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- Ask, Maria, et al.
(författare)
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The Innovative Exploration Drilling and Data Acquisition Research School
- 2021
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Ingår i: NSG2021 27th European Meeting of Environmental and Engineering Geophysics. - : European Association of Geoscientists and Engineers.
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Konferensbidrag (refereegranskat)abstract
- The Innovative Exploration Drilling and Data Acquisition Research School (I-EDDA-RS) is aimed at educating emerging scientists and engineers in on-site drilling and geoscientific investigation technology for mining. I-EDDA-RS consists if a consortium of scientists and specialists from six universities and research institutes in Germany and Sweden. A central component of the research school is that the courses have hands-on components at drill sites, boreholes and repositories. In addition, a course on entrepreneurial skills required in the exploration industry is also included in I-EDDA-RS. The arrival of the Covid-19 pandemic resulted in altered plans. Instead of offering ten courses with strong field work, practical, and entrepreneurial components during 2020, four courses via distant learning were offered. While this was disappointing in many aspects, two of the courses attracted a larger group of students from a wider part of the world than original envisioned. Outreach via on-line and open webinars is also a route to explore, as a complement to meetings and conferences in real life. The I-EDDA-RS courses in 2021 welcomes students at MSc & PhD level, as well as experienced professionals for lifelong learning (c.f. https://www.iedda.eu/rs). The form and type of teaching is to be determined.
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- Juhlin, Christopher, et al.
(författare)
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Innovative Exploration Drilling and Data Acquisition Test Center: First Geophysical Site Survey
- 2019
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Konferensbidrag (refereegranskat)abstract
- Innovative Exploration Drilling and Data Acquisition (I-EDDA) was a Network of Infrastructure in the European Institute of Innovation & Technology (EIT) Knowledge and Innovation Community (KIC) "Raw Materials", running from 2016 to 2018. Its purpose was to unite partners from academia and industry to jointly address challenges that are expected to increase the value of mineral exploration related operations. The I-EDDA test center (I-EDDA-TC) is an outcome of I-EDDA and will allow real-world test drilling to verify improved and new technologies and provide critical feedback to the engineers. Improved or newly developed technology needs to be tested under real-world conditions and in an operational setting. However, a dedicated and well-characterised test site for diamond core-drilling from the surface and with realistic conditions is missing. I-EDDA-TC will include excellent access to infrastructure, workshop facilities and proximity to expertise in drilling. The planned test site location in Örebro (south-central Sweden) is easily accessible and is situated in Paleoproterozoic bedrock (gneisses and metasediments), similar to the bedrock of many mining districts that are located in crystalline rock. The test site is planned to cover an area of approximately 4000 m2. Characterisation of the physical and chemical parameters in the subsurface performed within I-EDDA-TC will allow for an integrated interpretation of technical and geoscientific test results. Geophysical investigations will be combined with a suite of fully-cored exploration boreholes of varying depth (some down to at least 1 km), as well as downhole and laboratory investigations. A long-term utilization of the test facility will be the ultimate goal, including an invitation to the research community and to companies to partake. In July 2019 the first geophysical surveys over the site were preformed, consisting of ground magnetics, geo-electrics, a small high resolution 3D seismic survey and a deeper 2D survey using a large vibrator source. The acquired data will form the basis for future geophysical and geochemical surveys and, ultimately, for planning test boreholes for advancing drilling methods and downhole measurements. We report here on first results from these measurements.
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- Schneider, Edith, et al.
(författare)
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MicroRNA-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.
- 2018
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 103, s. 246-255
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Tidskriftsartikel (refereegranskat)abstract
- MicroRNA-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR 155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells in vivo. However, in the absence or after the removal of miR-155, leukemia onset and progression were unaffected. Although, miR-155 accelerated growth and homing as well as impaired differentiation, our data underscore the pathophysiological relevance of miR 155 as an accelerator rather than a driver of leukemogenesis. This further highlights the complexity of the oncogenic program of Meis1 to compensate for the loss of a potent oncogene such as miR-155. These findings are highly relevant to current and developing approaches for targeting miR-155 in acute myeloid leukemia.
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- Simon, H., et al.
(författare)
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Anisotropic Kirchhoff pre-stack depth migration at the COSC-1 borehole, central Sweden
- 2019
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Ingår i: Geophysical Journal International. - : OXFORD UNIV PRESS. - 0956-540X .- 1365-246X. ; 219:1, s. 66-79
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Tidskriftsartikel (refereegranskat)abstract
- A remarkably well preserved representation of a deeply eroded Palaeozoic orogen is found in the Scandinavian Caledonides, formed by the collision of the two palaeocontinents Baltica and Laurentia. Today, after 400 Ma of erosion along with uplift and extension during the opening of the North Atlantic Ocean, the geological structures in central western Sweden comprise far transported allochthonous units, the underlying Precambrian crystalline basement, and a shallow west-dipping decollement that separates the two and is associated with a thin layer of Cambrian black shales. These structures, in particular the Seve Nappes (upper part of the Middle Allochthons), the Lower Allochthons and the highly reflective basement are the target of the two approximately 2.5 km deep fully cored scientific boreholes in central Sweden that are part of the project COSC (Collisional Orogeny in the Scandinavian Caledonides). Thus, a continuous 5 km tectonostratigraphic profile through the Caledonian nappes into Baltica's basement will be recovered. The first borehole, COSC-1, was successfully drilled in 2014 and revealed a thick section of the seismically highly reflective Lower Seve Nappe. The Seve Nappe Complex, mainly consisting of felsic gneisses and mafic amphibolites, appears to be highly anisotropic. To allow for extrapolation of findings from core analysis and downhole logging to the structures around the borehole, several surface and borehole seismic experiments were conducted. Here, we use three long offset surface seismic profiles that are centred on the borehole COSC-1 to image the structures in the vicinity of the borehole and below it. We applied Kirchhoff pre-stack depth migration, taking into account the seismic anisotropy in the Seve Nappe Complex. We calculated Green's functions using an anisotropic eikonal solver for a VTI (transversely isotropic with vertical axis of symmetry) velocity model, which was previously derived by the analysis of VSP (Vertical Seismic Profile) and surface seismic data. We show, that the anisotropic results are superior to the corresponding isotropic depth migration. The reflections appear significantly more continuous and better focused. The depth imaging of the long offset profiles provides a link between a high-resolution 3-D data set and the regional scale 2-D COSC Seismic Profile and complements these data sets, especially in the deeper parts below the borehole. However, many of the reflective structures can be observed in the different data sets. Most of the dominant reflections imaged originate below the bottom of the borehole and are situated within the Precambrian basement or at the transition zones between Middle and Lower Allochthons and the basement. The origin of the deeper reflections remains enigmatic, possibly representing dolerite intrusions or deformation zones of Caledonian or pre-Caledonian age.
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