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- Clyne, N, et al.
(författare)
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The intracellular distribution of cobalt in exposed and unexposed rat myocardium
- 1990
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513 .- 1502-7686. ; 50:6, s. 605-609
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Tidskriftsartikel (refereegranskat)abstract
- The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.
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- Hagren, B., et al.
(författare)
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Maintenance hemodialysis : patients´ experiences of their life situation
- 2005
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Ingår i: Journal of Clinical Nursing. - 0962-1067 .- 1365-2702. ; 14:3, s. 294-300
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Aim. The aim of this study was to examine how patients suffering from CKD on maintenance haemodialysis experience their life situation. The focus was on how treatment encroaches on time and space and how patients experience care. The rationale was that this knowledge is necessary to provide professional support that takes into consideration a person's whole life situation. Background. The experiences of patients with chronic kidney disease (CKD) undergoing maintenance haemodialysis have been studied in many quantitative studies, which translate patients' subjective experiences into objectively quantifiable data. However, there are few qualitative studies examining the experiences of these patients' life situation and expressing their experiences within the context of a nursing and caregiver's perspective. Method. Data were collected by interviews with 41 patients between the ages of 29 and 86 years who participated in the study. A content analysis was used to identify common themes that describe the patients' experiences of their life situation. Results. Three main themes were identified, 'not finding space for living', 'feelings evoked in the care situation' and, 'attempting to manage restricted life'. The first theme 'not finding space for living' consisted of two sub-themes: 'struggling with time-consuming care' and 'feeling that life is restricted'. The second theme 'feelings evoked in the care situation' consisted of two sub-themes: 'sense of emotional distance' and 'feeling vulnerable'. Conclusions. The patients in this study indirectly expressed an existential struggle, indicating that encroachment of time and space were important existential dimensions of CKD. The findings indicated that caregivers were not always aware of this inducing a sense of emotional distance and a sense of vulnerability in the patients. Relevance to clinical practice. Caregivers in dialysis units have to consider haemodialysis patients' experience of a sense of emotional distance in their relationship to caregivers. Nurses and doctors need to create routines within nursing practice to overcome this.
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- Heiwe, S, et al.
(författare)
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Twelve weeks of exercise training increases muscle function and walking capacity in elderly predialysis patients and healthy subjects
- 2001
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Ingår i: Nephron. - : S. Karger AG. - 1660-8151 .- 2235-3186. ; 88:1, s. 48-56
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Tidskriftsartikel (refereegranskat)abstract
- Muscle function declines with age and progressive uraemia. We examined whether elderly predialysis patients could improve thigh muscle function, walking capacity, and functional mobility to the same extent as elderly healthy subjects when participating in 12 weeks of individual muscle endurance exercises for the thigh as well as in a low-intensive group programme. The uraemic exercise and comparison groups comprised 16 patients (age 76 ± 7 years, glomerular filtration rate 18 ± 5 ml/min) and 9 patients (age 72 ± 6 years, glomerular filtration rate 16 ± 5 ml/min), respectively. The healthy exercise and comparison groups comprised 18 subjects (age 75 ± 7 years) and 5 subjects (age 79 ± 4 years), respectively. Muscular strength, dynamic endurance, walking capacity, and functional mobility increased significantly in both the uraemic and the healthy exercise groups after 12 weeks of regular muscle endurance exercise training, whereas there was no significant change in static muscle endurance and quality of life in either group. None of the values changed for the uraemic comparison group nor the healthy comparison group during the observation period. Elderly predialysis patients had lower muscle function and mobility as compared with elderly healthy subjects, but were able to improve both after 12 weeks of exercise training to the same extent as elderly healthy subjects.
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- Klang, B, et al.
(författare)
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Quality of life in predialytic uremic patients
- 1996
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Ingår i: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. - 0962-9343. ; 5:1, s. 109-116
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Tidskriftsartikel (refereegranskat)
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