| 1. |
- Krajcarz, M., et al.
(författare)
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The history of the domestic cat in Central Europe
- 2022
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Ingår i: Antiquity. - : Antiquity Publications. - 0003-598X .- 1745-1744. ; 96:390, s. 1628-1633
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Tidskriftsartikel (refereegranskat)abstract
- A recent study from Central Europe has changed our perception of the cat's domestication history. The authors discuss how this has led to the development of an interdisciplinary project combining palaeogenetics, zooarchaeologv and radiocarbon dating, with the aim of providing insight into the domestic cat's expansion beyond the Mediterranean.
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| 2. |
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| 3. |
- Fiddaman, Steven R., et al.
(författare)
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Ancient chicken remains reveal the origins of virulence in Marek's disease virus
- 2023
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Ingår i: Science (New York, N.Y.). - 1095-9203. ; 382:6676, s. 1276-1281
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Tidskriftsartikel (refereegranskat)abstract
- The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek's disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.
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| 4. |
- Frantz, Laurent A. F., et al.
(författare)
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Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe
- 2019
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 116:35, s. 17231-17238
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Tidskriftsartikel (refereegranskat)abstract
- Archaeological evidence indicates that pig domestication had begun by similar to 10,500 y before the present ( BP) in the Near East, and mitochondrial DNA ( mtDNA) suggests that pigs arrived in Europe alongside farmers similar to 8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their characteristic mtDNA signature disappeared and was replaced by haplotypes associated with European wild boars. This turnover could be accounted for by substantial gene flow from local European wild boars, although it is also possible that European wild boars were domesticated independently without any genetic contribution from the Near East. To test these hypotheses, we obtained mtDNA sequences from 2,099 modern and ancient pig samples and 63 nuclear ancient genomes from Near Eastern and European pigs. Our analyses revealed that European domestic pigs dating from 7,100 to 6,000 y BP possessed both Near Eastern and European nuclear ancestry, while later pigs possessed no more than 4% Near Eastern ancestry, indicating that gene flow from European wild boars resulted in a near-complete disappearance of Near East ancestry. In addition, we demonstrate that a variant at a locus encoding black coat color likely originated in the Near East and persisted in European pigs. Altogether, our results indicate that while pigs were not independently domesticated in Europe, the vast majority of human-mediated selection over the past 5,000 y focused on the genomic fraction derived from the European wild boars, and not on the fraction that was selected by early Neolithic farmers over the first 2,500 y of the domestication process.
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| 5. |
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| 6. |
- Horejs, B, et al.
(författare)
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New Multi-disciplinary Data from the Neolithic in Serbia. The 2019 and 2021 Excavations at Svinjarička Čuka
- 2022
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Ingår i: Archaeologia Austriaca. - : Osterreichische Akademie der Wissenschaften, Verlag. - 0003-8008 .- 1816-2959. ; 106, s. 255-317
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Tidskriftsartikel (refereegranskat)abstract
- The excavations at Svinjarička Čuka in the South Morava Valley in Serbia are presented with new primary data from the field and related material and scientific analyses. Newly recovered architectural remains from the classical Starčevo period revealed a variety of domestic features, so far belonging to an earlier and later occupation phase at the river terrace dating between 5700/5600 and 5500 BC. Details of the stratigraphy and certain materials are presented for selected domestic contexts, including one potential ‘Starčevo house’. Archaeological and scientific analyses are discussed and contextualised within the Neolithisation process in the chapters on new radiocarbon data and their Bayesian modelling, pottery studies, chipped stones and their raw material analyses, grinding kits, animal remains, archaeobotanical results and charcoal analysis. The later occupation at the site is presented with new results for the Middle and Late Bronze Age and the Early Iron Age, including domestic contexts, radiocarbon data and materials.
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| 7. |
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| 8. |
- Nordenfur, Tim, et al.
(författare)
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Method comparison for cardiac image registration of coronary computed tomography angiography and 3-D echocardiography
- 2018
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Ingår i: Journal of Medical Imaging. - : SPIE - International Society for Optical Engineering. - 2329-4302 .- 2329-4310. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Treatment decision for coronary artery disease (CAD) is based on both morphological and functional information. Image fusion of coronary computed tomography angiography (CCTA) and three-dimensional echocardiography (3DE) could combine morphology and function into a single image to facilitate diagnosis. Three semiautomatic feature-based methods for CCTA/3DE registration were implemented and applied on CAD patients. Methods were verified and compared using landmarks manually identified by a cardiologist. All methods were found feasible for CCTA/3DE fusion.
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| 9. |
- Sandoval-Castellanos, Edson, et al.
(författare)
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Ancient mitogenomes from Pre-Pottery Neolithic Central Anatolia and the effects of a Late Neolithic bottleneck in sheep (Ovis aries)
- 2024
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Ingår i: SCIENCE ADVANCES. - 2375-2548. ; 10:15
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Tidskriftsartikel (refereegranskat)abstract
- Occupied between similar to 10,300 and 9300 years ago, the Pre-Pottery Neolithic site of Asikli Hoyuk in Central Anatolia went through early phases of sheep domestication. Analysis of 629 mitochondrial genomes from this and numerous sites in Anatolia, southwest Asia, Europe, and Africa produced a phylogenetic tree with excessive coalescences (nodes) around the Neolithic, a potential signature of a domestication bottleneck. This is consistent with archeological evidence of sheep management at Asikli Hoyuk which transitioned from residential stabling to open pasturing over a millennium of site occupation. However, unexpectedly, we detected high genetic diversity throughout Asikli Hoyuk's occupation rather than a bottleneck. Instead, we detected a tenfold demographic bottleneck later in the Neolithic, which caused the fixation of mitochondrial haplogroup B in southwestern Anatolia. The mitochondrial genetic makeup that emerged was carried from the core region of early Neolithic sheep management into Europe and dominates the matrilineal diversity of both its ancient and the billion-strong modern sheep populations.
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