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- Morgado, B. E., et al.
(författare)
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A stellar occultation by the transneptunian object (50000) Quaoar observed by CHEOPS
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 664
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Tidskriftsartikel (refereegranskat)abstract
- Context. Stellar occultation is a powerful technique that allows the determination of some physical parameters of the occulting object. The result depends on the photometric accuracy, the temporal resolution, and the number of chords obtained. Space telescopes can achieve high photometric accuracy as they are not affected by atmospheric scintillation. Aims. Using ESA's CHEOPS space telescope, we observed a stellar occultation by the transneptunian object (50000) Quaoar. We compare the obtained chord with previous occultations by this object and determine its astrometry with sub-milliarcsecond precision. Also, we determine upper limits to the presence of a global methane atmosphere on the occulting body. Methods. We predicted and observed a stellar occultation by Quaoar using the CHEOPS space telescope. We measured the occultation light curve from this dataset and determined the dis- and reappearance of the star behind the occulting body. Furthermore, a ground-based telescope in Australia was used to constrain Quaoar's limb. Combined with results from previous works, these measurements allowed us to obtain a precise position of Quaoar at the occultation time. Results. We present the results obtained from the first stellar occultation by a transneptunian object using a space telescope orbiting Earth; it was the occultation by Quaoar observed on 2020 June 11. We used the CHEOPS light curve to obtain a surface pressure upper limit of 85 nbar for the detection of a global methane atmosphere. Also, combining this observation with a ground-based observation, we fitted Quaoar's limb to determine its astrometric position with an uncertainty below 1.0 mas. Conclusions. This observation is the first of its kind, and it shall be considered as a proof of concept of stellar occultation observations of transneptunian objects with space telescopes orbiting Earth. Moreover, it shows significant prospects for the James Webb Space Telescope.
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- Jayson, G.C., et al.
(författare)
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Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer
- 2005
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 41:4, s. 555-563
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Tidskriftsartikel (refereegranskat)abstract
- We assessed the tolerability, safety, pharmacokinetics and dose-limiting toxicity (DLT) of the recombinant humanized IgG4 anti-vascular endothelial growth factor (VEGF) monoclonal antibody, HuMV833, in patients with advanced cancer. Cohorts of patients with progressive solid tumours received escalating doses of HuMV833 as a 1-h intravenous (I.V.) infusion on days 1, 15, 22, and 29. Twenty patients (median Eastern Cooperative Oncology Group (ECOG) score 1) were accrued. HuMV833 infusions were well tolerated and there were no grade III or IV toxicities definitely related to the antibody. Grade I or II toxicities probably related to the antibody included fatigue, dyspnoea and rash. There were two episodes of asymptomatic hypocalcaemia, one at grade III and one grade IV, which were recorded in early follow-up. There were eight grade I episodes of asymptomatic elevation of activated partial thromboplastin time (APTT) and two grade III events, one in a patient receiving 1 mg/kg and the other receiving extended doses of 10 mg/kg. Pharmacokinetic analysis revealed a non-linear kinetic and an elimination half-life of between 8.2 (0.3 mg/kg) and 18.7 (10 mg/kg) days. One patient with ovarian cancer experienced a partial response (PR) of 9 months duration and eight had disease stabilisation (SD) including one patient with colorectal carcinoma whose disease was stable for 14 months. In 13 of the 14 samples taken from 12 patients, the plasma concentration of hepatocyte growth factor (HGF) was reduced 24 h after drug administration. HuMV833 is safe and lacked DLT at doses up to 10 mg/kg on this schedule. Multiple doses were well tolerated, despite occasional asymptomatic elevations in APTT. By combining pharmacokinetic, pharmacodynamic and toxicity data, we can identify doses of 1 and 3 mg/kg for further investigation. HuMV833 appears to possess some clinical activity. © 2004 Published by Elsevier Ltd.
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- Lee, Sarah C., et al.
(författare)
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Nano-encapsulated Escherichia coli Divisome Anchor ZipA, and in Complex with FtsZ
- 2019
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- The E. coli membrane protein ZipA, binds to the tubulin homologue FtsZ, in the early stage of cell division. We isolated ZipA in a Styrene Maleic Acid lipid particle (SMALP) preserving its position and integrity with native E. coli membrane lipids. Direct binding of ZipA to FtsZ is demonstrated, including FtsZ fibre bundles decorated with ZipA. Using Cryo-Electron Microscopy, small-angle X-ray and neutron scattering, we determine the encapsulated-ZipA structure in isolation, and in complex with FtsZ to a resolution of 1.6 nm. Three regions can be identified from the structure which correspond to, SMALP encapsulated membrane and ZipA transmembrane helix, a separate short compact tether, and ZipA globular head which binds FtsZ. The complex extends 12 nm from the membrane in a compact structure, supported by mesoscale modelling techniques, measuring the movement and stiffness of the regions within ZipA provides molecular scale analysis and visualisation of the early divisome.
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- Broughton, J
(författare)
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A study of causation factors in car accidents
- 1996
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Ingår i: Proceedings of Road safety in Europe. Conference in Birmingham, United Kingdom, September 9-11, 1996. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 179-195
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Hansson, Joacim, 1966-, et al.
(författare)
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Knowledge Organization
- 2005. - 1
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Ingår i: European Curriculum Refliections on Library and Information Science Education. ; , s. 133-148
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Vintr, Tomas, et al.
(författare)
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Time-varying Pedestrian Flow Models for Service Robots
- 2019
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Ingår i: 2019 European Conference on Mobile Robots (ECMR). - : IEEE. - 9781728136059
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Konferensbidrag (refereegranskat)abstract
- We present a human-centric spatio-temporal model for service robots operating in densely populated environments for long time periods. The method integrates observations of pedestrians performed by a mobile robot at different locations and times into a memory efficient model, that represents the spatial layout of natural pedestrian flows and how they change over time. To represent temporal variations of the observed flows, our method does not model the time in a linear fashion, but by several dimensions wrapped into themselves. This representation of time can capture long-term (i.e. days to weeks) periodic patterns of peoples’ routines and habits. Knowledge of these patterns allows making long-term predictions of future human presence and walking directions, which can support mobile robot navigation in human-populated environments. Using datasets gathered by a robot for several weeks, we compare the model to state-of-the-art methods for pedestrian flow modelling.
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