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- Herique, A., et al.
(author)
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Direct observations of asteroid interior and regolith structure : Science measurement requirements
- 2018
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In: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 62:8, s. 2141-2162
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Journal article (peer-reviewed)abstract
- Our knowledge of the internal structure of asteroids is, so far, indirect - relying entirely on inferences from remote sensing observations of the surface, and theoretical modeling of formation and evolution. What are the bulk properties of the regolith and deep interior? And what are the physical processes that shape asteroid internal structures? Is the composition and size distribution observed on the surface representative of the bulk? These questions are crucial to understand small bodies' history from accretion in the early Solar System to the present, and direct measurements are needed to answer these questions for the benefit of science as well as for planetary defense or exploration. Radar is one of the main instruments capable of sounding asteroids to characterize internal structure from sub-meter to global scale. In this paper, we review the science case for direct observation of the deep internal structure and regolith of a rocky asteroid of kilometer size or smaller. We establish the requirements and model dielectric properties of asteroids to outline a possible instrument suite, and highlight the capabilities of radar instrumentation to achieve these observations. We then review the expected science return including secondary objectives contributing to the determination of the gravitational field, the shape model, and the dynamical state. This work is largely inherited from MarcoPolo-R and AIDA/AIM studies.
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- Parsons, Michael T, et al.
(author)
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Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants : An ENIGMA resource to support clinical variant classification
- 2019
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In: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; , s. 1557-1578
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Journal article (peer-reviewed)abstract
- The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared to information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known non-pathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification. This article is protected by copyright. All rights reserved.
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- Fletcher, Leigh N., et al.
(author)
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Jupiter Science Enabled by ESA's Jupiter Icy Moons Explorer
- 2023
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In: Space Science Reviews. - : Springer Nature. - 0038-6308 .- 1572-9672. ; 219:7
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Research review (peer-reviewed)abstract
- ESA's Jupiter Icy Moons Explorer (JUICE) will provide a detailed investigation of the Jovian system in the 2030s, combining a suite of state-of-the-art instruments with an orbital tour tailored to maximise observing opportunities. We review the Jupiter science enabled by the JUICE mission, building on the legacy of discoveries from the Galileo, Cassini, and Juno missions, alongside ground- and space-based observatories. We focus on remote sensing of the climate, meteorology, and chemistry of the atmosphere and auroras from the cloud-forming weather layer, through the upper troposphere, into the stratosphere and ionosphere. The Jupiter orbital tour provides a wealth of opportunities for atmospheric and auroral science: global perspectives with its near-equatorial and inclined phases, sampling all phase angles from dayside to nightside, and investigating phenomena evolving on timescales from minutes to months. The remote sensing payload spans far-UV spectroscopy (50-210 nm), visible imaging (340-1080 nm), visible/near-infrared spectroscopy (0.49-5.56 & mu;m), and sub-millimetre sounding (near 530-625 GHz and 1067-1275 GHz). This is coupled to radio, stellar, and solar occultation opportunities to explore the atmosphere at high vertical resolution; and radio and plasma wave measurements of electric discharges in the Jovian atmosphere and auroras. Cross-disciplinary scientific investigations enable JUICE to explore coupling processes in giant planet atmospheres, to show how the atmosphere is connected to (i) the deep circulation and composition of the hydrogen-dominated interior; and (ii) to the currents and charged particle environments of the external magnetosphere. JUICE will provide a comprehensive characterisation of the atmosphere and auroras of this archetypal giant planet.
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- Koubarakis, M., et al.
(author)
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From copernicus big data to extreme earth analytics
- 2019
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In: Advances in Database Technology - EDBT. - : OpenProceedings. - 9783893180813 ; , s. 690-693
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Conference paper (peer-reviewed)abstract
- Copernicus is the European programme for monitoring the Earth. It consists of a set of systems that collect data from satellites and in-situ sensors, process this data and provide users with reliable and up-to-date information on a range of environmental and security issues. The data and information processed and disseminated puts Copernicus at the forefront of the big data paradigm, giving rise to all relevant challenges, the so-called 5 Vs: volume, velocity, variety, veracity and value. In this short paper, we discuss the challenges of extracting information and knowledge from huge archives of Copernicus data. We propose to achieve this by scale-out distributed deep learning techniques that run on very big clusters offering virtual machines and GPUs. We also discuss the challenges of achieving scalability in the management of the extreme volumes of information and knowledge extracted from Copernicus data. The envisioned scientific and technical work will be carried out in the context of the H2020 project ExtremeEarth which starts in January 2019.
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- Bruzzone, Silvia, Senior Lecturer, et al.
(author)
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Constructing collaborative communities of researchers in the environmental domain. A case study of interdisciplinary research between legal scholars and policy analysts
- 2016
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In: Environmental Science and Policy. - : Elsevier BV. - 1462-9011 .- 1873-6416. ; 64, s. 1-8
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Journal article (peer-reviewed)abstract
- The article offers an analysis of the interactions between legal and policy science researchers within a European project on flood risk management using a “Policy Arrangement Approach” (PAA). While interdisciplinary research is increasingly becoming a ‘must’ in environmental governance, under what conditions is cooperation possible and desirable? Our analysis shows that the PAA is not mobilized as an interdisciplinary method, but offers a framework for researchers from different disciplines to learn to work together on a subject such as flooding, requiring interdisciplinary insights. The paper shows the steps that are progressively put in place to reach a common language and reformulate issues by benefitting from each other’s view and approaches. The article concludes by drawing attention to new means of knowledge production relating to so-called “messy” or “wicked” problems, such as environmental issues. Within this framework, interdisciplinary work is not considered to be a pre-condition for the study, but rather the result of the research process itself. The analysis draws attention to the actual (working) conditions established to create an interdisciplinary community of flooding practices by challenging disciplinary borders.
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| 10. |
- Bulanova, Daria, et al.
(author)
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Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
- 2017
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In: Viruses. - : MDPI AG. - 1999-4915. ; 9:10
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Journal article (peer-reviewed)abstract
- Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases.
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| 11. |
- Hegger, D., et al.
(author)
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Shaping flood risk governance through science-policy interfaces : Insights from England, France and the Netherlands
- 2020
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In: Environmental Science and Policy. - : Elsevier Ltd. - 1462-9011 .- 1873-6416. ; 106, s. 157-165
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Journal article (peer-reviewed)abstract
- In the face of increasing threats from flooding, there are growing calls to strengthen and improve arrangements of flood risk governance (FRG). This endeavour requires an appreciation of the multitude of factors stabilising and driving governance dynamics. So-called catalyst flood events, policy champions and advocacy coalitions have tended to dominate this study to date, whilst the potential role played by Science Policy Interfaces (SPIs) has been somewhat neglected and often approached in a reductionist and fragmented way. This paper addresses this gap by drawing from in-depth policy analysis and stakeholder interviews conducted within England, France and the Netherlands under the auspices of the EU-FP7 STAR-FLOOD project. The analysis reveals four prominent ways in which SPIs shape FRG, by i) facilitating the diversification of Flood Risk Management (FRM) strategies; ii) increasing their connectivity, iii) facilitating a decentralisation of FRM and iv) fostering inter-country learning. It identifies different roles of specific interfaces (structures) and interfacing mechanisms (processes) in shaping governance dynamics. This way, the analysis reveals various ‘entry points’ through which SPIs can steer FRG, either along existing pathways, or towards new and potentially transformative change. The study shows that SPIs are a hitherto underexposed factor explaining dynamics in flood risk governance which merits additional systematic empirical study.
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| 14. |
- Stephan, K., et al.
(author)
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Regions of interest on Ganymede's and Callisto's surfaces as potential targets for ESA's JUICE mission
- 2021
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In: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 208
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Journal article (peer-reviewed)abstract
- The JUpiter Icy moons Explorer (JUICE) will investigate Ganymede's and Callisto's surfaces and subsurfaces from orbit to explore the geologic processes that have shaped and altered their surfaces by impact, tectonics, possible cryovolcanism, space weathering due to micrometeorites, radiation and charged particles as well as explore the structure and properties of the icy crust and liquid shell (Grasset et al., 2013). The best possible synergy of the JUICE instruments is required to answer the major science objective of this mission and to fully exploit the po-tential of the JUICE mission. Therefore, the JUICE team is aiming to define high priority targets on both Gany-mede's and Callisto's surfaces to support the coordination of the planning activities by the individual instrument teams. Based on the science objectives of the JUICE mission and the most recent knowledge of Ganymede's and Callisto's geologic evolution we propose a collection of Regions of Interest (RoIs), which characterize surface features and terrain types representing important traces of geologic processes, from past and/or present cryovolcanic and tectonic activity to space weathering processes, which are crucial to understand the geologic evolution of Ganymede and Callisto. The proposed evaluation of RoIs is based on their scientific importance as well as on the opportunities and conditions to observe them during the currently discussed mission profile.
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