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| 2. |
- Perego, A., et al.
(författare)
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Neutrino-driven winds from neutron star merger remnants
- 2014
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 443:4, s. 3134-3156
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Tidskriftsartikel (refereegranskat)abstract
- We present a detailed, three-dimensional hydrodynamic study of the neutrino-driven winds emerging from the remnant of a neutron star merger. Our simulations are performed with the Newtonian, Eulerian code FISH, augmented by a detailed, spectral neutrino leakage scheme that accounts for neutrino absorption. Consistent with earlier two-dimensional studies, a strong baryonic wind is blown out along the original binary rotation axis within approximate to 100 ms. From this model, we compute a lower limit on the expelled mass of 3.5 x 10(-3) M-circle dot, relevant for heavy element nucleosynthesis. Because of stronger neutrino irradiation, the polar regions show substantially larger electron fractions than those at lower latitudes. The polar ejecta produce interesting r-process contributions from A approximate to 80 to about 130, while the more neutron-rich, lower latitude parts produce elements up to the third r-process peak near A approximate to 195. We calculate the properties of electromagnetic transients powered by the radioactivity in the wind, in addition to the 'macronova' transient stemming from the dynamic ejecta. The polar regions produce ultraviolet/optical transients reaching luminosities up to 10(41) erg s(-1), which peak around 1 d in optical and 0.3 d in bolometric luminosity. The lower latitude regions, due to their contamination with high-opacity heavy elements, produce dimmer and more red signals, peaking after similar to 2 d in optical and infrared.
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| 3. |
- Celis, Julio E., et al.
(författare)
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15-Prostaglandin Dehydrogenase Expression Alone or in Combination with ACSM1 Defines a Subgroup of the Apocrine Molecular Subtype of Breast Carcinoma
- 2008
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Ingår i: Molecular & Cellular Proteomics. - 1535-9484. ; 7:10, s. 1795-1809
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Tidskriftsartikel (refereegranskat)abstract
- Established histopathological criteria divide invasive breast carcinomas into defined groups. Ductal of no specific type and lobular are the two major subtypes accounting for around 75 and 15% of all cases, respectively. The remaining 10% include rarer types such as tubular, cribriform, mucinous, papillary, medullary, metaplastic, and apocrine breast carcinomas. Molecular profiling technologies, on the other hand, subdivide breast tumors into five subtypes, basal-like, luminal A, luminal B, normal breast tissue-like, and ERBB2-positive, that have different prognostic characteristics. An additional subclass termed "molecular apocrine" has recently been described, but these lesions did not exhibit all the histopathological features of classical invasive apocrine carcinomas (IACs). IACs make up 0.5-3% of the invasive ductal carcinomas, and despite the fact that they are morphologically distinct from other breast lesions, there are presently no standard molecular criteria available for their diagnosis and as a result no precise information as to their prognosis. Toward this goal our laboratories have embarked in a systematic proteomics endeavor aimed at identifying biomarkers that may characterize and subtype these lesions as well as targets that may lead to the development of novel targeted therapies and chemoprevention strategies. By comparing the protein expression profiles of apocrine macrocysts and non-malignant breast epithelial tissue we have previously reported the identification of a few proteins that are specifically expressed by benign apocrine lesions as well as by the few IACs that were available to us at the time. Here we reiterate our strategy to reveal apocrine cell markers and present novel data, based on the analysis of a considerably larger number of samples, establishing that IACs correspond to a distinct molecular subtype of breast carcinomas characterized by the expression of 15-prostaglandin dehydrogenase alone or in combination with a novel form of acyl-CoA synthetase medium-chain family member 1 (ACSM1). Moreover we show that 15-prostaglandin dehydrogenase is not expressed by other breast cancer types as determined by gel-based proteomics and immunohistochemistry analysis and that antibodies against this protein can identify IACs in an unbiased manner in a large breast cancer tissue microarray making them potentially useful as a diagnostic aid. Molecular & Cellular Proteomics 7: 1795-1809, 2008.
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| 4. |
- Gizzi, Davide, 1992-, et al.
(författare)
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A multidimensional implementation of the Advanced Spectral neutrino Leakage scheme
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 490:3, s. 4211-4229
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Tidskriftsartikel (refereegranskat)abstract
- We present a new, multidimensional implementation of the Advanced Spectral Leakage (ASL) scheme with the purpose of modelling neutrino–matter interactions in neutron star mergers. A major challenge is the neutrino absorption in the semitransparent regime, which is responsible for driving winds from the merger remnant. The composition of such winds is crucial in the understanding of the electromagnetic emission in the recently observed macronova following GW170817. Compared to the original version, we introduce an optical-depth-dependent flux factor to model the average angle of neutrino propagation, and a modulation that accounts for flux anisotropies in non-spherical geometries. We scrutinize our approach by first comparing the new scheme against the original one for a spherically symmetric core-collapse supernova snapshot, both in 1D and in 3D, and additionally against a two-moment (M1) scheme as implemented in 1D into the code GR1D. The luminosities and mean energies agree to a few per cents in most tests. Finally, for the case of a binary merger remnant snapshot we compare the new ASL scheme with the M1 scheme that is implemented in the Eulerian adaptive mesh refinement code FLASH. We find that the neutrino absorption distribution in the semitransparent regime is overall well reproduced. Both approaches agree to within 15 per cent for the average energies and to better than ∼ 35 per cent in the total luminosities.
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