are a major component of this release, and were produced by the Astrophysical parameters inference system (Apsis) within the Gaia Data Processing and Analysis Consortium (DPAC). The aim of this paper is to describe the overall content of the astrophysical parameters in Gaia DR3 and how they were produced. In Apsis, we use the mean BP /RP and mean RVS spectra along with astrometry and photometry, and we derive the following parameters: source classification and probabilities for 1.6 billion objects; interstellar medium characterisation and distances for up to 470 million sources, including a 2D total Galactic extinction map; 6 million redshifts of quasar candidates; 1.4 million redshifts of galaxy candidates; and an analysis of 50 million outlier sources through an unsupervised classification. The astrophysical parameters also include many stellar spectroscopic and evolutionary parameters for up to 470 million sources. These comprise T-eff, log g, and [M /H] (470 million using BP /RP, 6 million using RVS), radius (470 million), mass (140 million), age (120 million), chemical abundances (up to 5 million), diffuse interstellar band analysis (0.5 million), activity indices (2 million), H ff equivalent widths (200 million), and further classification of spectral types (220 million) and emission-line stars (50 000). This paper is the first in a series of three papers, and focusses on describing the global content of the parameters in Gaia DR3. The accompanying Papers II and III focus on the validation and use of the stellar and non-stellar products, respectively. This catalogue is the most extensive homogeneous database of astrophysical parameters to date, and is based uniquely on Gaia data. It will only be superseded by Gaia Data Release 4, and will therefore remain a key reference over the next four years, providing astrophysical parameters independent of other ground- and space-based data.
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| 6. |
- Hacke, W, et al.
(author)
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Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials
- 2018
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In: International journal of stroke : official journal of the International Stroke Society. - : SAGE Publications. - 1747-4949. ; 13:2, s. 175-189
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Journal article (peer-reviewed)abstract
- The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke differs between the Europe Union and United States. Aims We compared the effects of alteplase in cohorts defined by the current Europe Union or United States marketing approval labels, and by hypothetical revisions of the labels that would remove the Europe Union upper age limit or extend the United States treatment time window to 4.5 h. Methods We assessed outcomes in an individual-patient-data meta-analysis of eight randomized trials of intravenous alteplase (0.9 mg/kg) versus control for acute ischemic stroke. Outcomes included: excellent outcome (modified Rankin score 0–1) at 3–6 months, the distribution of modified Rankin score, symptomatic intracerebral hemorrhage, and 90-day mortality. Results Alteplase increased the odds of modified Rankin score 0–1 among 2449/6136 (40%) patients who met the current European Union label and 3491 (57%) patients who met the age-revised label (odds ratio 1.42, 95% CI 1.21−1.68 and 1.43, 1.23−1.65, respectively), but not in those outside the age-revised label (1.06, 0.90−1.26). By 90 days, there was no increased mortality in the current and age-revised cohorts (hazard ratios 0.98, 95% CI 0.76−1.25 and 1.01, 0.86–1.19, respectively) but mortality remained higher outside the age-revised label (1.19, 0.99–1.42). Similarly, alteplase increased the odds of modified Rankin score 0-1 among 1174/6136 (19%) patients who met the current US approval and 3326 (54%) who met a 4.5-h revised approval (odds ratio 1.55, 1.19−2.01 and 1.37, 1.17−1.59, respectively), but not for those outside the 4.5-h revised approval (1.14, 0.97−1.34). By 90 days, no increased mortality remained for the current and 4.5-h revised label cohorts (hazard ratios 0.99, 0.77−1.26 and 1.02, 0.87–1.20, respectively) but mortality remained higher outside the 4.5-h revised approval (1.17, 0.98–1.41). Conclusions An age-revised European Union label or 4.5-h-revised United States label would each increase the number of patients deriving net benefit from alteplase by 90 days after acute ischemic stroke, without excess mortality.
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| 7. |
- Kucinskas, Arunas, et al.
(author)
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Broad-band photometric colors and effective temperature calibrations for late-type giants - I. Z=0.02
- 2005
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In: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 442:1, s. 281-308
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Journal article (peer-reviewed)abstract
- We present new synthetic broad-band photometric colors for late-type giants based on synthetic spectra calculated with the PHOENIX model atmosphere code. The grid covers effective temperatures T-eff = 3000... 5000 K, gravities log g = - 0.5... + 3.5, and metallicities [M/H] = + 0.5... - 4.0. We show that individual broad-band photometric colors are strongly affected by model parameters such as molecular opacities, gravity, microturbulent velocity, and stellar mass. Our exploratory 3D modeling of a prototypical late-type giant shows that convection has a noticeable effect on the photometric colors too, as it alters significantly both the vertical and horizontal thermal structures in the outer atmosphere. The differences between colors calculated with full 3D hydrodynamical and 1D model atmospheres are significant (e.g.,. (V- K) similar to 0.2 mag), translating into offsets in effective temperature of up to similar to 70 K. For a sample of 74 late-type giants in the Solar neighborhood, with interferometric effective temperatures and broad-band photometry available in the literature, we compare observed colors with a new PHOENIX grid of synthetic photometric colors, as well as with photometric colors calculated with the MARCS and ATLAS model atmosphere codes. We find good agreement of the new synthetic colors with observations and published T-eff-color and color - color relations, especially in the T-eff ( V - K), T-eff-(J - K) and (J - K) -(V - K) planes. Deviations from the observed trends in the T-eff-color planes are generally within +/- 100 K for T-eff = 3500 to 4800 K. Synthetic colors calculated with different stellar atmosphere models agree to +/- 100 K, within a large range of effective temperatures and gravities. The comparison of the observed and synthetic spectra of late-type giants shows that discrepancies result from the differences both in the strengths of various spectral lines/bands ( especially those of molecular bands, such as TiO, H2O, CO) and the continuum level. Finally, we derive several new T-eff - log g - color relations for late-type giants at solar-metallicity (valid for T-eff = 3500 to 4800 K), based both on the observed effective temperatures and colors of the nearby giants, and synthetic colors produced with PHOENIX, MARCS and ATLAS model atmospheres.
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| 8. |
- Kucinskas, Arunas, et al.
(author)
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Broad-band photometric colors and effective temperature calibrations for late-type giants - II. Z <0.02
- 2006
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In: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 452:3, s. 1021-1038
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Journal article (peer-reviewed)abstract
- We investigate the effects of metallicity on the broad-band photometric colors of late-type giants, and make a comparison of synthetic colors with observed photometric properties of late-type giants over a wide range of effective temperatures (T-eff = 3500- 4800K) and gravities (log g = 0.0-2.5), at [M/H] = -1.0 and -2.0. The influence of metallicity on the synthetic photometric colors is small at effective temperatures above similar to 3800K, but the effects grow larger at lower T-eff,T- due to the changing effciency of molecule formation which reduces molecular opacities at lower [M/H]. To make a detailed comparison of the synthetic and observed photometric colors of late type giants in the T-eff-color and color-color planes (which is done at two metallicities, [M/H] = -1.0 and -2.0), we derive a set of new T-eff-log g-color relations based on synthetic photometric colors, at [M/H] = -0.5, -1.0, -1.5, and -2.0. These relations are based on the T-eff- log g scales that we derive employing literature data for 178 late-type giants in 10 Galactic globular clusters (with metallicities of the individual stars between [M/H] = -0.7 and -2.5), and synthetic colors produced with the PHOENIX, MARCS and ATLAS stellar atmosphere codes. Combined with the T-eff- log g-color relations at [M/H] = 0.0 (Kucinskas et al. 2005), the set of new relations covers metallicities [M/H] = 0.0... -2.0 ([M/H] = 0.5), effective temperatures T-eff = 3500... 4800 K (T-eff = 100K), and gravities log g = - 0.5... 3.0. The new T-eff- log g-color relations are in good agreement with published T-eff-color relations based on observed properties of late-type giants, both at [M/H] = -1.0 and -2.0. The differences in all T-eff- color planes are typically well within similar to 100K. We find, however, that effective temperatures predicted by the scales based on synthetic colors tend to be slightly higher than those resulting from the T-eff- color relations based on observations, with the offsets up to similar to 100 K. This is clearly seen both at [M/H] = -1.0 and -2.0, especially in the T-eff-(B - V) and T-eff-(V - K) planes. The consistency between T-eff- log g-color scales based on synthetic colors calculated with different stellar atmosphere codes is very good, with typical differences being well within. Delta T-eff similar to 70 K at [M/H] = - 1.0 and. T-eff similar to 40 K at [M/H] = -2.0.
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| 9. |
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| 10. |
- Vallenari, A., et al.
(author)
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Synthetic stellar libraries and SSP simulations in the Gaia Era
- 2009
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In: Proceedings of the International Astronomical Union. ; , s. 444-445
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Conference paper (peer-reviewed)abstract
- The Gaia mission will obtain accurate positions, parallaxes and proper motions for 109 object all over the sky. In addition, it will collect low resolution spectroscopy in the optical range for ∼ 109 objects, stars, galaxies, and QSOs. Parameters of those objects are expected to be part of the final Catalog. Complete and up-to-date libraries of synthetic stellar spectra are needed to train the algorithms to classify this huge amount of data. Here we focus on the use of the synthetic libraries of spectra calculated by the Gaia community to derive grids of Single Stellar Populations as building blocks of population synthesis models. © International Astronomical Union 2010.
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